KR20200113070A - Biochip Making System using Roll to Roll - Google Patents

Abstract

A biochip manufacturing system using a roll-to-roll processing according to an aspect of the present invention includes: a system unit that is conveyed by a plurality of rolls and produces a plurality of biochips for examining blood; a cover unit for manufacturing a protective cover attached to an upper part of the biochips by using the plurality of rolls; and a bonding unit for bonding the system unit and the cover unit by a roll-to-roll processing. According to the present invention, it is possible to mass-produce biochips.

Description

Biochip Making System using Roll to Roll}

The present invention relates to a biochip manufacturing system using a roll-to-roll, and more particularly, to a biochip manufacturing system using a roll-to-roll capable of mass-producing a biochip capable of detecting various diseases with blood using a roll-to-roll. .

In general, analysis of fluid samples is widely used in the fields of chemistry and biotechnology, as well as in the field of diagnosis through analysis of blood and body fluids collected from patients. In recent years, in order to perform the analysis of such a fluid sample more simply and efficiently, various kinds of miniaturized analysis and diagnostic equipment and technologies have been developed.

In particular, lab-on-a-chip uses related technologies such as microfluidic mechanics and microfluidic manipulation for various experimental processes performed in the laboratory such as separation, purification, mixing, labeling, analysis, and cleaning of samples. It is operated by using a small motor or capillary phenomenon as a driving force to move the fluid sample through the microchannel formed inside the chip.

Several methods are used in manufacturing such a wrap-on-a-chip, but in the case of a manufacturing method by manufacturing molding, there is a limit to the size and precision of a shape that can be manufactured by machining a mold.

That is, in manufacturing a fine closed channel having a size of less than several tens of microns, it is not easy to uniformly process the corners of the channel without loss, and this may cause problems in standards and quality control during mass production. In addition, such a minute error in the channel structure interferes with fluid flow, resulting in inconsistent analysis results.

In addition, in forming a required shape such as a step or a pillar on a fine channel, it is very difficult to implement an accurate shape of a desired nano- or micro-level.

In addition, since the production of molds by conventional machining takes a long time to produce, it is difficult to proceed with mass production.

The present invention has been conceived to solve the above problems, and an object of the present invention is to provide a biochip manufacturing system using a roll-to-roll capable of mass-producing biochips.

Another object of the present invention is to provide a biochip manufacturing system using a roll-to-roll capable of producing a biochip that requires fine adjustment on a nano scale.

The biochip manufacturing system using a roll-to-roll according to an aspect of the present invention for achieving the above object is transported by a plurality of rolls, a system unit for manufacturing a plurality of biochips for examining blood, and a system unit on top of the biochip. A cover part for manufacturing the attached protective cover by roll-to-roll, and an adhesive part for bonding the system part and the cover part by roll-to-roll.

The biochip may include a supply hole through which blood is supplied, a guide groove through which blood flowing through the supply hole moves, and a plurality of wells in which blood and the reagent are mixed.

The system unit is provided at the center of the winding roll on which the film is wound, and rotates the winding roll to supply the film, and a coating supply unit that supplies a coating material of a transparent material to one surface of the film supplied from the winding roll. And, at least one reagent is injected into the plurality of wells formed in the first compression unit and a first compression unit for generating a body in which the well is formed by pressing the coating material coated in the coating supply unit by roll-to-roll It may be provided with an input unit.

The cover part is provided at the center of the take-up roll on which the film is wound, and rotates the take-up roll to supply the film; and a coating supplier that supplies a coating material to one surface of the film supplied from the take-up roll; and A second compression unit that generates the protective cover by transporting and compressing the coating material coated in the coating supply unit between roll-to-roll and curing it, and supplying an adhesive to one surface of the protective cover transferred from the second pressing unit. A bonding device may be provided.

The coating supply unit includes a surface cleaning device that removes foreign substances and static electricity attached to the surface of the film supplied from the release roll, and a coating device that applies a coating material to one surface of the film whose surface is arranged by the surface cleaning device. , It may be provided with a drying device for drying the coating material formed of a liquid.

The first pressing unit presses the surface of the coating material transferred from the coating supply unit to create a plurality of wells, and a plurality of rolls formed on the surface of the system roll with different lengths depending on the depth of the plurality of wells. It may be provided with a projection of the, a transfer roll provided at a position corresponding to the system roll to transfer the film, and a curing device for curing the body in which the plurality of the wells are produced.

