KR20210004233A - Passive sampler and Preparation method thereof - Google Patents

Abstract

The present invention relates to a manual picker that changes color by reacting with a gas and a method for manufacturing the same. According to the present invention, the manual picker comprises a dye (benzidine compound) that changes color by reacting with a gas having oxidizing ability on a substrate, so that when exposed to a gas having an oxidizing ability such as chlorine gas, the color of the manual picker is developed or discolored. Accordingly, it is simple and economical, and there is an effect of confirming whether the substrate is exposed to a gas having oxidizing ability and the degree of exposure in a short time.

Description

Manual sampler and manufacturing method thereof {Passive sampler and Preparation method thereof}

The present invention relates to a manual extractor that changes color by reacting with a gas and a method of manufacturing the same.

Chlorine-based disinfectants, which are often used for sterilization and cleaning at home and at work, are mainly composed of hypochlorous acid, calcium hypochlorite, sodium hypochlorite, and chlorine and hypochlorite when used. It generates hypochlorous acid gas.

Exposure to chlorine gas can cause reactive airways dysfunction syndrome (RADS), an irritant-induced asthma, and can cause lung damage when exposed to high concentrations of chlorine gas.

As described above, as a conventional technique for confirming the exposure and concentration of chlorine and chlorine gas harmful to the human body, a signal line connected to the meter is transmitted through the diaphragm from the electrode portion formed on the sensor body. The residual chlorine concentration in the water is measured by chlorine gas, and the durability and replacement time can be determined through the color change of the measuring part.The residual chlorine measurement sensor is used to prevent deformation and protect the diaphragm and to check the contamination status. In addition, a non-diaphragm three-electrode residual chlorine sensor is proposed that does not use a diaphragm, and does not use a diaphragm, and is not affected by the measurement range according to the hydrogen ion concentration using a reverse-potential electrode and a reference electrode.

However, the chlorine measurement sensor measures the concentration of chlorine and chlorine using an electrode, and the configuration of a battery, etc. is inevitably required, and the configuration is also complicated and not economical, and it is difficult to use easily in daily life. there was.

That is, chlorine-based disinfectants are used in various consumer products for the purpose of sterilization and cleaning, but general consumers can easily and conveniently check the level of exposure to harmful gases due to the use of chlorine-based disinfectants, and there were no wearable sensors.

Therefore, by making a sensor that can easily estimate the exposure level of harmful gases generated when using chlorine-based disinfectants in a wearable form, general consumers can easily identify exposure to harmful gases during work, thereby preventing high concentrations and long-term exposure. Development of a chlorine gas sampler and sensor is required.

Korean Patent Registration No. 10-1507331 Korean Patent Registration No. 10-1575008

An object of the present invention is to see whether or not to expose and expose a gas by changing the color of the dye by reacting the dye and the gas when exposed to a gas having an oxidizing ability such as chlorine gas by doping a dye that is oxidized and colored when reacting with a gas having an oxidizing ability. It is to provide a manual extractor and a manufacturing method thereof that can check the degree.

The present invention, the substrate; And a benzidine compound,

The thickness of the manual extractor is 0.3 to 1.0 mm,

It provides a manual extractor, characterized in that the content of the benzidine compound is an average of 0.05 to 0.8 μg / cm ² .

In addition, the present invention comprises the steps of preparing a dye solution by mixing a benzidine compound with a solvent; And

Including the step of doping the substrate with a benzidine compound by introducing a substrate into the dye solution,

The concentration of the benzidine compound in the dye solution is an average of 0.05 to 0.8 g/L,

It provides a method of manufacturing a manual extractor, characterized in that the thickness of the substrate is 0.3 to 1.0 mm.

The manual extractor according to the present invention includes a dye (benzidine compound) that changes color by reacting with a gas having an oxidizing ability on the substrate, so that the color of the manual extractor develops or discolors when exposed to a gas having an oxidizing ability such as chlorine gas. It is economical and has the effect of being able to check whether or not the gas having oxidizing ability is exposed and the degree of exposure in a short time.

