KR20190108733A - Fat composition comprising human milk fat substitute and cosmetic composition comprising the same - Google Patents

Abstract

The present invention relates to a fat or oil composition containing breast milk fat substitute and a cosmetic composition comprising the same and, more specifically, to a fat or oil composition which is obtained by enzymatically transesterifying a fat and oil mixture containing palm fractionated oil and sunflower oil in a specific content ratio, and contains the breast milk fat substitute which are high in 1,3-dioleoyl-2-palmitoyl glyceride (OPO) content, thereby showing an excellent moisturizing effect when applied to the skin, and to a cosmetic composition comprising the same.

Description

Fat composition comprising human milk fat substitute and cosmetic composition comprising the same

The present invention relates to a fat or oil composition containing mother's milk fat substitutes and a cosmetic composition comprising the same, and more particularly, to obtain an oil-fat mixture comprising palm fraction oil and sunflower oil in a specific content ratio by enzymatically transesterification. The present invention relates to an oil-fat composition and a cosmetic composition comprising the same, by containing a substitute for breast milk fat having a high content of 1,3-dioleoyl-2-palmitoyl glyceride (OPO).

Triacylglycerides fats and oils are very widely used in the cosmetic industry, among which 1,3-dioleoyl-2-palmitoyl glyceride (OPO) is used for breast milk. Many important researches have been conducted on the application of these compounds.

Oil or fat compositions containing the major fatty acids that make up the mother's milk fat are found a lot in oils and fats of vegetable origin, but almost all plant-derived glycerides do not have saturated fatty acids in the 2-position. In contrast, palmitic acid, a significant amount of saturated fatty acids in breast milk, occupies the 2-position of glycerides.

The skin tissue is largely divided into three layers: epidermal layer, dermis layer and subcutaneous fat. The epidermal layer is divided into the stratum corneum, granule layer, polar layer, and basal layer in order from the outside. And remain soft, which is largely dependent on the moisture present in the stratum corneum.

The moisture content of the stratum corneum is determined by the amount of sebum in the epidermis and the natural moisturizing factor (NMF), an aqueous component present in the stratum corneum. Among them, sebum covers the skin surface to prevent trans-epidermal water loss, whereas NMF is hygroscopic in itself and lowers the tension of the skin surface to reduce the repulsive force of keratinocytes. By preventing the effect directly on the skin moisturizing power.

Conventionally, polyhydric alcohols such as glycerin, propylene, sorbitol, and the like have been most often used as humectants. For example, Korean Patent Laid-Open Publication No. 10-2004-0021695 discloses a moisturizer including an ester compound of glycerin and linear saturated fatty acid, a divalent water soluble alcohol, and a trivalent or higher water soluble polyhydric alcohol. In addition, Korean Unexamined Patent Publication No. 10-2014-0117862 discloses an oil-in-water type silicone emulsion moisturizing cosmetic composition containing a high concentration of a polyol moisturizing component and a water-soluble moisturizing component. However, if the chemical synthesis raw materials are used a lot, it may adversely affect the skin due to skin dryness, irritation, allergy, etc.

Korean Patent Publication No. 10-1732977 discloses a composition similar to breast milk fat, including 24-34% by weight of enzyme-ester-exchanged palm oil, 6-19% by weight of coconut oil, 9-17% by weight of sunflower oil and soybean oil as a balance. The plant fat composition of is disclosed. However, the fat composition disclosed in this patent not only has insufficient skin initial moisturizing effect, but also has a problem of low skin moisturizing retention after application.

It is an object of the present invention to provide an oil-fat composition and a cosmetic composition comprising the same, which are particularly suitable for cosmetics, using components derived from nature so that consumers can use them with confidence.

According to an aspect of the present invention, a raw material oil-fat mixture comprising palm fractionation oil and sunflower oil comprises a fat or oil component obtained by enzymatically transesterifying the raw material fat-and-oil mixture with 10 to 49 wt% palm fraction oil and sunflower A fat or oil composition is provided, comprising 51 to 90 weight percent oil.

According to another aspect of the present invention, there is provided a cosmetic composition comprising the fat or oil composition of the present invention.

Since the oil-fat composition and the cosmetic composition including the same according to the present invention are manufactured using ingredients derived from nature, consumers can use it with confidence, and the content of 1,3-dioleoyl-2-palmitoyl glyceride (OPO) is high. Moisturizing effect is very good.

