KR102253134B1 - Cosmetic composition for protecting microdust - Google Patents

Abstract

The present invention relates to a cosmetic composition for blocking fine dust. By using the composition according to the present invention, it is possible to prevent problems caused by fine dust at the source by lowering the adhesion rate at which fine dust adheres to the skin.

Description

Cosmetic composition for protecting microdust}

The present invention relates to a cosmetic composition for blocking fine dust.

In modern society, automobile emissions in urban areas and industrial parks, yellow dust flying through industrial zones in eastern China, or fine dust including external pollutants can cause skin aging and skin troubles.

Since the size of the fine dust is mostly 10 μm or less, it is much smaller than that of general dust (average size is 50 μm or more) (US Environmental Protection Agency (EPA)). According to the research results of the National Institute of Environmental Sciences (2006), the major components of fine dust in the metropolitan area are sulfates, nitrates, and secondary products from China. Fine dust penetrates deep into the alveoli of a person and accumulates in the bronchi and lungs, causing a direct cause of various respiratory diseases, lowering the body's immune function, causing asthma and shortness of breath. It can also increase. Because the size of fine dust in the skin is small, it can easily penetrate deep into the pores. Failure to cleanly remove the infiltrated fine dust often causes inflammation and troubles in the skin, so it is important to block the fine dust in advance so that it cannot penetrate the skin.

As a technology for blocking fine dust in the related art, it is a technology that uses the repulsive force of the same charge and blocks fine dust, which is a negatively charged raw material in the formulation, or forms a network on the skin surface to prevent the penetration of fine dust into pores. It is disclosed. However, in reality, fine dust can have a positive charge as well as a negative charge, and the effect of blocking fine dust with the repulsive force of a specific charge is very insignificant, and the film-forming polymer cannot fundamentally prevent the adhesion of fine dust to the skin surface. There is this.

Fine dust can be removed to some extent with cleansing, but it is impossible to completely remove fine dust that has penetrated deep into the pores with regular cleansing because the more fine it is, the stronger the adsorption power is, so it is fundamentally blocked so that fine dust does not adhere to the skin. You need the skill to do it.

Republic of Korea Patent Publication No. 10-2016-0000959

The problem to be solved by the present invention is to provide a composition for blocking fine dust that prevents problems caused by fine dust by lowering the amount of fine dust attached to the skin.

In order to solve the above problems, the present invention provides a composition for blocking fine dust, preferably a cosmetic composition, comprising a compound containing an N-hetero ring as an active ingredient.

As a solution to conventional fine dust, a method of cleansing and removing fine dust adhered to the skin, blocking fine dust using negative charge repulsion, and forming a network on the skin surface were used. However, in the method of cleansing the fine dust attached to the skin, the fine dust may have already attached to the skin, causing problems on the skin, and the very fine dust has a strong adsorption power, so if it has already been adsorbed to the skin, cleansing may be difficult. In addition, the method of blocking fine dust using negative charge repulsion has insufficient actual fine dust blocking effect because fine dust can have a negative charge as well as a positive charge, and the method of forming a network on the skin surface requires that fine dust adhere to the skin surface. There was a problem that it could not be prevented. Accordingly, the present inventors have studied a component that is included in the cosmetic composition to block the adhesion of fine dust to the skin, and experimentally confirmed that if a compound containing an N-hetero ring is included, the adhesion of fine dust to the skin can be significantly reduced Thus, the present invention was completed.

The term "fine dust" used in the present invention means a fine dust having a size of 10 μm or less. The dust is not limited to a specific component, and includes all substances commonly referred to as dust.

As used herein, the term "fine dust blocking" means preventing the fine dust from adhering to the skin, and broadly includes removing fine dust attached to the skin.

The present inventors experimentally confirmed that the adhesion of fine dust to the skin is prevented by using a composition containing a compound containing an N-heterocycle according to the present invention as an active ingredient.

As used herein, the term "a compound containing an N-hetero ring" refers to a compound containing a hetero ring containing a nitrogen atom as a hetero atom.

