KR20200061231A - A preservative comprising methylchavicol for skin external application, and a cosmetic composition and a pharmaceutical composition comprising the same - Google Patents

Abstract

Provided are a preservative for external preparation for skin containing methyl chavicol, and a cosmetic composition and pharmaceutical composition containing the same. According to one aspect of the preservative for external preparation for skin, since effective antimicrobial effects are derived even in aqueous formulations, the application to aqueous formulations is not limited, the alkanediol-based components that may cause problems such as skin irritation are minimized, and remarkably excellent antiseptic power compared to conventional paraben-based preservatives can be secured.

Description

A preservative comprising methylchavicol for skin external application, and a cosmetic composition and a pharmaceutical composition comprising the same}

Preservatives for external preparations for skin, and cosmetic compositions and pharmaceutical compositions comprising the same.

Since the cosmetic composition and the pharmaceutical composition for external application for skin cannot avoid contamination by microorganisms during the manufacturing process and use, a preservative is used for the purpose of improving the preservation power of the product. Widely used as such preservatives are preservatives such as parabens preservatives (sodium paraoxybenzoate), imidazolidinylurea, and phenoxyethanol. These preservatives have high antimicrobial properties and are very good in preservation, but are often known to cause toxicity, skin irritation, and allergies. Accordingly, preservatives for external preparations for skin having a high preservation power without inducing skin irritation have been developed, and there is a need to develop safe preservatives for external preparations for skin that have superior preservation power.

As part of these studies, preservative studies for external preparations for skin using diols with known antibacterial activity have been conducted. Republic of Korea Patent Publication 2013-0049729 is a ternary antibacterial composition acting synergistically 2-phenoxyethanol; And at least two different alkanediols selected from the group consisting of 1,2-decanediol, 1,2-octanediol, 1,2-hexanediol, and 1,2-pentanediol. However, it is known that a large amount of the alkanediol component in the ternary mixture has disadvantages such as toxicity, skin irritation, or allergies.

On the other hand, methyl chabicol is a substance that is separated or extracted from basil, guwak, and the like. In some prior literature, methyl chabicol is disclosed as one active ingredient of the cosmetic composition, but methyl chabicol contained in the cosmetic composition is only mentioned as one of the fragrance components, and mentions any matters regarding their antibacterial activity. Not doing

Under these backgrounds, the present inventors have made great efforts to develop preservatives for external preparations for skin with excellent stability, and as a result, prepare preservatives for external preparations for skin having excellent antibacterial or antiseptic properties through a combination of low concentrations of butylene glycol and methyl chabicol. By confirming that it is possible, the present application was completed.

One aspect is the methyl chabicol of the formula (1), or cosmetic or pharmaceutically acceptable salts thereof

[Formula 1]

; 및

; And

It provides a preservative for external preparations for skin, which contains butylene glycol, and contains 2 to 9% by weight of the butylene glycol based on the total weight of the preservative for external preparations for skin.

Another aspect is to provide a cosmetic composition comprising a preservative for the external preparation for skin.

Another aspect is to provide a pharmaceutical composition for external application for skin comprising a preservative for external application for skin.

Another aspect is to provide a method for preparing a skin external preparation that precludes using the preservative for a skin external preparation as a preservative.

Hereinafter, the present invention will be described in more detail.

All technical terms used in the present invention, unless defined otherwise, are used in a sense as commonly understood by those skilled in the art in the relevant field of the present invention. In addition, although a preferred method or sample is described herein, similar or equivalent ones are included in the scope of the present invention. The contents of all publications described by reference herein are incorporated herein by reference in their entirety.

As used herein, the term “skin external preparation” is a concept encompassing the overall composition applied to the skin, and includes, for example, various cosmetics such as basic cosmetics, makeup cosmetics, and hair cosmetics; It is a concept that includes pharmaceutical compositions, such as ointments, creams, and lotions, and pharmaceutical compositions that are applied externally to the skin, including quasi drugs.

As used herein, the term “antibacterial” refers to resistance to all contaminating microorganisms such as bacteria, fungi, and yeast, and “antibacterial” refers to defense against these contaminating microorganisms, and “preservative” microorganisms It means the defense against corruption by contamination by and is a concept including antibacterial activity.

As used herein, the term "preservative" refers to a substance that has a preservative or antioxidant ability to prevent deterioration of a product for a long period of time and to maintain its original state, and "preservation power" prevents deterioration of a product for a long period of time and prevents the original condition of the product. It means the defense that can be kept.

