KR20190076103A - A Pharmaceutical composition comprising mixed herbal extract for preventing or treating lung cancer - Google Patents
A Pharmaceutical composition comprising mixed herbal extract for preventing or treating lung cancer Download PDFInfo
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- KR20190076103A KR20190076103A KR1020170177633A KR20170177633A KR20190076103A KR 20190076103 A KR20190076103 A KR 20190076103A KR 1020170177633 A KR1020170177633 A KR 1020170177633A KR 20170177633 A KR20170177633 A KR 20170177633A KR 20190076103 A KR20190076103 A KR 20190076103A
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- lung cancer
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- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
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- A23V2200/00—Function of food ingredients
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Abstract
Description
본 발명은 혼합 생약 추출물을 포함하는 폐암 예방 또는 치료용 약학적 조성물에 관한 것으로서, 보다 구체적으로는 황기, 인삼 및 백출 혼합 추출물을 포함하는 폐암 예방 또는 치료용 약학적 조성물에 관한 것이다.The present invention relates to a pharmaceutical composition for preventing or treating lung cancer, which comprises a mixed herbal medicine extract, and more particularly, to a pharmaceutical composition for prevention or treatment of lung cancer, which comprises a mixture of Hwanggi,
폐암은 또는 폐 암종(carcinoma of the lung 또는 pulmonary carcinoma)이라고도 하며, 폐 조직에서 조절되지 않는 세포 성장을 특징으로 하는 악성 폐 종양이다. 폐암은 전 세계적으로 암 관련 사망의 주요 원인이다. 약 85%의 경우는 흡연과 관련되어 있다. 증상은 일반적으로 기침, 흉부 불편감이나 통증, 체중 감소를 나타내며, 객혈을 포함할 수 있다. 그러나, 많은 환자는 임상 증상없이 전이성 질환을 나타낸다.Lung cancer, also called carcinoma of the lung or pulmonary carcinoma, is a malignant lung tumor characterized by uncontrolled cell growth in lung tissue. Lung cancer is the leading cause of cancer-related deaths worldwide. About 85% are associated with smoking. Symptoms usually indicate cough, chest discomfort or pain, weight loss, and may include hemoptysis. However, many patients present with metastatic disease without clinical symptoms.
폐암은 암세포의 현미경학적 세포형태에 따라 크게 비소세포 폐암(non-small cell carcinoma)과 소세포 폐암(small cell carcinoma)으로 구분하는데 비소세포 폐암은 전체 폐암의 약 80%를 차지하며 편평상피세포암(squamous cell carcinoma), 선암(adenocarcinoma) 및 대세포암(large-cell carcinoma)의 3가지 아형이 있다.Lung cancer is classified into non-small cell carcinoma and small cell carcinoma according to microscopic cell types of cancer cells. Non-small cell lung cancer accounts for about 80% of total lung cancer and squamous cell carcinoma squamous cell carcinoma, adenocarcinoma, and large-cell carcinoma.
소세포 폐암은 전체 폐암의 약 20%를 차지하며 주로 기도(기관지나 세기관지)에서 처음 발병한다. 암종은 대개 기관의 표면이나 선을 따라 생성되어, 대부분(4/5) 폐 중앙부에 생기고, 나머지(1/5)는 말초에 생긴다. 전반적으로 악성도가 강해서 성장속도가 빠르고 림프계통이나 혈액순환을 통해 조기에 멀리 전이되는 경향이 있다. 이러한 폐암의 치료방법으로는 수술, 방사선 요법 및 항암화학요법이 사용되고 있으나, 비소세포 폐암의 경우 완전한 수술적 절제가 가능하였던 환자들의 경우에도 다수의 환자가 수술 후 재발하기 때문에 결국 1기에서 60-70%, 2기에서 30-50%, 3기에서 10-30%의 환자에서만 장기 생존이 가능하다. 전체적으로 보면 5년 생존율은 30% 밖에 안되며 10년 생존율은 15%에 불과하다. 이와 같이 불량한 치료 성적을 향상시키고자 많은 노력이 이루어지고 있는데, 수술을 전후하여 항암화학요법이나 방사선요법의 병용 등으로 일부에서 효과가 입증되었으나 여러 가지 부작용을 유발하며, 치료율도 여전히 불만족스러운 실정이다.Small cell lung cancer accounts for about 20% of all lung cancers, and it usually develops primarily in the airways (trachea or bronchus). Carcinomas are usually produced along the surface or line of an organ, most (4/5) in the middle of the lung, and the rest (1/5) in the periphery. Overall, malignancy is so rapid that it tends to grow at a rapid rate and to migrate away early through the lymphatic system or blood circulation. However, in the case of non-small cell lung cancer, even in patients who were able to undergo complete surgical resection, many patients recurred after surgery, Long-term survival is possible in only 70% of patients, 30-50% in stage 2, and 10-30% in stage 3. Overall, the 5-year survival rate is only 30% and the 10-year survival rate is only 15%. Although there have been a number of attempts to improve the outcome of such poor treatment, some have been proven effective in some cases, such as the combination of chemotherapy and radiotherapy before and after surgery, but these side effects are still present and the treatment rate is still unsatisfactory .
