KR20200109777A - Intubation and imaging device for inhalation experiment - Google Patents

Abstract

An intubation and imaging device for an inhalation experiment according to an embodiment comprises: a cannula which is inserted into a specimen; an administration unit which has a part received into the cannula, and supplies a sample into the body of the specimen; an imaging unit which has a part received in the cannula and acquires an image in the body of the specimen; a guide unit which is received in the cannula and guides the moving direction of the cannula; and a control unit which controls the supply of the sample from the administration unit or controls an operation of the guide unit. According to the present invention, the administration unit sprays a power-type sample inside the specimen by pneumatic pressure, and the imaging unit is flexibly movable into the specimen according to an operation of the guide unit.

Description

Intubation and imaging device for inhalation experiments {INTUBATION AND IMAGING DEVICE FOR INHALATION EXPERIMENT}

An intubation and imaging device for an inhalation experiment is disclosed, and more particularly, a microintubation and a flexible movable imaging device for inhalation toxicity studies are disclosed.

Today, the benefits and convenience of life are being provided through nanotechnology. However, since ultra-fine nanoparticles are inhaled and can move in the body without being filtered by organs of the human body, there is a risk of biotoxicity. In addition, through cases such as accumulation in the body and causing central nervous system disorders, the harmfulness of the human body to fine particles has been a lot of controversy. In order to evaluate the inhalation toxicity and medicinal efficacy of these fine particles on a living subject, a system in which fine particles are directly administered to a test subject must be established. In addition, an image-based microintubation system is used to administer the liquid or powder test substance used at this time into the airway or esophagus of the test subject.

As a related technology, Korean Patent Application Publication No. 10-2012-0050802 filed on November 11, 2010 discloses a “burn drop dispenser”.

An object according to an embodiment is to provide an apparatus for easily securing an airway or esophagus of a test object through an image.

An object according to an embodiment is to provide an apparatus for easily injecting fine particles into a body of a test specimen using an air injection method.

An object according to an embodiment is to provide an apparatus for injecting fine particles of a certain concentration at a constant air pressure.

An object according to an embodiment is to provide an apparatus for injecting fine particles in a powder form into a body of a test specimen.

An object according to an embodiment is to provide a device that is provided as a soft imaging device and has an unlimited depth of intubation.

An object according to an embodiment is to prevent bleeding and perforation of the tissue during intubation.

An object according to an embodiment is to provide a device capable of injecting microparticles through self-breathing in synchronization with the breathing of a test subject.

Problems to be solved in the embodiments are not limited to the problems mentioned above, and other problems that are not mentioned will be clearly understood by those skilled in the art from the following description.

An intubation and imaging apparatus for an inhalation experiment according to an embodiment for achieving the above object includes: an intubation inserted into a test body; An administration unit that is partially accommodated in the intubation and supplies a sample into the body of the test body; A photographing unit that is partially accommodated in the intubation and obtains an image of the test body in the body; A guide part accommodated in the intubation and guiding a moving direction of the intubation; And a control unit for controlling the sample supply of the administration unit or the operation of the guide unit, wherein the administration unit injects a powdered sample into the test body by pneumatic pressure, and the photographing unit flexibly enters the test body according to the operation of the guide unit. You can move.

According to one side, the guide unit, the temperature is changed by the application of the current from the control unit, the shape is deformed or restored according to the temperature, and the movement direction of the intubation is controlled by the shape change to move the intubation to a desired position. Can enter.

According to one side, it further comprises a breathing sensor for detecting the inhalation or exhalation state of the test object, and the control unit controls to automatically spray the sample when the test object is in an inhaled state by receiving a respiratory signal from the breathing sensor. I can.

According to one side, the administration unit, the storage member for storing the sample in the form of a powder therein; A spray nozzle disposed inside the intubation and having one end connected to the storage member; And an air injection pump connected to the storage member and injecting air, wherein a sample in the storage member is moved to the injection nozzle by air pressure from the air injection pump, and the sample is a test body through the injection nozzle. Can be sprayed into the body.

According to one side, the control unit includes an air injection switch for controlling the drive of the air injection pump, the air injection switch is electrically connected to the storage member, the injection nozzle and the air injection pump, the air By an injection switch, the air injection pump is driven to generate pneumatic pressure in the storage member, the storage member is opened to transfer the stored sample to the injection nozzle, and the injection nozzle is opened to inject the sample to the outside. I can.

According to one side, in the storage member, one end of the injection nozzle may be connected to one surface and one end of the air injection pump may be connected to the other surface.

