KR20200120668A - 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 - Google Patents
미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 Download PDFInfo
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- KR20200120668A KR20200120668A KR1020207025723A KR20207025723A KR20200120668A KR 20200120668 A KR20200120668 A KR 20200120668A KR 1020207025723 A KR1020207025723 A KR 1020207025723A KR 20207025723 A KR20207025723 A KR 20207025723A KR 20200120668 A KR20200120668 A KR 20200120668A
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
- B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502715—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by interfacing components, e.g. fluidic, electrical, optical or mechanical interfaces
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
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- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
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- G01N33/56966—Animal cells
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- B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
- B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
- B01L3/502746—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the means for controlling flow resistance, e.g. flow controllers, baffles or throttle valves
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
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- G01N15/1459—Optical investigation techniques, e.g. flow cytometry without spatial resolution of the texture or inner structure of the particle, e.g. processing of pulse signals the analysis being performed on a sample stream
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- G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
- G01N15/10—Investigating individual particles
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- G01N15/1484—Optical investigation techniques, e.g. flow cytometry microstructural devices
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/6456—Spatial resolved fluorescence measurements; Imaging
- G01N21/6458—Fluorescence microscopy
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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- B—PERFORMING OPERATIONS; TRANSPORTING
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- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
- B01L2200/06—Fluid handling related problems
- B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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- B01L2300/00—Additional constructional details
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- B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
- B01L2300/0877—Flow chambers
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- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
- B01L2400/00—Moving or stopping fluids
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- B01L2400/084—Passive control of flow resistance
- B01L2400/086—Passive control of flow resistance using baffles or other fixed flow obstructions
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- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
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- G01N2021/6421—Measuring at two or more wavelengths
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- G—PHYSICS
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- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/6428—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes"
- G01N2021/6439—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks
- G01N2021/6441—Measuring fluorescence of fluorescent products of reactions or of fluorochrome labelled reactive substances, e.g. measuring quenching effects, using measuring "optrodes" with indicators, stains, dyes, tags, labels, marks with two or more labels
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- G—PHYSICS
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- G01N2201/02—Mechanical
- G01N2201/022—Casings
- G01N2201/0221—Portable; cableless; compact; hand-held
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- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Analytical Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Dispersion Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Hematology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Clinical Laboratory Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Signal Processing (AREA)
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- Zoology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Wood Science & Technology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Computer Vision & Pattern Recognition (AREA)
- Optical Measuring Cells (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161449840P | 2011-03-07 | 2011-03-07 | |
| US61/449,840 | 2011-03-07 | ||
| PCT/CA2012/000227 WO2012119243A2 (en) | 2011-03-07 | 2012-03-07 | Method and system for cell detection and analysis |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020197002670A Division KR102307064B1 (ko) | 2011-03-07 | 2012-03-07 | 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20200120668A true KR20200120668A (ko) | 2020-10-21 |
Family
ID=46798588
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020207025723A Ceased KR20200120668A (ko) | 2011-03-07 | 2012-03-07 | 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 |
| KR1020137026363A Ceased KR20140039175A (ko) | 2011-03-07 | 2012-03-07 | 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 |