따라서, 독성과 부작용이 적으면서 폐암에 대한 항암효과를 나타내는 천연물을 찾아내기 위하여 많은 연구가 진행되고 있으며, 특히, 비교적 인체에 안전한 한약재를 이용한 항암 치료약 및 항암 치료보조제 개발 연구가 활발하게 진행되고 있으나(한국공개번호 제10-2012-0109142호), 아직 미비한 실정이다.Therefore, a lot of research has been carried out to find a natural product exhibiting an anticancer effect against lung cancer while having less toxicity and side effects. Particularly, development of an anticancer drug and an adjuvant for chemotherapy using a medicinal herb which is relatively safe to human body is actively carried out (Korean Utility Model No. 10-2012-0109142), but it is still not yet available.
본 발명은 상기와 같은 문제점을 해결하기 위해 안출된 것으로서, 본 발명자들은 폐암의 예방, 개선 또는 치료에 효과적인 생약 추출물 소재를 발굴하기 위해 연구 노력한 결과, 황기, 인삼 및 백출 혼합 추출물이 폐암 치료에 효과적임을 확인하고, 이에 기초하여 본 발명을 완성하게 되었다.DISCLOSURE OF THE INVENTION The present invention has been made in order to solve the above problems, and the present inventors have made efforts to find out an effective herbal extract material for prevention, improvement or treatment of lung cancer. As a result, And the present invention has been completed on the basis thereof.
이에, 본 발명은 황기, 인삼 및 백출 혼합 추출물을 포함하는 폐암 예방 또는 치료용 약학적 조성물을 제공하는 것을 목적으로 한다.Accordingly, it is an object of the present invention to provide a pharmaceutical composition for prevention or treatment of lung cancer, which comprises a mixture of Hwanggi, ginseng, and alfalfa.
또한, 본 발명은 황기, 인삼 및 백출 혼합 추출물을 포함하는 폐암 예방 또는 개선용 건강식품 조성물을 제공하는 것을 또 다른 목적으로 한다.It is still another object of the present invention to provide a health food composition for preventing or ameliorating lung cancer, which comprises a mixture of Hwanggi, ginseng, and alfalfa.
그러나 본 발명이 이루고자 하는 기술적 과제는 이상에서 언급한 과제에 제한되지 않으며, 언급되지 않은 또 다른 과제들은 아래의 기재로부터 당업자에게 명확하게 이해될 수 있을 것이다.However, the technical problem to be solved by the present invention is not limited to the above-mentioned problems, and other matters not mentioned can be clearly understood by those skilled in the art from the following description.
상기와 같은 본 발명의 목적을 달성하기 위하여, 본 발명은 황기, 인삼 및 백출 혼합 추출물을 포함하는 폐암 예방 또는 치료용 약학적 조성물을 제공한다.In order to achieve the object of the present invention, the present invention provides a pharmaceutical composition for preventing or treating lung cancer, which comprises a mixture of Hwanggi, ginseng, and white algae.
본 발명의 일 구현예로, 상기 추출물은 물, 탄소수 1 내지 4의 알코올 및 이들의 혼합 용매로 이루어진 군으로부터 선택된 용매로 추출될 수 있다.In one embodiment of the present invention, the extract may be extracted with a solvent selected from the group consisting of water, an alcohol having 1 to 4 carbon atoms, and a mixed solvent thereof.
