KR20180014551A - Cosmetic composition for increasing the efficacy of hair removal device based on photothermolysis - Google Patents

Abstract

In the present invention, a hair removal composition containing a photosensitizing component is used together with a hair removal device using light for removing hair, and thereby the biodegradation effect due to the photosensitizing component is added together with the pyrolysis effect due to light energy, and a high hair removal effect can be secured at a relatively low light intensity.

Description

TECHNICAL FIELD The present invention relates to a cosmetic composition for increasing the effectiveness of a hair-

The present invention relates to a cosmetic composition for enhancing the effect of a light-based hair removal device.

Hair is a generic term for hairs and hair, which develops from the skin and develops as a skin appendage. The hair repeats the anagen, ctagen, and talogens and has a cycle of growth, elimination, and initiation.

Hair is essentially an organ that has been functioning to protect the body but is degenerating with evolution. Human beings are covered with fur all but palms, soles, lips, and hairs, and the number is between 120 and 1.5 million. The hair is divided into hardness and softness by hardness. The moxa is black and hard with hair, eyebrow hair, eyelash hair, etc. The soft hair is soft and soft hair. In recent years, not only the coarse hairs on the side such as the armpit and the leg but also the hair on the whole body such as the human hair for the purpose of beauty are increasing.

Existing hair removal methods can be divided into physical hair removing method (eg razor), chemically hair removing method (eg hair removal cream), waxing or tweezers to remove roots, or laser Have been used. These methods have the disadvantage that they cause irritation to the skin when used over a long period of time, as well as roughness of the skin, contact dermatitis and pigmentation, and the use thereof is limited for wound areas and some parts such as the face.

In general, cosmetics for depilation use wax stripping (inducing decolorization after adhering to body hair) or protein melting type hair removal cream (a product mainly composed of a substance which dissolves keratin which is a hair protein).

Such hair cosmetic compositions are mainly used to reduce pain caused by hair removal, and they are used as an anesthetic cream before depilation treatment, a soothing cream that reduces the temperature of the skin and reduces inflammation after depilation, There is no such composition.

1. Korean Patent Publication No. 10-2012-0041042

It is an object of the present invention to provide a composition for hair removal that can achieve a high hair removal effect while minimizing light intensity when depilating hair using an optical hair removal device.

In the present invention, it is also possible to use derivatives such as indocyanine green (ICG), methylene blue, toluidine blue, aminolevulinic acid (ALA), phthalocyanine, porphyrin, texapyrine, bacterioclorine, merocyanine, psoralen, benzoporphyrin derivatives (BPD) And one or more photosensitizing substances selected from the group consisting of sodium chloride, sodium chloride, sodium chloride, sodium chloride, sodium chloride, and phimeric sodium.

In the present invention, it is also possible to use derivatives such as indocyanine green (ICG), methylene blue, toluidine blue, aminolevulinic acid (ALA), phthalocyanine, porphyrin, texapyrine, bacterioclomer, merocyanine, psoralen, benzoporphyrin derivatives (BPD) And at least one photosensitive material selected from the group consisting of sodium formate,

The present invention provides a hair removal method using a light-based hair removal device.

In the present invention, when a hair removal device using an optical device is used, a hair removal composition containing a photosensitive component is used together for a hair removal, so that a biodegradation effect due to a photosensitive component is added together with a pyrolysis effect due to light energy, A depilating effect can be ensured.

FIG. 1 is a graph showing the results of measurement of epilating effects after hair removal.

The present invention relates to a pharmaceutical composition comprising indocyanine green (ICG), methylene blue, toluidine blue, aminolevulinic acid (ALA), phthalocyanine, porphyrin, texaphyrin, bacterioclomer, merocyanin, psoralen, benzoporphyrin derivatives (BPD) And at least one photosensitive material selected from the group consisting of sodium chloride, sodium chloride, sodium chloride, and sodium phimeric.

Hereinafter, the hair removal composition according to the present invention will be described in more detail.

In the present invention, hair removal means removing hair. The distribution of the hairs is not particularly limited. However, for the purpose of the present invention, the hairs that are distributed in the body parts that are harmful to the beauty by incidence, growth or excessive distribution of hairs such as armpits, arms, It can mean.

The composition for hair removal according to the present invention comprises a photosensitive material.

The photosensitive material may be represented by a photosensitizer or an optical sensitizer. Generally, the photosensitizing substance reacts sensitively with oxygen and light in the body, and generates chemical reaction by light to generate active oxygen. The reactive oxygen selectively attacks specific lesions or specific cells to give therapeutic effect can do. The treatment using this photosensitive material is called photodynamic therapy.

In the present invention, a photosensitive material applied to photodynamic therapy is applied to a composition for hair removal.

