KR20180042912A - Microencapsulated mosquito repellent composition and method for preparing thereof - Google Patents

Abstract

The present invention relates to a microencapsulated mosquito repellent composition and to a manufacturing method thereof, and more particularly, to a microencapsulated mosquito repellent composition, which can be fixed to a fabric by adding a binder to a microcapsule containing a core material comprising a mosquito repellent component and a wall material containing a biodegradable polymer, an inorganic binder and a silane coupling agent, can avoid mosquitoes continuously by gradually emitting a mosquito repellent agent by external stimuli, and is safe and harmless to humans, and to a manufacturing method thereof.

Description

TECHNICAL FIELD The present invention relates to a microencapsulated mosquito repellent composition and a method for preparing the same,

The present invention relates to a microencapsulated mosquito repellent composition and a method for producing the same. More particularly, the present invention relates to a microencapsulated mosquito repellent composition and a method for producing the same. More particularly, To a microencapsulated mosquito repellent composition which is safe and harmless to the human body and a method for producing the same.

The habitat of mosquitoes is gradually expanding worldwide according to climate change. According to the World Health Organization, people who die from mosquito - borne diseases are increasing year by year, and WHO says 2 million people die every year out of the world 's 6 billion people due to global warming.

Mosquitoes not only attract people and livestock but also kill many people by mediating various diseases. Currently, about two-thirds of the world's population is exposed to mosquito-borne diseases.

There are more than 3,000 species of mosquitoes worldwide, and about 500 mosquito species, 300 mosquito species, and 350 malaria mosquitoes are distributed to humans.

Mosquitoes cause damage to people and livestock directly or indirectly. They are not only mediating diseases such as malaria, encephalitis, yellow fever and dengue fever, but also interfere with summer sleep disturbance and outdoor activities.

These mosquitoes are eager to survive in early heat due to the effects of warming. Japanese encephalitis, a mosquito-borne disease, causes headaches and vomiting when the virus spreads into the bloodstream and rises to high temperature (39-40 ° C) If you suffer from consciousness, convulsions, or coma, you will lose your life.

Mosquito is very sensitive to human smell of carbon dioxide, lactic acid, amino acid and ammonia because smell is very developed. Therefore, in order to develop a mosquito repellent agent, the technique of shielding the odor should be performed in parallel.

Korean Patent Publication No. 10-2014-0042008

In the present invention, microcapsules are prepared using a mosquito repellent as a core material, and the microcapsules are bonded to the fibers as a result of adding a binding agent to the microcapsules, thereby confirming that the mosquitoes can be continuously avoided. It was completed.

Accordingly, the present invention provides a microencapsulated mosquito-repellent composition capable of being fixed to fibers and gradually releasing a mosquito repellent agent by external stimuli to continuously avoid mosquitoes and being safe to humans and safe from skin rashes, and a method for manufacturing the same .

In order to achieve the above object, the present invention relates to a core material comprising a mosquito repellent component; A wall material comprising a biodegradable polymer, an inorganic binder and a silane coupling agent; And a binder. The microencapsulated mosquito repellent composition of the present invention comprises:

Also,

(S1) dissolving a mosquito repellent component in a dispersion solvent to prepare a mosquito repellent solution for a core material;

(S2) dissolving the biodegradable polymer in distilled water and stirring at 70 to 90 ° C for 1 to 2 hours to prepare a biodegradable polymer solution;

(S3) dissolving an inorganic binder and a silane coupling agent in distilled water and stirring at a temperature of 20 to 40 DEG C for 2 to 4 hours to prepare a hybrid silica solution;

(S4) adding a hybrid silica solution of (S3) to the biodegradable polymer solution of (S2) and stirring at a temperature of 50 to 60 ° C for 4 to 5 hours to prepare a hybrid organic / inorganic hybrid solution for a wall material;

(S5) The mosquito repellent solution of (S1) is added to the organic / inorganic hybrid solution of (S4), stirred at 40 to 50 ° C, stirred at room temperature for 2 to 3 hours, aged at room temperature for 20 to 30 hours Thereby preparing a microcapsule solution; And

(S6) preparing a microcapsule for mosquito-avoiding by adding a binder to the microcapsule solution of (S5);

The present invention provides a method for producing a microencapsulated mosquito repellent for screen printing which comprises:

According to the present invention, microcapsules are prepared using a mosquito repellent as a core material, and the microcapsules can be fixed to the fibers by adding a binding agent to the microcapsules. The mosquito repellent is gradually released by external stimuli, It is harmless to human body and is safe without skin rash.