본 발명의 다른 구현예로, 상기 추출물은 폐암 세포의 성장을 억제할 수 있다.In another embodiment of the present invention, the extract may inhibit the growth of lung cancer cells.
본 발명은 황기, 인삼 및 백출 혼합 추출물을 포함하는 폐암 예방 또는 개선용 건강식품 조성물을 제공한다.The present invention provides a health food composition for preventing or ameliorating lung cancer, which comprises a mixture of Hwanggi, ginseng, and alfalfa.
본 발명은 황기, 인삼 및 백출 혼합 추출물을 개체에 투여하는 단계를 포함하는 폐암 예방 또는 치료방법을 제공한다.The present invention provides a method for preventing or treating lung cancer comprising administering to a subject a mixture of yellow moss, ginseng, and white moss.
본 발명은 황기, 인삼 및 백출 혼합 추출물의 폐암 예방 또는 치료용도를 제공한다.The present invention provides a method for preventing or treating lung cancer in combination with Hwanggi, Ginseng, and Lycopodium mixture extract.
본 발명에 따른 조성물은 황기, 인삼 및 백출 혼합 추출을 유효성분으로 포함하며, 상기 혼합 추출물은 폐암 세포의 성장을 억제할 수 있는바, 폐암 예방, 개선 또는 치료용 조성물의 유효성분으로 유용하게 사용될 수 있을 것으로 기대된다.The composition according to the present invention contains a mixture of yellow, green, and white mixed extracts as an active ingredient. The mixed extract can inhibit the growth of lung cancer cells, and is useful as an effective ingredient of compositions for preventing, improving or treating lung cancer It is expected to be possible.
본 발명은 황기, 인삼 및 백출 혼합 추출물을 포함하는 폐암 예방 또는 치료용 약학적 조성물을 제공한다.The present invention provides a pharmaceutical composition for prevention or treatment of lung cancer, which comprises a mixture of Hwanggi, ginseng, and alfalfa.
본 발명에서 사용되는 용어, "예방"이란 본 발명에 따른 약학적 조성물의 투여에 의해 폐암을 억제시키거나 발병을 지연시키는 모든 행위를 의미한다.As used herein, the term "prophylactic " means any act that inhibits lung cancer or delays its development by administration of the pharmaceutical composition according to the present invention.
본 발명에서 사용되는 용어, "치료"란 본 발명에 따른 약학적 조성물의 투여에 의해 폐암에 의한 증세가 호전되거나 이롭게 변경되는 모든 행위를 의미한다.The term "treatment" used in the present invention means all the actions of improving or alleviating symptoms caused by lung cancer by administration of the pharmaceutical composition according to the present invention.
본 발명에서, 추출물은 천연물로부터 추출물을 추출하는 당업계에 공지된 통상적인 방법에 따라, 즉, 통상적인 온도, 압력의 조건 하에서 통상적인 용매를 사용하여 추출할 수 있다. 예컨대, 본 발명에서, 추출물은 물, 탄소수 1 내지 4의 알코올 및 이들의 혼합용매로부터 선택된 1종 이상의 용매를 이용할 수 있다. 또한, 추출물을 추출하는 방법은 열수 추출, 냉침 추출, 환류 추출, 초음파 추출 등의 다양한 방법을 통하여 추출할 수 있지만, 이것으로 제한되는 것은 아니다.In the present invention, the extract can be extracted using conventional solvents known in the art for extracting the extract from natural products, that is, under ordinary temperature and pressure conditions. For example, in the present invention, the extract may be at least one solvent selected from water, alcohols having 1 to 4 carbon atoms, and mixed solvents thereof. In addition, the method of extracting the extract can be carried out by various methods such as hot water extraction, cold extraction, reflux extraction, ultrasonic extraction and the like, but is not limited thereto.
상기 제조된 추출물은 이후 여과하거나 농축 또는 건조과정을 수행하여 용매를 제거할 수 있으며, 여과, 농축 및 건조를 모두 수행할 수 있다. 예컨대, 여과는 여과지를 이용하거나 감압여과기를 이용할 수 있으며, 농축은 감압 농축기, 건조는 동결건조법 등을 수행할 수 있으나, 이것으로 제한되는 것은 아니다.The extract thus prepared may be filtered, concentrated or dried to remove the solvent, and may be subjected to both filtration, concentration and drying. For example, the filtration can be performed using a filter paper or a vacuum filter, the concentration can be carried out using a vacuum concentrator, and the lyophilization can be carried out, but the present invention is not limited thereto.
