KR20180005919A - Sticks cosmetic composition containing peptide liposome - Google Patents

Abstract

The present invention relates to a stick type cosmetic composition containing peptide liposome and, more specifically, to a stick type cosmetic composition which can stably contain peptide without elution phenomenon by comprising peptide liposome having specific polyhydric alcohol, and has an effect of skin lifting or the like.

Description

[0001] STICKS COSMETIC COMPOSITION CONTAINING PEPTIDE LIPOSOME [0002]

The present invention relates to a stick-type cosmetic composition comprising a peptide liposome, and more particularly, to a stick-type cosmetic composition which contains a peptide liposome containing a specific polyhydric alcohol and can contain a peptide stably without precipitation, .

Skin is the primary barrier of the human body and protects the internal organs of the body from the external environment such as temperature, humidity change, ultraviolet rays and pollutants, and plays an important role in keeping the body homeostatic such as body temperature control.

As skin ages inevitably, aging occurs and accelerates the skin damage caused by the external environment. In modern society, as the demand for improving the quality of life due to the improvement of the living standard increases, There is a desperate need for measures against skin aging. Researches for improving skin aging by applying cosmetic compositions effective for lifting, wrinkling, elasticity, dark circles, anti-aging and the like have been actively conducted.

In recent years, there has been an effort to prepare a peptide component having efficacy by incorporating a peptide component into a cosmetic composition, but it is difficult to obtain a sufficient effect of the peptide component having a water-soluble peptide component due to its low penetration efficiency, Or water-in-oil (W / O) formulations, which are easy to use, store, and carry.

Korean Patent Publication No. 10-2013-0023912

In order to solve the problems of the prior art, the present invention has been made to solve the problems of the prior art, and it is an object of the present invention to provide a liposome composition which is excellent in lifting, wrinkle, elasticity, whitening (dark circles) improvement, anti- It is an object of the present invention to provide a stick-type cosmetic composition which can be manufactured into a stick-type formulation.

In order to achieve the above object,

The present invention provides a cosmetic composition for skin lifting, which comprises 1 to 7% by weight of a peptide liposome based on the total weight of the composition, and the peptide liposome comprises a peptide, butylene glycol and glycerin.

An embodiment of the present invention is a peptide of the present invention wherein said peptide is selected from the group consisting of Copper tripeptide-1, Tripeptide-29, Tripeptide-1, Acetyl Hexapeptide- -8), Nicotinoyl Tripeptide-35, Hexapeptide-12, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-29, Palmitoyl Tripeptide-1, Nonapeptide-7, Tripeptide-10 citrulline, sh-Polypeptide-15, palmitoyl tripeptide-5, and diaminopropionoyl-tripeptide-33. Tripeptide-33, r-Spider Polypeptide-1, Nonapep-1, tide-1, nonapeptide-27 amide, decapeptide-11, decapeptide-31, digalloyl tetrapeptide-19, Dipeptide-2, and Retinoyl Tripeptide-1. In addition, the present invention is not limited thereto.

The cosmetic composition comprising the peptide liposome of the present invention provides excellent lifting, wrinkle, elasticity, whitening (dark circles) and anti-aging effects, and is excellent in stability and surface state with time, The present invention can be applied to the production of stick-shaped cosmetics.

FIGS. 1 to 4 are graphs showing the results of measurement of the elasticity of the forehead line, ball, under the chin and neck according to Test Example 4. FIG.
5 to 7 are graphs showing results of measurement of lifting degree of eyes, face, and mouth area according to Test Example 5. FIG.
8 is a graph showing the evaluation results of the skin wrinkle improvement according to Test Example 6. Fig.
9 is a graph showing the result of skin whitening evaluation according to Test Example 7. Fig.
10 shows the eye, face and mouth lifting evaluation results of Test Example 5. Fig.
11 shows the neck wrinkle evaluation result of Test Example 6. Fig.

The stick-type cosmetic composition was difficult to contain a water-soluble peptide in a stick-type cosmetic composition due to a large amount of water-free or water-in-oil type (W / O, water in oil).

The present inventors can provide a stick-type cosmetic composition capable of providing the effect of a peptide component by preparing a peptide component that is water-soluble and hard to be included in a water-free formulation or a stick formulation, as a peptide liposome and incorporating it into a stick- Respectively.

In particular, it has been found that the peptide liposome contains a specific polyhydric alcohol and is contained in the composition in a predetermined amount, thereby making it possible to produce a stick-type product having excellent stability and surface condition of the formulation.