Hereinafter, the present invention will be described in detail.

The oil-fat composition of this invention contains the oil-fat component obtained by enzymatically transesterifying the raw material fat-oil mixture containing palm fractionation oil and sunflower oil.

The palm fractionation oil is a fat or oil obtained by fractionating palm oil, which is a vegetable oil, and the iodine value thereof may be, for example, 10 to 30, and more specifically, 14 to 20, but is not limited thereto.

The oleic acid content of the sunflower oil may be, for example, 70% by weight or more (eg, 70 to 90% by weight), and more specifically 75% by weight or more (eg, 75 to 85% by weight), but is not limited thereto. Does not.

The raw material fat-and-oil mixture used for manufacture of the fats and oils composition of this invention contains 10-49 weight% of palm fractionation oils, and 51-90 weight% of sunflower oils. If the content ratio of palm fraction oil and sunflower oil in the raw fat mixture is out of the above level, the moisturizing effect of the resulting fat or oil composition may worsen.

More specifically, the raw material oil and fat mixture may include 15 to 47% by weight palm fractionation oil and 53 to 85% by weight sunflower oil.

Even more specifically, the raw material oil and fat mixture may include 20 to 45% by weight palm fractionation oil and 55 to 80% by weight sunflower oil.

Even more specifically, the raw material oil and fat mixture may include 25 to 40% by weight palm fractionation oil and 60 to 75% by weight sunflower oil.

Even more specifically, the raw material oil and fat mixture may include 30 to 35% by weight palm fractionation oil and 65 to 70% by weight sunflower oil.

In the present invention, the reaction temperature of the enzymatic transesterification reaction may be determined according to the type of enzyme used, and specifically, may be 40 ° C. or higher, 45 ° C. or higher, 50 ° C. or higher, 55 ° C. or higher, or 60 ° C. or higher, In addition, the temperature may be 85 ° C. or less, 80 ° C. or less, 75 ° C. or less, 70 ° C. or less, or 65 ° C. or less, but is not limited thereto. In one embodiment, the reaction temperature of the enzymatic transesterification reaction may be 55 ° C to 75 ° C.

As the enzyme of the enzymatic transesterification reaction in the present invention, known enzymes can be used. Specifically, Rhizomucor miehei, Candida Antarctica B, Thermomyces lanuginose, Rhizomucour miehei, Rhizopus delemar ), Mucomiemie, Alcaligenes sp., Aspergillus niger, Candida cylindraces, Burkholderia cepacia, Geodum candidum ) And combinations thereof may be used, but not limited to, esterification enzymes derived from microorganisms.

According to a preferred embodiment of the present invention, esterification enzymes derived from Rhizomucor miehei are used as enzymes of enzymatic transesterification reactions.

In one embodiment of the present invention, the amount of the enzyme may be, for example, 5 parts by weight, 10 parts by weight or 15 parts by weight or more, and 40 parts by weight or less, based on 100 parts by weight of the total mixture before the reaction. It may be up to 30 parts by weight or up to 25 parts by weight. If the amount of the enzyme is too small compared to the total amount of the pre-reaction mixture, there may be a problem that the efficiency does not occur because the reaction does not occur, on the contrary, if the amount of the enzyme is too high, the reaction proceeds rapidly and the reaction cannot be controlled. There may be a problem that the enzyme activity falls sharply.

In another embodiment of the present invention, when the enzymatic transesterification reaction is carried out continuously, the reaction flow rate may be, for example, 0.2 to 2.0, more specifically 0.2 to 1.5, and even more specific. As may be 0.2 to 1.0, it is not necessarily limited thereto.

According to the present invention, 50 to 80 parts by weight of 100 parts by weight of the fatty acid residue at the sn-2 position are palmitic acid residues; C52 (neutral lipid having a total number of carbon of 52) of 40 parts by weight to 100 parts by weight of total triglycerides; The ratio of oleic acid is 40 to 80 parts by weight and the ratio of palmitic acid is 20 to 50 parts by weight in 100 parts by weight of the total fatty acid residues in the composition; A fat or oil composition is provided.

