CN212031501U

CN212031501U - Reagent strip and reagent strip rotating table for reagent strip

Info

Publication number: CN212031501U
Application number: CN202020671154.4U
Authority: CN
Inventors: 吴勇; 严志伟; 李颖; 胡恒龙
Original assignee: Shijiazhuang Dihong Biotechnology Co ltd; Zhongshan Taihui Biotechnology Co ltd; Shanghai Taihui Biotechnology Co ltd
Current assignee: Shanghai Taihui Biotechnology Co ltd; Shijiazhuang Dihong Biotechnology Co ltd
Priority date: 2020-04-28
Filing date: 2020-04-28
Publication date: 2020-11-27
Anticipated expiration: 2030-04-28

Abstract

The utility model mainly relates to a reagent strip, reagent strip includes: a reagent strip body comprising a chamber portion and an opening above the chamber portion, the chamber portion having a non-recessed portion and at least one recessed portion, the recessed portion forming a reaction cup location to receive a reaction cup, the non-recessed portion comprising at least one interior chamber, the opening comprising at least one first opening corresponding to the at least one interior chamber; transparent reaction cups, the number of the reaction cups is consistent with the number of the concave parts, and the reaction cups are detachably or non-detachably mounted to the concave parts. The utility model discloses still relate to a reagent strip rotates platform for reagent strip. According to the utility model discloses a reagent strip and reagent strip revolving stage can be used for providing chemiluminescence project and the light excitation chemiluminescence project detection for the sample that awaits measuring that holds in the reaction cup of reagent strip under the condition that provides the light intensity condition.

Description

Reagent strip and reagent strip rotating table for reagent strip

Technical Field

The present disclosure relates generally to the field of in vitro diagnostic test immunoassays, and more particularly, to a reagent strip and a reagent strip carousel for a reagent strip.

Background

C-reactive protein (CRP), Serum Amyloid A (SAA), Procalcitonin (PCT) are the main basis for experimental examination of infectious diseases, and are used for diagnosis and identification of infection. CRP and SAA are mainly detected and analyzed by an immune turbidimetric method at present, and PCT with high sensitivity is mainly detected and analyzed by heterogeneous methods such as chemiluminescence and the like. The two detection methods have completely different detection principles, and the existing detection system has a single detection mode, so that samples need to be detected by aiming at different detection methods, thereby causing higher input time and equipment cost and lower detection efficiency.

At present, when semi-automatic or full-automatic chemiluminescence or light-activated chemiluminescence immunoassay is performed, a reaction cup strip type reagent strip is used for containing a sample to be detected, and a plurality of human detection reagents are respectively placed in different reagent chambers of the reagent strip. In this case, when a batch of samples to be detected is detected, the sample injection needle needs to repeatedly suck the required reagent, which may cause mutual contamination between reagents or samples. In addition, it is difficult for a large-sized instrument using such a reagent strip to achieve the purpose of "point-of-care testing" (POCT), which is a testing method in which analysis is performed immediately at a sampling site and a test result is obtained quickly.

CN107356587A discloses a light-activated chemiluminescent instant detection system, wherein the disclosed reagent strip comprises a plurality of functional separation sites. In the detection system, the excitation light source and the detector need to move in the vertical direction, so that the reagent strips positioned in the reagent box platform are sequentially subjected to light-tight detection by matching with the movement of the reagent box platform. When the detection is carried out, the excitation light source and the detector need to move up and down once in the vertical direction when detecting one sample, and the operation is complex and time-consuming.

SUMMERY OF THE UTILITY MODEL

It is an object of the present disclosure to provide a reagent strip and a reagent strip rotation station for a reagent strip that overcome at least one of the deficiencies of the prior art.

The utility model mainly relates to a reagent strip, reagent strip includes:

a reagent strip body comprising a chamber portion and an opening above the chamber portion, the chamber portion having a non-recessed portion and at least one recessed portion, the recessed portion forming a reaction cup location to receive a reaction cup, the non-recessed portion comprising at least one interior chamber, the opening comprising at least one first opening corresponding to the at least one interior chamber;

transparent reaction cups, the number of the reaction cups is consistent with the number of the concave parts, and the reaction cups are detachably or non-detachably mounted to the concave parts.

According to the utility model discloses a reagent strip is under the condition that provides the light density condition, can provide chemiluminescence project and the light-activated chemiluminescence project detection for the sample that awaits measuring that holds in the reaction cup of reagent strip.

