KR20190111285A - Composition for promoting pregnancy and method for producing the same - Google Patents

Abstract

The present invention relates to a composition for improving fertility, which comprises: a rice bran extract; inositol; coenzyme Q-10; selenium; and vitamin C. The composition for improving fertility according to the present invention uses nature-derived components to improve irregular menstrual cycles and ovulation, thereby improving menstrual irregularities and irregular ovulation cycles.

Description

Composition for improving fertility and its manufacturing method {COMPOSITION FOR PROMOTING PREGNANCY AND METHOD FOR PRODUCING THE SAME}

The present invention relates to a composition for improving fertility and a method for producing the same. More specifically, the present invention includes fermented rice bran extract to increase fertility between fertilized eggs and endometrial cells and fetal-derived trophoblast cells, so that implantation of fertilized eggs can be made more stably. The composition for this and its manufacturing method.

In recent years, with the aging society, infertility is increasing as the age of mothers giving birth increases. In addition, as the stress on women increases due to environmental pollution due to industrialization and social advancement of women, the pregnancy rate is significantly reduced.

Common causes of female infertility include ovulation disorders, fertilization of fertilized eggs and implantation disorders. Infertility problems due to ovulation disorders and fertilization of fertilized eggs are mostly solved through IVF, but infertility due to implantation disorders has not been clearly resolved.

Implantation of the fertilized egg involves first step of removing the zona pellucida of the fertilized egg, second inducing a loose apposition between the fertilized egg and the endometrium, and third, inducing strong adhesion of the fertilized egg and the endometrium. , And the fourth fertilized egg bound to the uterine inner wall is invaded into the endometrium (invasion). Expression of the leukemia inhibitory factor (LIF), a cytokine of the IL-6 family, is known to play an important role in this implantation process. In mice lacking LIF, the second stage normally proceeds, but the third stage of the adhesion process results in aberration of the fertilized egg (Nature. 359 (6390): 76-9, 1992; Endocrinology 150 (6): 2915-23, 2009). In addition, the use of an antagonist against LIF to inhibit the function of LIF does not cause implantation (PNAS 104 (49): 19357-62, 2007; Contraception S0010-7824 (12) 00884-0, 2012) It has been reported that the LIF is attracting attention as a factor that plays a key role in the conception of fertilized eggs.

On the other hand, it is important to induce regular ovulation to women of childbearing age before the fertilized egg implantation stage as described above. Human Chorionic Gonadotropin (hCG) for use in promoting ovulation in general; Follicle Stimulating Hormone (FSH); Human menopausal gonadotropin (hMG); Direct injections of hormones such as gonadotropin releasing hormone (GnRH) can be used, but these are the hormones used to control ovulation or to induce overovulation in women with irregular ovulation cycles and to improve irregular ovulation. There is a limit. In addition, there is a problem that a problem of side effects due to the use of hormonal agents occurs.

These irregular ovulations are due to oxidative stress and other environmental factors. In order to improve fertility of women with irregular ovulation, a method of reducing oxidative stress with improvement of living environment should be mobilized.

To improve female fertility, identify alterable factors that reduce oxidative stress in a gynecological environment, eliminate side effects, and improve the irregular ovulation of fertilized eggs using long-term natural products This completes the excellent natural invention.

KR 10-2016-0093638 A

It is an object of the present invention to provide a fertility-improving composition that allows the irregular menstrual cycle and ovulation to be wired using a natural-derived component to improve menstrual irregularities and irregular ovulation cycles.

The fertility-improving composition is a natural-derived component has almost no problem of side effects, so that it can be taken for a long time to make a great effect in improving menstrual irregularities and irregular ovulation cycle.

Another object of the present invention is to provide a method for preparing the composition for fertility improvement.

In order to achieve the above object, the composition for fertility improvement according to an embodiment of the present invention is rice bran extract; Inositol; Coenzyme qtene; And selenium and vitamin C.

The fertility-improving composition may further include a first plant extract containing three hundred s. Extract.

The fertility-improving composition may further include a second plant extract containing ginseng extract.

