KR20180106756A - Method and apparatus with improved accuracy - Google Patents

Abstract

According to one exemplary embodiment of the present invention, a modular automatic analysis apparatus using a circular cartridge, capable of performing centrifugation, comprises: a main frame; an X-axis transfer unit reciprocating in the X-axis direction with respect to the main body frame; a circular cartridge storage housing installed on the X-axis transfer unit so as to be able to reciprocate in the X-axis direction by the X-axis transfer unit; one rotation driving unit installed in the circular cartridge storage housing and capable of rotating at high speed to perform step rotation or centrifugation at predetermined intervals; a circular cartridge formed on an upper surface of the circular cartridge storage housing to be connected to the rotation driving unit to be able to rotate with respect to the rotation driving unit, and having wells disposed at regular intervals in the circumferential direction of a disk-shaped main body; a tip ascending and descending unit picking up a tip to ascend and descend the same; a measurement unit measuring a reaction in the wells; a z-axis driving unit including the tip ascending and descending unit and the measurement unit to reciprocate in a z-axis direction with respect to the main body frame; and a control unit (c) controlling an automatic immunoassay device. According to the present invention, it is possible to separate the whole blood into red blood cells and plasma to use the same by using the circular cartridge, and thus, an individual input by an inspector is not needed, and accuracy of measurement can be enhanced. The modular automatic analysis apparatus is made into a relatively small size and has an optimized configuration such that the modular automatic analysis apparatus can be coupled and extended in a modular way. A diagnosis of various test items or various diseases can be made in the shortest time.

Description

BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates to a circular type cartridge capable of centrifugal separation,

The present invention relates to a circular type cartridge capable of centrifugal separation and a modular automatic analyzing apparatus using the cartridge, wherein a circular type cartridge is used to separate whole blood into red blood cells and plasma, A centrifugal separable circular cartridge which can be diagnosed in a shortest time for various items and various diseases by miniaturization and optimization of the design and can be modularly combined and expanded and a modular automatic analyzer using the same will be.

BACKGROUND ART [0002] In automatic analyzers for measuring components in biological samples such as blood samples and urine samples, it has been the mainstream to measure biochemical items such as enzymes. However, in recent years, the measurement of immunological items such as hormones and tumor markers is also increasing. In the biochemical automatic analyzer, the substance to be examined is measured by the transmitted light and the scattered light by using the fact that the absorbance of the reaction liquid changes due to the biochemical reaction in the blood sample.

On the other hand, in a serum immunoassay apparatus for an immunological item, an antibody or an antigen specifically binding to each test substance to be prepared as a reagent, a labeled antibody or an antigen expressed in a fluorescent dye or the like, B / F separation is carried out after subjecting the cells to reactive binding, and the heterogeneous assay for detecting the labeled antibody or the labeled antigen is used to measure the substance to be examined such as hormone in the biological material with high sensitivity.

Here, the B / F separation means to separate the binding component (Bind; B) to be analyzed and the free component (Free; F) that is not to be analyzed.

In recent years, there has been an increasing demand for measurement of biochemical items and simultaneous measurement of multiple immunological items for the same specimen.

For example, it may be necessary to simultaneously test for cancer and heart disease, or to measure biochemical and immunological items simultaneously for accuracy in thyroid examination.

However, in the conventional automatic analyzing apparatus, after the measurement in the serum immunoassay apparatus is completed with the linear cartridge structure, the sample is once again measured in the biochemical automatic analyzer, or after the measurement is completed in the biochemical automatic analyzer It was necessary to perform measurement of the sample once more in the serum immunoassay apparatus.

In addition, for the sake of precise results, the test results obtained by only one automatic analyzer are often insufficient.

In particular, in the case of immunocompetent devices for diagnosing cardiovascular diseases, there is a function to simultaneously diagnose 6 channels, but there is a disadvantage that equipment can not be used during the test. If emergency patients are hospitalized at the same time, . Therefore, there is a need for a multi-channel analysis function capable of individual driving as an automatic analyzing apparatus used in an emergency environment.

