KR20200024204A - Oral sealing wrap having extendable property - Google Patents

Abstract

The present invention provides a multi-layered oral sealing wrap, which comprises a layer having a surface in contact with a tooth or surrounding tissue thereof, and a water-impermeable film layer which is laminated on the layer having a surface in contact with a tooth or surrounding tissue thereof, wherein the layer having the surface in contact with the tooth or surrounding tissue thereof is a membrane in which a hydrophilic polymer, and at least one selected from a wetting agent, an emulsifying agent, and a mixture thereof are mixed. The oral sealing wrap of the present invention can maintain excellent adhesive strength and attachment strength even in the presence of water.

Description

Oral sealing wrap having extendable property

The present invention relates to a product for oral care, more specifically a new form that can effectively deliver and further enhance the efficacy of drug components when delivered into the oral cavity (oral surfaces including teeth, gums and mucosal tissue). Relates to a product for oral care.

Although there are many formulations for oral care and products with various usages, the oral properties are affected by the moist environment, chewing, and conversation, so that the active ingredients applied to the teeth or gums through various formulations and methods can provide sufficient contact time to the desired area for the desired time. It is not easy to secure.

In addition to interest in teeth whitening, a lot of researches are being conducted to improve oral health by transferring drugs between the curved parts of the teeth or between the teeth and the teeth. For example, studies for preventing or treating oral diseases such as gingivitis and periodontitis by delivering anti-inflammatory or antimicrobial components into oral tooth soft tissues have been made as part of this.

On the other hand, people who are interested in whitening their teeth can buy products directly from pharmacies or marts to whiten the teeth without the help of a lot of products are on the market. It has the advantage of whitening teeth without the help of a professional and using it conveniently regardless of time or place.

However, as a disadvantage of tooth whitening products by non-professionals, the problem of insufficient whitening effect has been discussed. One of the causes is a low concentration of the whitening component delivered to the surface of the tooth, the low concentration of the whitening component is caused by the moist environment or contact with saliva as one cause.

In particular, by applying the drug in a variety of formulations, such as liquid, solid, spray, etc. to the target area of the teeth or gums in the oral cavity, the desired effect is obtained. Due to the movement, the active ingredient did not stay in the target site until the desired contact time, and thus the effect was not obtained.

The inventors of the present invention need to secure sufficient contact time in order for the efficacy ingredient to be effective for short-term use, even if the efficacy ingredient is applied to the target in various dosage forms in a wet oral cavity, it is difficult to easily remove and wash away to obtain a desired contact time. Found. In particular, the oral cavity is a safety issue, no matter how effective the effective ingredients, no matter how high concentration or large amount it is difficult to use a small amount of short-term use in order to achieve the desired effect it was realized that the need to seal the active ingredient.

In addition, there is a problem that the tooth whitening component is not delivered to the gap between the teeth or between the tooth and the teeth, the whitening effect is not achieved until the tooth gap. The reason for this problem is that products on the market have not been able to develop products that fit the shape of the individual's teeth to deliver whitening ingredients to the tooth surface or tooth gap.

International Publication No. WO 2004045569 A1 discloses a technique for uniformly producing the shape of a tooth patch in order to effectively whiten the teeth. However, such a product has a problem that effects may vary depending on the shape and shape of the user's teeth. For example, there is a problem that the gap of the tooth is wider than the shape of the tooth designed in the product, or when the actual tooth is shorter or longer than the designed tooth shape, the effect of the product cannot be fully exhibited.

In addition, these standardized tooth whitening patches require a thickness of more than a certain thickness to inevitably store a drug in order to deliver a certain amount of whitening agent that is effective for teeth whitening. There was discomfort in attachment.

On the other hand, in the case of peroxide, which is most often used as a tooth whitening component, there is a problem that the compatibility of the fragrance component and the peroxide is poor, so the industry has no choice but to limit the type and amount of perfume components used in the tooth whitening agent. However, even though the need for taste and aroma is great in the oral products that are directly tasted, the industry has not been able to provide a proper solution to this problem.

In the meantime, the industry has done a lot of research on the system for delivering drugs into the oral cavity, and in the meantime, the development of products to satisfy the needs of consumers is being actively conducted. Accordingly, the researchers of the present invention have steadily researched a system for delivering a drug into the oral cavity, and thus, completed the present invention.

The problem to be achieved by the present invention is to develop a product such as a wrap for protecting the active ingredient applied to the mouth, especially on the teeth in the mouth, such as a wrap used for storing food in a container for a long time.

The problem to be solved by the present invention is to allow the drug applied to the target site in the oral cavity to stay well for a desired time. After the drug is applied to the target site in the oral cavity, it is intended to develop a system for drug delivery that can minimize the effects of enzymes contained in saliva.

The present invention is to provide a wrap for oral cavity that can completely wrap the tooth surface and surrounding tissue after application of the composition of the gel or paste form to maintain adhesion and adhesion.

