KR101781485B1 - Drug delivery device - Google Patents

Abstract

According to the present invention, disclosed is a drug administration device capable of directly injecting a mist-formed drug through a throat part of a patient to treat a lesion or injecting a drug directly into a throat part of an animal or a lung to perform an experiment. The drug administration device of the present invention comprises: a cylinder receiving the drug; a piston moving along the inside of the cylinder; and a nozzle part coupled to the cylinder. The nozzle part includes: a drug spraying tube provided with a drug passage along a longitudinal direction, and provided with a spraying hole at a front end part; a guide member received inside the drug spraying tube; and an elastic member coupled in a spiral direction along an outer circumferential surface of the guide member.

Description

Drug delivery here {Drug delivery device}

The present invention relates to a drug dispenser capable of directly spraying a mist-shaped drug through a patient's throat to treat a lesion, or to conduct experiments by injecting a drug directly into the throat or lung of an animal.

In general, drug delivery can be used to treat lesions by injecting the drug into the lesion in a liquid state.

Such drug delivery is disclosed in Korean Patent Registration No. 10-0589077. The above-mentioned publication discloses a mechanical structure for injecting a therapeutic drug into the skin.

However, in order to increase the therapeutic effect of a patient or to perform an animal test to obtain reliable experimental data, it is necessary to directly spray a mist type drug at a position adjacent to the throat or lung of a patient or an animal, There is a problem that can not be done.

In addition, conventional techniques can inject drugs only in liquid form or in a patient or animal through self-breathing using a separate mist generator. However, in order to maximize the therapeutic effect of the patient, it is necessary for the medical staff to directly inject the mist type drug into the lesion of the patient through the throat, but it can not sufficiently cope with this. In addition, in order to obtain reliable experimental results in an animal experiment, the experimenter must inject the drug directly into the throat or lung of the animal in the form of mist, but existing devices are difficult to perform such experiments.

Korean Patent Registration No. 10-0589077 (registered on June 5, 2006)

SUMMARY OF THE INVENTION Accordingly, the present invention has been made in order to solve the above-mentioned problems, and it is an object of the present invention to provide a medical treatment method and a method for treating a lesion of a patient by injecting a drug directly into a lesion through a throat of a patient, To a drug delivery system.

Another object of the present invention is to provide a drug administration device which injects into the throat or lungs of a laboratory animal to perform various animal experiments and increases the precision of the experimental results.

It is still another object of the present invention to provide a drug administration device capable of injecting a drug into a drip state or a mist state with a single nozzle so that the drug can be used in a versatile manner.

In order to accomplish the object of the present invention as described above, the present invention includes a cylinder accommodating a drug, a piston moving along the inside of the cylinder, and a nozzle unit coupled to the cylinder, There is provided a drug administration device comprising a drug delivery tube provided with a transfer passage and provided with a spray hole at a distal end thereof, a guide member received in the drug delivery tube, and an elastic member coupled in a spiral direction along an outer circumferential surface of the guide member have.

And the elastic member is preferably disposed so as to protrude partially toward the distal end side of the guide member.

Wherein the elastic member is made of a compression coil spring, and a rotation part for drug rotation is provided between the pitches of the compression coil spring, and the rotation part for drug rotation is moved in accordance with the pressure of the drug supplied to the drug movement passage of the drug injection tube Its interval can be varied.

It is preferable that the guide member and the elastic member have at least one or more fixing portions.

It is preferable that the drug dispensing tube has a surface portion having a front end viewed from the side, and a corner portion of the surface portion is formed of a round portion.

And the injection hole of the drug injection tube may be a tapered part whose diameter is increased toward the distal end side of the drug injection tube.

It is preferable that an inner nozzle is disposed inside the drug spray tube and a plurality of inner spray holes are provided in the inner nozzle.

It is preferable that the internal injection holes are formed in plural and penetrate in the oblique direction with respect to the side or tip of the internal nozzle.

The inner injection holes are preferably staggered from each other on a line from the front.

The drug supply part may include a cylinder in which the drug is received and a piston moving along the inside of the cylinder.