The injection unit includes a reagent injection device for injecting at least one reagent into the plurality of wells formed in the main body by the compression unit, and a reagent drying device for drying the reagent injected into the biochip transferred from the reagent supply device. can do.

The bonding unit includes a bonding device for attaching the body manufactured by the system unit and the protective cover on which the adhesive is applied by a roll-to-roll, and a UV drying device for drying the adhesive through the film transferred from the bonding device. A device and a cutting device for cutting the biochip and the film to which the protective cover is attached may be provided.

The cutting device may create a supply hole through which the blood is supplied through a portion of the biochip to which the protective cover is attached.

According to the biochip manufacturing system using a roll-to-roll according to the present invention, a film is transferred by a roll-to-roll and a coating material is applied on the top to generate a biochip pattern, thereby enabling mass production of biochips.

1 is a perspective view showing a biochip manufacturing system using a roll-to-roll according to an embodiment of the present invention.
2 to 3 are cross-sectional views showing a biochip manufacturing system using the roll-to-roll shown in FIG. 1.
4 is a cross-sectional view showing a system unit according to an embodiment of the present invention.
Figure 5 is a cross-sectional view showing a cover according to an embodiment of the present invention.
6 is a cross-sectional view showing an adhesive part according to an embodiment of the present invention.
7 is a perspective view showing a biochip according to an embodiment of the present invention.
8 is an exploded perspective view showing the biochip shown in FIG. 7.
9 is a flow chart showing a method of manufacturing a biochip using a roll-to-roll according to another embodiment of the present invention.

Hereinafter, a biochip manufacturing system using a roll-to-roll according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings.

1 is a perspective view showing a biochip manufacturing system using a roll-to-roll according to an embodiment of the present invention, and FIGS. 2 to 3 are cross-sectional views illustrating the biochip manufacturing system using the roll-to-roll shown in FIG. 1.

1 to 3, the biochip manufacturing system using a roll-to-roll according to an embodiment of the present invention is transported by a plurality of rolls, and a system unit for manufacturing a plurality of biochips 10 for examining blood ( 100), a cover portion 200 for manufacturing the protective cover 40 attached to the upper portion of the biochip 10 by a plurality of rolls, and the system portion 100 and the cover portion 200 roll-to-roll It may be provided with an adhesive portion 300 to be bonded by.

The biochip manufacturing system using roll-to-roll transfers the film 20 having the flexibility secured by roll-to-roll, and after coating the coating material 70 on one side of the transferred film 20, the biochip 10 is placed thereon. It can be created by attaching the protective cover 40 to the generated body 30. Therefore, as blood is supplied, the blood and the reagent 60 are mixed, so that the medical biochip 10 can be mass-produced to know the presence or progress of various diseases such as cancer.

As shown in FIGS. 4 to 5, the biochip 10 includes a supply hole 11 through which blood is supplied, a guide groove 12 through which blood flowing through the supply hole 11 moves, and the guide A plurality of wells 13 in which blood moving through the groove 12 and the reagent 60 are mixed may be provided.

The supply hole 11 may pass through the biochip 10 and the protective cover 40 attached to the top of the biochip 10 to have a predetermined size. When blood is dropped, a plurality of It is supplied to the well 13. At this time, blood supplied to the supply hole 11 is absorbed through the guide groove 12.

The supply hole 11 may be formed by penetrating the lower film 20 of the biochip 10, but when the blood supplied to the biochip 10 is not released to the outside, the film 20 may not penetrate. .

The guide groove 12 may be a plurality of passages connected to the supply hole 11 and the plurality of wells 13, and the plurality of wells 13 are formed deeper than the guide groove 12 to form the well 13 When the supplied blood moves through the guide groove 12, it may be filtered.

A number of wells 13 are formed as 224, but the quantity may vary in various ways, and a reagent 60 is added to the well 13 to determine various diseases by light emitted as blood and reagents 60 are mixed. can do.

The well 13 is formed in a circular shape, but may be variously formed depending on the purpose of use and the amount of blood.