또한, 상기 용매로 추출한 추출물은 이후, 헥산, 메틸렌클로라이드, 아세톤, 에틸아세테이트, 에틸 에테르, 클로로포름, 물 및 이들의 혼합물로 이루어진 군으로부터 선택된 용매로 분획과정을 더욱 실시할 수도 있다. 상기 분획 시 온도는 4℃ 내지 120℃일 수 있으나, 이에 제한되지는 않는다.Further, the extract extracted with the solvent may be further fractionated with a solvent selected from the group consisting of hexane, methylene chloride, acetone, ethyl acetate, ethyl ether, chloroform, water, and mixtures thereof. The fractionation temperature may be 4 캜 to 120 캜, but is not limited thereto.
본 발명에 따른 혼합 추출물은 황기, 인삼 및 백출이 0.5~1.5 : 0.5~1.5 : 0.5~1.5의 중량비로 포함될 수 있으며, 바람직하게는 1:1:1의 비율로 포함될 수 있다.The mixed extract according to the present invention may be contained in a weight ratio of 0.5 to 1.5: 0.5 to 1.5: 0.5 to 1.5, preferably 1: 1: 1.
본 발명에 따른 황기, 인삼 및 백출 혼합 추출물은 폐암 세포주의 성장을 억제할 수 있는바, 폐암 예방 또는 치료용 조성물의 유효성분으로 유용하게 사용될 수 있다.According to the present invention, the combination of Hwanggi, Ginseng and Lycopene can inhibit the growth of lung cancer cell line, and thus can be effectively used as an active ingredient of a composition for preventing or treating lung cancer.
본 발명에 따른 약학적 조성물은 유효성분 이외에 약제학적으로 허용되는 담체를 포함할 수 있다. 이때, 약제학적으로 허용되는 담체는 제제 시에 통상적으로 이용되는 것으로서, 락토스, 덱스트로스, 수크로스, 솔비톨, 만니톨, 전분, 아카시아고무, 인산 칼슘, 알기네이트, 젤라틴, 규산 칼슘, 미세 결정성셀룰로스, 폴리비닐피로리돈, 셀룰로스, 물, 시럽, 메틸 셀룰로스, 메틸히드록시벤조에이트, 프로필 히드록시벤조에이트, 활석, 스테아르산 마그네슘 및 미네랄 오일 등을 포함하나, 이에 한정되는 것은 아니다. 또한, 상기성분들 이외에 윤활제, 습윤제, 감미제, 향미제, 유화제, 현탁제, 보존제 등을 추가로 포함할 수 있다.The pharmaceutical composition according to the present invention may contain, in addition to the active ingredient, a pharmaceutically acceptable carrier. Herein, pharmaceutically acceptable carriers are those conventionally used at the time of formulation, such as lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia rubber, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose But are not limited to, polyvinylpyrrolidone, cellulose, water, syrup, methylcellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate and mineral oil. Further, in addition to the above components, a lubricant, a wetting agent, a sweetener, a flavoring agent, an emulsifying agent, a suspending agent, a preservative, and the like may be further included.
본 발명의 약학적 조성물은 목적하는 방법에 따라 경구 투여하거나 비경구투여(예를 들어, 정맥 내, 피하, 복강 내 또는 국소에 적용)할 수 있으며, 투여량은 환자의 상태 및 체중, 질병의 정도, 약물형태, 투여경로 및 시간에 따라 다르지만, 당업자에 의해 적절하게 선택될 수 있다.The pharmaceutical composition of the present invention may be administered orally or parenterally (for example, intravenously, subcutaneously, intraperitoneally or topically) depending on the intended method, and the dose may vary depending on the condition and the weight of the patient, The mode of administration, the route of administration, and the time, but may be appropriately selected by those skilled in the art.