According to one side, in the storage member, the injection nozzle and the air injection pump may be connected on the same plane of the storage member.

According to the intubation and imaging device for an inhalation experiment according to an embodiment, there is an effect of easily securing the airways or esophagus of a test object through an image.

According to the intubation and imaging apparatus for inhalation experiments according to an embodiment, there is an effect of injecting fine particles into the body of the test object simply by using an air injection method.

According to the intubation and imaging apparatus for an inhalation experiment according to an embodiment, there is an effect of injecting fine particles of a predetermined concentration at a constant air pressure.

According to the intubation and imaging apparatus for inhalation experiments according to an embodiment, there is an effect of injecting fine particles in the form of powder into the body of the test body.

According to the intubation and imaging device for an inhalation experiment according to an embodiment, it is provided as a soft imaging device and the depth of intubation is not limited.

According to the intubation and imaging apparatus for an inhalation experiment according to an embodiment, there is an effect of preventing bleeding and perforation of tissues from occurring during intubation.

According to the intubation and imaging device for an inhalation experiment according to an embodiment, it is possible to inject microparticles through self-breathing in synchronization with the breathing of the test object.

The effects of the intubation and imaging device for inhalation experiments according to an embodiment are not limited to those mentioned above, and other effects not mentioned will be clearly understood by those skilled in the art from the following description.

1 shows an intubation and imaging device for an inhalation experiment according to an embodiment.
2 shows the interior of the intubation and intubation of the imaging device for an inhalation experiment according to an embodiment.
3A illustrates an example of a storage member of an intubation and imaging device for an inhalation experiment according to an embodiment.
3B shows another example of a storage member of an intubation and imaging device for an inhalation experiment according to an embodiment.
4 shows a control signal of a breathing sensor of an intubation and imaging apparatus for an inhalation experiment according to an embodiment.
The following drawings attached to the present specification illustrate a preferred embodiment of the present invention, and serve to further understand the technical idea of the present invention together with the detailed description of the present invention. It is limited and should not be interpreted.

Hereinafter, embodiments will be described in detail through exemplary drawings. In adding reference numerals to elements of each drawing, it should be noted that the same elements are assigned the same numerals as possible even if they are indicated on different drawings. In addition, in describing the embodiment, if it is determined that a detailed description of a related known configuration or function interferes with the understanding of the embodiment, the detailed description thereof will be omitted.

In addition, in describing the constituent elements of the embodiment, terms such as first, second, A, B, (a), (b) may be used. These terms are only used to distinguish the component from other components, and the nature, order, or order of the component is not limited by the term. When a component is described as being "connected", "coupled" or "connected" to another component, that component may be directly connected or connected to that other component, but another component between each component It should be understood that may be “connected”, “coupled” or “connected”.

Components included in one embodiment and components including common functions will be described using the same name in other embodiments. Unless otherwise stated, descriptions in one embodiment may be applied to other embodiments, and detailed descriptions in the overlapping range will be omitted.

1 shows an intubation and imaging device 10 for an inhalation experiment according to an embodiment.

2 shows the interior of the intubation 100 of the intubation and imaging apparatus 10 for an inhalation experiment according to an embodiment.

3A shows an example of the storage member 220 of the intubation and imaging device 10 for an inhalation experiment according to an embodiment.

3B shows another example of the storage member 220 of the intubation and imaging device 10 for an inhalation experiment according to an embodiment.

4 shows a control signal of a breathing sensor of the intubation and imaging device 10 for an inhalation experiment according to an embodiment.

1 and 2, the intubation and imaging apparatus 10 for an inhalation experiment according to an embodiment includes an intubation 100, an administration unit 200, a photographing unit 300, a guide unit 400, and a control unit. (Not shown) and a breathing sensor (not shown) may be included.

The intubation 100 may be provided to be inserted into an internal organ of a test body to inject a sample for an inhalation experiment.

Hereinafter, a case where the intubation 100 enters the body of the test body through the airway of the test body and is inserted into the lung to inject the sample into the lung area of the test body will be described as an example.

For example, the intubation 100 may be extendable in the longitudinal direction to facilitate entry from the airways to the lungs. In addition, it may be provided to be able to move flexibly according to the internal shape of the test object. At this time, the intubation 100 may be made of a soft material. The feature of the intubation 100 described above is to not limit the depth of the intubation, and when the intubation 100 is inserted into the test body, it is also to not cause bleeding or perforation in the airway of the test body.

