KR20190102564A - Multi-layer dressing material for wound treatment - Google Patents
Multi-layer dressing material for wound treatment Download PDFInfo
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- KR20190102564A KR20190102564A KR1020180023084A KR20180023084A KR20190102564A KR 20190102564 A KR20190102564 A KR 20190102564A KR 1020180023084 A KR1020180023084 A KR 1020180023084A KR 20180023084 A KR20180023084 A KR 20180023084A KR 20190102564 A KR20190102564 A KR 20190102564A
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- 206010052428 Wound Diseases 0.000 title claims abstract description 76
- 208000027418 Wounds and injury Diseases 0.000 title claims abstract description 76
- 239000000463 material Substances 0.000 title claims abstract description 28
- 210000001691 amnion Anatomy 0.000 claims abstract description 15
- 229920001661 Chitosan Polymers 0.000 claims abstract description 14
- 239000000843 powder Substances 0.000 claims abstract description 13
- 150000004676 glycans Chemical class 0.000 claims abstract description 6
- 229920001282 polysaccharide Polymers 0.000 claims abstract description 6
- 239000005017 polysaccharide Substances 0.000 claims abstract description 6
- 230000008929 regeneration Effects 0.000 claims abstract description 6
- 238000011069 regeneration method Methods 0.000 claims abstract description 6
- 125000002057 carboxymethyl group Chemical group [H]OC(=O)C([H])([H])[*] 0.000 claims abstract description 5
- 229920000642 polymer Polymers 0.000 claims abstract description 5
- 229920002101 Chitin Polymers 0.000 claims abstract description 4
- 239000010410 layer Substances 0.000 claims description 61
- FHVDTGUDJYJELY-UHFFFAOYSA-N 6-{[2-carboxy-4,5-dihydroxy-6-(phosphanyloxy)oxan-3-yl]oxy}-4,5-dihydroxy-3-phosphanyloxane-2-carboxylic acid Chemical compound O1C(C(O)=O)C(P)C(O)C(O)C1OC1C(C(O)=O)OC(OP)C(O)C1O FHVDTGUDJYJELY-UHFFFAOYSA-N 0.000 claims description 18
- 229940072056 alginate Drugs 0.000 claims description 18
- 229920000615 alginic acid Polymers 0.000 claims description 18
- 235000010443 alginic acid Nutrition 0.000 claims description 18
- 210000000416 exudates and transudate Anatomy 0.000 claims description 14
- 239000002861 polymer material Substances 0.000 claims description 12
- 239000002390 adhesive tape Substances 0.000 claims description 8
- 238000000034 method Methods 0.000 claims description 8
- 239000012790 adhesive layer Substances 0.000 claims description 7
- 238000001879 gelation Methods 0.000 claims description 2
- 239000004575 stone Substances 0.000 claims description 2
- 210000001519 tissue Anatomy 0.000 claims description 2
- 230000001737 promoting effect Effects 0.000 claims 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract description 6
- 230000000844 anti-bacterial effect Effects 0.000 abstract description 5
- 239000003102 growth factor Substances 0.000 abstract description 5
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- 239000000560 biocompatible material Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
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- 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
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- 238000006243 chemical reaction Methods 0.000 description 1
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- 150000001875 compounds Chemical class 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000000835 fiber Substances 0.000 description 1
- 230000002439 hemostatic effect Effects 0.000 description 1
- 230000008595 infiltration Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0213—Adhesive bandages or dressings with fluid retention members the fluid retention member being a layer of hydrocolloid, gel forming material
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/00051—Accessories for dressings
- A61F13/00063—Accessories for dressings comprising medicaments or additives, e.g. odor control, PH control, debriding, antimicrobic
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- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
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- A61F13/022—Adhesive bandages or dressings with fluid retention members having more than one layer with different fluid retention characteristics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/0203—Adhesive bandages or dressings with fluid retention members
- A61F13/0226—Adhesive bandages or dressings with fluid retention members characterised by the support layer
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
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- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
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- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
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- A61F13/00—Bandages or dressings; Absorbent pads
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Abstract
Description
본 발명은 피부 상처의 치료에 사용되는 드레싱재에 관한 것으로서, 보다 상세하게는 상호 다른 기능을 하는 물질로 이루어진 다층 구조를 가져 상처 치료의 효과를 높인 상처치료용 다층 드레싱재에 관한 것이다. The present invention relates to a dressing material used in the treatment of skin wounds, and more particularly, to a multi-layer dressing material for wound treatment having a multi-layer structure made of a material having a different function from each other to enhance the effect of wound treatment.