6, the system unit 100 is formed of an embossing and printing module, the film 20 is provided at the center of the winding roll 50 to rotate the winding roll 50 and the film A coating supply unit 120 supplying a coating material 70 made of a transparent material to one side of the release roll 110 supplied from the release roll 110 and the film 20 supplied from the release roll 110, and the coating supply unit The coating material 70 coated in 120 is compressed by roll-to-roll to create a body 30 in which the well 13 is manufactured, and the first compression unit 130 An input unit 140 for inserting at least one reagent 60 into the plurality of wells 13 manufactured in may be provided.

The take-up roll 50 may be rotated and released by the unwinding roll 110, and may be formed of a flexible and thin material because fluidity is secured so that it can be transferred in a roll-to-roll device. In addition, the film 20 may be formed to have a predetermined length or may be formed to be long so as to move without being cut off in the roll-to-roll device.

The film 20 coated on the winding roll 50 may be formed of at least one of a PEN (polyethylene naphthalate) film 20 and PET, and is formed of a transparent silicone material so that the luminescence of blood can be visually confirmed. .

The coating supply unit 120 includes a surface cleaning device 121 that removes foreign substances and static electricity attached to the surface of the film 20 supplied from the release roll 110, and the surface is A coating device 122 for applying the coating material 70 to one surface of the arranged film 20 and a drying device 123 for drying the coating material 70 formed of a liquid may be provided.

The coating material 70 coated on the surface of the film 20 in the coating supply unit 120 may be formed of at least one of a PEN (polyethylene naphthalate) film 20 and PET, as in the film 20. Can be applied.

Before the coating material 70 is applied to the film 20, the foreign material may be removed or static electricity may be removed from the film 20 by the surface cleaning device 121. At this time, the surface cleaning device 121 can be cleaned by supplying a gaseous cleaning material (Plasma) or cutting the surface of the film 20 or supplying wind to make the surface of the film 20 even at the bottom. have.

At this time, when the gaseous cleaning material is supplied, the gaseous cleaning material may be evenly attached to the surface cleaning device 121 at a high temperature on one surface of the film 20. 121) is formed of a plasma processor, an ionizer, an antistatic bar, etc., and can pretreat the material surface and remove static electricity. In addition, in the case of plasma treatment, since plasma gas adheres to the surface of the material, cleaning materials may be attached.

The coating device 122 may apply a coating material 70 forming the biochip 10 on one surface of the film 20 transferred from the surface cleaning device 121. As the coating material 70 is formed in a liquid state, it may be applied by the coating device 122, and the amount of the coating material 70 applied by the coating device 122 varies depending on the width and thickness of the biochip 10. I can.

In this case, the coating material 70 applied by the coating device 122 is applied on the upper portion of the film 20 transferred by the roll-to-roll device, and the coating material 70 must be supplied in a fixed amount.

The drying device 123 can dry the coating material 70 applied by the coating device 122 with a liquid and cure it to a predetermined size, and the temperature of the drying device 123 is variously controlled.

The first compression unit 130 penetrates between the system roll 131 and the transfer roll 133 provided on the upper and lower portions of the cured coating material 70, respectively, and a plurality of wells 13 are provided on the upper portion of the coating material 70. ) To create the body 30 is produced.

The first compression unit 130 as described above is a system roll 131 for generating a plurality of wells 13 by pressing or printing the surface of the coating material 70 transferred from the coating supply unit 120, and the A plurality of protrusions 132 formed on the surface of the system roll 131 with different lengths according to the depth of the plurality of wells 13, and the film 20 are provided at positions corresponding to the system roll 131 ) And a curing device 134 for curing the main body 30 on which the plurality of wells 13 are produced.

The system roll 131 may be spaced apart to have the same thickness as the biochip 10 on the top of the transfer roll 133, and the coating material 70 to be transferred with a size and weight larger than that of the transfer roll 133 It is possible to create a plurality of wells 13 and guide grooves 12 on the top of.

At this time, a plurality of wells 13 and protrusions 132 equal to the depth of the guide groove 12 may be provided on the outer surface of the system roll 131, and as the system roll 131 rotates, the well 13 ) Is created.

In addition, the protrusions 132 may protrude to the outside of the system roll 131 in various lengths to create a plurality of wells 13 and guide grooves 12 in the coating material 70, and the system roll 131 is a coating material. When (70) is pressed, the body 30 in which the well 13 and the guide groove 12 are formed by the protrusion 132 is created.

