KR20190031859A - Biodegradable Suture having Retainers and the method thereof - Google Patents

Abstract

The present invention relates to biodegradable suture and a manufacturing method thereof, wherein biodegradable suture, into which a plurality of retainers separately manufactured are inserted in the longitudinal direction to be fixated thereto, is inserted into a human body, thereby being able to firmly maintain body tissues through retainer structures. An embodiment of the method for manufacturing a biodegradable suture having retainers comprises the steps of: arranging a body of the degradable suture formed long in a longitudinal direction; arranging insertion holes through central parts of a plurality of the retainers made of biodegradable materials; inserting the retainers into the body of the suture to be spaced from each other along the outer circumferential surface of the body of the suture; and fixating the retainers on the outer circumferential surface of the body of the suture.

Description

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The present invention relates to a biodegradable suture having a retainer and a method for producing the same. More particularly, the present invention relates to a biodegradable suture which can securely fix a suture inserted into a human body through a retainer structure to a body tissue as a plurality of separately manufactured retainers are inserted in the longitudinal direction of the suture and fixed to the suture, And a manufacturing method thereof.

Recently, various medical seals for tissue fixation, including medical sutures, have been used for both non-knot sealing purposes and face lift purposes.

Facial laparoscopic surgery is a procedure to make the suture support the skin by inserting the suture under the facial skin and then pulling the suture. This method is widely used in recent years due to its advantages such as no need for skin incision, short treatment time and recovery period It is a procedure.

However, in the case of performing facial elevation using such a conventional suture, there is a problem that the suture inserted into the human body often comes out through the insertion hole before the fixation is formed between the body and the tissue.

A method of making a suture that can be anchored between body tissues for surgical tissue sealing and plastic surgery is described in U. S. Patent No. 2004/0060410 entitled " barbed suture "and U. S. Patent Application 2003/0041426 A1" And a method of cutting which is proposed in "Methods of forming barbs on a suture and apparatus for performing same" are typical examples, and the majority of the products currently commercialized by the method .

However, in the cutting method, since the surface of the suture yarn is cut to form barbs, the size and thickness of the barbs are limited, the ends of the barbs are too sharp to stimulate the surrounding tissues and nerves, And the strength of the suture yarn is reduced rapidly compared to the suture of the same size due to the damage of the suture yarn caused by the cutting method, have.

A lot of efforts have been made to improve this, and Korean Patent No. 10-1642962 discloses a method of forming a barb on the surface of a suture by pressing a suture using a mold.

However, in order to pressurize the suture to form a barbed shape, the suture must be heated to facilitate deformation, so that the quality of the suture is deteriorated due to damage or unexpected deformation of the suture due to heat.

Therefore, there is a need for a method of forming a structure that can be fixed to the body tissue on the surface of the suture without damaging the suture.

SUMMARY OF THE INVENTION It is an object of the present invention to provide a suture that can be fixed to a tissue in a body without damaging the suture by inserting and fixing a separately manufactured retainer into the suture, and a method of manufacturing the suture.

The technical object of the present invention is not limited to the above-mentioned technical objects and other technical objects which are not mentioned can be clearly understood by those skilled in the art from the following description will be.

An embodiment of a method of manufacturing a biodegradable suture having a retainer includes the steps of providing a biodegradable suture material body formed to be long in the longitudinal direction, preparing an insertion hole through a central portion of a plurality of biodegradable retainers, Inserting the suture body into the suture body and disposing the suture body apart from each other along the outer circumferential surface of the suture body, and fixing the retainer to the outer circumferential surface of the suture body.

The method may further include the step of providing the retainer in a cone shape.

Further, the fixation of the retainer and the suture body may be performed by heat-pressing the retainer at a temperature below the melting point.

In addition, the fixation of the retainer and the suture body may be performed by pressing the retainer and the suture body with a non-heated press.

Further, the suture body and the retainer may be made of polydioxanone material.

The retainer may be formed by forming a plurality of cone shapes by pressing the outer peripheral surface of the suture yarn and cutting each of the cone shapes.

Further, it may include a step of coating a surface of the suture body and the retainer with a lysosome-derived enzyme.

The method may further include aligning the tip portion of the cone shape of the retainer in the center direction so as to be symmetrical about the center portion of the suture body.

The method may further include aligning the tip portions on the cone-shaped portion of the retainer to face each other about any one portion of the suture body.

