KR20180069527A - Cosmetic Composition for skin moisturizing comprising Panax notoginsengs extracts - Google Patents
Cosmetic Composition for skin moisturizing comprising Panax notoginsengs extracts Download PDFInfo
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- KR20180069527A KR20180069527A KR1020160171794A KR20160171794A KR20180069527A KR 20180069527 A KR20180069527 A KR 20180069527A KR 1020160171794 A KR1020160171794 A KR 1020160171794A KR 20160171794 A KR20160171794 A KR 20160171794A KR 20180069527 A KR20180069527 A KR 20180069527A
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- extract
- present
- composition
- skin
- moisturizing
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
- A23V2200/318—Foods, ingredients or supplements having a functional effect on health having an effect on skin health and hair or coat
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/333—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using mixed solvents, e.g. 70% EtOH
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Botany (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Birds (AREA)
- Alternative & Traditional Medicine (AREA)
- Medical Informatics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Nutrition Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Dermatology (AREA)
- Cosmetics (AREA)
Abstract
Description
본 발명은 삼칠 추출물을 포함하는 피부 보습용 화장료 조성물, 식품 조성물 및 의약외품 조성물에 관한 것이다.The present invention relates to a cosmetic composition for skin moisturizing, a food composition, and a quasi-drug composition comprising an extract of Trichomoniasis.
일반적으로 피부에 사용되는 보습용 화장료 조성물은 사람의 모발이나 피부 등에 수분을 일정량 유지함으로써 부드럽고 생기있게 보이게 하며, 갈라짐, 건조함 등의 손상을 방지해주는 기능을 한다. 즉, 피부 보습용 화장료 조성물은 피부나 모발에 일정량 이상의 수분을 공급하거나 수분이 유지되게 함으로써 피부나 모발을 미화하고, 건강하게 유지하게 하기 위한 목적으로 사용된다. Generally, the moisturizing cosmetic composition used for the skin has a function of preventing damages such as cracking and drying by making the skin look soft and vivid by keeping a certain amount of water on human hair or skin. That is, the cosmetic composition for moisturizing the skin is used for the purpose of supplying more than a certain amount of water to the skin or hair or keeping the moisture to beautify the skin or hair and keep it healthy.
피부가 수분 조절에 약 65-70%를 담당하므로 화장품 분야에서는 수분의 공급, 유지, 즉 보습에 대한 연구가 활발하며, 최근에는 천연물 등으로부터 얻은 생리 활성 물질을 화장료에 도입하여 피부 자체의 고유 방어 기능을 유지시킴으로써 보습력을 증가시키는 화장품의 개발이 활발해지고 있다.Since the skin is responsible for about 65-70% of the moisture control, studies on the supply, maintenance, and moisturization of water have been actively conducted in the field of cosmetics. Recently, a physiologically active substance obtained from natural products has been introduced into cosmetics, The development of cosmetics that increase the moisturizing power by keeping the function is becoming active.
예를 들어, 대한민국 공개특허 제2002-0044266호에서는 복합생약 추출물을 포함하는 피부 보호용 화장료 조성물을 개시하고 있다. 다만, 생약 추출물 단독, 자체의 피부 보호 효과에 대해서는 개시하지 않았다.For example, Korean Patent Publication No. 2002-0044266 discloses a cosmetic composition for skin protection comprising a complex herbal extract. However, the herbal extract alone and its skin protection effect were not disclosed.
한편, 삼칠(三七) Panax notoginseng F. H. Chen (두릅나무과 Araliaceae)의 뿌리 및 뿌리 줄기이다. 삼칠은 다년생 초본으로 가을에 채취하여 뿌리를 약재로 사용하며, 절상으로 생긴 출혈과 내출혈에 유효한 것으로 알려져 있다. 삼칠 이외에 혈삼, 전칠, 전삼칠, 인삼삼칠로 명명될 수 있다. On the other hand, thirty-seven (三七) Panax It is the root and rootstock of notoginseng FH Chen (Araliaceae and Araliaceae). It is a perennial herb that is picked in autumn and used as a medicinal herb. It is known to be effective for hemorrhage and internal bleeding caused by raising. In addition to Samcheon, it can be named blood ginseng, panchil, japanese ginseng, ginseng and three days.
이러한 배경하에, 본 발명자들은 피부 보습 효과가 우수한 물질에 관하여 연구를 수행하였으며, 본초 추출물 중 특히 삼칠 추출물을 유효 성분으로 포함하는 조성물이 우수한 보습 효과를 나타냄을 규명하여, 이를 활용한 화장료 조성물, 식품 조성물 및 의약외품 조성물을 완성하기에 이르렀다. Under these circumstances, the inventors of the present invention conducted studies on a substance having excellent skin moisturizing effect, and found out that a composition containing an extract of Trichomoniasis as an effective ingredient in the extract of the herb extract showed excellent moisturizing effect, Thereby completing the composition and the quasi-drug composition.