1 is a view illustrating the structure of a microencapsulated mosquito repellent according to an embodiment of the present invention.

Hereinafter, the present invention will be described in detail.

1 is a view illustrating the structure of a microencapsulated mosquito repellent according to an embodiment of the present invention.

1, the microencapsulated mosquito repellent 10 according to the present invention comprises a core material 11 located inside a capsule, a wall material 13 coating an outer circumferential surface of the core material 11, And a binder (15) mixed in the wall material (13).

The core material 11 comprises a mosquito repellent component.

It is preferable to use a natural ingredient having a function of shielding the smell of carbon dioxide, lactic acid, amino acid, ammonia, etc., which is emitted by a person at the same time as the mosquito repellent function. For example, natural essential oils such as citronella oil, lemon grass oil, cinnamon leaf (cinnamon) oil and peppermint oil, sulfur water, tannin solution, ascorbic acid and the like can be used as the mosquito repellent agent.

The mosquito repellent may be used in an amount of 10 to 50 parts by weight based on 100 parts by weight of the core material. If the content is less than 10 parts by weight, the function of mosquito repellency and odor shielding may be insignificant. If the content exceeds 50 parts by weight, the effectiveness against the usage amount is inefficient.

The wall material 13 coating the outer circumferential surface of the core material is not harmful to the human body and it is preferable to use an environmentally friendly material. In addition, depending on the kind of the core material, the wall material should be appropriately controlled by the molecular structure and the glass transition temperature, and the material should be capable of controlling the release rate of the core material by the film structure. In addition, wall materials should not cause environmental pollution even after use.

Accordingly, in the present invention, a biodegradable polymer is used as a component of a wall material, and an inorganic binder and a silane coupling agent are included together to form an organic / inorganic hybrid with the biodegradable polymer.

Examples of the biodegradable polymer include gelatin, chitosan, pectin, starch, carrageenan, cellulose, alginate, textur, serum albumin, dextran sulfate, cellulose, chitin, agarose, amylose, proteoglycan, glycosaminoglycan, (PEG), poly (lactic-co-glycolic acid), dendrimer, PLLA (poly-L-lactide), PEI (polyethylenimine) Especially gelatin, chitosan, pectin, propyl starch, carrageenan, cellulose and the like.

The biodegradable polymer may be used in an amount of 1 to 50 parts by weight based on 100 parts by weight of the wall material. If the content is less than 1 part by weight, the biodegradation effect of the microencapsulated mosquito repellent of the present invention may be insignificant. If the content is more than 50 parts by weight, the encapsulation may not be performed in an excessively large amount.

Further, in order to make the wall material containing biodegradable polymer as a main component more rigid and dense, it is necessary to form an organic or inorganic hydrocarbon film. Accordingly, in the present invention, an inorganic binder and a silane coupling agent are used together with the biodegradable polymer to form a dense and firm film.

Examples of the inorganic binder include silica sol, alumina sol, tetraethoxysilane, tetramethoxysilane, tetrapropoxysilane, tetraisopropoxysilane, phenyltrimethoxysilane, and vinyltrimethoxysilane.

The inorganic binder may be used in an amount of 10 to 40 parts by weight based on 100 parts by weight of the wall material. If the content is less than 10 parts by weight, it may be difficult to form a dense and firm film. If the content is more than 40 parts by weight, it may be difficult to form an organic or inorganic hydrocarbon film due to an excessive amount.

The silane coupling agent plays a role of forming a well-defined organic network structure and providing a pore size to effectively form an organic hybrid membrane.

Examples of the silane coupling agent include vinyltriethoxysilane, 3-glycidoxypropyltrimethoxysilane, 3-aminopropyltriethoxysilane, and neopentyltriethoxysilane. The content of the silane coupling agent is 100 weight% May be used in an amount of 1 to 30 parts by weight.

The present invention also relates to a microencapsulated mosquito repellent 10 comprising a core material 11 located inside the capsule and a wall material 13 coating the outer periphery of the core material 11, And a binder (15).

