KR20190064054A - A emulsion type composition of enhanced stability comprising effective substances with low pH - Google Patents

Abstract

The present invention relates to an emulsion composition. The emulsion composition comprises an oil part containing a cationic emollient, an aqueous part containing an anionic thickener, and active substances present in the oil part or the aqueous part, wherein the emulsion composition has pH of 5.5 or less and secures excellent emulsion stability.

Description

[0001] The present invention relates to an emulsion composition containing an effective ingredient at low pH and having improved stability,

The present disclosure relates to emulsified compositions comprising a cationic emollient, an anionic thickener, and an effective agent at low pH.

As a method of stabilizing the emulsion particles, there is a method of preventing the coalescence by making the emulsion layer firm with the surfactant, the parity alcohol and the acid. As a method of stabilizing the emulsion particle formed, there is a method of emulsion particle creaming (creaming), and a method of preventing flucculation are widely known.

In the O / W emulsified contents used as cosmetics to which such a stabilizing means is applied, the pH value is usually maintained at 5.5 to 7.5, but the efficacy substances (vitamin derivatives, ERP, etc.) In order to stabilize the formulation at low pH, nonionic surfactants or thickeners should be used. In this case, the stability of the contents (creaming / unification) is maintained There is an unacceptable problem.

In order to prevent this, conventionally, a method of maintaining stability by using an excess amount of an increasing agent and a nonionic surfactant has been mainly used. However, when the stability is maintained by such a method, skin irritation and trouble, bad feeling of use, excessive amount of unnecessary raw materials And the like.

From the viewpoint of one aspect, a problem to be solved by the present invention is to provide an emulsified composition excellent in emulsion stability.

Another aspect of the present invention is to provide an emulsified composition which is excellent in emulsion stability without pH control of a low pH effect agent.

From another point of view, a problem to be solved by the present invention is to provide an emulsified composition which is excellent in emulsion stability without using excessive amounts of an aging agent and a nonionic surfactant.

In view of solving such a problem, an emulsion composition comprising an oil phase comprising a cationic emollient, an aqueous phase comprising an anionic thickener, and an efficacy agent present on the oil phase or water, An emulsifying composition can be provided.

In one aspect, the present invention may relate to an emulsion composition having excellent emulsion stability.

In another aspect, the present invention may relate to an emulsified composition having excellent emulsion stability of an efficent having a low pH.

Figure 1 shows the formulation stability immediately after mixing of the emulsified composition according to one embodiment of the present invention.
Figure 2 shows the formulation stability of the emulsified composition according to one embodiment of the present invention after 8 hours.

Hereinafter, embodiments of the present invention will be described in more detail. However, the techniques disclosed in the present application are not limited to the embodiments described herein but may be embodied in other forms. It should be understood, however, that the embodiments disclosed herein are provided so that this disclosure will be thorough and complete, and will fully convey the scope of the invention to those skilled in the art. It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit and scope of the invention.

In one aspect of the present invention, there is provided a method of purifying an oil-in-water emulsion comprising an oil phase comprising a cationic emollient; An aqueous phase comprising an anionic thickener; And an efficacious substance present in the oil phase or in the upper part of the water, wherein the emulsified composition provides an emulsified composition having a pH of 5.5 or less.

The emulsifying composition may include, for example, water-in-oil (W / O), water-in-oil (O / W), but not limited thereto.

Since the two phases of the emulsion composition have mutual dislocations, the interface is stabilized due to interactions between charges, so that the coagulation, fusion, or creaming of the emulsion particles in the emulsion composition can be prevented.

In one aspect, the emulsified composition may be in water (O / W) or water in water (W / O). Specifically, the emulsified composition may be a water-in-oil type.

In one aspect of the invention, the composition may comprise an efficacious agent.

In one aspect, the effector is selected from the group consisting of ETHYL ASCORBIC ACID, ASCORBIC ACID, TRISODIUM FRUCTOSE DIPHOSPHATE, EPIGALLOCATECHIN GALLET, Catechin (EPIGALLOCATECHIN), epicatechin (EPICATECHIN), but is not limited thereto.

In one aspect, the potentiator may be pH 4 or lower, for example pH 2 to 4.

Specifically, the pH of the efficacious substance may be at least 2, at least 2.2, at least 2.4, at least 2.6, at least 2.8, at least 3.0, at least 3.2, at least 3.4, at least 3.6, or at least 3.8, , 3.4 or less, 3.2 or less, 3.0 or less, 2.8 or less, 2.6 or less, 2.4 or less, or 2.2 or less.