Hereinafter, the present invention will be described in detail.

The present invention provides a stick type cosmetic composition comprising 1 to 7% by weight of a peptide liposome based on the total weight of the composition, wherein the peptide liposome comprises a peptide, butylene glycol and glycerin.

The peptide liposome may be a liposome containing a peptide component, and may further include at least one selected from lecithin, emollient, and purified water. In one embodiment, the peptide liposome may comprise a peptide, butylene glycol, glycerin, lecithin, octyldodecanol as an emollient, and purified water as a solvent.

The peptide may be selected from the group consisting of Copper tripeptide-1, Tripeptide-29, Tripeptide-1, Acetyl Hexapeptide-8, Nicotinoyl Tripeptide-35, Hexapeptide-12, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-29, Palmitoyl Tripeptide-1, Nonapeptide-7, Tripeptide-10, -10 Citrulline, sh-Polypeptide-15, Palmitoyl Tripeptide-5, Diaminopropionoyl Tripeptide-33, r- Spider Polypeptide-1, Nonapeptide-1, Nonapeptide-27, Decapeptide-11, Decapeptide-31, Digalloyl Tetrapeptide-19, Dipeptide-2, Dipeptide-2, ) And Retinoyl Tripeptide-1 (Retinoyl Tripeptide-1), but the present invention is not limited thereto. More preferably, it may be at least one peptide selected from caprate tripeptide-1, acetylhexapeptide-8, tripeptide-10 citrulline and nonapeptide-1.

The peptide is preferably contained in an amount of 0.01 to 15% by weight, more preferably 0.01 to 2% by weight, based on the total weight of the peptide liposome. If the content is less than 0.01% by weight, the effect of improving the skin such as lifting, whitening and anti-aging may not be exhibited. If the content is more than 15% by weight, skin irritation may be caused by the content increase. And there may be a problem that precipitation of peptides occurs.

The butylene glycol and glycerin are polyhydric alcohols, and the polyhydric alcohol is preferably contained in an amount of 10 to 60 wt%, more preferably 30 to 40 wt%, based on the total weight of the peptide liposome. If the content is less than 10% by weight, the moisturizing effect may be deteriorated. If the content is more than 60% by weight, the content may be separated due to a problem of poor usability with oils.

At this time, the weight ratio of butylene glycol and glycerin is preferably 1: 5 to 5: 1, more preferably 1: 1.

The peptide liposome may further include at least one selected from the group consisting of propylene glycol, pentylene glycol, hexylene glycol, and diglycerin in addition to butylene glycol and glycerin as polyhydric alcohols.

The lecithin is a phospholipid containing glycerophosphoric acid as an important component of the cell membrane, and dissolves in ethanol, ether and the like and acts as an emulsifier to form an emulsion with water. Fatty acids that make phospholipids are mainly stearic acid, palmitic acid, oleic acid, and linoleic acid. They are natural ingredients and have no irritation to the skin and are biodegradable and environmentally friendly.

The content of the lecithin is preferably 0.01 to 10% by weight, more preferably 0.1 to 5% by weight based on the total weight of the peptide liposome. If the content of lecithin is less than 0.01% by weight, the emulsifying power may be weak and the liposome may not be formed. If the content exceeds 10% by weight, precipitation of lecithin may occur.

The emollient serves as an oil for wrapping the outer portion of the water in oil (W / O) liposome formulation. Specific examples thereof include octyldodecanol, diisostearyl malate, caprylic / At least one selected from the group consisting of glycerin, glycerin, glycerin, glycerin, glycerin, glycerin, glycerin, glycerin, glycerin, glycerin, , And more preferably octyldodecanol.

The emollient is preferably contained in an amount of 1 to 60% by weight based on the total weight of the peptide liposome because it is an optimal condition for forming a liposome.

The purified water may be contained in the peptide liposome in a residual amount.

The composition of the present invention comprises 1 to 7% by weight, more preferably 1 to 5% by weight, and still more preferably 2.5 to 5% by weight of the peptide liposome. When the content of the peptide liposome is out of the above range, the stability of the composition is lowered, the stability of the product produced by the composition is lowered, and the surface condition becomes poor.

The cosmetic composition of the present invention may further comprise at least one component selected from natural waxes, natural oils and bulking agents.

The natural wax may be selected from the group consisting of vegetable wax, animal wax, mineral wax, and mixtures thereof. Examples of the vegetable wax include Candelilla wax and Carnauba wax. Examples of the animal wax include bees wax and lanolin wax. Examples of the mineral wax include paraffin wax, (Paraffin), Microcrystalline Wax, Ozokerite, Ceresin.