The present invention is to provide an oral wrap that can be easily removed when you want to remove the flexible but not buried in the hand before attachment but strong adhesive force caused by moisture or saliva on the target to seal the curved oral target site.

The present invention provides an oral sealing wrap for a new type of oral application that can encapsulate a target site in the oral cavity, in particular the tooth and the tissue around the tooth, and can be sealed in high oral cavity.

An embodiment of the present invention includes a layer having a surface in contact with a tooth or peripheral tissue, and includes a film layer laminated on a layer having a surface in contact with the tooth or peripheral tissue and water impermeable. The layer having a surface in contact with a tooth or tissue surrounding the tooth may include a hydrophilic polymer; And an oral sealing wrap, wherein any one selected from the humectant, the emulsifier, and a mixture thereof is a mixed membrane.

The inventors of the present invention, unlike patch formulations such as oral patches for delivering a potent ingredient (for example, a tooth whitening ingredient) to the site of the oral cavity that is difficult to apply and has a lot of bends such as teeth and tooth gaps, between teeth and gums The result of the long-term development of a new type of oral application product that can be covered and has excellent adhesion and adhesion has been achieved.

In addition, the inventors of the present invention have completed the present invention as a result of studying a product for the complete sealing of the tooth, which was not conceived in the art at all.

In general, the drug is applied through the tissue around the tooth as well as the tooth for drug delivery through the oral cavity, or drug delivery for oral application. In this case, the applied drug may cause a problem such as dilution or washing off of the drug due to a special environment in the oral cavity (eg, a humid environment, physical interference by the tongue, etc.).

One way to solve this problem is to consider a way to fully seal the teeth and tissues around the teeth, and to develop a new type of system for intraoral drug delivery.

An embodiment of the present invention includes a layer having a surface in contact with a tooth or peripheral tissue, and includes a film layer laminated on a layer having a surface in contact with the tooth or peripheral tissue and water impermeable. The layer having a surface in contact with a tooth or tissue surrounding the tooth may include a hydrophilic polymer; And an oral sealing wrap, wherein any one selected from the humectant, the emulsifier, and a mixture thereof is a mixed membrane.

The oral sealing wrap has a multi-layered structure including a membrane layer, which is a first layer having adhesiveness while absorbing moisture in contact with a tooth or surrounding tissue, and a film layer, which is laminated on the membrane, and has a second layer having moisture impermeability. Can be.

As used herein, the term "peripheral teeth" is generally a concept including a part expressed by the gum, and may be used as a meaning including all the mucosal parts of the periphery of the tooth. The periphery of the tooth may be used as a meaning encompassing a site where an agonist may be delivered together or through the oral cavity when the composition for oral cavity is applied to the tooth. Although only described as 'teeth' in this specification, it can be understood in the present specification to include all teeth or peripheral portions thereof.

The layer having a surface in contact with the tooth or surrounding tissue includes a hydrophilic polymer; And any one selected from a humectant, an emulsifier, and a mixture thereof.

As used herein, 'membrane' is a term that may be used in place of a barrier, a film, or the like, and may be understood to mean a thin layer structure. The membrane does not have adhesive strength before contact with moisture, but exhibits adhesive strength in contact with moisture, and may have sagging properties.

The membrane may comprise a hydrophilic polymer, the hydrophilic polymer may preferably be a hydrophilic glassy polymer. The hydrophilic glassy polymer may be, for example, polyalkyl vinyl ether-maleic acid copolymer (PVM / MA copolymer; Gantrez AN 119, AN 139, S-97), polyvinyl alcohol, polyacrylic acid, acrylate copolymer (Eudragit L- 100, Eudragit L-100, 55), Poloxamer 407 (Pluronic), polyethylene oxide (Polyox), polyvinylpyrrolidone-vinylacetate copolymer (PVP / VA copolymer; Luviskol VA, Plasdone S PVP / VA), polyvinylpyrrolidone (PVP, K-15-K-120), crosslinked PVP (crospovidone), Polyquaternium-11 (Gafquat 755N), polyquaternium-39 (Polyquaternium-39; Merquat plus 3330), Carbomer (Carbopol), hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methylcellulose, carboxymethylcellulose, gelatin, gelatin, Sodium alginate, carrageenan, hyaluronic acid, Gellan gum, pullulan or mixtures thereof, more preferably for the purposes of the present invention, polyvinylpyrrolidone, polyvinylalcohol, polyalkylvinylether-maleic acid copolymers, Hydroxypropylmethylcellulose, hydroxypropylcellulose, or mixtures thereof can be used.

The hydrophilic polymer may be included 10 to 35% by weight relative to the total weight of the membrane, preferably 15 to 30% by weight. It is possible to provide excellent adhesion of the membrane in the above content range.

The wetting agent included in the membrane may be any one selected from polypropylene glycol, glycerin, polyethylene glycol, sorbitol, castor oil, or a mixture thereof.