본 발명의 목적은 삼칠 추출물 또는 이의 분획물을 유효성분으로 포함하는 피부 보습용 화장료 조성물을 제공하는 것이다.It is an object of the present invention to provide a cosmetic composition for moisturizing the skin comprising the extract or the fraction thereof as an active ingredient.
본 발명의 다른 목적은 삼칠 추출물 또는 이의 분획물을 유효성분으로 포함하는 피부 보습용 식품 조성물을 제공하는 것이다.It is another object of the present invention to provide a food composition for skin moisturizing which comprises an extract or a fraction thereof as an active ingredient.
본 발명의 또 다른 목적은 삼칠 추출물 또는 이의 분획물을 유효성분으로 포함하는 피부 보습용 의약외품 조성물을 제공하는 것이다.It is still another object of the present invention to provide a quasi-drug composition for skin moisturizing, which contains an extract or a fraction thereof as an active ingredient.
본 발명은 상기와 같은 과제들을 해결하고, 본 발명의 목적을 달성하기 위하여 삼칠 추출물 또는 이의 분획물을 포함하는 피부 보습용 화장료 조성물을 제공한다.The present invention provides cosmetic compositions for moisturizing the skin, comprising the extract or the fractions thereof, in order to solve the above-mentioned problems and to achieve the object of the present invention.
본 발명의 또 다른 양태로서 삼칠 추출물 또는 이의 분획물을 유효성분으로 포함하는 피부 보습용 식품 조성물을 제공한다.As another embodiment of the present invention, there is provided a food composition for skin moisturizing comprising an extract or a fraction thereof as an active ingredient.
본 발명의 또 다른 양태로서 삼칠 추출물 또는 이의 분획물을 유효성분으로 포함하는 피부 보습용 의약외품 조성물을 제공한다.In another embodiment of the present invention, there is provided a quasi-drug composition for skin moisturizing comprising an extract or a fraction thereof as an active ingredient.
이하, 본 발명을 자세히 설명한다.Hereinafter, the present invention will be described in detail.
본 발명에서는 삼칠 추출물 또는 이의 분획물을 포함하는 피부 보습용 조성물을 제공한다.The present invention provides a composition for moisturizing skin comprising the extract or a fraction thereof.
본 발명에 있어서, 삼칠(三七) Panax notoginseng F. H. Chen (두릅나무과 Araliaceae)의 뿌리 및 뿌리 줄기이다. 삼칠은 다년생 초본으로 가을에 채취하여 뿌리를 약재로 사용하며, 절상으로 생긴 출혈과 내출혈에 유효한 것으로 알려져 있다. 삼칠 이외에 혈삼, 전칠, 전삼칠, 인삼삼칠로 명명될 수 있다. In the present invention, thirty-seven (三七) Panax It is the root and rootstock of notoginseng FH Chen (Araliaceae and Araliaceae). It is a perennial herb that is picked in autumn and used as a medicinal herb. It is known to be effective for hemorrhage and internal bleeding caused by raising. In addition to Samcheon, it can be named blood ginseng, panchil, japanese ginseng, ginseng and three days.
본 발명에서 사용되는 용어, "추출물"은 상기 삼칠의 추출처리에 의하여 얻어지는 추출액, 상기 추출액의 희석액이나 농축액, 상기 추출액을 건조하여 얻어지는 건조물, 상기 추출액의 조정제물이나 정제물, 또는 이들의 혼합물 등, 추출액 자체 및 추출액을 이용하여 형성 가능한 모든 제형의 추출물을 포함한다.The term "extract" used in the present invention refers to an extract obtained by the above three-third extraction treatment, a diluted solution or concentrate of the extract, a dried product obtained by drying the extract, a preparation or a purified product of the extract, , The extract itself and extracts of all the formulations that can be formed using the extract.
본 발명의 상기 추출물은, 상기 각각의 해당 식물의 천연, 잡종 또는 변종 식물로부터 추출될 수 있고, 식물 조직 배양물로부터도 추출이 가능하다.The extract of the present invention can be extracted from natural, hybrid, or mutant plants of the respective plants, and can also be extracted from plant tissue cultures.
본 발명의 상기 삼칠의 추출에 있어서, 상기 추출물을 추출하는 방법은 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 추출할 수 있다. 상기 추출 방법의 비제한적인 예로는, 열수 추출법, 초음파 추출법, 여과법, 환류 추출법 등을 들 수 있으며, 이들은 단독으로 수행되거나 2 종 이상의 방법을 병용하여 수행될 수 있다.In the above three-third extraction of the present invention, the method for extracting the extract is not particularly limited, and extraction can be carried out according to a method commonly used in the art. Non-limiting examples of the extraction method include hydrothermal extraction, ultrasonic extraction, filtration, and reflux extraction. These may be performed alone or in combination with two or more methods.