In the fertility-improving composition, the first plant extract may further comprise a barberry extract.

In the fertility-improving composition, the rice bran extract is a rice bran powder and hot water mixture, Aspergillus oryae, Bacillus licheniformis, Bacillus licheniformis, Pichia farinosa and their It may be fermented by inoculating any one selected from the group consisting of a mixture.

Food according to another embodiment of the present invention may be to include the composition for improving fertility.

According to another embodiment of the present invention, a method for improving fertility composition is prepared by pulverizing rice bran to prepare rice bran powder, and mixing the rice bran powder with hot water, aspergillus duckwood (Aspergillus oryzae), Bacillus richenimomis Preparing an extract by inoculating and fermenting any one selected from the group consisting of Bacillus licheniformis, Pichia farinosa, and mixtures thereof; A first plant extract mixing step of preparing a mixed composition by mixing the first plant extract comprising three hundred s. Extract with the rice bran extract and after mixing the ginseng extract to the mixed composition after the first plant extract mixing step to prepare a mixed composition It may be to include a second plant extract mixing step.

In the method for producing a fertility-improving composition, the first plant extract may further include a barberry extract.

Hereinafter, the present invention will be described in more detail.

Composition for improving fertility according to an embodiment of the present invention is rice bran extract; Inositol; Coenzyme qtene; And selenium and vitamin C.

Composition for improving fertility in the present invention refers to improving fertility and irregular menstrual cycle to improve the fertility of women by having a certain ovulation cycle. In addition, the fertility in the present invention refers to the fertility ability, by improving the body environment that allows the woman to conceive means an effect that the possibility of pregnancy of the woman is increased.

Rice bran as used in the present invention refers to fine sesame which is separated in a process of extracting rice hull from rice and then turning brown rice into white rice.

The rice bran extract refers to an extract of crushed rice bran using hot water. When the rice bran extract is used in combination with other mixtures, the menstrual irregularities may be improved and the menstrual cycle may be regularly improved.

Inositol refers to a chemical consisting of the formula C ₆ H ₁₂ O ₆ . It is crystalline and sweet like sugar, and naturally exists in four kinds of myoinositol, D-inositol, L-inositol and siloinositol. Among these, myoinositol is a compound called mesoinositol or inositol, which is in a free form and is present in an animal body such as muscle, heart, and liver, and is present as a component of inositol phospholipid in the liver and brain of a mammal.

The inositol may improve the effect of improving the follicle quality when used in combination with the rice bran extract may have the effect of increasing the fertility of women.

Also coenzyme qtene; Selenium and vitamin C generally have good antioxidant activity. Just coenzyme qtene; Antioxidant activity of selenium and vitamin C alone is difficult to achieve the effect of improving the follicles to improve the regular menstrual cycle. The coenzyme qtene; Selenium and vitamin C, when used in combination with the rice bran extract, the antioxidant activity is rapidly increased to improve the follicle quality as an effect of the interaction and may improve the irregular ovulation cycle when taken for a certain period of time.

Preferably the composition for improving fertility comprises a rice bran extract, 1 to 10 parts by weight of inositol, 1 to 10 parts by weight of coenzyme cutene, 0.5 to 8 parts by weight of selenium and 0.5 to 8 parts by weight of vitamin C based on 100 parts by weight of the rice bran extract It may be to include.

In the above range, the follicle quality is improved by synergistic effects due to interactions, and the effect of improving menstrual irregularities and restoring regular ovulation cycles can be significantly increased.

The fertility-improving composition may further include a first plant extract containing three hundred s. Extract.

Samururus chinensis (Lour.) Baill. Is a perennial herb from Jeju and parts of Jirisan. The growing environment grows in a well-ventilated, high-humidity, half-shaded valley of damp valleys. The height is 50 to 100 cm, the leaves are 5 to 15 cm in length, 0.3 to 0.8 cm in width, long oval, and alternate. The leaf surface is light green, the back side is light white, and when the flowers bloom, the upper leaves 2 or 3 turn white, with 5 to 7 veins, the ends are pointed, and the edges are flat. Roots grow white, digging into the soil and extending to the side. Flowers sag down to white, the end of which rises up to face the leaves, the length is 10-15cm, and the hair is curly. Fruits round one by one on September or October. It is used for ornamental purposes, and leaves and stem roots including flowers are used as medicinal herbs.

