KR20180011677A - Thermo-sensitive cosmetic composition having property of sol-gel transition - Google Patents

Abstract

Disclosed is a temperature-sensitive cosmetic composition having sol-gel phase transition properties. According to one aspect of the present invention, the temperature-sensitive cosmetic composition stays in a sol form at a room temperature, and is changed into a gel form when the temperature reaches a body temperature. In addition, a temperature-sensitivity in a formula is adjustable depending on purposes through adjustment of a content ratio of a solubilizer, polyol, polyglutamic acid, and collagen, while being harmless to human body by containing collagen which is a biopolymer.

Description

[0001] The present invention relates to a thermo-sensitive cosmetic composition having a sol-gel transition property,

Disclosed herein is a thermosensitive cosmetic composition having sol-gel transfer properties.

Human skin has various functions such as body protection, body temperature control, perception, absorption, secretion, and emotional transmission. These human skin changes over time due to various internal and external factors. There have been a lot of researches on methods and materials which can prevent and ameliorate skin damage and aging phenomenon. Especially, as a formulation for continuously applying and adhering ingredients useful for skin to skin, Many studies have been conducted. These formulations include, for example, cosmetic packs or mask packs, cataplasms, pals, aerosols, lotions, ointments, creams and liquid forms. Among them, the skin- In the form of patches are frequently used. Among them, researches using collagen have been continued, but since collagen has a characteristic of changing into a gel state at room temperature, there is a limit to the inconvenience of use.

KR10-2009-00993267E

In one aspect, an object of the present invention is to provide a thermosensitive cosmetic composition.

In another aspect, an object of the present invention is to provide a cosmetic composition containing collagen, which exists in a sol state at room temperature and transits to a gel state at a body temperature approximate temperature.

In another aspect, an object of the present invention is to provide a cosmetic composition containing collagen which is convenient to use at room temperature.

In one aspect, the present invention provides a thermosensitive cosmetic composition comprising: collagen and polyglutamic acid; Polyol, solubilizing agent, and preservative, wherein the collagen is contained in an amount of 0.1 to 2% by weight based on the total weight of the composition, the polyglutamic acid is contained in an amount of 0.1 to 2% by weight , 0 to 10 wt% of the polyol, 0 to 1 wt% of the solubilizing agent, 0 to 0.5 wt% of the preservative, and the composition is in a sol state at room temperature , And a state of gel at body temperature.

In one aspect, the thermosensitive cosmetic composition is in a sol state at room temperature, but transitions to a gel state at a temperature close to the body temperature. In addition, the content of collagen, polyglutamic acid, polyol, solubilizing agent and the like can be adjusted so that the temperature sensitive property of the formulation can be adjusted according to the purpose of use. In addition, since collagen, which is a biomolecule, is used, there is an advantage that it is harmless to human body.

FIG. 1 is a graph showing viscosity changes of a collagen aqueous solution (FIG. 1A), a polygamma glutamic acid aqueous solution (FIG. 1B), and a mixed aqueous solution of polygamma glutamic acid and collagen (FIG.
FIG. 2 is a diagram showing changes in appearance of a mixed aqueous solution of poly (gamma glutamic acid) and collagen according to the temperature. FIG.
Fig. 3 is a view showing changes in appearance of the composition containing collagen, polygamma glutamic acid, polyol, solubilizing agent and preservative according to the temperature. Fig.
Fig. 4 is a chart showing changes in the appearance of the composition depending on the content ratio of collagen and poly (gamma glutamic acid) in the composition. Fig.

Hereinafter, the present invention will be described in detail.

Collagen and polyglutamic acid; Polyol, solubilizing agent, and preservative, wherein the collagen is contained in an amount of 0.1 to 2% by weight based on the total weight of the composition, the polyglutamic acid is contained in an amount of 0.1 to 2% by weight , 0 to 10 wt% of the polyol, 0 to 1 wt% of the solubilizing agent, 0 to 0.5 wt% of the preservative, and the composition is in a sol state at room temperature And a gel state at body temperature.

