KR20200130395A - 이량체 항원 수용체(dar) - Google Patents

이량체 항원 수용체(dar) Download PDF

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KR20200130395A
KR20200130395A KR1020207028896A KR20207028896A KR20200130395A KR 20200130395 A KR20200130395 A KR 20200130395A KR 1020207028896 A KR1020207028896 A KR 1020207028896A KR 20207028896 A KR20207028896 A KR 20207028896A KR 20200130395 A KR20200130395 A KR 20200130395A
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sequence
amino acid
heavy chain
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Korean (ko)
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헨리 훙쥔 지
원중 궈
옌량 장
군나르 에프. 카우프만
베이 베이 딩
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소렌토 쎄라퓨틱스, 인코포레이티드
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12N15/62—DNA sequences coding for fusion proteins
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    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • A61K2039/572—Medicinal preparations containing antigens or antibodies characterised by the type of response, e.g. Th1, Th2 cytotoxic response
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
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    • C—CHEMISTRY; METALLURGY
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/00—Fusion polypeptide
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    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
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    • C07K2319/00—Fusion polypeptide
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  • Pharmacology & Pharmacy (AREA)
  • Microbiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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  • Virology (AREA)
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  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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KR1020207028896A 2018-03-09 2019-03-11 이량체 항원 수용체(dar) Ceased KR20200130395A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201862640775P 2018-03-09 2018-03-09
US62/640,775 2018-03-09
PCT/US2019/021681 WO2019173837A1 (en) 2018-03-09 2019-03-11 Dimeric antigen receptors (dar)

Publications (1)

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KR20200130395A true KR20200130395A (ko) 2020-11-18

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KR1020207028896A Ceased KR20200130395A (ko) 2018-03-09 2019-03-11 이량체 항원 수용체(dar)

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US (1) US12180294B2 (https=)
EP (1) EP3762430A4 (https=)
JP (2) JP7542439B2 (https=)
KR (1) KR20200130395A (https=)
CN (1) CN112105649B (https=)
AU (1) AU2019231315A1 (https=)
CA (1) CA3092993A1 (https=)
IL (1) IL277181A (https=)
SG (1) SG11202008568WA (https=)
WO (1) WO2019173837A1 (https=)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022075566A1 (ko) 2020-10-08 2022-04-14 엘티소재주식회사 헤테로고리 화합물, 이를 포함하는 유기 발광 소자, 이의 제조 방법 및 유기 발광 소자의 유기물층용 조성물

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA3080109A1 (en) * 2017-11-03 2019-05-09 Sorrento Therapeutics, Inc. Cd38-directed chimeric antigen receptor constructs
CA3103114A1 (en) * 2018-06-20 2019-12-26 Sorrento Therapeutics, Inc. Variant antibody that binds cd38
CN113825834A (zh) 2019-03-11 2021-12-21 索伦托药业有限公司 使用rna引导的核酸内切酶进行dna构建体整合的改进工艺
JP2022546577A (ja) * 2019-09-05 2022-11-04 ソレント・セラピューティクス・インコーポレイテッド Ｂｃｍａと結合する二量体抗原受容体（ｄａｒ）
JP2023516595A (ja) * 2020-02-27 2023-04-20 ソレント・セラピューティクス・インコーポレイテッド Ｃｄ２０を結合する二量体抗原受容体（ｄａｒ）
EP4139345A1 (en) * 2020-04-24 2023-03-01 Sorrento Therapeutics, Inc. Memory dimeric antigen receptors
WO2022015956A1 (en) 2020-07-15 2022-01-20 Sorrento Therapeutics, Inc. Improved process for dna integration using rna-guided endonucleases
CN116601174A (zh) * 2020-10-12 2023-08-15 索伦托药业有限公司 Cd19定向的嵌合抗原受体构建体
KR20230153529A (ko) * 2021-02-19 2023-11-06 프리트 엠. 쇼드하리 다양한 면역세포를 위한 단일사슬 및 다중사슬 합성 항원 수용체
CN112662631B (zh) * 2021-03-16 2021-06-29 合源生物科技(天津)有限公司 一种car-t细胞灌流培养方法
EP4326292A4 (en) * 2021-04-23 2025-03-26 Vivasor, Inc. Dimeric antigen receptors (dars) that bind gd2
KR20240125982A (ko) * 2021-12-24 2024-08-20 에테하 쭈리히 세포-기반 면역요법을 위한 다중 사슬 항원-특이적 수용체

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7521053B2 (en) * 2001-10-11 2009-04-21 Amgen Inc. Angiopoietin-2 specific binding agents
WO2013044225A1 (en) * 2011-09-22 2013-03-28 The Trustees Of The University Of Pennsylvania A universal immune receptor expressed by t cells for the targeting of diverse and multiple antigens
US9951144B2 (en) * 2015-04-08 2018-04-24 Sorrento Therapeutics, Inc. Antibody therapeutics that bind CD38
WO2016168493A1 (en) 2015-04-15 2016-10-20 Prospect CharterCare RWMC, LLC d/b/a Roger Williams Medical Center Hepatic arterial infusion of car-t cells
EP3842448A1 (en) 2015-05-15 2021-06-30 City of Hope Chimeric antigen receptor compositions
MX2018004721A (es) * 2015-10-23 2018-07-06 Eureka Therapeutics Inc Construcciones quimericas anticuerpo/receptor de celulas t y usos de las mismas.
JP2018537076A (ja) * 2015-10-23 2018-12-20 ソレント・セラピューティクス・インコーポレイテッドＳｏｒｒｅｎｔｏ Ｔｈｅｒａｐｅｕｔｉｃｓ， Ｉｎｃ． プログラム可能な普遍的細胞受容体およびその使用法
WO2017165464A1 (en) * 2016-03-21 2017-09-28 Elstar Therapeutics, Inc. Multispecific and multifunctional molecules and uses thereof
US11116834B2 (en) * 2016-10-19 2021-09-14 City Of Hope Use of endogenous viral vaccine in chimeric antigen receptor T cell therapy
CA3080109A1 (en) 2017-11-03 2019-05-09 Sorrento Therapeutics, Inc. Cd38-directed chimeric antigen receptor constructs
EP3729081B1 (en) 2017-12-21 2025-02-19 F. Hoffmann-La Roche AG Car-t cell assay for specificity test of novel antigen binding moieties
EP3775902B1 (en) 2018-04-04 2023-02-22 F. Hoffmann-La Roche AG Diagnostic assays to detect tumor antigens in cancer patients
EP3775883A1 (en) 2018-04-04 2021-02-17 F. Hoffmann-La Roche AG Diagnostic assays to detect tumor antigens in cancer patients

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2022075566A1 (ko) 2020-10-08 2022-04-14 엘티소재주식회사 헤테로고리 화합물, 이를 포함하는 유기 발광 소자, 이의 제조 방법 및 유기 발광 소자의 유기물층용 조성물

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CA3092993A1 (en) 2019-09-12
CN112105649B (zh) 2025-09-05
US20200399393A1 (en) 2020-12-24
CN112105649A (zh) 2020-12-18
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IL277181A (en) 2020-10-29
JP2023168545A (ja) 2023-11-24
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US12180294B2 (en) 2024-12-31

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