JP6758877B2 - O / W type emulsified composition - Google Patents

Description

The present invention relates to an O / W type (oil-in-water type) emulsified composition. More specifically, the present invention relates to an O / W type emulsified composition having an excellent feel on the skin and a feel when applied.

Ceramide is an intercellular lipid present in the epidermis (corneal layer) of human skin. It is known that the amount of ceramide in the stratum corneum decreases with aging, etc., and as a result, the skin becomes dry and wrinkles occur, and the deterioration of the barrier function causes the invasion of allergens, etc., causing inflammation and itching. It will occur. It is effective to apply ceramide externally for such a symptom, but when ceramide is added to the external composition, there are problems such as poor usability at the time of application, stickiness, and poor skin compatibility. In addition, in areas where dryness and fine wrinkles are likely to occur, such as between the eyebrows, around the eyes, and nasolabial folds, the feel (feeling of application) that is felt when the external composition is placed on the skin and spread with fingers is important, and the feeling of application is important. Specifically, it is necessary to give a feeling of resistance (a feeling of retaining the shape of the emulsified composition) at the beginning and a feeling of gradually becoming familiar with the skin (this is also referred to as "thickness" in the present specification). Is desirable.

As a method for improving the usability of such an external composition containing ceramide, a technique for improving the usability without stickiness by containing ceramide and a phosphoric acid triester having a specific structure (Patent Document 1) and the like. Has been proposed, but it is still not sufficient and there is room for improvement.

Further, although Patent Document 2 describes a technique for imparting a "richness" to an emulsified composition as a feeling similar to the "thickness", it imparts a "richness" to an external composition containing ceramide. The method is not described.

Japanese Unexamined Patent Publication No. 9-67224 Japanese Unexamined Patent Publication No. 2011-21007

An object of the present invention is to provide an O / W type emulsified composition having an excellent feeling of use and / or application to the skin, specifically, an O / W type emulsified composition which is not sticky at the time of use and is familiar to the skin. That is. Another object of the present invention is to provide an O / W type emulsified composition having a unique feeling of application (thickness) that is felt when it is placed on the skin and spread out, separately from the above-mentioned feeling of use or in addition to the above-mentioned feeling of use. It is to be.

The present inventors have been diligently studying to solve the above problems, and as shown in the experimental examples described later, (A) ceramides, (B) nonionic surfactants, (C) shea butter, And (D) water are combined to prepare an O / W type emulsified composition, whereby an external composition having an excellent usability and an external composition having a coating feeling in addition to the above usability can be obtained. The present invention has been completed. Further, the above-mentioned effect of the O / W type emulsified composition is that (E) an anionic thickener, (F) hydrocarbon, and / or (G) many are added to the components (A) to (D). It was confirmed that it was further enhanced by adding a hydrocarbon.

The present invention has been completed based on these findings, and has the following embodiments.

(I) O / W type emulsified composition (I-1) An O / W type emulsified composition containing the following components:
(A) Ceramides,
(B) Nonionic surfactant,
(C) shea butter and (D) water.
(I-2) The O / W type emulsified composition according to (I-1), which further contains (E) an anionic thickener.
(I-3) The O / W type emulsified composition according to (I-1) or (I-2), which further contains (F) a hydrocarbon.
(I-4) The O / W type emulsified composition according to any one of (I-1) to (I-3), which further contains (G) a polyhydric alcohol.
(I-5) contains 0.1 to 3% by weight of (A), 4 to 8% by weight of (B), and 0.5 to 2% by weight of (C) (I-1) to. The O / W type emulsified composition according to any one of (I-4).
(I-6) The O / W type emulsified composition according to any one of (I-1) to (I-5), which is an external preparation for skin.

(II) Usability improving method / coating feeling improving method (II-1) (A) Usability improving method or / and coating feeling improving method of O / W type emulsified composition containing ceramides, (A) ) A method characterized by blending (B) a nonionic surfactant, (C) shea butter, and (D) water in addition to ceramides to prepare an O / W type emulsified state.
(II-2) The method according to (II-1), wherein (E) an anionic thickener is further added to the O / W type emulsified composition.
(II-3) The method according to (II-1) or (II-2), which further comprises adding (F) a hydrocarbon to the O / W type emulsified composition.
(II-4) The method according to any one of (II-1) to (II-3), which further comprises adding (G) a polyhydric alcohol to the O / W type emulsified composition.
(II-5) (A) is blended in an amount of 0.1 to 3% by weight, (B) is blended in a proportion of 4 to 8% by weight, and (C) is blended in a proportion of 0.5 to 2% by weight (II-1) to. The method according to any one of (II-4). (II-6) The method according to any one of (II-1) to (II-5), wherein the O / W type emulsified composition is an external preparation for skin.