One embodiment of a biodegradable suture with a retainer may be manufactured and provided in the manner described above.

According to the method for producing a biodegradable suture having the retainer of the above-described embodiment, the retainer fixed to the internal tissue can be formed on the suture without being heated at high temperature to prevent deterioration in the quality of the suture, .

In addition, the retainer of the suture can be provided in a cone shape in which the tip portions are opposed to each other, thereby maximizing the tissue fixation force.

1 is a side view showing a biodegradable suture having a retainer according to an embodiment of the present invention.
2 is a conceptual view illustrating a process of forming a part of a biodegradable suture having a retainer according to an embodiment of the present invention.
3 is a side view showing a biodegradable suture having a retainer according to another embodiment of the present invention.

Hereinafter, some embodiments of the present invention will be described in detail with reference to exemplary drawings. It should be noted that, in adding reference numerals to the constituent elements of the drawings, the same constituent elements are denoted by the same reference symbols as possible even if they are shown in different drawings. In the following description of the embodiments of the present invention, a detailed description of known functions and configurations incorporated herein will be omitted when it may make the subject matter of the present invention rather unclear.

In describing the components of the invention, terms such as first, second, A, B, (a), (b), etc. may be used. These terms are intended to distinguish the constituent elements from other constituent elements, and the terms do not limit the nature, order or order of the constituent elements. When a component is described as being "connected", "coupled", or "connected" to another component, the component may be directly connected to or connected to the other component, It should be understood that an element may be "connected," "coupled," or "connected." In the same context, when an element is described as being formed on an "upper" or "lower" side of another element, the element may be formed either directly or indirectly through another element As will be understood by those skilled in the art.

FIG. 1 is a side view showing a biodegradable suture having a retainer according to an embodiment of the present invention, FIG. 2 is a conceptual view showing a process of forming a part of a biodegradable suture having a retainer according to an embodiment of the present invention And Fig. 3 is a side view showing a biodegradable suture having a retainer according to another embodiment of the present invention.

1, the overall structure of a biodegradable suture having a retainer and a manufacturing method thereof will be described.

The biodegradable suture 10 is composed of a suture body 100 and a retainer 200.

In the step of preparing the suture body 100, the suture body 100, which is long in the longitudinal direction, is cut to a proper length.

The suture body 100 is formed of a biodegradable material used for sewing, ligation and fixing of a human body tissue. The suture body 100 may be made of a biodegradable polymeric compound such as polydioxanone, polycaprolactone, polyglycine, polyglycolic acid, polyglyconate, And copolymers thereof, and the like.

The biodegradable suture body 100 may be inserted into the body and biodegraded and absorbed into the body, so that the incised body 100 can be used as a lifting chamber for sealing or inserting the tissue.

If the suture body 100 formed in the longitudinal direction is inserted into the body through a needle or an injector and is not fixed in the body, the suture body 100 is directly pulled out of the suture body 100 with the incision formed for injection of the suture body 100 It is difficult to use for purposes such as suturing or inserting the tissue.

To improve this, the retainer 200 is formed on the suture body 100, so that the structure of the retainer 200 and the structure of the body are fixed, so that the suture body 100 can be fixed in the body.

The step of forming the insertion hole in the retainer 200 is carried out through the center of the retainer 200 of the biodegradable material.

The retainer 200 may be formed of the same material as the suture body 100 and the material of the retainer 200 may be selected from the group consisting of Polydioxanone, PolyCaprolactone, Polyglactin, Poly Polymeric compounds having biodegradability such as polyglycolic acid and polyglyconate, and copolymers thereof, and the like.

The insertion holes of the retainer 200 can be formed by hollowing the central portion of each retainer 200 with a needle or a laser.

The retainer 200 may be provided with a plurality of pre-manufactured retainers 200 and may be inserted into the suture body 100. Alternatively, the retainer 200 may be directly manufactured by processing the suture yarn 500. [ The process of separately manufacturing the retainer 200 will be described later.

Thereafter, a step of inserting retainers 200 provided with insertion holes into the suture body 100 and arranging the retainers 200 apart from each other along the outer peripheral surface of the suture body 100 is performed.

The retainer 200 is inserted into the end of the suture material body 100 such that a plurality of retainers 200 are inserted along the outer circumferential surface of the suture material body 100 so that the inserted retainers 200 are spaced apart from each other have. Adjusting the number and distance of the retainers (200) inserted into the suture body (100), the fixing force of the body tissue and the biodegradable suture (10) can be adjusted.