Oral sealing wraps according to an embodiment of the present invention may include a step of drying in the process of manufacturing the membrane. The membrane included in the sealing wrap may be overdried due to its thin thickness, and even if it is not overdried, if the drying loss is too low due to natural drying during storage, phase separation may occur with the water impermeable layer. Accordingly, the humectant may be contained in an amount of 2 wt% or more, preferably 2.5 wt% or more, and most preferably 5 wt% or more and 15 wt% or less, based on the dry weight of the membrane.

In one embodiment, the loss on drying of the membrane is preferably 5% or more when dried at 105 ° C. for 10 minutes as measured by Mettler Toledo HX-204 Moisture Analyzer.

The emulsifier can be used as long as it is an emulsifier that can be used in oral products, the emulsifier is Span 20, sorbitan monolaurate, Span 40, sorbitan monopalmitate, Span 60 (Span 60, sorbitan monostearate), Span 80 (Span 80, sorbitan monooleate), Span 85 (Span 85, sorbitan trioleate), Tween, POE sorbitan fatty acid ester system, polyethylene glycol, polyethylene oxide, disodium laureth sulfosuccinate, coco betaine , Decylglucoside, babasuamidopropylbetaine, cocamidopropylbetaine, tween 20, tween 40, tween 60, tween 80 or mixtures thereof. Preferably, an emulsifier having an HLB value of 10 or less may be used. For example, Span20, Span 40, Span 60, Span 80, Span 83, or the like may be used. The emulsifier may be included in 2 to 15% by weight, preferably 2.5 to 10% by weight relative to the total weight of the membrane.

As used herein, 'oral use' means that the drug can be delivered through the oral cavity, which means that it can be used not only when applied directly to the teeth, but also on tissues around the teeth such as gums in contact with the teeth. Can be.

As used herein, the term 'sealing wrap' is a formulation newly introduced by the inventor through the present invention, and may refer to a formulation in the form of a thin film having sufficient flexibility and stretchability to wind a desired target site.

The membrane does not include an agonist and may include auxiliary ingredients that may help to achieve the desired effect.

Auxiliary components that can help to achieve the desired effect of the agonist ingredient is a component that can maximize the effect of the agonist even using a small amount, for example, may include a representative catalyst.

As a specific example, the sealing wrap of the present invention including the fruit tree stabilizer and / or the fruit tree catalyst may be attached to the site where the tooth whitening component is applied to increase the tooth whitening effect. Another example is where the antimicrobial agent is applied

As used herein, the term 'active ingredient' is used as a drug, a drug active ingredient, or the like, and may mean, for example, a main ingredient exhibiting tooth whitening effect or a main ingredient exhibiting or preventing oral diseases.

Patch products containing agonistic ingredients, such as tooth whitening patches, had to carry a certain amount of agonistic ingredients and thus had a problem of maintaining a predetermined thickness or more. In addition, there was a problem that the adhesion is very poor because of the thickness.

However, the oral wrap including the membrane of the present invention can be made very thin because the type and content of the components included in the membrane is small.

The oral wrap of the present invention includes a moisture impermeable film layer provided laminated to the membrane. The water impermeable film layer may be polyethylene, polyurethane or polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer, or mixtures thereof.

The moisture impermeable film layer may preferably be polyethylene. The polyethylene has a better human safety than other films, is economical, has high elongation, is not easily torn (excellent in tensile strength), and unlike other water impermeable materials, the polyethylene has a high adhesion to the membrane containing hydrophilic glassy polymer. It is easy and can be used particularly advantageously in the wrap of the thin multilayer structure of the present invention.

The polyethylene may preferably be Low Density Polyethylene (LDPE).

As used herein, oral sealing wraps are required to have properties that can be firmly fixed and provide adhesion to teeth while being stretchable in terms of intraoral application.

In addition, the sealing wrap of the present invention requires a specific tensile force in consideration of all physical obstacles (for example, the tip of the tongue or food, etc.), humidity, etc. in order to apply in a special condition, oral cavity.

The sealing wrap of the present invention may have a tensile strength of 0.1 kgf (0.98 N) to 2.0 kgf (19.6 N) measured by a Zwick 1120 tensile testing machine, preferably 0.15 to 1 kgf.

When having the tensile strength, it is possible to minimize the phenomenon that the wrap is peeled or drooped while having stretchability to easily adhere to the tooth surface.

The membrane according to an embodiment of the present invention may have an adhesive force of 50 gmf to 300 gmf, preferably 70 to 300 gmf.

The adhesion can be measured at 25 ℃ room temperature.

The adhesion of the membrane may be measured by the MTT175 Miniature Tensile Tester, and may be measured by measuring the adhesion of a sheet, film, or the like product in the industry.