The photosensitizer in the hair removal composition is activated by light to attack the hair follicle cells that produce and maintain hair. This biological effect can improve the hair removal effect.

The photosensitive material may be a photosensitive material used in the art without limitation. In the present invention, it is possible to use as a photosensitive material an indocyanine green (ICG), a methylene blue, a toluidine blue, an aminolevulinic acid (ALA), a phthalocyanine, a porphyrin, a texaphyrin, a bacterioclorin, a merocyanine, a psoralen, BPD) and sodium formaldehyde can be used.

In addition, the content of the photosensitive material may be 0.001 to 50% by weight, 0.01 to 30% by weight or 0.05 to 20% by weight based on 100% by weight of the composition for hair removal. If the amount is less than 0.001 parts by weight, the hair removal effect is insignificant. If the amount is more than 50 parts by weight, the increase in the effect of the material is insignificant, and it is difficult to secure the shape stability.

The hair removal composition according to the present invention may further comprise an anesthetic ingredient and a skin sedative in addition to the above-described photo sensitive ingredients.

The kind of the anesthetic ingredient and the skin sedative are not particularly limited as long as they do not absorb light having a light absorption wavelength range of the photosensitive material. Anesthetic ingredients may include, for example, one or more selected from the group consisting of procaine hydrochloride, lidocaine and its salts, benzocaine and its salts, and novacaine and its salts.

The skin calming agent may be at least one selected from the group consisting of sodium bicarbonate (baking soda), and a coal tar base material.

The composition for hair removal in accordance with the present invention may contain various additives such as antibacterial agents, preservatives, buffers, antioxidants, suspending agents, dispersing agents, emulsifying agents, quenching agents, chelating agents, lubricants, wetting agents, Sweeteners, or flavoring agents.

Examples of the antimicrobial agent or preservative include alkyl esters of p-hydroxybenzoic acid, hydantoin derivatives, propionate salts, phenol, cresol, mercury, phenyloxyethanol, benzyl alcohol, chlorobutanol, methyl and propyl p- At least one selected from the group consisting of thimerosal, benzalkonium chloride (e.g. benzethonium chloride), butyl-, methyl- and propyl-paraben, sorbic acid, and any of the various quaternary ammonium compounds And buffers can be selected from the group consisting of phosphate, glutamate, and citrate. Antioxidants include at least one selected from the group consisting of ascorbate, bisulfite, and sodium metabisulfite. Can be used. As the suspending agent and dispersing agent, at least one selected from the group consisting of sodium carboxymethyl cellulose (CMC), hydroxypropylmethyl cellulose (HPMC), polyvinyl alcohol (PVA) and polyvinylpyrrolidone (PVP) , And the emulsifying agent may be at least one selected from the group consisting of polyoxyethylene sorbitan monolaurate, polyoxyethylene sorbitan monooleate 80 and triethanolamine oleate, and EDTA as the quencher or chelating agent Can be used. In addition, as the pH adjuster, at least one selected from the group consisting of sodium hydroxide, hydrochloric acid, citric acid and lactic acid can be used.

In addition, the composition for hair removal according to the present invention may comprise a pharmaceutically acceptable carrier. In the present invention, the term "pharmaceutically acceptable carrier" refers to a carrier or diluent which does not disturb the biological activity and properties of the compound without stimulating the organism, and the composition may be formulated together with the carrier.

Such pharmaceutically acceptable carriers include but are not limited to lactose, dextrose, sucrose, sorbitol, mannitol, starch, acacia gum, calcium phosphate, alginate, gelatin, calcium silicate, microcrystalline cellulose, polyvinylpyrrolidone, , Syrups, methylcellulose, methylhydroxybenzoate, propylhydroxybenzoate, talc, magnesium stearate, and mineral oil.

The composition for hair removal in accordance with the present invention may be administered through any conventional route as long as it can reach the target tissue. Preferably, transdermal administration can be carried out, and local application is most preferable.

The hair removal composition according to the present invention can be used as a pharmaceutical composition, a cosmetic composition, or an external preparation for skin.

The appropriate dosage of the pharmaceutical composition of the present invention may be variously prescribed depending on factors such as the formulation method, administration method, age, body weight, sex, pathological condition, route of administration and the like of the patient. The dosage of the pharmaceutical composition of the present invention is preferably 0.001 to 1000 mg / kg (body weight) per day on an adult basis. In addition, it may be administered once or several times a day at a predetermined time interval.

