KR20180021435A - Composition for Hair Growth Stimulation or Hair Loss Prevention Using a Horse Oil Extract of Eclipta prostrata - Google Patents
Composition for Hair Growth Stimulation or Hair Loss Prevention Using a Horse Oil Extract of Eclipta prostrata Download PDFInfo
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- KR20180021435A KR20180021435A KR1020160105954A KR20160105954A KR20180021435A KR 20180021435 A KR20180021435 A KR 20180021435A KR 1020160105954 A KR1020160105954 A KR 1020160105954A KR 20160105954 A KR20160105954 A KR 20160105954A KR 20180021435 A KR20180021435 A KR 20180021435A
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- hair
- composition
- present
- food
- hair loss
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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Abstract
Description
본 발명은 한련초(Eclipta prostrata)의 마유에 의한 추출물을 이용한 발모 촉진 또는 탈모 억제용 조성물을 이용한 발모 촉진 또는 탈모 억제용 조성물에 관한 것이다.The present invention relates to an Eclipta The present invention relates to a composition for promoting hair growth or inhibiting hair loss,
모발은 모낭(hair follicles)에서 형성되는데 성인의 모낭은 약 5백만 개로 사람의 피부 중 손바닥과 바다박을 제외한 전신에 걸쳐 분포하여 있고, 두부에 1백만 개가 존재하며, 이 중 십만 개가 두피에 존재한다(Bulletin of Food Technology 2009, 22(4):651-663). 두피 모발은 인체 모발의 약 20%를 차지하는데, 땀의 증발과 체온 조절 등의 모발의 생리적 기능과 함께 두부의 완충작용으로 두부를 충격으로부터 보호하는 기능을 가지며, 외모를 중시하는 현대인의 경향에 의하여 개인의 개성과 이미지 연출에 중요한 사회적 기능을 아울러 가진다(Clin Dermatol 2001, 19(2):161-166).Hair is formed in hair follicles. Adult hair follicles are about 5 million, distributed throughout the body except the palms and seashells of human skin, and there are 1 million of them in the tofu, and 100,000 of them are present in the scalp (Bulletin of Food Technology 2009, 22 (4): 651-663). The scalp hair accounts for about 20% of the human hair. It has the physiological function of the hair such as the evaporation of the sweat and the control of the body temperature and the function of protecting the tofu from impact by the buffer function of the tofu. (Clin Dermatol 2001, 19 (2): 161-166). In addition, it is important to understand the social function of the individual.
개개의 모발은 모낭에 기원을 두어 성장하는데, 모낭은 매우 복잡한 기관으로 내모근초, 외모근초, 모간, 모기질세포 등으로 구성되며, 모낭을 형성하는 다양한 종류의 세포들 중 모유두세포(Hair dermal papilla cell)는 모발 성장에서 아주 중요한 역할을 한다.Hair follicles are composed of hair follicles, hair follicles, hair follicles, hair follicles, hair follicles, hair follicles, hair follicles, and hair follicles. papilla cell) plays a very important role in hair growth.
모구(Hair bulb) 내에서 특화된 섬유아세포(Dermal fibroblast)의 일종인 모유두세포(Dermal papilla cell)는 정상 모발 주기뿐만 아니라 남성형 탈모인 안드로겐(Androgen)성 탈모와 같은 증상에서 모유두세포의 증식을 통하여 모발 성장을 조절하는 중요한 역할을 하고 있다. 따라서 모발 탈락에서 모유두세포의 증식에 영향을 미치는 인자는 탈모를 개선시키기 위한 중요한 표적이 된다. Dermal papilla cells, a type of specialized dermal fibroblast within the hair bulb, have been shown to induce hair growth through the proliferation of papillary cells in conditions such as normal hair cycle as well as male androgenic alopecia, It plays an important role in regulating growth. Therefore, factors affecting proliferation of dermal papilla cells in hair loss are important targets for improving hair loss.
모발은 생장기, 퇴행기 및 휴지기의 성장 주기를 반복하는데, 성인의 경우 두피 모발의 생장기는 약 2 ∼ 6년, 퇴행기는 2~3주, 휴지기는 2~3개월이다. 정상적인 두피에서 90~95%는 생장기에 있고 1% 미만은 퇴화기에 있으며 5~10%는 휴지기에 있는데, 매일 100개 이상의 모발이 휴지기에 접어들고 같은 수의 모낭은 다시 생장기로 들어간다(N Engl J Med 1999, 341(13):964-973). 일반적으로 탈모증이라 함은 이러한 주기 중에서 성장기의 모발 비율이 짧아지고 퇴행기 또는 휴지기가 길어져 비정상적으로 모발이 탈락하는 숫자가 많아지는 것을 일컫는다(Differentiation, 2004, 72(9-10):489; Dev Cell., 2001, 1(1):13; J. Invest. Dermatol., 2005, 125(1):42).The hair repeats the growth cycle of the growth, regenerator and pausing period. For adults, scalp hair grows about 2 ~ 6 years, the regenerator is 2 ~ 3 weeks, and the rest period is 2 ~ 3 months. In normal scalp, 90 to 95% are in the growth phase, less than 1% are in the regenerator, and 5 to 10% are in the dormant period, with more than 100 hairs per day entering the dormant period and the same number of hair follicles entering the growth again (N Engl J Med 1999, 341 (13): 964-973). In general, alopecia refers to an increase in the number of abnormal hair loss due to the shortening of the hair growth rate in the growing period and the lengthening of the retrogressive or resting period in these cycles (Differentiation, 2004, 72 (9-10): 489; Dev Cell. , 2001, 1 (1): 13; J. Invest. Dermatol., 2005, 125 (1): 42).