1 is a photograph of a manual extractor after an experiment for detecting chlorine gas using a manual extractor according to the present invention.
Figure 2 is a graph of the result of spectroscopic analysis of the extraction solvent before and after extraction of the gas exposed in the manual extractor according to the present invention: (a) is a graph of the extraction solvent 1 (acetonitrile) extracted by the manual extractor before gas exposure, (b) is a graph of extraction solvent 1 (acetonitrile) extracted from the manual extractor after exposure to gas, (a) is a graph of extraction solvent 2 (isopropyl alcohol) extracted from the manual extractor before exposure to gas, and (b) is gas This is a graph of extraction solvent 2 (isopropyl alcohol) extracted by a manual extractor after exposure.
3 is a flow chart showing a method of manufacturing a manual extractor according to the present invention.

In the present invention, various modifications may be made and various embodiments may be provided, and specific embodiments will be illustrated in the drawings and described in detail in the detailed description.

However, this is not intended to limit the present invention to a specific embodiment, it is to be understood to include all changes, equivalents, and substitutes included in the spirit and scope of the present invention.

The present invention is a part of a study to develop a manual extractor that can check the exposure and concentration of gas having oxidizing ability in a simple, economical, and fast manner. The substrate is doped with a dye that is oxidized and colored when reacting with a gas having oxidizing ability. , The present invention relates to a manual extractor capable of confirming the exposure and degree of exposure to gas (especially chlorine gas) having oxidizing ability through color development and discoloration of the manual extractor, and a method of manufacturing the same.

The present invention, the substrate; And a benzidine compound,

The thickness of the manual extractor is 0.3 to 1.0 mm,

It provides a manual extractor, characterized in that the content of the benzidine compound is an average of 0.05 to 0.8 μg / cm ² .

The substrate may be one or more selected from the group consisting of fiber, glass, plastic, and paper. Specifically, the substrate may be one or more selected from polydimethylsiloxane (PDMS), polyacrylate (PA), polydimethylsiloxane/divinylbenzene (PDMS/DVB), and polystyrene (PS) polymer. More specifically, the substrate may be polydimethylsiloxane, polyacrylate, polydimethylsiloxane/divinylbenzene, or polystyrene polymer.

In addition, the benzidine compound is o-dianisidine, 3,3'-dimethoxybenzidine, and 3,3'-dichlorobenzidine. It may be one or more selected from the group consisting of. Specifically, the benzidine compound is o-dianisidine, 3,3'-dimethoxybenzidine, or 3,3'-dichlorobenzidine. I can. Since the benzidine compound as described above reacts with a gas having oxidizing ability (especially chlorine) and is oxidized, it can be seen that it is exposed to the gas by developing a green color color, and the exposure amount of the gas can be measured by the concentration of the benzidine compound.

As an example, the manual extractor according to the present invention may have an average content of a benzidine compound of 0.05 to 0.8 μg/cm ² . Specifically, the content of the benzidine compound is on average 0.05 to 0.7 μg/cm ² , 0.05 to 0.6 μg/cm ² , 0.05 to 0.5 μg/cm ² , 0.1 to 0.8 μg/cm ² , 0.1 to 0.7 μg/cm ² , 0.1 To 0.6 μg/cm ² , 0.1 to 0.5 μg/cm ² , 0.1 to 0.4 μg/cm ² , 0.2 to 0.8 μg/cm ² , 0.2 to 0.7 μg/cm ² , 0.2 to 0.6 μg/cm ² , 0.2 to 0.5 μg/cm ² , 0.2 to 0.4 μg/cm ² , 0.25 to 0.7 μg/cm ² , 0.25 to 0.4 μg/cm ² , 0.25 to 0.5 μg/cm ^2, or 0.25 to 0.35 μg/cm ² . When the benzidine compound is included in the above concentration, vivid color may be exhibited when reacting with a gas having oxidizing ability without causing crystallization.

In addition, the thickness of the manual extractor according to the present invention may be 0.3 to 1.0 mm. Specifically, the thickness of the manual extractor of the present invention is 0.3 to 0.9 mm, 0.3 to 0.8 mm, 0.3 to 0.7 mm, 0.3 to 0.6 mm, 0.4 to 1.0 mm, 0.4 to 0.9 mm, 0.4 to 0.8 mm, 0.4 to 0.7 mm Or 0.4 to 0.6 mm. By having the thickness as described above, the manual extractor may have a characteristic that the color changes according to the accumulated amount of gas when reacted with a gas (especially chlorine) having an oxidizing ability.