The curing device 134 is transferred from one surface of the film 20 and cures the body 30 in which the well 13 and the guide groove 12 are formed in the coating material 70 by the protrusion 132 to cure the biochip 10 ) Can be maintained. As such a curing device 134 wraps the system roll 131 or is provided at a position corresponding to the system roll 131 to cure the coating material 70 in a state in which the projections 132 are inserted into the coating material 70 The shape of the body 30 can be maintained without changing the shape.

As such, the first compression unit 130 is basically a process of engraving a desired pattern using heat, pressure, and gap. At this time, the film 20 must have a heat source capable of processing only the reagent by applying heat within a range that does not damage the film 20, and pressure must be applied to prevent restoration while maintaining an appropriate depth. The gap needs to be adjusted to prevent the occurrence of.

The pressure and the gap are in a relative position.Therefore, a phenomenon occurs that the pressure decreases to increase the pressure of the reagent pressed, and the pressure decreases to increase the pressure again, so understand the correlation between the pressure and the gap at an appropriate level. Make sure you are satisfied.

In addition, it is necessary to soften the reagent by applying heat of an appropriate temperature so that the well 13 can be generated smoothly.

The injection unit 140 may inject the reagent 60 into the well 13 of the biochip 10 by the first compression unit 130. The reagent 60 may be replaced with various reagents 60 that are mixed with blood and emit light.

The injection unit 140 includes a reagent injection device 141 for injecting at least one reagent 60 into the plurality of wells 13 formed in the main body 30 from the compression unit, and the reagent injection device ( A reagent drying device 142 for drying the reagent 60 injected into the biochip 10 transferred from 141 may be provided.

The reagent injection device 141 is provided so as to be spaced apart from the top of the film 20, and the reagent 60 may be injected into the well 13 of the main body 30 transported together with the film 20. At this time, the reagent injection device 141 accurately injects the reagents 60 into the plurality of wells 13 as they are spaced apart at intervals similar to the thickness of the biochip 10.

In the reagent injection device 141, a plurality of holes are formed in the long side of the main body 30 in order to inject the reagent 60 into a plurality of wells 13 that are provided in a plurality of the entire main body 30. In addition, the reagent injection device 141 has a valve for supplying and shutting off the reagent 60 so that the reagent 60 is injected into the main body 30 arranged at equal intervals in the film 20, and the reagent 60 is not injected into the guide groove 12. It is equipped.

The reagent drying device 142 supplies heat of various temperatures from the lower end of the coating material 70 when the main body 30 into which the reagent 60 is injected is transferred so that the reagent 60 can be seated on the main body 30. .

When the reagent 60 is seated in the well 13 in this way, the film 20 to which the main body 30 is attached may be transferred to the adhesive part 300.

Referring to FIG. 7, the cover part 200 is provided at the center of the take-up roll 50 on which the film 20 is wound, rotates the take-up roll 50, and supplies the film 20. (110), a coating supply unit 120 for supplying a coating material 70 to one surface of the film 20 supplied from the pulling roll 110, and the coating material 70 coated by the coating supply unit 120 The second compression portion 210 that generates the protective cover 40 by conveying and compressing it between rolls and rolls and curing it, and one side of the protective cover 40 transferred from the second pressing portion 210 It may be provided with a bonding device 220 for supplying the adhesive 80 to the.

The unwinding roll 110 may be guided to the coating supply unit 120 by supplying the winding roll 50 in the same manner as the system unit 100.

The coating supply unit 120 includes a surface cleaning device 121 that removes foreign substances and static electricity attached to the surface of the film 20 supplied from the release roll 110 in the same manner as the system unit 100, and the A coating device 122 for applying a coating material 70 to one surface of the film 20 on which the surface is arranged in a surface arrangement device 121, and a drying device 123 for drying the coating material 70 formed of a liquid. Can be equipped.

In this way, the coating material 70 coated by the coating supply unit 120 is formed of the same material as the biochip 10 generated in the system unit 100, but is formed to have a thinner thickness than the biochip 10. In addition, the thickness of the protective cover 40 can be adjusted by the transfer roll 133 and the pressing roll 211 of the second pressing unit 210, and the thickness of the protective cover 40 is maintained. The transferred coating material 70 is cured while maintaining its shape by the curing device 134.

