KR20180105798A - Allergic diseases patient-specific environment management system - Google Patents

Abstract

The present invention provides an allergic disease patient-customized environment integrated management system which promotes effective treatment and management of an allergic disease and further minimizes an allergy march. According to an embodiment of the present invention, the system comprises: a user device for receiving medical information of an allergic disease patient, or providing behavioral guidance information according to an environment of the patient; an environment information collecting device for collecting information on a surrounding environment of the patient; and an analysis device for determining patient-customized behavioral guidance information based on the medical information of the patient and the collected environment information. The user device can include a control part which operates the other device connected to the system in order to improve the surrounding environment of the patient according to a result of the analysis device or causes the user device to output the behavioral guidance information.

Description

{ALLERGIC DISEASES PATIENT-SPECIFIC ENVIRONMENT MANAGEMENT SYSTEM}

The present invention relates to a personalized environment integrated management system for an allergic disease patient.

Allergic diseases (eg, atopic dermatitis, asthma, etc.) are chronic diseases, and after clinical symptoms of atopic dermatitis develop in infants and young children, they gradually show asthma and allergic rhinitis. It has a profound effect and causes a lot of social costs, so it is a disease that requires active treatment and management.

Allergic diseases such as atopic dermatitis and asthma are influenced by indoor and outdoor environmental factors in addition to individual biological factors. In particular, the recent deterioration of living environment such as climate change, dustiness, and fine dust generation is seriously affecting people with disease, so thorough environmental management is needed.

Recently, a personalized environmental factor monitoring device has been developed that combines a sensor for detecting the indoor environment factor and the Internet (IoT) technology. However, until now, the device has been manufactured for a healthy general person, It remains at a level that allows simple measurements and display of results without algorithms for disease-specific management. There is no indoor environment measurement and management monitoring system optimized for allergy sufferers yet.

Even if a reliable environmental harmful factor sensor is developed and used, it is very difficult for the patient to judge the result of the measurement himself or to understand the causal relationship between the symptom and the environmental factor of the patient and to control the environment or manage the disease. Therefore, it is necessary to overcome these limitations and to treat allergic diseases through an environment-disease management system that enables two-way communication between patients and medical staff. However, there has not been developed a customized environment management system for allergy patients.

1. Korean Registered Patent No. 1543190 (registered on August 03, 2015)

The present invention aims at constructing a system that provides optimal environmental management and disease management guidelines for allergy sufferers by comprehensively analyzing biological information of a patient, environmental information of a patient, behavior of a patient, and disease characteristic information. Through this system, it is ultimately aimed at effective treatment and management of allergic diseases and further minimizing allergy march.

As an embodiment of the present invention, an integrated environment management system customized for patients with allergic diseases can be provided.

The integrated environment management system customized for an allergic disease patient according to an embodiment of the present invention includes a user device for receiving medical information of an allergic disease patient or providing behavioral guidance information according to the environment of a patient, And an analysis device for determining patient-specific behavioral guidance information based on the patient's medical information and the collected environmental information, wherein the user device is provided with an improvement device And a control unit for causing the user device to output the action instruction information.

In addition, the medical information of the patient includes the biological information of the patient and the disease-related information, and the disease-related information of the patient can be collected by inputting from the patient through the user device in real time or at predetermined time intervals.

The indoor environment information collecting unit includes an indoor environment information collecting unit and an outdoor environment information collecting unit. The indoor environment information collecting unit collects indoor environmental information from at least one sensor module installed in the living space of the patient, And the outdoor environment information collecting unit can collect outdoor environmental information in real time from at least one sensor module installed in an external measuring station adjacent to the living space of the patient.

In the analyzing apparatus according to an embodiment of the present invention, a causal relationship between the environmental harmful factor and allergic disease symptoms is analyzed for each patient by applying a generalized linear model, and based on the result of the analysis, Action instruction information can be determined.