When the first plant extract contains three hundred sec extract, the effect of alleviating menstrual irregularities is enhanced, and the activity of the active ingredient which improves irregular menstrual cycle and ovulation cycle regularly by improving follicle quality is increased, thereby improving fertility You can.

The fertility-improving composition may further include a second plant extract containing ginseng extract.

Including the second plant extract containing the ginseng extract has the advantage of increasing the antioxidant activity and improving the ovulation cycle by improving the body environment of the woman.

Preferably in the fertility improving composition, the first plant extract may further comprise a barberry extract.

Aquilegia buergeriana Siebold & Zucc.var.oxysepala is a perennial plant that grows in sunny valleys and meadows throughout the country. It is grown in China, Japan, and northeastern Russia. Stems are branched, smooth and purple, 30-130 cm high. Root leaves are gathered in several sheets, petiole is long, and divided into 2 and 3 branches. Stem leaf is double leaf, with petiole shorter upward. Flowers run downwards at the end of May-July branches, yellowish purple. Calyx leaves are 5 sheets, looking like petals, and are brownish purple. Petals are 5 sheets, yellow, alternate with calyx leaves. There is a beneath the petal, with the ends bent inward and out. There are many stamens, and the inner one is a flat surgery without anther. Pistil has 5, fruit is bone, running upward.

Including the extract of the claws may improve the follicles and improve the menstrual irregularity and other irregular menstrual cycles regularly so that regular ovulation can be activated according to the menstrual cycles.

Preferably the second plant extract may further comprise a jade extract.

Bibichu (Hosta longipes (Franch. & Sav.) Matsum) grows well in mountain streams and in damp areas. It is 30-40 cm in height. The leaves all sprout from the roots and grow at an angle. The leaves are elliptical, pointed at the end, and have 8 or 9 veins. The flowers are light purple, bloomed in July or August, slanted to one side, running in a gunshot, and the stalk is 30-40 cm long. A bract is thin membranous, purplish white, almost the length of a petiole. The corolla is split into six ends, and the forked piece is flipped back slightly. Six stamens and one pistil come out of the flower for a long time. Fruits are long oval, with capsules. Seeds are black with wings at the edges. Edible light edible planted for ornamental purposes. Wild species are distributed in Korea, Japan, and China.

In the case of further comprising the jade extract, the effect of improving the ovulation cycle can be increased by using a relatively small amount of the composition, thereby eliminating the problem of side effects due to long-term use.

Preferably the possible improvement composition comprises a rice bran extract and contains 1 to 10 parts by weight of inositol, 1 to 10 parts by weight of coenzyme cutene, 0.5 to 8 parts by weight of selenium and 0.5 to 8 parts by weight of vitamin C based on 100 parts by weight of the rice bran extract. A first plant extract comprising 1 to 10 parts by weight and 0.1 to 3 parts by weight of claw extract, based on the rice bran extract; It may be to include a second plant extract containing 5 to 20 parts by weight of ginseng extract and 1 to 10 parts by weight of jade extract.

According to the above range, the follicle-improving effect is most excellent, and the effect of regularly improving the ovulation cycle even with a small content is excellent, and there is no problem of side effects even when taken for a long time. In particular, when the rice bran extract is fermented, there is a problem that palatability is lowered due to its peculiar fermentation odor. According to the above range, the flavor due to the interaction of each extract can be improved, thereby providing a more palatable functional food. Has the advantage.

In the fertility-improving composition, the rice bran extract is a rice bran powder and hot water mixture, Aspergillus oryae, Bacillus licheniformis, Bacillus licheniformis, Pichia farinosa and their It may be fermented by inoculating any one selected from the group consisting of a mixture.

