KR20180072019A - Method of measuring topographic changes of the macula and program of thereof - Google Patents

Abstract

The present invention relates to a method of measuring a moving trajectory of an ocular retina region, provided to conveniently and accurately measure blood vessel displacement of a macular part in a macular disease. In a program for measuring the blood vessel displacement in a macular disease, the method of measuring a moving trajectory of an ocular retina region includes: a first step of registering optical coherence tomography (OCT) photographed together with a fundus picture and provided to arbitrarily select a blood vessel by a user to create an index mark; a second step of creating a reference value for measuring a moving distance in the fundus picture by matching the registered OCT and the fundus picture before treating the macular disease; a third step of changing two fundus pictures photographed at different time points before and after treatment into an RGB green channel; a fourth step of removing portions with no information on blood vessels from the two fundus pictures changed to the RGB green channel; a fifth step of automatically overlapping the two pictures by setting and matching blood vessel feature points as index marks in the fundus pictures, in which the portions with no information on vessels are removed; a sixth step of activating a coordinate system for measuring a blood vessel displacement vector in the overlapped fundus pictures; and a seventh step of measuring a moving distance of the blood vessel by comparing the two pictures in each sector of the activated coordinate system. The present invention may conveniently and accurately measure blood vessel displacement of a fundus between two time points and display a movement state of a macula organ on a map.

Description

FIELD OF THE INVENTION [0001] The present invention relates to a method for measuring an eyeball movement trajectory,

The present invention relates to a method for measuring an ocular retinal area movement trajectory provided to easily and accurately measure a blood vessel displacement of the macular part in macular diseases.

The major part of the retina is formed as a layered structure, especially when the structures of the macula, which is the center of the innermost retina, are structurally deformed, they develop into vision loss or severe vision loss. According to the National Health Insurance Corporation, the number of patients with age-related macular degeneration (PVD) is nearly doubling from 7,631 in 2000 to 13,673 in 2004. Macular degeneration associated diseases are the main cause of blindness, including age-related macular degeneration, macular hole, and retina. Especially, these diseases are the most common in retinal surgery.

In most patients after surgery due to the macular hole or retina, the postoperative visual acuity is somewhat recovered, but many patients suffer from persistent optic atrophy. Visualization of an object is not directly related to visual acuity, but it is an important factor in the quality of vision. However, there are various explanations about the mechanism of the occurrence of varicosis, but it is not yet fully understood. The most important explanation is that the preoperative macular degeneration occurs in the retina of the macula, which in turn affects retinal internal nerve conduction and /

Although it is thought that the positional shift of the macular tissue is important for the visual acuity in macular diseases, there has not been developed a technique for quantifying and analyzing the macular location. In order to identify the cause of varicose vein and to treat it, a technique that can accurately measure the positional shift of macular tissue will be needed.

Korean Patent No. 10-1118146

SUMMARY OF THE INVENTION The present invention has been made in order to solve the above problems, and it is an object of the present invention to easily and accurately measure vessel displacement of fundus for macular hole treatment or surgery.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are not restrictive of the invention as set forth in the accompanying drawings. It will be possible.

A method for measuring an ocular retinal area movement trajectory according to the present invention is a program for measuring a vessel displacement in two funduscopic photographs taken at different points of time, the optical coherence tomography, OCT), and generating a marking point by allowing a user to arbitrarily select a blood vessel; A second step of matching a fundus photograph taken together with the registered OCT to generate a reference value capable of measuring an actual size in a fundus photograph; A third step of changing the two fundus photographs photographed at the two viewpoints to an RGB green channel; A fourth step of removing information-free portions of blood vessels from two fundus photographs changed to the RGB green channel; A fifth step of superimposing fundus photographs on a fundus photograph from which a portion of the blood vessel without information is removed by matching the marking points of blood vessels; A sixth step of activating a coordinate system for measuring a blood vessel displacement in the overlapping fundus photograph; And a seventh step of measuring a distance traveled by the blood vessel using the activated coordinate system.