As another example, the manual extractor according to the present invention may be discolored by reacting with a gas having oxidizing ability. Specifically, the passive extractor may change color to green at the initial exposure to a gas having an oxidizing ability, and then to a red color as the amount of the exposed gas increases. In addition, the manual extractor can measure the amount of gas exposure from the manual extractor after being exposed to a gas having oxidizing ability.

At this time, the gas having oxidizing ability may be chlorine, ozone, oxygen, chlorine dioxide, or hydrogen peroxide. Specifically, the gas having an oxidizing ability may be chlorine or ozone. More specifically, the gas having oxidizing ability may be chlorine gas.

The manual extractor according to the present invention is not particularly limited as long as it is a wearable type, but may be specifically in the form of a sticker, a clip, a wristband, or a name tag.

In addition, the present invention comprises the steps of preparing a dye solution by mixing a benzidine compound with a solvent; And

Including the step of doping the substrate with a benzidine compound by introducing a substrate into the dye solution,

The concentration of the benzidine compound in the dye solution is an average of 0.05 to 0.8 g/L,

It provides a method of manufacturing a manual extractor, characterized in that the thickness of the substrate is 0.3 to 1.0 mm.

A specific method of manufacturing a manual extractor according to the present invention is shown in FIG. 3. Referring to Figure 3, the manufacturing method of the manual extractor according to the present invention is to mix a cleanly washed substrate (PDMS sheet, 20) with a solvent and immerse the benzidine compound at room temperature in a dye solution 10 to doping the substrate with the benzidine compound. Step (a); (B) taking out the substrate 21 doped with the benzidine compound (11) and drying it in a hood at room temperature for about 1 to 2 hours to evaporate the solvent; And (c) immersing the dried substrate in methanol for 1 to 2 minutes to wash the benzidine compound remaining on the surface.

As an example, in the step of preparing a dye solution, a dye solution may be prepared by mixing a benzidine compound that is oxidized and colored upon reaction with chlorine with a solvent.

The solvent is toluene, acetonitrile, acetone, xylene, dimethyl sulfoxide (DMSO), dimethylformamide (DMF), tetrahydrofuran (THF), benzene, ether, methanol, hexane, cyclohexane, pyridine, acetic acid, carbon tetrachloride , Chloroform, dichloromethane, ethyl acetate, and may be one or more selected from the group consisting of ethylbenzene. Specifically, the solvent may be toluene, benzene or hexane.

In addition, the benzidine compound is o-dianisidine, 3,3'-dimethoxybenzidine, and 3,3'-dichlorobenzidine. It may be one or more selected from the group consisting of. Specifically, the benzidine compound is o-dianisidine, 3,3'-dimethoxybenzidine, or 3,3'-dichlorobenzidine. I can. Since the benzidine compound as described above reacts with a gas having oxidizing ability (especially chlorine) and is oxidized, it can be seen that it is exposed to the gas by developing a green color color, and the exposure amount of the gas can be measured by the concentration of the benzidine compound.

As an example, the dye solution may contain a benzidine compound at an average concentration of 0.05 to 0.8 g/L. More specifically, the dye solution contains a benzidine compound on average 0.05 to 0.7 g/L, 0.05 to 0.6 g/L, 0.05 to 0.5 g/L, 0.2 to 0.8 g/L, 0.2 to 0.7 g/L, 0.2 to 0.6g/L, 0.2 to 0.5g/L, 0.35 to 0.8g/L, 0.35 to 0.7g/L, 0.35 to 0.6g/L, 0.35 to 0.5g/L, or 0.4 to 0.55g/L can do. When the benzidine compound is mixed at the concentration as described above, vivid color may be exhibited when reacting with a gas having an oxidizing ability without causing crystallization.