Preferably, the N-hetero ring is a saturated or unsaturated 5, 6 or 9 membered N-hetero ring. Examples of the five-membered N-hetero ring include, but are not limited to, pyrrolidine, pyrroline, pyrrole, pyrazolidine, imidazolidine, pyrazoline, imidazoline, pyrazole, imidazole, triazole, tetra Sol, oxazole, thiazole, oxadiazole, thiadiazole, and the like, and thus the five-membered N-hetero ring is pyrrolidine, pyrroline, pyrrole, pyrazolidine, imidazolidine, pyrazoline, imidazole It may be any one or more selected from the group consisting of dazoline, pyrazole, imidazole, triazole, tetrazole, oxazole, thiazole, oxadiazole, and thiadiazole. Examples of 6-membered N-heterocycles include, but are not limited to, piperidine, piperazine, pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiomorpholine, thiazine, cytosine, thymine, Uracil, thiophosphorine dioxide, etc., and thus the 6-membered N-hetero ring is piperidine, piperazine, pyridine, pyridazine, pyrimidine, pyrazine, triazine, oxazine, thiomorpholine, thiazine, cyto It may be any one or more selected from the group consisting of sin, thymine, uracil and thioporin dioxide.

In addition, in a preferred embodiment of the present invention, the present inventors use a composition containing as an active ingredient a compound containing a 9-membered N-hetero ring in which a 5-membered N-hetero ring is bonded to a benzene ring. It was experimentally confirmed that it prevents the adhesion of fine dust.

Examples of the 9-membered N-hetero ring include, but are not limited to, indoline, indole, isoindole, indazole, benzimidazole, azaindole, etc. Therefore, the 9-membered N-hetero ring is indoline, indole , Isoindole, indazole, benzimidazole and azaindole may be any one or more selected from the group consisting of.

More preferably, in order to achieve the object of the present invention, the N-hetero ring may be a 6-membered N-hetero ring or a 9-membered N-hetero ring, and even more preferably triazine, benzotriazole, and benzimidazole It may be any one or more selected from the group consisting of.

Most preferably, the compound containing the N-hetero ring is bis-ethylhexyloxyphenol methoxyphenyl triazine (bis-ethylhexyloxyphenol methoxyphenyl triazine), melamine (1,3,5-triazine-2,4,6 -triamine), methylenebis-benzotriazolyltetramethylbutylphenol, ethylhexyltriazone, phenylbenzimidazolesulphonic acid, diethylhexylbutamidotriazone, disodiumphenyldibenzimidazoletetrasulfonate, dromet It may be resoltrisiloxane, or trisbiphenyl triazine. The present inventors experimentally confirmed that it is possible to significantly reduce the adhesion of fine dust to the skin by preparing a cosmetic composition containing the above substances.

Compounds containing an N-hetero ring can block fine dust by neutralizing a fine charge existing on the surface of the skin or an object, and the theory is not limited thereto.

In addition, the compound containing the N-hetero ring of the present invention has an effect of preventing or blocking the adhesion of heavy metals.

Preferably, the molecular weight of the compound containing the N-hetero ring may be 100 to 1,000, more preferably 200 to 800, and even more preferably 300 to 700.

In the present invention, the compound containing the N-hetero ring may be contained in an amount of 0.1 to 10% by weight, preferably 0.5 to 8% by weight, and more preferably 1 to 5% by weight based on the total weight of the composition. have. When it exceeds 10% by weight, the feeling of use of the formulation may be sticky, oily, and greasy, and the stability of the formulation may be deteriorated.

In addition, the cosmetic composition for blocking fine dust according to the present invention is a moisturizing agent, thickener, powder, alcohol, natural polymer, synthetic polymer, sugar, antioxidant, buffering agent, various extracts within the scope of not impairing the effects of the present invention in addition to the above active ingredients. , A stabilizer, a preservative, a colorant, or a flavoring agent, or the like, may be suitably blended and prepared according to a conventional method. The moisturizing agent may be glycerin, sorbitol, butylene glycol, dipropylene glycol, propylene glycol, pentylene glycol, propanediol, 1,2-hexanediol, octanediol, or extracts derived from natural products, which are commonly used in cosmetics. .

Including the remaining amount of water.