In some embodiments, the notch portion is located at an end of the reagent strip body, or an intermediate region between the ends, in the lateral direction.

In some embodiments, the opening further comprises at least one second opening located above the at least one recess, the second opening forming a through-hole through the opening such that the reaction cup can be mounted into the recess through the second opening.

In some embodiments, the reaction cup has a circumferential flange extending radially outward along its opening such that the circumferential flange is capable of resting on the opening.

In some embodiments, the at least one first opening is a plurality of first openings, and the shapes of the plurality of first openings are the same as or different from each other.

In some embodiments, the at least one first opening and the second opening are shaped differently from each other.

In some embodiments, the reaction cup is mounted to the recess by means of a form fit or a snap connection.

In some embodiments, the reaction cup is mounted to the notch portion in a front-rear direction or a left-right direction of the reagent strip.

In some embodiments, the at least one first opening is provided with a vertical rim around its circumference.

In some embodiments, the one or more internal chambers comprise a reagent chamber configured to contain a reagent.

In some embodiments, the one or more internal chambers further comprise a suction head chamber configured to house a suction head.

In some embodiments, the number of reagent chambers is three, the number of pipetting head chambers is one, and the number of reaction cup locations is one.

In some embodiments, the reaction cup is a cuvette.

In some embodiments, the reaction cup is rectangular in cross-section.

In some embodiments, the reagent strip body is provided with a two-dimensional code on its outer wall.

In some embodiments, the two-dimensional code includes project information, calibration information, and/or production information.

In some embodiments, the reagent strip has an arcuate cross-section.

In some embodiments, the arc is no greater than 30 °.

In some embodiments, the reagent strip further comprises an encapsulation layer encapsulating the at least one first opening.

According to another aspect of the present invention, a reagent strip is provided, comprising:

a reagent strip body comprising a chamber portion and an opening portion above the chamber portion, the chamber portion comprising at least one interior chamber, the opening portion comprising at least one first opening corresponding to the at least one interior chamber;

a transparent reaction cup removably or non-removably mounted to a sidewall of the reagent strip body.

In some embodiments, the reagent strip body and the reaction cup are removably connected together by a form fit or snap connection.

In some embodiments, the reagent strip carousel is generally annular and includes a rotating disk provided with a plurality of reagent strip holders in a circumferential direction, the reagent strip holders being configured to accommodate the reagent strips according to the previous embodiments, and a cover, wherein the cover is capable of covering the rotating disk and providing a dark room environment for the test strips.

In some embodiments, the reagent strip holders are adjacent to each other in the circumferential direction of the rotary disk, or spaced apart in the circumferential direction of the rotary disk.

In some embodiments, the reagent strip holders are equally or unequally spaced apart in the circumferential direction of the rotating disk.

In some embodiments, the number of reagent strip holders is 12.

Additional features and advantages of the disclosed subject technology will be set forth in the description which follows, and in part will be obvious from the description, or may be learned by practice of the disclosed subject technology. The advantages of the subject technology of the present disclosure will be realized and attained by the structure particularly pointed out in the written description and claims hereof as well as the appended drawings.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the subject technology of the present disclosure as claimed.

Drawings

In order to more clearly illustrate the embodiments of the present invention or the technical solutions in the prior art, the drawings needed to be used in the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and for those skilled in the art, other drawings can be obtained according to these drawings without inventive labor.

FIG. 1 is a schematic diagram of a reagent strip according to an embodiment of the present invention;

FIG. 2 is an exploded schematic view of a variation of the embodiment of the reagent strip of FIG. 1;

fig. 3 is a schematic structural diagram of a reagent strip rotating table for reagent strips according to the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the embodiments of the present invention clearer, the embodiments of the present invention will be clearly and completely described below with reference to the accompanying drawings in the embodiments of the present invention, and it is obvious that the described embodiments are some, but not all, embodiments of the present invention. Based on the embodiments in the present invention, all other embodiments obtained by a person skilled in the art without creative efforts belong to the protection scope of the present invention.

The technical solution of the present invention will be described in detail with specific examples. The following several specific embodiments may be combined with each other, and details of the same or similar concepts or processes may not be repeated in some embodiments.