The sealing wrap according to an embodiment of the present invention may have a thickness of 100 μm or less, preferably 80 μm or less, more preferably 50 μm or less, most preferably 1 μm or more and 45 μm or less.

The thickness may be measured by a micrometer for measuring thickness generally in the industry, for example, by using a Mitutoyo Micrometer.

It is possible to maintain flexibility while minimizing foreign matter in the above range.

Another embodiment of the present invention, the oral sealing wrap of the multi-layer structure; And it provides a kit for delivering a drug to the oral cavity, comprising a composition for treating or preventing tooth whitening or oral disease comprising a potent ingredient for treating or preventing tooth whitening or oral disease delivered to the tooth or tissue around the tooth. .

The tooth whitening or oral disease treatment or prevention composition may be applied to one side of the oral sealing wrap of the multilayer structure and transferred to a tooth or tissue around the tooth.

In another embodiment, the tooth whitening or oral disease treatment or prophylactic composition is applied to a tooth or surrounding tissue, and the oral sealing wrap may be applied thereon, and is not necessarily limited to being applied to a sealing wrap. If not, any form of providing both the sealing wrap and the composition in the oral cavity can be achieved using the kit.

Preferably the composition may comprise a composition for tooth whitening, the composition for tooth whitening comprises a tooth whitening component, the tooth whitening component is hydrogen peroxide (hydrogen peroxide), carbamide peroxide, calcium peroxide (calcium peroxide, perborate, percarbonate, peroxyacids, peroxyacids, persulfates, calcium chlorite, barium chlorite, magnesium chlorite ), Lithium chlorite, sodium chlorite, or mixtures thereof. Any ingredient used in the industry for tooth whitening may be used without limitation and should not be construed as being limited to the above ingredients. Do not.

The active ingredient for treating or preventing the oral disease may be dry mouth, bad breath removal, gingivitis and periodontitis, or a tooth decay treatment or preventive ingredient, and any ingredient used to prevent or treat oral diseases in the industry may be used without limitation. .

For example, triclosan, chlorhexidine, alexidine, hextidine, sanguinarine, benzalkonium chloride, salicylanilide, and bromide Antimicrobial agents, including pen (domiphen bromide), cetylpyridinium chloride (CPC), tetradecylpyridinium chloride (TPC) or mixtures thereof; Anti-inflammatory agents including aspirin, ketorolac, flurbiprofen, pyroxicam, meclofenamic acid, or mixtures thereof; Or thiamine, riboflavin, nicotinic acid, nicotinic acid, pantothenic acid, pyridoxine, biotin, folic acid, vitamin B12, vitamin B12, lipoic acid ), Ascorbic acid, vitamin A, vitamin D, vitamin E, vitamin K or mixtures thereof; Or mixtures thereof, but is not limited thereto. In addition, corn unchecked quantitative extract, thick extract, myrrh, latania, chamomile, polycrezolene, centella quantitative extract nutmeg extract, dexanthenol, beta-sitosterol, acetyl salicylic acid (acetyl Drugs effective for preventing and improving periodontal disease such as salicylic acid) may be included alone or in a ratio. A syrup containing zinc chloride, potassium phosphate, potassium diphosphate, calcium chloride, oxalic acid, potassium oxalate, ferric oxalate, vitamin E, or the like alone or two or more may include a symptom improving and alleviating component.

In the oral drug delivery kit, a tooth whitening or oral disease treatment or prophylactic composition comprising an effective ingredient for tooth whitening, or oral disease treatment or prevention, which is delivered to a tooth or surrounding tissue, the patch (drug) It includes all formulations that are stored and released to the attached site, and may be termed films, strips, etc.), and all common formulations used to deliver drugs into the oral cavity, such as gels, pastes, liquids, sprays or ointments. It may include, and the formulation is not particularly limited.

One embodiment of the present invention provides a kit for whitening teeth comprising a multi-layer oral sealing wrap, and a composition for whitening teeth. The oral sealing wrap of the multilayer structure may further include a tooth whitening aid in the membrane in contact with the teeth.

As used herein, the tooth whitening aid itself is inadequate in exhibiting a tooth whitening effect, but it can be understood to mean a component that enhances the whitening efficacy when used with the tooth whitening component.

For example, it may include a component that helps to improve the whitening effect of the tooth whitening component, may include a fragrance component to reduce the unpleasant taste of the tooth whitening component, and to improve the stability of the tooth whitening component It may include a component used as, may include a component used for the purpose of reducing irritation caused by the tooth whitening component.

Specifically, the tooth whitening kit may be provided by including a tooth whitening component having a tooth whitening effect not included in the oral sealing wrap of the multilayer structure, but included in a separate tooth whitening composition. The separate tooth whitening composition includes patches (ie, all formulations that store the drug and release it to the attached site, and may be named films, strips, etc.), gels, pastes, liquids, sprays, or ointments. It may be provided in a formulation such as.