발모 및 탈모의 정확한 기전은 현재까지 완전하게 밝혀져 있지 않으나, 탈모유발 원인으로 남성호르몬 관여에 의한 모포 기능의 저하, 모포 및 모구부의 신진대사기능의 저하, 두피 긴장에 의한 국소 혈류 장해, 영양 불량, 스트레스, 약물에 의한 부작용, 유전적 요인, 자가 면역, 국소감염, 화학물질, 백혈병, 결핵 등의 질병과 모발 제품의 남용 등 매우 다양하다. 탈모의 가장 전형적인 형태인 남성형 탈모증(androgen alopecia)의 경우 유전적으로 안드로겐(androgen) 호르몬에 의존적으로 발생하는데 포유류의 대표적인 안드로겐 호르몬에는 테스토스테론(testosterone)과 디하이드로테스토스테론(dihydrotestosterone)이 있는데 탈모 증상을 지니는 사람에게서 디하이드로테스토스테론이 생체내에서 높은 수준으로 유지되고 있음이 보고 되어 있고 디하이드로테스토스테론의 과다 생성이 탈모의 주요 원인으로 주목받고 있다(Biol. Pharm. Bull., 2006 29(2):392). 디하이드로테스토스테론은 제2형 5α-리덕타아제에 의해 테스토스테론이라는 남성 호르몬으로부터 생겨나는 또 다른 남성 호르몬이다.The precise mechanisms of hair growth and hair loss are not fully understood until now. However, the cause of hair loss is the decrease of hair follicle function due to the involvement of male hormone, the decrease of the metabolism function of hair follicle and parental part, the local blood flow obstruction due to scalp tension, Stress, drug side effects, genetic factors, autoimmunity, local infections, chemicals, leukemia, tuberculosis and abuse of hair products. The most typical form of hair loss, androgen alopecia, is genetically dependent on androgen hormones. The typical androgen hormones of mammals include testosterone and dihydrotestosterone, (Biol. Pharm. Bull., 2006, 29 (2): 392). It has been reported that dihydrotestosterone is maintained at high levels in vivo, and excessive production of dihydrotestosterone is attracting attention as a major cause of hair loss. Dihydrotestosterone is another male hormone that results from the male hormone testosterone by type 2 5α-reductase.
종래의 탈모증 치료방법으로는, 이러한 호르몬설과 관련하여 여성 호르몬을 주재로 한 제제가 있었으나 효과뿐 아니라 피부 염증 발생, 호르몬 투여에 의한 부작용 발생 등의 보고가 있어 현재는 사용이 중단되어 있다. 현재 탈모 치료에 가장 많이 사용되는 약물로는 제2형 5α-리덕타제의 활성을 억제시키는 물질로 미녹시딜(Minoxidil) 제제(미국특허 제4,139,619호 및 제4,596,812호 참조)과 피나스테라이드(finasteride)(미국 특허 제5547957호, 제5760046호 또는 대한민국 특허 제375083호)를 들 수 있다. 미녹시딜 제제는 탈모증이 있는 남성에게서 10%까지 탈모를 감소시키는 효과가 있다고 알려져 있지만 가마 부위 이외 부위의 탈모에 대해서는 그다지 좋은 효과를 발휘하지 못한다는 단점이 있고 또 우울증을 유발할 수 있으며, 피나스테라이드 역시 일부 환자들에 대해서는 성욕 감퇴, 발기 부전 등의 부작용을 나타낸다는 문제점이 있다. 이러한 이유에서 최근 부작용이 적은 천연물에서 발모 촉진 또는 탈모 억제 활성을 갖는 물질을 찾는 노력이 이루어지고 있다.As a conventional method of treating alopecia, there has been a preparation based on female hormone in relation to the hormone theory, but the use thereof has been discontinued due to reports of occurrence of skin inflammation and adverse effects due to administration of hormone. Currently, the most commonly used drugs for treating hair loss include Minoxidil preparations (see U.S. Patent Nos. 4,139,619 and 4,596,812) and finasteride (U.S. Patent Nos. 4,139,619 and 4,596,812) as inhibitors of the activity of type 2 5α- Japanese Patent No. 5547957, No. 5760046, or Korean Patent No. 375083). Although minoxidil is known to reduce hair loss by 10% in men with alopecia, it has a disadvantage in that it does not exert a very good effect on hair loss in areas other than the ovary and may cause depression, There is a problem that they exhibit side effects such as loss of libido and erectile dysfunction. For this reason, efforts have recently been made to find a substance having an activity of inhibiting hair growth or alopecia in a natural product having a low side effect.
본 발명은 한련초의 마유에 의한 추출물의 발모 촉진 활성 등을 개시한다. The present invention discloses the hair growth promoting activity of extracts of horse mackerel, and the like.
본 발명의 목적은 마유와 한련초 오일 혼합물을 이용한 발모 촉진 또는 탈모 억제용 조성물을 제공하는 데 있다.It is an object of the present invention to provide a composition for promoting hair growth or inhibiting hair loss using a mixture of MAU and HANSIKOCHO oil.