However, in this case, when using a plurality of conventional automatic analyzing apparatuses, there is a problem that the total size is too large.

In addition, the immunoassay device measures the concentration of a specific biomarker protein in human plasma or serum. When using plasma or serum directly as a measurement sample, it is not necessary to calibrate the measurement concentration, but when the whole blood is used, Should be used to calibrate the measured concentration.

Therefore, most existing equipment must input the hematocrit and the type of sample (whole blood / plasma / serum) separately measured from outside.

In other words, conventional automatic analyzers are often troublesome because the whole blood is separated into red blood cells and plasma, or the red blood cell count of the subject is input to the automatic analyzer.

It is an object of the present invention to solve such a problem, and it is an object of the present invention to provide an automatic analyzer which separates whole blood into red blood cells and plasma using a circular type cartridge, And can be miniaturized and optimized in design so that the size of the whole system can be reduced even if several modules can be combined and expanded in a modular manner and a centrifuge capable of being diagnosed in the shortest time for various items and diseases Type cartridge and a modular automatic analyzing apparatus using the same.

A modular automatic analyzer using a centrifugable circular type cartridge according to an embodiment of the present invention includes a main body frame, an X-axis conveying unit that reciprocates in the X-axis direction with respect to the main frame, And a rotary drive unit installed in the circular type cartridge housing and capable of high-speed rotation for a stepwise rotation or a centrifugal separation at a predetermined interval, Type cartridge which is mounted on the upper surface of the circular type cartridge housing housing so as to be rotatably driveable with respect to the driving part and has wells spaced apart from each other by a predetermined distance in the circumferential direction of the disk- A measuring unit for measuring a reaction in the well, A Z-axis driver for reciprocally driving the body frame in the Z-axis direction; And a control unit (C) for controlling the automated immunoassay analyzer.

The centrifugal separable circular type cartridge according to an embodiment of the present invention includes a centrifugal well for centrifugal separation of the sample, which is installed on the circular type cartridge receiving housing, and at least two wells .

According to the embodiment of the present invention, by using the circular type cartridge, the whole blood is separated into red blood cells and plasma in the automatic analyzer so that the individual input of the inspector is not required, the accuracy of measurement can be increased, Provided is a modular automatic analyzer having a circular type cartridge capable of reducing the size of the entire system even if several modules can be combined and extended in an optimized manner, and diagnosing the various items and various diseases in the shortest time .

1 is a perspective view of a modular automatic analyzer having a circular type cartridge according to an embodiment of the present invention.
Fig. 2 is an exploded perspective view of Fig. 1 for explaining reciprocal driving in the X-axis direction of the circular type cartridge housing housing and replacement of the circular type cartridge.
Fig. 3 is an exploded perspective view of a portion B of Fig. 2 for explaining the configuration of the circular type cartridge housing.
4 is a conceptual perspective view illustrating the construction and use of a circular type cartridge according to an embodiment of the present invention.
5 is a cross-sectional view illustrating a double door structure of a modular automatic analyzer using a circular type cartridge according to an embodiment of the present invention.
6 is an exploded perspective view showing an expanded version of a modular automatic analyzer having a circular type cartridge according to an embodiment of the present invention.
7 is a perspective view showing a basic type and an extended type of a modular automatic analyzer having a circular type cartridge according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings so that those skilled in the art can easily carry out the present invention. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In order to clearly illustrate the present invention, parts not related to the description are omitted, and similar parts are denoted by like reference characters throughout the specification.

Throughout the specification, when an element is referred to as "comprising ", it means that it can include other elements as well, without excluding other elements unless specifically stated otherwise. Also, the terms "to", "to", "to", and "modules" in the specification mean units for processing at least one function or operation, and may be implemented by hardware or software or a combination of hardware and software .

Hereinafter, a modular automatic analyzer having a circular type cartridge according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings.