In addition, the protective cover 40 may have a plurality of air holes so as to smoothly supply blood to the plurality of wells 13. Accordingly, as in the system roll 131, the pressing roll 211 is provided with microscopic protrusions so that an air hole may be formed when the protective cover 40 is cured.

At this time, the fine protrusions form air holes only in the coating material 70 and prevent the film 20 from being damaged.

The bonding device 220 may supply the adhesive 80 to the outside of one surface of the protective cover 40 transferred from the second compression unit 210. The bonding device 220 may be provided on the edge of the protective cover 40 so that the adhesive 80 does not flow into the well 13 and the guide groove 12 when the protective cover 40 and the biochip 10 contact each other. .

When the adhesive 80 is applied to the protective cover 40 in this way, the protective cover 40 may be transferred to the adhesive part 300.

8, the bonding unit 300 is a bonding device for attaching the biochip 10 manufactured by the system unit 100 and the protective cover 40 to which the adhesive 80 is applied by a roll-to-roll (310), a UV drying device 320 through which the film 20 transferred from the bonding device 310 is passed, and drying the adhesive 80, and the biochip to which the protective cover 40 is attached 10 and a cutting device 330 for cutting the film 20 and a take-up roll 50 for winding the film 20 on which the biochip 10 is cut.

The bonding device 310 may be attached by positioning the biochip 10 transferred from the system unit 100 and the protective cover 40 to which the adhesive 80 transferred from the cover unit 200 is applied to match each other. . At this time, the bonding device 310 is provided with rolls at the top and bottom, so when the biochip 10 and the protective cover 40 penetrate therebetween, the biochip 10 and the protective cover 40 are attached.

In addition, the biochip 10 and the protective cover 40 may be formed to have a thickness of the completed biochip 10 by penetrating the bonding device 310.

In addition, the bonding device 310 is supplied with heat to increase the adhesive strength between the biochip 10 and the protective cover 40.

The UV drying device 320 may increase the bonding strength of the adhesive 80 by drying with UV light from the top and bottom when the biochip 10 and the protective cover 40 are combined and then transferred.

The cutting device 330 may cut the biochip 10 and the film 20 after the biochip 10 and the protective cover 40 are combined. Since the biochip 10 and the protective cover 40 are formed to increase in width and size as they pass through the roll-to-roll during the manufacturing and bonding process, the cutting device 330 can cut them to an accurate size. In addition, as the biochip 10 and the protective cover 40 are transferred from one side of the film 20, the film 20 can be cut at the same time.

Such a cutting device 330 is formed as a roll-to-roll with rolls at the top and bottom, and is formed so that the blade protrudes at the top so that when the biochip 10 and the protective cover 40 are combined between the rolls and rolls, It can be cut to the correct size.

In addition, the cutting device 330 may pass through a portion of the biochip 10 to which the protective cover 40 is attached to create a supply hole 11 through which blood is supplied. In this case, the length of the cutting device 330 may be adjusted so that it does not penetrate to the lower film 20.

In addition, the biochip 10 cut by the cutting device 330 may be transferred by the cutting device 330 and then dropped downward and separated.

In addition, as the film 20 from which the biochip 10 is separated is wound and formed into a winding roll 50, it may be recycled or discarded.

In this way, when mass production of the biochip 10 using a roll-to-roll, a control device may be further provided so that the speed and position are not changed when the film 20 and the coating material 70 such as tension, registry, etc. are transferred. The protrusion 132 is created in the coating material 70 at the correct position by the control device, and the reagent 60 can be injected into the plurality of wells 13, and the protective cover 40 is attached to the upper part of the main body 30. do. In addition, when cutting the biochip 10 by the cutting device 330, the sizes and cutting positions of the plurality of biochips 10 are adjusted to match.

In the following description of a method of manufacturing a biochip using a roll-to-roll according to another embodiment of the present invention, the same reference numerals are used for the same configuration as the biochip manufacturing system using a roll-to-roll according to the above-described embodiment, and Detailed description is omitted.

9 is a flow chart showing a method of manufacturing a biochip using a roll-to-roll according to another embodiment of the present invention.

Step S1100 may be dried by applying the coating material 70 to the film 20 in the system unit 100.