The causal relationship between the environmentally harmful factor and the symptoms of the allergic disease according to one embodiment of the present invention is a result of the indoor air quality and the indoor air quality, Can be analyzed as substantial exposure.

In addition, the controller according to an embodiment of the present invention may transmit the analysis result from the analyzing device to an external device connected to the system through the communication device of the system, or may receive environmental management recommendation information from the external device.

As an embodiment of the present invention, an environmental management method using an integrated environment management system customized for an allergic disease patient can be provided. A method according to an embodiment of the present invention includes the steps of receiving medical information of an allergic disease patient, collecting information on the surrounding environment of the patient, and collecting information on the patient- And other devices connected to the system may be operated to improve the environment of the patient according to the result of the determination, or behavioral direction information may be provided to the patient.

Meanwhile, as an embodiment of the present invention, a computer-readable recording medium on which a program for causing the computer to execute the above-described method may be provided.

The system according to an embodiment of the present invention can be effectively used in healthcare institutions such as hospitals and clinics for the treatment and management of allergic diseases such as asthma and atopic dermatitis.

In addition, the system configuration and operation principle can be applied not only to allergic diseases but also to the management of chronic diseases that are directly affected by the indoor and outdoor environment, and the user can use the smart home networking function, environmental measurement sensor, And the disease can be managed at all times. In addition, the system can be used for other diseases other than allergic diseases.

Based on the analysis results using the system according to an embodiment of the present invention, it is possible to adopt the evidence-based treatment strategy by establishing the basis for indoor air quality management of allergy sufferers and further establish the basis of personalized precision treatment for allergic diseases can do.

In addition, since the disease management platform utilizing the sensor-based environmental monitoring and control technology can be applied to other environmental diseases (for example, respiratory diseases, cardiovascular diseases, multiple chemical sensitivity (MCS), etc.) The scope of application is excellent.

In future, sensitivity of patients including genotypes and exposure to indoors and outdoors living environments will enable correlation analysis and genetic - environmental interaction studies, and it will be possible to establish personalized preventive treatment strategy that is more advanced than current level.

The air quality management sensor, IoT-based data transmission, algorithm and solution technology for air quality management, and bidirectional communication function applied to the living environment management platform of the system according to the embodiment of the present invention, It can be a basis for establishing a healthy home for general health care as well as digital healthcare technology.

FIG. 1 shows a personalized environment integrated management system for an allergic disease patient according to an embodiment of the present invention.
2 is an example of an operation screen of a user device according to an embodiment of the present invention.
FIG. 3 is a flowchart illustrating an environmental management method using an integrated environment management system customized for an allergic disease patient according to an embodiment of the present invention. Referring to FIG.
4 is an example of an environmental solution derivation using a unique algorithm according to an embodiment of the present invention.

Hereinafter, embodiments of the present invention will be described in detail with reference to the accompanying drawings, which will be readily apparent to those skilled in the art. The present invention may, however, be embodied in many different forms and should not be construed as limited to the embodiments set forth herein. In order to clearly illustrate the present invention, parts not related to the description are omitted, and similar parts are denoted by like reference characters throughout the specification.

The terms used in this specification will be briefly described and the present invention will be described in detail.

While the present invention has been described in connection with what is presently considered to be the most practical and preferred embodiment, it is to be understood that the invention is not limited to the disclosed embodiments. Also, in certain cases, there may be a term selected arbitrarily by the applicant, in which case the meaning thereof will be described in detail in the description of the corresponding invention. Therefore, the term used in the present invention should be defined based on the meaning of the term, not on the name of a simple term, but on the entire contents of the present invention.

When an element is referred to as "including" an element throughout the specification, it is to be understood that the element may include other elements as well, without departing from the spirit or scope of the present invention. Also, the terms "part," " module, "and the like described in the specification mean units for processing at least one function or operation, which may be implemented in hardware or software or a combination of hardware and software . In addition, when a part is referred to as being "connected" to another part throughout the specification, it includes not only "directly connected" but also "connected with other part in between".