For convenience of description, a direction parallel to the direction of gravity is defined as a vertical direction, a direction parallel to a light beam path used in the immunoturbidimetric assay is defined as a front-rear direction, and a direction perpendicular to both the vertical direction and the front-rear direction is defined as a lateral direction.

Fig. 1 and 2 show an assembled perspective view and an exploded perspective view of a reagent strip 1 according to an embodiment of the present invention. The reagent strip 1 can be used for immunoturbidimetric assay and/or chemiluminescent immunoassay and/or light-activated chemiluminescent immunoassay. As shown in the figure, the reagent strip 1 is generally cylindrical and includes a reagent strip body 10, and a reaction cup 20 detachably or non-detachably mounted on the reagent strip body 10. The reaction cup 20 is used for accommodating a reagent to be detected, and the reagent strip body 10 is used for accommodating a reagent, a solvent and/or a component (e.g., a suction head of a pipetting device) and the like required for detection.

The reaction cup 20 is transparent so that an optical signal can sequentially pass through one side and the inside of the reaction cup 20 and pass through the other side of the reaction cup 20. In some embodiments, reaction cup 20 is a cuvette.

The reagent strip body 10 includes an opening 11 and a chamber 12. The opening 11 provides external access to the chamber portion 12 and the reaction cup 20, while the chamber portion 12 is used to receive and contain reagents, solvents and/or components from the opening 11. The opening 11 and the chamber 12 are integrally formed.

The chamber portion 12 has a notch 13 penetrating the front-rear direction at one side portion in the lateral direction thereof, and the notch 13 divides the reagent strip body 10 into a notch portion 14 and a non-notch portion 15. The recess portion 14 forms a reaction cup position for accommodating a reaction cup 20. It is understood that in other embodiments, the notch portion 14 may also be disposed in an intermediate region between the two ends of the chamber portion 12 in the lateral direction. The non-recessed portion 15 is provided with one or more internal chambers for receiving and containing reagents, solvents and/or components, such as a reagent chamber 32 for receiving and containing reagents and a pipetting head chamber 33 for receiving and containing a pipetting head of a pipetting device, and the like. The reagent includes, for example, an immunoturbidimetric assay reagent, a chemiluminescent assay reagent, a diluent, a buffer solution, etc. Alternatively, after the pipette tip and the reagent are loaded into the pipette tip chamber 33 and the reagent chamber 32, respectively, the pipette tip chamber 33 and the reagent chamber 32 may be sealed with a sealing layer such as a disposable sealing film or a foil paper.

The opening portion 11 extends over the notched portion 14 and the non-notched portion 15. The opening 11 is formed with a plurality of openings including, for example, a cuvette opening 21, a reagent chamber opening 22, a suction head chamber opening 23, and the like. The cuvette opening 21 is for access to the cuvette 20 below, the reagent chamber opening 22 is for access to the reagent chamber 32 below, and the pipetting head chamber opening 23 is for access to the pipetting head chamber 33 below. This embodiment comprises one reaction cup opening 21, three reagent chamber openings 22 and one pipetting head chamber opening 23. It is understood that other embodiments may have other numbers of reaction cup openings 21, reagent chamber openings 22, and suction head chamber openings 23, with chamber portion 12 forming correspondingly other numbers of reaction cup locations, reagent chambers 32, and suction head chambers 33. In some embodiments, the reagent strip body 10 may also omit the pipette tip compartment opening 23 and pipette tip compartment 33.

The cuvette opening 21 is located above the notch portion 14, and the reagent chamber opening 22 and the suction head chamber opening 23 are located above the non-notch portion 15, specifically the reagent chamber opening 22 and the suction head chamber opening 23 are located above the reagent chamber 32 and the suction head chamber 33, respectively. In some embodiments, a vertical rim is provided around the periphery of the reagent chamber opening 22 and/or the pipetting head chamber opening 23 to reduce spillage of the contents of the reagent chamber 32 and/or the pipetting head chamber 33, for example due to shaking.

In some embodiments, the cuvette opening 21 is formed as a through-hole penetrating the opening 11 for the cuvette 20 to pass through from the top to the bottom, thereby mounting the cuvette 20 in the cuvette site. In other embodiments, reaction cup 20 may have a circumferential flange extending radially outward along its own opening, such that the flange is able to rest on opening 11.