본 발명의 다른 목적이나 구체적인 목적은 이하에서 제시될 것이다. Other and further objects of the present invention will be described below.
본 발명은 아래의 실시예 및 실험예에서 확인되는 바와 같이, 저온 진공법으로 얻은 한련초의 마유에 의한 추출물이 사람 모유두세포와 사람 각질형성세포 증식을 촉진시킴을 확인함으로써 완성된 것이다.The present invention is accomplished by confirming that the extract obtained by the low-temperature vacuum method of horse mackerel obtained by the low-temperature vacuum method promotes human dermal papilla cells and human keratinocyte proliferation, as confirmed in the following examples and experimental examples.
본 발명은 이러한 실험 결과에 기초하여 제공되는 것으로, 본 발명의 발모 촉진 또는 탈모 억제용 조성물은 한련초의 마유에 의한 추출물을 유효성분으로 포함함을 특징으로 한다.The present invention is provided based on these experimental results, and the composition for promoting hair growth or depilation of hair according to the present invention is characterized by containing an extract of Mayuchosus byusa as an active ingredient.
본 명세서에서 "유효성분"이란 단독으로 목적하는 활성을 나타내거나 또는 그 자체는 활성이 없는 담체와 함께 활성을 나타낼 수 있는 성분을 의미한다.As used herein, the term " active ingredient "alone means an ingredient which exhibits the desired activity or which can exhibit activity together with a carrier which is itself inactive.
또 본 명세서에서, 상기 "탈모"란 그 발생의 직·간접적인 원인을 불문하고 당업계에서 탈모로서 분류되는 모든 증상을 포함하는 의미로서 이해되어야 한다. 구체적으로 혈액 순환 불량, 디하이드로테스토스테론의 과다 생성 등에 따른 피지 과잉 분비, 과산화물 또는 세균 등에 의한 두피 기능 저하, 노화, 유전적 요인, 스트레스, 이들의 복합적인 작용 등에 의한 탈모 증상을 모두 포함하는 의미이다.In the present specification, the term "hair loss" should be understood as including all the symptoms classified as hair loss in the art regardless of the cause, directly or indirectly, of the occurrence thereof. Specifically, it is meant to include all of hair loss symptoms caused by defective blood circulation, excess sebum due to excessive production of dihydrotestosterone, depression of the scalp caused by peroxides or bacteria, aging, genetic factors, stress, .
또 본 명세서에서, "한련초의 마유에 의한 추출물"은 추출 대상인 한련초를 추출 용매인 마유로 추출하여 얻어진 것을 말한다. 이때 추출 효율을 높이기 위하여 저온진공법을 사용하는 것이 바람직하다. In the present specification, the term "extract of horse mackerel " refers to a product obtained by extracting horse mackerel, which is the object to be extracted, with an extracting solvent such as horse oil. At this time, it is preferable to use a low temperature vacuum method in order to increase extraction efficiency.
본 발명의 조성물은 그 유효성분을 성상, 용도, 제형, 배합 목적 등에 따라 발모 촉진 활성, 탈모 방지 활성 등을 나타낼 수 있는 한 임의의 양(유효량)으로 포함할 수 있는데, 통상적인 유효량은 조성물 전체 중량을 기준으로 할 때 0.001 중량 % 내지 15 중량 % 범위 내에서 결정될 것이다. 구체적인 유효량은 당업자의 통상의 능력 범위 내에서 실험적으로 결정될 수 있다.The composition of the present invention may contain any amount (effective amount) of the active ingredient as long as it can exhibit hair growth promoting activity, hair loss preventing activity, etc. depending on the form, use, formulations, And will be determined within the range of 0.001 wt% to 15 wt% based on the weight. The specific effective amount can be determined experimentally within the ordinary skill of those skilled in the art.
본 발명의 조성물은 구체적인 양태에 있어서, 식품 조성물로서 파악할 수 있다.In a specific embodiment, the composition of the present invention can be identified as a food composition.
본 발명의 식품 조성물은 어떠한 형태로도 제조될 수 있으며, 예컨대 차, 쥬스, 탄산음료, 이온음료 등의 음료류, 우유, 요구루트 등의 가공 유류, 껌류, 떡, 한과, 빵, 과자, 면 등의 식품류, 정제, 캡슐, 환, 과립, 액상, 분말, 편상, 페이스트상, 시럽, 겔, 젤리, 바 등의 건강기능식품 제제류 등으로 제조될 수 있다. 또 본 발명의 식품 조성물은 법률상·기능상의 구분에 있어서 제조·유통 시점의 시행 법규에 부합하는 한 임의의 제품 구분을 띨 수 있다. 예컨대 건강기능식품에관한법률에 따른 건강기능식품이거나, 식품위생법의 식품공전(식약처 고시, 식품의 기준 및 규격)상 각 식품유형에 따른 과자류, 두류, 다류, 음료류, 특수용도식품 등일 수 있다.The food composition of the present invention can be prepared in any form and can be used in various forms such as beverages such as tea, juice, carbonated drink, ionic drink, processed milk such as milk and request route, gum, rice cake, Korean confectionery, Such as foods, tablets, capsules, rings, granules, liquids, powders, flakes, pastes, syrups, gels, jellies, bars and the like. In addition, the food composition of the present invention may be classified into any product category as long as it meets the laws and regulations on the time of manufacture and distribution in the legal and functional category. For example, it may be a health functional food according to the Act on Health Functional Foods, or a confectionery, bean curd, beverage, beverage, special-purpose food, etc. according to each food type in the Food Code (Food Standards, .