The binder 15 is a component used to fix the microencapsulated mosquito repellent to the fiber. The binder 15 binds the microcapsule mosquito repellent to the fiber by adding a printing binder, and at the same time, . In addition, the microencapsulated mosquito repellent agent of the present invention fixed to the fibers can gradually and externally release the mosquito repellent component by external stimulation, thereby continuously exhibiting the maximum mosquito repellent effect.

Examples of the binder include water-soluble acryl, urethane, epoxy, vinyl acetate, melamine, and nylon.

The binder may be used in an amount of 10 to 70 parts by weight based on 100 parts by weight of the total amount of the microencapsulated mosquito repellent. When the content of the binder is within the above range, the microcapsules are fixed to the fibers without affecting the release of the mosquito repellent of the present invention .

The present invention also provides a method for producing a microencapsulated mosquito repellent as described above.

Specifically, the method for producing the microencapsulated mosquito repellent of the present invention includes the following steps.

(S1) dissolving a mosquito repellent component in a dispersion solvent to prepare a mosquito repellent solution for a core material;

(S2) dissolving the biodegradable polymer in distilled water and stirring at 70 to 90 ° C for 1 to 2 hours to prepare a biodegradable polymer solution;

(S3) dissolving an inorganic binder and a silane coupling agent in distilled water and stirring at a temperature of 20 to 40 DEG C for 2 to 4 hours to prepare a hybrid silica solution;

(S4) adding a hybrid silica solution of (S3) to the biodegradable polymer solution of (S2) and stirring at a temperature of 50 to 60 ° C for 4 to 5 hours to prepare a hybrid organic / inorganic hybrid solution for a wall material;

(S5) The mosquito repellent solution of (S1) is added to the organic / inorganic hybrid solution of (S4), stirred at 40 to 50 ° C, stirred at room temperature for 2 to 3 hours, aged at room temperature for 20 to 30 hours Thereby preparing a microcapsule solution; And

(S6) A step of preparing a microencapsulated mosquito repellent by adding a binder to the microcapsule solution of (S5).

Hereinafter, the manufacturing method of the present invention will be described in detail in each step.

(S1) for the production of mosquito repellent solution

The mosquito repellent solution is prepared by dissolving a mosquito repellent component as a core material in a dispersion solvent.

As the dispersion solvent, methyl alcohol, ethyl alcohol, propyl alcohol, butyl alcohol, isopropyl alcohol and the like can be used. The dispersion solvent may be used in an amount of 40 to 500 parts by weight based on 100 parts by weight of the core material.

Further, a conventional surfactant may be further added to the mosquito repellent solution if necessary.

(S2) < / RTI >

The biodegradable polymer solution is prepared by dissolving a biodegradable polymer in distilled water.

The distilled water is added at a ratio of 10 to 80 parts by volume relative to the biodegradable polymer and stirred at a temperature of 70 to 90 ° C, preferably 80 ° C for 1 to 2 hours to sufficiently dissolve the biodegradable polymer. At this time, the pH of the solution is preferably adjusted to 4 to 5, and 1 M hydrochloric acid may be added to adjust the pH.

(S3) hybrid silica solution preparation

The hybrid silica solution is prepared by dissolving an inorganic binder and a silane coupling agent in a dispersion solvent.

As the dispersion solvent, an organic solvent such as methyl alcohol, ethyl alcohol, propyl alcohol, butyl alcohol, isopropyl alcohol, or distilled water may be used.

The dispersion solvent is added in an amount of 5 to 50 parts by volume based on the weight of the inorganic binder and the silane coupling agent and is sufficiently dissolved by stirring at 20 to 40 ° C for 2 to 4 hours, preferably 30 ° C for 3 hours. At this time, the pH of the solution is preferably adjusted to 4 to 5, and 1 M hydrochloric acid may be added to adjust the pH.

(S4) of the organic-inorganic hybrid solution preparation

The organic / inorganic hybrid solution is prepared by mixing the biodegradable polymer solution of (S2) and the hybrid silica solution of (S3).

That is, while the hybrid silica solution of (S3) is added to the biodegradable polymer solution of (S2), the solution is stirred at a temperature of 50 to 60 ° C for 4 to 5 hours at a rate of 400 to 500 rpm, The pH is adjusted to 3-4.