The administration unit 200 is partially accommodated in the intubation 100 and may supply a sample into the body of the test object.

Specifically, the administration unit 200 may include an injection nozzle 210, a storage member 220, and an air injection pump 230.

Referring to FIG. 2, the spray nozzle 210 extends in the longitudinal direction and may be provided to spray a sample to the outside. In this case, both ends of the spray nozzle 210 may be opened or closed by an electrical signal.

Meanwhile, the injection nozzle 210 may be disposed to be accommodated in the intubation 100. In this case, the diameter of the injection nozzle 210 may be smaller than the diameter of the intubation 100.

In addition, the injection nozzle 210 that is accommodated and moved in the intubation 100 described above may be provided to be flexibly moved according to the internal shape of the test object in order to facilitate entry from the airways to the lungs. In this case, the spray nozzle 210 may likewise be made of a soft material.

Referring to FIG. 1, the storage member 220 may be provided to store a sample therein. In this case, the storage member 220 may store a sample in the form of a powder, but is not limited thereto, and may store a sample in a liquid or gas form if necessary.

In this specification, an intubation and imaging device 10 for an inhalation experiment in which a sample in the form of a powder is stored in the storage member 220 will be described as an example.

In the case of a device capable of spraying a liquid sample obtained by dissolving fine particles in a powder form in water, the characteristics of the powder sample may be different from the desired characteristics. In addition, it also implies the possibility of moving to an unintended path within the body of the test object after being injected due to the influence of osmotic pressure.

On the other hand, the intubation and imaging device 10 for inhalation experiments capable of injecting a sample in the form of a powder is capable of administering a solid powder of a quantity of fine particles, so that the characteristic of the sample may appear in the body of the test object.

Referring to FIG. 3A, the storage member 220 may have a structure in which one end of the spray nozzle 210 is connected to one surface and one end of the air injection pump 230 is connected to the other surface.

Specifically, the inlet and outlet of the storage member 220 may be disposed on different sides. In this case, the outlet of the storage member 220 may communicate with the inlet of the spray nozzle 210, and the inlet of the storage member 220 may communicate with the air injection pump 230.

In addition, the storage member 220 as illustrated in FIG. 3A may have the same direction of air injection and sample discharge.

Referring to FIG. 3B, the storage member 220 may have a structure in which the injection nozzle 210 and the air injection pump 230 are connected on the same plane of the storage member 220.

Specifically, both the inlet and the outlet of the storage member 220 may be disposed on the same surface. In this case, the outlet of the storage member 220 may communicate with the inlet of the spray nozzle 210, and the inlet of the storage member 220 may communicate with the air injection pump 230.

In addition, in the storage member 220 as illustrated in FIG. 3B, the direction of injection of air and the direction of discharge of the sample may be opposite to each other.

Although the structures of the storage members 220 shown in FIGS. 3A and 3B are different from each other, the structures of the two storage members 220 are designed for ease of sample administration.

The air injection pump 230 may be connected to the storage member 220 to inject air into the storage member 220.

Specifically, as the air injection pump 230 injects air into the storage member 220, pneumatic pressure is generated in the storage member 220, and a stored powder-type sample may move out of the storage member 220. After the sample reaches the spray nozzle 210, it passes through the spray nozzle 210 and continuously moves, and may be eventually sprayed out of the spray nozzle 210.

By using the air injection method by the air injection pump 230 described above, the intubation and imaging apparatus 10 for inhalation experiments according to an embodiment can easily inject fine particles into the body of the test body. In addition, it is possible to inject fine particles of a certain concentration by controlling with a constant air pressure.

With reference to FIGS. 1 and 2, the photographing unit 300 is partially accommodated in the intubation 100 like the administration unit 200 and may take an image of the body of the test object.

Specifically, the photographing unit 300 may include a main body and an endoscope extending from the main body in the form of an elongated tube.

In this case, the endoscope may be a part accommodated in the intubation 100.

Such an endoscope portion may be provided to be flexibly movable according to the shape of the test body in the trachea in order to facilitate entry from the airways to the lungs according to the movement of the intubation 100. Likewise, the endoscope may be made of a soft material.

By providing the above-described photographing unit 300, the intubation and imaging device 10 for an inhalation experiment according to an embodiment can easily secure the structure and state of the airway or esophagus of the test object through an image.

Referring to FIG. 2, the guide unit 400 is accommodated in the intubation 100 and may guide the movement direction of the intubation 100.

Specifically, the guide part 400 may be a fine metal line used to guide the intubation 100 to a desired target position.