본 발명의 식품 조성물에는 그 유효성분 이외에 식품첨가물이 포함될 수 있다. 식품첨가물은 일반적으로 식품을 제조, 가공 또는 보존함에 있어 식품에 첨가되어 혼합되거나 침윤되는 물질로서 이해될 수 있는데, 식품과 함께 매일 그리고 장기간 복용되므로 그 안전성이 보장되어야 한다. 식품위생법에 따른 식품첨가물공전(식약처 고시, 식품첨가물 기준 및 규격)에는 안전성이 보장된 식품첨가물이 화학적 합성품, 천연 첨가물, 혼합 제제류로 구분하여 한정적으로 규정되어 있는데, 이러한 식품첨가물은 기능적 측면에 있어서는 감미제, 풍미제, 보존제, 유화제, 산미료, 점증제 등으로 구분될 수 있다. The food composition of the present invention may contain food additives in addition to the active ingredients thereof. Food additives are generally understood to be substances that are added to foods and mixed or infiltrated into food in the manufacture, processing or preservation of food, and their safety must be ensured since they are taken daily with food and for long periods. The Food Additive Ordinance according to the Food Sanitation Law (Food Additives Standards, Standards and Standards for Food Additives) is limited to the classification of safe food additives as chemical synthetic, natural additives and mixed preparations. Sweeteners, flavors, preservatives, emulsifiers, acidifiers, and thickeners.
감미제는 식품에 적당한 단맛을 부여하기 위하여 사용되는 것으로, 천연의 것이거나 합성된 것을 사용할 수 있다. 바람직하게는 천연 감미제를 사용하는 경우인데, 천연 감미제로서는 옥수수 시럽 고형물, 꿀, 수크로오스, 프룩토오스, 락토오스, 말토오스 등의 당 감미제를 들 수 있다. A sweetener is used to impart a sweet taste suitable for foods, and natural or synthetic sweeteners can be used. Preferably, natural sweeteners are used. Examples of natural sweeteners include sugar sweeteners such as corn syrup solids, honey, sucrose, fructose, lactose and maltose.
풍미제는 맛이나 향을 좋게 하기 위하여 사용될 수 있는데, 천연의 것과 합성된 것 모두 사용될 수 있다. 바람직하게는 천연의 것을 사용하는 경우이다. 천연의 것을 사용할 경우에 풍미 이외에 영양 강화의 목적도 병행할 수 있다. 천연 풍미제로서는 사과, 레몬, 감귤, 포도, 딸기, 복숭아 등에서 얻어진 것이거나 녹차잎, 둥굴레, 대잎, 계피, 국화 잎, 자스민 등에서 얻어진 것일 수 있다. 또 인삼(홍삼), 죽순, 알로에 베라, 은행 등에서 얻어진 것을 사용할 수 있다. 천연 풍미제는 액상의 농축액이나 고형상의 추출물일 수 있다. 경우에 따라서 합성 풍미제가 사용될 수 있는데, 합성 풍미제로서는 에스테르, 알콜, 알데하이드, 테르펜 등이 이용될 수 있다. Flavors may be used to enhance taste or flavor, both natural and synthetic. Preferably, a natural one is used. When using natural ones, the purpose of nutritional fortification can be performed in addition to the flavor. Examples of natural flavoring agents include those obtained from apples, lemons, citrus fruits, grapes, strawberries, peaches, and the like, or those obtained from green tea leaves, Asiatica, Daegu, Cinnamon, Chrysanthemum leaves and Jasmine. Also, those obtained from ginseng (red ginseng), bamboo shoots, aloe vera, banks and the like can be used. The natural flavoring agent may be a liquid concentrate or a solid form of extract. If desired, a synthetic flavor agent may be used. As the synthetic flavor agent, esters, alcohols, aldehydes, terpenes and the like may be used.
보존제로서는 소르브산칼슘, 소르브산나트륨, 소르브산칼륨, 벤조산칼슘, 벤조산나트륨, 벤조산칼륨, EDTA(에틸렌디아민테트라아세트산) 등이 사용될 수 있고, 또 유화제로서는 아카시아검, 카르복시메틸셀룰로스, 잔탄검, 펙틴 등이 사용될 수 있으며, 산미료로서는 연산, 말산, 푸마르산, 아디프산, 인산, 글루콘산, 타르타르산, 아스코르브산, 아세트산, 인산 등이 사용될 수 있다. 산미료는 맛을 증진시키는 목적 이외에 미생물의 증식을 억제할 목적으로 식품 조성물이 적정 산도로 되도록 첨가될 수 있다.As the preservative, calcium sorbate, sodium sorbate, potassium sorbate, calcium benzoate, sodium benzoate, potassium benzoate, EDTA (ethylenediaminetetraacetic acid) and the like can be used, and as the emulsifier, acacia gum, carboxymethyl cellulose, xanthan gum, pectin And acidulant, malic acid, fumaric acid, adipic acid, phosphoric acid, gluconic acid, tartaric acid, ascorbic acid, acetic acid, phosphoric acid and the like may be used as the acidulant. The acidulant may be added so that the food composition has a proper acidity for the purpose of inhibiting the growth of microorganisms other than the purpose of enhancing the taste.