The present inventors, as a result of diligent efforts to derive an active ingredient of a preservative for skin external preparations that can secure remarkably superior antibacterial and preservative power compared to a conventional preservative, methyl chabicol was derived as the active ingredient. Despite its own antibacterial activity, formulations such as cosmetics, in particular, aqueous formulations did not show its antibacterial activity, and thus attempted to solve this problem.

As a result, the combination of methyl chabicol and polysorbate 40, the combination of methyl chabicol and polysorbate 80, still had antimicrobial activity disappeared or markedly decreased in aqueous formulations, while methyl chabicol and low concentrations of butylene glycol Combination of was confirmed that significant antibacterial activity is maintained even in the aqueous formulation (see Test Example 1). In addition, these effects were not due to the synergistic effect of the antibacterial activity of butylene glycol itself, and the dispersion of methyl chabicol as a mixed solvent, but also from the interaction between methyl chabicol and each component (test Examples 2 and 3), the combination of the methyl chabicol and the low concentration of butylene glycol, while minimizing the content of the alkanediol-based component that may cause problems such as skin irritation, compared to conventional parabens preservatives It was confirmed that excellent antiseptic power was exhibited (see Test Example 4).

Accordingly, one aspect of the present invention is methyl chabicol of formula 1, or a cosmetic or pharmaceutically acceptable salt thereof

[Formula 1]

; 및

; And

It provides a preservative for external preparations for skin, which includes butylene glycol and contains 2 to 9% by weight of the butylene glycol based on the total weight of the preservative for external preparations for skin.

The methyl chabicol may include a methyl chabicol derivative having antibacterial, preservative, and/or antiseptic properties similar to methyl chabicol.

The methyl chabicol can be obtained by a method known to those of ordinary skill in the art. In one embodiment, the methyl chabicol may be contained in basil oil or gwakyang.

In one embodiment, the preservative for the external preparation for skin may include 0.1 to 2% by weight of methyl chabicol, and 2 to 9% by weight of butylene glycol, based on the total weight of the preservative for external use for skin. For example, the content of methyl chabicol contained in the preservative for external preparations for skin is 0.1 to 1.5% by weight, 0.1 to 1.0% by weight, 0.1 to 0.5% by weight, 0.2 to 2% by weight, 0.2 to 1.5% by weight, 0.2 to 1.0 It may be weight%, 0.2 to 0.5% by weight, 0.5 to 2% by weight, 0.5 to 1.5% by weight, 0.5 to 1.0% by weight, 1.0 to 2.0% by weight, or 1.0 to 1.5% by weight, and the content of butylene glycol is 2 To 7 wt%, 2 to 5 wt%, 2 to 3 wt%, 3 to 9 wt%, 3 to 7 wt%, 3 to 5 wt%, 4 to 9 wt%, 4 to 7 wt%, 4 to 5 Weight percent, 5 to 9 weight percent, or 5 to 7 weight percent.

The preservative for external preparations for skin may include methyl chabicol and butylene glycol in a weight ratio of 1.0:10.0 to 1:50.0. When the weight ratio of the methyl chabicol and the butylene glycol is 1.0:10.0 or less, or the content of the methyl chabicol is high, formulation may be difficult, and the weight ratio of the methyl chabicol and the butylene glycol may be a weight ratio of 1:50.0. If it is abnormal or the content of butylene glycol is high, skin irritation or the like may be caused by an alkanediol-based component, or a decrease in antimicrobial activity due to reduction of an active component may be caused.

Another aspect of the present invention provides a cosmetic composition comprising a preservative for the external preparation for skin.

The cosmetic composition may be provided as a cosmetic composition having high storage power and safety by including a preservative for the external preparation for skin. The content of the preservative for external application for skin used in the cosmetic composition is not particularly limited as long as it can secure a desired preservation power, and can be appropriately determined by a person skilled in the art according to the degree of preservation power desired. In one embodiment, the preservative for the external preparation for skin may be included in an amount of 0.01 to 10% by weight, 0.1 to 10% by weight, 0.1 to 5% by weight, or 0.1 to 2% by weight relative to the total weight of the cosmetic composition.