Specifically, the collagen may be contained in an amount of 0.1 wt% or more, 0.5 wt% or more, 0.9 wt% or more, 1.3 wt% or more, 1.5 wt% or more, 1.7 wt% or more, or 1.9 wt% , 1.6 wt% or less, 1.1 wt% or less, 0.6 wt% or less, 0.3 wt% or less, or 0.2 wt% or less. The polyglutamic acid may be contained in an amount of 0.1 wt% or more, 0.5 wt% or more, 0.9 wt% or more, 1.3 wt% or more, 1.5 wt% or more, 1.7 wt% or more, or 1.9 wt% Or less, 1.6 wt% or less, 1.1 wt% or less, 0.6 wt% or less, 0.3 wt% or less, or 0.2 wt% or less. The polyol may be present in the composition in an amount of at least 0.1 wt%, at least 1 wt%, at least 3 wt%, at least 5 wt%, at least 7 wt%, or at least 9 wt% 8 wt% or less, 6 wt% or less, 4 wt% or less, 2 wt% or less, or 1 wt% or less. The solubilizing agent may be contained in an amount of 0.1 wt% or more, 0.3 wt% or more, 0.6 wt% or more, 0.9 wt% or more, 0.95 wt% or less, 0.7 wt% or less, 0.4 wt% or less, 0.2 wt% or less Or 0.1% by weight or less. Also, the preservative may be contained in an amount of 0.1 wt% or more, 0.2 wt% or more, 0.3 wt% or more, or 0.4 wt% or more, 0.5 wt% or less, 0.4 wt% or less, 0.3 wt% or less, Or 0.1% by weight or less.

Collagen is the main component of connective tissue and is a protein that accounts for about 30% of total mammalian proteins. Also known as collagen, it exists as a fibrous solid. Collagen exists in fibrous form in animal dermis, cartilage, etc., and becomes collagen fiber. The types of collagen include collagen 1, collagen 2, collagen 3, collagen 5 and collagen 11, fibrous collagen, collagen 4, collagen 6, collagen 7, collagen 8, collagen 9, collagen 10 and collagen 12 .

Collagen is in a sol state, which is usually flowable at a temperature of 4 DEG C or lower, but becomes a gel state at a temperature higher than room temperature.

As used herein, the sol may mean a suspension in which solid colloidal material is dispersed in a liquid phase.

In the present specification, a gel can mean a material in which a dispersed colloidal material is polymerized to form a network structure and is not flowable in a steady state.

In the present specification, the term "polyglutamic acid" means a polymer of glutamic acid obtained by polymerizing glutamic acid with an amide bond. Glutamic acid has a carboxyl group at the carbon at the α-position and the γ-position, and these are bonded to the amino group. polyglutamic acid which is polymerized by the amide bond with the carboxyl group at the? -position and? -Polyglutamic acid when it is the carboxyl group at the? -position. The molecular weight of polyglutamic acid depends on the number of polymerized glutamic acid, and may be about 10,000 to 2,000,000 daltons. The average molecular weight of the polyglutamic acid may be 50 kDa.

In this specification, sol-gel transfer may mean that the sol and gel are transferred from one state to another state by a change in external conditions such as temperature, pressure or pH. For example, it may mean that the gel state changes from a sol state to a sol state or from a gel state to a sol state. The sol-gel transition may be reversible or irreversible.

In this respect, the sol-gel transition of the composition from sol to gel state can take place at any temperature between 30 and 40 [deg.] C. Any one of 30 to 40 占 폚, 31 to 40 占 폚, 32 to 40 占 폚, 33 to 40 占 폚, 34 to 40 占 폚, 35 to 40 占 폚, 39 deg. C, 33 to 38 deg. C, 34 to 38 deg. C, and 35 to 38 deg. C, for example, 31 deg. C, 32 deg. C, 33 deg. C, 34 deg. 36 ° C, 37 ° C, 38 ° C, 39 ° C and 40 ° C, but is not limited thereto. In one embodiment, the composition in the sol state can be transferred to a gel state at a temperature close to body temperature, e.g., about 37 < 0 > C.

In the thermosensitive cosmetic composition according to one aspect of the present invention, the composition may contain polyglutamic acid and collagen in a weight ratio of 1: 0.5 to 8, but is not limited thereto. When polyglutamic acid and collagen are contained in the above weight ratio, the sol-gel transfer characteristics by other components in the composition are little affected.

The weight ratio of polyglutamic acid and collagen contained in the composition is 1: 0.5 to 8, 1: 0.5 to 7, 1: 0.5 to 6, 1: 0.5 to 5, 1: 0.6 to 8, 1: 0.7 1 to 8, 1 to 0.8 to 8, 1 to 0.9 to 8, 1 to 1 to 8, 1 to 0.6 to 7, 1 to 0.7 to 6, or 1 to 0.8 to 5. When the polyglutamic acid and collagen in the composition are contained in a weight ratio of 1: 1 to 4, sol-gel transfer occurs actively at a temperature approximate temperature.