The natural oils may be selected from the group consisting of sunflower seed oil, avocado oil, orange oil, macadamia seed oil, lemon oil, pine nut oil, jojoba seed oil, olive oil, green tea seed oil, coconut oil, rosehip oil, Seed oil, drumstick seed oil, grapefruit seed oil, soybean oil, and vanilla fruit oil.

Examples of the bulking agent include talc, mica, silica, polymethyl methacrylate, silica silylate, vinyl dimethicone / methicyl silsesquioxane crosspolymer, polymethylsilsesquioxane, nylon-12, nylon-6, cellulose, kaolin At least one member selected from the group consisting of titanium dioxide, zinc oxide, magnesium stearate, barium sulfate, boron nitride, corn starch, synthetic fluorine fluorite, polyethylene, zeolite and silica dimethysilylate can be used.

In addition, the composition of the present invention may further contain other ingredients known in the art such as preservatives, coloring agents, flavoring agents, cosmetic nutrition ingredients and the like.

The stick-type cosmetic composition of the present invention can be used in various formulations known in the art and is selected from the group consisting of, for example, transparent sticks, transparent sticks, opaque sticks, opaque sun sticks, It may be one type of formulation, more preferably a transparent stick, a transparent sun stick, an opaque stick or an opaque sun stick.

The stick-type cosmetic composition of the present invention may more preferably be a non-aqueous stick-type cosmetic composition.

Hereinafter, the present invention will be described in more detail with reference to examples. However, the following examples are provided to illustrate the present invention, and the present invention is not limited by the following examples, but may be variously modified and changed.

< Manufacturing example > Peptides Liposomal  Produce

Peptide liposomes of Preparation Example 1 and Comparative Preparation Examples 1 to 4 were prepared with the compositions and contents (unit: wt%) shown in Table 1 below in order to evaluate the presence or absence of polyhydric alcohols and their stability.

Concretely, the water phase was dispersed in purified water until it became colorless transparent under the conditions of 60 ° C, and after mixing and stirring, the high pressure micro homogenizer (X120, CAT, Germany) After passing the solution, the oil phase was stirred vigorously under a condition of 75 ° C, the water phase was slowly added to the mixture, and the mixture was cooled to 30 ° C to prepare a peptide liposome.

division Production Example 1 Comparative Preparation Example 1 Comparative Production Example 2 Comparative Production Example 3 Comparative Production Example 4 Paid Octyldodecanol 45 45 45 45 45 Awards Copper tripeptide-1 2 2 2 2 2 Butylene glycol 20 40 - - glycerin 20 - 40 - Pentyleneglycol 40 lecithin 5 5 5 5 5 Purified water 8 8 8 48 8

< Test Example >

Test Example  One.

The stability and transparency of the peptide liposomes prepared in Preparation Example 1 and Comparative Preparations 1 to 4 were measured according to the conditions (at a constant temperature of -10 ° C, 0 ° C, 25 ° C, 45 ° C and 55 ° C) for 3 months, The results are shown in Table 2 below.

<Evaluation Criteria>

◎: maintain transparency after room temperature recovery, no precipitation phenomenon

X: No transparency after room temperature recovery, Crystal precipitation

division Production Example 1 Comparative Preparation Example 1 Comparative Production Example 2 Comparative Production Example 3 Comparative Production Example 4 transparency ◎ X X X X Stability ◎ X X X X

As can be seen from the results of Table 2 and FIG. 1, the stability and transparency of the liposome were low in Comparative Production Examples 1 to 4, while the peptide liposome of Production Example 1 showed excellent stability and transparency.

< Example  And Comparative Example >

Example  One. Peptides Liposomes  Containing Cosmetics  Preparation of composition

(Examples 1 to 2 and Comparative Examples 2 to 3) containing peptide liposomes prepared using both butylene glycol and glycerin as polyhydric alcohols were prepared,

The cosmetic compositions of Examples 1 to 2 and Comparative Examples 1 to 3 were prepared with the composition and the content (unit: wt%) shown in Table 3 below.