In other embodiments, the reaction cup 20 may be fixedly or detachably mounted on the reaction cup position from one side of the reagent strip body 10 in the front-rear direction or one side of the left-right direction. For example, the reaction cup 20 may be fixedly mounted on the reaction cup position by bonding. For example, reaction cup 20 may be removably mounted to the reaction cup site by a form fit or snap fit connection. FIG. 2 shows an example of detachable mounting of the reaction cup 20 and the reagent strip body 10. The reaction cup 20 and the side surface of the notch part 14 of the reagent strip body 10 are provided with a groove 141 and a protrusion 142, respectively, so that the reaction cup 20 can be mounted on the reagent strip body 10 by a form fit. It is understood that in other embodiments, the groove 141 and the protrusion 142 for shape fitting may be provided at different positions from the illustrated positions, for example, on the bottom of the notch part 14 and the reaction cup 20.

The cuvette opening 21, the reagent chamber opening 22 and the pipette tip chamber opening 23 may have different shapes, respectively, in order to distinguish between the packaging and/or use of the respective function compartments. For example, in the present embodiment, the suction head chamber opening 23 has an elliptical shape, and the reagent chamber opening 22 has a circular shape. The cross-sections of the cuvette opening 21 and the cuvette 20 are rectangular, so that the path of the light remains unchanged even if a certain positional deviation occurs after the rotating disk containing the reagent strip 1 is repeatedly operated a number of times. It should be understood that each opening may have various other shapes as well.

The reagent strip body 10 can be made of non-absorbent polymer material and can be formed by injection molding. The nonabsorbing polymer material may be polymethyl methacrylate or polypropylene. The reaction cup 20 may be made of optical glass.

In some embodiments, the volume of the reagent chamber 32 is 50 μ L to 800 μ L, preferably 50 μ L to 200 μ L, and more preferably 50 μ L to 100 μ L. In some embodiments, the reaction cup 20 has a capacity of 100 μ L to 1000 μ L, preferably 100 μ L to 500 μ L, and more preferably 100 μ L to 300 μ L. In some embodiments, the volume of the pipette tip enclosed in the pipette tip compartment 33 is 20 μ L to 200 μ L.

In other embodiments not shown, the opening 11 may extend only above the non-recessed portion 15, such that there is no reaction cup opening 21. The reaction cup 20 is fixedly attached (e.g., by bonding) to the notch portion 14 of the reagent strip body 1, or detachably attached to the notch portion 14 by means of form-fitting, snap-fitting, or the like.

In other embodiments, not shown, the reagent strip includes a reagent strip body having a generally cylindrical shape and a reaction cup. The reagent strip body does not have the notch and notch portion as shown in FIG. 1, but is fixedly (e.g., by bonding) or detachably connected to the reaction cup through its side surface. In some embodiments, the reagent strip body and the reaction cup have a shape-fitting portion or a snap portion on side surfaces thereof, respectively, for detachably connecting the reagent strip body and the reaction cup.

In some embodiments, the reagent strip 1 is generally arcuate in cross-section and is designed to fit the dimensions of the test instrument. Optionally, the arc of the strip 1 is no more than 30 °, preferably 10 °, 15 ° or 30 °. In some embodiments, the arc of the strip 1 is 30 °.

In some embodiments, the reagent strip body 10 may be provided with a two-dimensional code on its outer wall, the two-dimensional code containing reagent strip information. The reagent strip information may include project information, calibration information, date of manufacture, etc. The two-dimensional code may be disposed on the front wall, rear wall, or side wall of the reagent strip body 10.

FIG. 3 shows a reagent strip rotation station 4 according to one embodiment of the present disclosure. The reagent strip rotation table 4 is substantially annular and is used for moving one or more reagent strips 1 in a rotating manner. As shown, the reagent strip rotation table 4 includes a rotation disk 41 and a cover 42. The rotary disk 41 is provided with a plurality of reagent strip holders 43 in the circumferential direction thereof for accommodating the reagent strips 1. The cover body 42 is adapted to the rotary disk 41 so that the cover body 42 can cover the rotary disk 41 and can completely cover the reagent strip seats 43 to provide a dark room environment for the reagent strips 1 accommodated in the rotary disk 41. The reagent strip holders 43 may abut each other in the circumferential direction of the rotary disk 41, may be equally spaced or not equally spaced in the circumferential direction of the rotary disk 41. The number of reagent strip holders 43 may be set as desired. In some embodiments, the number of reagent strip holders 43 is twelve to meet both basic testing needs and portability.