본 발명의 약학적 조성물은 약학적으로 유효한 양으로 투여한다. 본 발명에 있어서 "약학적으로 유효한 양"은 의학적 치료에 적용 가능한 합리적인 수혜/위험 비율로 질환을 치료하기에 충분한 양을 의미하며, 유효용량 수준은 환자의 질환의 종류, 중증도, 약물의 활성, 약물에 대한 민감도, 투여 시간, 투여 경로 및 배출비율, 치료기간, 동시 사용되는 약물을 포함한 요소 및 기타 의학 분야에 잘 알려진 요소에 따라 결정될 수 있다.The pharmaceutical composition of the present invention is administered in a pharmaceutically effective amount. In the present invention, the term "pharmaceutically effective amount" means an amount sufficient to treat a disease at a reasonable benefit / risk ratio applicable to medical treatment, and the effective dose level will depend on the type of disease, severity, The sensitivity to the drug, the time of administration, the route of administration and the rate of release, the duration of the treatment, factors including co-administered drugs, and other factors well known in the medical arts.
본 발명에 따른 약학적 조성물은 개별 치료제로 투여하거나 다른 치료제와 병용하여 투여될 수 있고 종래의 치료제와는 순차적 또는 동시에 투여될 수 있으며, 단일 또는 다중 투여될 수 있다. 이때 사용할 수 있는 종래 치료제는 케피티닙(gefitinib)일 수 있으나, 이것으로 제한되는 것은 아니다.The pharmaceutical composition according to the present invention can be administered as an individual therapeutic agent or in combination with other therapeutic agents, and can be administered sequentially or simultaneously with conventional therapeutic agents, and can be administered singly or in multiple doses. The conventional therapeutic agent that can be used at this time may be, but is not limited to, gefitinib.
본 발명의 다른 양태로서, 본 발명은 황기, 인삼 및 백출 혼합 추출물을 개체에 투여하는 단계를 포함하는 폐암의 예방 또는 치료방법을 제공한다.In another aspect of the present invention, the present invention provides a method of preventing or treating lung cancer, comprising administering an extract of yellow blossom, ginseng and alfalfa to a subject.
본 발명에서 "개체"란 질병의 치료를 필요로 하는 대상을 의미하고, 보다 구체적으로는 인간 또는 비-인간인 영장류, 생쥐 (mouse), 쥐 (rat), 개, 고양이, 말 및 소 등의 포유류를 의미한다.The term "individual" as used herein refers to a subject in need of treatment for a disease, and more specifically refers to a human or non-human primate, mouse, rat, dog, cat, It means mammals.
본 발명의 다른 양태로서, 본 발명은 황기, 인삼 및 백출 혼합 추출물을 유효성분으로 포함하는 폐암 예방 또는 개선용 건강식품 조성물을 제공한다.According to another aspect of the present invention, there is provided a health food composition for preventing or ameliorating lung cancer, which comprises an extract of Huangji, ginseng, and liquorice as an active ingredient.
본 발명의 기능성 식품 조성물에서 유효성분을 식품에 그대로 첨가하거나 다른 식품 또는 식품 성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효 성분의 혼합량은 그의 사용 목적(예방 또는 개선용)에 따라 적합하게 결정될 수 있다. 일반적으로, 식품 또는 음료의 제조시에 본 발명의 조성물은 원료에 대하여 15 중량% 이하, 바람직하게는 10 중량% 이하의 양으로 첨가된다. 그러나 건강 및 위생을 목적으로 하거나 또는 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 양은 상기 범위 이하일 수 있다.In the functional food composition of the present invention, the active ingredient may be directly added to the food or may be used together with other food or food ingredients, and may be suitably used according to a conventional method. The amount of the active ingredient to be mixed can be suitably determined according to the intended use (for prevention or improvement). In general, the composition of the present invention is added in an amount of not more than 15% by weight, preferably not more than 10% by weight based on the raw material, in the production of food or beverage. However, in the case of long-term consumption intended for health and hygiene purposes or for health control purposes, the amount may be less than the above range.