점증제로서는 현탁화 구현제, 침강제, 겔형성제, 팽화제 등이 사용될 수 있다.Examples of the thickening agent include suspending agents, sedimentation agents, gel-forming agents, bulking agents and the like.
본 발명의 식품 조성물은 전술한 바의 식품첨가물 이외에, 기능성과 영양성을 보충, 보강할 목적으로 당업계에 공지되고 식품첨가물로서 안정성이 보장된 생리활성 물질이나 미네랄류를 포함할 수 있다.The food composition of the present invention may contain physiologically active substances or minerals which are known in the art and which are stable as a food additive in addition to the above-mentioned food additives in order to supplement and supplement functional and nutritional properties.
그러한 생리활성 물질로서는 녹차 등에 포함된 카테킨류, 비타민 B1, 비타민 C, 비타민 E, 비타민 B12 등의 비타민류, 토코페롤, 디벤조일티아민 등을 들 수 있으며, 미네랄류로서는 구연산칼슘 등의 칼슘 제제, 스테아린산마그네슘 등의 마그네슘 제제, 구연산철 등의 철 제제, 염화크롬, 요오드칼륨, 셀레늄, 게르마늄, 바나듐, 아연 등을 들 수 있다. Examples of such physiologically active substances include catechins contained in green tea and the like, vitamins such as vitamin B1, vitamin C, vitamin E and vitamin B12, tocopherol, dibenzoyl thiamine, etc. Examples of minerals include calcium preparations such as calcium citrate, magnesium stearate , Iron preparations such as iron citrate, chromium chloride, potassium iodide, selenium, germanium, vanadium, zinc and the like.
본 발명의 식품 조성물에는 전술한 바의 식품첨가물이 제품 유형에 따라 그 첨가 목적을 달성할 수 있는 적량으로 포함될 수 있다.The food composition of the present invention may contain an appropriate amount of the above-mentioned food additives according to the product type so as to achieve the purpose of addition thereof.
본 발명의 식품 조성물에 포함될 수 있는 기타의 식품첨가물과 관련하여서는 식품위생법에 따른 식품공전이나 식품첨가물 공전을 참조할 수 있다.With regard to other food additives that may be included in the food composition of the present invention, reference may be made to the Food Code or the Food Additive Code in accordance with the Food Sanitation Law.
본 발명의 조성물은 다른 구체적인 양태에 있어서는 약제학적 조성물로 파악될 수 있다.In another specific embodiment, the composition of the present invention can be identified as a pharmaceutical composition.
본 발명의 약제학적 조성물은 법률상·기능상의 구분에 있어서 제조·유통 시점의 관련 시행 법규에 부합하는 한 임의의 제품 구분을 띨 수 있다. 예컨대 약사법에 따른 의약외품 또는 의약품이거나 의약품일 경우 일반의약품 또는 전문의약품일 수 있다. The pharmaceutical composition of the present invention may be classified into any product category as long as it is in compliance with relevant laws and regulations at the time of manufacture and distribution in the legal and functional category. For example, if it is a quasi-drug or medicine in accordance with the Pharmaceutical Affairs Law or a drug, it may be a general medicine or a special medicine.
본 발명의 약제학적 조성물은 그 유효성분 이외에 약제학적으로 허용되는 담체를 포함하여 당업계에 공지된 통상의 방법으로 투여 경로에 따라 경구용 제형 또는 비경구용 제형으로 제조될 수 있다. 여기서 "약제학적으로 허용되는" 의미는 유효성분의 활성을 억제하지 않으면서 적용(처방) 대상이 적응 가능한 이상의 독성을 지니지 않는다는 의미이다.The pharmaceutical composition of the present invention may be prepared into oral formulations or parenteral formulations depending on the route of administration by conventional methods known in the art, including pharmaceutically acceptable carriers in addition to the active ingredients thereof. The term "pharmaceutically acceptable" as used herein means that the application (prescribing) subject does not have the above-mentioned toxicity that is adaptable without inhibiting the activity of the active ingredient.
본 발명의 약제학적 조성물이 경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 분말, 과립, 정제, 환제, 당의정제, 캡슐제, 액제, 겔제, 시럽제, 현탁액, 웨이퍼 등의 제형으로 제조될 수 있다. 이때 약제학적으로 허용되는 적합한 담체의 예로서는 락토스, 글루코스, 슈크로스, 덱스트로스, 솔비톨, 만니톨, 자일리톨 등의 당류, 옥수수 전분, 감자 전분, 밀 전분 등의 전분류, 셀룰로오스, 메틸셀룰로오스, 에틸셀룰로오스, 나트륨 카르복시메틸셀룰로오스, 하이드록시프로필메틸셀룰로오스 등의 셀룰로오스류, 폴리비닐 피롤리돈, 물, 메틸히드록시벤조에이트, 프로필히드록시벤조에이트, 마그네슘 스테아레이트, 광물유, 맥아, 젤라틴, 탈크, 폴리올, 식물성유 등을 들 수 있다. 제제화활 경우 필요에 따라 충진제, 증량제, 결합제, 습윤제, 붕해제, 계면활성제 등의 희석제 및/또는 부형제를 포함하여 제제화할 수 있다.When the pharmaceutical composition of the present invention is prepared into an oral formulation, it may be formulated into powder, granules, tablets, pills, sugar tablets, capsules, solutions, gels, syrups, suspensions, wafers And the like. Examples of suitable pharmaceutically acceptable carriers include sugars such as lactose, glucose, sucrose, dextrose, sorbitol, mannitol, xylitol, starch such as corn starch, potato starch and wheat starch, cellulose, methylcellulose, ethylcellulose, Cellulose derivatives such as sodium carboxymethyl cellulose and hydroxypropylmethyl cellulose, polyvinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, magnesium stearate, mineral oil, malt, gelatin, talc, And the like. In case of formulation, a diluent such as a filler, an extender, a binder, a wetting agent, a disintegrant, a surfactant, and / or an excipient may be formulated according to need.