According to the utility model discloses a reagent strip 1 and reagent strip revolving stage 4 can provide chemiluminescence project and the light excitation chemiluminescence project detection for the sample that awaits measuring that holds in the reaction cup 20 of reagent strip 1 under the condition that provides the light intensity condition. Because the reaction cup 20 on the reagent strip 1 can allow the optical signal to pass through one side and the inside of the reaction cup and pass through from the opposite side, the reagent strip 1 and the reagent strip rotating table 4 according to the embodiment of the present invention can also be applied to the detection of the immunoturbidimetric project. Therefore, when a combined detection reagent of immunoturbidimetry detection, chemiluminescence detection, and light-activated chemiluminescence detection is used in combination, it is possible to perform tests for at least two items in the same reagent strip 1.

According to the utility model discloses a reaction cup 20 of reagent strip 1 of some embodiments can be dismantled to can only need to change reaction cup 20 and can continue to use, with sparingly economic cost.

Finally, it should be noted that: the above embodiments are only used to illustrate the technical solution of the present invention, and not to limit the same; although the present invention has been described in detail with reference to the foregoing embodiments, it should be understood by those skilled in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some or all of the technical features may be equivalently replaced; such modifications and substitutions do not depart from the spirit and scope of the present invention.

Claims

1. A reagent strip, comprising:

2. The reagent strip of claim 1 wherein the notch portion is located at an end of the reagent strip body, or an intermediate region between the ends, in the transverse direction.

3. The reagent strip of claim 1 wherein the opening further comprises at least one second opening positioned above the at least one notch, the second opening forming a through-hole through the opening such that the reaction cup can fit into the notch through the second opening.

4. The reagent strip of claim 3 wherein the reaction cup has a radially outwardly extending circumferential flange along its opening such that the circumferential flange can rest on the opening.

5. The reagent strip of claim 3, wherein the at least one first opening is a plurality of first openings, and the plurality of first openings are the same or different shapes from each other.

6. The reagent strip of claim 3 wherein the at least one first opening and the second opening are shaped differently from one another.

7. The reagent strip of claim 1, wherein the reaction cup is mounted to the notch portion by a form fit or a snap fit connection.

8. The reagent strip of claim 6, wherein the reaction cup is mounted to the notch portion in a front-rear direction or a left-right direction of the reagent strip.

9. The reagent strip of claim 1 wherein the at least one first opening is provided with a vertical rim around its periphery.

10. The reagent strip of claim 1, wherein the one or more internal chambers comprise a reagent chamber configured to contain a reagent.

11. The reagent strip of claim 10 wherein the one or more internal chambers further comprise a pipetting tip compartment configured to receive a pipetting tip.

12. The reagent strip of claim 11, wherein the number of reagent chambers is three, the number of pipetting head chambers is one, and the number of reaction cup locations is one.

13. The reagent strip of claim 1 wherein the reaction cup is a cuvette.

14. The reagent strip of claim 1, wherein the reaction cup is rectangular in cross-section.

15. The reagent strip of claim 1, wherein the reagent strip body is provided with a two-dimensional code on an outer wall thereof.

16. The reagent strip of claim 15, wherein the two-dimensional code comprises project information, calibration information, and/or production information.

17. The reagent strip of claim 1, wherein the reagent strip has an arcuate cross-section.

18. The reagent strip of claim 17 wherein the arc of the arc is no greater than 30 °.

19. The reagent strip of claim 1 further comprising an encapsulation layer encapsulating the at least one first opening.

20. A reagent strip, comprising:

21. The reagent strip of claim 20, wherein the reagent strip body and the reaction cup are removably connected together by a form fit or snap connection.

22. A reagent strip carousel for reagent strips comprising a carousel provided with a plurality of reagent strip holders in a circumferential direction configured to accommodate reagent strips according to any one of claims 1 to 21, and a cover, wherein the cover is adapted to cover the carousel and provide a dark room environment for the reagent strips.

23. The reagent strip carousel of claim 22 wherein the reagent strip seats are adjacent to each other in the circumferential direction of the rotating disk or are spaced apart in the circumferential direction of the rotating disk.

24. The reagent strip carousel of claim 23 wherein the reagent strip holders are equally or unequally spaced apart in a circumferential direction of the rotating disk.

25. The reagent strip carousel of claim 22 wherein the number of reagent strip holders is 12.