본 발명의 기능성 식품 조성물은 지시된 비율로 필수 성분으로서 상기 유효성분을 함유하는 것 외에 다른 성분에는 특별한 제한이 없으며 통상의 음료와 같이 여러 가지 향미제 또는 천연 탄수화물 등을 추가 성분으로서 함유할 수 있다. 상술한 천연 탄수화물의 예는 모노사카라이드, 예를 들어, 포도당, 과당 등; 디사카라이드, 예를 들어 말토스, 슈크로스 등; 및 폴리사카라이드, 예를 들어 덱스트린, 시클로덱스트린 등과 같은 통상적인 당, 및 자일리톨, 소르비톨, 에리트리톨 등의 당알콜이다. 상술한 것 이외의 향미제로서 천연 향미제(타우마틴, 스테비아 추출물(예를 들어 레바우디오시드 A, 글리시르히진등) 및 합성 향미제(사카린, 아스파르탐 등)를 유리하게 사용할 수 있다. 상기 천연 탄수화물의 비율은 당업자의 선택에 의해 적절하게 결정될 수 있다.The functional food composition of the present invention has no particular limitation on the ingredients other than those containing the active ingredient as an essential ingredient in the indicated ratios and may contain various flavors or natural carbohydrates as an additional ingredient such as ordinary drinks . Examples of the above-mentioned natural carbohydrates include monosaccharides such as glucose, fructose and the like; Disaccharides such as maltose, sucrose and the like; And polysaccharides, for example, conventional sugars such as dextrin, cyclodextrin and the like, and sugar alcohols such as xylitol, sorbitol and erythritol. Natural flavors (tau martin, stevia extracts (e.g., rebaudioside A, glycyrrhizin, etc.) and synthetic flavors (saccharin, aspartame, etc.) can be advantageously used as flavors other than those described above . The ratio of the above-mentioned natural carbohydrate can be appropriately determined by a person skilled in the art.
상기 외에 본 발명의 기능성 식품 조성물은 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 중진제(치즈, 초콜릿 등), 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 함유할 수 있다. 이러한 성분은 독립적으로 또는 조합하여 사용할 수 있다. 이러한 첨가제의 비율 또한 당업자에 의해 적절히 선택될 수 있다.In addition to the above, the functional food composition of the present invention may contain flavoring agents such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, colorants and heavies (cheese, chocolate etc.), pectic acid and its salts, And salts thereof, organic acids, protective colloid thickeners, pH adjusting agents, stabilizers, preservatives, glycerin, alcohols, carbonating agents used in carbonated drinks, and the like. These components may be used independently or in combination. The ratios of these additives can also be appropriately selected by those skilled in the art.
이하, 본 발명의 이해를 돕기 위하여 바람직한 실시예를 제시한다. 그러나 하기의 실시예는 본 발명을 보다 쉽게 이해하기 위하여 제공되는 것일 뿐, 하기 실시예에 의해 본 발명의 내용이 한정되는 것은 아니다.Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided only for the purpose of easier understanding of the present invention, and the present invention is not limited by the following examples.
[실시예][Example]
실시예 1. 혼합 추출물 제조Example 1. Preparation of mixed extract
황기, 인삼 및 백출을 용매로 추출하여 감압농축 후 건조하여 혼합 추출물을 제조하였다.Hwanggi, ginseng and liquorice were extracted with a solvent, concentrated under reduced pressure and dried to prepare a mixed extract.
실시예 2. 폐암에 대한 혼합 추출물의 항암 활성 확인Example 2. Confirmation of anticancer activity of mixed extracts against lung cancer
상기 실시예 1에 의해 제조된 혼합 추출물의 폐암 치료 효과를 확인하였다.The effect of the mixed extract prepared in Example 1 on lung cancer was confirmed.
전술한 본 발명의 설명은 예시를 위한 것이며, 본 발명이 속하는 기술분야의 통상의 지식을 가진 자는 본 발명의 기술적 사상이나 필수적인 특징을 변경하지 않고서 다른 구체적인 형태로 쉽게 변형이 가능하다는 것을 이해할 수 있을 것이다. 그러므로 이상에서 기술한 실시예들은 모든 면에서 예시적인 것이며 한정적이 아닌 것으로 이해해야만 한다.It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive.
Claims (4)
A pharmaceutical composition for the prevention or treatment of lung cancer, comprising a mixture of Hwanggi, ginseng and alfalfa.
The composition according to claim 1, wherein the extract is extracted with a solvent selected from the group consisting of water, an alcohol having 1 to 4 carbon atoms, and a mixed solvent thereof.
2. The composition of claim 1, wherein said extract inhibits the growth of lung cancer cells.
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