In one aspect, the emulsified composition may be pH 5.5 or lower, for example, pH 4 or lower. Specifically, the pH range of the emulsified composition may be 3 to 5.5. Even when the pH of the emulsified composition is in the range of 3 to 5.5 and the pH is low, the emulsified composition according to the present invention may have excellent emulsion stability.

Specifically, the pH of the emulsified composition may be at least 3, at least 3.2, at least 3.4, at least 3.6, at least 3.8, at least 4.0, at least 4.2, at least 4.4, at least 4.6, at least 4.8, at least 5.0, at least 5.2, , Less than 5.5, less than 5.4, less than 5.2, less than 5.0, less than 4.8, less than 4.6, less than 4.4, less than 4.2, less than 4.0, less than 3.8, less than 3.6, less than 3.4, less than 3.2.

Generally, when the pH is low, the composition having an underwater type (O / W) or a water-in-oil type (W / O) has poor stability. In particular, the stability of the composition, which is in the form of a water-in-oil type, may be more disadvantageous. Particularly, creaming or flucculation phenomenon occurs and it may be difficult to function as a product.

In one aspect, the emulsifying composition may comprise 0.01% to 20% by weight based on the total weight of the composition. Preferably from 0.01% to 5% by weight. When the active material is contained in the range of 0.01 to 20% by weight, the emulsion stability of the composition may be excellent.

More specifically, the efficacious substance may be used in an amount of 0.01 wt% or more, 0.1 wt% or more, 1 wt% or more, 2 wt% or more, 3 wt% or more, 4 wt% or more, 5 wt% or more, , At least 7 wt%, at least 8 wt%, at least 9 wt%, at least 10 wt%, at least 11 wt%, at least 12 wt%, at least 13 wt%, at least 14 wt%, or at least 15 wt% Up to 20 weight percent, up to 19 weight percent, up to 18 weight percent, up to 17 weight percent, up to 16 weight percent, up to 15 weight percent, up to 14 weight percent, up to 13 weight percent, up to 12 weight percent and up to 11 weight percent Or less, 10 wt% or less, 9 wt% or less, 8 wt% or less, 7 wt% or less, 6 wt% or less, or 5 wt% or less.

In one aspect of the invention, the composition may comprise a cationic emollient.

Since the composition comprises a material having opposite electric potentials in two phases, the two phases exhibit opposite electric potential and exhibit charge interactions at the interface between the two phases.

The cationic emollient may be any cationic material, but may include, for example, a cationic emollient, and may include, for example, a compound containing an amine group.

In one embodiment, the cationic emollient may have a weak agonist activity while forming a positive potential within a low pH, for example below pH 5, or below pH 4.

In one aspect of the present invention, the cationic emollient may include at least one selected from an aliphatic amine compound, an aromatic amine compound, and an amine group-containing silicone compound.

The compound containing an amine group may be, for example, a compound having a functional group such as -N═, -NH-, -NH 2, or the like. For example, a compound having a functional group such as an aliphatic amine compound, an aromatic amine compound, But are not limited to, species. For example, the compound containing an amine group may be an alkylamine containing a linear or branched alkyl group having 6 to 30 carbon atoms, an aliphatic amine compound such as an alkanolamine containing a linear or branched alkanol group having 6 to 30 carbon atoms, , aromatic amine compounds such as o-toluidine, 2,4,6-trimethylaniline, anisidine and N-methylaniline, bisamodimethicone, amodimethicone, aminopropyldimethicone ( aminopropyl dimethicone), and the like. For example, one selected from the group consisting of Hexyldecyl Myristoyl Methylaminopropionate, Bis amodimethicone, amodimethicone, and aminopropyl dimethicone. It can be more than a species.

In one aspect of the present invention, the emulsified composition may contain the cationic emollient in an amount of 0.01% to 50% by weight based on the total weight of the composition. , Preferably from 0.1% to 10% by weight. When the cationic emollient is contained in an amount of 0.01 to 50% by weight, the emulsion stability of the composition may be excellent.