As an example, the step of doping the substrate with the benzidine compound by adding the substrate to the dye solution may be performed by immersing or immersing the substrate in the dye solution. Specifically, the step of doping the benzidine compound on the substrate may be performed for 12 to 36 hours at a temperature of 15 to 40°C. More specifically, the step of doping the benzidine compound on the substrate is 12 to 30 hours, 15 to 30 hours, 20 to 36 hours at a temperature of 15 to 40 ℃, 15 to 35 ℃, 20 to 30 ℃ or 20 to 25 ℃, It can be carried out for 20 to 30 hours or 20 to 25 hours. When doping is performed under the above-described conditions, a benzidine compound, which is a dye, sufficiently penetrates into the substrate, thereby improving loading characteristics, thereby exhibiting a vivid color change.

The substrate may be one or more selected from the group consisting of fiber, glass, plastic, and paper. Specifically, the substrate may be at least one selected from polydimethylsiloxane (PDMS), polyacrylate (PA), polydimethylsiloxane/divinylbenzene (PDMS/DVB), and polystyrene (PS) polymer. More specifically, the substrate may be polydimethylsiloxane, polyacrylate, polydimethylsiloxane/divinylbenzene, or polystyrene polymer.

The thickness of the substrate may be 0.3 to 1.0 mm. Specifically, the thickness of the substrate is 0.3 to 0.9 mm, 0.3 to 0.8 mm, 0.3 to 0.7 mm, 0.3 to 0.6 mm, 0.4 to 1.0 mm, 0.4 to 0.9 mm, 0.4 to 0.8 mm, 0.4 to 0.7 mm or 0.4 to It can be 0.6 mm. By having the above thickness, when the benzidine compound is effectively absorbed into the substrate and reacted with a gas having an oxidizing ability (especially, chlorine), the color may change according to the accumulated amount of the gas.

As another example, the method of manufacturing a manual extractor according to the present invention may further include a step of drying after the step of doping the substrate with a benzidine compound.

The drying step is a step of removing and drying the substrate doped with the benzidine compound from the dye solution. Specifically, the drying may be performed for 6 to 36 hours at a temperature of 15 to 50°C. More specifically, the drying step is 0.5 to 3 hours, 0.5 to 2 hours at a temperature of 15 to 50 ℃, 20 to 45 ℃, 30 to 50 ℃, 20 to 30 ℃, 25 to 40 ℃ or 25 to 35 ℃ , Can be carried out for 1 to 3 hours or 1 to 2 hours. Through the drying step as described above, the solvent (toluene) can be effectively removed.

In addition, after the drying step, a process of removing impurities remaining on the substrate surface with a solvent may be performed. The solvent may be one or more selected from the group consisting of methanol, ethanol and acetone. Specifically, the solvent may be methanol or ethanol.

In addition, the present invention provides a method for measuring the amount of gas leakage using the manual extractor described above.

The gas leakage measurement method according to the present invention quantifies the amount of the benzidine compound that has reacted with the gas having oxidizing ability by extracting the doped benzidine compound in the manual extractor with an extraction solvent and presents the concentration of the gas having oxidizing ability to measure the gas leakage. can.

As an example, the step of supporting a manual extractor exposed to a gas having an oxidizing ability for a predetermined time or longer in an extraction solvent; And measuring the amount of gas leakage by measuring the amount of gas having oxidizing ability extracted with the extraction solvent.

Specifically, the step of supporting the manual extractor in the extraction solvent may be performed by supporting the manual extractor exposed to the gas in the extraction solvent for a predetermined time or longer at room temperature (20 to 25°C) for 12 to 72 hours. More specifically, the manual extractor exposed to the gas in the extraction solvent for a certain period of time or more may be carried at room temperature for 12 to 48 hours or 12 to 72 hours. For example, the extraction solvent may be isopropyl alcohol.

In addition, the step of measuring the amount of gas leakage may be performed at room temperature using an ultraviolet/visible light spectrophotometer (UV/VIS Spectrophotometer). Specifically, in the step of measuring the amount of gas leakage, the amount of gas leakage may be determined by quantitatively analyzing the extraction solvent including the benzidine compound extracted from the manual extractor through an ultraviolet/visible light spectrometer. More specifically, the amount of gas leakage can be calculated by analyzing the amount of the o-dianisidine compound extracted in isopropyl alcohol through an ultraviolet/visible light spectrometer.

Hereinafter, the present invention will be described in more detail through examples according to the present invention, but the scope of the present invention is not limited by the examples presented below.