(S5) microcapsule solution preparation

The microencapsulation of the present invention can be produced by in situ polymerization. Briefly, polyvinyl alcohol is dispersed in the production of a wall material, which is a water-based part, a mosquito repellent component of a core material as an oil-based part is dissolved in a solvent, and the mixture is stirred at 1000 to 1,500 rpm to produce microcapsules. Thereafter, a viscosity modifier, a wetting agent, and the like, which are conventionally used in the production of microcapsules, may be further added.

In this step, the microcapsule solution is prepared by in situ polymerization method in which the mosquito repellent solution of (S1) is added to the organic / inorganic hybrid solution of (S4) and stirred at a speed of 1000 to 1500 rpm. At this time, the solution is stirred at a temperature of 40 to 50 ° C., and further cooled to room temperature. The microcapsules are further stirred for 2 to 3 hours and then aged at room temperature for 20 to 30 hours, preferably 24 hours. The pH is adjusted to 9-10 by adding 1 M sodium carbonate to the solution.

(S6) microencapsulated mosquito repellent preparation

After the completion of the aging in step (S5), microcapsules are present in the lower part of the solution and liquid is present in the upper part. At this time, the upper liquid is removed by the decantation method, and the remaining microcapsules (microcapsules) and the binder solution are mixed to prepare a microencapsulated mosquito repellent.

The binder solution is obtained by mixing a binder component such as water-soluble acrylic, urethane, epoxy, vinyl acetate, melamine and nylon with a dispersion solvent. The organic solvent or distilled water described in (S3) Can be used.

The precipitate and the binder solution are preferably mixed at a volume ratio of 2: 5: 1, preferably 3: 1, and the mixture of the precipitate and the binder solution is mixed for 20 to 40 minutes, preferably 30 minutes Followed by stirring to prepare a microencapsulated mosquito repellent for screen printing.

The microencapsulated mosquito repellent for screen printing according to the present invention can be fixed to fibers by adding a binding agent to microcapsules and gradually releases mosquito repellent by external stimuli to continuously avoid mosquitoes It is harmless to the human body and is safe without skin rash.

Hereinafter, the present invention will be described in more detail with reference to examples. These embodiments are for purposes of illustration only and are not intended to limit the scope of protection of the present invention.

Example 1. Preparation of mosquito repellent solution for core material

2 g of citronella oil, 3 g of lemon grass oil, 3 g of cinnamon leaf (cinnamon) oil, 1 g of sulfur water and 1 g of tannin solution were added to ethyl alcohol and propyl alcohol (1: 1) And the mixture was stirred for 1 to 2 hours.

Example 2. Preparation of biodegradable polymer solution

5 g of gelatin and chitosan were dissolved in 250 g of distilled water, 3 g of polyvinyl alcohol (polymerization degree 1500) was added to the mixed solution, and the mixture was stirred at 80 ° C. for 1 to 2 hours to dissolve sufficiently. At this time, the pH of the solution was adjusted to 4 to 5 by adding 1 M hydrochloric acid to the solution.

Example 3. Preparation of Hybrid Silica Solution

1.7 g of tetraethoxysilane as an inorganic binder, 1.5 g of methyltrimethoxysilane and 0.7 g of 3-glycidoxypropyltrimethoxysilane as a silane coupling agent were added ethyl alcohol and distilled water as a solvent, and the mixture was stirred at 30 DEG C for 3 hours And dissolved by stirring. At this time, the pH of the solution was adjusted to 4 to 5 by adding 1 M hydrochloric acid to the solution.

Example 4. Preparation of organic hybrid solution

The hybrid silica solution prepared in Example 3 was added to the biodegradable polymer solution prepared in Example 2 and stirred at a temperature of 50 to 60 ° C. for 4 to 5 hours at a rate of 400 to 500 rpm. At this time, the pH of the solution was adjusted to 3 to 4 by adding 1 M hydrochloric acid to the solution.

Example 5. Preparation of microcapsule solution

The mosquito repellent solution prepared in Example 1 was slowly added to the organic or inorganic hybrid solution prepared in Example 4 and stirred at a speed of 1000-1500 rpm. At this time, 1M sodium carbonate solution was added to the solution to adjust the pH of the solution to 9-10. The solution was stirred at a temperature of about 40 to 50 ° C, and further stirred for 2 to 3 hours while being cooled to room temperature. And aged at room temperature for 24 hours.