피부에 발생한 상처는, 염증기와 재생기를 거쳐 상피화 되면서 점차 낫게 되는데, 시기마다의 치료 타이밍을 놓칠 경우 감염 등의 2차적인 합병증을 발생하기 쉽다. 이에 따라 상처를 보다 적극적 효과적으로 치료하기 위하여 다양한 종류의 드레싱재가 사용되기도 한다.Wounds on the skin are gradually healed through inflammatory and rejuvenation phases, and secondary complications such as infections are likely to occur if the treatment timing is missed. Accordingly, various kinds of dressing materials may be used to treat the wound more actively and effectively.
상기 드레싱재가 갖추어야 할 요소에는 여러 가지가 있으며, 대표적으로, 생체적합성(biocompatibility)이 우수하여 거부반응이 없어야 하고, 상처부위로부터 삼출(渗出)하는 체액을 충분히 흡수할 수 있어야 하며, 그 자체가 피부에 안정적으로 밀착되어야 한다. 또한, 삼출된 체액의 증발을 최대화시키면서 상처 내부로 세균의 침입을 차단하여야 한다. The dressing material must have a number of elements, and typically, the biocompatibility should be excellent, there should be no rejection reaction, should be able to sufficiently absorb the body fluids exuded from the wound area, It should adhere securely to the skin. In addition, the infiltration of bacteria into the wound must be blocked while maximizing evaporation of the exuded body fluids.
한편, 기존에 사용되고 있는 거의 모든 드레싱재는, 단지 상처를 물리적으로 커버하여 습윤 환경을 유지하고, 2차 감염 등의 방지 정도만 수행하였다. 이를테면 상처의 신속한 지혈이나 삼출물의 효율적 관리, 항염항균 작용, 상처의 재생 촉진 등을 위한 구성을 갖추지 못해 능동적 상처 치료를 할 수 없었다.On the other hand, almost all the dressing materials used in the past, only physically covered the wound to maintain a wet environment, and performed only the degree of prevention of secondary infection and the like. For example, active wound treatment could not be performed due to the lack of a structure for rapid hemostasis of wounds, efficient management of exudate, anti-inflammatory antibacterial action, and promotion of wound regeneration.
본 발명은 상기 문제점을 해소하고자 창출한 것으로서, 상처부위의 습윤유지, 지혈, 삼출물 흡수, 조직재생, 성장인자(growthfactor)공급, 삼출물 관리, 항염 항균 작용, 2차감염방지 기능을 통해 상처를 능동적이고 효율적으로 치유하는 상처치료용 다층 드레싱재를 제공함에 목적이 있다.The present invention has been created to solve the above problems, the wound area through the maintenance of wetting, hemostasis, exudates absorption, tissue regeneration, growth factor supply, exudation management, anti-inflammatory antibacterial action, secondary infection prevention function It is an object of the present invention to provide a multi-layered dressing for wound healing that is effectively cured.
상기 목적을 달성하기 위한 본 발명의 상처치료용 다층 드레싱재는, 상처부위에 접한 상태로 겔(gel)화 되는 성질의 천연 다당류계 또는 키틴계 고분자물질과, 분말의 형태를 취하며 상기 고분자물질의 내부에 분산되고 고분자물질의 겔화에 따라 상처부위로 이동하여 상처의 재생을 촉진하는 양막(羊膜)분말을 포함하고, 상처부위를 커버할 수 있는 넓이와 두께를 갖는 밀착층과; 상기 밀착층의 상부에 적층된 상태로 밀착층을 지지하는 생체적합성 지지체층을 포함하는 것을 특징으로 한다.Multi-layer dressing material for wound treatment of the present invention for achieving the above object is a natural polysaccharide-based or chitin-based polymer material of the nature of being gelled in contact with the wound site, and takes the form of a powder An adhesion layer having an area and a thickness that are dispersed therein and include an amniotic powder that moves to a wound site and promotes wound regeneration as the polymer material gels, and covers the wound site; And a biocompatible support layer supporting the adhesion layer in a stacked state on the adhesion layer.
또한, 상기 천연 다당류계 고분자는, 상처부위의 습윤환경을 유지하는 알지네이트를 포함하는 것을 특징으로 한다.In addition, the natural polysaccharide-based polymer is characterized in that it comprises an alginate to maintain the wet environment of the wound site.
