KR20180062420A - Composition for eliminating hangover comprising fermented Allium hookeri as effective component - Google Patents

Composition for eliminating hangover comprising fermented Allium hookeri as effective component Download PDF

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KR20180062420A
KR20180062420A KR1020170162525A KR20170162525A KR20180062420A KR 20180062420 A KR20180062420 A KR 20180062420A KR 1020170162525 A KR1020170162525 A KR 1020170162525A KR 20170162525 A KR20170162525 A KR 20170162525A KR 20180062420 A KR20180062420 A KR 20180062420A
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fermented
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hangover
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김유석
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농업회사법인 황금나무(주)
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    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L29/00Foods or foodstuffs containing additives; Preparation or treatment thereof
    • A23L29/06Enzymes
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
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    • A23L33/10Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
    • A23L33/105Plant extracts, their artificial duplicates or their derivatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00Food compositions, function of food ingredients or processes for food or foodstuffs
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2200/00Function of food ingredients
    • A23V2200/30Foods, ingredients or supplements having a functional effect on health
    • A23V2200/334Foods, ingredients or supplements having a functional effect on health treating the effects of consuming alcohol, narcotics or other addictive behavior, e.g. treating hangover or reducing blood alcohol levels
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/11Lactobacillus
    • A23V2400/113Acidophilus
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/21Streptococcus, lactococcus
    • A23V2400/249Thermophilus
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/41Pediococcus
    • A23V2400/413Acidilactici
    • AHUMAN NECESSITIES
    • A23FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23VINDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2400/00Lactic or propionic acid bacteria
    • A23V2400/51Bifidobacterium
    • A23V2400/533Longum
    • A23Y2220/03
    • A23Y2240/75
    • A23Y2280/15
    • A23Y2300/55

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Abstract

The present invention relates to a composition comprising fermented Allium hookeri as an effective component, wherein the fermented Allium hookeri is effective in eliminating a hangover because the fermented Allium hookeri can reduce the content of ethanol and acetaldehyde increased by alcohol consumption by reducing the content of blood alcohol and enhancing the content of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH). Therefore, the composition of the present invention can be usefully used as health functional food for eliminating the hangover, particularly as a beverage material for eliminating the hangover.

Description

발효삼채를 유효성분으로 함유하는 숙취해소용 조성물{Composition for eliminating hangover comprising fermented Allium hookeri as effective component}Technical Field [0001] The present invention relates to a composition for fermented Allium hooker as effective component,

본 발명은 발효삼채를 유효성분으로 함유하는 숙취해소용 조성물에 관한 것이다.The present invention relates to a composition for hangover decoy comprising fermented trihydrate as an active ingredient.

과다한 음주는 일시적으로 두근거림, 두통, 갈증, 멀미, 위장장애, 설사 등의 숙취현상을 유발한다. 일반적으로 체내로 들어온 에탄올은 세포질 내의 알코올 탈수소효소(alcohol dehydrogenase, ADH)와 알데하이드 탈수소효소(aldehyde dehydrogenase, ALDH)의 작용에 의해 아세테이트로 전환되어 순환계를 통해 간세포 밖으로 배설되는데, 특히 에탄올 대사산물인 아세트알데하이드는 반응성이 높고 독성이 강하여 숙취 및 알코올성 부작용의 주원인 물질로 알려져 있다. 따라서 알코올 분해 및 아세트알데하이드 분해 촉진을 통한 숙취 해소 방법들이 개발되어 왔다. 그 중에서도 천연물을 이용하는 방법들이 주목을 받고 있다. 잘 알려진 숙취 해소용 천연물로는 지구자(헛개나무 열매), 천궁, 감초, 갈근, 진피, 모과, 다시마, 녹차, 매실, 더덕 등이 있으며, 이들을 단독 또는 조합하여 숙취해소 효과가 있는 식품 또는 음료를 제조하여 시판하고 있다. 하지만, 지나친 광고에 비해 그 효과가 미미한 실정으로 보다 효과적인 숙취해소용 음료에 대한 시장의 요구는 여전하다.Excessive drinking may temporarily cause hangover, headache, thirst, motion sickness, gastrointestinal disturbances, and diarrhea. In general, ethanol enters the body via the action of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) in the cytoplasm, and is excreted through the circulation system into the hepatocyte. Particularly, ethanol, which is an ethanol metabolite, Aldehydes are highly reactive and highly toxic and are known to be the major source of hangover and alcoholic side effects. Therefore, methods for dissolving hangover by promoting alcohol decomposition and acetaldehyde decomposition have been developed. Among them, methods using natural products are attracting attention. There are well-known natural products for relieving hangover, such as Chungja (Hovenia dulcis), Tongkung, Liquorice, Puerariae, Dermis, Maquinaceae, Kelp, Green tea, Plum and Doduck. Are manufactured and marketed. However, the effect is insignificant compared to excessive advertising, so there is still a demand for a more effective hangover drink for the market.