The step of inserting and inserting the retainer 200 into the outer peripheral surface of the suture body 100 may be performed in various forms.

2, the step of arranging the cone-shaped retainer 200 inserted into the suture body 100 to be symmetrical about the center of the suture body 100 may be performed (FIG. 2A). More specifically, the cone-shaped tip portion of one retainer 200 is disposed so as to face the central portion of the suture body 100 with respect to the center of the suture body 100, and the tip portion of the cone- And may be symmetrically formed with respect to the center of the suture body 100 by arranging the suture body 100 toward the center of the body 100.

2, the cone-shaped retainer 200 inserted into the suture body 100 is aligned so that the retainers 200 on both sides face each other with respect to a part of the suture body 100 that is not the center of the suture body 100 (Fig. 2B). More specifically, the tip portion of the retainer 200 disposed on one side with respect to a certain portion of the suture body 100 is disposed toward the reference portion, and the tip portion of the retainer 200 disposed on the other side is also a reference And may be arranged so as to be opposed to each other with respect to a specific portion of the suture body 100. [

When the tip portion of the retainer 200 is disposed to face the central portion or a specific portion of the suture body 100, the binding force with the internal structure of the retainer 200 is structurally increased more than the tip portion of the retainer 200 is disposed only in the specific direction . Therefore, the biodegradable suture 10 having the structure in which the tip portion of the retainer 200 is opposed is used as a lifting chamber for facial elevation, and the skin tissue is strongly pulled, thereby maximizing the wrinkle reduction effect. By adjusting the arrangement and the number of the retainers 200, it is possible to manufacture a suture having different characteristics according to the characteristics of the skin tissue.

The retainer 200 inserted into the suture body 100 needs to be fixed to the suture body 100 so that the retainer 200 inserted into the suture body 100 is not separated from the suture body 100. Therefore, .

Fixation of the suture body 100 and the retainer 200 may be implemented in various forms.

For example, the retainer 200 and the suture body 100 may be deformed and fixed with a pressing press 600 to be described later. In this case, it is easy to maintain the structure of the retainer 200 in the suture body 100 because the retainer 200 is not thermally deformed.

As another example, the retainer 200 inserted into the outer surface of the suture body 100 may be heated and compressed at a temperature below the melting point to fix the suture body 100 and the retainer 200. The retainer 200 is heated at a temperature below the melting point, but a portion of the retainer 200 which is in contact with the suture body 100 due to the pressure due to being pressed together with the heat may be partially melted and fixedly engaged with the suture body 100. The heating and pressing of the retainer 200 may be performed by a separate heating press (not shown) or the like.

As another example, the suture body 100 and the retainer 200 may be attached to each other using a biocompatible adhesive that is less reactive with the living body.

On the other hand, the step of providing the retainer 200 in a cone shape having a tip portion may be performed before the step of forming the insertion hole in the retainer 200. [ Here, the tip portion may be an end portion having the narrowest width in the retainer 200 having a conical shape or a conical shape. A configuration in which a plurality of retainers 200 having a cone shape are inserted into the suture material body 100 can be formed as shown in FIG. The retainer 200 may be formed of polygonal horns in addition to the cone shape.

On the other hand, a step of coating a surface of the suture body 100 or the retainer 200 with a lysosome-derived enzyme may be further performed.

More specifically, the surface of the suture body 100 or the retainer 200 may be coated with a lysosome-derived enzyme extracted from egg white such as eggs of poultry. When the suture body 100 or the retainer 200 having such a coating layer remains in the skin tissue of the human body, interaction between the coating layer and the skin tissue maximizes the lifting effect by the tissue regeneration effect .

The retainer 200 may be manufactured by separately pressing the stitched yarn 500. [

Referring to FIG. 3, the suture yarn 500 is a raw material for manufacturing the suture body 100, and may be formed of the same biodegradable polymeric compound as the suture body 100 and a copolymer thereof. The suture yarn 500 may be used as the suture body 100 itself or may be pressed through a pressure roller (not shown) to reduce the thickness thereof so that the suture body 100 can be used.

The retainer 200 may be manufactured by processing the suture yarn 500 and then inserted into the suture body 100.