Specifically, the peptide liposome was prepared in the same manner as in the above-mentioned preparation example. The peptide liposome prepared by heating the natural wax at 90 ° C was completely dissolved, and the prepared liposome and natural oil were completely dissolved at 80 ° C, and the bulking agent was added And completely dispersed at 80 캜. Thereafter, the container was filled in a stick container and cooled.

ingredient Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Peptide liposome Octyldodecanol 1.125 2.25 - 3.375 4.5 Copper tripeptide-1 0.05 0.1 - 0.15 0.2 Butylene glycol 0.5 One - 1.5 2 glycerin 0.5 One - 1.5 2 lecithin 0.125 0.25 - 0.375 0.5 Purified water 0.2 0.4 - 0.6 0.8 natural
Wax Beads wax 15 15 15 15 15 Ozokerite 15 15 15 15 15 natural
oil Jojoba seed oil 10 10 10 10 10 Sunflower seed oil 47.5 45 50 42.5 40 Bulking agent Silica 5 5 5 5 5 Polymethyl methacrylate 5 5 5 5 5

Test Example  2.

The stability of the cosmetic compositions of Examples 1 to 2 and Comparative Examples 1 to 3 over time was measured according to the conditions (temperature of the incubator-10 ° C, 0 ° C, 25 ° C, 45 ° C and 55 ° C) , And the results are shown in Table 4 below.

The surface state of the stick formulation according to the content of the peptide liposome in the whole composition was visually confirmed, and the results are shown in Table 4 below.

division Example 1 Example 2 Comparative Example 1 Comparative Example 2 Comparative Example 3 Stability ◎ ◎ ◎ ◎ X Surface condition ◎ ◎ ◎ X X

As shown in Table 4,

In Examples 1 and 2 and Comparative Example 1 not containing liposomes, the stability and surface state were excellent, and Comparative Examples 2 and 3 were found to have poor stability and / or surface state.

Even though peptide liposomes are stably prepared on the basis of the above preparation examples and used in stick-type cosmetic compositions, the content of peptide liposomes is very important for the production of stick-type cosmetics. When the content of the peptide liposomes is out of the range, Which means that the compatibility between the components contained in the composition is lowered and the stability is lowered.

In Comparative Example 2, the stability was excellent, but the surface state was poor. In Comparative Example 3, both the stability and the surface state were poor, and it was confirmed that the product was difficult to produce.

Test Example  3. Peptides Liposome  Stick type according to content Cosmetics  Evaluation of skin stability of composition

For evaluating the stability of the compositions of Examples 1 and 2 and Comparative Example 1 in which the stability and the surface condition were satisfactory, a human skin patch test was conducted.

Twenty-four hours after the application of the formulations of Examples 1 and 2 and Comparative Example 1 were performed on the inside of the upper arm of 30 healthy adults without any history of allergic contact dermatitis or atopic dermatitis, .

Immediately after removal of the patches, 1 hour after the removal, and 24 hours after the removal, the skin condition was visually observed and evaluated according to the intensity of the stimulation. The results are shown in Table 5 below.

division Example 1 Example 2 Comparative Example 1 Degree of stimulation No stimulation No stimulation No stimulation

As shown in Table 5, all of the compositions of Examples 1 and 2 and Comparative Example 1 were confirmed to be a safe formulation without skin irritation due to no irritation.

Test Example  4. Peptides Liposomes  Stick type Cosmetics  Evaluation of skin elasticity improvement of composition

In order to evaluate the skin elasticity improvement of Example 2 in which the stability and the surface condition are good, a human body application test was conducted. The skin elasticity was measured using a ballistometer. The elasticity of the forehead line, ball, chin, and neck was measured before the test product was used, after 2 weeks of use, and after 4 weeks of use, And Figs. 1 to 4.

The measured elasticity parameter was Alpha value, and the average value measured three times was used as the skin elasticity evaluation data. The measured value is inversely proportional to the skin elasticity, which means that the skin elasticity is improved as the measured value is lowered.

As can be seen from Tables 6 to 9 and FIGS. 1 to 4, the elasticity of the forehead line, ball, chin, and neck after use of Example 2 was measured after 2 weeks and 4 weeks (P <0.05). There was no statistically significant difference between the two groups.

As the measured value is inversely proportional to the skin elasticity, the skin elasticity is improved as the measured value is lowered. Thus, it is confirmed that the skin elasticity can be significantly improved when the product is used.

Test Example  5. Peptides Liposomes  Stick type Cosmetics  The skin of the composition lifting  Effect evaluation

Using Example 2, which has good stability and surface condition, a human body application test was conducted for skin lifting evaluation.

The skin lifting effect was measured by using Image Pro Plus, an image analysis program, after taking an entire image of the face using F-ray, which is a kind of Moire equipment. After 2 weeks and 4 weeks after using the test product, The degree of lifting at the mouth area was measured and shown in Tables 10 to 12 and Figs. 5 to 7 below.