At this time, the film 20 may be provided with a surface cleaning device 121 for removing foreign substances and static electricity before the coating material 70 is applied, and the coating material 70 is applied from the coating supply unit 120 to be coated. I can. In addition, the coating material 70 applied by the coating supply unit 120 may be dried in the drying device 123.

Step S1200 generates a plurality of wells 13 by compressing the dried coating material 70 in the first compression unit 130.

The first compression unit 130 compresses the surface of the coating material 70 transferred from the coating supply unit 120 to generate a plurality of the wells 13, and the system roll 131 A plurality of protrusions 132 formed in different lengths according to the depth of the plurality of wells 13 on the surface of the system, and a transfer to transport the film 20 provided at a position corresponding to the system roll 131 A roll 133 and a curing device 134 for curing the main body 30 on which the plurality of wells 13 are manufactured may be provided.

In step S1300, the reagent 60 may be added to the plurality of wells 13 of the main body 30 generated by the first compression unit 130.

The reagent 60 transfers the reagent injection device 141 and the reagent drying device 142 of the input unit 140 and may be introduced into a plurality of wells 13.

In step S2100, the coating material 70 may be applied to the film 20 in the cover part 200 and dried.

At this time, the film 20 may be unwound by the unwinding roll 110, and a surface cleaning device 121 that removes foreign substances and static electricity attached to the surface of the film 20 supplied from the unwinding roll 110 Wow, a coating device 122 for applying a coating material 70 to one surface of the film 20 on which the surface is arranged in the surface cleaning device 121, and a drying device for drying the coating material 70 formed of a liquid It may be dried in the coating supply unit 120 having (123).

Step S2200 may form the thickness of the protective cover 40 by compressing the dried coating material 70 in the second compression unit 210.

The thickness of the protective cover 40 can be adjusted by the transfer roll 133 and the compression roll 211 of the second compression unit 210, and the thickness of the protection cover 40 is maintained and transferred. The coating material 70 is cured while maintaining its shape by the curing device 134.

In addition, the protective cover 40 may have a plurality of air holes so that blood is smoothly supplied to the plurality of wells 13. As a result, when the pressing roll 211 is provided with microscopic protrusions, when the protective cover 40 is cured, an air hole may be formed.

In step S2300, the adhesive 80 may be applied to one surface of the protective cover 40 by the bonding device 220.

The bonding device 220 may supply the adhesive 80 to the outside of one surface of the protective cover 40 transferred from the second compression unit 210. The bonding device 220 may be provided on the edge of the protective cover 40 so that the adhesive 80 does not flow into the well 13 and the guide groove 12 when the protective cover 40 and the biochip 10 contact each other. .

In step S3100, the body 30 and the protective cover 40 in which the plurality of wells 13 are formed may be attached in the bonding device 310 of the bonding part 300.

The bonding device 310 may be attached by positioning the biochip 10 transferred from the system unit 100 and the protective cover 40 to which the adhesive 80 transferred from the cover unit 200 is applied to match each other. . At this time, the bonding device 310 is provided with rolls at the top and bottom, so when the biochip 10 and the protective cover 40 penetrate therebetween, the biochip 10 and the protective cover 40 are attached.

In step S3200, the biochip 10 attached by the bonding device 310 may be dried with the UV drying device 123.

The UV drying device 320 increases the bonding strength of the adhesive 80 or increases the bonding strength of the adhesive 80 by drying with UV light from the top and bottom when the biochip 10 and the protective cover 40 are combined and then transferred. It is preferable to use it as an adhesive and to adjust the adhesive performance by curing with UV light, but in the present disease, adhesion without an adhesive is possible due to the characteristics of PDMS.

In step S3300, the dried biochip 10, the protective cover 40, and the film 20 may be cut by the cutting device 330.

The cutting device 330 may cut the biochip 10 and the film 20 after the biochip 10 and the protective cover 40 are combined. Since the biochip 10 and the protective cover 40 are formed to increase in width and size as they pass through the roll-to-roll during the manufacturing and bonding process, the cutting device 330 can cut them to an accurate size. In addition, as the biochip 10 and the protective cover 40 are transferred from one side of the film 20, the film 20 can be cut at the same time.

In addition, the cutting device 330 may pass through a portion of the biochip 10 to which the protective cover 40 is attached to create a supply hole 11 through which blood is supplied. In this case, the length of the cutting device 330 may be adjusted so that it does not penetrate to the lower film 20.