The cosmetic composition may be any formulation known as a cosmetic composition, for example, skin, emulsion, cream, sun cream, foundation, essence, gel, pack, mask pack, foam cleanser, body cleanser, soft cosmetic, eye Liner, shampoo, rinse, soap, hair dressing, wool, hair cream, hair styling gel, lubricant, toothpaste and wipes may be one selected from the group consisting of, but not limited to.

Another aspect of the present invention provides a pharmaceutical composition for external application for skin comprising a preservative for external application for skin.

The pharmaceutical composition for external application for skin may be provided as a pharmaceutical composition applicable as an external application to skin having high preservation power and safety by including a preservative for external application for skin. The content of the preservative for the external preparation for skin used in the pharmaceutical composition for external application for skin is not particularly limited as long as the desired preservation power can be secured, and can be appropriately determined by those skilled in the art according to the desired degree of preservation power. For example, the preservative for external application for skin may be included in an amount of 0.01 to 10% by weight, 0.1 to 10% by weight, 0.1 to 5% by weight, or 0.1 to 2% by weight relative to the total weight of the pharmaceutical composition for external application for skin.

The pharmaceutical composition for external application for skin may be any formulation known as an external preparation for skin, for example, warning agents, linen agents, ointments, pasta agents, cataplasma agents, suspension agents, emulsions, lotion agents, aerosol agents, And it may be a formulation that is one selected from the group consisting of suppositories, but is not limited thereto.

The pharmaceutical composition for external application for skin may be for systemic action of the active ingredient by skin application or may be for local action of the active ingredient by skin application. In one embodiment, the pharmaceutical composition is for topical action of the active ingredient by skin application.

The cosmetic composition and the pharmaceutical composition for external application for skin may further include various known additives in a range that does not impair the effect of the preservative for external preparation for skin according to the formulation, in addition to the preservative for external preparation for skin. According to the carrier, an emulsifier, a moisturizer, a skin conditioning agent, a surfactant, a chelating agent, an antioxidant, a bactericide, a stabilizer, and any combinations thereof, may further include additives selected from the group consisting of.

The carrier includes animal fiber, plant fiber, wax, paraffin, starch, tragacanth, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide, lactose, silica, aluminum hydroxide, calcium silicate, poly Amide powder, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, glycerol aliphatic ester, polyethylene glycol, liquid diluent, ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxy Suspension agents such as ethylene sorbitan ester, microcrystalline cellulose, aluminum metahydroxide, bentonite, agar or tragacanth, aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivatives , Methyl taurate, sarcosinate, fatty acid amide ether sulfate, alkylamidobetaine, aliphatic alcohol, fatty acid glyceride, fatty acid diethanolamide, vegetable oil, linoline derivative, or ethoxylated glycerol fatty acid ester and the like. However, it is not limited thereto.

Examples of the emulsifier include liquid paraffin, cetyl octanoate, and stearic acid, but are not limited thereto.

The moisturizing agent includes glycerin, glyceryl stearate, and the like, but is not limited thereto.

Examples of the skin conditioning agent include sariclomethicone and dimethicone, but are not limited thereto.

Examples of the surfactant include cetostearyl alcohol, triethanolamine, and carboxyvinyl polymer, but are not limited thereto.

The chelating agent includes ethylenediaminetetraacetic acid sodium (EDTA), α-hydroxy fatty acid, lactoferrin, α-hydroxy acid, citric acid, lactic acid, malic acid, bilirubin, biliverdin, etc., but is not limited thereto. no.

Examples of the antioxidant include butylhydroxyanisole, dibutylhydroxytoluene or propyl gallate, but are not limited thereto.

In addition, there are oil and fat ingredients, emollients, organic and inorganic pigments, organic powders, ultraviolet absorbers, pH adjusting agents, alcohols, pigments, fragrances, blood circulation accelerators, coolants, limiting agents, etc. .

Another aspect of the present invention provides a method for preparing an external preparation for skin, comprising using the preservative for external preparations for skin as a preservative.

The details of the method for manufacturing the external preparation for skin may be applied to the preservative for external preparation for skin, cosmetic composition, and pharmaceutical composition for external preparation for skin according to one aspect of the present invention.

In one embodiment, the external preparation for skin may be a cosmetic composition or a pharmaceutical composition for external application for skin.

The preservative for external preparations for skin may be used in an amount of 0.01 to 10% by weight relative to the cosmetic composition or pharmaceutical composition for external preparations for skin.