한편, 삼채(Allium hokeri)는 해발 1,400~4,200m의 고랭지에 자생하는 식물로 미얀마 등지에서는 국민채소로 알려져 있으며, 단맛, 쓴맛, 매운맛이 난다고 하여 삼채(三菜)라고 부르기도 하며, 인삼맛이 난다고 하여 삼채(蔘菜)라고 부르기도 한다. 2010년 국내 도입되어 2011년 경남 하동, 진주, 경기 하남 등의 6곳에서 시험 재배에 성공하였고 2012년 김제시, 고창군, 신안군, 하동군, 제주도, 합천군 등에서 계약재배를 비롯한 강원, 충청, 경북, 경기 등의 약 1,000여 농가에서 재배하고 있다. 2012년 대량 재배를 시작하여 한국에서도 재배할 수 있다는 점이 입증되어 농촌지역의 신소득 작물로서 주목받고 있다. 삼채는 우리나라의 파, 양파, 부추, 마늘처럼 쉽게 식용되고 있는 채소이고, 민간처방으로 다양한 염증질환과 암 질환 등에 사용되고 있다. 삼채는 칼슘, 철, 아연, 망간 등 미네랄 성분과 함께 질소 및 섬유질이 풍부하게 함유되어 있어 골격과 치아형성, 혈액생성 및 정혈작용, 정력증강, 신체균형조절, 고혈압, 동맥경화, 변비예방 및 배변촉진 등 다양한 효능을 가진다.On the other hand, Allium hokeri is a plant that grows in the highlands of 1,400 ~ 4,200m above sea level. It is also known as a national vegetable in Myanmar. It is also called "三菜" because it has sweetness, bitter taste and spicy taste. It is also called 玄 菜. It was introduced in Korea in 2010, and successfully cultivated in 6 sites including Hadong, Jinju and Gyeongnam in 2011. In 2012, it was cultivated in Gimje, Gokchang, Sinan, Hadong, Jeju and Hacchon. Is cultivated in about 1,000 farms. It has been proven that it can be cultivated in Korea since the start of mass cultivation in 2012, and it is attracting attention as a new income crop in rural areas. It is a vegetable that is easily edible like Korean wave, onion, leek and garlic. It is used in various inflammatory diseases and cancer diseases by private prescription. It is rich in nitrogen and fiber as well as minerals such as calcium, iron, zinc, and manganese, and is rich in nitrogen and fiber, so that bone and tooth formation, blood production and blood circulation, energetic enhancement, body balance control, hypertension, arteriosclerosis, And has various effects such as promotion.

숙취해소 관련 기술의 일례로 한국등록특허 제1326413호에는 숙취예방, 숙취해소 및 아세트알데하이드 유발 질환 예방용 조성물이 알려져 있고, 한국등록특허 제0442771호에 숙취해소 효과를 갖는 음료 및 그 제조 방법이 개시되어 있으며, 한국등록특허 제1601947호에 땅콩 새싹 추출물을 포함하는 숙취해소 윰료 조성물 및 그 제조방법이 개시되어 있으나, 본 발명의 발효 삼채를 유효성분으로 하는 숙취해소용 조성물에 대해 개시된 바 없다. Korean Patent No. 1326413 discloses a composition for prevention of hangover, hangover and acetaldehyde-induced diseases, and Korean Patent No. 0442771 discloses a beverage having a hangover effect and a preparation method thereof. Korean Patent No. 1601947 discloses a hangover relief composition containing a peanut sprout extract and a preparation method thereof. However, the hangover detoxification composition containing the fermented triangle of the present invention as an active ingredient has not been disclosed.