1 to 3, a modular automatic analyzer 1 having a circular type cartridge according to an embodiment of the present invention includes a plate-like main body frame 10 disposed at the bottom of an outer housing 1a, An X-axis transferring unit 20 reciprocating in the X-axis direction with respect to the main body frame 10, and an X-axis transferring unit 20 configured to transfer the X-axis transferring unit 20 reciprocally in the X- Type cartridge accommodating housing 30 installed in the circular-type cartridge accommodating housing 30, a circular-type cartridge accommodating housing 30 provided in the circular-type cartridge accommodating housing 30, A circular type cartridge 50 provided on the upper surface of the housing 30 and having at least two or more wells 53 spaced apart from each other in a circumferential direction with respect to the disk body 51; For sample injection, mixing, washing A tip ascending / descending section 60 for picking up and dropping a tip 61 for performing an analysis process of the at least two or more wells 53, a measuring unit 70 for measuring a reaction in the at least two wells 53, A magnetron 80 for generating microwaves to form a reaction in the well 53 and a tip ascending and descending section 60 and a measuring unit 70. The magnetron 80 is disposed in the Z- A Z-axis driving unit 90 for reciprocating driving, and a control unit C for controlling the respective components of the automatic immunoassay apparatus 1.

In the automatic immunoanalyzer 1 having such a structure, the main frame 10 has an L-shaped opening structure, and the X-axis moving rail 21 attached to the lower portion of the circular type cartridge housing 30 is movable And a base portion 11 extending in the X-axis direction in which the fixed guide rail 23 of the X-axis driving portion 20 and the auxiliary roller 25 for assisting the movement of the X-axis moving rail 21 are coupled And a side wall portion 13 extending in the Z-axis direction with respect to the base portion 11. As shown in Fig.

The X-axis driving unit 20 can freely move in the X-axis direction along the fixed guide rail 23 with respect to the base unit 11 of the main body frame 10, as described above, So that the circular type cartridge receiving housing 30 can be taken out to easily mount and replace the circular type cartridge 50, and other equipment can be easily repaired.

The circular type cartridge housing 30 rotates the circular type cartridge 50 and the circular type cartridge 50 at a predetermined rotational speed in an hollow hollow state and simultaneously rotates to rotate the circular type cartridge 50 For supplying a predetermined heat source such that the well 53 formed around the fan unit 100 and under the circular type cartridge 50 has a predetermined temperature atmosphere, The accommodating chamber 31 in which the heater unit 200 is accommodated and the partition wall portion 33 provided inside the circular type cartridge accommodating housing 30 so that the accommodating chamber 31 can serve as a predetermined chamber .

The circular type cartridge housing 30 may include a tip mounting portion 36 for mounting and dismounting the tip 61 independently of the circular type cartridge accommodating chamber 31.

The tip mounting hole 36a further includes a tip receiving hole 36a having a shape corresponding to the tip so as to receive and protect the tip 61, Is disposed adjacent to the accommodating chamber (31) so as to be easily moved to the test position of the circular type cartridge (50).

On the other hand, whether the circular type cartridge housing 30 is at a position between the test position of the tip 61 in which the sample test is performed and the mounting / dismounting position of the tip 61 before or after the start of the sample test, Can be automatically confirmed by using the position sensor 300 installed along the side wall of the circular type cartridge housing 30. [

Accordingly, the start and end points of the sample test process can be clearly known, and the measurement unit 70, the magnetron 80, and the like can be prevented from being operated at the attachment and detachment positions of the tip 61.

A power line connection hole 33a through which a power line for supplying power to the heater unit 200 passes and a through hole 33b through which the rotation axis 41 of the rotation driving unit 40 passes are formed in the partition wall 33, A mounting hole 33c through which fixing means (not shown) for fixing the rotation driving portion 40 is inserted and a communication hole 33d communicating with the tip receiving hole 36a.

The fan unit 100 is formed with a coupling protrusion 110a which is coupled to the coupling groove 51a of the center hole of the circular type cartridge 50 to support the circular type cartridge 50 rotatably and rotatably Type cartridge supporting portion 110 and a wing portion 130 extending from the circular type cartridge supporting portion 110. The cartridge supporting portion 110 is coupled to the center of the circular type cartridge supporting portion 110, And a cartridge holder 150 connected to the rotary shaft 41 to transmit the rotational force of the rotary drive unit 40 to the circular type cartridge 50 and the blade unit 130.