In addition, the cosmetic composition for blocking fine dust according to the present invention is a solution, external ointment, cream, foam, nutrient lotion, softening lotion, softening water, emulsion, makeup base, essence, liquid cleaning agent, bathing agent, sunscreen cream, sun oil, Suspensions, emulsions, pastes, gels, lotions, powders, oils, powder foundations, emulsion foundations, wax foundations, patches, mists, sprays, etc. may be prepared in a formulation selected from the group consisting of, but is not limited thereto.

In one embodiment of the present invention, the compound containing the N-hetero ring may be contained in an oil-dispersed form. This refers to a form in which oils are added to dissolve the compound according to the general characteristics of a compound containing an N-hetero ring.

In this case, the cosmetic composition of the present invention may have an emulsified formulation, and may further include an oil, preferably a polar oil and/or a silicone oil for dissolution of the compound containing an N-hetero ring, and is limited thereto. For example, but not dicaprylyl carbonate, caprylic/capric triglyceride, isopropyl palmitate, C12-15 alkylbenzoate, propylheptylcaprylate, coco-caprylate/caprate, dibutyladi These include pate, triethylhexanoin, phenyltrimethicone, cyclopentasiloxane, cyclohexasiloxane, and caprylyltrimethicone. That is, the cosmetic composition according to the present invention can be prepared by dissolving a compound containing an N-hetero ring in an oil (or oil phase).

In another embodiment of the present invention, the compound containing the N-hetero ring may be contained in an aqueous dispersion.

In general, compounds containing N-hetero rings are oil-soluble, so oils should be prescribed for dispersion, but in the case of the present invention, compounds containing N-hetero rings can be dispersed in an aqueous phase without oil prescriptions, so that N-hetero rings are included. At the same time, it provides a cosmetic composition that is a hydration formulation.

The hydration formulation may be a formulation selected from the group consisting of water gel, solution, foam, lotion, emulsion, suspension, emulsion, paste, lotion, patch, mist, and spray formulation, but is not limited thereto.

As such, the compound containing the N-hetero ring may be mixed and treated with other compounds to improve solubility or dispersibility in water. If the dispersibility in water is excellent, it can be easily used in a cosmetic composition containing a large amount of water, and it is possible to minimize or eliminate the content of oil in the composition.

In the aqueous dispersion form of the compound containing the N-hetero ring, it is possible to purchase and use commercially available raw materials, for example, it is also possible to purchase and use raw materials from BASF (trade name: Tinosorb® S Aqua). Do.

By using the composition according to the present invention, it is possible to prevent problems caused by fine dust at the source by lowering the adhesion rate at which fine dust adheres to the skin.

Hereinafter, examples and examples will be described in detail to describe the present invention in detail. However, the embodiments and examples according to the present invention may be modified in various other forms, and the scope of the present invention should not be construed as being limited to the embodiments and examples described below. Examples and examples of the present invention are provided to more completely describe the present invention to those of ordinary skill in the art.

Experimental Example 1: Preparation of Example 1 and Comparative Examples 1-3 and evaluation of adhesion of fine dust

The present inventors prepared an essence having the composition shown in Table 1 below by a conventional method for an evaluation experiment for adhesion of fine dust.

Raw material Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Content (% by weight) Content (% by weight) Content (% by weight) Content (% by weight) Purified water To 100 To 100 To 100 To 100 glycerin 3 3 3 3 Butylene glycol 6 6 6 6 1,2-hexanediol 1.5 1.5 1.5 1.5 Stearic acid 0.3 0.3 0.3 0.3 Cetearyl glucoside 0.2 0.2 0.2 0.2 Cetearyl alcohol 0.8 0.8 0.8 0.8 Methyl glucose sesquistearate One One One One Glyceryl stearate 0.5 0.5 0.5 0.5 Phenyltrimethicone 4 4 4 4 Cyclopentasiloxane 4 4 4 4 Cyclohexasiloxane 2 2 2 2 Bis-ethylhexyloxyphenol methoxyphenyl triazine ⁽¹⁾ 2.0 - - - Arachidyl Glucoside - 2.0 - - Isostearyl isostearate - - 2.0 - Spices 0.1 0.1 0.1 0.1

