KR20190032370A - 암을 치료하기 위한 복합 요법 - Google Patents

암을 치료하기 위한 복합 요법 Download PDF

Info

Publication number
KR20190032370A
KR20190032370A KR1020197001728A KR20197001728A KR20190032370A KR 20190032370 A KR20190032370 A KR 20190032370A KR 1020197001728 A KR1020197001728 A KR 1020197001728A KR 20197001728 A KR20197001728 A KR 20197001728A KR 20190032370 A KR20190032370 A KR 20190032370A
Authority
KR
South Korea
Prior art keywords
compound
formula
chemotherapeutic agent
leukemia
inv
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
KR1020197001728A
Other languages
English (en)
Korean (ko)
Inventor
존 에이치. 부시웰러
아누라다 일렌둘라
Original Assignee
유니버시티 오브 버지니아 페이턴트 파운데이션
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 유니버시티 오브 버지니아 페이턴트 파운데이션 filed Critical 유니버시티 오브 버지니아 페이턴트 파운데이션
Publication of KR20190032370A publication Critical patent/KR20190032370A/ko
Ceased legal-status Critical Current

Links

Images

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • A61P35/02Antineoplastic agents specific for leukemia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
KR1020197001728A 2016-07-27 2017-07-27 암을 치료하기 위한 복합 요법 Ceased KR20190032370A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662367263P 2016-07-27 2016-07-27
US62/367,263 2016-07-27
PCT/US2017/044124 WO2018022855A1 (en) 2016-07-27 2017-07-27 Combination therapies for treating cancer

Publications (1)

Publication Number Publication Date
KR20190032370A true KR20190032370A (ko) 2019-03-27

Family

ID=61016782

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1020197001728A Ceased KR20190032370A (ko) 2016-07-27 2017-07-27 암을 치료하기 위한 복합 요법

Country Status (13)

Country Link
US (1) US11241421B2 (https=)
EP (1) EP3490557B1 (https=)
JP (1) JP2019525924A (https=)
KR (1) KR20190032370A (https=)
CN (1) CN109475542A (https=)
AU (1) AU2017302330A1 (https=)
BR (1) BR112019000049A2 (https=)
CA (1) CA3028461A1 (https=)
EA (1) EA201990395A1 (https=)
IL (1) IL263942A (https=)
MX (1) MX2019000179A (https=)
WO (1) WO2018022855A1 (https=)
ZA (1) ZA201900438B (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2021525280A (ja) 2018-05-24 2021-09-24 ユニバーシティ オブ バージニア パテント ファウンデーション がんを治療するための併用療法
CN117567434A (zh) * 2022-08-08 2024-02-20 武汉大学 靶向CBFβ-SMMHC蛋白的PROTAC类化合物及其制备方法与应用

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5643935A (en) 1995-06-07 1997-07-01 The University Of North Carolina At Chapel Hill Method of combatting infectious diseases using dicationic bis-benzimidazoles
US6372719B1 (en) * 1998-03-04 2002-04-16 Jay Cunningham ανβ3 integrin antagonists in combination with chemotherapeutic agents
WO2006104668A2 (en) 2005-03-11 2006-10-05 Temple University - Of The Commonwealth System Of Higher Education Composition and methods for the treatment of proliferative diseases
CA2614324A1 (en) * 2005-07-06 2007-01-18 Kanisa Pharmaceuticals, Inc. Zosuquidar, daunorubicin, and cytarabine for the treatment of cancer
EP3670509B1 (en) * 2009-05-13 2023-04-19 University of Virginia Patent Foundation Inhibitors of inv(16) leukemia