Example 1

O-dianisidine was prepared as a dye, polydimethylsiloxane (PDMS) was prepared as a substrate, and toluene was prepared as a solvent. 7.65 mg of o-dianicidin was dissolved in 15 mL of toluene (o-dianicidin concentration: 0.5 g/L), and 0.55 mm thick PDMS (1.5 cm × 1.5 cm) was added to this solution at room temperature for 24 hours. Immerse. PDMS was removed from the dye solution and dried at a temperature of 20 to 30° C. for 1 to 2 hours to completely evaporate toluene to prepare a manual extractor.

Comparative Example 1

After dissolving 1.8 mg of o-dianicidin in 15 mL of toluene (o-dianicidin concentration: 0.12 g/L), 0.21 mm thick PDMS (1.5 cm × 1.5 cm) was added to this solution at room temperature for 24 hours. Immerse. PDMS was removed from the dye solution and dried at a temperature of 20 to 30° C. for 1 to 2 hours to completely evaporate toluene to prepare a manual extractor.

Comparative Example 2

After dissolving 3mg of o-dianicidin in 15mL of toluene (o-dianicidin concentration: 0.20g/L), 0.21mm thick PDMS (1.5cm × 1.5cm) was immersed in this solution at room temperature for 24 hours. do. PDMS was removed from the dye solution and dried at a temperature of 20 to 30° C. for 1 to 2 hours to completely evaporate toluene to prepare a manual extractor.

Comparative Example 3

After dissolving 4.5 mg of o-dianicidin in 15 mL of toluene (o-dianicidin concentration: 0.30 g/L), 0.21 mm thick PDMS (1.5 cm × 1.5 cm) was immersed in this solution for 24 hours. . PDMS was removed from the dye solution and dried at a temperature of 20 to 30° C. for 1 to 2 hours to completely evaporate toluene to prepare a manual extractor.

Comparative Example 4

7.65 mg of o-dianicidin was dissolved in 15 mL of toluene (o-dianicidin concentration: 0.50 g/L), and 0.21 mm thick PDMS (1.5 cm × 1.5 cm) was immersed in this solution for 24 hours. . PDMS was removed from the dye solution and dried at a temperature of 20 to 30° C. for 1 to 2 hours to completely evaporate toluene to prepare a manual extractor.

Experimental Example 1: Comparison of crystallization generation and color sensitivity according to PDMS thickness

(1) The degree of crystallization and color sensitivity according to the thickness of the substrate

In order to check the gas sensitivity according to the thickness of the manual extractor according to the present invention, a manual extractor in the headspace of a 20mL vial containing a degree of crystallization and a 5 mL chlorine-based disinfectant for the manual extractors of Example 1 and Comparative Examples 1 to 4 Was placed and exposed for 150 minutes to observe the color sensitivity, and the results are shown in Table 1 below.

PDMS thickness
(mm) 0.21 0.55 Toluene mine
concentration of o-dianisidine (g/L) 0.12 0.20 0.30 0.50 0.50 Photo of crystallinity of manual extractor

Photo of color sensitivity of the manual extractor

Looking at Table 1, when a 0.21 mm thick substrate (PDMS) is used as in Comparative Examples 1 to 4, it can be seen that crystallization occurs in all sensors containing 0.12 to 0.5 g/L of dye, especially Comparative Example 3 And 4, it can be seen that crystallization occurs a lot. In addition, when the manual extractor is exposed to the chlorine-based disinfectant, it can be seen that a 0.21mm thick manual extractor (Comparative Example) and a 0.55mm thick manual extractor (Example) have a faster color change. However, the manual extractor of Example 1 did not have a fast color change rate, but the color change clearly increased as time passed by exposure to chlorine gas in the headspace of the vial, whereas the manual sampler of Comparative Examples 1 to 4 It can be seen that the harvester does not. Specifically, the manual extractor of Example 1 is characterized in that it changes from a green series to a red color as the exposure time increases at the beginning according to the cumulative gas exposure, but in Comparative Examples 1 and 2, the crystallization reaction is relatively small, and is immediately red. It can be seen that the color change according to the cumulative exposure amount cannot be observed by looking at the change in series.