⁽¹⁾ Tinosorb ^® S, BASF

1) How to evaluate fine dust adhesion

i) After applying 1.3 mg/cm ² of artificial sebum to the PMMA plate, it was dried for 15 minutes.

ii) The test formulation was applied to the dried artificial sebum in the same amount and dried for 15 minutes (no control was applied).

iii) 0.5 g of alternative fine dust by attaching the PMMA plate to the top of the internal chamber and running the fan at the bottom of the chamber for 5 minutes (brand name LM-YG0510, strontium carbonate, alumina, europium oxide, dysprosium oxide) Was exposed for 5 minutes.

iv) UV images were taken using a magnifying glass (Aphrodite-3, 50x) (measured at 4 points per plate).

v) The dust adhesion area was calculated using ImagePro Plus.

vi) As a result of the three experiments, the samples were compared to calculate the fine dust adhesion rate (the fine dust adhesion rate of the control group was set to 100).

2) result

As a result, as shown in Table 2, Example 1 exhibited a relative adhesion rate of less than 1/3 compared to the control group, and excellent anti-fine dust adhesion prevention effect to show a relative adhesion rate of less than 1/2 compared to Comparative Examples 1-3. It was confirmed that there was.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Control Fine dust adhesion rate (%) 28.97 88.31 89.85 63.90 100

Experimental Example 2: Preparation of Example 2 and Comparative Examples 4 to 8 and evaluation of adhesion of fine dust

The present inventors prepared an essence having the composition of Table 3 below by a conventional method for the evaluation of fine dust adhesion.

Raw material Example 2 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 content
(weight%) content
(weight%) content
(weight%) content
(weight%) content
(weight%) content
(weight%) Purified water To 100 To 100 To 100 To 100 To 100 To 100 glycerin 3 3 3 3 3 3 Butylene glycol 6 6 6 6 6 6 1,2-hexanediol 1.5 1.5 1.5 1.5 1.5 1.5 Stearic acid 0.3 0.3 0.3 0.3 0.3 0.3 Cetearyl glucoside 0.2 0.2 0.2 0.2 0.2 0.2 Cetearyl alcohol 0.8 0.8 0.8 0.8 0.8 0.8 Bis-ethylhexyloxyphenol methoxyphenyltriazine aqueous dispersion ⁽²⁾ 0.5 - - - - - Amodimethicone - 0.5 - - - - Polyquaternium-10 - - 0.5 - - - Polymethyl methacrylate - - - 0.5 - - Aminomethylpropanol - - - - 0.5 - Spices 0.1 0.1 0.1 0.1 0.1 0.1

⁽²⁾ Tinosorb ^® S Aqua, BASF

As a result, as shown in Table 4, Example 2 exhibited a relative adhesion rate of about 1/4 compared to the control group, and excellent anti-fine dust adhesion prevention effect to show a relative adhesion rate of less than 1/3 compared to Comparative Examples 4-8. It was confirmed that there was.

In addition, the effect of preventing the adhesion of fine dust of the remaining compounds contained in the aqueous dispersion of bis-ethylhexyloxyphenol methoxyphenyltriazine of Example 2 (Tinosorb ^{® S Aqua, BASF) was confirmed through Comparative Examples 6 and 7} It was confirmed that the remaining compounds except for ethylhexyloxyphenol methoxyphenyl triazine had no effect of preventing fine dust adhesion.

Example 2 Comparative Example 4 Comparative Example 5 Comparative Example 6 Comparative Example 7 Comparative Example 8 Control Fine dust adhesion rate (%) 25.21 89.66 91.10 92.52 80.77 77.68 100

Experimental Example 3: Preparation of Example 3 and Comparative Example 9 and evaluation of fine dust adhesion

The present inventors prepared the water gel formulations of Example 3 and Comparative Example 9 with the contents shown in Table 5 below, and evaluated the adhesion of fine dust.