| KR1020217030614A Abandoned KR20220023960A (ko) | 2011-03-07 | 2012-03-07 | 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 |
| KR1020197002670A Expired - Fee Related KR102307064B1 (ko) | 2011-03-07 | 2012-03-07 | 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020137026363A Ceased KR20140039175A (ko) | 2011-03-07 | 2012-03-07 | 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 |
| KR1020217030614A Abandoned KR20220023960A (ko) | 2011-03-07 | 2012-03-07 | 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 |
| KR1020197002670A Expired - Fee Related KR102307064B1 (ko) | 2011-03-07 | 2012-03-07 | 미세유체기술을 이용한 휴대용 세포 검출 및 분석 방법 및 시스템 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20140170679A1 (https=) |
| EP (1) | EP2683810A4 (https=) |
| KR (4) | KR20200120668A (https=) |
| CN (2) | CN107941680A (https=) |
| AU (1) | AU2012225123B2 (https=) |
| BR (1) | BR112013022995A8 (https=) |
| CA (1) | CA2828487C (https=) |
| SG (1) | SG193009A1 (https=) |
| WO (1) | WO2012119243A2 (https=) |
| ZA (1) | ZA201306705B (https=) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102090776B1 (ko) | 2012-07-25 | 2020-03-18 | 테라노스, 인코포레이티드 | 생체시료의 이미지 분석 및 측정 |
| WO2014127372A2 (en) * | 2013-02-18 | 2014-08-21 | Theranos, Inc. | Image analysis and measurement of biological samples |
| US9513224B2 (en) | 2013-02-18 | 2016-12-06 | Theranos, Inc. | Image analysis and measurement of biological samples |
| KR102179088B1 (ko) * | 2013-12-12 | 2020-11-18 | 메스 메디컬 일렉트로닉 시스템즈 리미티드 | 홈 테스팅 장치 |
| CN103954546A (zh) * | 2014-04-30 | 2014-07-30 | 西安理工大学 | 基于光探测器与微流控技术的流式细胞仪 |
| CN104212705B (zh) * | 2014-09-19 | 2016-02-10 | 成都劲宏科技有限公司 | 一种基于脉冲检测技术的双通道细胞微流图像采集系统 |
| US10724069B2 (en) | 2014-09-29 | 2020-07-28 | Chipcare Corporation | Methods and devices for cell detection |
| EP3224594A4 (en) * | 2014-11-28 | 2018-08-08 | Chipcare Corporation | Multiplex bead array assay |
| CN104486549B (zh) * | 2014-12-29 | 2017-07-25 | 中国科学院长春光学精密机械与物理研究所 | 一种用于成像流式细胞仪的高通量拍摄方法 |
| EP3237112B1 (en) | 2015-01-30 | 2021-05-26 | Hewlett-Packard Development Company, L.P. | Vented microfluidic reservoirs |
| CN106153879A (zh) * | 2015-04-08 | 2016-11-23 | 李木 | 用活性微小生物实现疾病诊断的微流控系统及其诊断方法 |
| CN118329854A (zh) * | 2015-10-15 | 2024-07-12 | 卢莫斯诊断Ip股份有限公司 | 用于读出ivd测定的装置 |
| US11698332B2 (en) | 2015-11-24 | 2023-07-11 | Hewlett-Packard Development Company, L.P. | Devices having a sample delivery component |
| JP6529667B2 (ja) | 2016-01-22 | 2019-06-12 | ヒューレット−パッカード デベロップメント カンパニー エル.ピー.Hewlett‐Packard Development Company, L.P. | 検出区域における粒子凝集の制御を備える流体検出 |
| WO2017165852A1 (en) | 2016-03-24 | 2017-09-28 | Biological Dynamics, Inc. | Disposable fluidic cartridge and components |
| US11371941B2 (en) * | 2016-07-04 | 2022-06-28 | Celltool Gmbh | Device and method for the determination of transfection |
| US10768105B1 (en) | 2016-07-29 | 2020-09-08 | Labrador Diagnostics Llc | Image analysis and measurement of biological samples |
| US11802868B2 (en) | 2016-10-17 | 2023-10-31 | Reliant Immune Diagnostics, Inc. | System and method for variable function mobile application for providing medical test results |
| US12009078B2 (en) | 2016-10-17 | 2024-06-11 | Reliant Immune Diagnostics, Inc. | System and method for medical escalation and intervention that is a direct result of a remote diagnostic test |
| US11651866B2 (en) | 2016-10-17 | 2023-05-16 | Reliant Immune Diagnostics, Inc. | System and method for real-time insurance quote in response to a self-diagnostic test |
| US10902951B2 (en) | 2016-10-17 | 2021-01-26 | Reliant Immune Diagnostics, Inc. | System and method for machine learning application for providing medical test results using visual indicia |
| US11107585B2 (en) | 2016-10-17 | 2021-08-31 | Reliant Immune Diagnostics, Inc | System and method for a digital consumer medical wallet and storehouse |
| US11693002B2 (en) | 2016-10-17 | 2023-07-04 | Reliant Immune Diagnostics, Inc. | System and method for variable function mobile application for providing medical test results using visual indicia to determine medical test function type |
| US9857372B1 (en) | 2016-10-17 | 2018-01-02 | Reliant Immune Diagnostics, LLC | Arbovirus indicative birth defect risk test |
| US11579145B2 (en) | 2016-10-17 | 2023-02-14 | Reliant Immune Diagnostics, Inc. | System and method for image analysis of medical test results |
| TWI614500B (zh) * | 2016-11-21 | 2018-02-11 | 國立清華大學 | 細胞檢測晶片的影像定位與拼接方法及影像檢測系統 |
| US10527555B2 (en) | 2016-12-14 | 2020-01-07 | Reliant Immune Disgnostics, Inc. | System and method for visual trigger to perform diagnostic test |
| US11295859B2 (en) | 2016-12-14 | 2022-04-05 | Reliant Immune Diagnostics, Inc. | System and method for handing diagnostic test results to telemedicine provider |
| US11599908B2 (en) | 2016-12-14 | 2023-03-07 | Reliant Immune Diagnostics, Inc. | System and method for advertising in response to diagnostic test |
| US11594337B2 (en) | 2016-12-14 | 2023-02-28 | Reliant Immune Diagnostics, Inc. | System and method for advertising in response to diagnostic test results |
| US11170877B2 (en) | 2016-12-14 | 2021-11-09 | Reliant Immune Diagnostics, LLC | System and method for correlating retail testing product to medical diagnostic code |
| US11125746B2 (en) | 2016-12-14 | 2021-09-21 | Reliant Immune Diagnostics, Inc. | Two-sided flow-through immunoassay |
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