More specifically, the unprocessed suture yarn 500 is heated to a temperature below the melting point through a heating device (not shown) to facilitate processing (Fig. 3A). For example, the heating device can be heated to a temperature of about 55-60 DEG C or less when the suture yarn 500 is made of a polycaprolactone material, and when the suture yarn 500 is formed of a polydioxanone material And can be heated to a temperature of about 50 ° C or less. However, the heating of the stitched yarn 500 may not be performed in accordance with the molding press 300. That is, when the molding press 300 is provided to perform non-heating pressurization, the heating device, the heating process, and the like may be omitted.

The suture yarn 500 is pressed on both sides of the sewing yarn 500 by a molding press 300 having a plurality of cone-shaped molds (Fig. 3B).

A plurality of cone shapes are formed on the outer circumferential surface of the pressurized suture yarn 500. To separate each of the plurality of cone shapes, the shape of the cone is separated using the cutting tool 400 to manufacture the respective retainers 200 (Figure 3c).

At this time, the cutting tool 400 may be a sharp-tipped cutter, but various cutting tools such as a laser may be used.

Thereafter, the cut cone-shaped retainer 200 is inserted into the suture body 100 to dispose the retainer 200 (FIG. 3D). Thereafter, the retainer 200 and the suture body 100 are pressed and fixed using a non-heating press 600 without heating (FIG. 3E). The fixing of the retainer 200 and the suture body 100 may be performed by using a non-heating press 600 or by heating and pressing at a temperature below the melting point of the suture body 100 or the retainer 200, Or may be attached with a biocompatible adhesive with low reactivity.

INDUSTRIAL APPLICABILITY As described above, according to the method for producing a biodegradable suture having a retainer, it is possible to prevent the quality of the suture from deteriorating by forming a retainer, which is fixed to the internal tissue, on the suture surface without heating at high temperature, A retainer that can be made of a metal can be manufactured.

In addition, the retainer of the suture can be provided in a cone shape in which the tip portions are opposed to each other, thereby maximizing the tissue fixation force.

It is to be understood that the terms "comprises", "comprising", or "having" as used in the foregoing description mean that the constituent element can be implanted unless specifically stated to the contrary, But should be construed as further including other elements. All terms, including technical and scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs, unless otherwise defined. Commonly used terms, such as predefined terms, should be interpreted to be consistent with the contextual meanings of the related art, and are not to be construed as ideal or overly formal, unless expressly defined to the contrary.

The foregoing description is merely illustrative of the technical idea of the present invention, and various changes and modifications may be made by those skilled in the art without departing from the essential characteristics of the present invention. Therefore, the embodiments disclosed in the present invention are intended to illustrate rather than limit the scope of the present invention, and the scope of the technical idea of the present invention is not limited by these embodiments. The scope of protection of the present invention should be construed according to the following claims, and all technical ideas within the scope of equivalents should be construed as falling within the scope of the present invention.

10: biodegradable suture 100: suture body
200: retainer 300: molding press
400: Cutting tool 500: Suture yarn
600: Pressing Press

Claims (10)

Providing a biodegradable suture body formed in a lengthwise direction;
Providing an insertion hole through a center portion of a plurality of retainers of a biodegradable material;
Inserting the retainer into the suture body and disposing the retainer apart from each other along an outer circumferential surface of the suture body; And
And fixing the retainer to the outer peripheral surface of the suture material body. The method according to claim 1,
Further comprising a step of providing the retainer in a cone shape. The method of claim 1, wherein the securing of the retainer and the suture body
And a retainer which is carried out by heating and pressing at a temperature equal to or lower than a melting point of said retainer. 2. The method of claim 1, wherein the securing of the retainer and the suture body
And a retainer that is performed by pressing the retainer and the suture body with a non-heating press. The method according to claim 1,
Wherein the suture body and the retainer have a retainer made of polydioxanone material. The retainer according to claim 1,
A method for producing a biodegradable suture including a plurality of cone shapes formed by pressing an outer peripheral surface of a suture yarn and a retainer formed by cutting each cone shape. The method according to claim 1,
And a step of coating a surface of the suture body and the retainer with a lysosome-derived enzyme. 3. The method of claim 2,
Further comprising the step of aligning the tip portion of the conical shape of the retainer in the central direction so as to be symmetrical about the center portion of the suture material body. 3. The method of claim 2,
Further comprising the step of aligning the retainer in such a manner that the tip portions of the cone-shaped portion of the retainer are opposed to each other with respect to a portion of the suture body. A biodegradable suture having a retainer produced according to the method of any one of claims 1 to 9.

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