본 발명은 상기와 같은 요구에 의해 도출된 것으로서, 발효삼채를 유효성분으로 함유하는 숙취해소용 조성물을 제공하고, 상기 발효삼채가 혈중 알코올 함량 을 감소시키고, 알코올 탈수소효소(alcohol dehydrogenase, ADH) 및 알데하이드 탈수소효소(aldehyde dehydrogenase, ALDH)의 함량을 증진시킨다는 것을 확인함으로써, 본 발명을 완성하였다.The present invention has been made in view of the above-mentioned needs, and an object of the present invention is to provide a hangover detoxifying composition containing a fermented triangle as an active ingredient, and the fermented triangle reduces the blood alcohol content and the alcohol dehydrogenase (ADH) And that the content of aldehyde dehydrogenase (ALDH) is increased, thus completing the present invention.

상기 목적을 달성하기 위하여, 본 발명은 발효삼채를 유효성분으로 함유하는 숙취해소용 건강기능식품 조성물을 제공한다.In order to achieve the above object, the present invention provides a health functional food composition for hungry snails containing a fermented triangle as an active ingredient.

본 발명은 발효삼채를 유효성분으로 함유하는 숙취해소용 조성물에 관한 것으로, 발효삼채는 혈중 알코올 함량을 감소시키고, 알코올 탈수소효소(alcohol dehydrogenase, ADH) 및 알데하이드 탈수소효소(aldehyde dehydrogenase, ALDH)의 함량을 증진시킴으로써, 알코올 섭취에 의해 증가된 알코올 및 알코올 분해 중간산물인 아세트알데하이드를 감소시킬 수 있으므로 숙취해소에 효과가 있는 것이다. 따라서, 숙취해소용 건강기능식품, 특히 숙취해소용 음료로 이용가능성이 매우 크다.The present invention relates to a composition for hangover decoys containing fermented triangles as an active ingredient, wherein the fermented triangles reduce the blood alcohol content and reduce the content of alcohol dehydrogenase (ADH) and aldehyde dehydrogenase (ALDH) Is effective in decreasing hangover by reducing acetaldehyde, which is an alcohol and alcohol decomposition intermediate, which is increased by alcohol ingestion. Therefore, it is very likely to be used as a health functional food for hangover, especially hangover and small-sized drinks.

본 발명은 발효삼채를 유효성분으로 함유하는 숙취해소용 건강기능식품 조성물에 관한 것이다. 상기 발효삼채의 발효는 유산균 배양액과 과일효소액을 이용하는 것이 바람직하지만 이에 한정하지 않는다.The present invention relates to a health functional food composition for hangover marrow containing fermented trihydrate as an active ingredient. Preferably, the fermented triplex is fermented using a culture solution of a lactic acid bacteria and a fruit enzyme solution, but is not limited thereto.

본 발명에서 발효삼채의 제조는 유산균 배양액과 과일 효소액을 혼합한 발효액에 삼채 추출물의 건조분말을 첨가하여 30~40℃의 온도 조건하에서 60~84시간동안 발효하는 것이 바람직하지만 이에 한정하는 것은 아니다.In the present invention, the fermentation of the fermented triangle is preferably performed by adding the dried powder of the triple extract to the fermentation broth obtained by mixing the culture of the lactic acid bacteria and the fruit enzyme solution, and fermenting the fermented broth for 60 to 84 hours at a temperature of 30 to 40 ° C.