Although the O / W type emulsified composition of the present invention contains ceramides as an active ingredient, the sticky feeling is significantly suppressed, the skin fits well, and the feeling of use on the skin is excellent. Further, the O / W type emulsified composition of the present invention has a unique application feeling (thickness feeling) when it is placed on the skin and spread out in addition to the above-mentioned feeling of use or separately from the above-mentioned feeling of use. .. That is, according to the present invention, it is possible to provide an emulsified composition having an excellent feeling of use and / or feeling of application (thickness) on the skin.

(I) O / W type emulsified composition The emulsified type pharmaceutical composition of the present invention has an emulsified form and is characterized by containing at least the following components:
(A) Ceramides,
(B) Nonionic surfactant,
(C) shea butter and (D) water.

Hereinafter, each of these components will be described.
(A) Ceramides The ceramides targeted by the present invention include ceramides (natural ceramides, human ceramides, vegetable ceramides, etc.) and ceramide analogs (pseudo-ceramides, etc.).

Here, ceramide is a kind of sphingolipid, and is a general term for a group of compounds in which a long-chain fatty acid is amide-bonded to an amino group of sphingosine. It is subdivided into 11 types (ceramides 1 to 11) depending on the structure of sphingosine (N-acyl group structure, etc.) and the structure of long-chain fatty acids (for example, Robson KJ, Stewart ME, Michelsen S, Lazo ND, Downing DT .: 6-Hydroxy-4-sphingenine in human epidermal ceramides. J Lipid Res. 1994 Nov; 35 (11): 2060-8; and Kenya Ishida et al. Development and application of natural ceramide Optically active ceramide preparation focusing on intercellular lipids in the stratum corneum ”” FRAGRANCE JOURNAL 2004-11: 23-32).

In the present invention, any ceramide having the above-mentioned ceramide structure can be used, and in addition to animal or plant-derived ceramides, ceramides obtained by organic synthesis may be used. Further, asymmetric carbon is present in these, and an optically active substance and a racemic form (optically inactive substance) are present, and any of them can be used in the present invention. An optically active substance is preferable. Of these, ceramide 1, ceramide 2, and ceramide 3 are preferable. Commercially available ceramides include, for example, ceramide 1 (trade name; CERAMIDE I (manufactured by Ebonic Japan Co., Ltd.)), ceramide 2 (trade name: CERAMIDE TIC-001 (manufactured by Takasago Fragrance Industry Co., Ltd.)) ceramide 3. (Product name: CERAMIDE III (manufactured by Ebonic Japan Co., Ltd.)) and the like.

Ceramide analogs include pseudo-ceramides that are similar in structure and properties to ceramides, and extracts and derivatives (sphingosine derivatives) from their components. Examples of the ceramide analog include JP-A-62-228048, JP-A-63-216812, JP-A-63-227513, JP-A-64-29347, and JP-A-64-31752. Includes ceramide-like structural substances described in JP-A-8-319263 and the like. Specifically, a compound selected from the compound represented by the following general formula (1) and the compound represented by the general formula (2) can be mentioned.

［式中、Ｒ^１ｂは炭素数１０〜２６の炭化水素基、Ｒ^２ｂは炭素数９〜２５の炭化水素基を示し、Ｘは−（ＣＨ_２）_ｎ−を示す。なお、ｎは２〜６の整数を示す。］

[In the formula, R ^1b represents a hydrocarbon group having 10 to 26 carbon atoms, R ^2b represents a hydrocarbon group having 9 to 25 carbon atoms, and X represents − (CH ₂ ) _n −. Note that n represents an integer of 2 to 6. ]

［式中、Ｒ^１及びＲ^２は同一または異なって炭素数１〜４０のヒドロキシル化されていてもよい炭化水素基を示し、Ｒ^３は炭素数１〜６のアルキレン基又は単結合を示し、Ｒ^４は水素原子、炭素数１〜１２のアルコキシ基又は２，３−ジヒドロキシプロピルオキシ基を示す。但し、Ｒ^３が単結合であるときはＲ^４は水素原子である。］

[In the formula, R ¹ and R ² represent the same or different hydroxyl groups having 1 to 40 carbon atoms, and R ³ represents an alkylene group having 1 to 6 carbon atoms or a single bond. R ⁴ represents a hydrogen atom, an alkoxy group or a 2,3-dihydroxypropyl group having 1 to 12 carbon atoms. However, when R ³ is a single bond, R ⁴ is a hydrogen atom. ]

In the above formulas (1) and (2), an alkyl group or an alkenyl group can be preferably mentioned as the hydrocarbon group.