The tooth whitening kit provided in the embodiment of the present invention may be provided with a very thin thickness because it may be provided without including the tooth whitening efficacy ingredient in the oral sealing wrap of the multilayer structure. The tooth whitening composition included in the tooth whitening kit may preferably include a peroxide as a tooth whitening efficacy ingredient exhibiting tooth whitening efficacy.

The tooth whitening aid included in the membrane in contact with the tooth may be provided alone or in combination with any one or more selected from a pH adjusting agent, a peroxide catalyst, a photocatalyst, a fruit water stabilizer, and a mixture thereof.

The pH adjusting agent may generate perhydroxy radicals by reacting with a peroxide to enhance tooth whitening effect. For example, sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, and citric acid Sodium and one or more selected from the group consisting of EDTA-4Na can be used, but are not limited thereto. The pH adjusting agent may be used in an appropriate amount such that the pH of the composition is 8-11.

The peroxide catalyst is a component capable of promoting the decomposition of the peroxide, for example, selected from the group consisting of magnesium chloride, magnesium gluconate, iron lactate, iron gluconate chloride, manganese sulfate, manganese gluconate, manganese chloride and manganese citrate One or more may be used, but is not limited thereto.

The photocatalyst may be titanium dioxide (TiO ₂ ) or the like, but is not limited thereto.

The fruit water stabilizer may be used as a condensation phosphate, usable condensation phosphate, sodium pyrophosphate (TSPP), sodium pyrophosphate (SAPP), sodium polypolyphosphate (STP) , Sodium potassium pyrophosphate, potassium pyrophosphate, tetrapotassium pyrophosphate, acidic sodium metaphosphate, acidic sodium polyphosphate, or one or two or more kinds thereof may be used. .

The oral sealing wrap of the multi-layer structure may further include a fragrance, gum protection components and the like as a tooth whitening aid to the membrane in contact with the teeth.

As the fragrance which can be included in the sealing wrap, in general, the fragrance used in the product for oral care can be used without limitation, for example, a substance used in fragrance material and food fragrance, such as peppermint oil, menthol, spearmint Flavors such as oils, carbons, anise oils, anitol, eucalyptus oils, clove oils, eugenol, wintergreen oils, methylsalicylates, cinnamon oils, cinnamicaldehydes and the like.

The gum protection component is a component that can alleviate the stimulation caused by the tooth whitening component, for example, an amino acid including methionine, cysteine and taurine; Organic acids including ursodeoxycholic acid and tauroursodeoxycholic acid; And at least one oral irritation-reducing component selected from the group consisting of vitamins including vitamins A, C, and E, and preferably, amino acids including methionine, cysteine, and taurine may be used.

The oral sealing wrap of the multi-layer structure itself enhances the tooth whitening efficacy of the tooth whitening composition containing the tooth whitening component (for example, hydrogen peroxide, etc.), rather than exhibiting tooth whitening efficacy, or in view of the use of the composition for tooth whitening Ingredients that can enhance convenience, improve the feel of the tooth whitening composition, and the like can be added.

The tooth whitening aid may be included in an amount of 0.1 to 12% by weight, preferably 0.3 to 10% by weight, based on the total weight of the membrane.

When including the content range, the kit is made thinner (100 μm or less) in thickness of the sealing wrap while improving the tooth whitening efficacy, it is advantageous to achieve the object of the present invention.

The present invention can protect the agonist applied in the oral cavity from being diluted in saliva, washed out, or physically removed by the tongue.

The present invention may allow the drug applied to the target site in the oral cavity to stay well for a desired time. After the drug is applied to the target site in the oral cavity can provide a system for drug delivery that can minimize the effects of enzymes contained in saliva.

The present invention provides a wrap for oral cavity that can completely wrap the tooth surface and surrounding tissue after application of the composition in the form of gel or paste to maintain adhesion and adhesion.

The present invention provides an oral wrap that is flexible and can be easily removed when it is not buried in the hand but is strongly adhered by moisture or saliva on the target to seal and remove the target site in the curved oral cavity.

Hereinafter, the following examples and the like will be described in order to describe the present invention in more detail. However, embodiments according to the present invention may be modified in many different forms and the scope of the present invention should not be construed as being limited to the embodiments described below. Embodiments of the present invention are provided by way of example in order to facilitate a specific understanding of the present invention. Unless otherwise stated,% described herein may be understood to mean weight percent.

[For oral cavity Shilling Lab's  Produce]

The oral sealing wraps of the two-layer structure of Examples and Comparative Examples having the following compositions were prepared.