The angle of contours formed around each measurement area was used as the evaluation data. The lifting angle measurement at the eye and mouth area is proportional to the lifting improvement, and the lifting angle measurement at the facial area is inversely proportional to the lifting improvement.

As shown in Tables 10 to 12 and FIGS. 5 to 7, the degree of lifting of eyes, face and mouth after use of Example 2 was examined. As a result, alpha value was measured at 2 weeks and 4 weeks after use , And in the face, statistically significant decrease was observed. In the case of eyes and mouth, it was statistically significantly increased.

In other words, it was confirmed that the use of the product can have a significant effect on lifting of eyes, face and mouth.

Test Example  6. Peptides Liposomes  Stick type Cosmetics  Evaluation of skin wrinkle improvement of composition

Using Example 2, which has good stability and surface condition, a human body application test was conducted to evaluate the improvement of skin wrinkles.

Skin wrinkles were measured with Antera 3D before and after 2 weeks and 4 weeks of use. The degree of the wrinkles was analyzed by specifying a specific region of the photographed image and used as the evaluation data of the wrinkles of the skin. The measured wrinkles are overall size, and the analytical value and the degree of wrinkles are in inverse proportion, which means that wrinkles are improved as the analysis value is lowered.

As can be seen from Table 13 and FIG. 8, after 2 weeks and 4 weeks from the use of the product, the degree of neck wrinkles was statistically significantly decreased as a result of evaluation of neck wrinkles after use of Example 2, The effect was confirmed.

Test Example  7. Peptides Liposomes  Stick type Cosmetics  Evaluation of skin whitening (dark circles improvement) effect of the composition

Using Example 2, which has good stability and surface condition, a human body application test was conducted for skin whitening evaluation.

Skin whitening was measured by three times of Melanin index (MI) in the dark circles under the eyes at the 2 weeks and 4 weeks after using the test product using Mexameter. Dark circles) were used as evaluation data. The unit of measured melanin index is A.U (Arbitrary Unit). Since the measured value and the melanin index are in proportion to each other, it means that dark circles of the skin are improved as the MI value is lowered. This means that there is a whitening effect.

As shown in the above Table 14 and FIG. 9, the evaluation of dark circles improvement after use of Example 2 showed that the degree of melanin under the eyes was statistically significantly higher than that of the product before and after 2 weeks and 4 weeks of use Respectively. That is, it was confirmed that the product is effective for improvement of dark circles and whitening.

Claims (9)

And 1 to 7% by weight, based on the total weight of the composition, of a peptide liposome,
Wherein the peptide liposome comprises a peptide, butylene glycol, and glycerin. The method according to claim 1,
The peptide may be selected from the group consisting of Copper tripeptide-1, Tripeptide-29, Tripeptide-1, Acetyl Hexapeptide-8, Nicotinoyl Tripeptide-35, Hexapeptide-12, Hexapeptide-9, Palmitoyl Pentapeptide-4, Palmitoyl Tetrapeptide-7, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-29, Palmitoyl Tripeptide-1, Nonapeptide-7, Tripeptide-10, -10 Citrulline, sh-Polypeptide-15, Palmitoyl Tripeptide-5, Diaminopropionoyl Tripeptide-33, r- Spider Polypeptide-1, Nonapeptide-1, Nonapeptide-27, Decapeptide-11, Decapeptide-31, Digalloyl Tetrapeptide-19, Dipeptide-2, Dipeptide-2, ) And retinoyl tripeptide-1 (Retinoyl Tripeptide-1). The method according to claim 1,
Wherein the peptide liposome further comprises at least one selected from lecithin, emollient, and purified water. The method according to claim 1,
Wherein the peptide liposome comprises 0.01 to 15% by weight of the peptide based on the total weight of the peptide liposome. The method according to claim 1,
Wherein the peptide liposome comprises 10 to 60% by weight of the butylene glycol and glycerin based on the total weight of the peptide liposome. The method of claim 5,
Wherein the butylene glycol and glycerin are in a weight ratio of 1: 5 to 5: 1. The method according to claim 1,
Wherein the composition further comprises at least one member selected from natural waxes, natural oils and bulking agents. The method according to claim 1,
Wherein the composition has an effect of improving skin lifting, wrinkles, elasticity, whitening or anti-aging. The method according to claim 1,
Wherein the cosmetic composition is one kind of a formulation selected from the group consisting of a transparent stick, a transparent sun stick, an opaque stick, an opaque sun stick, a transparent hair, a transparent sunburn and a powder.

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