When fermenting the rice bran extract further enhances the antioxidant activity with each mixture, and improves the follicle quality to eliminate the physiological impurities and to enhance the effect of fertility by regular ovulation.

Preferably, the microorganism may be fermented with Bacillus licheniformis (Bacillus licheniformis). When fermented by the strain, the synergistic effect of the interaction can be greatly enhanced by the increase of the active ingredient to increase the above-mentioned effect by the interaction.

Food according to another embodiment of the present invention may be to include the composition for improving fertility.

The food referred to in the present invention is defined as containing general foods, beverages as well as health functional foods.

According to another embodiment of the present invention, a method for improving fertility composition is prepared by mixing rice bran powder in hot water and aspergillus duckwood (Aspergillus oryzae), Bacillus licheniformis (Pycillin pariniosa) Pichia farinosa) and inoculating and fermenting any one selected from the group consisting of to prepare a rice bran extract; A first plant extract mixing step of preparing a mixed composition by mixing the first plant extract comprising three hundred s. Extract with the rice bran extract and after mixing the ginseng extract to the mixed composition after the first plant extract mixing step to prepare a mixed composition It may be to include a second plant extract mixing step.

In the method for producing a fertility-improving composition, the first plant extract may further include a barberry extract.

Composition for improving fertility according to the present invention by using a component derived from natural products to allow the irregular menstrual cycle and ovulation can be wired to improve the menstrual irregularity and irregular ovulation cycle.

The fertility-improving composition has little problem of side effects by using components derived from natural products, and thus can be taken for a long time, and thus may have a great effect in improving menstrual irregularities and irregular ovulation cycles.

When the production method of the fertility improvement composition according to the present invention may provide the composition for fertility improvement.

Hereinafter, embodiments of the present invention will be described in detail so that those skilled in the art can easily practice the present invention. As those skilled in the art would realize, the described embodiments may be modified in various different ways, all without departing from the spirit or scope of the present invention.

Preparation Example 1: Preparation of Rice Bran Extract

After grinding the rice bran was mixed with hot water and extracted with hot water for 5 hours. Thereafter, the mixture was cooled to 15 to 30 ° C., and then filtered using a filter paper to prepare Rice Bran Extract 1. In addition, the rice bran extract 1 was inoculated with Aspergillus duckwood (Aspergillus oryzae) and fermented for 2 days while maintaining 30 to 40 ℃ and filtered with a filter paper to prepare a rice bran extract 2. In addition, rice bran extract 4 was inoculated using Bacillus licheniformis (Bacillus licheniformis) by inoculation of rice bran extract 3 and Pichia farinosa.

In addition, the prepared rice bran extract 1 to 4 were mixed by adding inositol, coenzyme cutene, selenium, and vitamin C according to the composition shown in Table 1 below.

A1 A2 A3 A4 A5 Rice bran extract 1 - 100 - - - Rice bran extract 2 - - 100 - - Rice bran extract 3 - - - 100 - Rice bran extract 4 - - - - 100 Inositol 5 5 5 5 5 Coenzyme Kyuten 5 5 5 5 5 Selenium 3 3 3 3 3 Vitamin C 3 3 3 3 3

(Unit: parts by weight)

Experimental Example 1: Ovulation cycle improvement effect experiment

Health functional foods for women in their 20s and 30s of childbearing age who had menstrual irregularities or irregular menstrual cycles and who were taking A11-type health functional foods for 6 months or longer. Change (A1) to A2 to A5 and take it twice a day for 6 months in the same way as A1, and then evaluate the improvement of menstrual pain and menstrual cycle improvement compared to the A1 that was previously taken. In addition, the ovulation tester was used to check whether the ovulation cycle was improved. In addition, for the direct comparison, the effect of A1 was set to 5, and A2 to A5 were evaluated with an index of 1 to 10. The results are shown in the following [Table 2]. The higher the number, the better the improvement effect.