In the above aspect, the collagen may be collagen type I (type I collagen), but is not limited to, collagen 2, collagen 3, collagen 4, collagen 5, collagen 6, collagen 7, collagen 8, collagen 9, Collagen 10, Collagen 11, or Collagen 12. Collagen Type I refers to collagen 1.

In addition, in the above aspect, the polyglutamic acid may be?-Polyglutamic acid (? PGA).

The composition may comprise an aqueous solution of polyglutamic acid and collagen, respectively, or an aqueous solution containing water added thereto after mixing polyglutamic acid and collagen. Poly (gamma glutamic acid) is anionic in aqueous solution, and collagen is cationic in aqueous solution, and they can be ionically bound in aqueous solution. In addition to ionic bonds, collagen and poly (gamma glutamic acid) can bind by hydrogen bonding. The combination of collagen and poly (gamma glutamic acid) is called collagen / poly (gamma) glutamate complex.

In this aspect, the gel may be a hydrogel. In the present specification, a hydrogel refers to a hydrogel in which a hydrophilic polymer that maintains a three-dimensional crosslinked structure swells very rapidly when it comes into contact with an excessive amount of water, so that a large amount of water can be contained in the structure. Gel (hydrogel).

In one embodiment, the composition has a viscosity measured at a shear flow mode of a rheometer (HAKKE Rheostress, Thermoscientific) of 0.4 Pas at 25 < 0 > C, measured by a rheological method, And may have a viscosity of 1.0 ppm. Thus, the composition may be in a gel state at a temperature close to body temperature or body temperature.

In one embodiment, the polyol can be 1,3-butyleneglycolic, and the solubilizing agent is selected from the group consisting of polyethylene glycol-60 Hydrogenated Castor Oil, octyldodeces-16, and poly Sorbate 20, and the preservative is selected from the group consisting of phenoxyethanol, sodium benzoate, 1,2-hexanediol, caprylyl glycoll, and ethylhexyl glycerin It may be more than one selected.

The cosmetic composition may be, for example, a body cosmetic composition, a basic cosmetic composition, a makeup cosmetic composition, and the like, and the formulation is not particularly limited and may be appropriately selected according to the purpose.

For example, the cosmetic composition may be formulated as a basic cosmetic composition such as softening water, nutritional lotion, essence, and the like.

The cosmetic composition contains a cosmetically acceptable medium or base. It may be in any form suitable for topical application, for example as a solution, a gel, a solid or a paste anhydrous product, an emulsion obtained by dispersing an oil phase in water, a suspension, a microemulsion, a microcapsule, a microgranule or an ionic form (liposome) and / In the form of a non-ionic fugant dispersant. These compositions may be prepared according to conventional methods in the art.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

In one embodiment of the present invention, the cosmetic composition may further contain an enhancer. The thickening agent included in the cosmetic composition of the present invention may be selected from the group consisting of methylcellulose, carboxymethylcellulose, carboxymethylhydroxyguanine, hydroxymethylcellulose, hydroxyethylcellulose, carboxyvinyl polymer, polyquaternium, cetearyl alcohol, Carrageenan and the like can be used, and it can be preferably a gourd such as xanthan gum.

In one embodiment of the present invention, the cosmetic composition may contain various bases and additives as appropriate, and the kind and amount of these components can be easily selected by the inventors. The composition may contain an additive that is acceptable according to need, and may further include components such as preservatives, pigments, and additives customary in the art.

The preservative may specifically be phenoxyethanol or 1,2-hexanediol, and the perfume may be an artificial perfume or the like.

And, in one embodiment of the present invention, the cosmetic composition may comprise a composition selected from the group consisting of water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymeric polysaccharides, sphingolipids and seaweed extracts. Examples of the compounding ingredients that may be added include organic solvents such as a preservative component, a moisturizer, an emollient, a surfactant, an organic and inorganic pigment, an organic powder, an ultraviolet absorbent, a preservative, a bactericide, an antioxidant, a plant extract, a pH adjuster, A blood circulation promoter, a cold agent, a restriction agent, and purified water.

The components to be added in addition to these components are not limited thereto, and any of the above components can be compounded within a range that does not impair the objects and effects of the present invention.

Hereinafter, the present invention will be described in more detail with reference to the following examples and experimental examples. However, these examples and experimental examples are provided for illustrative purposes only in order to facilitate understanding of the present invention, and the scope and scope of the present invention are not limited by the following examples.