본 발명에서 상기 삼칠을 추출하는데 사용되는 추출용매의 종류는 특별히 제한되지 아니하며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 추출 용매의 비제한적인 예로는 물; 메탄올, 에탄올, 프로필알코올, 부틸알코올 등의 C1 내지 C4의 저급 알코올; 글리세린, 부틸렌글리콜, 프로필렌글리콜 등의 다가 알코올; 및 메틸아세테이트, 에틸아세테이트, 아세톤, 벤젠, 헥산, 디에틸에테르, 디클로로메탄 등의 탄화수소계 용매; 또는 이들의 혼합물을 사용할 수 있으며, 바람직하게, 물, 저급알코올, 1,3-부틸렌글리콜, 에틸아세테이트를 단독으로 사용하거나 2종 이상 혼합하여 사용할 수 있다. In the present invention, the kind of the extraction solvent used for extracting the three-twill is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the extraction solvent include water; C1 to C4 lower alcohols such as methanol, ethanol, propyl alcohol and butyl alcohol; Polyhydric alcohols such as glycerin, butylene glycol and propylene glycol; And hydrocarbon solvents such as methyl acetate, ethyl acetate, acetone, benzene, hexane, diethyl ether, and dichloromethane; Or a mixture thereof. Water, lower alcohol, 1,3-butylene glycol, and ethyl acetate may be used alone or in admixture of two or more.
본 발명에서 삼칠의 한약재를 추출하는 용매로 보다 바람직하게는 물(또는 증류수)을 사용할 수 있다. 상기 용매를 사용하여 삼칠의 한약재를 1회 이상 추출하여 용매 추출물을 제조할 수 있으며, 상기 용매 추출물을 감압 증류한 후 동결건조 또는 분무 건조하여 얻은 건조 추출물을 제조할 수 있다. 본 발명의 구체적인 일 실시예에서는 물(또는 증류수)를 사용하여 삼칠의 추출물을 제조하였다.In the present invention, water (or distilled water) may be used as a solvent for extracting the herb medicine of the present invention. A solvent extract may be prepared by extracting the herbal medicines one or more times by using the solvent, and the dry extract obtained by vacuum distillation or spray drying the solvent extract may be prepared. In one specific embodiment of the present invention, water (or distilled water) was used to prepare a three-day extract.
본 발명에서 열수 추출 또는 냉침 추출한 추출물은 부유하는 고체 입자를 제거하기 위해 여과, 예를 들어 나일론 등을 이용해 입자를 걸러내거나 냉동여과법 등을 이용해 여과한 후, 그대로 사용하거나 이를 동결건조, 열풍건조, 분무건조 등을 이용해 건조시켜 사용할 수 있다.In the present invention, the extract obtained by hot water extraction or cold extraction is filtered to remove suspended solid particles by filtration, for example, nylon or the like, or by freeze filtration, Spray drying and the like.
본 발명에서 사용되는 용어, "분획물"은 여러 다양한 구성 성분들을 포함하는 혼합물로부터 특정 성분 또는 특정 성분 그룹을 분리하기 위하여 분획을 수행하여 얻어진 결과물을 의미한다.The term "fraction " as used herein means a product obtained by performing fractionation to separate a specific component or a specific component group from a mixture containing various components.
본 발명에서 상기 분획물을 얻는 분획 방법은 특별히 제한되지 아니하며, 당해 기술 분야에서 통상적으로 사용하는 방법에 따라 수행될 수 있다. 상기 분획 방법의 비제한적인 예로는, 삼칠을 추출하여 얻은 추출물에 소정의 용매를 처리하여 상기 추출물로부터 분획물을 얻는 방법을 들 수 있다.The fractionation method for obtaining the fraction in the present invention is not particularly limited and may be carried out according to a method commonly used in the art. As a non-limiting example of the above-mentioned fractionation method, there can be mentioned a method in which a fraction obtained from the extract is obtained by treating a predetermined solvent with an extract obtained by extracting three-thirds.
본 발명에서 상기 분획물을 얻는 데에 사용되는 용매의 종류는 특별히 제한되지 아니하며, 당해 기술 분야에서 공지된 임의의 용매를 사용할 수 있다. 상기 분획 용매의 비제한적인 예로는 물, 알코올 등의 극성 용매; 헥산 (Hexane), 에틸아세테이트 (Ethyl acetate), 클로로포름 (Chloroform), 디클로로메탄(Dichloromethane) 등의 비극성 용매 등을 들 수 있다. 이들은 단독으로 사용되거나 2 종 이상 혼합하여 사용될 수 있다. 상기 분획 용매 중 알코올을 사용하는 경우에는 구체적으로는 C1 내지 C4의 알코올을 사용할 수 있다.The kind of the solvent used for obtaining the fraction in the present invention is not particularly limited, and any solvent known in the art can be used. Non-limiting examples of the fraction solvent include polar solvents such as water and alcohol; And non-polar solvents such as hexane, ethyl acetate, chloroform, and dichloromethane. These may be used alone or in combination of two or more. When an alcohol is used in the fraction solvent, specifically C1 to C4 alcohols can be used.