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Hereinafter, the present invention will be described in detail with reference to the accompanying drawings.

FIG. 1 shows a personalized environment integrated management system for an allergic disease patient according to an embodiment of the present invention. FIG. 2 is an example of an operation screen of a user device according to an embodiment of the present invention, and FIG. 4 is an example of an environment solution derivation using a unique algorithm according to an embodiment of the present invention.

The integrated environment management system 1000 according to an embodiment of the present invention includes a user device 100 for receiving medical information of an allergic disease patient or providing behavioral guidance information according to a patient's environment, An environment information collecting device 200 for collecting information on the surrounding environment, and an analyzing device 300 for determining patient-specific action instruction information based on the patient's medical information and the collected environment information, 100 may include a control unit for operating the other device 400 connected to the system to improve the surrounding environment of the patient according to the result of the analysis apparatus or for causing the user device to output the action instruction information.

In addition, the medical information of the patient includes the biological information of the patient and the disease-related information, and the disease-related information of the patient can be collected by inputting from the patient through the user device in real time or at predetermined time intervals. The predetermined time interval may be, for example, 1 hour, 3 hours, 6 hours, or the like, and may be determined differently depending on the age, disease type, severity, etc. of the patient.

(For example, sex, age, family history, etc.), disease information (for example, severity), etc., which can be provided to the medical institution by registering with the medical institution such as a hospital, To the medical institution.

The user device 100 may be a PC, a smart phone, a tablet PC, a laptop or a portable display device capable of wireless or wired communication with an external device 400 such as a server provided in a medical institution or the like, a medical device A wearable device such as a watch, and the like, but the present invention is not limited thereto. In addition, the user device 100 may receive an image or the like containing medical data or the like provided from the analyzing device 300, display it through a display unit provided in the user device 100, or store and manage the received image by itself . In addition, the user device 100 can transmit or receive various data through a communication module or the like to a server provided in a remote medical institution or the like. A server according to an exemplary embodiment of the present invention includes at least one of a Picture Archiving and Communication System (PACS), an Electronic Medical Record (EMR), a Personal Health Record (PHR), and a Radiology Information System can do.

As shown in FIG. 2 (a), the user can input his / her daily symptom score and time activity pattern at a predetermined time interval through the user device 100, A server such as an analyzer 300, and the like. The predetermined time interval may be, for example, 1 hour, 3 hours, 6 hours, etc., and may be determined differently depending on the age, disease type, severity, etc. of the patient.

The indoor environment information collecting unit 210 includes an indoor environment information collecting unit 210 and an outdoor environment information collecting unit 220. The indoor environment information collecting unit 210 collects indoor environmental information The outdoor environment information collecting unit 220 collects outdoor environmental information from at least one sensor module installed in an external measuring station adjacent to the patient's living space in real time Can be collected.

For example, at least one sensor may be installed in advance in a home where the patient lives, and the information collected through the sensor may be transmitted to the medical center through a local communication (for example, Bluetooth or the like) A server of an institution, an analysis apparatus 300, and the like. Information can be collected in real time through the sensor, and measurement items can be fine dust concentration, VOCs, temperature, humidity, and the like.

The outdoor environment information collecting unit 220 according to an embodiment of the present invention may be installed in an external measuring site adjacent to a residence (for example, a home, etc.) of the patient. In addition, the information collected through the outdoor environment information collecting unit 220 may be provided in real time (e.g., air pollution monitoring network data, etc.) through a network of a government office (e.g., the Ministry of Environment). The user can input residence information through his / her user device 100. [ The nearest external measurement site is determined according to the inputted settlement site information, and information measured from the external measurement site can be provided to the user device 100 and the analysis apparatus 300. Items of information to be collected through the outdoor environment information collecting unit 220 is fine dust (PM10, PM2.5), nitrogen dioxide (NO2), sulfur dioxide (SO2), ozone (O _3), be the concentration of carbon monoxide (CO) .