상기 유산균의 바람직한 일례로는 페디오코커스 애시디락티시(Pediococcus acidilactici), 락토바실러스 애씨도필러스(Lactobacillus acidophilus MG501), 비피도박테리움 롱검(Bifidobacterium longum MG723), 엔테로코커스 패시움(Enterococcus faecium MG89) 및 스트렙토코커스 써모필러스(Streptococcus thermophilus MG510) 중 어느 하나 이상인 것이지만 이에 한정하는 것은 아니다.Preferred example of said lactic acid bacteria is Lactococcus Phedi o her CD rakti when (Pediococcus acidilactici), Lactobacillus aessi FIG filler's (Lactobacillus acidophilus MG501), Bifidobacterium ronggeom (Bifidobacterium longum MG723), Enterococcus passive help (Enterococcus faecium MG89) and Streptococcus thermophilus MG510. However, the present invention is not limited thereto.

상기 과일 효소액은 사과, 오디, 블루베리, 오미자, 레몬, 유자,귤, 오렌지, 자몽, 키위. 파인애플, 복숭아, 포도 및 매실 중에서 선택된 하나 이상의 과일을 이용하여 제조한 효소액일 수 있으나 이에 한정하는 것은 아니며, 경우에 따라 과일 효소액을 첨가하지 않고, 영양분으로 설탕 등의 당분으로 대체하는 것도 가능하다. The above-mentioned fruit enzyme solution is apple, audi, blueberry, omija, lemon, citron, tangerine, orange, grapefruit, kiwi. Pineapple, peach, grape, and plum, but it is not limited thereto. In some cases, it is also possible to substitute sugar as a nutrient without adding a fruit enzyme solution.

상기 숙취해소는 메스꺼움, 구토, 복통, 설사, 두통, 갈증 또는 위장장애의 해소를 의미하지만 이에 한정하지 않으며, 과음한 후 나타나는 일반적인 현상을 포괄할 수 있다. 상기 발효삼채는 혈중 알코올 탈수소효소(alcohol dehydrogenase) 및 알데하이드 탈수소효소(aldehyde dehydrogenase)의 함량을 증가시킬 수 있다.The hangover resolution means eliminating nausea, vomiting, abdominal pain, diarrhea, headache, thirst or gastrointestinal disorder, but it is not limited to this and can include general phenomena that occur after overeating. The fermented syrup can increase the content of alcohol dehydrogenase and aldehyde dehydrogenase in the blood.