아울러, 상기 생체적합성 지지체층은, 상기 고분자물질의 겔화시, 상처로부터 발생하는 삼출물(渗出物) 관리를 동시에 수행하는 카르복시메틸 키토산으로 이루어진 CMCS층인 것을 특징으로 한다.In addition, the biocompatible support layer is characterized in that the CMCS layer made of carboxymethyl chitosan that simultaneously performs the management of exudates (渗出) generated from the wound when the polymer material gelling.
또한, 상기 생체적합성 지지체층은, 상처부위에서 발생하는 삼출물을 그 내부로 흡수할 수 있도록 스폰지상의 형태를 취하는 것을 특징으로 한다.In addition, the biocompatible support layer is characterized in that it takes the form of a sponge so as to absorb the exudates generated at the wound site therein.
또한, 상기 생체적합성 지지체층의 상부에는, 밀착층과 생체적합성 지지체층으로 구성된 적층체를 피부에 고정시키기 위한 접착테이프가 더 구비된 것을 특징으로 한다.In addition, the upper portion of the biocompatible support layer, characterized in that the adhesive tape for fixing the laminate consisting of the adhesion layer and the biocompatible support layer to the skin is further provided.
아울러, 상기 밀착층의 두께는 0.5mm 내지 2.0mm 인 것을 특징으로 한다.In addition, the thickness of the adhesive layer is characterized in that 0.5mm to 2.0mm.
또한, 상기 스톤지상을 이루는 생체적합성 지지체층의 공극율은 40% 내지 70%, 두께는 3mm 내지 5mm인 것을 특징으로 한다.In addition, the porosity of the biocompatible support layer forming the stone ground is characterized in that 40% to 70%, the thickness is 3mm to 5mm.
상기와 같이 이루어지는 본 발명의 상처치료용 다층 드레싱재는, 상처부위의 습윤유지, 지혈, 삼출물 흡수, 조직재생, 성장인자(growthfactor)공급 등의 복합 기능을 담당하는 밀착층과, 삼출물 관리, 항염 항균 작용, 2차감염방지 기능을 담당하는 CMCS(카르복시메틸 키토산)층이 적층구조를 이루며 각자의 역할을 통해 상처를 능동적이고 효율적으로 치유한다.Multi-layered dressing material for wound treatment of the present invention made as described above, the adhesion layer responsible for the complex functions such as maintaining the wet area of the wound, hemostasis, exudate absorption, tissue regeneration, growth factor (growth factor) supply, exudation management, anti-inflammatory antibacterial The CMCS (carboxymethyl chitosan) layer, which is responsible for its function and prevents secondary infections, forms a laminated structure and actively and efficiently heals wounds through its role.
도 1은 본 발명의 일 실시예에 따른 상처 치료용 다층 드레싱재의 구성 및 작용을 설명하기 위한 단면도이다.1 is a cross-sectional view for explaining the configuration and operation of a multi-layer dressing material for wound treatment according to an embodiment of the present invention.
이하, 본 발명에 따른 하나의 실시예를 첨부된 도면을 참조하여 보다 상세히 설명하기로 한다.Hereinafter, one embodiment according to the present invention will be described in detail with reference to the accompanying drawings.
기본적으로, 본 실시예에 따른 상처 치료용 다층 드레싱재(15)는, 상호 다른 기능을 갖는 두 개의 층을 겹친 적층구조를 갖는다. 특히 상기 두 개의 층이 갖는 개별적 효과는 동시에 작용하여 보다 능동적이고 신속한 상처치료를 가능케 한다.Basically, the wound dressing
이를테면, 후술하는 바와 같이, 양막의 생물학적 치유 성능(growth factor)과 CMCS 키토산 소재의 삼출물 관리, 지혈 및 항염항균 성능이 뛰어나, 특히 당뇨발, 욕창, 화상, 열상(쓸린 상처), 자가 치유능력이 현저히 떨어져 있는 만성상처의 치료에 매우 효과적이다.For example, as described below, the amniotic membrane's biological growth factor and CMCS chitosan exudative management, hemostasis and anti-inflammatory activity are excellent, especially diabetes foot, bedsores, burns, lacerations (swept wounds) and self-healing ability. It is very effective for the treatment of chronic wounds.