A plurality of the wings 130 may be spaced apart from each other at a predetermined interval below the circular type cartridge support 110, or may be formed in a single flange shape.

The rotation drive unit 40 is coupled to the rotation shaft 41 and the rotation shaft 41 so that each well 53 of the circular type cartridge 50 is rotated step by step under the control of the control unit C, And one motor 43 that is disposed at the lower portion of the tip 61 or rotates at a high speed so as to centrifuge the sample in the well 53.

The motor 43 may be a step motor, a spindle motor, a BLDC motor, or the like so as to be able to perform the step rotation and the high-speed rotation at the same time.

The heater unit 200 may be a heater coil that generates heat when power is applied.

The heater unit 200 includes a heating block 210 which is a heat-dissipating metallic material in the form of a bowl that receives at least two wells below the circular cartridge 50 and a plate-like thermistor 230 installed at the bottom of the heating block 210 The heater unit 200 may be installed at a predetermined distance from the bottom of the hollow chamber 31 to be adhered to the periphery thereof.

The heating block 210 is made of aluminum having good heat dissipation property. The heating block 210 can be coupled with the fan unit 100 to quickly heat the inside of the accommodating chamber 31 to a temperature for testing. After the test, have.

When the heat source is applied to the heater unit 200, a wing portion 130 extending from the circular type cartridge supporting portion 110 with respect to the internal space of the accommodating chamber 31 is rotated by the rotation of the motor 43, And the temperature can be made fast and even as in the chamber.

Referring now to FIG. 4, a circular type cartridge according to an embodiment of the present invention will be described in detail.

4 is a conceptual perspective view illustrating the construction and use of a circular type cartridge according to an embodiment of the present invention.

4, the circular type cartridge 50 according to an embodiment of the present invention includes a center hole 51a of a disc-shaped main body 51, At least one pair of coupling grooves 51ab may be formed.

Not only the engaging groove 51ab serves as a positioning part for determining the position of the at least two wells 53 but also a radial direction outer side of the at least two wells 53, And an origin display unit 303 indicating a starting point of the automatic analysis process by the movement.

Therefore, the well adjacent to the origin display part 303 is used as the centrifugal well 55, the well 53 at the farthest away position is used as the detection well, and the magnetic particle well (57).

That is, when the circular type cartridge 50 is mounted to the circular type cartridge accommodating chamber 31 using the origin display unit 303 and the engaging groove 51ab, it is possible to easily measure the origin.

The at least two other wells 53 may be covered with a single film-like cover portion 50a to prevent contamination. The centrifugation well 55 contains a sample such as blood, A cap 55a for covering the opening may be separately provided to prevent leakage to the outside.

The cap 55a prevents the sample such as blood from escaping during centrifugation and allows the tip 61 to access the tip 60 so that the plasma and serum can be separated after centrifugation. (Thin) through which the tip 61 can penetrate, and a rim is formed as close as possible to the center so that the center can be held firmly even when the tip 61 penetrates.

A position sensor 300 for recognizing the position by taking each well 53 position information for reacting the reagent at each well 53 position of the circular type cartridge 50 is provided in the circular type cartridge receiving housing 30 Axis direction at a specific position with respect to the side surface of the base plate.

Also, corresponding to the position sensor 300, each of the wells 53 of the circular type cartridge 50 may further include a position indicator 301 indicating position information of each well 53.

The position indicator 301 may be elongated in the y-axis direction at the top end of the circular-type cartridge housing 30 to indicate a test position and a mounting and dismounting position of the tip 61, which will be described later in detail.

The control unit C interlocks with the position sensor 300 that reads the position indicating unit 303 displayed on each cell 53 of the circular type cartridge 50 during the stepwise rotation of the rotation driving unit 40, It is possible to control the stepwise rotation to each cell 53.

A centrifugal separation well 55 containing a whole blood sample in the well 53 is centrifuged to centrifugally separate the whole blood sample in a centrifugal direction so as to separate plasma and blood cells without contaminating other wells or devices It can be configured to be inclined at an angle.