Preservatives for external preparations for skin according to one aspect may exhibit an effective antimicrobial effect in an aqueous formulation, and application to an aqueous formulation is not limited.

In addition, the preservative for external preparations for skin according to an aspect may exhibit excellent antiseptic power compared to a conventional paraben-based preservative while minimizing the content of an alkanediol-based component that may cause problems such as skin irritation.

Therefore, the preservatives for external preparations for skin can be used to produce not only high preservation power and safety, but also cosmetic compositions and pharmaceutical compositions that are aqueous preparations.

Hereinafter, the present invention will be described in more detail through examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.

Test Example 1. Antibacterial activity test for combination of methyl chabicol and additional ingredients

In this test example, the antibacterial activity of the combination of methyl chabicol and additional components was evaluated. E. coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), Staphylococcus aureus (ATCC 6538), Anise pergillus niger (ATCC 16404) and Candida albi, using a combination of methyl chabicol and additional ingredients The antibacterial activity of Cans (ATCC 10231) against bacteria, yeast, and fungi was measured.

Specifically, the content of methyl chabicol is adjusted to a level of 0.1 to 0.5% (w/w), and 2 to 10% (w/w) of butylene glycol, polysorbate 40, and polysorbate 80 are added thereto. Alternatively, each sample was prepared by mixing. Subsequently, each of the bacteria and yeasts was inoculated at a concentration of 10 ⁶ /ml and fungi at 10 ⁴ /ml in 10 ml of the liquid culture prepared by adding the sample to tryptic soy medium (TSB). After culturing the liquid culture solution inoculated with the bacteria and yeasts at 32° C. for 24 hours, their antibacterial effects were evaluated.

(1) Methyl chabicol and butylene glycol

The antibacterial activity by the combination of methyl chabicol and butylene glycol was evaluated according to the components and contents shown in Table 1 below.

Table 2 is a result of evaluating the antibacterial activity by the combination of methyl chabicol and butylene glycol. As shown in Table 2 below, treatment with butylene glycol alone did not show any antibacterial activity (Example 1), and treatment with a combination of methyl chabicol and butylene glycol gave 5% (w/w) butylene glycol. As a guide, significant antibacterial activity was exhibited from the case where the methyl chabicol content was 0.3% (w/w) or more (Examples 4 to 6).

(2) Methyl chabicol and polysorbate 40

According to the components and contents listed in Table 3, antibacterial activity was evaluated by the combination of methyl chabicol and polysorbate 40.

Table 4 is a result of evaluating the antibacterial activity by the combination of methyl chabicol and polysorbate 40. As shown in Table 4 below, the combination of methylchabicol and polysorbate 40 did not show antibacterial activity at all content conditions.

(3) methylchabicol and polysorbate 80

The antibacterial activity by the combination of methyl chabicol and polysorbate 80 was evaluated according to the ingredients and contents shown in Table 5 below.

Table 6 is a result of evaluating the antibacterial activity by the combination of methyl chabicol and polysorbate 80. As shown in Table 4 below, the combination of methylchabicol and polysorbate 80 did not show antibacterial activity at all content conditions.

When the results of the above experiments were put together, the antibacterial activity showed a significant difference depending on the type of the additional component mixed with methyl chabicol, and in particular, it was significant when the combination of butylene glycol and methyl chabicol was used as an additional component. It was found that the antibacterial activity was exerted.

Test Example 2. Antibacterial activity test for additional ingredients

In this test example, the antimicrobial activity of the additional components used in Test Example 1 was evaluated. As in Test Example 1, E. coli (ATCC 8739), Pseudomonas aeruginosa (ATCC 9027), Staphylococcus aureus (ATCC 6538), Anise pergillus niger (ATCC 16404) and Candida albicans (ATCC 10231) The antibacterial activity of bacteria, yeast and fungi was evaluated. Specifically, while adjusting the content of butylene glycol or polysorbate 40, the minimum concentration showing antibacterial activity was measured.

Table 7 shows the results confirming the minimum concentrations of butylene glycol, polysorbate 40, and polysorbate 80 showing antibacterial activity. As shown in Table 7 below, butylene glycol, polysorbate 40, and polysorbate 80 all did not exhibit antibacterial activity at a concentration of 10% (w/w) or less.