본 발명은 삼칠 추출물 또는 이의 분획물을 포함하는 피부 보습용 화장료 조성물을 제공한다. The present invention provides a cosmetic composition for moisturizing the skin comprising the extract or the fraction thereof.
본 발명에 있어서, “피부 보습”이란 피부에 수분감을 증가시켜주고, 촉촉한 상태를 유지시키는 것을 의미한다. 피부 보습 효과는 피부의 주름개선, 탄력도 증가에 도움을 줄 수 있다. 본 발명의 삼칠 추출물의 우수한 수분 보유능 효과를 나타내었는바, 이로부터 본 발명의 삼칠 추출물을 포함하는 조성물은 피부 보습 용도로 사용될 수 있음을 확인하였다(표 2).In the present invention, " skin moisturizing " means increasing moisture in the skin and maintaining a moist state. Skin moisturizing effect can help to improve wrinkles and elasticity of skin. The water extracting ability of the extract of the present invention was shown to be excellent, and it was confirmed that the composition containing the extract of the present invention can be used for skin moisturizing (Table 2).
본 발명에 따른 화장료 조성물은 용액, 외용연고, 크림, 폼, 영양화장수, 유연화장수, 팩, 유연수, 유액, 메이크업베이스, 에센스, 비누, 액체 세정료, 입욕제, 선 스크린크림, 선오일, 현탁액, 유탁액, 페이스트, 겔, 로션, 파우더, 비누, 계면활성제-함유 클린싱, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 패취 및 스프레이로 구성된 군으로부터 선택되는 제형으로 제조할 수 있으나, 이에 제한되는 것은 아니다.The cosmetic composition according to the present invention can be used as a cosmetic composition in the form of a solution, an ointment for external use, a cream, a foam, a nutritional lotion, a softening water, a pack, a soft water, an emulsion, a makeup base, But are not limited to, emulsions, emulsions, pastes, gels, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations, patches and sprays It is not.
또한, 본 발명의 화장료 조성물은 일반 피부 화장료에 배합되는 화장품학적으로 허용 가능한 담체를 1 종 이상 추가로 포함할 수 있으며, 통상의 성분으로 예를 들면 유분, 물, 계면활성제, 보습제, 저급 알콜, 증점제, 킬레이트제, 색소, 방부제, 향료 등을 적절히 배합할 수 있으나, 이에 제한되는 것은 아니다.In addition, the cosmetic composition of the present invention may further comprise at least one cosmetically acceptable carrier to be incorporated in a general skin cosmetic composition, and examples thereof include oil, water, a surfactant, a moisturizer, A thickening agent, a chelating agent, a coloring matter, an antiseptic, a perfume, and the like may be appropriately compounded, but the present invention is not limited thereto.
본 발명의 화장료 조성물에 포함되는 화장품학적으로 허용 가능한 담체는 제형에 따라 다양하다.The cosmetically acceptable carrier to be contained in the cosmetic composition of the present invention varies depending on the formulation.
본 발명의 제형이 연고, 페이스트, 크림 또는 젤인 경우에는, 담체 성분으로서 동물성 유, 식물성 유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크, 산화아연 또는 이들의 혼합물이 이용될 수 있다.When the formulation of the present invention is an ointment, a paste, a cream or a gel, the carrier component may be an animal oil, a vegetable oil, a wax, a paraffin, a starch, a tracer, a cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc, zinc oxide Mixtures of these may be used.
본 발명의 제형이 파우더 또는 스프레이인 경우에는, 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록사이드, 칼슘 실케이트, 폴리아미드 파우더 또는 이들의 혼합물이 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진제를 포함할 수 있다.When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate, polyamide powder or a mixture thereof may be used as the carrier component, Propellants such as fluorohydrocarbons, propane / butane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액인 경우에는, 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되며, 예컨대 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알콜, 벤질 벤조에이트, 프로필렌글리콜, 1,3-부틸글리콜 오일이 이용될 수 있으며, 특히, 목화씨 오일, 땅콩 오일, 옥수수 배종 오일, 올리브오일, 피마자 오일 및 참깨 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜 또는 소르비탄의 지방산 에스테르가 이용될 수 있다.When the formulation of the present invention is a solution or emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, 1,3-butyl glycol oil may be used, in particular fatty acid esters of cottonseed oil, peanut oil, corn oil, olive oil, castor oil and sesame oil, glycerol aliphatic esters, polyethylene glycols or sorbitan may be used have.
본 발명의 제형이 현탁액인 경우에는, 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알콜, 폴리옥시에틸렌 소르비톨 에스테르 및 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 또는 트라칸트 등이 이용될 수 있다.When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Crystalline cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.