Also Published As

Publication number Publication date
CN109475542A (zh) 2019-03-15
MX2019000179A (es) 2019-06-20
ZA201900438B (en) 2019-10-30
JP2019525924A (ja) 2019-09-12
EP3490557A1 (en) 2019-06-05
US11241421B2 (en) 2022-02-08
CA3028461A1 (en) 2018-02-01
AU2017302330A1 (en) 2019-01-17
US20190343820A1 (en) 2019-11-14
IL263942A (en) 2019-02-28
EA201990395A1 (ru) 2019-07-31
WO2018022855A1 (en) 2018-02-01
EP3490557B1 (en) 2022-09-07
EP3490557A4 (en) 2020-04-01
BR112019000049A2 (pt) 2019-04-02

Similar Documents

Publication Publication Date Title
US11413278B2 (en) Compounds and methods for promoting stress resistance
EP3349754B1 (en) Pcna inhibitors
KR102861339B1 (ko) 삼치환 벤조트리아졸 유도체의 사용 방법
EA024391B1 (ru) Производные бензамида для ингибирования активности abl1, abl2 и bcr-abl1
AU2018314236B2 (en) RNA aptamers against transferrin receptor (TfR)
WO2016025744A1 (en) Cancer therapeutics
US10428048B2 (en) Androgen receptor antagonists
WO2020132259A1 (en) Compositions and methods of treating cancers by administering a phenothiazine-related drug that activates protein phosphatase 2a (pp2a)
JP2020529418A (ja) T細胞急性リンパ芽球性白血病を治療するための化合物、組成及び方法
KR20190032370A (ko) 암을 치료하기 위한 복합 요법
KR20120134605A (ko) 1,2,3,4,6?펜타?오?갈로일?베타?디?글루코오스및 이마티니브를 유효성분으로 포함하는 만성 골수성 백혈병 치료용 조성물
WO2023131305A1 (zh) Prmt5抑制剂和抗癌治疗剂的组合
KR20190031291A (ko) BCL-2 억제제와 MCl-1 억제제의 조합물, 이의 용도 및 약학적 조성물
TWI753178B (zh) Mcl-1抑制劑與血液癌症標準療法之組合,其用途及醫藥組合物
HK40003583A (en) Combination therapies for treating cancer
Kim et al. Kappa-opioid receptor activation during reperfusion limits myocardial infarction via ERK1/2 activation in isolated rat hearts
WO2018187509A1 (en) Heterocyclic compounds as chemokine receptor modulators
US20230165873A1 (en) Methods of Use for Single Molecule Compounds Providing Multi-Target Inhibition to Treat Covid 19
RU2328306C2 (ru) Комбинированная противоопухолевая терапия замещенными производными акрилоилдистамицина и ингибиторами протеинкиназ (серин-/треонинкиназы)
US11717511B2 (en) Pharmaceutical composition comprising derivative compound of 1,2-naphthoquinone for preventing or treating solid cancer or blood cancer
US10196378B2 (en) Inhibitors of BCR-ABL mutants and use thereof
US20250282764A1 (en) Imidazole heterocycle based compounds and methods of treating cancer
WO2025261327A1 (zh) 一种抗肿瘤药物
Wang et al. A potent icaritin derivative ameliorates Parkinson's disease via GPER-mediated mitophagy restoration and dopaminergic neuroprotection
CN120815187A (zh) Hdac6抑制剂与btk抑制剂的药物组合及其用途

Legal Events

Date Code Title Description
PA0105 International application

Patent event date: 20190118

Patent event code: PA01051R01D

Comment text: International Patent Application

PG1501 Laying open of application
A201 Request for examination
PA0201 Request for examination

Patent event code: PA02012R01D

Patent event date: 20200727

Comment text: Request for Examination of Application

E902 Notification of reason for refusal
PE0902 Notice of grounds for rejection

Comment text: Notification of reason for refusal

Patent event date: 20220310

Patent event code: PE09021S01D

E601 Decision to refuse application
PE0601 Decision on rejection of patent

Patent event date: 20220527

Comment text: Decision to Refuse Application

Patent event code: PE06012S01D

Patent event date: 20220310

Comment text: Notification of reason for refusal

Patent event code: PE06011S01I