KR20180084817A - Anti-SIGLEC-9 antibodies and methods of using the same - Google Patents
Anti-SIGLEC-9 antibodies and methods of using the same Download PDFInfo
- Publication number
- KR20180084817A KR20180084817A KR1020187014634A KR20187014634A KR20180084817A KR 20180084817 A KR20180084817 A KR 20180084817A KR 1020187014634 A KR1020187014634 A KR 1020187014634A KR 20187014634 A KR20187014634 A KR 20187014634A KR 20180084817 A KR20180084817 A KR 20180084817A
- Authority
- KR
- South Korea
- Prior art keywords
- siglec
- antibodies
- methods
- same
- Prior art date
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/75—Agonist effect on antigen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/577—Immunoassay; Biospecific binding assay; Materials therefor involving monoclonal antibodies binding reaction mechanisms characterised by the use of monoclonal antibodies; monoclonal antibodies per se are classified with their corresponding antigens
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Biomedical Technology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Endocrinology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201562248231P | 2015-10-29 | 2015-10-29 | |
US62/248,231 | 2015-10-29 | ||
PCT/US2016/059443 WO2017075432A2 (en) | 2015-10-29 | 2016-10-28 | Anti-siglec-9 antibodies and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
KR20180084817A true KR20180084817A (en) | 2018-07-25 |
Family
ID=57281299
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
KR1020187014634A KR20180084817A (en) | 2015-10-29 | 2016-10-28 | Anti-SIGLEC-9 antibodies and methods of using the same |
Country Status (10)
Country | Link |
---|---|
US (3) | US10800844B2 (en) |
EP (1) | EP3368575A2 (en) |
JP (2) | JP7060502B2 (en) |
KR (1) | KR20180084817A (en) |
CN (2) | CN116003596A (en) |
AU (1) | AU2016343987B2 (en) |
CA (1) | CA3003458A1 (en) |
HK (1) | HK1252698A1 (en) |
SG (1) | SG11201803567XA (en) |
WO (1) | WO2017075432A2 (en) |
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KR101997241B1 (en) | 2015-05-21 | 2019-07-09 | 하푼 테라퓨틱스, 인크. | Trispecific binding proteins and methods of use |
WO2017075432A2 (en) * | 2015-10-29 | 2017-05-04 | Alector Llc | Anti-siglec-9 antibodies and methods of use thereof |
WO2017123745A1 (en) * | 2016-01-12 | 2017-07-20 | Palleon Pharma Inc. | Use of siglec-7 or siglec-9 antibodies for the treatment of cancer |
US11623958B2 (en) | 2016-05-20 | 2023-04-11 | Harpoon Therapeutics, Inc. | Single chain variable fragment CD3 binding proteins |
KR20190118172A (en) | 2017-02-08 | 2019-10-17 | 드래곤플라이 쎄라퓨틱스, 인크. | Multispecific Binding Proteins for Activation of Natural Killer Cells and Their Therapeutic Uses in Cancer Treatment |
JP2020508997A (en) | 2017-02-20 | 2020-03-26 | ドラゴンフライ セラピューティクス, インコーポレイテッド | Proteins that bind to Her2, NKG2D and CD16 |
JOP20190248A1 (en) | 2017-04-21 | 2019-10-20 | Amgen Inc | Trem2 antigen binding proteins and uses thereof |
CN113896792A (en) | 2017-05-12 | 2022-01-07 | 哈普恩治疗公司 | Mesothelin binding proteins |
WO2019011855A1 (en) * | 2017-07-10 | 2019-01-17 | Innate Pharma | Siglec-9-neutralizing antibodies |
CR20200195A (en) | 2017-10-13 | 2020-08-14 | Harpoon Therapeutics Inc | B cell maturation antigen binding proteins |
CN112368012B (en) | 2018-02-08 | 2024-09-10 | 蜻蜓疗法股份有限公司 | Antibody variable domains targeting the NKG2D receptor |