More specifically, it is preferable to use an aqueous solution containing at least 1% by weight, at least 2% by weight, at least 4% by weight, at least 6% by weight, at least 8% by weight, at least 10% by weight, at least 12% by weight, at least 14% by weight, % Or more, 20 wt% or more, 22 wt% or more, 24 wt% or more, 26 wt% or more, 28 wt% or more, 30 wt% or more, 32 wt% or more, 34 wt% or more, 36 wt% or more, 38 wt% Or more, or 40 wt% or more, and 50 wt% or less, 48 wt% or less, 46 wt% or less, 44 wt% or less, 42 wt% or less, 40 wt% or less, 38 wt% or less, 36 Not more than 34 wt%, not more than 32 wt%, not more than 30 wt%, not more than 28 wt%, not more than 26 wt%, not more than 24 wt%, not more than 22 wt%, not more than 20 wt%, not more than 18 wt% By weight or less, 14% by weight or less, or 12% by weight or less.

In one aspect of the invention, the composition may comprise an anionic thickener.

The anionic thickener may be selected from the group consisting of a carbomer, a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and an acrylate / C10-30 alkyl acrylate crosspolymer ACRYLATES / C10-30 ALKYL ACRYLATE CROSSPOLYMER).

The anionic thickener may include, for example, an anionic polymer compound.

The anionic polymer compound may be, for example, a polymer compound having a carboxylic acid group, a sulfonic acid group, a sulfuric acid ester group, or a phosphoric acid ester group as a functional group. For example, it may be selected from an acrylic acid polymer, a polysaccharide polymer and a sulfonic polymer But is not limited thereto. For example, the anionic polymer compound may be selected from the group consisting of polyacrylic acid, polymethacrylic acid, polymethylmethacrylic acid, methylmethacrylate-acrylic acid copolymer, vinylpyrrolidone-acrylic acid copolymer, hydroxyethyl acrylate / sodium acrylate An acrylic acid polymer such as a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, an acrylate / C10-30 alkyl acrylate cross polymer (ACRYLATES / C10-30 ALKYL ACRYLATE CROSSPOLYMER), a carbomer, Polysaccharide polymer compounds such as alginic acid, pectin and polygalacturonic acid, and sulfonic acid-based polymer compounds such as polystyrene sulfonic acid. For example, hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, acrylate / C10-30 alkyl acrylate crosspolymer (ACRYLATES / C10-30 ALKYL ACRYLATE CROSSPOLYMER), acrylate / And carbomers may be used.

Generally, the thickening agent can be significantly reduced at low pH, for example below pH 5, or below pH 4.

In one aspect, when an anionic thickening agent is further added to the external phase in the emulsion composition according to the present invention, a thin film is formed between the particles due to charge interactions and the emulsion particles are wrapped. Thereby helping to maintain emulsion stability of the composition at low pH.

In one aspect of the present invention, the emulsifying composition may include 0.001 wt% to 10 wt% of the anionic thickener based on the total weight of the composition. Preferably 0.1% by weight to 1% by weight. When the anionic thickener is contained in an amount of 0.001 to 10% by weight, the emulsion stability of the composition may be excellent.

More specifically, it is preferable that the amount of the organic peroxide is 0.005 wt% or more, 0.01 wt% or more, 0.02 wt% or more, 0.03 wt% or more, 0.04 wt% or more, 0.05 wt% or more, 0.06 wt% or more, 0.07 wt% or more, At least 0.1% by weight, at least 0.12% by weight, at least 0.14% by weight, at least 0.16% by weight, at least 0.18% by weight, at least 0.2% by weight, at least 0.3% by weight, at least 0.4% by weight, at least 0.5% At least 0.7% by weight, at least 0.8% by weight, at least 0.9% by weight, at least 1.0% by weight, at least 1.5% by weight, at least 2.0% by weight, at least 2.5% by weight, at least 3.0% by weight, at least 4.0% %, 9 wt% or less, 8 wt% or less, 7 wt% or less, 6 wt% or less, 5 wt% or less, 4 wt% or less, 3 wt% or less, 2.5 wt% or less, Not more than 2.0 wt%, not more than 1.5 wt%, not more than 1.0 wt%, not more than 0.9 wt%, not more than 0.8 wt%, not more than 0.7 wt%, not more than 0.6 wt%, not more than 0.5 wt% Not more than 0.1% by weight, not more than 0.1% by weight, not more than 0.1% by weight, not more than 0.08% by weight, not more than 0.06% by weight, not more than 0.04% by weight %, 0.02 wt% or less, or 0.01 wt% or less.

In one aspect of the present invention, the viscosity of the composition may be 10-100,000 cps. When the composition has a viscosity of 10 - 100,000 cps, the emulsion stability of the composition may be excellent.