For example, nitinol may be used as a material constituting the guide part 400. In the guide part 400 made of nitinol, current may flow from the control unit, and the temperature may be changed by this process. The guide part 400 may be deformed in shape according to temperature changes. In addition, it is possible to restore the shape of the guide unit 400 as before by returning the temperature to its original state.

When the intubation 100 enters the airways and lungs by using the guide unit 400 having such a characteristic, it is possible to control the movement direction and to reach a desired position.

The above-described guide part 400 has been described using a nitinol material as an example, but the material constituting the guide part 400 is provided with an arbitrary shape memory alloy other than nitinol, or is suitable for configuring a guide wire generally used in an endoscope. It can be a material.

The control unit (not shown) may control the supply of the sample to the administration unit 200 and may control the operation of the guide unit 400.

In this case, the administration unit 200 and the guide unit 400 may be automatically controlled by detecting a signal by the control unit, and may also be manually controlled by recognizing the detected data by the user.

Specifically, the control unit may include an air injection switch 510. The user can control the administration unit 200 as desired with the air injection switch 510. That is, the timing of the sample injection and the amount of the sample to be injected may be controlled using the air injection switch 510.

In addition, the air injection switch 510 may be designed in a shape different from that shown in FIG. 1.

The air injection switch 510 may be electrically connected to the injection nozzle 210, the storage member 220, and the air injection pump 230.

When the user uses the air injection switch 510, the air injection switch 510 may transmit an electrical signal to drive the air injection pump 230.

At this time, a connection port between the storage member 220 and the air injection pump 230 may be opened. The air injection pump 230 may inject air into the storage member 220 to generate pneumatic pressure in the storage member 220.

Likewise, a connector between the storage member 220 and the spray nozzle 210 may be opened. The sample in the form of a powder stored in the storage member 220 may be moved to the spray nozzle 210 by pneumatic pressure.

At this time, the outlet of the spray nozzle 210 may be opened. The air injection pump 230 may continue to drive until a sample in the form of a powder set by the user is sprayed to the outside of the spray nozzle 210, and when the spraying is completed, the operation may be stopped.

As described above, the controller may electrically control the injection of the sample by the administration unit 200 by reflecting the user's requirements. However, in addition to the above-described control method, it is also possible for the control unit to automatically determine an appropriate injection point of the sample and control the administration unit 200 to inject the sample.

The control unit may also control the operation of the guide unit 400. This is to flexibly adjust the moving direction of the intubation 100 according to the internal structure of the test body that can be confirmed by the photographing unit 300, and ultimately, to safely reach the target position without causing bleeding or perforation in the body of the test body. to be.

Specifically, the control unit may adjust the temperature of the guide unit 400 as desired by applying a current to the guide unit 400. The guide part 400 may be deformed in shape according to temperature and may be restored to its original state. That is, the user can flexibly adjust the moving direction of the intubation 100 while changing the shape of the guide unit 400 through the control unit. In addition, as a result, the intubation 100 can be reached at a location desired by the user under the user's control.

As described above, the controller may electrically control the movement of the guide unit 400 by reflecting the user's requirements. However, in addition to the above-described control method, the control unit may automatically analyze the structure of the test body, such as airways, and control the temperature so that the guide unit 400 is flexibly deformed according to the shape.

The breathing sensor (not shown) can detect the state of inhalation or exhalation of the test object.

In addition, the breathing sensor may be electrically connected to the control unit. The breathing sensor transmits the breathing state of the test object to the control unit, and the control unit can control the administration unit 200 according to the transmitted respiration signal.

When the test body breathes, the sample can penetrate deep into the lung organ, so inhalation of the sample through the test body's self-breathing is essential. If the sample is administered directly without synchronizing the device with the breathing condition of the test subject, it may cause damage to the lung organs, which may have undesirable effects in obtaining accurate experimental results.

On the other hand, the intubation and imaging device 10 for an inhalation experiment according to an embodiment may automatically inject a sample according to the breathing state of the test object.

Referring to FIG. 4, the breathing sensor may open or close the spray nozzle 210 by transmitting an electrical signal to the control unit in a pulsed manner and turning “ON” or “OFF” of the control unit for the injection nozzle 210. have.

In FIG. 4, the time is shown as the horizontal axis for the convenience of distinguishing the opening and closing signals for the spray nozzle 210 or showing the opening/closing cycle, but this is not necessarily limited to the time in units such as seconds, minutes, and hours. , The opening time of the spray nozzle may be set and changed by the intention of the user or the control unit itself.

