KR20170138737A - Oral composition for alleviating hyperesthesia - Google Patents

Abstract

The present invention relates to an oral composition for alleviating hyperesthesia comprising deacylated gellan gum and a divalent metal ion. The oral composition can maintain the sense of use of an existing preparation for treating hyperesthesia, can rapidly inhibit hyperesthesia phenomenon which appears when dental tubes are exposed and is effective in alleviating hyperesthesia in the long term.

Description

[0001] The present invention relates to an oral composition for alleviating hyperesthesia,

The present invention relates to an oral composition having an effect of sensitizing the teeth to hypersensitivity, and more particularly, to a composition for alleviating the hypersensitivity of teeth by containing deacylated Gellan gum and a divalent metal ion The present invention relates to an oral composition for relieving sensory depression.

The sensation of the teeth is a symptom of the dentin being exposed to the outside because the gums are recessed due to gum disease or wrong brushing, and the stimulation is transmitted to the nerve by the temperature, pressure, chemical stimulation through the exposed dentinal tubules, and sharp and violent pain .

There are two main methods for relieving the symptoms of sensory hypersensitivity. In the case of neuron dampening, it is a method to alleviate the sensory hypersensitivity by suppressing the transmission of the nerve from the external stimulus. In the case of neuron dampening, it is known that potassium ion must be supplied continuously since potassium ion concentration should be formed high around the nerve, and it takes about 2 weeks until the effect of relieving the hypersensitivity symptoms as a cauterization agent. Potassium salts, including potassium nitrate, are mainly used for nerve insensitivity.

It is a technique to artificially block exposed ivory tubules in the case of an iv tubule occlusion. Techniques to block ivory tubules using exposed powdered microflora and organic polymers have been developed. This is a technique for blocking the exposed iv tissue using fine powder such as tricalcium phosphate which is similar to the tooth constituent. However, there is a technical limitation in that when the dentinal tubular blockade is performed through the toothpaste, adhesion of the fine powder is not convenient and the adhesiveness is poor, and the blocking power of the dentinal tubule is low.

In order to solve the above problems, the present invention provides an oral composition for alleviating the symptoms of hypersensitivity, comprising a deacylated gellan gum and a source of a divalent metal ion as an active ingredient to block the exposed iv iv tubuli, And to provide an oral composition for alleviating the symptoms of hypersensitivity.

In order to achieve the above object,

The present invention relates to an oral composition for relieving sensation of hypersensitivity, which comprises deacylated gellan gum and a divalent metal ion.

The present invention relates to an oral composition for relieving sensory depression comprising deacylated gellan gum and a divalent metal ion. The present invention provides an oral composition for relieving sensory irritation, In addition, the effect of delayed hypersensitivity is excellent in the long term.

FIG. 1 is a photograph of an untreated tooth specimen taken by SEM, showing the exposed dental tubules.
FIG. 2 is a photograph of an exposed dentinal tubule taken by SEM when the composition of Example 1 of the present invention is treated once with a cut tooth specimen. FIG.
FIG. 3 is a photograph of the dentinal tubule exposed by the composition of Example 2 of the present invention once treated with a cut tooth specimen using SEM. FIG.

Hereinafter, the present invention will be described in detail.

The present invention relates to an oral composition for relieving sensational hypersensitivity, which comprises deacylated gellan gum and a divalent metal ion.

The oral composition for relieving sensory hypersensitivity can supply dentin with a divalent metal ion bonded to the surface of the deacylated gellan gum particle to effectively block the exposed dentinal tubules and alleviate or prevent the hypersensitivity.

In the present invention, the polysaccharide produced in the metabolic process of the gellan black Sphingomonas elodea microorganism is composed of 1: 1: 2 ratio of rhamnose, gluconic acid and glucose, and the acyl group is removed by using alkali in the recovery process. And gellan gum which does not remove the acyl group.

The physical properties of gellan gum may vary depending on the presence or absence of the gellan black acyl group.

Deacylated gellan black exhibits very good transparency, acid resistance and heat resistance. In addition, it has a characteristic of forming a gel through binding with a divalent metal ion such as calcium and magnesium, and can be utilized for various purposes for the purpose of gelling agents such as foods and drinks. In particular, it can be used for maintaining viscosity in the case of oral products.

In one embodiment of the present invention, the deacylation of the gellan gum is carried out by treating the gellan gum produced by the Sphingomonas elodea microorganism with an alkali to remove the acyl group. Through the alkali treatment, acetyl groups and glycerates, which are bonded to gellan gum, are removed and deacylated.

In one embodiment of the present invention, a deacylated gellan gum which forms a gel through binding with the gellan gum bivalent metal ion is preferred.

The content of the deacylated gellan gum is preferably 0.1 to 2% by weight, more preferably 0.5 to 1% by weight based on the total weight of the composition.