[Example 1] Viscosity measurement of composition

[Example 1-1] Measurement of viscosity of a composition containing collagen and polygamma glutamic acid

(Bio Reader, Daejeon, Korea) and 20 mg / ml of an aqueous solution of a solution of a collagen aqueous solution and a polygamma glutamic acid aqueous solution in a ratio of 4: 1 in an aqueous solution of 20 mg / ml collagen solution (Bio Land, Cheongju, Korea), 20 mg / ml aqueous solution of polygamma glutamic acid The viscosity was measured by rheometry using a rheometer (HAKKE Rheostress, Thermoscientific) while raising the temperature from room temperature to body temperature (1 캜 / 3 minutes). At this time, the viscosity was measured after keeping the equilibrium state for 1 minute at each temperature.

As a result, it was found that the viscosity of the mixture of the aqueous solution of collagen and the aqueous solution of poly (gamma glutamic acid) was drastically increased at a temperature near the body temperature (about 36.9 ° C) (FIG. 1).

[Example 1-2] Viscosity measurement of a composition containing collagen, polygamma glutamic acid, polyol, solubilizing agent and preservative

When the polyol (1,3-butylene glycol), the solubilizing agent and the preservative were further contained in the collagen and polygamma glutamic acid aqueous solution of Example 1-1, the viscosity of the composition was measured. Emalex HC60 was used as a solubilizer and phenoxyethanol was used as a preservative.

The contents of the polyols, solubilizers and preservatives used in the composition and the resulting viscosities of the compositions are as shown in Table 1 below.

[Table 1]

In Table 1,% means% by weight based on the total weight of the composition.

[Example 2] Observation of appearance change of collagen / poly (gamma glutamic acid) complex aqueous solution with temperature change

The change in turbidity with the temperature of the composition prepared in Example 1-1 was visually observed. For all samples, phase transition and apparent state change with temperature were taken after taking the aqueous mixture mixture at a specific temperature of the thermostat for 5 minutes. As a result, the temperature gradually increased from the room temperature to the approximate temperature, and gradually transitioned from the sol to the gel. The viscosity increased, and the temperature rose to about 40 ° C or higher. (Fig. 2).

[Example 3] Observation of appearance change of composition according to mixing ratio of collagen and polygamma glutamic acid

While varying the content ratio of collagen and poly (gamma glutamic acid), the mixture was heated to 37 DEG C, and viscosities were visually observed after a certain period of time. As a result, it was confirmed that the sol-gel transition was best performed when the weight ratio of both was in the range of 4: 1 (FIG. 4).

Claims (9)

As a thermosensitive cosmetic composition,
The composition may comprise,
Collagen and polyglutamic acid; At least one selected from the group consisting of a polyol, a solubilizing agent, and a preservative,
Based on the total weight of the composition,
The collagen is contained in an amount of 0.1 to 2% by weight,
Wherein the polyglutamic acid is contained in an amount of 0.1 to 2% by weight,
The polyol is included in an amount of 0 to 10% by weight,
The solubilizing agent is contained in an amount of 0 to 1% by weight,
The preservative is included in an amount of 0 to 0.5% by weight,
Wherein the composition is in a sol state at room temperature and in a gel state at body temperature. The method according to claim 1,
The composition may comprise,
Wherein a sol-gel transition from a sol state to a gel state takes place at any temperature between 30 캜 and 40 캜. 3. The method of claim 2,
Wherein the sol-gel transition occurs at any temperature between 34 캜 and 38 캜. The method according to claim 1,
The composition may comprise,
Wherein said collagen and polyglutamic acid are contained in a weight ratio of 0.5 to 6: 1. The method according to claim 1,
Wherein the collagen is collagen type I (type I collagen). The method according to claim 1,
Wherein the polyglutamic acid is?-Polyglutamic acid (? PGA). The method according to claim 6,
Wherein the polygamma glutamic acid has a number average molecular weight of 50 Da. The method according to claim 1,
Wherein the gel is a hydrogel. The method according to claim 1,
Wherein the polyol is 1,3-butyleneglycol,
The solubilizing agent includes at least one selected from the group consisting of polyethylene glycol-60 Hydrogenated Castor Oil, octyldodeces-16 and polysorbate 20,
Wherein the preservative comprises at least one member selected from the group consisting of phenoxyethanol, sodium benzoate, 1,2-hexanediol, caprylyl glycoll, and ethylhexyl glycerin.

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