One type of ceramide may be used alone, or two or more types may be used in any combination. Preferred ceramides are human-type (optically active) ceramides, and as described above, at least one selected from the group consisting of ceramide 1, ceramide 2, and ceramide 3 can be mentioned. It is preferable to use two or more of these three types of ceramides, preferably a combination of three types. For example, when three types are used in combination, when ceramide 2 is 100 parts by weight, ceramide 1 is 0.002 to 300 parts by weight and ceramide 3 is 0.24 to 300 parts by weight. can do. Preferably, the ratio of ceramide 1 is 0.00495 to 100 parts by weight and that of ceramide 3 is 1.25 to 149.5 parts by weight.

The proportion of ceramides contained in the O / W type emulsified composition of the present invention at least supplements the barrier function and moisturizing function of the stratum corneum of the epidermis and impairs the effect (feeling of use and / or feeling of application) of the present invention. The amount may be absent, and is not particularly limited as long as it is not. Usually, it can be appropriately selected in the range of 0.1 to 3% by weight per 100% by weight of the O / W type emulsified composition of the present invention. It is preferably 0.2 to 3% by weight, more preferably 0.5 to 3% by weight.

(B) Nonionic Surfactant The nonionic surfactant targeted by the present invention includes ether-type, ester-ether-type, and ester-type nonionic surfactants.
Here, as the ether type nonionic surfactant, for example, polyoxyethylene (POE) alkyl ether (AE) obtained by addition polymerization of ethylene oxide (EO) to a higher alcohol having 10 to 18 carbon atoms; EO to alkylphenol. Polyoxyethylene (POE) alkylallyl ether obtained by addition polymerization of, and polyoxyethylene polyoxypropylene glycol obtained by addition polymerization of ethylene oxide (EO) to polypropylene glycol and the like can be raised. Examples of the ester-ether type nonionic surfactant include a compound obtained by adding EO to a fatty acid ester of a polyhydric alcohol, specifically, a polyoxyethylene sorbitan fatty acid ester and the like. Further, examples of the ester-type nonionic surfactant include higher alcohol fatty acid esters such as polyglycerin, glycerin, sorbitan, sugar and propylene glycol. These may be used individually by 1 type, or may be used in any combination of 2 or more type.

Among them, the ester-type nonionic surfactant is a surfactant that can be suitably used in order to exert the effects (feeling of use and / or feeling of application) of the present invention. Specific examples of the ester-type nonionic surfactant include, but are not limited to, polyglycerin fatty acid ester, glycerin fatty acid ester, sorbitan fatty acid ester, and sucrose fatty acid ester.

Examples of the fatty acid constituting these ester-type nonionic surfactants include, but are not limited to, saturated or unsaturated fatty acids having 8 to 24 carbon atoms. Saturated fatty acids with 8 to 24 carbon atoms include caprylic acid (8: 0), pentadecanoic acid (9: 0), capric acid (10: 0), lauric acid (12: 0), and myristic acid (14: 0). , Pentadecanoic acid (15: 0), palmitic acid (16: 0), margaric acid (17: 0), stearic acid (18: 0), arachidic acid (20: 0), behenic acid (22: 0), and Lignoceric acid (24: 0) can be mentioned. Unsaturated fatty acids with 8 to 24 carbon atoms include palmitoreic acid (16: 1), oleic acid (18: 1 (9)), baxenoic acid (18: 1 (11)), and nervonic acid (24: 1). Unsaturated fatty acids with one double bond such as; two double bonds such as linoleic acid (18: 2 (9,12)) and 8,11-eikosazienoic acid (20: 2 (8,11)) Unsaturated fatty acids with; (9,12,15) -linolenic acid (18: 3), (6,9,12) -linolenic acid (18: 3), and eleostearic acid (18: 3 (9,11) , 13)), and unsaturated fatty acids having three double bonds such as 5,8,11-eikosatrienic acid (20: 3 (5,8,11)), preferably 10 carbon atoms. It is a saturated fatty acid of ~ 18, more preferably a saturated fatty acid having 12-18 carbon atoms.