Specifically, when the breathing sensor detects the inhalation state of the test object, the breathing sensor may transmit the inhalation state to the control unit as an electrical signal. At this time, the control unit drives the air injection pump 230, opens the inlet and outlet of the storage member 220 to which the air injection pump 230 and the injection nozzle 210 are connected, and opens the outlet of the injection nozzle 210. have. Accordingly, a sample in the form of a powder may be sprayed to the outside of the spray nozzle 210. As a result, the breathing sensor enables the control unit to inject the sample into the lungs of the test object at the same time as the test object is inhaled. That is, the test subject can inhale the sample through self-breathing.

When the breathing sensor detects the exhalation state of the test object, the breathing sensor may transmit the exhalation state to the control unit as an electrical signal. At this time, the control unit does not drive the air injection pump 230, and closes the inlet and outlet of the storage member 220 to which the air injection pump 230 and the injection nozzle 210 are connected, and also closes the outlet of the injection nozzle 210. I can. Accordingly, the sample in the form of powder inside the storage member 220 may not be delivered to the spray nozzle 210. As a result, it is possible by the breathing sensor, the control unit to stop the driving of the administration unit 200 at the same time as the exhalation state of the test object.

As described above, in the embodiments of the present invention, specific matters such as specific components, etc., and limited embodiments and drawings have been described, but this is only provided to help a more general understanding of the present invention, and the present invention is limited to the above embodiments. It is not, and a person of ordinary skill in the field to which the present invention belongs can make various modifications and variations from this description. For example, the described techniques are performed in a different order from the described method, and/or components such as the described structure, device, etc. are combined or combined in a form different from the described method, or in other components or equivalents. Even if substituted or substituted by, appropriate results can be achieved. Therefore, the spirit of the present invention is limited to the described embodiments and should not be defined, and all things that have equivalent or equivalent modifications to the claims as well as the claims to be described later fall within the scope of the inventive concept. .

10: Intubation and imaging device for inhalation experiments
100: intubation
200: administration part
210: spray nozzle
220: storage absence
230: air injection pump
300: photographing department
400: information
510: air injection switch

Claims (7)

Intubation inserted into the test body;
An administration unit that is partially accommodated in the intubation and supplies a sample into the body of the test body;
A photographing unit that is partially accommodated in the intubation and obtains an image of the test body in the body;
A guide part accommodated in the intubation and guiding a moving direction of the intubation; And
A control unit for controlling the sample supply of the administration unit or the operation of the guide unit;
Including,
The administration unit sprays a sample in the form of a powder into the test body by pneumatic pressure,
The imaging unit can be flexibly moved into the test body according to the operation of the guide unit, intubation and imaging device for inhalation experiments.
The method of claim 1,
The guide unit,
Intubation and imaging for inhalation experiments, in which the temperature is changed by the current application of the controller, the shape is deformed or restored according to the temperature, and the movement direction of the intubation is controlled by the shape change to enter the intubation into a desired position. Device.
The method of claim 1,
Further comprising a breathing sensor for detecting the state of inhalation or exhalation of the test object,
The control unit receives a breathing signal from the breathing sensor and automatically controls the administration unit to inject a sample when the test object is inhaled. Intubation and imaging device for inhalation experiments.
The method of claim 1,
The administration unit,
A storage member for storing a sample in powder form therein;
A spray nozzle disposed inside the intubation and having one end connected to the storage member; And
An air injection pump connected to the storage member and injecting air;
Including,
An intubation and imaging device for a suction experiment in which a sample in the storage member is moved to the injection nozzle by the pneumatic pressure of the air injection pump, and the sample is injected into the body of the test object through the injection nozzle.

The method of claim 4,
The control unit,
It includes an air injection switch for controlling the drive of the air injection pump,
The air injection switch is electrically connected to the storage member, the injection nozzle, and the air injection pump,
By the air injection switch, the air injection pump is driven to generate pneumatic pressure in the storage member, the storage member is opened to transfer the stored sample to the injection nozzle, and the injection nozzle is opened to bring the sample to the outside. Intubation and imaging devices for spraying, inhalation experiments.
The method of claim 4,
The storage member,
One end of the spray nozzle is connected to one side
One end of the air injection pump is connected to the other surface, intubation and imaging device for inhalation experiments.
The method of claim 4,
The storage member,
The injection nozzle and the air injection pump are connected on the same plane of the storage member, intubation and imaging device for a suction experiment.

Images