In step S3400, the cut biochip 10 transferred from the cutting device 330 falls downward and may be separated from the film 20.

In the above, a biochip manufacturing system using a roll-to-roll according to an embodiment of the present invention has been described, but the spirit of the present invention is not limited to the embodiment presented herein. And, those skilled in the art who understand the spirit of the present invention will be able to easily propose other embodiments by adding, changing, deleting, or adding components within the scope of the same idea, but this is also within the scope of the present invention. I would say that

10: biochip 11: supply hole
12: guide groove 13: well
20: film 30: main body
40: protective cover 50: winding roll
60: reagent 70: coating material
80: adhesive 100: system unit
110: feed roll 120: coating supply unit
121: surface cleaning device 122: coating device
123: drying device 130: first compression unit
131: system roll 132: protrusion
133: transfer roll 134: curing device
140: input unit 141: reagent injection device
142: reagent drying device 200: cover
210: second pressing portion 211: pressing roll
220: bonding device 300: bonding unit
310: bonding device 320: UV drying device
330: cutting device

Claims (9)

A system unit that is transported by a plurality of rolls and produces a number of biochips for examining blood,
A cover part for manufacturing the protective cover attached to the top of the biochip by roll-to-roll,
Biochip manufacturing system using a roll-to-roll, including an adhesive portion for bonding the system portion and the cover portion by a roll-to-roll.
The method of claim 1,
The biochip includes a supply hole through which blood is supplied,
A guide groove through which blood flowing through the supply hole moves,
A biochip manufacturing system using a roll-to-roll, comprising: a plurality of wells in which blood moving through the guide groove and the reagent are mixed.
The method of claim 2,
The system unit is provided at the center of a winding roll on which the film is wound, and rotates the winding roll to supply the film;
A coating supply unit for supplying a coating material of a transparent material to one side of the film supplied from the pulling roll,
A first compression unit for generating a body in which the well is formed by pressing the coating material coated by the coating supply unit by roll-to-roll;
A biochip manufacturing system using a roll-to-roll, comprising: an injection unit for introducing at least one reagent into the plurality of wells formed in the first compression unit.
The method of claim 2,
The cover part is provided at the center of the winding roll on which the film is wound, and rotates the winding roll to supply the film;
A coating supply unit for supplying a coating material to one surface of the film supplied from the pulling roll,
A second compression unit for generating the protective cover by conveying the coating material coated in the coating supply unit between rolls to roll, compressing it, and curing it,
A biochip manufacturing system using a roll-to-roll, comprising: a bonding device for supplying an adhesive to one surface of the protective cover transferred from the second pressing unit.
The method of claim 3 or 4,
The coating supply unit includes a surface cleaning device that removes foreign substances and static electricity attached to the surface of the film supplied from the release roll,
A coating device for applying a coating material to one surface of the film, the surface of which is arranged in the surface arrangement device,
Biochip manufacturing system using a roll-to-roll, characterized in that it comprises a drying device for drying the coating material formed of a liquid.
The method of claim 3,
The first compression unit presses the surface of the coating material transferred from the coating supply unit to create a plurality of the wells system roll,
A plurality of protrusions formed on the surface of the system roll having different lengths according to the depths of the plurality of wells,
A transfer roll provided at a position corresponding to the system roll to transfer the film,
A biochip manufacturing system using a roll-to-roll, comprising: a curing device for curing the body in which the plurality of wells are produced.
The method of claim 3,
The injection unit is a reagent injection device for injecting at least one reagent into the plurality of wells formed in the main body by the compression unit,
A biochip manufacturing system using a roll-to-roll, comprising: a reagent drying device for drying the reagent injected into the biochip transferred from the reagent supply device.
The method of claim 2,
The bonding unit is a bonding device for attaching the body manufactured by the system unit and the protective cover coated with the adhesive by a roll-to-roll,
A UV drying device through which the film transferred from the bonding device is passed through and drying the adhesive,
A biochip manufacturing system using a roll-to-roll, comprising: a cutting device for cutting the biochip and the film to which the protective cover is attached.
The method of claim 8,
The cutting device is a biochip manufacturing system using a roll-to-roll, characterized in that through a part of the biochip to which the protective cover is attached to create a supply hole through which the blood is supplied.

Images