Example 1 Example 2 Example 3 Example 4 1 ^st Layer Glycerin 3.0%
PVP 21.0%
Flavor 2.0%
SPAN80 1.0%
Ethanol to 100% PEG 10.0%
PVA 20.0%
SPAN80 5.0%
Water to 100% Glycerin 3.0%
HPMC 10.0%
Gantrez 10.0%
SPAN80 3.0%
FeCl3 0.5%
NaOH pH to 10
Water to 100% Glycerin 8.0%
HPC 15.0%
Pullulan 3.0%
SPAN80 5.0%
Ethanol to 100% 2 ^nd Layer PE Film Ethyl Cellulose 20.0%
Castor oil 5.0%
Ethanol to 100% Polyurethane Film PE Film Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 1 ^st Layer none none none Ethyl Cellulose 20.0%
Castor oil 5.0%
Ethanol to 100% 2 ^nd Layer PE Film Ethyl Cellulose 20.0%
Castor oil 5.0%
Ethanol to 100% Polyurethane Film PE Film

Physical properties were measured for Examples 1-4 and Comparative Examples 1-4.

[Property confirmation]

The thickness of Example 1-4 was measured.

Less than 100um thick: no foreign matter, not disturbed by daily life.

If a potent ingredient is contained, it is difficult to make it thin unconditionally because the concentration and amount of the potent ingredient are affected, but this wrap can be made thin enough because the main purpose is to wrap it.

The adhesion between before and after hydration of Example 1-4 was measured.

Adhesion to the teeth (adhesion) was measured using a miniature tensile tester. The adhesion to the teeth in the dry state was measured by the wrap's adhesion to the fully dried hydroxyapatite tablet, and the adhesion after hydration was primarily applied to the hydroxyapatite tablet to mimic a wet mouth. After the addition, the excess moisture was removed using a tissue and the adhesive strength of the wrap was measured after applying the first agent used together with the second time. The adhesive force of the wrap tooth was measured by pressing the hydroxyapatite tablet with the wrap for a certain time with a constant contact force and then taking off the wrap.

▶ Tensile strength of Examples 1-4 and Comparative Examples was measured.

Wrapped in the target area and removed after tearing, it is neatly removed without tearing.

[ To feel  Evaluation of

1. Characteristics of wraps for panel in laboratory Feeling  Survey Evaluation

Wrap was used twice in both the maxillary six teeth and the mandibular six teeth, and the example and the comparative example were used twice, and then responded to the stiffness, adhesion, adhesion, and the like. A 10-point scale was used to respond, with 10 being the highest value. The panel evaluated ten candidates, regardless of age.

Initial adhesion Adhesion after hydration Initial strength Strength after hydration Example 1 2 10 6 2 Example 2 2 8 6 2 Example 3 2 8 5 2 Example 4 2 8 6 2 Comparative Example 1 2 2 6 6 Comparative Example 2 2 2 6 6 Comparative Example 3 2 2 5 5 Comparative Example 4 2 2 6 6

[Comparison of Efficacy Effects of Use Examples and Comparative Use Examples According to Method of Use]

Example 1
Spray + Wrap Example 2
Paste + Wrap Example 3
Gel + Wrap Example 4
Patch + Wrap 1: Bad breath spray
(Amway Glister Mouse Spray)
2nd: Wrap (Example 1) Agent 1: Paradontax
2nd: Wrap (Example 2) Preparation 1: Tooth Whitening Gel
(Median White White Teeth White Gel)
2nd: Wrap (Example 3) Agent 1: patch
(P & G Sensi-Stop)
2nd: Wrap (Example 4)

Comparative Example 1 Spray only

Comparative Example 2 Paste only

Comparative Example 3 Gel only

Comparative Example 4 Strip Only

One) Example 1 Comparative Example  1, consumer usability Get rid of bad breath as an assessment and Refreshing  compare

2) Example 2 and Comparative Example 2  Comparison of gingivitis mitigation effects by consumer usability assessment

3) Example 3 Comparative Example 3  Comparison of tooth whitening effect by consumer usability assessment

4) Example 4 and Comparative Example 4  As a consumer usability assessment Sirin  Comparison of Symptom Relief Effects

Panel Evaluation

1. Eliminate bad breath for the panel in the lab Refreshing  Sustainability Survey

1) Test subject and how to use : Use Example 1 and Comparative Example 1 do not drink water or drink separately after 1 hour after eating 3 times a day, or eat snacks, spray the mouse as usual (Amway Glister Mouse in this experiment) After the use of the spray), use example 1 covered six maxillary anterior teeth with the wrap of example 1, and the comparative example did not perform any separate treatment.

The experiment panel was recruited to 10 volunteers in their 20s, and after using Example 1 for one day (three times) and Comparative Example 1 for one day (three times), the survey was conducted according to the following scale. It was.

2) Satisfaction assessment (5 points of satisfaction for each question, 5 points of satisfaction, 4 points of satisfaction, 3 points of normal, 2 points of dissatisfaction, and 1 point of very dissatisfaction).

The ease of use in the questionnaire is the convenience of the method of use, and the feeling of use / wearing is satisfied with the feeling of feeling when using each one in the oral cavity, a feeling of foreign body or unwanted areas such as hands or lips, or disappearing easily. Asked.