본 발명의 제형이 비누인 경우에는 담체 성분으로서 지방산의 알칼리 금속 염, 지방산 헤미에스테르 염, 지방산 단백질 히드롤리제이트, 이세티오네이트, 라놀린 유도체, 지방족 알콜, 식물성 유, 글리세롤, 당 등이 이용될 수 있다.When the formulation of the present invention is a soap, an alkali metal salt of a fatty acid, a fatty acid hemiester salt, a fatty acid protein hydrolizate, isethionate, a lanolin derivative, an aliphatic alcohol, a vegetable oil, glycerol, .
본 발명의 화장료 조성물에서, 삼칠 추출물은 구체적으로는 건조 중량으로, 화장료 조성물 총 중량의 0.0001 내지 50 중량%로 포함될 수 있으며, 보다 구체적으로는 0.0005 내지 10 중량%로 포함될 수 있다. 상기 범위 내에서 우수한 피부 보습용 효능을 나타내는 이점이 있으며, 조성물의 제형이 안정화되는 이점이 있다.In the cosmetic composition of the present invention, the extract may be contained in an amount of 0.0001 to 50% by weight, more specifically 0.0005 to 10% by weight, based on the dry weight of the cosmetic composition. There is an advantage of exhibiting excellent skin moisturizing effect within the above range, and there is an advantage that the formulation of the composition is stabilized.
본 발명의 다른 양태로서 삼칠 추출물 또는 이의 분획물을 포함하는 피부 보습용 식품 조성물을 제공한다.Another aspect of the present invention provides a skin-moisturizing food composition comprising a water-soluble extract or a fraction thereof.
본 발명의 삼칠 추출물, 피부 보습은 상기에서 설명한 바와 같다. 상기 식품 조성물은 건강기능식품의 형태로 사용될 수 있으나, 이에 제한되는 것은 아니다.The skin extract of the present invention, skin moisturizing, is as described above. The food composition may be used in the form of a health functional food, but is not limited thereto.
본 발명의 삼칠 추출물을 포함하는 동식물, 이의 추출물, 이의 분획물 또는 이의 가공물의 형태로 포함될 수 있다. 또한 상기 조성물은 유효성분 이외에 식품학적으로 허용 가능한 식품보조첨가제를 포함할 수 있다.May be included in the form of an animal, plant extract, extract thereof, a fraction thereof, or a processed product thereof containing the extract of Trichomonias sp. Of the present invention. The composition may also include a food-acceptable food-aid additive in addition to the active ingredient.
본 발명에 있어서, "식품보조첨가제"란 식품에 보조적으로 첨가될 수 있는 구성요소를 의미하며, 각 제형의 건강기능식품을 제조하는데 첨가되는 것으로서 당업자가 적절히 선택하여 사용할 수 있다. 식품보조첨가제의 예로는 여러 가지 영양제, 비타민, 광물(전해질), 합성 풍미제 및 천연 풍미제 등의 풍미제, 착색제 및 충진제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알콜, 탄산음료에 사용되는 탄산화제 등이 포함되지만, 상기 예들에 의해 본 발명의 식품보조첨가제의 종류가 제한되는 것은 아니다.In the present invention, the term "food-aid additive " means a component that can be added to foods in a supplementary manner, and is appropriately selected and used by those skilled in the art as added to produce health functional foods of each formulation. Examples of food-aid additives include flavors such as various nutrients, vitamins, minerals (electrolytes), synthetic flavors and natural flavors, colorants and fillers, pectic acid and its salts, alginic acid and its salts, organic acids, , a pH adjusting agent, a stabilizer, a preservative, a glycerin, an alcohol, and a carbonating agent used in a carbonated drink. However, the types of the food auxiliary additives of the present invention are not limited by these examples.
본 발명의 식품 조성물에는 건강기능식품이 포함될 수 있다. 본 발명에 있어서, "건강기능식품"이란 인체에 유용한 기능성을 가진 원료나 성분을 사용하여 정제, 캅셀, 분말, 과립, 액상 및 환 등의 형태로 제조 및 가공한 식품을 말한다. 여기서 “기능성”이라 함은 인체의 구조 및 기능에 대하여 영양소를 조절하거나 생리학적 작용 등과 같은 보건용도에 유용한 효과를 얻는 것을 의미한다. 본 발명의 건강기능식품은 당업계에서 통상적으로 사용되는 방법에 의하여 제조 가능하며, 상기 제조시에는 당업계에서 통상적으로 첨가하는 원료 및 성분을 첨가하여 제조할 수 있다. 또한 상기 건강기능식품의 제형 또한 건강기능식품으로 인정되는 제형이면 제한 없이 제조될 수 있다. 본 발명의 식품 조성물은 다양한 형태의 제형으로 제조될 수 있으며, 일반 약품과는 달리 식품을 원료로 하여 약품의 장기 복용 시 발생할 수 있는 부작용 등이 없는 장점이 있고, 휴대성이 뛰어나, 본 발명의 건강기능식품은 피부 보습 효과를 증진시키기 위한 보조제로 섭취가 가능하다.A health functional food may be included in the food composition of the present invention. In the present invention, the term "health functional food" refers to a food prepared and processed in the form of tablets, capsules, powders, granules, liquids and rings using raw materials and components having useful functions in the human body. The term "functional" as used herein means that the structure and function of the human body have a beneficial effect on health uses such as controlling nutrients or physiological actions. The health functional food of the present invention can be prepared by a method commonly used in the art and can be prepared by adding raw materials and ingredients that are conventionally added in the art. In addition, the formulations of the above health functional foods may also be manufactured without limitations as long as they are acceptable as health functional foods. The food composition of the present invention can be manufactured in various formulations, and unlike general pharmaceuticals, it has an advantage of being free from side effects that may occur when a food is used as a raw material for a long period of time, and is excellent in portability. Health functional foods can be supplemented to enhance skin moisturizing effect.