The drug supply unit may include a chemical liquid tank which receives the drug at a predetermined pressure and is connected to the nozzle unit through a conduit, an injection pressure control valve installed in the conduit, and an injection pressure regulating valve To control the pressure or the injection amount of the drug.

The present invention can be manufactured through a simple structure, and a medicament in a drip or mist state can be directly sprayed on a lesion of a patient's throat or the like, thereby maximizing the therapeutic effect.

The present invention is capable of selectively injecting drops or mist, but the diameter of the nozzle is very small, which can minimize the inconvenience of the patient when injecting the drug into the patient.

The present invention is also capable of spraying a mist-like drug relatively uniformly in an animal experiment, thereby improving the precision of animal experiments.

In addition, the present invention has an effect that the drug can be injected into a patient or an animal in a state of being dripped or misted through a single device, thereby enhancing versatility.

In addition, the present invention has an effect that the spray particles can be adjusted to the experimental conditions by adjusting the pitch of the elastic member according to the pressure of the supplied drug.

In addition, the present invention has an effect that a uniform amount of drug can be injected, so that a large number of animal experiments can be easily performed repeatedly.

BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is an outline view showing a drug doser for explaining a first embodiment of the present invention. FIG.
2 is a sectional view of the nozzle unit taken along line II-II in FIG.
FIG. 3 is a view showing the nozzle unit to explain the action when a relatively high pressure drug is supplied to the nozzle unit. FIG.
4 is a cross-sectional view of the nozzle unit taken along the longitudinal direction for explaining the second embodiment of the present invention.
FIG. 5 is a cross-sectional view of the nozzle section taken along the longitudinal direction for explaining a third embodiment of the present invention.
FIG. 6 is a view for explaining the spraying process of the drug of FIG. 5;
7 is a configuration diagram for explaining another example of the first embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In order to clearly illustrate the present invention, parts not related to the description are omitted, and the same or similar components are denoted by the same reference numerals throughout the specification.

An embodiment of the present invention may be applied to an apparatus for photographing a throat of a patient or a back of a laboratory animal using a video camera and displaying the image on a display. However, in an embodiment of the present invention, do.

Fig. 1 is a perspective view for explaining a first embodiment of the present invention, showing a drug dosing machine.

The drug delivery system of the first embodiment of the present invention includes a cylinder 1, a piston 3, and a nozzle unit 5.

The cylinder 1 is provided with a space therein so that the drug can be accommodated. The piston 3 moves along the inner space of the cylinder 1 and can spray the drug out of the cylinder 1 through the nozzle portion 5 in a state of being in a state of being in a state of being in a state of being misty or misty.

The nozzle portion 5 is coupled to the cylinder 1 and may include a drug spray tube 7, a guide member 9 and an elastic member 11 as shown in Fig.

The drug delivery tube 7 is made of a hollow body and is provided with a drug transfer passage 7a, and can be formed into an elongated pipe shape. It is preferable that the drug delivery tube 7 is provided with a spray hole 7b in the middle portion of the distal end portion.

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The drug delivery tube 7 is provided with a surface portion 7c having a front end surface and a spray hole 7b is provided through the central portion of the surface portion 7c. The corner portion of the surface portion 7c includes a round portion 7d formed in a round shape. The round portion 7d can serve to facilitate insertion of the test rat without damaging the throat of the test rat.

It is preferable that the spray hole 7b of the drug spray tube 7 is formed by the tapered portion 7e at the portion facing outward of the surface portion 7c. In other words, it is preferable that the tapered portion 7e is a part of the injection hole 7b and the diameter becomes larger toward the surface 7c side. This tapered portion 7e is intended to allow the spray particles to spread out when spraying the drug in the mist state.

The guide member 9 can be received in the inside of the drug delivery tube 7. The guide member 9 preferably has a cylindrical shape. This guide member 9 can be moved in some sections along the drug passage 7a of the drug delivery tube 7.

The elastic member 11 can be coupled in the spiral direction along the outer circumferential surface of the guide member 9. The elastic member 11 may be formed of a compression coil spring, and the compression coil spring preferably has a circular cross section. It is preferable that the elastic member 11 is partially protruded toward the distal end side of the guide member 9. That is, the elastic member 11 is longer than the guide member 9, and a part of the elastic member 11 is preferably longer than the guide member 9 in the injection hole 7b.