Among the ester-type nonionic surfactants, polyglycerin fatty acid ester and glycerin fatty acid ester are preferable.

Here, examples of the polyglycerin fatty acid ester include an ester composed of polyglycerin in which 2 to 10 glycerins are condensed and a saturated or unsaturated fatty acid having 8 to 24 carbon atoms. More preferably, it is an ester composed of polyglycerin in which 4 to 10 glycerins are condensed and saturated fatty acid having 12 to 18 carbon atoms. The glycerin fatty acid ester is preferably an ester composed of saturated or unsaturated fatty acids having 8 to 24 carbon atoms, and more preferably an ester composed of saturated fatty acids having 12 to 18 carbon atoms.

Among these polyglycerin fatty acid esters, specific examples thereof include polyglyceryl laurate-6, polyglyceryl myristate-6, polyglyceryl stearate-6, polyglyceryl laurate-10, polyglyceryl myristate-10, and polyglyceryl stearate-10. Among the glycerin fatty acid esters, specific examples thereof include glyceryl myristate, glyceryl stearate, and glyceryl oleate.

The ratio of the nonionic surfactant contained in the O / W type emulsified composition of the present invention is not particularly limited as long as it is an amount that exerts the effect of the present invention. Usually, it can be appropriately selected in the range of 4 to 8% by weight per 100% by weight of the O / W type emulsified composition. Preferably, 5 to 8% by weight, more preferably 5.5 to 8% by weight can be exemplified.

(C) Shea butter Shea butter is a vegetable fat mainly composed of stearic acid and oleic acid, which is obtained from the embryo of the seed of Vitellaria obovata of the family Sapotaceae, and is also called shea butter. Will be done.

The ratio of the shea fat contained in the O / W type emulsified composition of the present invention is not particularly limited as long as it is an amount that exerts the effect of the present invention. Usually, it can be appropriately selected in the range of 0.5 to 2% by weight per 100% by weight of the O / W type emulsified composition. Preferably, 0.75 to 2% by weight, more preferably 1 to 2% by weight can be exemplified.

(D) Water Water is not to question, especially the type, for example, purified water, distilled water, ion water, sterile water, and the like deep sea water, it is used without any limitation. Purified water is preferable. The blending ratio of the water in the O / W type emulsified composition of the present invention can be appropriately set from the range of usually 20 to 95.4% by weight. It is preferably 25 to 90% by weight, more preferably 30 to 90% by weight.

The O / W type emulsified composition of the present invention may contain at least the above components (A) to (D), but further includes the following (E) anionic thickener, (F) hydrocarbon, and the like. And (G) at least one selected from the group consisting of polyhydric alcohols can also be blended. These components will be described below.

(E) Anionic Thickener The O / W type emulsified composition of the present invention may further contain (E) anionic thickener in addition to the above-mentioned components (A) to (D). ..

The anionic thickener is not limited, but includes, for example, carboxymethyl cellulose, hyaluronic acid, alginic acid, xanthan gum, carrageenan, arabic rubber, guar gum, carboxyvinyl polymer, acrylic acid / alkyl methacrylate copolymer, sodium polyacrylate and the like. A polymer thickener can be exemplified.

These anionic thickeners may be of natural or synthetic origin and do not particularly limit their origin. Further, it may be one kind alone or a mixture of two or more kinds arbitrarily combined. Preferred are carboxyvinyl polymers, acrylic acid / alkyl methacrylate copolymers, and xanthan gum.

In order to exert the effect of the present invention more effectively, two or more kinds of anionic thickeners can be used in combination. Although not particularly limited, such combinations include a combination of a carboxyvinyl polymer, an acrylic acid / alkyl methacrylate polymer and xanthan gum, a combination of a carboxyvinyl polymer and an acrylic acid / alkyl methacrylate copolymer, and a combination of a carboxyvinyl polymer and xanthan gum. , Acrylic acid / alkyl methacrylate copolymer and xanthan gum are included. A combination of a carboxyvinyl polymer and an acrylic acid / alkyl methacrylate copolymer is preferable.

The blending ratio of the anionic thickener in the O / W type emulsified composition of the present invention (total amount when two or more kinds are used in combination) is usually 0.025 to 1 per 100% by weight of the O / W type emulsified composition. It can be appropriately set from the range of% by weight. It is preferably 0.05 to 1% by weight, more preferably 0.05 to 0.5% by weight.