A1 A2 A3 A4 A5 Improving menstrual pain 5 5.3 5.6 7.5 6 Menstrual cycle improvement 5 6.2 5.1 8.1 6 Improved Ovulation Cycle 5 5.8 5.5 7.8 6.2

(Unit: index) Referring to the above [Table 2], it can be seen that the effect of improving menstrual pain and menstrual cycle is improved compared to A1 in the case of A2 to A5. It can be seen that it is improved to have regularity. Therefore, when using a mixture of rice bran extract in inositol, coenzyme cuene, selenium, and vitamin C, the synergistic effect of the interaction is improved compared to the case of using only inositol, coenza cuene, selenium, vitamin C, and menstrual pain and menstrual cycle, In particular, it can be seen that the fertility of women is improved by improving the ovulation cycle.

In particular, in the case of A4 it was confirmed that the menstrual cycle and ovulation cycle significantly increased.

Preparation Example 2: Preparation of Mixed Extract

In addition to the composition of A4, in order to confirm the synergistic effect of the mixed use of natural extracts, each of the natural products was prepared by using hot water to extract the heat extract based on 100 parts by weight of rice bran extract in a predetermined range as shown in Table 3 below. A mixed extract was prepared in A4 of the preparation example.

M1 M2 M3 M4 Triticale extract 5 5 5 5 Barberry Extract - - One One Ginseng extract - 10 10 10 Jade extract - - - 5

(Unit: parts by weight)

Experimental Example 2: Ovulation cycle improvement effect experiment of the mixed extract]

The M1 to M2 were tested in the same manner as in Experimental Example 1 to confirm the synergistic effect of the use of the mixed composition of the respective extracts, the results are shown in the following [Table 4].

A1 A4 M1 M2 M3 M4 Improving menstrual pain 5 7.5 8.2 8.4 8.5 8.5 Menstrual cycle improvement 5 8.1 7.9 8 8.3 8.6 Improved Ovulation Cycle 5 7.8 7.6 8.1 8.6 8.9

(Unit: index) Referring to the above [Table 4], when compared with A4, it can be seen that the effect of improving menstrual pain in the case of M1 to M4. Therefore, the improvement of menstrual pain can be confirmed by the use of the mixed extract.

On the other hand, M1 and M2 could not confirm the remarkable improvement on the menstrual cycle and ovulation cycle improvement effect compared to A4, but M3 and M4 was able to confirm the additional improvement of menstrual cycle and ovulation cycle compared to A4. . Therefore, M3 and M4 can be confirmed that fertility can be improved by improving the ovulation cycle by increasing the activity of the active ingredient by interaction.

Although the preferred embodiments of the present invention have been described in detail above, the scope of the present invention is not limited thereto, and various modifications and improvements of those skilled in the art using the basic concepts of the present invention defined in the following claims are also provided. It belongs to the scope of rights.

Claims (7)

Rice bran extract;
Inositol;
Coenzyme qtene;
Selenium and
That contains vitamin C
Composition for improving fertility. The method of claim 1,
It further comprises a first plant extract comprising the three hundred seconds extract
Composition for improving fertility. The method of claim 2,
Further comprising a second plant extract containing ginseng extract
Composition for improving fertility. The method of claim 3, wherein
The rice bran extract is
Fermented by inoculation of rice bran powder and hot water mixture with any one selected from the group consisting of Aspergillus oryzae, Bacillus licheniformis, Pichia farinosa, and mixtures thereof. That
Composition for improving fertility. Food comprising a composition for improving fertility according to any one of claims 1 to 4. Rice bran powder, prepared by grinding rice bran, is mixed with hot water and selected from the group consisting of Aspergillus oryzae, Bacillus licheniformis, Pichia farinosa, and mixtures thereof. Inoculating and fermenting any one to prepare rice bran extract;
A first plant extract mixing step of preparing a mixed composition by mixing the first plant extract including the tritical herb extract to the rice bran extract;
After the first plant extract mixing step comprising the second plant extract mixing step of preparing a mixture composition by mixing ginseng extract in the mixture composition
Method for producing a fertility improvement composition. The method of claim 6,
The first plant extract is
It further comprises a barberry extract
Method for producing a fertility improvement composition.