According to the solution of the above-mentioned problems, the present invention can easily and accurately measure the angular displacement of the fundus between the two periods in macular diseases and can display the moving state of the macular tissues with a map.

FIG. 1 is a view showing a step of a method for measuring an eyeball retinal movement locus according to the present invention.
FIG. 2 is a photograph showing a step of registering optical coherence tomography (OCT) taken with a fundus photograph before macular hole surgery in a first step (S10).
FIG. 3 is a photograph of a blood vessel marking point on the fundus photograph before the macular hole surgery in the second step (S20) of the present invention and matching with the registered optical coherence tomography.
FIG. 4 is a photograph of the fundus photograph before and after the macular hole surgery in the third step (S30) of the present invention is changed to an RGB green channel.
FIG. 5 is a photograph showing a step of removing information-free portions of the blood vessels from the fundus photographs before and after the macular hole surgery changed from the fourth step S40 of the present invention to the RGB green channel.
FIG. 6 is a photograph in which the blood vessels become clear after removing the information-free portion of the blood vessel in the fourth step S40 of the present invention.
FIG. 7 is a photograph in which a blood vessel marking point is set in a fundus photograph in which a part without information of the blood vessel is removed in a fifth step (S50) of the present invention.
FIG. 8 is a photograph in which the photographs of macula hole surgery before and after macular hole surgery are superimposed by matching the blood vessel marking points in the fifth step (S50) of the present invention.
FIG. 9 is a photograph showing a coordinate system of an fundus photograph for activating a blood vessel displacement vector in the overlapped photograph in a sixth step S60 of the present invention. FIG.
FIG. 10 is a photograph of a distance measured by moving a blood vessel by comparing images before and after surgery in each sector of the activated coordinate system in a seventh step (S70) of the present invention.

The above and other objects, features and advantages of the present invention will be more apparent from the following detailed description taken in conjunction with the accompanying drawings, in which: FIG. BRIEF DESCRIPTION OF THE DRAWINGS The advantages and features of the present invention and the manner of achieving them will become apparent by reference to an embodiment which will be described in detail below with reference to the accompanying drawings.

First, in step S10, an optical coherence tomography (OCT) photographed with an eye fundus photograph before the macular hole treatment is registered, and a blood vessel is selected by a user to generate a marking point. Since fundus photography does not have a means to measure the length, registering OCT is to generate a reference for measuring the exact length of the blood vessel.

In general, optical coherence tomography (OCT) is designed to photograph a region in a 6 mm x 6 mm region, but in the case of a facial optical tomography (OCT) designed to capture a different region, It is preferable to input the size of the image.

In addition, in the first step (S10), the user is allowed to arbitrarily select vascular feature points to generate the marking points. The user takes two of the most characteristic blood vessels. It is preferable that when the two mark points are selected, each point is divided into different colors. Specifically, when the above-mentioned point is displayed in red color, the other point is preferably displayed in blue color.

Next, the second step S20 matches the registered optical coherence tomography (OCT) with the fundus photograph before the macular hole treatment.

Specifically, the matching step of the second step (S20) is to match by selecting a blood vessel part such as the registered mark point in the first step (S10).

Also, as shown in FIG. 3, it is preferable that the magnifying glass is provided in the matching step S20 so that it can be precisely selected.

Next, in the third step S30, two fundus photographs before and after the macular hole surgery are changed to the RGB green channel.

Specifically, in order to more accurately confirm the blood vessels in the fundus photographs before and after the treatment of the macular hole, the image is changed to an RGB (green) channel as shown in FIG. In comparison with FIG. 3, it can be seen that the fundus photograph can be confirmed more accurately in FIG.

Next, the fourth step S40 removes the information portion of the blood vessel from the fundus photograph before and after the treatment of the macular hole changed to the RGB green channel.