Example 3 Comparative Example 9 Raw material INCI name Content (% by weight) Content (% by weight) Purified water To 100 To 100 glycerin 4 4 PEG-5 2 2 1,2-hexanediol One One Ammonium Acryloyl Dimethyl Taurate/VP Copolymer 0.4 0.4 Melamine 0.5 -

As a result, as shown in Table 6, compared to the control group to which nothing was applied, Comparative Example 9 had no effect of preventing adhesion of fine dust at all, but rather fine dust adhered better, but Example 3 was less than 85% compared to the control group, Comparative Example 9 It was confirmed that the relative adhesion rate was less than 1/2 compared to that of the melamine (melamine, 1,3,5-triazine-2,4,6-triamine) characteristically contained in Example 3 to prevent adhesion of fine dust. Was confirmed.

Example 3 Comparative Example 9 Control Fine dust adhesion rate (%) 82.1 178.5 100

Experimental Example 4: Preparation of Examples 4-6 and Comparative Examples 10-12 and evaluation of fine dust adhesion

The present inventors prepared emulsion formulations of Examples 4-6 and Comparative Examples 10-12 with the contents shown in Table 7 below, and evaluated fine dust adhesion.

Example 4 Example 5 Example 6 Comparative Example 10 Comparative Example 11 Comparative Example 12 Raw material INCI name content
(weight%) content
(weight%) content
(weight%) content
(weight%) content
(weight%) content
(weight%) Hydrogenated Polydecene 3 3 3 3 3 3 Cyclopentasiloxane 5 5 5 5 5 5 Cetearyl alcohol 1.5 1.5 1.5 1.5 1.5 1.5 Ceteares-6 olivate 1.2 1.2 1.2 1.2 1.2 1.2 Shea butter 3 3 3 3 3 3 Isostearate One One One One One One Phenethylbenzoate 2 2 2 2 2 2 Purified water To 100 To 100 To 100 To 100 To 100 To 100 Xanthan gum 0.2 0.2 0.2 0.2 0.2 0.2 Acrylate/C10-30 alkyl acrylate crosspolymer 0.02 0.02 0.02 0.02 0.02 0.02 Hydrogenated Lecithin 0.5 0.5 0.5 0.5 0.5 0.5 Trisodium EDTA 0.02 0.02 0.02 0.02 0.02 0.02 Panthenol One One One One One One glycerin 5 5 5 5 5 5 Butylene glycol 3 3 3 3 3 3 1,2-hexanediol One One One One One One Thrommethamine 0.02 0.02 0.02 0.02 0.02 0.02 Spices 0.12 0.12 0.12 0.12 0.12 0.12 Methylenebis-benzotriazolyltetramethylbutylphenol 4 - - - - - Ethylhexyltriazone - 2 - - - - Phenylbenzimidazole Sulphonic Acid - - 2 - - - Ethylhexylmethoxycinnamate - - - - 6 - Ethylhexylsalicylate - - - - - 4.5

As a result, as shown in Table 8, there is a slight effect of preventing adhesion of fine dust even in Comparative Examples 10 to 12 compared to the control group to which nothing was applied, but Example 4 was less than 1/3 of the control group, and Example 5 was about the control group. 1/3 and Example 6 confirmed that the relative adhesion rate was less than 1/2 compared to the control group, and methylenebis-benzotriazolyltetramethylbutylphenol and ethylhexyl respectively characteristically contained in Examples 4, 5, and 6 The excellent effect of preventing adhesion of fine dust of triazone and phenylbenzimidazole sulfonic acid was confirmed.

Example 4 Example 5 Example 6 Comparative Example 10 Comparative Example 11 Comparative Example 12 Control Fine dust adhesion rate (%) 31.43 34.45 45.21 87.23 79.63 85.21 100

Methylenebis-benzotriazolyltetramethylbutylphenol with N-heterocyclic benzotriazole, ethylhexyltrizone with triazine, and phenylbenzimidazole sulphonic acid with benzimidazole compared to other compounds. It showed excellent fine dust adhesion reduction effect.

Experimental Example 5: Preparation of Examples 7-10 and Comparative Examples 13-15 and evaluation of fine dust adhesion

The present inventors prepared the cream formulations of Examples 7-10 and Comparative Examples 13-15 in the amounts shown in Table 9 below, and evaluated the adhesion of fine dust.