Considering that the concentrations of butylene glycol in Test Example 1 were all used at 10% (w/w) or less, the antibacterial activity by the combination of methyl chabicol and butylene glycol identified in Test Example 1 was butyl. It was found that it was not derived from the antibacterial activity or synergistic action of ren glycol alone.

Test Example 3. Evaluation of dispersibility of methyl chabicol by adding additional components

In this test example, the influence of the additional components of Test Example 1 on the dispersing power of methyl chabicol was confirmed. A composition for external application for skin containing butylene glycol or polysorbate 80 was prepared according to the components and contents shown in Table 8 below, and the degree of dispersion thereof was confirmed. The dispersion degree was evaluated according to whether the two materials are evenly mixed and are transparent to the naked eye.

As shown in Table 8 below, the dispersion degree by the combination of methyl chabicol and butylene glycol was not significantly different from the combination of methyl chabicol and polysorbate 80. Rather, in terms of the transparency of the mixture, it was evaluated that the effect of the combination of methyl chabicol and polysorbate 80 was better.

When combined with the experimental results of Test Examples 1 to 3, the combination of methyl chabicol and butylene glycol, the combination of methyl chabicol and polysorbate 40, or polysorbate 80 can all be formulated into an aqueous formulation. However, there was a marked difference in their antibacterial activity. This significant difference was not due to the antibacterial activity of each additional component itself or the degree of dispersion of methyl chabicol, but was expected as a result of the interaction between methyl chabicol and each component. That is, according to this interaction, the combination of methylchabicol and polysorbate 40 or polysorbate 80 destroys the antimicrobial activity of methylchabicol in aqueous formulations, while the combination of methylchabicol and butylene glycol is methyl. It was found that the antibacterial activity of Chabicol was maintained or increased.

Test Example 4. Preparation of cosmetic composition and antiseptic power test

In this test example, a preservative power in the cosmetic composition of the emulsion formulation was evaluated using a combination of methyl chabicol and an additional component. First, using a combination of methyl chabicol and an additional component, a cosmetic composition of each emulsion formulation was prepared. In Comparative Example 1, no chemical preservative was used in the preparation, and in Comparative Example 2, an emulsion formulation was prepared in the same manner, except that a combination of ethyl paraben and phenoxyethanol was used as the chemical preservative.

Subsequently, an initial concentration of 10 ⁶ cfu (colonization) of each bacterial solution of E. coli (ATCC 8739), Staphylococcus aureus (ATCC 6538), and Pseudomonas aeruginosa (ATCC 99027) was applied to 25 g of the cosmetic composition of the emulsion formulation. Unit, colony forming unit)/g or more, and mixed. Subsequently, while incubating for 4 weeks in a constant temperature bath at 30°C to 32°C, 1 g of each cosmetic composition was taken at intervals of 0 days, 7 days, 14 days, 21 days, and 28 days to measure the viable cell count. In addition, the fungus was added to the mixture of anispergillus nigger (ATCC 16404) to have an initial concentration of 10 ⁵ cfu/g or more for each sample, and then mixed and incubated in a 25°C thermostat at 7 day intervals, presence of odor and sample surface Hyphae and spores were observed. The evaluation method was based on the following criteria.

-: No odor and hyphae and spores for 4 weeks, good

+: Mold on the walls or lids within 4 weeks

++: Odor and mold on part of the surface within 4 weeks

+++: Odor and mold all over the surface within 4 weeks

(1) Methyl chabicol and butylene glycol

According to the ingredients and contents shown in Table 9, a cosmetic composition of an emulsion formulation in which methyl chabicol and butylene glycol is combined was prepared.

Table 10 is a result of evaluating the preservative power for formulation examples 1, 2, 3, 4, and 5 containing methyl chabicol and butylene glycol. As shown in Table 10 below, Formulation Examples 1 to 5 all showed excellent antiseptic power against bacteria and fungi. In addition, according to the results of the antiseptic test, it is confirmed that cosmetics containing methyl chabicol and butylene glycol combinations have significantly better antiseptic properties than when using ethyl paraben and phenoxyethanol, which are cosmetic preservatives conventionally used in the past. Became.

(2) Methyl chabicol and polysorbate 40

According to the ingredients and contents listed in Table 11 below, a cosmetic composition of an emulsion formulation in which methylchabicol and polysorbate 40 is combined was prepared.