The elastic member 11 has a fixed portion 11a which is joined to a part of the guide member 9 by welding or the like. The fixing portion 11a may be formed of one or more members. It is preferable that a part of the outer circumferential side of the guide member 9 and a part of the elastic member 11 are welded to each other by the fixing part 11a to which the elastic member 11 and the guide member 9 are coupled ).

The guide member 9 and the elastic member 11 may not be deformed in the elastic member 11 when the pressure of the drug supplied through the drug moving passage 7a is low. The elastic member 11 can be compressed while the guide member 9 and the elastic member 11 move toward the injection hole 7b.

The space provided between the pitches of the elastic members 11 is a passage through which the drug passes, and the drug rotation transfer portion 11b through which the drug rotates in the spiral direction.

The drug rotary motion portion 11b can be varied in its interval (indicated by p1 in Fig. 2 and p2 in Fig. 3) depending on the pressure of the drug supplied to the drug passage 7a of the drug delivery tube 7 . That is, when the pressure of the drug supplied to the drug passage 7a is low, the pitch of the elastic member 11 is kept large. When the pressure of the drug is high, the elastic member 11 is compressed, State can be maintained. Therefore, the drug rotation transfer portion 11b can be varied in its interval according to the pressure of the drug supplied to the drug transfer passage 7a.

In other words, the interval of the drug rotation transfer part 11b is changed according to the supplied pressure of the drug, and the drug solution can be ejected in a drip state or a mist state, and the spray particles can be controlled.

In the first embodiment of the present invention, the medicament of the present invention can be used to directly or indirectly administer medicines in the form of drops or mist to the lesions of the patient's throat or the like, or inject medicines into the lungs through the airways of the animals Here is an example of how to do this.

First, the process of supplying the drug in a drip state to the throat of the patient or the throat of the experimental mouse is described. The experimenter inserts the drug into the cylinder (1) and presses the piston (3) at a relatively low pressure. Then, the piston 3 moves along the cylinder 1 and pushes the medicine contained in the inside of the cylinder 1 toward the nozzle part 5 side. At this time, it is preferable that the pressure applied by the medical staff or the experimenter to the piston 3 is such that the elastic force of the elastic member 11 is not affected.

Then, the drug moves along the drug transfer path 7a of the drug delivery tube 7 and through the drug rotation transfer part 11b provided between the pitches of the elastic member 11.

At this time, since the drug is supplied at a pressure smaller than the elastic force of the elastic member 11, the elastic member 11 remains unmodified (the state shown in Fig. 2). The drug supplied through the drug rotation transfer portion 11b is discharged to the outside of the drug delivery tube 7 through the injection hole 7b.

In this case, the drug may be supplied to the throat of the patient or the throat of the experimental mouse in a state of drip.

Next, a description will be given of a process in which the drug can be supplied in the mist state to the throat of the patient or the throat of the experimental rat.

The medical staff or the experimenter presses the pressure of the piston 3 higher when it is necessary to spray the medicine through the spray hole 7b of the drug spray tube 7 in the mist state. In this case, it is preferable to apply pressure to the piston 3 to such an extent that the elastic member 11 can be deformed.

Then, the drug presses and moves the guide member 9 while moving along the drug-moving path 7a of the drug-injecting tube 7. As the guide member 9 moves, the elastic member 11 is compressed and the pitch of the elastic member 11 is narrowed, and the interval of the drug rotation transfer portion 11b is narrowed. At this time, the drug is sprayed through the spray hole 7b through the narrowed gap of the drug rotation transfer part 11b with a relatively high pressure in the spiral direction, and the drug is sprayed in the mist state (see FIG. 3).

The drug injected in the mist state can be uniformly sprayed to the lungs of the patient's throat or the experimental rat. Therefore, it is possible to maximize the therapeutic effect of the patient's lesion, or to increase the accuracy of the inhalation toxicity test using a laboratory mouse or the like.