As shown in FIG. 5, it is preferable that the fundus photograph is plotted with a histogram curve and then a portion without information is cut out. In the case of FIG. 6 in which the fourth step S40 has been performed, it can be seen that the blood vessels of the fundus photograph are more clearly shown in comparison with FIG.

Next, in a fifth step S50, a marking point of the same blood vessel region is set in a fundus photograph in which a portion having no information of the blood vessel is removed.

As shown in FIG. 7, it is preferable to compare the pictures after the macular hole treatment in the photographs before the macular hole treatment to set the blood vessel branch sites having distinct features as the marking points.

As shown in FIG. 8, the markers are accurately overlapped with each other by matching mark points before the macular hole treatment and after the macular hole treatment, and the present invention can be applied to auto-align So that the magnification, the position and the angle of the two pictures can be automatically adjusted and overlapped with each other.

Next, in a sixth step S60, the coordinate system of the fundus photograph for measuring the blood vessel displacement vector is activated in the overlapping fundus photograph.

As shown in FIG. 9, in the sixth step S60, a coordinate system including 16 sectors is superposed on a photograph, and it is possible to measure the blood vessel movement in each sector. Further, the coordinate system is activated by being displayed at 2 mm, 4 mm, 6 mm and 8 mm from the center.

Next, in a seventh step (S70), the distance traveled by the blood vessel is measured by comparing two photographs in each sector of the activated coordinate system. In the seventh step S70, it is preferable to measure the distance traveled by the blood vessels in all the sectors and visualize the distance.

As shown in FIG. 10, if a portion marked in red is identified, the direction of movement of the blood vessel can be confirmed through a black arrow, and the moving distance of the blood vessel indicated by L and the moving angle of the blood vessel indicated by A It is preferable that it is provided so that it can be confirmed. More specifically, as shown in Fig. 10, it can be seen that the blood vessels were moved in the arrow direction by a distance of 102.6 mu m and 128.0 mu m, respectively.

Hereinafter, a case of using the method of measuring the movement trajectory of the retina of the eye of the present invention when the vitrectomy is performed will be described by way of examples.

Macular Hole Idiopathic (Macular Hole) Idiopathic macular hole surgery was performed in 6 centers (Pusan National University Hospital, Pusan National University Hospital, Busan Paik Hospital, Haeundae Paik Hospital, Kosin University Hospital, Gyeongsang National University Hospital) between 2012 and 2014 The study was conducted on 73 patients (24 males, 49 females). The mean age was 64.9 ± 6.5 years (range: 50-79 years). Lens status was 66 eyes, and 7 eyes were IOLs. The average corrected visual acuity was 0.93 ± 0.39 logMAR (Median Snellen visual acuity: 20/125) and improved to 0.44 ± 0.32 logMAR (Median Snellen visual acuity: 20/40) after surgery. The mean macular hole diameter was 458.4 ± 185.9 mm horizontal and 434.4 ± 194.1 mm vertically. The mean macular hole diameter was 825.4 ± 288.4 mm horizontally and 760.3 ± 266.9 mm vertically.

The displacement data are expressed as the distance and angle between the average displacement vector of each sector and each ring. The Mann-Whitney U test was used to analyze differences in inter-sectoral movements. Correlation between clinical variables and blood vessel potential was determined by the Spearman correlation coefficient. Multilinear regression analysis using stepwise variable selection was used to identify temporal factors of mean displacement of the blood vessels in the internal and external blood vessel sectors and the entire macula. All statistical analyzes were performed using the Social Science Statistical Package for Windows 21.0 (SPSS Inc, Chicago, IL). Statistical significance was accepted at P <0.05.

The average displacement distance and angle for each sector are shown in Table 1 below.