(Evaluation results)

Ease of Use Feeling /
Fit Bad breath
effect Refreshing Persistence Overall satisfaction Example 1 4 5 5 5 4.5 compare
Example 1 5 3 3.5 3 3

2. Survey of gingivitis mitigation effects on panel in the institute

1) Test subject and usage : Use Example 2 and Comparative Example 2 were used paradontax ointment in the place where gingivitis is felt when feeling gingivitis twice a day. Use Example 2 was covered with a wrap of Example 2 as if the teeth and gums on the site covered with ointment, Comparative Example 2 was not a separate treatment. The same method was used for a month.

For the experiment panel selection, 10 people were recruited from 50 volunteers in the institute. It was.

2) satisfaction evaluation

The ease of use in the questionnaire is the convenience of the method of use, and the feeling of use / wearing is the feeling, the adhesion, the foreign body or the unwanted discoloration of the unwanted parts such as the hands or lips, etc. I asked about overall satisfaction.

(Evaluation results)

Ease of Use Feeling / wearing feeling Gingivitis Overall satisfaction Example 2 4.5 5 5 4.5 compare
Example 2 3.5 2.5 3 3

3. Evaluation of tooth whitening sensation effect on panel in the institute

1) Test subjects and how to use : Use Example 3 and Comparative Example 3 were to use the whitening gel on 6 of the upper teeth for 30 minutes in the morning and afternoon twice a day. Use Example 3 was wrapped in the wrap of Example 3 as if the teeth and gums wrapped around the whitening agent, Comparative Example 3 did not have a separate treatment. The same method was used for a month.

In the experiment panel selection, 10 people were recruited from the 30 volunteers in the institute, 5 people were using only Example 3, 5 were using Comparative Example 3, and the satisfaction was surveyed according to the following scale.

2) satisfaction evaluation

The ease of use in the questionnaire is the convenience of the method of use, and the feeling of use / wearing is the feeling, the adhesion, the foreign body or the unwanted discoloration of the unwanted parts such as the hands or lips, etc. I asked about overall satisfaction.

(Evaluation results)

Ease of Use Feeling / wearing feeling Teeth brighten (feel whitening) Overall satisfaction Example 3 4 5 5 5 compare
Example 3 5 2 3 3

4. For panels in the institute Sirin  Mitigation Effect Survey Evaluation

1) Test subject and how to use : Example 4 and Comparative Example 4 was used once a day for 10 minutes in the site where the symptom of symptom is felt. In Example 4, the SensiStop syringe of P & G wrapped the teeth and gums on the right part where the strip was attached using the wrapper of Example 4, and Comparative Example 2 was not treated separately. The same method was used for a month.

For the experiment panel selection, 10 people were recruited from 50 volunteers in the institute, 5 people used only 3 times of use example 4, 5 people used only 3 times of comparative use example, Survey was conducted.

2) satisfaction evaluation

The ease of use in the questionnaire is the convenience of the method of use, and the feeling of use / wearing is the feeling, the adhesion, the foreign body or the unwanted discoloration of the unwanted parts such as the hands or lips, etc. I asked about overall satisfaction.

(Evaluation results)

Ease of Use Feeling / wearing feeling A symptom feels relief Overall satisfaction Example 4 3 5 5 5 compare
Example 4 4 2 3 3

[Example]

1.Flavor Long-Lasting Function :

As it is manufactured in a multi-layer structure, you can put the desired flavor, pattern, and color unlike the general wrap. In particular, in the oral cavity, chewing gum, spraying, or using goggles for the purpose of improving bad breath, etc. The moment of using the product is refreshing, but there are problems that are restored to its original state. If you do, the flavor will continue to be released, giving you a refreshing feeling as if you are still chewing gum.

2. Synergistic function of whitening effect: It is difficult to use with the peroxide and compatibility due to the problem of Stability, but by using the wrap together than the single formulation by using the peroxide activator in a separate wrap. You can get it.

3. Add cosmetic function: It provides the effect to add cosmetic function while attaching by wrapping desired pattern or pattern in wrap.

Claims (19)