US20210221894A1 (en) * | 2018-04-03 | 2021-07-22 | Dragonfly Therapeutics, Inc. | Proteins binding nkg2d, cd16 and an antigen associated with tumors, mdscs and/or tams |
US20220025037A1 (en) * | 2018-04-03 | 2022-01-27 | Dragonfly Therapeutics, Inc. | Antibody variable domains targeting dll3, and use thereof |
JP7562421B2 (en) * | 2018-06-07 | 2024-10-07 | パレオン ファーマシューティカルズ インコーポレイテッド | Multimeric proteins for detecting carbohydrates and/or treating siglec-mediated disorders - Patents.com |
JP2022501319A (en) * | 2018-09-25 | 2022-01-06 | アカデミア シニカAcademia Sinica | Anti-Siglec antibody, pharmaceutical composition comprising it and its use |
KR20210086623A (en) | 2018-09-25 | 2021-07-08 | 하푼 테라퓨틱스, 인크. | DDL3 Binding Proteins and Methods of Use |
US20210251199A1 (en) * | 2018-12-14 | 2021-08-19 | Central Institute For Experimental Animals | Non-human vertebrate comprising human liver cells transplanted therein and method for producing the same |
CA3142433A1 (en) * | 2019-06-04 | 2020-12-10 | Verseau Therapeutics, Inc. | Anti-siglec-9 compositions and methods for modulating myeloid cell inflammatory phenotypes and uses thereof |
WO2021024020A1 (en) | 2019-08-06 | 2021-02-11 | Astellas Pharma Inc. | Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer |
CN114667298A (en) | 2019-11-04 | 2022-06-24 | 艾利妥 | SIGLEC-9ECD fusion molecules and methods of use thereof |
CN114787189A (en) | 2019-11-14 | 2022-07-22 | 备忘录疗法股份公司 | anti-Siglec-9 antibody molecules |
CN113138273B (en) * | 2020-01-17 | 2024-06-18 | 孟民杰 | Kit applied to rapid screening and immune targeting therapy detection of lung cancer and application thereof |
CA3187996A1 (en) * | 2020-06-30 | 2022-01-06 | The Board Of Trustees Of The Leland Stanford Junior University | Cis-binding siglec agonists and related compositions and methods |
EP4178611A1 (en) | 2020-07-07 | 2023-05-17 | BioNTech SE | Therapeutic rna for hpv-positive cancer |
WO2022135667A1 (en) | 2020-12-21 | 2022-06-30 | BioNTech SE | Therapeutic rna for treating cancer |
TW202245808A (en) | 2020-12-21 | 2022-12-01 | 德商拜恩迪克公司 | Therapeutic rna for treating cancer |
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2016
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- 2016-10-28 CN CN202210928869.7A patent/CN116003596A/en active Pending
- 2016-10-28 CN CN201680076417.3A patent/CN108431041B/en active Active
- 2016-10-28 US US15/772,010 patent/US10800844B2/en active Active
- 2016-10-28 EP EP16794481.8A patent/EP3368575A2/en active Pending
- 2016-10-28 AU AU2016343987A patent/AU2016343987B2/en active Active
- 2016-10-28 CA CA3003458A patent/CA3003458A1/en active Pending
- 2016-10-28 KR KR1020187014634A patent/KR20180084817A/en not_active Application Discontinuation
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US11667710B2 (en) | 2023-06-06 |
JP2022046479A (en) | 2022-03-23 |
WO2017075432A2 (en) | 2017-05-04 |
CN116003596A (en) | 2023-04-25 |
US20210095023A1 (en) | 2021-04-01 |
US20240067723A1 (en) | 2024-02-29 |
WO2017075432A3 (en) | 2017-06-15 |
US10800844B2 (en) | 2020-10-13 |
AU2016343987B2 (en) | 2023-11-23 |
AU2016343987A1 (en) | 2018-05-24 |
JP2019500014A (en) | 2019-01-10 |
CN108431041B (en) | 2022-08-16 |
HK1252698A1 (en) | 2019-05-31 |
US20190062427A1 (en) | 2019-02-28 |
SG11201803567XA (en) | 2018-05-30 |
JP7060502B2 (en) | 2022-04-26 |
EP3368575A2 (en) | 2018-09-05 |
CA3003458A1 (en) | 2017-05-04 |
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