본 발명의 약제학적 조성물이 비경구용 제형으로 제조될 경우, 적합한 담체와 함께 당업계에 공지된 방법에 따라 주사제, 경피 투여제, 비강 흡입제 및 좌제의 형태로 제제화될 수 있다. 주사제로 제제화할 경우 적합한 담체로서는 멸균수, 에탄올, 글리세롤이나 프로필렌 글리콜 등의 폴리올 또는 이들의 혼합물을 사용할 수 있으며, 바람직하게는 링거 용액, 트리에탄올 아민이 함유된 PBS(phosphate buffered saline)나 주사용 멸균수, 5% 덱스트로스 같은 등장 용액 등을 사용할 수 있다. 경피 투여제로 제제화할 경우 연고제, 크림제, 로션제, 겔제, 외용액제, 파스타제, 리니멘트제, 에어롤제 등의 형태로 제제화할 수 있다. 비강 흡입제의 경우 디클로로플루오로메탄, 트리클로로플루오로메탄, 디클로로테트라플루오로에탄, 이산화탄소 등의 적합한 추진제를 사용하여 에어로졸 스프레이 형태로 제제화할 수 있으며, 좌제로 제제화할 경우 그 기제로는 위텝솔(witepsol), 트윈(tween) 61, 폴리에틸렌글리콜류, 카카오지, 라우린지, 폴리옥시에틸렌 소르비탄 지방산 에스테르류, 폴리옥시에틸렌 스테아레이트류, 소르비탄 지방산 에스테르류 등을 사용할 수 있다.When the pharmaceutical composition of the present invention is prepared into a parenteral dosage form, it may be formulated in the form of an injection, transdermal drug delivery, nasal aspirate and suppository together with a suitable carrier according to methods known in the art. As the carrier suitable for injection preparation, sterilized water, ethanol, polyol such as glycerol or propylene glycol, or a mixture thereof, may be used, and preferably, a solution of Ringer's solution, phosphate buffered saline containing triethanolamine or sterilized by injection Water, or isotonic solution such as 5% dextrose may be used. When formulated with a transdermal preparation, it can be formulated in the form of ointments, creams, lotions, gels, external liquids, pastes, liniments, and air-lozenges. The nasal inhalant may be formulated in the form of an aerosol spray using a suitable propellant such as dichlorofluoromethane, trichlorofluoromethane, dichlorotetrafluoroethane, carbon dioxide, etc. When formulated as a suppository, witepsol, tween 61, polyethylene glycols, cacao butter, laurin, polyoxyethylene sorbitan fatty acid esters, polyoxyethylene stearates, and sorbitan fatty acid esters.
약제학적 조성물의 제제화와 관련하여서는 당업계에 공지되어 있으며, 구체적으로 문헌[Remington's Pharmaceutical Sciences(19th ed., 1995)] 등을 참조할 수 있다. 상기 문헌은 본 명세서의 일부로서 간주 된다.The formulation of pharmaceutical compositions is well known in the art and can be specifically described in Remington ' s Pharmaceutical Sciences (19th ed., 1995). This document is considered part of this specification.
본 발명의 약제학적 조성물의 바람직한 투여량은 환자의 상태, 체중, 성별, 연령, 환자의 중증도, 투여 경로에 따라 1일 0.001mg/kg ~ 10g/kg 범위, 바람직하게는 0.001mg/kg ~ 1g/kg 범위일 수 있다. 투여는 1일 1회 또는 수회로 나누어 이루어질 수 있다. 이러한 투여량은 어떠한 측면으로든 본 발명의 범위를 제한하는 것으로 해석되어서는 아니 된다. The preferred dosage of the pharmaceutical composition of the present invention is 0.001 mg / kg to 10 g / kg per day, preferably 0.001 mg / kg to 1 g / day, depending on the patient's condition, body weight, sex, age, / kg < / RTI > The administration can be carried out once or several times a day. Such dosages should in no way be construed as limiting the scope of the invention.
본 발명의 조성물은 또 다른 구체적인 양태에 있어서, 모발 또는 두피에 외용적으로 적용하기 위한 모발 화장료 조성물로 파악할 수 있다.In another specific embodiment, the composition of the present invention can be identified as a hair cosmetic composition for external application to hair or scalp.