(F) Hydrocarbon The O / W type emulsified composition of the present invention further contains (F) hydrocarbon in addition to the above-mentioned components (A) to (D) or (A) to (E). May be. As shown in the experimental examples described later, by blending the components (A) to (D), particularly the component (F) in addition to the components (A) to (E), the stickiness during use is improved, and the stickiness is improved. It is possible to prepare an O / W type emulsified composition that gives a feeling of thickness at the time of application.

The hydrocarbon does not impair the effects of the present invention, and may be any component that can be used in an external composition, particularly in the field of cosmetics, for example, and is not particularly limited, but usually has a molecular weight of 200 to 1,000,000. It is preferable that the product is liquid at room temperature (25 ° C.). Examples thereof include hydrocarbon oils such as hydrogenated polyisobutene, α-olefin oligomers, vegetable squalane, squalane, liquid paraffin, pristane, mineral oil, and petrolatum. These can be used individually by 1 type, or can be used in any combination of 2 or more types. Among these hydrocarbons, squalane, vegetable squalane, liquid paraffin, and mineral oil are preferable, and squalane and vegetable squalane are more preferable, because the effects of the present invention can be easily obtained.

The blending ratio of the hydrocarbon in the O / W type emulsified composition of the present invention can be appropriately set from the range of usually 1 to 30% by weight. It is preferably 2.5 to 30% by weight, more preferably 5 to 25% by weight.

(G) Polyhydric Alcohol The O / W type emulsified composition of the present invention is obtained in addition to the above-mentioned components (A) to (D), components (A) to (E), or components (A) to (F). Further, (G) polyhydric alcohol may be contained. As shown in the experimental examples described later, it is used by blending the components (A) to (D), the components (A) to (E), particularly the components (A) to (F) and the component (G). An O / W type emulsified composition having an excellent feeling (non-stickiness, familiarity with the skin) can be prepared.

The polyhydric alcohol does not impair the effects of the present invention, and may be any component that can be used in an external composition, particularly in the field of cosmetics, and is not particularly limited, but has, for example, 2 carbon atoms. A polyhydric alcohol having ~ 6 and 2 to 4 hydroxyl groups can be used. Specifically, for example, ethylene glycol, propylene glycol, 1,3-propanediol (trymethylene glycol), 1,2-butylene glycol, 1,3-butylene glycol, 2,3-butylene glycol, 1,4- Butanediol (tetramethylene glycol), 2-butene-1,4-diol, 1,5-pentanediol (pentamethylene glycol), 1,2-pentanediol, isoprene glycol (isopentyldiol), hexylene glycol, diethylene glycol , And divalent alcohols such as dipropylene glycol, pentylene glycol; trivalent alcohols such as glycerin (including concentrated glycerin), and trimethylolpropane; and diglycerin, pentaerythritol, and 1,2,6-hexanetriol, etc. Diol, etc.

Among these, 1,3-butylene glycol, 1,2-pentanediol, dipropylene glycol, propylene glycol and glycerin are preferable, and 1,3-butylene glycol, 1,2-pentanediol, propylene glycol and glycerin are preferable from the viewpoint of more effectively exerting the effect of the present invention. 3-butylene glycol and glycerin.

The blending ratio of the polyhydric alcohol in the O / W type emulsified composition of the present invention can be appropriately set from the range of 0.1 to 10% by weight per 100% by weight of the O / W type emulsified composition. It is preferably 0.1 to 5% by weight, more preferably 0.1 to 3% by weight.

(H) Other components (optional components) to be blended in the O / W type emulsified composition
In the O / W type emulsified composition of the present invention, other components are appropriately selected according to the form and the like as long as the effects of the present invention are not impaired, and one or two or more thereof are used in combination. Can be mixed. For example, functional components such as a skin absorption promoter (skin penetration promoter), a whitening agent, a moisturizing agent, an anti-inflammatory agent, an anti-wrinkle agent, a blood circulation promoter, and a local anesthetic can be mentioned.
Specific examples include the following.

(H-1) As the skin absorption promoter (skin penetration promoter), those having an action of enhancing the transdermal permeability of ceramides and promoting their absorption into the skin can be used. Such as, for example, fatty acid / fatty acid ester (oleic acid, isopropyl myristate, medium chain fatty acid triglyceride, etc.), biodegradability accelerator (alkyl ester, aminocaproic acid), other amino acids, terpenes, pyrrolidones, urea, etc. Phospholipids and various solvents (polyols, lower alcohols, higher alcohols, dimethylflusulfoxide, etc.) can be exemplified without limitation.