In addition, in the case of Comparative Examples 3 and 4, since crystallization occurred, o-dianisidine was not uniformly doped in the sub-phase, but the dye was doped on the PDMS sheet in the crystal phase. It seems difficult for the reaction to occur consistently.

Through this, when 0.21mm thick PDMS is used as a substrate, the initial color change appears faster than when 0.55mm thick PDMS is used, but the degree of color change is not large, and crystallization proceeds a lot and is uniformly doped. Compared to, it can be confirmed that the dye is not suitable because there is a possibility that a certain reaction does not occur with a gas having an oxidizing ability.

Therefore, in the manual extractor according to the present invention, the benzidine compound is uniformly doped in the substrate, resulting in a distinct color change, allowing not only to recognize the gas having oxidizing ability, but also to quantify the amount of reacted o-dianisidine. You can estimate the amount of oxidizing gas.

(2) Crystallization degree and color sensitivity depending on dye concentration

In order to check the characteristic change according to the dye concentration of the manual extractor according to the present invention, dyes of different concentrations (0.093g/L, 0.50g/L, 0.87g/L, 2g/L) in 0.55mm thick PDMS (o -Danisidin) 0.55mm thick PDMS (1.5cm×1.5cm) was immersed at room temperature for 24 hours and dried to prepare a manual extractor, and the manufactured manual extractor was placed on the top of a 20mL vial containing a chlorine-based disinfectant ( headspace) and exposed to gas generated by a chlorine-based disinfectant, and the crystallinity and color sensitivity thereof were measured, and the results are shown in Table 2 below.

Toluene mine
concentration of o-dianisidine (g/L) 0.093g/L 0.50 g/L 0.87g/L 2g/L Crystallinity picture

(결정화 없음)

(No crystallization)

(No crystallization)

(Generate crystallization)

(Generate crystallization) Color sensitivity photo

Looking at Table 2, it can be seen that in the case of a manual extractor having a concentration of o-dianisidine of 0.87 g/L, some crystallization is generated, and of a manual extractor containing a higher concentration of 2 g/L o-dianisidine. In this case, it can be confirmed that crystallization has progressed a lot.

When a comparison of 0.093 g/L and 0.50 g/L in which crystallization did not occur, a manual extractor containing 0.50 g/L can visually confirm that the color change occurs more when exposed to a chlorine-based disinfectant.

Through this, it can be seen that the concentration of an appropriate dye (o-dianisidine) for doping the substrate (PDMS) is about 0.05 to 0.8 g/L.

Experimental Example 2: Product applicability experiment

In order to confirm the possibility of commercialization of the manual extractor according to the present invention, the possibility of detecting exposure gas when the general consumer wears the manual extractor during work was measured for the manual extractor according to Example 1, and the results are shown in FIG. Specific experimental conditions are as follows.

<Detectability test conditions>

-Product used: Spray type chlorine-based disinfectant

-Type of work: Toilet cleaning (spray a spray-type disinfectant on floor tiles, toilets, and sinks about 1-2 seconds 20 times, then wash with cold water)

-Total working time: 15 minutes (after 15 minutes, the eyes feel a little sore)

-Working area: 5.57 m ²

-The ventilation port was not operated, but the toilet door was opened and the manual extractor of Example 1 was attached to the upper chest and worked.

As a result of the detection possibility, it was confirmed with the naked eye that the color of the manual extractor, which was transparent 1 to 2 minutes after spraying of the spray-type chlorine-based disinfectant, changed from the edge to green. During work, the intensity of the color change of the manual extractor gradually increased, and after 15 minutes, the color change of the manual extractor appeared as shown in FIG. 1.

Through this, it was confirmed that the general consumer can recognize the chlorine gas generated from the chlorine-based disinfectant with a clear color change using the manual extractor according to the present invention.

Experimental Example 3: Exposed gas extraction solvent compatibility

Acetonitrile (ACN) (0.1% formic acid) and isopropyl as extraction solvents in order to find an appropriate extraction solvent for confirming the exposure amount of gas generated by the use of a chlorine-based disinfectant using the manual extractor according to the present invention. alcohol, ISP) to extract the manual extractor of Example 1 before and after exposure to chlorine gas into each extraction solvent, and conduct an experiment of spectroscopic analysis of the extraction solution by extraction time (1.5hr/4.5hr, 4days). , The results are shown in FIG. 2.