Example 6. Preparation of microencapsulated mosquito repellent for screen printing

The binder solution (5 g of water-soluble acrylic resin dissolved in 250 g of distilled water) was added to the remaining precipitate (in the presence of microcapsules) at a volume ratio of 3: 1 And the mixture was stirred for 30 minutes to prepare a microencapsulated mosquito repellent for screen printing.

Comparative Example 1

The microcapsule mosquito repellent prepared by filtering the microcapsule solution prepared in Example 5 was used.

The microencapsulated mosquito repellent for screen printing and the microcapsule mosquito repellent for Comparative Example 1 prepared in Example 6 were fixed to fibers and the degree of fixation and the amount of mosquito repellent component released and sustained by external stimuli were measured .

As a result of the experiment, it was confirmed that the microencapsulated mosquito repellent for screen printing according to the present invention was able to be fixed to fibers, and the amount of mosquito repellent component released by stimulation was not only continuously released but also completely released It was confirmed that the sustained release was sustained by maintaining stimulation. On the other hand, in the case of the microcapsule mosquito repellent of Comparative Example 1 in which the flame-retardant binder was not added, the release of the mosquito repellent component was maintained at a certain level, but the flame-retardant component was not added to the fiber, The release was not done properly.

From the above results, it can be seen that when the microencapsulated mosquito repellent for screen printing according to the present invention is used, the mosquito repellent effect is excellent because it is fixed to the fiber and the proper amount of discharge is continuously maintained due to external stimulation.

Although the present invention has been described in terms of the preferred embodiments mentioned above, it is possible to make various modifications and variations without departing from the spirit and scope of the invention. It is also to be understood that the appended claims are intended to cover such modifications and changes as fall within the scope of the invention.

Claims (3)

A core material comprising a mosquito repellent component;
A wall material comprising a biodegradable polymer, an inorganic binder and a silane coupling agent; And
bookbinder;
≪ / RTI > mosquito repellent composition. The method according to claim 1,
Wherein the mosquito repellent is at least one selected from citronella oil, lemon grass oil, cinnamon leaf (cinnamon) oil, peppermint oil, sulfur water, tannin solution and ascorbic acid, and the biodegradable polymer is at least one selected from the group consisting of gelatin, , Carrageenan, cellulose, alginate, chitosan, textur, serum albumin, dextran sulfate, celluloses, chitin, agarose, amylose, proteoglycans, glycosaminoglycans, collagen, polylysine, pullulan, protamine, Wherein the inorganic binder is at least one selected from the group consisting of PEG, PLGA (poly (lactic-co-glycolic) acid), dendrimer, PLLA (poly- , Tetraethoxy silane, tetramethoxy silane, tetrapropoxy silane, tetraisopropoxy silane, phenyl trimethoxy silane, and vinyl trimethoxy silane , Wherein the silane coupling agent is at least one selected from vinyltriethoxysilane, 3-glycidoxypropyltrimethoxysilane, 3-aminopropyltriethoxysilane and urnyltriethoxysilane. ≪ / RTI > (S1) dissolving a mosquito repellent component in a dispersion solvent to prepare a mosquito repellent solution for a core material;
(S2) dissolving the biodegradable polymer in distilled water and stirring at 70 to 90 ° C for 1 to 2 hours to prepare a biodegradable polymer solution;
(S3) dissolving an inorganic binder and a silane coupling agent in a dispersion solvent and stirring at a temperature of 20 to 40 DEG C for 2 to 4 hours to prepare a hybrid silica solution;
(S4) adding a hybrid silica solution of (S3) to the biodegradable polymer solution of (S2) and stirring at a temperature of 50 to 60 ° C for 4 to 5 hours to prepare a hybrid organic / inorganic hybrid solution for a wall material;
(S5) The mosquito repellent solution of (S1) is added to the organic / inorganic hybrid solution of (S4), stirred at 40 to 50 ° C, stirred at room temperature for 2 to 3 hours, aged at room temperature for 20 to 30 hours Thereby preparing a microcapsule solution; And
(S6) preparing a microencapsulated mosquito repellent by adding a binder to the microcapsule solution of (S5);
≪ RTI ID = 0.0 > 1, < / RTI >

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