The tip 61 may be coupled to the tip ascending and descending portion 60 in a variety of ways so that the magnetic particles in the magnetic particle well 57 can be attached to and detached from the tip 61 .

In the automatic analyzer according to an embodiment of the present invention, the measuring unit 70 is configured to detect a reaction using a chemiluminescence enzyme immunoassay (CLEIA) method, By driving the steel portion 60, an antibody labeled with a predetermined indicator is mixed with the specimen to form an immunocomplex, and the antibody that is not bound is removed, and then the chemiluminescent substrate is added to the immunocomplex.

When the immunocomplex is incubated for a short time in the chemiluminescent substrate, luminescence is detected by an enzymatic reaction.

The magnetron 80 functions to generate microwaves to add a chemiluminescent substrate to the immunocomplex, and the measuring unit 70 may include an optical amplifier for measuring the light emission.

The Z-axis driving unit 90 includes a driving motor 91 for providing a Z-axis driving force and a slide unit 90 for slidingly moving the tip up / down driving unit 60 in the Z- (95) for providing hydraulic pressure for pipetting the tip (61) attached to the tip ascending / descending driving part (60), a tip lifting / lowering driving part (60) 95, a magnetron 80, and a Z-axis plate 97 for fixing and supporting the measuring unit 70.

The modular automatic analyzer 1 having the circular type cartridge according to the embodiment of the present invention is configured such that the circular type cartridge 50 is loaded into the automatic analyzer 1 by the X- It is possible to perform a quick analysis within 15 seconds by the operation of the rotation driving unit 40 for stepwise rotating the circular type cartridge 50 and the Z-axis driving unit 90 for driving the tip ascending / descending section 60 have.

Referring briefly to FIG. 4, an automatic immunoassay method using a modular automatic analyzer 1 having a circular type cartridge according to an embodiment of the present invention will be briefly described.

In the modular automatic analyzer 1 having a circular type cartridge according to an embodiment of the present invention, various solutions may be stored in the well 53 of the circular type cartridge 50 or the tip 61 may be placed .

4, for example, the sample is stored in the No. 1 well 53a and the tip 61 is placed. In the No. 2 well 53b, the sample containing the bead solution containing magnetic particles is stored In the third well 53c, a first reagent for binding the magnetic particles to a specific component in the sample is mixed with the specimen. In the fourth well 53d, the specimen and the antibody are reacted, 5, 7 to 9 (53e, 53g to 53i), B / F separation is carried out by washing, and a labeling substance which causes luminescence by an electrochemical reaction is formed in the sixth well 53f The second reagent for binding to a specific component in the sample is stored, and the buffer solution containing a substance that induces the electrochemiluminescence of the labeling substance is stored in the 10th well 53j. In the 11th well 53k, And the reaction product is stored in the 12th well 531, The measurement can be made by the unit 70 in accordance with the reaction program of the control unit.

In this way, the circular type cartridge 50 is filled with the sample, the buffer solution, the washing solution, and various reagents, and the circular type cartridge 50 is inserted into the circular type cartridge receiving housing Type cartridge receiving housing 30 is returned to the original position and the circular type cartridge 50 is loaded into the automatic analyzer 1.

The first well 53a is disposed at the lower portion of the tip ascending and descending portion 60 and the tip ascending and descending portion 60 is moved in the Z axis direction of the Z axis driving portion 90 by the step rotation of the rotation driving portion 40. [ And the tip 61 is mounted on the tip ascending / descending section 60. [0064]

The rotation driving unit 40 rotates at a high speed for a predetermined time to centrifugate whole blood contained in the first well 53a to separate into blood cells / plasma.

Therefore, according to the embodiment of the present invention, it is not necessary for the operator to perform centrifugal separation in advance from the outside of the automatic analyzer 1, to recognize the whole blood, the plasma, and the erythrocyte volume ratio for correction separately.