When the content of the deacylated gellan gum is less than 0.1% by weight, the ability to transfer bivalent metal ions to the surface of the dentin decreases and the ability to alleviate the hypersensitivity deteriorates. If the amount of the deacylated gellan gum is more than 2% by weight, The surface may become uneven and the appearance may be poor.

In one embodiment, the divalent metal ion is preferably at least one selected from the group consisting of calcium ion, magnesium ion, copper ion and zinc ion.

More preferably, the bivalent metal ion is calcium chloride, which forms calcium phosphate by reacting with phosphate ions present in the oral saliva to block the exposed dermal tubules.

The content of the divalent metal ion is preferably 0.01 to 2% by weight, more preferably 0.05 to 0.5% by weight based on the total weight of the composition.

When the content of the divalent metal ion is less than 0.01% by weight, the amount of the metal ion transferred to the dentin by the gellan gum is so small that it is difficult to exhibit the effect of inhibiting the hypersensitivity. When the content of the divalent metal ion is more than 2% by weight, And the usability is deteriorated due to the taste.

The oral composition may be of gel or liquid type, but is not limited thereto.

In one embodiment of the present invention, the oral composition may further include at least one additive selected from wetting agents, sweeteners, abrasives, viscosity regulators, surfactants and brighteners, but is not limited thereto.

The wetting agent is at least one selected from glycerin, sorbitol, polyethylene glycols and propylene glycol.

The sweetener is at least one selected from the group consisting of saccharin, xylitol, erythritol, sodium saccharin, and aspartame.

The abrasive is at least one selected from the group consisting of silica, silica gel, zirconium silicate, calcium monohydrogenphosphate, anhydrous calcium hydrogenphosphate, hydrated alumina, hard calcium carbonate, heavy calcium carbonate, calcium pyrophosphate, insoluble metaphosphate and aluminum silicate .

The viscosity adjusting agent is at least one selected from carboxymethyl cellulose, carbomer, xanthan gum and alginate.

The surfactant is at least one selected from cocamidopropyl betaine, polyoxyethylene, polyoxypropylene condensation polymer, polyoxyethylene hydrogenated castor oil, sodium lauryl sulfate and sodium lauryl sarcosinate.

Also, in the present invention, a brightener such as titanium oxide (TiO 2) may be used for enhancing whiteness of the oral composition.

According to an embodiment of the present invention, there is provided a method for preparing an oral composition for relieving sensational hypersensitivity comprising deacylated gellan gum and a divalent metal ion, the method comprising: ionizing the divalent metal ion by dissolving the divalent metal ion in a liquid phase containing purified water; And introducing the deacylated gellan gum into a liquid phase containing the divalent metal ion.

In other words, it can be prepared by adding a deacylated gellan gum to a solution in which the divalent metal ion is dissolved in purified water, and then binding a divalent metal ion to the surface of the gelatin gel.

The manufacturing method according to the present invention is simpler than the process of hydrating gellan gum into hydrothermal water dissolved with a metal ion sequestering agent and then injecting metal ions to form a gel and has a low energy consumption for heating and cooling, And it is effective.

The divalent metal ion may be included in the composition of the present invention in an amount of 0.01 to 2% by weight, preferably 0.05 to 0.5% by weight based on the total weight of the composition. have.

The content of the deacylated gellan gum may be 0.1 to 2% by weight, preferably 0.5 to 1% by weight based on the total weight of the composition.

Hereinafter, the present invention will be described in detail with reference to examples and comparative examples. However, the embodiments according to the present invention can be modified in other forms, and the present invention is not limited to the embodiments described below.

[ Test Example  1] ivory customs Degree of containment  Measure

In order to measure the degree of occlusion of dentinal tubules, the composition for oral use (Example 1) and the composition for oral use according to the present invention (Comparative Examples 1 to 5) were prepared as shown in Table 1 below.

Example 1 was prepared by dissolving deacylated gellan gum and calcium chloride, which is a divalent metal ion, in an aqueous solution containing water, sorbitol, uniformly mixing the liquid phase with an abrasive and a viscosity adjusting agent, stirring the mixture, .

Comparative Examples 1 to 5 were prepared in the same manner as in Example 1 with the components shown in Table 1 below.

The degree of blocking of dermal tubules was measured using the thus prepared Example 1 and Comparative Examples 1 to 5.

The tooth specimens were cut and the oral compositions of the examples and comparative examples were diluted 1: 1 with artificial saliva in a tooth specimen exposed to the dentinal tubules, and the specimens were washed with purified water for 3 minutes using a power toothbrush and dried. The degree of occlusion of the dentinal tubules was measured by SEM and the degree of occlusion of the dentinal tubules was compared and evaluated.