본 발명의 조성물이 모발 화장료 조성물로 파악될 경우에도 그 모발 화장료 조성물은 용액, 현탁액, 유탁액, 페이스트, 젤, 크림, 로션, 파우더, 샴푸, 비누, 계면활성제-함유 클렌징, 오일, 분말 파운데이션, 유탁액 파운데이션, 왁스 파운데이션, 스프레이 등의 제품 형태를 띨 수 있다. 구체적인 제품 형태에 있어서는 유연 화장수, 영양 화장수, 영양 크림, 마사지 크림, 에센스, 아이 크림, 클렌징 크림, 클렌징 포옴, 클렌징 워터, 팩, 스프레이 또는 파우더의 제형 등일 수 있다.Even when the composition of the present invention is recognized as a hair cosmetic composition, the hair cosmetic composition may be in the form of a solution, suspension, emulsion, paste, gel, cream, lotion, powder, shampoo, soap, surfactant-containing cleansing oil, Emulsion foundation, wax foundation, spray, and the like. In a specific product form, it may be a form of flexible lotion, nutritional lotion, nutritional cream, massage cream, essence, eye cream, cleansing cream, cleansing foam, cleansing water, pack, spray or powder.
본 발명의 화장료 조성물은 그 유효성분 이외에 화장료 조성물에 통상적으로 이용되는 성분들, 예컨대, 안정화제, 용해화제, 계면활성제, 비타민, 색소 및 항료와 같은 통상적인 보조제, 및 담체를 포함할 수 있다. The cosmetic composition of the present invention may contain, in addition to its active ingredient, conventional additives such as stabilizers, solubilizing agents, surfactants, vitamins, colorants and antioxidants, and carriers commonly used in cosmetic compositions.
본 발명의 제형이 페이스트, 크림 또는 젤인 경우에는 담체 성분으로서 동물성유, 식물성유, 왁스, 파라핀, 전분, 트라칸트, 셀룰로오스 유도체, 폴리에틸렌 글리콜, 실리콘, 벤토나이트, 실리카, 탈크 또는 산화아연 등이 이용될 수 있다.When the formulation of the present invention is a paste, a cream or a gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as a carrier component .
본 발명의 제형이 파우더 또는 스프레이인 경우에는 담체 성분으로서 락토스, 탈크, 실리카, 알루미늄 히드록시드, 칼슘 실리케이트 또는 폴리아미드 파우더가 이용될 수 있고, 특히 스프레이인 경우에는 추가적으로 클로로플루오로히드로카본, 프로판/부탄 또는 디메틸 에테르와 같은 추진체를 포함할 수 있다.When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.
본 발명의 제형이 용액 또는 유탁액인 경우에는 담체 성분으로서 용매, 용해화제 또는 유탁화제가 이용되는데, 구체적으로 물, 에탄올, 이소프로판올, 에틸 카보네이트, 에틸 아세테이트, 벤질 알코올, 벤질 벤조에이트, 프로필렌 글리콜, 1,3-부틸글리콜 오일, 글리세롤 지방족 에스테르, 폴리에틸렌 글리콜, 소르비탄의 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is a solution or emulsion, a solvent, a solubilizing agent or an emulsifying agent is used as a carrier component. Specifically, water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, 1,3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol, fatty acid esters of sorbitan, and the like.
본 발명의 제형이 현탁액인 경우에는 담체 성분으로서 물, 에탄올 또는 프로필렌 글리콜과 같은 액상의 희석제, 에톡실화 이소스테아릴 알코올, 폴리옥시에틸렌 소르비톨 에스테르, 폴리옥시에틸렌 소르비탄 에스테르와 같은 현탁제, 미소결정성 셀룰로오스, 알루미늄 메타히드록시드, 벤토나이트, 아가 등이 이용될 수 있다.When the formulation of the present invention is a suspension, a carrier, such as water, a liquid diluent such as ethanol or propylene glycol, a suspension such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester, polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar, etc. may be used.
본 발명의 제형이 계면-활성제 함유 클렌징인 경우에는 담체 성분으로서 지방족 알코올 설페이트, 지방족 알코올 에테르 설페이트, 설포숙신산 모노에스테르, 이세티오네이트, 이미다졸리늄 유도체, 메틸타우레이트, 사르코시네이트, 지방산 아미드 에테르 설페이트, 알킬아미도베타인, 지방족 알코올, 지방산 글리세리드, 지방산 디에탄올아미드, 식물성 유, 라놀린 유도체 또는 에톡실화 글리세롤 지방산 에스테르 등이 이용될 수 있다.When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component is selected from aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.
본 발명의 모발 화장료 조성물은 그 유효성분을 포함하는 것을 제외하고는 당업계에 통상적으로 행하여지는 화장료 조성물의 제조방법에 따라 제조할 수 있다.The hair cosmetic composition of the present invention can be produced by a method for producing a cosmetic composition which is usually carried out in the art, except that it contains the active ingredient.
전술한 바와 같이, 본 발명에 따르면 한련초의 마유에 의한 추출물을 이용한 발모 촉진 또는 탈모 억제용 조성물을 제공할 수 있다.As described above, according to the present invention, it is possible to provide a composition for promoting hair growth or inhibiting hair loss using an extract of Mayuchisiawis oryzae.
본 발명의 조성물은 식품, 약품, 모발 화장품 등으로 제품화될 수 있다.The composition of the present invention can be commercialized as foods, medicines, hair cosmetics and the like.
이하 본 발명을 실시예 및 실험예를 참조하여 설명한다. 그러나 본 발명의 범위가 이러한 실시예 및 실험예에 한정되는 것은 아니다.Hereinafter, the present invention will be described with reference to Examples and Experimental Examples. However, the scope of the present invention is not limited to these examples and experimental examples.