Example 7 Example 8 Example 9 Example 10 Comparative Example 13 Comparative Example 14 Comparative Example 15 Raw material INCI name content
(weight%) content
(weight%) content
(weight%) content
(weight%) content
(weight%) content
(weight%) content
(weight%) Cetearyl alcohol 2 2 2 2 2 2 2 Beeswax 2 2 2 2 2 2 2 Glyceryl stearate One One One One One One One PEG-100 Stearate One One One One One One One Sucrose polytearate 2 2 2 2 2 2 2 Triethylhexanoine 2 2 2 2 2 2 2 Dimethicone 5 5 5 5 5 5 5 Caprylyl Trimethicone 5 5 5 5 5 5 5 Purified water To 100 To 100 To 100 To 100 To 100 To 100 To 100 Acrylate/C10-30 alkyl acrylate crosspolymer 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Xanthan gum 0.1 0.1 0.1 0.1 0.1 0.1 0.1 Carbomer 0.2 0.2 0.2 0.2 0.2 0.2 0.2 Propanediol 3 3 3 3 3 3 3 glycerin 5 5 5 5 5 5 5 Butylene glycol 6 6 6 6 6 6 6 1,2-hexanediol One One One One One One One Thrommethamine 0.08 0.08 0.08 0.08 0.08 0.08 0.08 Spices 0.1 0.12 0.12 0.12 0.12 0.12 0.12 Diethylhexylbutamidotriazone 3 - - - - - - Disodium phenyl dibenzimidazole tetrasulfonate - 3 - - - - - Dromethrizoltrisiloxane - - 3 - - - - Trisbiphenyl triazine - - - 3 - - - Ethylhexylmethoxycinnamate - - - - - 6 - Ethylhexylsalicylate - - - - - - 4.5

As a result, as shown in Table 10, Comparative Examples 13-15 showed little effect of preventing adhesion of fine dust compared to the control group to which nothing was applied, and Examples 7-10 showed less than 1/2 of the relative adhesion compared to the control group. It was confirmed that the ratio was shown, and the characteristics of diethylhexylbutamidotriazone, disodiumphenyldibenzimidazoletetrasulfonate, dromethrizoltrisiloxane, and trisbiphenyl triazine each characteristically contained in Examples 7-10. The excellent effect of preventing adhesion of fine dust was confirmed.

Example 7 Example 8 Example 9 Example 10 Comparative Example 13 Comparative Example 14 Comparative Example 15 Control Fine dust adhesion rate (%) 42.55 39.69 45.81 40.07 98.12 91.45 88.87 100

Diethylhexylbutamidotriazone having an N-heterocyclic structure of triazine, disodiumphenyldibenzimidazole tetrasulfonate having benzimidazole, dromethrizoltrisiloxane having benzotriazole, and triazine The trisbiphenyl triazine possessed showed an excellent effect of reducing adhesion of fine dust compared to the other compounds.

Claims (12)

A cosmetic composition for blocking fine dust, comprising as an active ingredient a fine dust blocking agent composed of a compound containing an N-hetero ring,
The cosmetic composition, characterized in that the N-hetero ring is a saturated or unsaturated 9-membered N-hetero ring. delete delete delete The method of claim 1,
The 9-membered N-hetero ring is a cosmetic composition, characterized in that at least one selected from the group consisting of indoline, indole, isoindole, indazole, benzimidazole and azaindole. The method of claim 1,
The N-hetero ring is a cosmetic composition, characterized in that at least one selected from the group consisting of benzotriazole and benzimidazole. The method of claim 1,
A cosmetic composition, characterized in that the compound containing the N-hetero ring is contained in an aqueous dispersion. The cosmetic composition of claim 7, wherein the cosmetic composition does not contain an oil component. The cosmetic composition of claim 7, wherein the cosmetic composition is a hydration formulation. The cosmetic composition of claim 9, wherein the hydration formulation is a formulation selected from the group consisting of water gel, solution, foam, lotion, emulsion, suspension, emulsion, paste, lotion, patch, mist, and spray formulation. The method of claim 1,
Cosmetic composition, characterized in that the molecular weight of the compound containing the N-hetero ring is 100 to 1,000. The method of claim 1,
A cosmetic composition, characterized in that the compound containing the N-hetero ring is contained in an amount of 0.1 to 10% by weight based on the total weight of the composition.