At this time, a heat source is applied through the heater unit 200 by the control unit (c), and the fan unit (200) connected to the rotation axis (41) of the rotation driving unit (40) (31) is circulated through the air to keep it at a constant temperature like a chamber.

The tip 61 is lowered into the first well 53a by the tip ascending and descending section 60 and the plasma is pipetted. After the tip 61 is lifted by the tip ascending and descending section 60, The tip ascending and descending section 60 is lowered and the plasma is stored in the second well 53b as a specimen when the second well 53b is disposed below the tip ascending / descending section 60 by the step rotation of the tip ascending / Be able to

The rotation driving unit 40 rotates the sample in the third well 53c and the plasma of the second well 53b in the third well 53c by the step rotation to the up and down driving of the tip ascending and descending section 60 .

The rotation driving unit 40 performs an immune reaction by irradiating the microwaves with the magnetron 80 in the fourth well 53d by the step rotation to apply an immune response to the microwaves by using the washing solution contained in the fifth well 53e, The tip 61 can be driven up and down by driving the tip ascending / descending section 60 to be cleaned for B / F separation.

A labeling reaction that causes luminescence by the electrochemical reaction in the sixth well 53f to bind to a specific component in the sample is caused to occur, and washing is performed according to the protocol of the control unit C, Proceed with the test.

When the reaction material is generated in the 12th well 53r, the rotation driving unit 90 is used to measure the position of the No. 7 well 53g, that is, the lower part of the measurement unit 70, The tip 61 is separated from the tip ascending and descending section 60 and placed in the No. 1 well 53a and the tip 61 is separated from the tip ascending and descending section 60. Then, The unloading unit 50 can be unloaded.

As described above, according to the modular automatic analyzer 1 using the circular type cartridge according to the embodiment of the present invention, centrifugal separation is possible using the cartridge 50 of the circular type, so that blood cells / plasma of whole blood are separated Users can get accurate results without having to enter a separate hematocrit,

Of course, the arrangement of these wells 53 may be appropriately changed depending on the immunoassay environment. After the solution is stored in each well 53, immersion analysis work such as stirring and attachment is carried out by inserting the tip 61, and driving of the tip 61 can be controlled in various ways .

Referring now to FIG. 5, a description will be given of a method of manufacturing a modular automatic analyzer 1 using a circular type cartridge according to an embodiment of the present invention, Will be described in detail.

5 is a cross-sectional view illustrating a double door structure of a modular automatic analyzer 1 using a circular type cartridge according to an embodiment of the present invention.

The circular type cartridge housing 30 has a tip mounting portion 36 for mounting and dismounting the tip 61 independently of the circular type cartridge accommodating chamber 31, When the door of the external housing 1a is constituted by one door, it can be moved back and forth with respect to the external housing 1a in accordance with the movement of the circular type cartridge housing 30. FIG.

On the other hand, in the modular automatic analyzer 1 using the circular type cartridge according to the embodiment of the present invention, in order to solve such a problem, the circular type cartridge receiving housing 30 can be taken out independently A first door 1aa which does not move back and forth with respect to the external housing 1a accommodating the first door 1aa and a second door 2aa which is double with the first door 1aa, So that the second door 2aa can be moved back and forth.

At this time, the second door 2aa is connected to the circular type cartridge housing 30 by the elastic member 3a so as to be positioned between the test position of the tip 61 and the mounting / dismounting position of the tip 61 Type cartridge housing housing 30, but the first door 1aa of the exterior housing 1a can be held without moving back and forth without a large vibration by absorbing the vibration.

In addition, the position sensor 300 is attached to the side surface of the circular type cartridge housing 30 to interlock with a position indicator 301 for indicating a test position of the tip and a mounting and dismounting position of the tip, It is possible to prevent the malfunction of other equipment.

Referring now to Figures 6 and 7, an expanded version of a modular automatic analyzer having a circular type cartridge according to one embodiment of the present invention will be described.

FIG. 6 is an exploded perspective view showing an expanded type of a modular automatic analyzer having a circular type cartridge according to an embodiment of the present invention, and FIG. 7 is an exploded perspective view showing a modular automatic analyzing apparatus having a circular type cartridge according to an embodiment of the present invention. In which FIG.