본 발명의 건강기능식품 조성물은 분말, 과립, 환, 정제, 캡슐, 캔디, 시럽 발포정 및 음료 중에서 선택된 어느 하나의 제형으로 제조될 수 있으며, 바람직하게는 발포정 또는 음료로 제조하는 것이지만, 이에 제한되지 않는다. 본 발명의 건강기능식품 조성물은 숙취해소를 예방하거나 개선하기 위해 섭취할 수 있는 것이면 특별히 제한되지 않는다. 본 발명의 건강기능식품 조성물을 식품첨가물로 사용하는 경우, 상기 건강기능식품 조성물을 그대로 첨가하거나 다른 식품 또는 식품성분과 함께 사용될 수 있고, 통상적인 방법에 따라 적절하게 사용될 수 있다. 유효성분은 그의 사용 목적(예방 또는 개선)에 따라 적절하게 사용될 수 있다. 일반적으로, 식품 또는 음료의 제조시 본 발명의 건강기능식품 조성물에 대하여 15 중량부 이하, 바람직하게는 10 중량부 이하의 양으로 첨가된다. 그러나 건강 조절을 목적으로 하는 장기간의 섭취의 경우에는 상기 양은 상기 범위 이하일 수 있으며, 안전성 면에서 아무런 문제가 없기 때문에 유효성분은 상기 범위 이상의 양으로 사용될 수 있다. 상기 식품의 종류에는 특별한 제한은 없다. 상기 건강기능식품 조성물을 첨가할 수 있는 식품의 예로는 육류, 소시지, 빵, 초콜릿, 캔디류, 스낵류, 과자류, 피자, 라면, 기타 면류, 껌류, 아이스크림류를 포함한 낙농제품, 각종 수프, 음료수, 차 드링크제, 알코올 음료 및 비타민 복합제 등이 있으며, 통상적인 의미에서의 건강식품을 모두 포함한다. 또한, 본 발명의 건강기능식품 조성물은 식품, 특히 기능성 식품으로 제조될 수 있다. 본 발명의 기능성 식품은 식품 제조 시에 통상적으로 첨가되는 성분을 포함하며, 예를 들어, 단백질, 탄수화물, 지방, 영양소 및 조미제를 포함한다. 예컨대, 드링크제로 제조되는 경우에는 유효성분 이외에 천연 탄수화물 또는 향미제를 추가 성분으로서 포함할 수 있다. 상기 천연 탄수화물은 모노사카라이드(예컨대, 글루코오스, 프럭토오스 등), 디사카라이드(예컨대, 말토스, 수크로오스 등), 올리고당, 폴리사카라이드(예컨대, 덱스트린, 시클로덱스트린 등) 또는 당알코올(예컨대, 자일리톨, 소르비톨, 에리쓰리톨 등)인 것이 바람직하다. 상기 향미제는 천연 향미제(예컨대, 타우마틴, 스테비아 추출물 등)와 합성 향미제(예컨대, 사카린, 아스파르탐 등)를 이용할 수 있다. 상기 건강기능식품 조성물 외에 여러 가지 영양제, 비타민, 전해질, 풍미제, 착색제, 펙트산 및 그의 염, 알긴산 및 그의 염, 유기산, 보호성 콜로이드 증점제, pH 조절제, 안정화제, 방부제, 글리세린, 알코올, 탄산음료에 사용되는 탄산화제 등을 더 함유할 수 있다.
The health functional food composition of the present invention may be prepared into any one form of powder, granule, ring, tablet, capsule, candy, syrup foamable beverage and beverage, preferably foamed beverage or beverage, It is not limited. The health functional food composition of the present invention is not particularly limited as long as it can be ingested to prevent or ameliorate hangover. When the health functional food composition of the present invention is used as a food additive, the health functional food composition may be added as it is, or may be used together with other food or food ingredients, and suitably used according to a conventional method. The active ingredient may be suitably used depending on its intended use (prevention or improvement). Generally, in the production of food or beverage, it is added in an amount of not more than 15 parts by weight, preferably not more than 10 parts by weight, based on the health functional food composition of the present invention. However, in the case of long-term intake for the purpose of controlling health, the amount may be less than the above range, and since there is no problem in terms of safety, the active ingredient may be used in an amount exceeding the above range. There is no particular limitation on the kind of the food. Examples of foods to which the health functional food composition can be added include meat products, sausages, breads, chocolate, candies, snacks, confectionery, pizza, ramen noodles, other noodles, gums, dairy products including ice cream, various soups, Alcoholic beverages, and vitamin complexes, all of which include health foods in a conventional sense. In addition, the health functional food composition of the present invention can be produced as a food, particularly a functional food. The functional food of the present invention includes components that are ordinarily added in food production, and includes, for example, proteins, carbohydrates, fats, nutrients, and seasonings. For example, when it is made of a drink, it may contain, in addition to the active ingredient, a natural carbohydrate or a flavoring agent as an additional ingredient. The natural carbohydrate may be selected from the group consisting of monosaccharides (e.g., glucose, fructose, etc.), disaccharides (e.g., maltose, sucrose etc.), oligosaccharides, polysaccharides (e.g., dextrin, cyclodextrin, , Xylitol, sorbitol, erythritol, etc.). The flavoring agent may be a natural flavoring agent (e.g., tau Martin, stevia extract, etc.) and a synthetic flavoring agent (e.g., saccharin, aspartame, etc.). In addition to the above-mentioned health functional food composition, it is possible to use various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and salts thereof, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, preservatives, glycerin, A carbonating agent used in beverages, and the like.

이하, 실시예를 이용하여 본 발명을 더욱 상세하게 설명하고자 한다. 이들 실시예는 오로지 본 발명을 보다 구체적으로 설명하기 위한 것으로 본 발명의 범위가 이들에 의해 제한되지 않는다는 것은 당해 기술분야에서 통상의 지식을 가진 자에게 있어 자명한 것이다.
Hereinafter, the present invention will be described in more detail with reference to Examples. It is to be understood by those skilled in the art that these embodiments are merely illustrative of the present invention and that the scope of the present invention is not limited thereto.