More specifically, in the fat or oil composition, 50 to 70 parts by weight, 50 to 60 parts by weight, 52 to 60 parts by weight, or 52 to 58 parts by weight of 100 parts by weight of the fatty acid residue in the sn-2 position may be palmitic acid residues. Can be.

The fat or oil composition according to the present invention is prepared from vegetable oils of natural origin, and covers the skin surface to prevent trans-epidermal water loss, thereby preventing skin drying, preventing skin aging, and promoting skin Excellent moisturizing function to control the amount of water retained.

Therefore, according to another aspect of the present invention, there is provided a cosmetic composition, preferably a skin moisturizing cosmetic composition comprising the fat or oil composition of the present invention.

In one embodiment, the cosmetic composition of the present invention, preferably the skin moisturizing cosmetic composition is a lotion, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, powder, body lotion It may have any one formulation selected from the group consisting of, but is not limited thereto.

The oil-fat composition content of the present invention included in the cosmetic composition of the present invention, preferably the skin moisturizing cosmetic composition may be, for example, 1 to 20% by weight, based on the total weight of the cosmetic composition, but is not limited thereto.

The cosmetic composition, preferably the skin moisturizing cosmetic composition, according to the present invention has excellent moisturizing retention after application, for example, the moisturizing increase rate may be 0.1 to 20% after 4 hours of application. More specifically, the moisturizing increase rate after 4 hours of application of the cosmetic composition according to the present invention may be at least 0.5%, at least 1%, at least 2%, at least 3%, at least 4%, or at least 5%, and at most 19%, 17% or less, 15% or less, 12% or less, 10% or less, or 8% or less, but is not limited thereto.

In addition to the fat or oil composition of the present invention, the cosmetic composition provided according to the present invention may further include ingredients or raw materials commonly used in the cosmetic composition according to the specific purpose.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, these examples are only for illustrating the present invention, and the scope of the present invention is not limited by these examples.

[ Example ]

Oils and fats composition

In the presence of an enzyme derived from Rhizomucor miehei, based on 100 parts by weight of the raw fat mixture containing 33 parts by weight of palm fractionated oil (iod number: 17) and 67 parts by weight of sunflower oil (oleic acid content: 80% by weight). An enzymatic transesterification reaction was carried out to prepare an oil-fat composition for cosmetic preparation according to the present invention.

As a result of gas chromatography analysis of the prepared oil-fat composition, the C52 content of the oil-fat composition was 42.5 weight%, and the palmitic acid content in the fatty acid composition of the sn-2 position was 55 weight%.

Cream manufacturers

In the composition as shown in Table 1 below, 100 parts by weight of base cream was added to each additional composition to prepare a test cream.

In Table 1 below, the OPO oils of # 2 and # 3 are the oil-fat compositions prepared above as examples of the present invention.

In Table 1, CEH of # 1 is cetyl ethylhexanoate as a comparative example, palm olein oil of # 4 fractionated palm oil as a comparative example (iodine number: 54 to 58, 52 carbons) Neutral lipid (C52) having a number: 45.8% by weight, palmitic acid content in the sn-2 fatty acid composition: 20.5% by weight), and the mixed oil of # 5 was prepared according to Korean Patent No. 10-1732977. Examples are plant fat compositions comprising 40% soybean oil, 30% palm oil, 10% palm oil and 20% high oil sunflower, all of which are commonly used in base cream formulations.

The base cream composition is as follows.

EDTA-2Na: ethylenediaminetetraacetic acid disodium salt dihydrate

DPG-K2: Glycyrizinate Dipotassium Salt (Dipotassium Glycyrrhizinate)

Moisturizer: Liponic EG1

Preservative: Dub Diol

Thickener: 2% TR-1

[ Test Example ]

1. Hardness Analysis

The prepared cream was filled in a circular container (diameter 5 cm, height 3 cm) of a constant size and the hardness was measured using a Fudoh Rheo Meter (Rheotech, Japan). The pressure in the center of the container containing the cream was measured by pressing the probe, and the pressure was measured. Between each measurement, the probe was washed with distilled water and dried with a soft tissue. The test results are shown in Table 2 below.