More than 100 cps, more than 1000 cps, more than 2000 cps, more than 3000 cps, more than 4000 cps, more than 5000 cps, more than 6000 cps, more than 7000 cps, more than 8000 cps, more than 9000 cps, more than 100000 cps, more than 15000 cps , At least 20000 cps, at least 250000 cps, at least 30000 cps, at least 350000 cps, at least 40000 cps, at least 45000 cps, at least 50000 cps, at least 55000 cps, at least 60000 cps, at least 65000 cps, at least 70000 cps, at least 75000 cps, cps or more, 85000 cps or more, 90000 cps or 95000 cps or more and may be 95000 cps or less, 90000 cps or less, 85000 cps or less, 80000 cps or less, 75000 cps or less, 70000 cps or less, 65000 cps or less, Not more than 55000 cps, not more than 50000 cps, not more than 45000 cps, not more than 40000 cps, less than 35000 cps, less than 30000 cps, less than 25000 cps, less than 20,000 cps, less than 15000 cps, less than 10,000 cps, less than 9000 cps, less than 8000 cps, Less than 6000 cps, less than 5000 cps, less than 4000 cps, less than 3000 cps, less than 2000 cps, less than 1000 c ps or less, or 100 cps or less.

In one embodiment, the composition may further comprise a surfactant for emulsification. Examples of the surfactant include lauryl PEG-9 polydimethylsiloxyethyl dimethicone, cyclopentasiloxane * PEG-10, and the like. Examples of the surfactant include, but are not limited to, Dimethicone * Distearimonium Hectorite, Cetyl PEG.PPG-10/1 Dimethicone (Cetyl Dimethicone Copolyol; Cetyl PEG.PPG-10/1 Dimethicone (Cetyl Dimethicone * Copolyol, etc.), arachidyl alcohol / behenyl alcohol / arachidyl glucoside (ARACHIDYL ALCOHOL / BEHENYL ALCOHOL / ARACHIDYL GLUCOSIDE), cetearyl alcohol * CETEARYL ALCOHOL * CETEARYL GLUCOSIDE), C14-22 alcohol * C12-20 alkyl glucoside (C14-22 ALCOHOLS * C12-20 ALKYL GLUCOSIDE), glyceryl stearate * PEG-100 stearate (Glyceryl Stearate * PEG- W You The like of a surfactant used, but is not limited thereto. The surfactant may be included in an amount of 0.001 to 10% by weight, for example, 0.01 to 1% by weight or 0.1 to 1% by weight based on the total weight of the composition. Within this range, the emulsion stability of the composition may be excellent. In this embodiment, it is possible to stabilize the emulsified formulation while containing a small amount of surfactant.

The composition according to embodiments of the present invention may be a cosmetic composition. The cosmetic composition may be formulated containing a cosmetically or dermatologically acceptable medium or base. It may be in the form of a suspension, a microemulsion, a microcapsule, a microgranule or an ionic (liposome) and a non-ionic follicular dispersion, or a cream, a skin, a lotion, a powder, an ointment, a spray, May be provided in the form of a stick. It can also be used in the form of a foam or in the form of an aerosol composition further containing a compressed propellant. These compositions may be prepared according to conventional methods in the art.

In addition, the cosmetic composition according to embodiments of the present invention may be in the form of powders, fatty substances, organic solvents, solubilizers, thickeners, gelling agents, softeners, antioxidants, suspending agents, stabilizers, foaming agents, , Water, ionic or nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, barrier agents, wetting agents, essential oils, dyes, pigments, hydrophilic or lipophilic active agents, lipid vesicles or cosmetics And any other ingredients used, such as cosmetics or adjuvants commonly used in the field of dermatology. Such adjuvants are introduced in amounts commonly used in the cosmetics or dermatological fields. The cosmetic composition according to the embodiments of the present invention may further contain a skin absorption promoting substance to increase the skin improving effect.

Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are merely illustrative of the present invention and that the scope of the present invention is not construed as being limited by these embodiments.

[Preparation Example 1] Preparation of emulsified composition

The oil was purchased from AMYRIS, the most commonly used material, NEOSSANCE SQUALANE (SQUALANE), and the cationic emollient was purchased under the trade name AMITER MA-HD, hexyldecyl myristate HEXYLDECYL MYRISTOYL METHYL AMINOPROPIONATE was purchased from Nippon Emulsion Co., and an anionic thickener was used as a carbomer and ETHYL ASCORBIC ACID was used as an efficacy substance.