실시예Example 1.  One. 발효삼채의Fermented 제조 Produce

삼채는 전라북도 순창군 구림면 구암리 농업회사법인 황금나무(주) 직영농장에서 형태학적 평가를 통해 동정된 것을 사용하였다. 삼채의 뿌리를 수세한 후 동결건조하였고, 분쇄기를 이용하여 분쇄한 후, 시료 100g에 중량 대비 20배의 70%(v/v) 발효 주정을 가하고, 실온에서 24시간씩 2회 반복하여 교반 추출하였다.Samcheon was identified by morphological evaluation in direct farm of Golden Tree Co., Ltd. The roots of the triplex were washed with water and then lyophilized. The mixture was pulverized using a pulverizer, and a 20% 70% (v / v) fermentation alcohol was added to 100 g of the sample. The mixture was stirred twice at room temperature for 24 hours, Respectively.

추출물은 ADVANTEC 페이퍼(NO. 6)를 이용하여 여과하였고, 감압 농축기(EYELA N-1000, Riakikai Co., Ltd., 도쿄, 일본)를 사용하여 농축한 후 동결건조하였다. The extract was filtered using ADVANTEC paper (No. 6), concentrated using a vacuum concentrator (EYELA N-1000, Riakikai Co., Ltd., Tokyo, Japan) and lyophilized.

발효삼채를 제조하기 위해, 상기 삼채 추출물의 동결건조물을 페디오코커스 애시디락티시(Pediococcus acidilactici) 및 사과 효소액이 함유된 배지에서 33~37℃를 유지하면서, 60~84시간 동안 발효하여 실험에 사용하였다.
In order to prepare the fermented triplex, the lyophilized product of the above-mentioned triplex extract was fermented for 60 to 84 hours in a medium containing Pediococcus acidilactici and apple enzyme solution at 33 to 37 ° C, Respectively.

실시예Example 2. 발효  2. Fermentation 삼채Triptych 투여에 의한 혈중 에탄올, 알코올 탈수소효소( Ethanol in the blood by administration, alcohol dehydrogenase ( alcoholalcohol dehydrogenase,  dehydrogenase, ADHADH ) 및 ) And 알데하이드Aldehyde 탈수소효소( Dehydrogenase ( aldehydealdehyde dehydrogenasedehydrogenase , , ALDHALDH )의 )of box 량 변화 확인Confirmation of quantity change

생후 7주령의 수컷 ICR 마우스에 에탄올 및 실시예 1의 발효삼채를 투여하여 본 발명의 발효삼채에 의한 숙취해소 효과를 확인하였다.Ethanol and the fermented trichomes of Example 1 were administered to male ICR mice at 7 weeks of age to confirm the hangover resolution effect of the fermented triangle of the present invention.

실험을 위해 각 마우스는 에탄올을 섭취하지 않은 음성대조군, 에탄올 및 증류수 섭취군(대조군), 에탄올 및 발효삼채 섭취군으로 구별하였으며, 에탄올 4g/㎏과 함께 증류수는 10㎖/㎏, 발효삼채는 480㎎/㎏을 경구투여하였다. For the experiment, each mouse was divided into a negative control group without ethanol, ethanol and distilled water (control group), ethanol and fermented trifoliate group, and ethanol 4 g / kg with distilled water 10 ml / kg, Mg / kg < / RTI >

혈중 에탄올 함량, ADH 및 ALDH의 함량은 에탄올 및 발효삼채 섭취 3시간 경과 후 안와정맥총으로부터 혈액 1㎖를 채취하여 각각의 분석 키트를 이용하여 측정하였다. Serum ethanol, ADH, and ALDH contents were measured by using each assay kit after collecting 1 ml of blood from the orbital vein at 3 hours after ethanol and fermentation.