6, a modular automatic analyzer 1 having a circular type cartridge according to an embodiment of the present invention is characterized in that the circular type cartridge receiving housing 30 has at least two, And may be provided in the housing 1a and configured to be operable independently from the one external housing 1a.

Of course, the tip 61, the tip up and down driving unit 60, the measuring unit 70, and the magnetron 80 for the circular-type cartridge receiving housing 30 may correspond to each other.

When the centrifuge is being centrifugally separated from the circular cartridge 50 in one external housing 1a, the tip ascending / descending section 60 and the measuring unit 70 are connected to the adjacent circular type cartridge receiving housing 30 A Y-axis direction transferring unit 92 in the form of a belt may be additionally provided and moved in the Y-axis direction.

The Z-axis driving section, the measuring section unit, and the tip ascending / descent opening section so that at least one of the Z-axis driving section, the measuring section unit, and the tip ascending / At least one of which can be coupled to the Y-axis direction transferring portion 92 movable in the y-axis direction.

7, a modular automatic analyzer 1 having a circular type cartridge according to an embodiment of the present invention includes a circular type cartridge receiving housing 30 in an external housing 1a having an input portion 410, Or at least two circular-type cartridge receiving housings 30 may be installed so as to be independently usable with respect to one external housing 400a, and the measuring unit unit 80, the tip ascending / Axis driving unit 90 such as a magnetron 80 and a magnetron 80. A plurality of outer housings having at least two circular type cartridge receiving housings 30 may be provided adjacent to each other .

The modular automatic analyzer 1 having the circular type cartridge according to an embodiment of the present invention can be easily expanded by its modular design, can cope with various market situations, and can easily A / S.

The modular automatic analyzer 1 having the circular type cartridge according to the embodiment of the present invention is driven separately and can be advantageous for emergency treatment when several units are installed.

The modular automatic analyzer 1 having a circular type cartridge according to an embodiment of the present invention is advantageous in emergency situations within 15 minutes of analysis time and can be centrifuged in the automatic analyzer 1, / It is possible to improve the analysis correlation between blood cells and increase the measurement accuracy.

The modular automatic analyzer 1 having the circular type cartridge according to the embodiment of the present invention can improve the space utilization by using the circular type cartridge 50 by the compact size.

10: main body frame 20: X-axis driving part
30: circular type cartridge receiving housing 40: rotation driving part
50: circular type cartridge 60: tip up / down driving part
70: Measuring unit 80: Magnetron
90: Z-axis driving part

Claims (16)