(H-2) Whitening agents include arbutin, vitamin C, vitamin C derivatives, cysteine,
And tranexamic acid and the like can be exemplified without limitation.
Examples of the (H-3) anti-inflammatory agent include loxoprofen sodium, indomethacin, flurbiprofen sodium, chlorpheniramine maleate, glycyrrhetinic acid, dipotassium glycyrrhizinate, and the like without limitation.
(H-4) Examples of the anti-wrinkle agent include hyaluronic acid, collagen, retinol, heparinoids, urea and the like without limitation.
(H-5) As the blood circulation promoter, vitamin E, ginger tincture, sage extract, mugwort extract, placenta and the like can be exemplified without limitation.
(H-6) As the local anesthetic, lidocaine, dibucaine, bupivacaine and the like can be exemplified without limitation.

Further, as optional components that can be blended in the O / W type emulsified composition of the present invention, various additions such as oily components, stabilizers, preservatives, buffers, and pH adjusters generally used in the preparation of emulsified preparations are added. Agents can be mentioned.
(H-7) Examples of the oily component include higher alcohols, vegetable oils, and vegetable sterols (phytosterols, etc.).

Examples of the higher alcohol include aliphatic alcohols having 6 or more carbon atoms, more preferably 6 to 30 carbon atoms. The oily component is preferably solid at room temperature (25 ° C.). Specific examples thereof include cetanol, behenyl alcohol, myristyl alcohol, cetyl alcohol, oleyl alcohol, stearyl alcohol, isostearyl alcohol, hexadecyl alcohol, and lanolin alcohol. These higher alcohols may be used alone or in combination of two or more.

Vegetable oils include macadamia seed oil, jojoba seed oil, canina rose fruit oil, palm oil, avocado oil, olive oil, apricot oil, kukui nut oil, grape seed oil, safflower oil, sweets almond oil, corn germ oil, sunflower oil, and hazelnut. Examples include oil, jojoba wax, rose hip oil and the like. These vegetable oils may be used alone or in combination of two or more.

Plant sterols (phytosterols) are a mixture of sitosterol, which is present in the cell membrane of plants and has a double bond, stigmasterol, campesterol, brassicasterol, fucosterol, and sterol which does not have a double bond. The plant sterols used in the present invention are not particularly limited, and are, for example, grains such as soybeans, rice, wheat and sesame; fruits and vegetables such as radish, cabbage, apples and lettuce; other sunflowers, rapeseed, palms and sesame seeds. Examples include products extracted from the bark of trees and refined products. The type of plant raw material to be extracted is not particularly limited, but preferably plant sterols obtained by separating from scum or the like produced in the deodorizing step of vegetable oil, and sterols obtained as a by-product in the production of pulp. be able to.

(H-8) As an example of the pH adjuster, inorganic acids such as hydrochloric acid, sulfuric acid, phosphoric acid, polyphosphoric acid, boric acid; lactic acid, acetic acid, citric acid, tartaric acid, malic acid, succinic acid, oxalic acid, gluconic acid, Organic acids such as fumaric acid, propionic acid, acetic acid, aspartic acid, epsilon-aminocaproic acid, glutamate, aminoethylsulfonic acid; sodium hydrogen carbonate, sodium carbonate, potassium hydroxide, sodium hydroxide, calcium hydroxide, magnesium hydroxide, etc. Inorganic bases of: monoethanolamine, triethanolamine, diisopropanolamine, triisopropanolamine, organic salts such as lysine and the like.

(H-9) As an example of preservatives, butylparaben, methylparaben, propylparaben,
Ethylparaben, sodium benzoate, phenol, benzyl alcohol and the like can be mentioned.

(H-10) Examples of the stabilizer include dibutylhydroxytoluene, sodium edetate, sodium sulfite, and dry sodium sulfite.

(H-11) Examples of the buffering agent include borate buffering agent, phosphoric acid buffering agent, carbonic acid buffering agent, citric acid buffering agent, acetate buffering agent, epsilon-aminocaproic acid, aspartic acid, aspartate and the like. Can be done.

(H-12) Examples of other components include sodium carboxymethyl starch, magnesium stearate, cellulose, lactose, hard fat, D-sorbitol, medium-chain fatty acid triglyceride, corn starch and the like.

(I) Method for preparing and using O / W type emulsified composition The O / W type emulsified composition of the present invention contains the above components (A) to (D), and if necessary, (E) to (H). ), At least one of the components described in) is mixed, heated to a temperature of about 75 to 85 ° C., and then emulsified under predetermined conditions using a mixer such as a homogenizer, a homomixer, or a stirrer. It can be prepared by a well-known method.