그 결과, 표 1에 나타난 바와 같이 에탄올 섭취에 의해 증가된 혈중 에탄올 함량은 발효삼채 섭취에 의해 감소하였고, 발효삼채를 함께 섭취한 군의 ADH 및 ALDH의 함량은 에탄올 투여군에 비해 증가하였다. 따라서, 발효삼채를 섭취함으로써, 알코올 대사가 빨라지고, 숙취해소 효과가 있음을 확인할 수 있었다. As a result, as shown in Table 1, the ethanol content of the blood increased with ethanol intake, and the amount of ADH and ALDH in the group fed with fermented trihydrate increased compared with the ethanol group. Therefore, it was confirmed that the consumption of the fermented trihydrate accelerated the metabolism of alcohol and had a hangover resolution effect.

알코올 함량
(㎎/dl)
Alcohol content
(Mg / dl)
ADH
(㎎/dl)
ADH
(Mg / dl)
ALDH
(㎎/dl)
ALDH
(Mg / dl)
음성대조군Negative control group 1.60±0.311.60 0.31 103.26±4.51103.26 + 4.51 0.14±0.020.14 + 0.02 알코올+증류수Alcohol + distilled water 150.24±0.31150.24 0.31 90.38±5.5190.38 + - 5.51 0.34±0.010.34 ± 0.01 알코올+발효삼채Alcohol + fermented tea 68.29±3.7168.29 + - 3.71 116.26±5.49116.26 ± 5.49 0.54±0.030.54 + 0.03

Claims (5)

발효삼채를 유효성분으로 함유하는 숙취해소용 건강기능식품 조성물.The present invention relates to a health functional food composition useful as a hangover remedy comprising fermented trihydrate as an active ingredient. 제1항에 있어서, 상기 발효삼채는 혈중 알코올 탈수소효소(alcohol dehydrogenase) 및 알데하이드 탈수소효소(aldehyde dehydrogenase)의 함량을 증가시키는 것을 특징으로 하는 숙취해소용 건강기능식품 조성물.The health functional food composition according to claim 1, wherein the fermented trihydrate increases the content of alcohol dehydrogenase and aldehyde dehydrogenase in the blood. 제1항에 있어서, 상기 발효삼채는 유산균 및 과일 효소액을 포함하는 배지에 삼채 추출물의 건조분말을 첨가하여, 30~40℃에서 60~84 시간 동안 발효한 것을 특징으로 하는 숙취해소용 건강기능식품 조성물. The method according to claim 1, wherein the fermented syrup is fermented at 30 to 40 DEG C for 60 to 84 hours by adding dry powder of a pan extract to a medium containing lactic acid bacteria and fruit enzyme solution, Composition. 제3항에 있어서, 상기 유산균은 페디오코커스 애시디락티시(Pediococcus acidilactici), 락토바실러스 애씨도필러스(Lactobacillus acidophilus), 비피도박테리움 롱검(Bifidobacterium longum), 엔테로코커스 패시움(Enterococcus faecium) 및 스트렙토코커스 써모필러스(Streptococcus thermophilus) 중에서 선택된 하나 이상인 것을 특징으로 하는 숙취해소용 건강기능식품 조성물.4. The method according to claim 3, wherein the lactic acid bacterium is selected from the group consisting of Pediococcus acidilactici , Lactobacillus < RTI ID = 0.0 > acidophilus , Bifidobacterium longum), Enterococcus passive help (E nterococcus faecium) and Streptococcus Thermo filler's (Streptococcus thermophilus ). < / RTI > 제1항에 있어서, 상기 조성물은 분말, 과립, 환, 정제, 캡슐, 캔디, 시럽, 발포정 및 음료 중에서 선택된 어느 하나의 제형으로 제조되는 것을 특징으로 하는 숙취해소용 건강기능식품 조성물.The health functional food composition of claim 1, wherein the composition is prepared from any one of powder, granule, ring, tablet, capsule, candy, syrup, foamable beverage and beverage.
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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200138472A (en) 2019-05-29 2020-12-10 장대영 Composition for relieving hangover comprising allium hookeri extract and fish collagen

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20200138472A (en) 2019-05-29 2020-12-10 장대영 Composition for relieving hangover comprising allium hookeri extract and fish collagen

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