The pharmaceutical composition according to the present invention may be a solid preparation, a semi-solid preparation, or a liquid preparation. Solid form preparations may include, but are not limited to, excipients, flavoring agents, binders, preservatives, disintegrants, lubricants, fillers, and the like. Examples of the semi-solid preparation include a cream, a lotion, an emulsifier, a liniment, and the like, but the present invention is not limited thereto, and can be produced by adding a suitable colorant, a flavoring agent, a stabilizer, a tackifier, a surfactant, and the like. Examples of the liquid preparation include water, alcohols, solutions such as solutions of propylene glycol, suspensions, emulsions and the like, but not limited thereto, and they can be prepared by adding appropriate coloring agents, flavoring agents, stabilizers, tackifiers and the like.

For example, powders can be prepared by simply mixing the active ingredient of the present invention with a suitable pharmaceutically acceptable carrier such as lactose, starch, microcrystalline cellulose and the like. The granules may contain the active ingredient of the present invention; A suitable pharmaceutically acceptable excipient; And a suitable pharmaceutically acceptable binder such as polyvinylpyrrolidone or hydroxypropylcellulose, followed by wet granulation using a solvent such as water, ethanol or isopropanol or dry granulation using a compressive force . Further, the tablet may be prepared by mixing the above granule with a suitable pharmaceutically acceptable salt such as magnesium stearate and then tableting it using a tablet machine.

When the composition for hair removal of the present invention is used in cosmetics, the cosmetics may be prepared in the form of a general emulsified formulation or a solubilized formulation. Lotion such as soft lotion or nutrition lotion; Lotion such as facial lotion or body lotion; Creams such as nutritional creams, moisture creams or eye creams; Body essence; Makeup ointment; spray; Gel; And the like.

The cosmetic may further contain at least one selected from the group consisting of a fatty substance, an organic solvent, a solubilizer, a thickener, a gelling agent, a softener, an antioxidant, a suspending agent, a stabilizer, a foaming agent, a fragrance, a surfactant, water, It contains adjuvants commonly used in cosmetics such as ionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic active agents, lipophilic active agents or lipid vesicles can do.

In addition, when the composition is used for an external preparation for skin, it may further contain at least one selected from the group consisting of fatty substances, organic solvents, solubilizers, thickening and gelling agents, softening agents, antioxidants, suspending agents, stabilizing agents, foaming agents, It is usually used in external skin preparations such as emulsifiers, nonionic emulsifiers, fillers, sequestering agents, chelating agents, preservatives, vitamins, blocking agents, wetting agents, essential oils, dyes, pigments, hydrophilic active agents, lipophilic active agents or lipid vesicles ≪ / RTI > any other ingredients that are commonly used in the skin sciences. The components can also be introduced in amounts commonly used in the field of dermatology.

When the external preparation for skin is provided, it may be prepared in any formulations conventionally produced in the art, except for formulations which do not interfere with light transmission, and examples thereof include creams, lotions, ointments, Mist, spray, and the like.

The frequency and amount of the composition according to the present invention can be widely varied depending on a hair growth rate of an individual, and can be prescribed in parallel with a surgical method such as a laser.

The composition for hair removal according to the present invention can be used together with a light-based hair removal device. The light-based epilator may be an intense pulse light (IPL) epilator or a laser epilator.

The present invention also relates to the use of indomethacin (ICG), methylene blue, toluidine blue, aminolevulinic acid (ALA), phthalocyanine, porphyrin, texapyrine, bacterioclomer, merocyanine, psoralen, benzoporphyrin derivatives (BPD) And at least one photosensitive material selected from the group consisting of sodium formate, sodium formate, and formaldehyde is applied to the skin and then epilated using the light-based epilator.

In general, when using a light-based hair removal device, there are many limitations such as that the hair removal effect is insignificant when the light intensity is lowered for safety, and the risk of the side effect is increased when the light intensity is increased. Therefore, a technique for securing the hair removal effect while minimizing the light intensity is required.

As described in the present invention, when a hair removal composition containing a photosensitive material is applied to skin and then a light-based hair removal device is used, the photosensitive material in the composition reacts with light generated from the hair removal device to generate active oxygen , The active oxygen attacks the hair follicle cells that produce and maintain hair. Therefore, the photodegradation effect by the optical-based manufacturing equipment and the biological effect by the photosensitive material are added, and a high hair removal effect can be obtained even at a relatively low light intensity.

At this time, hair removal can be performed at a wavelength of 400 to 1500 nm at an intensity of 1 to 30 J / cm ² for 0.001 to 100 seconds.

In one embodiment, when epilating using an Intense Pulsed Light (IPL) epilator, epilation using a xenon lamp having a continuous wavelength of 400 to 1200 nm can be used. When epilating using a laser epilation device, The selected single wavelength can be used to epilate.