Experiments were carried out by mixing each component in the amounts shown in Table 1, titrating to the corresponding pH, and hand mixing.

ingredient Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Example 1 Example 2 SQUALENE 20 20 20 - - - HEXYLDECYL MYRISTOYL METHYLAMINOPROPIONATE - - - 20 20 20 ETHYL ASCORBIC ACID 0 5 5 0 5 5 PH of efficacious substance 3 ± 0.5 3 ± 0.5 3 ± 0.5 3 ± 0.5 3 ± 0.5 3 ± 0.5 Water To 100 To 100 To 100 To 100 To 100 To 100 Carbomer 0 0 0.1 0 0 0.1 total 100 100 100 100 100 100 The pH of the emulsified composition 6 ± 0.5 3 ± 0.5 3 ± 0.5 6 ± 0.5 3 ± 0.5 3 ± 0.5 Separation phenomenon Immediately
detach Immediately
detach slowly
detach Immediate separation Not easy to separate Gel formation in the middle.
Isolation better

[Experimental Example 1] Confirmation of formulation stability

The emulsion composition of Preparation Example 1 was allowed to stand at room temperature for 8 hours and the formulation was observed. In Comparative Examples 1 to 4 (samples 1 to 4 in Figs. 1 and 2), it was confirmed that the water and the cationic material were separated immediately or within 8 hours. This can be confirmed from FIG. 2, which is a comparative drawing showing the stability after 8 hours.

In particular, in Comparative Example 4, the pH of the composition was maintained at pH 6 ± 0.5 by adjusting the pH of the composition. For this reason, even though the cationic emollient hexyldecyl myristoyl methyl aminopropionate was contained, . Example 1 (sample No. 5 in FIG. 1 and FIG. 2) showed a pH drop of about 3 when ethyl ascorbic acid (ETHYL ASCORBIC ACID) was added. Partial emulsification was observed by hand mixing and separation took place very slowly after more than 8 hours (see FIG. 2). Example 2 (sample No. 6 in Fig. 1) is the contents containing an efficacious substance and an anionic thickener carbomer. It was observed that not only a certain portion was emulsified by hand mixing, but also a gel was formed. The separation took place more slowly than in Example 1, and the formulation was maintained without separation even after a lapse of 8 hours or more (see FIG. 2). Particularly, it was confirmed that the gel was hardly separated from the portion where the gel was formed.

Accordingly, the emulsifying composition according to the present invention has excellent formulation stability while containing a low-pH effect agent.

Claims (11)

An oily phase comprising a cationic emollient;
An aqueous phase comprising an anionic thickener; And
An efficacious substance present in the oily phase or in the upper part of the water,
Wherein the emulsified composition has a pH of 5.5 or less. The method according to claim 1,
Wherein the emulsion composition is of the aqueous type (O / W). The method according to claim 1,
The efficacious substance is selected from the group consisting of ETHYL ASCORBIC ACID, ASCORBIC ACID, TRISODIUM FRUCTOSE DIPHOSPHATE, EPIGALLOCATECHIN GALLETE, EPIGALLOCATEECHIN, , Epicatechin (EPICATECHIN). The method according to claim 1,
Wherein the emulsified composition has a pH of 4 or less. The method according to claim 1,
Wherein the emulsifying composition comprises 0.01% to 20% by weight based on the total weight of the composition. The method according to claim 1,
Wherein the cationic emollient comprises at least one selected from an aliphatic amine compound, an aromatic amine compound and an amine group-containing silicone compound. The method according to claim 1,
The cationic emollient is selected from among hexyldecyl myristoyl methylaminopropionate, bis amodimethicone, amodimethicone, and aminopropyl dimethicone. ≪ / RTI > by weight of the composition. The method according to claim 1,
Wherein the composition comprises from 0.01% to 50% by weight of the cationic emollient, based on the total weight of the composition. The method according to claim 1,
The anionic thickener may be selected from the group consisting of a carbomer, a hydroxyethyl acrylate / sodium acryloyldimethyl taurate copolymer, and an acrylate / C10-30 alkyl acrylate crosspolymer ACRYLATES / C10-30 ALKYL ACRYLATE CROSSPOLYMER). The method according to claim 1,
Wherein the composition comprises from 0.001% to 10% by weight of the anionic thickener relative to the total weight of the composition. The method according to claim 1,
Wherein the composition has a viscosity of from 10 to 100,000 cps.

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