Here, the hardness of the O / W type emulsified composition of the present invention is not particularly limited, but is usually adjusted to 15 to 120 g, preferably 20 to 100 g, and more preferably 30 to 80 g. .. The hardness is a value measured by the following method using a rheometer "Model: CR-500DX (Sun Science, adapter diameter 20 mm, circular)".

(Method)
40 g of a sample (emulsified composition) is placed in a circular jar container having a diameter of about 4 cm and a height of 3 cm, and measured at room temperature (around 25 ° C.) (constant depth measurement, measurement speed 38 mm / min). The maximum load (g) at the time of measurement is adopted as the measured value (1 measurement).

The O / W type emulsified composition of the present invention is a liquid to semi-solid oil-in-water emulsified composition, and can be suitably used as an external preparation for skin. Specific examples of the form of the external preparation for skin include semi-solid ointments and creams. As described above, the emulsified composition of the present invention has a semi-solid state, is easy to pick up at the time of use, has good spreadability, is less sticky, is easily adapted to the skin, and has an excellent usability. Further, it has an excellent application feeling (thickness feeling) that gradually adapts to the skin while having a shape-retaining feeling at the time of application and a feeling of being applied to the skin.

The O / W type emulsified composition of the present invention can be prepared in any of an external preparation, an external quasi-drug, and a cosmetic, depending on the intended purpose. The form of the cosmetic is not particularly limited, but for example, the skin care cosmetic may be a massage cream, a moisture cream, a lip balm, etc.; the makeup cosmetic may be a foundation, a lipstick, a blush, an eye shadow, or the like. Various cosmetic ingredients generally used in cosmetics can be appropriately blended into the above cosmetics.

Further, the O / W type emulsified composition is usually applied once to a plurality of times a day to the target skin in a timely manner. In this case, the amount of ceramide contained in the single application amount of the O / W type emulsified composition is not limited, but can be exemplified by about 1 to 30 mg / g.

(II) Method for improving usability / Method for improving feeling of application The present invention provides (A) a method for improving the feeling of use of an O / W type emulsified composition containing ceramides. The present invention also provides a method for improving the coating feeling of the O / W type emulsified composition containing (A) ceramides. Here, examples of the feeling of use include non-stickiness and / or a feeling of familiarity with the skin when used on the skin. Further, as a feeling of application, a feeling of thickness can be mentioned. The details are as described in (I), and the description can be incorporated herein by reference.

In the method, in preparation of the O / W type emulsified composition, (B) a nonionic surfactant, (C) shea butter, and (D) water are further added in addition to the above component (A). Can be carried out at. In addition to these components, it is characterized by further containing at least one selected from the group consisting of (E) anionic thickener, (F) hydrocarbon, and (G) polyhydric alcohol.

(A) ceramides, (B) nonionic surfactants, (C) shea butter, (D) water, (E) anionic thickeners, (F) hydrocarbons, and (F) hydrocarbons used in the methods of the present invention. G) The types of polyhydric alcohols and their blending ratios are as described in (I) above. Therefore, in the present invention, the description of (A), (B), (C), (D), (E), (F) and (G) in the above (I) can be incorporated.

In the method for improving the feeling of use / improving the feeling of application of the O / W type emulsified composition of the present invention, the method for preparing the target emulsified composition is also as described in (I) above. Therefore, in the present invention, the description in (I) above can be incorporated.

According to the method for improving usability of the present invention, as shown in an experimental example described later, stickiness when an O / W type emulsified composition containing ceramides is applied to the skin is suppressed, and skin compatibility is improved. Will be possible. According to the method for improving the coating feeling of the present invention, as shown in an experimental example described later, the feel (thickness) when the O / W type emulsifying composition containing ceramides is applied to the skin is O / W type emulsified. It can be added to the composition and improved.

Hereinafter, the present invention will be specifically described based on Experimental Examples and Examples. However, the present invention is not limited thereto.

Experimental Example 1 Preparation and evaluation of O / W type emulsified composition
(1) Preparation of test sample An O / W type emulsified composition (Examples 1 to 6 and Comparative Example 1) having the composition shown in Table 4 was prepared. Specifically, the aqueous phase (purified water, anionic thickener [acrylic acid / alkyl methacrylate copolymer, carboxyvinyl polymer, xanthan gum], pH adjuster) and oil phase (the aqueous phase component) prepared respectively. The components other than the above) were mixed and stirred until an emulsified state was obtained to prepare each O / W type emulsified composition (Examples 1 to 6, Comparative Example 1, both having a pH of 7).