In this way, the drug can be injected in a drip or mist state depending on the condition of the patient or the inhalation toxicity test conditions. The present invention can be used according to the condition of a patient or an experimental condition of an animal by spraying the drug in a drip state or a mist state using one apparatus.

Fig. 4 is a view for explaining a second embodiment of the present invention, showing a nozzle unit 5 for drug delivery. In the description of the nozzle unit 5 of the second embodiment of the present invention, the same parts as those of the first embodiment described above are denoted by the same reference numerals, and only the other parts will be described.

In the nozzle unit 5 of the second embodiment of the present invention, the guide member 9 and the elastic member 11 are arranged at the same size and fixed via at least two fixing portions 11a. That is, in the nozzle unit 5 of the second embodiment, the elastic member 11 is disposed on the outer circumferential surface of the guide member 9, and both sides of the guide member 9 are fixed by the fixing portion 11a, The elastic member 11 is integrally coupled. At this time, the elastic member 11 is compressed to minimize the pitch thereof, so that the distance between the drug-rotating portions 11b is narrowed so that the drug in the mist state can always be discharged. The second embodiment of the present invention can spray the drug in a mist state, which is always very small spray particles. That is, even when the medical staff or the experimenter applies the pressure of the piston 3 at any pressure, the drug is always narrowed in the spiral interval of the drug rotation transfer portion 11b and the medicine is sprayed through the injection hole 7b while moving along the spiral at high pressure It can be sprayed in the mist state of the fine particles.

The second embodiment of the present invention can be used in an inhalation toxicity test of a mouse for treating a lesion of a patient by spraying a drug exclusively for mist, and it is possible to increase the therapeutic effect of the patient or improve the accuracy of the test result.

FIGS. 5 and 6 are views for explaining a third embodiment of the present invention, showing a nozzle unit 5 for drug delivery. In the description of the nozzle unit 5 of the third embodiment of the present invention, the same parts as those of the above-described first embodiment are denoted by the same reference numerals, and only the other parts will be described.

The nozzle unit 5 of the third embodiment of the present invention includes a drug delivery tube 7 and an inner nozzle 13 disposed therein.

The inner nozzle 13 may move along the longitudinal direction of the drug delivery tube 7 and may rotate.

It is preferable that the inner nozzle 13 has a hollow shape and a portion facing the spray hole 7b is closed. The inner nozzle 13 is provided with a plurality of inner spray holes 13a and 13b at the spray hole 7b side. The inner spray holes 13a and 13b may be provided on the side surface of the inner nozzle 13, that is, in the radial direction, or may be provided in an inclined direction with respect to the tip portion (the direction toward the spray hole 7b).

Further, the internal injection holes 13a and 13b may be staggered from each other on the line when viewed from the front (see FIG. 6).

In the third embodiment of the present invention, the drug supplied to the drug passage 7a of the drug delivery tube 7 flows into the interior of the inner nozzle 13 and then exits to the inner injection holes 13a and 13b . At this time, the drug passing through the inner spray holes 13a and 13b acts at a high pressure and the inner spray holes 13a and 13b are staggered from each other so that the spray holes 7b of the drug spray pipe 7 ≪ / RTI > In this process, the inner nozzle 13 is also rotated to eject the drug into the inner injection holes 13a and 13b (the direction in which the drug is injected is indicated by an arrow in FIG. 6). The drug sprayed through the inner spray holes 13a and 13b can be ejected in a mist state while exiting the spray hole 7b of the drug spray tube 7. [

Therefore, in the third embodiment of the present invention, the drug can be sprayed in a mist state through a simple structure, so that the drug is injected directly into the lesion through the throat of the patient to enhance the therapeutic effect of the lesion, The drug can be uniformly injected into the lungs through the throat of the animal, thereby increasing the precision of the experiment.

Fig. 7 is a diagram for explaining another example of the first embodiment of the present invention, and only differences from the first embodiment will be described.

Although the first embodiment of the present invention has described an example in which an experimenter presses a drug contained in a cylinder with a piston to regulate the pressure of the drug, another example of the first embodiment of the present invention is that the medical staff or the experimenter inputs various pressure values Alternatively, the medical staff or the experimenter may adjust the pressure of the medicine supplied to the nozzle unit 5 while changing the pressure value, if necessary.