<< 실시예Example > > 시료의 준비Preparation of sample
한련초(Eclipta prostrata) 전초 건조 분말에 5배 중량의 제주산 마유를 첨가하고 저온 진공 건조기를 이용하여 40℃에서 40torr의 압력으로 12시간 추출하여 시료를 준비하였다. Eclipta prostrata ) 5 times as much weight of Jeju Acid as a pre-dried powder was prepared and extracted with a low-temperature vacuum dryer at 40 ° C under a pressure of 40 torr for 12 hours to prepare a sample.
<< 실험예Experimental Example > > 발모 촉진 또는 탈모 억제 효과 실험 Experiments to inhibit hair growth or alopecia suppression
<< 실험예Experimental Example 1> 1> 사람 Person 모유두세포Dermal papilla cells 증식 효과 평가 Evaluation of proliferation effect
상기 실시예의 시료가 사람 모유두세포(human hair dermal papilla cell)의 세포 증식에 미치는 효과를 아래와 같이 사람 모유두세포(human hair dermal papilla cell, HHDPC)(Sciencell사, cat. no. 2400)을 사용하여 평가하였다.The effect of the sample of the above example on the cell proliferation of human hair dermal papilla cells was evaluated using a human hair dermal papilla cell (HHDPC) (Sciencell, cat. No. 2400) Respectively.
10% FBS (fetal bovine serum, Cambrex)가 포함된 전용배지인 MSC(Mesenchymal Stem Cell) 배지에 사람 모유두세포(Sciencell사, cat. no. 2400)를 0.5 × 104 cells/이 되도록 하여 96 웰 플레이트에 접종하여 24 시간 동안, 37℃, 5% CO2 습윤 조건 하에서 배양하였다. 상기 배양액에 상기 실시예의 시료를 10 ㎍/ml의 농도로 처리하여 72 시간 동안 배양한 후, 5 mg/의 MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) 시약 20㎕를 상기 배양액에 넣고 37℃, 5% CO2 습윤 조건하에서 4시간 동안 배양하였다. 배양 시, 살아있는 세포에는 보라색의 크리스탈이 형성된다. 4시간 배양 후 배지를 제거하고 DMSO 100를 넣어 10분 동안 쉐이킹 인큐베이터(shaking incubator)에서 크리스탈을 녹인 후 570 nm에서 흡광도를 측정하여 세포 성장 정도를 측정하였다.From the dermal papilla in 10% FBS (Mesenchymal Stem Cell) dedicated medium containing (fetal bovine serum, Cambrex) MSC medium cell (Sciencell Co., cat. No. 2400) a 96-well plate to ensure that a 0.5 × 10 4 cells / And cultured for 24 hours at 37 DEG C under 5% CO 2 wet condition. After the sample was treated at a concentration of 10 μg / ml for 72 hours, 5 mg / MTT of 3- (4,5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide reagent was added to the above culture medium and cultured at 37 ° C under 5% CO 2 wet condition for 4 hours. In culture, purple crystals form in living cells. After 4 hours of incubation, the medium was removed, DMSO 100 was added, the crystal was dissolved in a shaking incubator for 10 minutes, and the absorbance was measured at 570 nm to measure the degree of cell growth.
결과를 대조군인 무처리군 대비 백분율로 아래 표 1에 나타내었다. The results are shown in Table 1 below as a percentage of the control group as the non-treated group.
상기 표 1의 결과는 상기 실시예의 시료가 모유두세포의 증식을 촉진함을 보여준다. The results in Table 1 show that the sample of the above example promotes the proliferation of the dermal papilla cells.
<< 실험예Experimental Example 2> 2> 사람 각질형성세포(Human keratinocytes ( HaCaTHaCaT cell) 증식 효과 평가 cell proliferation
상기 실시예의 시료가 사람 각질형성세포의 세포 성장에 미치는 효과를, 각질형성세포(HaCaT cell)(Dr. N. E. Fusenig (Heidelberg, Germany)을 사용하여, 상기 실험예 1과 동일한 방법으로 평가하였다. 배지는 10% FBS (fetal bovine serum, Cambrex)가 포함된 RPMI 배지를 사용하였다. The effect of the sample of the above example on the cell growth of human keratinocytes was evaluated in the same manner as in Experimental Example 1 using keratinocytes (HaCaT cell) (Dr. NE Fusenig (Heidelberg, Germany) Were cultured in RPMI medium supplemented with 10% FBS (fetal bovine serum, Cambrex ).
결과를 대조군인 무처리군 대비 백분율로 아래 표 2에 나타내었다. The results are shown in Table 2 below as a percentage of the control group.
상기 표 2의 결과는 상기 실시예의 시료가 사람각질형성세포의 증식을 촉진함을 보여준다. The results in Table 2 show that the sample of the above example promotes the proliferation of human keratinocytes.
Claims (4)
A composition for promoting hair growth or inhibiting hair loss, which comprises an extract of Mayuchisanthus as an active ingredient.
상기 조성물은 식품 조성물인 것을 특징으로 하는 발모 촉진 또는 탈모 억제용 조성물.
The method according to claim 1,
Wherein the composition is a food composition.
상기 조성물은 약제학적 조성물인 것을 특징으로 하는 발모 촉진 또는 탈모 억제용 조성물.
The method according to claim 1,
Wherein the composition is a pharmaceutical composition.
상기 조성물은 모발 화장료 조성물인 것을 특징으로 하는 발모 촉진 또는 탈모 억제용 조성물.
The method according to claim 1,
Wherein the composition is a hair cosmetic composition.
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