In the analysis apparatus 300 according to an embodiment of the present invention, a causal relationship between environmental harmful factors and allergic disease symptoms is analyzed for each patient by applying a generalized linear model, and based on the results of the analysis, Patient-specific behavioral guidance information can be determined.

The causal relationship between the environmentally harmful factor and the symptoms of the allergic disease according to one embodiment of the present invention is a result of the indoor air quality and the indoor air quality, Can be analyzed as substantial exposure.

According to an embodiment of the present invention, the analytical device 300 can identify a cause-and-effect relationship between an environmental harmful factor and an allergic disease symptom by analyzing a patient by applying a statistical model. In this case, the exposure of the environment-related harmful factor to the indoor air quality of the user is evaluated based on the indoor air quality and indoor air quality based on the results of indoor monitoring using sensors and sensors, The causal relationship can be analyzed using exposure, ie, Time Weighted Average (TWA) concentration. In addition, the analyzing apparatus 300 analyzes the input information (e.g., patient's personal information, location information, indoor / outdoor environmental monitoring information, clinical monitoring information, etc.) Algorithm can be used.

Algorithms for providing patient-specific behavioral guidance can be changed by the indoor / outdoor air pollutant items that can be measured through the sensor, but the temperature, humidity, fine dust (PM ₁₀ ), nitrogen dioxide (NO ₂ ) , And ozone (O ₃ ) are described as follows.

(Eg, temperature, humidity, CO ₂ , fine dust, VOCs), outdoor environmental information (eg, temperature, humidity, CO ₂ , fine dust, NO ₂ , O ₃ , SO ₂ , CO), a time activity pattern (e.g., location information of the user), and the like. These risk factors may also be pre-collected along with basic information of the user (e.g., key, weight, age, address, school, etc.) and symptom information (e.g., sleep disorder, itching, (300) or the like.

The OR and P-value for each risk factor can be calculated, and the RFs satisfying both the OR and P-value conditions can be determined as the risk factor inherent to the patient. For example, risk factor determinations are based on the results of exposure assessment of indoor and outdoor environmental risk factors and daily symptom analysis, and the items with odds ratio (OR) greater than 1 and P-value less than 0.05 It is judged as a risk factor. However, regarding temperature and humidity, it is considered to be a risk factor if the P-value is less than 0.05 regardless of the odds ratio. Here, OR is a factor that indicates how much more dangerous the risk factor is when it is lower. That is, it can mean the relative increase in the risk ratio. Also, the P-value indicates the reliability of the OR result, and the lower the P-value, the more reliable the OR. In other words, when the OR is more than a certain value (for example, 1) and the P-value is low (for example, less than 95%, 0.05), the risk factor can be determined as a specific risk factor of the target patient. Risk factors that do not meet the OR and P-value conditions at the same time are not considered in the patient.

Each patient may have different effects on environmental risk factors, and the patient may respond to one, two, three, four, or five risk factors. The risk factor (RF) to be applied to the statistical model can be the basis of the OR, P-value calculation as described above. The statistical model can be applied to a generalized linear model for data analysis, and to a statistical analysis model using Time Weighted Average (TWA) concentration for risk factors that can be simultaneously measured indoors and outdoors . The solution code can be determined by combining risk factors based on the calculated OR and P-value. Such a solution code may be predefined and stored in the analysis device 300 or the like as a code for providing a patient-specific behavioral guidance. For example, if one of the risk factors is sensitive and the room temperature is above 26 ° C (° C), the solution code 0101001 is determined for the patient and the patient-customized action guidelines (eg, indoor cooling) have. Such behavioral guidance may be provided as a behavioral guide in at least one of indoor and outdoor. And may be selectively provided according to the preference of the user (for example, providing only a behavior guide in the room).