Table 12 is a result of evaluating the preservative power for formulation examples 6, 7, 8, 9, and 10 containing methyl chabicol and polysorbate 40. As shown in Table 12 below, Formulation Examples 7 to 10 showed antiseptic power against bacteria, but were only at a weak level compared to Formulation Examples 1 to 5 and Comparative Example 2. In addition, antiseptic power against mold was not observed in all of the formulation examples 6 to 10.

(3) methylchabicol and polysorbate 80

According to the ingredients and contents listed in Table 13 below, a cosmetic composition of an emulsion formulation in which methylchabicol and polysorbate 80 are combined was prepared.

Table 14 is a result of evaluating the preservative power for formulation examples 11, 12, 13, 14, and 15 containing methyl chabicol and polysorbate 80. As shown in Table 14 below, Formulation Examples 12 to 15 exhibited antiseptic power against bacteria, but were only at a weak level compared to Formulation Examples 1 to 5 and Comparative Example 2. In addition, antiseptic power against mold was not observed in all of the formulation examples 11 to 15.

(4) Butylene glycol

Additionally, in this test example, antiseptic power according to the sole use of butylene glycol was evaluated as an active ingredient.

Specifically, a cosmetic composition of an emulsion formulation containing butylene glycol was prepared according to the ingredients and contents shown in Table 15 below. The concentration of the butylene glycol was adjusted to a level of 5% by weight in the same manner as 5 in Formulation Example 1.

Table 16 is a result of evaluating the preservative power for Formulation Example 16 containing butylene glycol. As shown in Table 16 below, Formulation Example 16 did not show any preservative power against bacteria and fungi.

In view of the above results, the composition for external application for skin comprising a combination of methyl chabicol and butylene glycol, specifically, methyl chabicol as an antibacterial substance, and butylene glycol as a solvent, has a low content of alkanes. Since it exhibits excellent antiseptic and antibacterial properties while using a diol-based component, it was confirmed that it is useful as an external preparation for skin such as cosmetic compositions.

The above description of the present invention is for illustration only, and those skilled in the art to which the present invention pertains can understand that the present invention can be easily modified into other specific forms without changing the technical spirit or essential features of the present invention. will be. Therefore, it should be understood that the embodiments described above are illustrative in all respects and not restrictive.

Claims (11)

Methylchavicol of Formula 1 below, or cosmetically or pharmaceutically acceptable salts thereof
[Formula 1]

; And
As a preservative for external preparations for skin containing butylene glycol,
Preservatives for external preparations for skin, containing 2 to 9% by weight of the butylene glycol relative to the total weight of the preservatives for external use for skin.
The preservative for an external preparation for skin according to claim 1, comprising 0.1 to 2% by weight of methyl chabicol and 2 to 9% by weight of butylene glycol, based on the total weight of the preservative for external use for skin.
The method according to claim 1, Preservatives for external application for skin, containing 0.1 to 1% by weight of methyl chabicol, and 4 to 7% by weight of butylene glycol, based on the total weight of the preservative for external application for skin.
The method according to claim 1, wherein the preservative for external preparations for skin comprising methyl chabicol and butylene glycol in a weight ratio of 1.0:10.0 to 1.0:50.0.
The method according to claim 1, wherein the butylene glycol is used as a solvent, a preservative for external application for skin.
A cosmetic composition comprising a preservative for an external preparation for skin according to claim 1.
The method according to claim 6, The preservative for external preparations for skin is a cosmetic composition that is contained in an amount of 0.01 to 10% by weight relative to the total weight of the cosmetic composition.
The method according to claim 6, The cosmetic composition is a skin, emulsion, cream, sun cream, foundation, essence, gel, pack, mask pack, foam cleanser, body cleanser, softening lotion, eye liner, shampoo, rinse, soap, hair dressing agent, wool agent , Hair cream, hair styling gel, lubricant, toothpaste and cosmetic composition that is one formulation selected from the group consisting of wipes.
A pharmaceutical composition for external application for skin comprising a preservative for external application for skin according to any one of claims 1 to 5.
The pharmaceutical composition for external application for skin according to claim 9, wherein the preservative for external application for skin is contained in an amount of 0.01 to 10% by weight based on the total weight of the pharmaceutical composition for external application for skin.
The skin according to claim 9, wherein the pharmaceutical composition is one of a formulation selected from the group consisting of warning agents, linen agents, ointments, pasta agents, cataplasmase, suspension agents, emulsions, lotion agents, aerosol agents, and suppositories. Pharmaceutical composition for external use.