That is, the drug supply unit 15 for supplying the drug to the nozzle unit 5 includes a chemical liquid tank T, an input unit IN, a pressure regulating switch S, a control unit C, and an injection pressure regulating valve V . The control unit C may be connected to the output unit OUT and the data storage unit ST.

The chemical tank (T) can be made of a pressure tank, and the liquid drug can be received at an appropriate pressure. The chemical liquid tank T may be connected to the nozzle unit 5 by a channel so as to supply the drug to the nozzle unit 5. And a spray pressure regulating valve V may be installed in a line connecting the chemical liquid tank T and the nozzle unit 5. [ The injection pressure regulating valve V can pass the pressure of the drug injected to the nozzle unit 5 under the control of the control unit C with a weak or high pressure.

The input unit IN is connected to the control unit C and can set the pressure of the drug or the injection amount of the drug desired by the medical staff or the experimenter. The control unit C can control the injection pressure control valve V based on the data input through the input unit IN. The pressure regulating switch S is also connected to the control unit C so that the medical personnel can operate the target of direct treatment of the lesion of the patient or the experimenter according to the experimental condition of the animal to transmit the reference signal of the pressure of the drug or the injection quantity of the drug to the control unit C Lt; / RTI > The controller C may control the pressure of the drug supplied to the nozzle unit 5 or the injection amount of the drug by adjusting the injection pressure control valve V according to the input value of the pressure control switch S. [ The control unit C outputs the value inputted by the input unit IN or the pressure regulating switch S and the pressure and amount of the drug injected to the nozzle unit 5 through the actual injection pressure regulating valve V (OUT), and can be stored in the data storage unit (ST).

Another example of this first embodiment of the present invention is that in the case of an animal experiment, the control unit C adjusts and injects the drug according to the data input by the input unit IN or the pressure control switch S and outputs the result By recording, it can be used suitably for many repetitive experiments.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments, but, on the contrary, And it goes without saying that the invention belongs to the scope of the invention.

1. Cylinder, 3. Piston,
5. The nozzle part,
7. Drug Dispenser, 7a. A drug passage,
7b. Injection, 7c. Face,
7d. Round section, 7e. Tapered portion,
9. Guide member,
11. Elastic member, 11a. However,
11b. In addition,
13. Inner nozzle, 13a, 13b. Inner spray hole
15. Drug Supply Unit

Claims (10)

The drug delivery unit
And a nozzle unit coupled to the drug supply unit to inject the drug,
The nozzle portion
A drug delivery tube provided with a drug passage along its longitudinal direction and provided with a spray hole at its tip,
A guide member accommodated in the drug delivery tube, and
And an elastic member coupled in a spiral direction along an outer circumferential surface of the guide member,
The elastic member
Wherein the compression coil spring is composed of a compression coil spring, a drug rotation moving part is provided between the pitches of the compression coil spring,
The drug-
Wherein the interval of the drug delivery tube is variable according to the pressure of the drug supplied to the drug delivery channel of the drug delivery tube. The method according to claim 1,
The elastic member
And a part of the guide member protrudes from the distal end side of the guide member. delete The method according to claim 1,
The guide member and the elastic member
A drug delivery system comprising at least one retaining member. The method according to claim 1,
The drug delivery tube
Wherein a front end portion is composed of a surface portion that is seen from the side surface, and a corner portion of the surface portion is composed of a round portion. The method according to claim 1,
The injection hole of the drug delivery tube
And a tapered portion whose diameter is increased toward the distal end side of the drug delivery tube. delete delete The method according to claim 1,
The drug supply part
The cylinder containing the drug
A piston moving along the inside of the cylinder
Drug-containing drug here. The method according to claim 1,
The drug supply part
A chemical liquid tank which receives the drug at a constant pressure and is connected to the nozzle unit by a conduit,
An injection pressure regulating valve installed in the pipeline, and
A control unit for controlling the injection pressure control valve according to a value input by the input unit or the pressure control switch to control the pressure or injection amount of the drug,
Drug-containing drug here.

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