Alarms and action guidelines can be delivered in accordance with the criteria set out in the following Table 1 for the exposure status of each environmental risk measured in real time. Table 1 shows an example of the alarm criteria by environmental risk factors. The reference value for alarms may vary depending on future environmental changes and individual analysis results.

Once the patient's unique risk factors are determined, the behavioral guidance solution can be determined by being integrated with the patient's biometric information and daily collection information, and alert and behavioral guidance can be provided to the patient according to the determined solution. For example, if patient-specific sensitivities are determined and the exposure environment requires an alert, a total of 1,408 behavioral guidance solutions occur, taking into account the five risk factors and the indoor / outdoor conditions. An example of such a solution determination algorithm is as follows.

<Statistical Analysis Model for Determining Sensitive Risk Factors for Patient and Dance Type>:

Y _i : presence or absence of atopic dermatitis in patient i (0 or 1)

Temp _i : exposure temperature of patient i

RH _i : Exposure relative humidity of patient i

PM10 _i : Fine dust exposure concentration of patient i

NO2 _i : Exposure to nitrogen dioxide in patient i

O3 _i : Ozone exposure concentration of patient i

factor ( fever): presence or absence of fever (0 or 1)

factor ( TCS): whether to use topical corticosteroids (0 or 1)

: 각 위험요소에 대한 파라미터 값 (대상 환자의 신체 및 환경조건 등에 의하여 상이하게 결정될 수 있음)

: Parameter values for each risk factor (which may be differently determined by the patient's physical and environmental conditions)

: 오차 항

: Error term

The solution code is determined according to each situation, and the environment improvement action guide corresponding to the solution code is delivered to each patient. For example, the single risk factor is shown in Table 2 below. Table 2 shows examples of environmental improvement solutions (for example, when sensitive to a single risk factor) according to each environmental exposure situation.

In addition, the control unit according to an embodiment of the present invention allows the analysis result from the analysis apparatus to be transmitted to an external apparatus connected to the system 1000 through a communication apparatus (e.g., a wired / wireless communication module of the system) , And can receive environmental management recommendation information from an external apparatus. The external device may be a server built in a medical institution or the like or an electronic device capable of communicating with the user device 100 as described above. Electronic devices may include various sensors, home appliances, PCs, smart phones, tablet PCs, laptops, portable display devices, wearable devices such as smart watches, and the like. The above-described electronic device is merely an example, and is not necessarily limited thereto. In other words, the analysis result can be used not only as a personal device of a patient but also as a basis for controlling an Internet of things (IoT) device existing in a patient's home.

According to an embodiment of the present invention, a patient's life pattern is analyzed based on information collected during a predetermined period, a recommended behavior guide for each patient is determined according to the life pattern of the analyzed patient and the measured (monitored) environment information May be provided to the patient. For example, it is possible to reflect the characteristics of individual patients analyzed based on data collected over a minimum of 3 months, and to provide behavioral guidelines for individual patients based on indoor and outdoor environmental information and symptom information measured in real time Etc.) may be determined and provided to the patient.

This recommended behavioral guideline may be provided to the patient, at least one of which is the user, as in Figure 2 (b). The recommended behavioral guidance may be provided differently for each patient and may be provided in the form of a pop-up window on the screen of the user device 100, as in FIG. 2 (c). In addition, the recommended action instructions may also be provided in the form of a moving picture including not only a message such as text, but a sound such as an alarm, attitude information to be taken by the patient, and information on emergency action steps.

FIG. 3 is a flowchart illustrating an environmental management method using an integrated environment management system customized for an allergic disease patient according to an embodiment of the present invention. Referring to FIG.

A method for managing an environment using an integrated environment management system customized for an allergic disease patient according to an embodiment of the present invention includes a step (S100) of receiving medical information of an allergic disease patient, a step (S200) And determining (S300) patient-specific behavioral guidance information based on the patient's medical information and the collected environmental information, wherein the other device connected to the system is operated to improve the patient's environment according to a result of the determination , Behavioral guidance information may be provided to the patient (S400).