A layer having a surface in contact with the tooth or surrounding tissue,
A film layer laminated on a layer having a surface in contact with the tooth or the tissue surrounding the tooth and being water impermeable,
The layer having a surface in contact with the tooth or the surrounding tissue includes a hydrophilic polymer; And a wetting agent, an emulsifier, and a mixture thereof, wherein the selected one is a mixed membrane. The method of claim 1, wherein the hydrophilic polymer is a polyalkyl vinyl ether-maleic acid copolymer, polyvinyl alcohol, polyacrylic acid, acrylate copolymer, poloxamer, polyethylene oxide, polyvinylpyrrolidone-vinylacetate copolymer, polyvinyl Pyrrolidone, crospovidone, polyquaternium, carbomer, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropyl cellulose, methylcellulose, carboxymethyl cellulose, gelatin, sodium alginate, carrageenan, hyaluronic acid, Gellan gum, pullulan and mixtures thereof, characterized in that any one selected from the group consisting of, oral sealing wrap of a multi-layer structure. According to claim 1, The oral sealing wrap of the multi-layer structure, characterized in that the adhesive strength measured by MTT175 Miniature Tensile Tester at 25 ℃ room temperature is 50 gmf to 300 gmf, multi-layer oral sealing wrap. The oral sealing wrap of claim 1, wherein the wetting agent is any one selected from the group consisting of polypropylene glycol, glycerin, polyethylene glycol, sorbitol, castor oil, and mixtures thereof. The method of claim 1, wherein the membrane comprises a humectant 2 to 15% by weight based on the total dry weight of the membrane, the drying loss of the membrane after drying for 10 minutes at 105 ℃, characterized in that more than 5% Sealing wrap. The method of claim 1, wherein the emulsifier is Span 20, Span 40, Span 60, Span 80, Span 85, Twin system, Polyethylene glycol, Polyethylene oxide, Disodium laurethsulfosuccinate, Coco betaine, Decylgcoside , Babasuamidopropylbetaine, cocamidopropylbetaine, Tween 20, Tween 40, Tween 60, Tween 80, and mixtures thereof, characterized in that any one selected from the group consisting of, oral sealing wrap of a multi-layer structure. The oral sealing wrap of claim 1, wherein the oral sealing wrap has a tensile strength of 0.1 kgf (0.98 N) to 2.0 kgf (19.6 N) measured by a Zwick 1120 tensile testing machine. Sealing wrap. The oral sealing wrap of claim 1, wherein the membrane does not include an agonist. The method of claim 1, wherein the material of the water impermeable film layer is polyethylene, polyurethane, polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine / methacrylate copolymer, and these The oral sealing wrap of any one of, characterized in that any one selected from the group consisting of a mixture. 10. The oral sealing wrap of claim 9, wherein the water impermeable film layer is polyethylene. The oral sealing wrap of claim 1, wherein the oral sealing wrap of the multilayer structure has a thickness of 100 μm or less. Oral sealing wraps of any one of claims 1 to 11; And
Tooth whitening or oral disease treatment or prevention comprising a composition for the treatment or prevention of teeth comprising a whitening or
The tooth whitening or oral disease treatment or prevention composition is applied to the oral sealing wrap of the multi-layer structure or teeth or tissue around the tooth, oral drug delivery kit. The method of claim 12, wherein the tooth whitening active ingredient, wherein the tooth whitening component is hydrogen peroxide, urea peroxide, calcium peroxide, perborate, percarbonate, peroxy acid, persulfate, calcium chlorite, barium chlorite, Oral drug delivery kit, characterized in that any one selected from the group consisting of magnesium chlorite, lithium chlorite, sodium chlorite and mixtures thereof. The method of claim 12, wherein the oral disease therapeutic or prophylactic ingredient is dry mouth, bad breath removal, gingivitis and periodontitis, or caries treatment or prevention component, oral drug delivery kit. The method of claim 12, wherein the tooth whitening or oral disease treatment or prevention composition comprising an effective ingredient for the treatment or prevention of teeth whitening or oral disease is delivered to the tooth or surrounding tissue is a patch, gel, paste, liquid, Oral drug delivery kit, characterized in that any one or more selected from the formulation consisting of a spray, and ointment. Oral sealing wraps of any one of claims 1 to 11; And
Tooth whitening composition,
The oral sealing wrap of the multilayer structure is characterized in that it further comprises a tooth whitening aid on the membrane in contact with the teeth, teeth whitening kit. The tooth whitening kit of claim 16, wherein the tooth whitening aid is used singly or in combination of a pH adjusting agent, a peroxide catalyst, a photocatalyst, a fruit water stabilizer, and a mixture thereof. 18. The method of claim 17, wherein the pH adjusting agent is at least one selected from the group consisting of sodium hydroxide, potassium hydroxide, sodium phosphate, disodium phosphate, trisodium phosphate, sodium pyrophosphate, sodium citrate, and EDTA-4Na,
The peroxide catalyst is at least one selected from the group consisting of magnesium chloride, magnesium gluconate, iron lactate, iron gluconate chloride, manganese sulfate, manganese gluconate, manganese chloride and manganese citrate,
The photocatalyst is titanium dioxide,
The fruit tree stabilizer is at least one member selected from the group consisting of sodium pyrophosphate, acidic pyrophosphate, sodium polyphosphate, potassium pyrophosphate, potassium pyrophosphate, acidic metapolyphosphate, and acidic polyphosphate , Tooth whitening kit. The tooth whitening kit of claim 16, wherein the multi-layer oral sealing wrap further comprises a flavourant and a gum protection component on a membrane in contact with the tooth.