본 발명의 건강기능식품이 취할 수 있는 형태에는 제한이 없으며, 통상적인 의미의 식품을 모두 포함할 수 있고, 기능성 식품 등 당업계에 알려진 용어와 혼용 가능하다. 아울러 본 발명의 건강기능식품은 당업자의 선택에 따라 식품에 포함될 수 있는 적절한 기타 보조성분과 공지의 첨가제를 혼합하여 제조할 수 있다. 첨가할 수 있는 식품의 예로는 육류, 소세지, 빵, 쵸코렛, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 스프, 음료수, 차, 드링크제, 알콜 음료 및 비타민 복합제 등이 있으며, 본 발명에 따른 화학식 1로 표시되는 화합물을 주성분으로 하여 제조한 즙, 차, 젤리 및 주스 등에 첨가하여 제조할 수 있다. 또한 동물을 위한 사료로 이용되는 식품도 포함한다.The form of the health functional food of the present invention is not limited, and may include all foods in the conventional meaning, and may be used in combination with terms known in the art such as functional foods. In addition, the health functional food of the present invention can be prepared by mixing other suitable auxiliary ingredients, which may be included in food, according to the selection of a person skilled in the art, and known additives. Examples of foods that can be added include dairy products, such as meat, sausage, bread, chocolates, candies, snacks, confectionery, pizza, ramen, other noodles, gums, ice cream, various soups, drinks, tea, Vitamin complex, and the like, and can be prepared by adding to juice, tea, jelly, juice and the like prepared by using the compound represented by the formula (1) according to the present invention as a main component. It also includes foods used as feed for animals.
본 발명의 또 다른 양태로서 삼칠 추출물 또는 이의 분획물을 포함하는 피부 보습용 의약외품 조성물을 제공한다.In another aspect of the present invention, there is provided a quasi-drug composition for skin moisturization, comprising the extract or extract thereof.
본 발명의 삼칠 추출물, 피부 보습은 상기에서 설명한 바와 같다.The skin extract of the present invention, skin moisturizing, is as described above.
본 발명의 의약외품 조성물에는 상기 성분 외에 필요에 따라 약학적으로 허용 가능한 담체, 부형제 또는 희석제를 더욱 포함할 수 있다. 상기 약학적으로 허용 가능한 담체, 부형제 또는 희석제는 본 발명의 효과를 해하지 않는 한 제한되지 않으며, 예를 들어 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제, 윤활제, 감미제, 방향제, 보존제 등을 포함할 수 있다.The quasi-drug composition of the present invention may further contain a pharmaceutically acceptable carrier, excipient or diluent as necessary in addition to the above components. The pharmaceutically acceptable carrier, excipient or diluent is not limited as long as the effect of the present invention is not impaired, and examples thereof include fillers, extenders, binders, wetting agents, disintegrants, surfactants, lubricants, sweeteners, .
본 발명의 약학적으로 허용 가능한 담체, 부형제 또는 희석제의 대표적인 예로는, 락토즈, 덱스트로스, 슈크로스, 솔비톨, 만니톨, 자일리톨, 말티톨, 전분, 젤라틴, 글리세린, 아카시아 고무, 알지네이트, 칼슘포스페이트, 칼슘카보네이트, 칼슘실리케이트, 셀룰로즈, 메틸 셀룰로즈, 미정질 셀룰로즈, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 탈크, 마그네슘 스테아레이트, 광물유, 프로필렌글리콜, 폴리에틸렌글리콜, 식물성 오일, 주사가능한 에스테르, 위텝솔, 마크로골, 트윈 61, 카카오지, 라우리지 등을 들 수 있다.Representative examples of the pharmaceutically acceptable carrier, excipient or diluent of the present invention include lactose, dextrose, sucrose, sorbitol, mannitol, xylitol, maltitol, starch, gelatin, glycerin, acacia rubber, alginate, calcium phosphate, calcium Methyl cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, mineral oil, propylene glycol, polyethylene glycol, vegetable oils such as sodium carboxymethylcellulose, , Injectable ester, witepsol, macrogol, tween 61, cacao paper, and laurie paper.