With respect to the method according to an embodiment of the present invention, the contents of the above-described system can be applied. Therefore, the description of the same contents as the above-mentioned system is omitted in connection with the method.

One embodiment of the present invention may also be embodied in the form of a recording medium including instructions executable by a computer, such as program modules, being executed by a computer. Computer readable media includes both non-volatile media, removable and non-removable media, which can be accessed by a computer. In addition, the computer readable medium may include both computer storage media. Computer storage media includes both non-volatile, removable and non-removable media implemented in any method or technology for storage of information such as computer readable instructions, data structures, program modules or other data.

It will be understood by those skilled in the art that the foregoing description of the present invention is for illustrative purposes only and that those of ordinary skill in the art can readily understand that various changes and modifications may be made without departing from the spirit or essential characteristics of the present invention. will be. It is therefore to be understood that the above-described embodiments are illustrative in all aspects and not restrictive. For example, each component described as a single entity may be distributed and implemented, and components described as being distributed may also be implemented in a combined form.

The scope of the present invention is defined by the appended claims rather than the detailed description and all changes or modifications derived from the meaning and scope of the claims and their equivalents are to be construed as being included within the scope of the present invention do.

100: User device
200: Environmental information collecting device
210: indoor environment information collecting unit
220: outdoor environment information collecting unit
300: Analyzer
400: other device
1000: Personalized environment management system for allergy patients

Claims (8)

As a personalized environment integrated management system for allergy patients,
A user device for inputting medical information of an allergic disease patient or providing behavioral guidance information according to the patient's environment;
An environment information collection device for collecting information on the environment of the patient; And
An analysis device for determining patient-specific behavioral guidance information based on the patient &apos; s medical information and the collected environmental information,
The user device includes a control unit for operating the other device connected to the system to improve the environment of the patient according to a result of the analyzing apparatus or for causing the user device to output the action instruction information Integrated environmental management system customized for patients with allergic diseases.
The method according to claim 1,
Wherein the medical information of the patient includes biological information and disease related information of the patient,
Wherein the disease related information of the patient is collected by being input from the patient through the user device in real time or at predetermined time intervals.
The method according to claim 1,
The environmental information collecting apparatus includes an indoor environment information collecting unit and an outdoor environment information collecting unit,
The indoor environment information collecting unit collects indoor environmental information from at least one sensor module installed in the living space of the patient in real time,
Wherein the outdoor environment information collecting unit collects outdoor environmental information in real time from at least one sensor module installed in an external measuring station adjacent to the living space of the patient.
The method according to claim 1,
The analysis apparatus analyzes a causal relationship between the environmental harmful factor and the symptoms of the allergic disease by applying a generalized linear model to each patient and determines patient-specific behavioral guidance information for the patient based on the result of the analysis Wherein the at least one of the at least two of the at least two of the at least one of the at least two of the at least one of the at least two of the at least one allergy patients.
5. The method of claim 4,
The causal relationship between the environmentally harmful factor and the allergic disease symptom is analyzed as the actual exposure level of the patient's environment based on the results of the indoor air quality and the outdoor air quality, Wherein said at least one of said at least one of said at least two of said at least two of said at least two of said at least one of said at least two of said at least one of
The method according to claim 1,
Wherein the controller transmits the analysis result from the analyzing device to an external device connected to the system through the communication device of the system or receives environmental management recommendation information from the external device. Management system.
As an environmental management method using an integrated environment management system customized for allergy patients,
Receiving medical information of an allergic disease patient;
Collecting information on the environment of the patient; And
Determining patient-specific behavioral guidance information based on the patient &apos; s medical information and the collected environmental information,
Wherein the other device connected to the system is operated to improve the environment of the patient according to a result of the determination, or the behavior instruction information is provided to the patient. How to manage.
A computer-readable recording medium having recorded thereon a program for implementing the method of claim 7.

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