Body frame;
An X-axis transferring unit reciprocatingly moving in the X-axis direction with respect to the main body frame;
A circular-type cartridge receiving housing installed to the X-axis conveying unit so as to be reciprocally transportable in the X-axis direction by the X-axis conveying unit;
A circular type cartridge provided on the circular type cartridge receiving housing and having a centrifugal well for centrifugation of the sample and at least two wells for performing a test on the sample in a rotating type;
A rotation driving unit for rotating the circular type cartridge at a predetermined interval at a high speed for stepwise rotation or centrifugal separation and installed inside the circular type cartridge housing;
A tip ascending and descending portion for picking up a tip for performing a test on the well and ascending and descending;
A measuring unit for measuring a reaction in the well;
A Z-axis driver for reciprocally driving the main body frame in the Z-axis direction, the Z-axis driving unit including the tip ascending and descending portion and the measuring unit; And
And a controller for controlling the X-axis conveying unit, the rotation driving unit, the team ascending / descending unit, the measuring unit, and the Z-axis driving unit to enable automatic immunoassay analysis. The method according to claim 1,
The circular type cartridge housing includes a hollow chamber having an inner hollow therein for receiving the circular type cartridge thereon, and a cylindrical hole provided in the hollow chamber and being engaged with a central hole of the circular type cartridge, A heater unit provided around the fan unit for supplying a predetermined heat source so that the well under the circular type cartridge becomes a predetermined temperature atmosphere; and a heater unit for simultaneously driving the circular type cartridge and the fan unit And a centrifugal separable circular type cartridge including the rotation driving unit. 3. The method of claim 2,
Wherein at least one pair of coupling grooves are formed in the center hole of the circular type cartridge at positions opposing to each other for engaging with the fan unit and an automatic analysis process is performed on the outside of the coupling groove in the radial direction by movement of the at least two wells And a origin display unit for indicating a starting point of the centrifugal separator. 3. The method of claim 2,
The heater unit includes a heating block, which is a heat radiating metallic material having a shape to receive a well under the circular cartridge, and a plate-shaped thermistor installed at the bottom of the heating block. The heater unit is installed at a predetermined distance from the bottom of the hollow chamber Wherein the cartridge is a centrifugal separator. 3. The method of claim 2,
The fan unit includes a circular-type cartridge supporting portion on the disk, on which an engaging projection is formed to be engaged with an engaging groove of the center hole of the circular type cartridge, a wing extending from the circular-type cartridge supporting portion, And a cartridge holder connected to the rotation axis of the rotation driving unit. The method according to claim 1,
The centrifugal well is formed to protrude in the direction of centrifugal force and covers the opening of the centrifugal well and includes a thin cap through which the tip can penetrate in accordance with movement of the tip ascending / descending portion. Modular automatic analyzer. 3. The method of claim 2,
The control unit controls the rotation driving unit in conjunction with a first position sensor provided at the center of the circular type cartridge at the time of the step rotation or centrifugally separates the centrifugal separator Modular automatic analyzer using circular type cartridge. The method according to claim 6,
The circular type cartridge housing includes a tip mounting portion for mounting and detaching the tip independently of the circular type cartridge accommodating chamber,
Wherein the circular type cartridge housing further comprises a second position sensor for indicating a test position of the tip and a mounting and dismounting position of the tip. 8. The method of claim 7,
The circular type cartridge housing corresponding to the second position sensor senses a test position of the tip and a mounting and dismounting position of the tip, and a position indicator installed on a side wall portion protruding in the Z-axis direction with respect to the main body frame A modular automatic analyzer using a centrifugal round type cartridge further comprising: The method according to claim 1,
A first door formed in an outer housing for accommodating the modular automatic analyzing apparatus for independently taking out the circular type cartridge receiving housing,
Wherein the second door is connected to the circular type cartridge housing by an elastic member and moves between a test position of the tip and a mounting and dismounting position of the tip Wherein the first door is fixed to the exterior housing, and the first door is fixed to the exterior housing. The method according to claim 1,
The main body frame has an L-shaped opening structure having a base portion on which the X-axis driving portion is mounted and a side wall portion on which the Z-axis driving portion is mounted, and the circular type cartridge housing is supported by the X- A modular automatic analyzer using a centrifugal round type cartridge which can be withdrawn by a centrifugal separator. The method according to claim 1,
Wherein the at least two of the circular type cartridge receiving housings are installed in one external housing in the y direction and are independently operable from the one external housing. 13. The method of claim 12,
The Z-axis driving section, the measuring section unit, and the tip ascending / descent opening section so that at least one of the Z-axis driving section, the measuring section unit, and the tip ascending / A modular automatic analyzer using a centrifugable circular type cartridge, wherein at least one of the cartridges is coupled to a Y-axis direction transfer unit movable in the y-axis direction. A centrifugal separable well mounted on top of the circular type cartridge receiving housing for centrifugation of the sample and at least two wells for performing a test on the sample in a rotational type. 15. The method of claim 14,
Wherein at least one pair of coupling grooves are formed in the center hole of the circular type cartridge at positions opposing to each other for engaging with the fan unit and an automatic analysis process is performed on the outside of the coupling groove in the radial direction by movement of the at least two wells And a origin display section for indicating a starting point of the centrifugal separator. 16. The method of claim 15,
Wherein the centrifugal well is formed to protrude in the direction of centrifugal force and covers the opening of the centrifugal well and includes a thin cap through which the tip can penetrate in accordance with movement of the tip ascending /

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