도 1은 본 발명의 일 실시예에 따른 상처치료용 다층 드레싱재의 구성 및 작용을 설명하기 위한 단면도이다.1 is a cross-sectional view for explaining the configuration and operation of the multi-layer dressing material for wound treatment according to an embodiment of the present invention.
도시한 바와 같이, 본 실시예에 따른 상처치료용 다층 드레싱재(15)는, 상처부위(13)를 커버하며 점착되는 밀착층(17)과, 상기 밀착층(17)의 상부에 적층되는 생체적합성 지지체층(19)과, 상기 생체적합성 지지체층(19) 상부에 위치하며 상기 적층체를 피부(11)에 안정적으로 고정시키기 위한 접착테이프(21)를 포함한다. 상기 접착테이프(21)는 경우에 따라 적용하거나 적용하지 않을 수도 있다.As shown, the wound dressing
먼저, 상기 밀착층(17)은, 천연 다당류계 고분자물질 또는 키틴계 고분자물질과, 선택된 고분자물질의 내부에 분포되는 양막(羊膜)분말(17b)로 구성된다. 본 실시예에서는 상기 고분자물질로서 알지네이트(17a)를 적용하였다. 하지만, 알지네이트와 유사한 기능을 수행할 수 있는 다른 종류의 고분자물질을 얼마든지 적용할 수 있음은 물론이다.First, the
상기 알지네이트(17a)는 우수한 생체 적합성을 가지는 물질로서, 상처부위(13)의 습윤 환경을 조성 및 유지하고, 우수한 점착력을 제공하여 드레싱재(15)의 고정을 안정적으로 유지한다.The alginate 17a is a material having excellent biocompatibility. The alginate 17a creates and maintains a wet environment of the
특히 상기 알지네이트(17a)는 상처부위에 밀착한 상태로 겔(Gel)화 되며 그 내부에 포함되어 있는 양막분말(17b)이, 도 1의 화살표 a방향으로 표시한 것처럼, 상처부위(13)의 조직 내부로 이동되게 한다. 상처부위(13)로 분산된 양막분말(17b)은 상처의 재생을 촉진하는 역할을 한다.In particular, the alginate 17a is gelled in close contact with the wound and the
상기와 같이 알지네이트(17a)가 겔화 됨에 따라, 상기 밀착층(17)은 하나의 습윤드레싱의 역할을 한다. 결국, 상기 알지네이트(17a)의 작용에 의해 상처부위가 촉촉하게 유지되어 상처면이 들러붙지 않고, 상처의 2차 손상을 막아 흉터 생성도 억제할 수 있다. As the alginate 17a gels as described above, the
상기 양막분말(羊膜, amnion)은, 녹지 않는(insoluble) 고형화 상태의 파티클의 형태를 취하며, 상처의 조직 내부로 퍼진 상태로 그 내부의 성분을 서서히 방출한다. The amnion powder takes the form of particles in an insoluble solidified state, and gradually releases the components therein while spreading into the wound tissue.
또한, 상기 밀착층(17)으로서, 키토산을 사용할 때의 조성비는, 키토산 1.25g, 알지네이트 0.1g, 양막 0.02g로 구성할 수 있다. 말하자면, 키토산 100중량부 당, 알지네이트 8중량부, 양막 1.6 중량부의 비율을 갖는 것이다.In addition, the composition ratio at the time of using chitosan as said
상기 키토산과 알지네이트의 비율이 달라지면, 유연성과 인장강도 등의 물리적인 특성이 다라진다. 가령, 키토산 비율이 높아지면 경도가 높아져 상처부에 밀착되기 힘들고 흡수력이 저하되며, 알지네이트 비율이 높으면 점성이 높아져서 양막 분산이 힘들고 경도 높아져 상처부에 밀착되기 힘들다. 상기 양막의 조성비는, 최소한의 양으로써 최대한의 효과를 나타낼 수 있는 비율이다. When the ratio of the chitosan and alginate is changed, physical properties such as flexibility and tensile strength are different. For example, if the ratio of chitosan increases, the hardness increases, making it difficult to adhere to the wound, and the absorbing power decreases. If the ratio of alginate is high, the viscosity increases, so that the amniotic membrane is difficult to disperse and the hardness increases. The composition ratio of the amnion is a ratio that can exhibit the maximum effect with a minimum amount.