Sector T IT I IN N SN S ST Inner ring
Distance (탆) 121.3 108.2 73.4 63.9 43.6 68.2 93.0 125.4 Angle (°) -5.3 12.5 26.1 44.8 3.8 -39.5 -34.6 -12.9 No. eyes 54 69 65 62 36 57 65 65 Outer ring
Distance (탆) 52.0 39.4 34.0 29.3 26.9 36.6 40.6 51.1 Angle (°) -4.1 0.5 35.2 44.7 8.5 -34.5 -36.4 -5.4 No. eyes 67 67 66 59 55 61 61 70

(T, temporal, IT, inferno -temporal; I, inferior; IN, inferno -nasal; N, nasal; SN, supero-nasal; S, superior; ST, supero-temporal)

As shown in Table 1, the mean displacement was 23.3 ° at 57.2 mm in each macular, 22.9 ° and 79.2 mm in the inner vessel, and 24.4 ° and 35.3 mm in the outer vessel, respectively. The displacement was statistically greater in the inner vessel than in the outer vessel (P, <0.001). The mean displacement was the largest at 125.4 mm in the ST (supero-temporal) segment of the internal vascular sector and the smallest at 26.9 mm in the non-segment of the external vascular sector.

According to the solution of the above-mentioned problems, it can be understood that the present invention can easily and accurately measure the blood vessel displacement of the fundus in a disease.

As described above, it is to be understood that the technical structure of the present invention can be embodied in other specific forms without departing from the spirit and essential characteristics of the present invention.

Therefore, it should be understood that the above-described embodiments are to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than the foregoing description, All changes or modifications that come within the scope of the equivalent concept are to be construed as being included within the scope of the present invention.

S10. A first step of registering a photograph by optical coherence tomography (OCT) of the eye fundus after the macular hole treatment and generating a mark point by being provided for the user to arbitrarily select the feature point of the blood vessel,
S20. A second step of matching the registered optical coherence tomography with the fundus photograph before the macular hole treatment to generate a reference value for measurement of the blood vessel displacement
S30. The third step is to change the two fundus photographs before and after the macular hole treatment to the known (RGB) green channel
S40. The fourth step of removing the information-free part of the blood vessels from the fundus photograph before and after the treatment of the macular hole changed to the RGB (green) channel
S50. A fifth step of overlapping two fundus photographs by setting a marking point of a blood vessel displacement in a fundus photograph in which a part without information of the blood vessel is removed,
S60. A sixth step of activating a coordinate system for measuring a blood vessel displacement vector in the overlapping fundus photograph,
S70. A seventh step of measuring a distance of movement of the blood vessel in each sector of the activated coordinate system

Claims (5)

In a program for measuring vessel displacement in a macular disease,
A first step of registering optical coherence tomography (OCT) images taken with fundus photographs in the macular diseases, and generating a marking point by a user to arbitrarily select a blood vessel;
And comparing the registered optical coherence tomography with the pre-treatment fundus photograph, wherein a blood vessel identical to the blood vessel characteristic point selected in the first step is selected from the pre-treatment fundus photograph, A second step of generating a second step;
A third step of changing two fundus photographs taken at two points in the macular disease before and after treatment into an RGB green channel;
A fourth step of removing information-free portions of the blood vessels from the two fundus photographs before and after the therapy changed to the RGB green channel;
A fifth step of automatically matching two pictures by setting and matching vascular feature points to a mark point in a fundus photograph in which a part having no information of the blood vessel is removed;
A sixth step of activating a coordinate system for measuring a blood vessel displacement vector in the overlapping fundus photograph;
And a seventh step of measuring a distance traveled by the blood vessel in each sector of the activated coordinate system. The method according to claim 1,
The first step of registering the optical coherence tomography (OCT)
And a reference value capable of measuring the actual length in the fundus photograph by inputting the size of the photographed region, The method according to claim 1,
The first step of registering the optical coherence tomography (OCT)
Wherein the blood vessel selected by the user is divided into different colors, The method according to claim 1,
A method for measuring the movement trajectory of an eye retina with a magnifying glass for selecting vascular feature points in two fundus photographs taken at different times 5. The method according to any one of claims 1 to 4,
The program using the above-mentioned retinal area locus measurement method

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