(2) Test method Five cosmetics evaluation panelists were asked to apply each of the O / W type emulsified compositions prepared above to the back of their hands under the following test conditions, and their feeling of use (skin familiarity, stickiness) and The feeling of application (feeling of thickness) was evaluated according to the following criteria. For each of Examples 1 to 6 and Comparative Example 1, the scores of 5 panelists were totaled for each evaluation item. In addition, the total score of these evaluation items (skin familiarity, stickiness, thickness) was totaled for each Example (and Comparative Example 1), and used as a comprehensive evaluation of each O / W type emulsified composition.

(A) Test conditions Coating environment: temperature 25 ° C, relative humidity 40-50%
Application method: 0.2 g of the O / W type emulsified composition was placed on the back of the hand and applied in a circle in a range of 2 × 2 cm using the abdomen of the index finger of the opposite hand.

(B) Judgment criteria <Familiar with the skin>
As the emulsified composition placed on the back of the hand is spread with fingers, the sensation of the emulsified composition being absorbed by the skin is evaluated on a 5-point scale. The highest rating is given as a score of 5, and the lowest rating is given as a score of 1, and evaluation is performed in 1-point increments (the same applies to the "stickiness" and "thickness" below). Specifically, when the feeling is strong, it is defined as "5: good", and as the degree becomes weaker, "4: slightly good", "3: neither", "2: slightly bad", and "1: slightly bad". It's bad. " In addition, "bad" means that "the composition remains on the skin even if it is spread, and it takes a long time to finish the application, so that the feeling of being absorbed by the skin is bad".

<A feeling of stickiness>
The sticky sensation felt on the back of the hand when the emulsified composition is applied is evaluated on a 5-point scale. Specifically, the case where there is no or almost no sticky feeling is defined as "5: good", and as the sticky feeling increases, "4: slightly good", "3: neither", "2: slightly bad", And "1: bad" was judged.

<Thickness>
"Shape retention of the emulsified composition placed on the back of the hand", "Applying response when spreading", and "Applying feeling of the skin after application" are evaluated on a 5-point scale based on the following criteria. did.

The total score of each evaluation item and comprehensive evaluation was judged according to the following criteria.

(3) Test results Table 4 shows the results.

As can be seen from this result, (C) shea butter is added to an O / W type emulsified composition (Comparative Example 1) containing (A) ceramide, (B) nonionic surfactant, and (D) water. By doing so (Example 4), the feeling of use (stickiness, familiarity with the skin) was significantly improved, and at the time of application, a feeling of thickness was felt. Further, by blending (F) hydrocarbon with this, the feeling of use and thickness (Examples 2 and 3) were increased, and the effect was enhanced by increasing the amount of (F) hydrocarbon oil . Furthermore, by adding a polyhydric alcohol to this (Examples 1, 5 and 6), the feeling of use (non-stickiness, familiarity with the skin) was increased.
Examples 11-12
According to the formulations shown in Table 6 , the O / W type emulsified compositions of the present invention (Examples 11 to 12, pH 7 of Example 11) were prepared by the same method as in Experimental Example 1.

Claims (5)

A semi-solid O / W emulsified composition comprising the following components:
(A) Ceramides consisting of a combination of ceramides 2 and 3, or a combination of ceramides 1, 2 and 3 ,
(B) Nonionic surfactant,
(C) Shea fat ,
( D) Water and
(E) Anionic thickener,
(However, the emulsified composition containing ceramide 6II and ceramide EOS is excluded.) . The group in which the (E) anionic thickener comprises carboxymethyl cellulose, hyaluronic acid, alginic acid, xanthan gum, carrageenan, arabic rubber, guar gum, carboxyvinyl polymer, acrylate / alkyl methacrylate copolymer, and sodium polyacrylate. The O / W type emulsified composition according to claim 1, which is at least one selected from the above. The O / W type emulsified composition according to claim 1 or 2, further containing (F) a hydrocarbon oil . The O / W type emulsified composition according to any one of claims 1 to 3, further containing (G) a polyhydric alcohol. (A) is 0.1 to 3% by weight, (B) is 4 to 8% by weight , ( C) is 0.5 to 2% by weight , (D) is 20 to 90% by weight, and (E) is 0. The O / W type emulsified composition according to any one of claims 1 to 4, which is contained in a proportion of .025 to 1% by weight .