또한, 상기 밀착층(17)의 넓이와 두께는, 상처부위(13)를 효과적으로 커버하며 보호할 수 있도록 드레싱재의 제품마다 달라질 수 있으며, 바람직한 두께는 가령 0.5mm 내지 2mm 정도일 수 있다. 밀착층이 양막분말(17b)을 포함하고 상처에 밀착되는 것이니 만큼, 상기 두께 보다 얇아지게 되면 양막의 탑재에 어려움이 있고, 지나치게 두꺼워지면 알지네이트 층에 의해 키토산 층의 삼출물을 흡수하는 능력이 줄어들 수 있다.In addition, the width and thickness of the
한편, 상기 생체적합성 지지체층(19)은, 카르복시메틸 키토산(Carboxymethyl Chitosan)(이하, CMCS)으로 이루어진 스폰지 상의 층이다. 상기 CMCS은 일반 키토산에 비해 우수한 생체 적합성을 가지고, 뛰어난 흡수성을 통한 상처부위의 삼출물 관리, 항염 항균 작용, 지혈작용을 하는 물질이다.On the other hand, the
상기 CMCS가 갖는 효과는 알지네이트의 겔화시, 겔 층을 통해 상처부위에 작용한다. 말하자면, 상처부위(13) 내부의 삼출물을 적절히 관리하여, 삼출물 내 세포재생에 필요한 여러 인자를 효과적으로 활용할 수 있는 환경을 만들어주거나, 상처부위(13)로부터 삼출물을 흡수하는 것이다. 상기 생체적합성 지지체층(19)이 삼출물을 흡수할 수 있도록 CMCS은 스폰지상의 형태를 취한다. The effect of the CMCS is on the wound site through the gel layer when gelling alginate. In other words, by properly managing the exudate in the wound (13), to create an environment that can effectively utilize the various factors required for cell regeneration in the exudate, or to absorb the exudate from the wound (13). The CMCS takes the form of a sponge so that the
결국 상기 알지네이트의 겔화에 따라, 약막과 CMCS의 효과가 상처부위에 동시에 전달된다. 말하자면, 알지네이트의 겔화에 따라, 양막분말(17b)이 상처부위에 분산되어 작용하기 시작하며 이와 함께 CMCS도 작용 하는 것이다.Eventually, as the alginate gels, the effects of the drug and the CMCS are simultaneously delivered to the wound. In other words, according to the gelation of alginate, the
상기 생체적합성 지지체층(19)의 넓이는 밀착층(17)과 동일하고, 두 께는 외부의 충격으로부터 상처부위(13)를 안정적으로 보호할 수 있도록 충분히 두껍게 제작할 수 있다. 생체적합성 지지체층(19)의 공극률은 40% 내지 70% 이고, 바람직한 두께는 3mm 내지 5mm 이다. 지지제층(19) 자체가 삼출물을 흡수하고 습윤환경을 조절하기 위해 특화된 부분이기 때문에, 상기 두께보다 얇아질 경우 흡수 능력이 저하되고, 두꺼워질 경우에는 두꺼움으로 인해 상처부에 밀착하기 힘들어진다. The width of the
이 흡수는, 지지체층(19)이 갖는 공극에 의한 모세관 현상으로 인한 것이다. 공극이 지나치게 커질 경우 모세관현상이 저하되게 되어 흡수력이 작아지고, 공극이 지나치게 적을 경우에는 흡수력이 줄어든다.This absorption is due to the capillary phenomenon caused by the voids of the
상기 접착테이프(21)는, 상기 밀착층(17) 및 생체적합성 지지체층(19)이 이루는 적층체를 피부(11)에 안정적으로 고정시키기 위한 의료용 테이프이다. 상기 접착테이프(21)는, 생체적합성 물질을 원료로 하여 제조된 시트로서, 충분한 수분의 증발 능력을 가지며 특히 세균의 침투를 차단한다. 물론, 상기 상처부위(13)의 표면에 대한 밀착층(17)의 점착력이 충분할 경우 접착테이프(21)를 사용하지 않을 수도 있다. The
이상, 본 발명을 구체적인 실시예를 통하여 상세하게 설명하였으나, 본 발명은 상기 실시예에 한정하지 않고, 본 발명의 기술적 사상의 범위내에서 통상의 지식을 가진 자에 의하여 여러 가지 변형이 가능하다.As mentioned above, although this invention was demonstrated in detail through the specific Example, this invention is not limited to the said Example, A various deformation | transformation is possible for a person with ordinary knowledge within the scope of the technical idea of this invention.