Specifically, 10 mL of extraction solvent was added to each of the manual extractor and the color changed after exposure to the chlorine-based disinfectant gas.

In general, before oxidation, o-dianicidin exhibits a maximum absorbance at about 310 nm, and o-dianicidin oxidized due to exposed gas exhibits a maximum absorbance at about 450 nm. Referring to FIG. 2, in the case of acetonitrile, it can be seen that oxidized o-dianisidine is not stable in a solvent, and its absorbance does not show a significant difference from unoxidized o-dianicidin, so it is not suitable as an extraction solvent. have.

On the other hand, isopropyl alcohol shows a clear difference in the absorbance of o-dianicidin before oxidation and oxidized o-dianicidin, and it can be seen that the color change stabilized for 4 days and did not change.

Through this, since it is possible to extract o-dianicidin in a stably oxidized form of isopropyl alcohol, it can be seen that it is suitable as an extraction solvent for measuring the gas exposure amount of the manual extractor according to the present invention.

10,11: dye (benzidine compound) solution
20, 21: description

Claims (14)

materials; And a benzidine compound,
The thickness of the manual extractor is 0.3 to 1.0 mm,
A manual extractor, characterized in that the content of the benzidine compound is on average 0.05 to 0.8 μg/cm ² . The method of claim 1,
The substrate is a manual extractor, characterized in that at least one selected from polydimethylsiloxane (PDMS), polyacrylate (PA), polydimethylsiloxane/divinylbenzene (PDMS/DVB), and polystyrene (PS) polymer. The method of claim 1,
The benzidine compound is a group consisting of o-dianisidine, 3,3'-dimethoxybenzidine, and 3,3'-dichlorobenzidine Manual harvester, characterized in that at least one selected from. The method of claim 1,
A manual extractor, characterized in that the color changes by reacting with a gas having oxidizing ability. The method of claim 4,
The gas having oxidizing ability is a manual extractor, characterized in that chlorine, ozone, oxygen, chlorine dioxide, hydrogen peroxide, and the like. The method of claim 1,
A manual catcher, characterized in that it has the form of a sticker, clip, wristband or name tag. Preparing a dye solution by mixing a benzidine compound with a solvent; And
Including the step of doping the substrate with a benzidine compound by introducing a substrate into the dye solution,
The concentration of the benzidine compound in the dye solution is an average of 0.05 to 0.8 g/L,
The method of manufacturing a manual harvester, characterized in that the thickness of the substrate is 0.3 to 1.0 mm. The method of claim 7,
The substrate is polydimethylsiloxane (PDMS), polyacrylate (PA), polydimethylsiloxane / divinylbenzene (PDMS / DVB), and a method of manufacturing a manual extractor, characterized in that at least one selected from polystyrene (PS) polymer. The method of claim 7,
The benzidine compound is a group consisting of o-dianisidine, 3,3'-dimethoxybenzidine, and 3,3'-dichlorobenzidine A method of manufacturing a manual harvester, characterized in that at least one selected from. The method of claim 7,
Solvents include toluene, acetonitrile, acetone, xylene, dimethylsulfoxide (DMSO), dimethylformamide (DMF), tetrahydrofuran (THF), benzene, ether, methanol, hexane, cyclohexane, pyridine, acetic acid, carbon tetrachloride, Method for manufacturing a manual extractor, characterized in that at least one selected from the group consisting of chloroform, dichloromethane, ethyl acetate and ethylbenzene. The method of claim 7,
The step of doping the benzidine compound on the substrate is a method of manufacturing a manual extractor, characterized in that carried out for 12 to 36 hours at a temperature of 15 to 40 ℃. The method of claim 7,
Method of manufacturing a manual extractor further comprising the step of drying after the step of doping the substrate with the benzidine compound. The method of claim 12,
The step of drying is a method of manufacturing a manual extractor, characterized in that performing for 6 to 36 hours at a temperature of 15 to 50 ℃. A method of measuring the amount of gas leakage using the manual extractor according to claim 1.

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