2. DermaLab  Moisture improvement evaluation by USB moisture probe

In order to equalize the skin condition of the test subjects before the instrument measurement, the forearm region, which is the test site, was washed, stabilized for 30 minutes, and then instrument measurement was performed. Test substances (creams of # 1 to # 5) were applied to the left forearm of the subject in the form of a 2.0 cm × 2.0 cm square 50 μg each, absorbed using Latex finger cot, and then measured. Was carried out.

DermaLab USB moisture probe (Cortex Technology, Inc., Denmark) was used to analyze changes in skin moisture content. The probe in contact with the skin measures the moisture content of the top layer of the skin indirectly by electrical conductivity. The higher the moisture content of the skin, the higher the measurement value, and the unit of measurement is micro Siemens (cm) / cm. After each measurement, the sensor was wiped with a soft cloth and measured. The left forearm of the subject was measured five times, and the average was calculated. Instrument measurements were made before and after 30 minutes of application of the test substance and at 2, 4 and 6 hours of application. Table 3 shows the results of measuring the skin moisturizing amount of the test substances.

Moisturizing amount initial 30 minutes increase (%) = [measured value-pre-measured value 30 minutes after application] / [measured value before application] × 100

Moisture increase rate (%) after 4 hours of application = [measured value-pre-measured value after 4 hours of application] / [measured value before application] * 100

As a result of the test, in the # 2 and # 3 containing the OPO fats and oils of the present invention, the moisturizing amount was maintained up to 6 hours after application, and the higher the OPO fat content, the higher the moisturizing amount. On the other hand, in the case of # 4 and # 5, the amount of moisturizing tended to drop sharply with time after application, and the moisturizing effect of # 1 without neutral lipid was also poor.

3. DermaLab  USB TEWL  by probe Transdermal moisture loss  Improvement evaluation

In this study, transdermal moisture loss was analyzed using DermaLab USB TEWL probe (Cortex Technology, Inc.) to evaluate the improvement of dermal transdermal moisture loss. Percutaneous moisture loss was measured three times in a row while keeping the probe vertically in contact with the left forearm of the subject. The analysis used an average of three measurements and the higher the value, the greater the loss of moisture. Instrument measurements were made at the time points before application of test substance and after 30 minutes of application, at 2 hours, 4 hours and 6 hours after application. The results of measuring the transdermal moisture loss of the test substances are shown in Table 4 below.

Loss amount initial change rate (%) = [measurement value after application-pre-measurement measured value] / [measurement before application] * 100

As a result of this test, in the # 2 and # 3 containing the OPO fats and oils of this invention, the water loss amount was maintained at the outstanding low level even after 6 hours of application | coating, and the initial water loss amount also drastically reduced. On the other hand, in the case of # 4 and # 5, the loss tended to increase rapidly with time after application.

Claims (9)

A fat and oil component obtained by enzymatically transesterifying a raw fat and oil mixture comprising palm fractionated oil and sunflower oil, wherein the raw fat and oil mixture comprises 10 to 49% by weight palm oil and 51 to 90% by weight sunflower oil. Fat and oil composition The fat or oil composition according to claim 1, wherein the iodine value of palm fractionated oil is 10 to 30. The fat or oil composition according to claim 1, wherein the oleic acid content of sunflower oil is at least 70% by weight. The fat or oil composition according to claim 1, wherein the enzyme of the enzymatic transesterification reaction is an esterification enzyme derived from Rizomucor miehei. 50 to 80 parts by weight of 100 parts by weight of the fatty acid residue at the sn-2 position is a palmitic acid residue; C52 (neutral lipid having a total number of carbon of 52) of 40 parts by weight to 100 parts by weight of total triglycerides; The ratio of oleic acid is 40 to 80 parts by weight and the ratio of palmitic acid is 20 to 50 parts by weight in 100 parts by weight of the total fatty acid residues in the composition; Fats and oils composition. Cosmetic composition containing the fats and oils composition of any one of Claims 1-5. The cosmetic composition according to claim 6, wherein the cosmetic composition is for skin moisturizing. According to claim 6, wherein the cosmetic composition is any one selected from the group consisting of lotion, nutrition cream, massage cream, essence, eye cream, eye essence, cleansing cream, cleansing foam, cleansing water, pack, powder, body lotion Cosmetic composition for moisturizing the skin having a formulation. The cosmetic composition according to claim 7, wherein the moisturizing increase rate is 4 to 20% after 4 hours of application.