11:피부 13:상처부위
15:다층드레싱재 17:밀착층
17a:알지네이트 17b:양막분말
19:생체적합성 지지체층 21:접착테이프
Z:삼출물11: skin 13: wound
15: multilayer dressing material 17: adhesive layer
17a:
19: biocompatible support layer 21: adhesive tape
Z: Exudate
Claims (8)
상기 밀착층의 상부에 적층된 상태로 밀착층을 지지하는 생체적합성 지지체층을 포함하는 것을 특징으로 하는 상처치료용 다층 드레싱재.Natural polysaccharide-based or chitin-based polymer material having a gelling property in contact with the wound area, and takes the form of a powder and is dispersed in the polymer material and moves to the wound site according to the gelation of the polymer material. An adhesion layer comprising an amnion powder for promoting regeneration of the tissue, and having an area and a thickness capable of covering the wound site;
Multi-layer dressing material for wound treatment, characterized in that it comprises a biocompatible support layer for supporting the adhesion layer in a stacked state on top of the adhesion layer.
상기 천연 다당류계 고분자는, 상처부위의 습윤환경을 유지하는 알지네이트를 포함하는 것을 특징으로 하는 상처치료용 다층 드레싱재.The method of claim 1,
The natural polysaccharide-based polymer, wound dressing multi-layer dressing material, characterized in that it comprises an alginate to maintain the wet environment of the wound.
상기 생체적합성 지지체층은,
상기 고분자물질의 겔화시, 상처로부터 발생하는 삼출물(渗出物) 관리를 동시에 수행하는 카르복시메틸 키토산으로 이루어진 CMCS층인 것을 특징으로 하는 상처치료용 다층 드레싱재.The method of claim 1,
The biocompatible support layer,
Multi-layer dressing material for wound treatment, characterized in that the gelling of the polymer material, the CMCS layer consisting of carboxymethyl chitosan simultaneously performing exudation (渗出 物) management from the wound.
상기 생체적합성 지지체층은, 상처부위에서 발생하는 삼출물을 그 내부로 흡수할 수 있도록 스폰지상의 형태를 취하는 것을 특징으로 하는 상처치료용 다층 드레싱재.The method of claim 3,
The biocompatible support layer is wound multi-layer dressing material, characterized in that to take the form of a sponge to absorb the exudates generated in the wound portion therein.
상기 생체적합성 지지체층의 상부에는, 밀착층과 생체적합성 지지체층으로 구성된 적층체를 피부에 고정시키기 위한 접착테이프가 더 구비된 것을 특징으로 하는 상처치료용 다층 드레싱재.The method of claim 1,
The upper portion of the biocompatible support layer, the wound wound multi-layer dressing material, characterized in that the adhesive tape for fixing the laminate composed of the adhesive layer and the biocompatible support layer to the skin is further provided.
상기 밀착층의 두께는 0.5mm 내지 2.0mm 인 것을 특징으로 하는 상처치료용 다층 드레싱재.The method of claim 1,
Multi-layer dressing material for wound treatment, characterized in that the thickness of the adhesive layer is 0.5mm to 2.0mm.
상기 스톤지상을 이루는 생체적합성 지지체층의 공극율은 40% 내지 70%인 것을 특징으로 하는 상처치료용 다층 드레싱재.The method of claim 4, wherein
Multi-layer dressing material for wound treatment, characterized in that the porosity of the biocompatible support layer forming the stone ground is 40% to 70%.
상기 생체적합성 지지체층의 두께는 3mm 내지 5mm인 것을 특징으로 하는 상처치료용 다층 드레싱재.
The method of claim 7, wherein
Multi-layer dressing material for wound treatment, characterized in that the thickness of the biocompatible support layer is 3mm to 5mm.
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| CN116077717A (en) * | 2021-11-05 | 2023-05-09 | 重庆医科大学附属口腔医院 | Bioburden system for wound healing and application thereof |
| CN116077717B (en) * | 2021-11-05 | 2024-01-30 | 重庆医科大学附属口腔医院 | Bioburden system for wound healing and application thereof |
| CN114225103A (en) * | 2021-12-31 | 2022-03-25 | 湖北省银丰鼎诚生物工程有限公司 | Amnion-graphene oxide hydrogel medical biological dressing |
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| KR102090576B1 (en) | 2020-03-18 |
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