또한, 본 발명의 삼칠 추출물을 의약외품으로 사용하는 경우, 추가로 동일 또는 유사한 기능을 나타내는 유효성분을 1종 이상 함유할 수 있다. 예컨대, 공지의 보습 성분을 포함할 수 있을 것이다. 추가적인 보습 성분을 포함하게 되면 본 발명의 조성물의 보습 효과는 더욱 증가될 수 있다. 상기 성분 추가 시에는 복합 사용에 따른 피부 안전성, 제형화의 용이성, 유효성분들의 안정성을 고려할 수 있다. 상기 의약외품 조성물은 당업계에 공지된 보습 성분으로서, 레티노산, TGF, 동물 태반 유래의 단백질, 베툴린산 및 클로렐라 추출물; 및 이들의 유도체와 각종 식물 추출물로 구성되는 군으로부터 선택되는 1종 또는 2종 이상의 성분을 추가로 포함할 수 있다. 추가 성분은 전체 조성물 중량에 대하여 0.0001 중량% 내지 10 중량%로 포함될 수 있을 것이며, 상기 함량 범위는 피부 안전성, 본 발명의 삼칠 추출물의 제형화 시의 용이성 등의 요건에 따라 조절될 수 있을 것이다.In addition, when the extract of the present invention is used as a quasi-drug, it may further contain one or more active ingredients exhibiting the same or similar functions. For example, a known moisturizing component may be included. The addition of an additional moisturizing component can further enhance the moisturizing effect of the composition of the present invention. When the above ingredients are added, skin safety, easiness of formulation, and stability of effective ingredients can be considered according to the combined use. The quasi-drug composition is a moisturizing ingredient known in the art and includes retinoic acid, TGF, protein from animal placenta, betulinic acid and chlorella extract; And derivatives thereof, and various plant extracts. ≪ Desc / Clms Page number 2 > The additional ingredient may be included in an amount of 0.0001 wt% to 10 wt% based on the total weight of the composition, and the content range may be adjusted according to requirements such as skin safety, ease of formulation of the extract of the present invention.
본 발명의 의약외품 조성물은 소독 청결제, 샤워폼, 연고액, 물티슈, 코팅제 등을 예시할 수 있으나 이에 제한되는 것이 아니며, 의약외품의 제제화 방법, 용량, 이용방법, 구성성분 등은 기술분야에 공지된 통상의 기술로부터 적절히 선택될 수 있다.The quasi-drug composition of the present invention can be exemplified by a disinfectant cleaner, a shower foam, a softener solution, a wet tissue, a coating agent, and the like. The formulation method, dosage, usage method, And the like.
또한, 본 발명의 삼칠 추출물은 개체의 피부에 도포하는 단계를 포함하는, 피부 보습 방법에 사용될 수 있다. 상기 개체는 쥐, 가축, 인간 등을 포함하는 포유동물을 제한 없이 포함한다.In addition, the trichlorm extract of the present invention can be used in skin moisturizing methods, including applying to the skin of an individual. The subject includes, without limitation, mammals including rats, livestock, humans, and the like.
본 발명의 삼칠 추출물 또는 이의 분획물을 유효성분으로 포함하는 화장료 조성물은 피부 보습 효능이 우수하다. 또한, 본 발명의 삼칠 추출물 또는 이의 분획물을 포함하는 조성물은 피부 보습용 식품 조성물 및 의약외품 조성물로서 사용할 수 있다.The cosmetic composition comprising the extract of the present invention or a fraction thereof as an active ingredient has excellent skin moisturizing effect. In addition, the composition comprising the extract of the present invention or a fraction thereof can be used as a skin-moisturizing food composition and a quasi-drug composition.
이하, 실시예를 통하여 본 발명의 구성 및 효과를 더욱 상세히 설명하고자 한다. 이들 실시예는 오로지 본 발명을 예시하기 위한 것일 뿐 본 발명의 범위가 이들 실시예에 의해 제한되는 것은 아니다.Hereinafter, the constitution and effects of the present invention will be described in more detail through examples. These embodiments are only for illustrating the present invention, and the scope of the present invention is not limited by these embodiments.
제조예Manufacturing example : 삼칠 추출물의 제조 : Preparation of Tricholoma extract
삼칠을 건조하여 세절(細切)한 후, 건조 중량 100g을 플라스크에 넣고 추출용매(증류수) 1000g으로 3일간 냉침하여 추출하였다. 냉침한 추출물을 0.2㎛ 기공 크기를 갖는 필터로 여과하여 삼칠 추출물을 제조하였다.After drying for 3 days, the flakes were put into a flask and the mixture was cooled with 1000 g of an extraction solvent (distilled water) for 3 days and extracted. The frozen extract was filtered with a filter having a pore size of 0.2 탆 to prepare an extract.
실시예Example : 에센스 제조 : Essence manufacturing
제조예의 삼칠 추출물을 포함하는 에센스를 제조하였다. 상세한 조성(중량%)는 하기 표 1에 나타내었다.An essence containing a trichotomous extract of Preparation Example was prepared. The detailed composition (% by weight) is shown in Table 1 below.