Hereinafter, embodiments of the present invention will be described in detail to facilitate understanding of the present invention. However, the embodiments according to the present invention can be modified into various other forms, and the scope of the present invention should not be construed as being limited to the following embodiments. Embodiments of the invention are provided to more fully describe the present invention to those skilled in the art.

Example

Example  1 to 4 and Comparative Example  1 to 2

A composition for hair removal having a photoreactive substance (weight%) shown in Table 1 below was prepared.

Example 1 contained ICG as a photosensitive material and contained 16.15% by weight of glycerin, glycerin-26, cetearyl alcohol, tromethamine and 1,2-hexanediol, .

In Examples 2 to 4, the composition was prepared so as to have the same components and contents (preservative, antioxidant, and surfactant) as in Example 1, in addition to the photosensitive material.

division Photosensitive material Kinds Content (% by weight) Comparative Example 1 Not used - Comparative Example 2 Not used - Example 1 ICG 0.05 Example 2 ICG 0.1 Example 3 ALA 10.0 Example 4 ALA 20.0

Experimental Example  1. Average number of hairs and Hair removal effect

(1) Method

A total of 6 test areas (3 x 3 cm) were selected from the test subjects on both calves of the subject, and the compositions for hair removal in Examples and Comparative Examples were applied and then epilated using a hair removal device.

The subjects were selected as 26-35 year old male with hairs on the calf area. Within 3 years, the dermatologist underwent laser or IPL hair removal on the test site, skin, skin sensitization, sensitization, Patients with abnormalities or abnormalities that were judged to be difficult to use by the examiner's judgment were excluded.

In the case of Comparative Example 1, only a safety shaver was used instead of the light-based depilator. In Comparative Example 2 and Examples 1 to 4, the test site was shaved with a safety razor, and then an Intense Pulsed Light (IPL) Using an epilator, light was irradiated at a wavelength of 520 to 1200 nm and an intensity of 5.0 J / cm ² for 0.02 to 0.03 seconds to be epilated.

After obtaining the images after 4, 8, and 12 weeks after the hair removal, the number of hair pieces was determined for each site / parking.

(2) Results

After the hair removal, the average number of hairs and the hair removal effect were measured and are shown in the following Table 2 and Fig.

division Average number of hairs () Hair removal effect (hair loss rate,%) 0 weeks 4 weeks 8 weeks 12 weeks 4 weeks 8 weeks 12 weeks Comparative Example 1 47.5 48.2 51.2 47.3 -1.5 -7.8 0.4 Comparative Example 2 47.1 28.5 22.2 23.8 39.5 52.9 49.5 Example 1 50.3 24.5 22.0 21.5 51.3 56.3 57.3 Example 2 47.5 21.6 18.9 14.5 54.6 60.3 69.5 Example 3 50.9 24.2 22.8 19.4 52.5 55.2 61.9 Example 4 48.5 22.3 14.8 12.2 54.0 69.5 74.8

As shown in Table 2 and Fig. 1, the hair removal effect was insignificant in Comparative Example 1 in which hair removal was performed using only a general epilator.

Examples 1 to 4 using a composition for hair removal containing a photosensitive material showed a superior hair removal effect as compared with Comparative Example 2 using a composition containing no photosensitive material, Of the total.

Claims (8)

(BPD) and sodium formaldehyde (Aldrich), as well as derivatives thereof, such as indocyanine green (ICG), methylene blue, toluidine blue, aminolevulinic acid (ALA), phthalocyanine, porphyrin, texapyrine, bacterioclomer, merocyanine, ≪ RTI ID = 0.0 > 1, < / RTI >
The method according to claim 1,
Wherein the photosensitive material is contained in an amount of 0.001 to 50% by weight based on 100% by weight of the composition for hair removal.
The method according to claim 1,
An anti-inflammatory agent, an anesthetic ingredient, and a sedative agent.
The method according to claim 1,
Wherein the composition is selected from the group consisting of creams, lotions, ointments, skins, gels, skins, mist, and sprays.
The method according to claim 1,
A composition for hair removal used in the use of a light-based hair removal device.
6. The method of claim 5,
The light-based hair removal device is an intense pulse light (IPL) hair removal device or a laser hair removal device.
(BPD) and sodium formaldehyde (Aldrich), as well as derivatives thereof, such as indocyanine green (ICG), methylene blue, toluidine blue, aminolevulinic acid (ALA), phthalocyanine, porphyrin, texapyrine, bacterioclomer, merocyanine, A composition for depilation comprising at least one photosensitive material selected from the group consisting of:
A method of epilation using a light based epilation device.
8. The method of claim 7,
Wherein the hair removal is performed at a wavelength of 400 to 1500 nm at an intensity of 1 to 30 J / cm < ² > for 0.001 to 100 seconds.

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