주1. 카르복시비닐폴리머 - 미국 비.에프.굿리치(B.F.Goodrich)사의 카보폴 941(Carbopol 941) 1 중량% 수용액Note 1 . Carboxyvinyl polymer - a 1% by weight aqueous solution of Carbopol 941 from BF Goodrich, USA
주2. 모노스테아린산소르비탄 - 영국 아이시아이(ICI)사이 아라셀 60(Arlacel 60)Note 2 . Monostearic acid sorbitan - ICI Sialasel 60 (Arlacel 60)
주3. 이소세틸옥타노에이트 - 일본 니혼 고쿄 알코올(Nihon KoKyu Alcohol)사의 아이시이에이치(ICEH) Note 3 . Isocetyl Octanoate - Ishihi (ICEH) of Nihon KoKyu Alcohol Co.,
비교예Comparative Example : 삼칠 추출물을 포함하지 않는 에센스 : Essence that does not contain trillion extract
삼칠 추출물을 포함하지 않는 것을 제외하고는 실시예와 동일하게 제조하였다. The extract was prepared in the same manner as in Example except that the extract was not included.
실험예Experimental Example : 수분 : moisture 보유능Possession 평가 evaluation
실시예 및 비교예의 에센스의 피부 보습력을 평가하기 위하여 상기 실시예 및 비교예의 에센스를 각각 피부에 정량 도포한 후 각질층의 수분 보유량을 측정하고 이를 평가하는 방법을 사용하였다. In order to evaluate the skin moisturizing ability of the essences of Examples and Comparative Examples, the essence of each of the above Examples and Comparative Examples was applied to the skin, and then the moisture content of the stratum corneum was measured and evaluated.
측정 기기로는 피부수분함량 측정기(스킨 설피스 하이그로미터, skin surface hygrometer, 모델명: SKICON-200, 일본 IBS사 제품)를 이용하였다. As a measuring device, a skin moisture meter (skin surface hygrometer, model name: SKICON-200, manufactured by IBS Japan) was used.
구체적으로 25℃, 상대습도 45의 항온 항습실에서 실시예 및 비교예의 에센스를 각각 20명의 피시험자의 팔의 안쪽에 일정량(2 mg/㎠) 도포한 후 잘 문지르고, 평가 전의 수분 보유능을 기준으로 1시간과 3시간 후의 수분 증가율(%)을 측정하여 보습 효과를 평가하였다. 얻어진 결과를 하기 표 2에 나타내었다.Specifically, in a constant temperature and humidity chamber at 25 ° C and a relative humidity of 45, a certain amount (2 mg / cm 2) of the essences of the examples and the comparative examples was applied to the inside of each arm of 20 subjects respectively and rubbed well. And the moisture increase rate (%) after 3 hours was measured to evaluate the moisturizing effect. The obtained results are shown in Table 2 below.
상기 표 2에 나타낸 바와 같이, 본 발명의 실시예의 에센스는 비교예의 에센스에 비해 도포 1시간 후 및 3시간 후의 수분 보유 증가율이 높은 바 보습 효과가 우수함을 알 수 있었다. As shown in Table 2, it was found that the essence of the example of the present invention is superior to the essence of the comparative example in that the moisture retention increase rate is higher and the moisture retention effect is higher after one hour and three hours after the application.
Claims (4)
A cosmetic composition for moisturizing the skin, comprising the extract as an active ingredient or a fraction thereof.
The composition according to claim 1, wherein the composition is at least one selected from the group consisting of a solution, an external ointment, a cream, a foam, a nutritional lotion, a softening longevity, a pack, a flexible water, a latex, a makeup base, an essence, Formulations selected from the group consisting of sunscreen creams, sun oil, suspensions, emulsions, pastes, gels, lotions, powders, soaps, surfactant-containing cleansing, oils, powder foundations, emulsion foundations, wax foundations, patches and sprays Wherein the cosmetic composition for skin moisturizes.
A composition for skin moisturizing, comprising as an active ingredient an extract or a fraction thereof.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160171794A KR20180069527A (en) | 2016-12-15 | 2016-12-15 | Cosmetic Composition for skin moisturizing comprising Panax notoginsengs extracts |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR1020160171794A KR20180069527A (en) | 2016-12-15 | 2016-12-15 | Cosmetic Composition for skin moisturizing comprising Panax notoginsengs extracts |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| KR20180069527A true KR20180069527A (en) | 2018-06-25 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| KR1020160171794A KR20180069527A (en) | 2016-12-15 | 2016-12-15 | Cosmetic Composition for skin moisturizing comprising Panax notoginsengs extracts |
Country Status (1)
| Country | Link |
|---|---|
| KR (1) | KR20180069527A (en) |
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2016
- 2016-12-15 KR KR1020160171794A patent/KR20180069527A/en active Search and Examination
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