Example 1 Comparative Example 1 Comparative Example 2 Comparative Example 3 Comparative Example 4 Comparative Example 5 Sorbitol 50 50 50 50 50 50 Purified water Balance Balance Balance Balance Balance Balance Calcium chloride 0.5 - - 0.5 - 0.5 Sodium saccharin hydrate 0.2 0.2 0.2 0.2 0.2 0.2 Silica 19 19 19 19 19 19 Carboxymethylcellulose 0.5 0.5 0.5 0.5 One One The deacylated gellan gum One One - - - - Gellan gum - - One One - - Titanium oxide 0.5 0.5 0.5 0.5 0.5 0.5 incense Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Cocamidopropyl betaine 2.4 2.4 2.4 2.4 2.4 2.4 Degree of vascular occlusion ◎ △ X ○ X X

Legend

◎: Exposed ivory tubules more than 70% blocked

○: Exposed dentinal tubules were blocked by 50% or more

△: Exposed dentinal tubules were blocked by 30% or more

X: Less than 30% containment of exposed iv tissue

As shown in Table 1, the result of dentinal tubule blockade showed that dentifrice capillary blockade was excellent in a composition in which deacylated gellan gum and calcium chloride were present together. In the case of Comparative Example 1 in which there was no calcium chloride The degree of dermal tubule occlusion was finer than that of Example 1

In Comparative Example 2, gellan gum was contained, but in the absence of calcium chloride, there was no degree of dermal tubular blockade.

In addition, in Comparative Example 3 containing gellan gum, the degree of blocking of dental tubules was lower than that of Example 1 containing deacylated gellan gum.

Comparative Example 4 containing only carboxymethylcellulose and Comparative Example 5 containing only calcium chloride and carboxymethylcellulose showed no degree of dermal tubular occlusion.

Therefore, it was confirmed that the oral composition containing the deacylated gellan gum and the calcium chloride together with calcium ion, which is one of the divalent metal ions, was superior in the degree of ivory tubule occlusion and was able to inhibit the hypersensitivity .

[ Test Example  2] Gellan gum  Ivory customs by concentration Degree of containment  Measure

To determine the degree of vascular occlusion according to the concentration of deacylated gellan gum, an oral composition was prepared as shown in Table 2 below to measure the degree of vascular occlusion. Examples and Comparative Examples were prepared and tested in the same manner as in Test Example 1.

Example 2 Example 3 Example 4 Comparative Example 6 Sorbitol 50 50 50 50 Purified water Balance Balance Balance Balance Calcium chloride 0.5 0.5 0.5 0.5 Sodium saccharin hydrate 0.2 0.2 0.2 0.2 Silica 19 19 19 19 Carboxymethylcellulose 0.5 0.5 0.5 0.5 The deacylated gellan gum 0.5 One 2 - Titanium oxide 0.5 0.5 0.5 0.5 incense Suitable amount Suitable amount Suitable amount Suitable amount Cocamidopropyl betaine 2.4 2.4 2.4 2.4 Degree of vascular occlusion ○ ◎ ◎ △ Exterior ◎ ○ △ ◎

When the content of deacylated gellan gum was more than 1% by weight as in Examples 2 to 4 of Table 2, the degree of blocking of dental tubules was not increased any more, and the appearance was not uniform as the deacylated gellan gum increased Respectively.

Also, in Comparative Example 6, which did not contain deacylated gellan gum, the degree of blocking of dermal tubules was found to be low.

[ Test Example  3] Dentinal tubules according to calcium ion concentration Degree of containment  Measure

To determine the degree of vascular occlusion according to calcium ion concentration, an oral composition was prepared as shown in Table 3 below to measure the degree of vascular occlusion. The examples and comparative examples were prepared and tested in the same manner as in Test Example 1.

Example 5 Example 6 Example 7 Comparative Example 8 Sorbitol 50 50 50 50 Purified water Balance Balance Balance Balance Calcium chloride 0.5 One 2 - Sodium saccharin hydrate 0.2 0.2 0.2 0.2 Silica 19 19 19 19 Carboxymethylcellulose 0.5 0.5 0.5 0.5 The deacylated gellan gum One One One One Titanium oxide 0.5 0.5 0.5 0.5 incense Suitable amount Suitable amount Suitable amount Suitable amount Cocamidopropyl betaine 2.4 2.4 2.4 2.4 Degree of vascular occlusion ◎ ◎ ◎ △ flavor ◎ ◎ △ ◎

As shown in Examples 5 to 7 of Table 3, it can be seen that the increase in the calcium chloride content increases the dermal tubule blocking effect. When the calcium chloride content was 0.5% by weight or more, the effect of blocking the ivory tubules was not further increased. When the calcium ion content exceeded 2% by weight, the quality was poor due to the specific taste of the metal ion.

Also, in Comparative Example 8, which does not contain calcium chloride, the degree of blocking of ivory tubules is lowered.

Through the above test, it can be confirmed that the oral composition for hypersensitivity mitigation comprising hypoacylglycerol and divalent metal ions effectively blocks the dentinal tubules that are exposed and effectively alleviates the hypersensitivity.

Claims (9)

Wherein the composition comprises deacylated gellan gum and a divalent metal ion.
The method according to claim 1,
Wherein the deacylated gellan black is contained in an amount of 0.1 to 2% by weight based on the total weight of the composition.
The method according to claim 1,
Wherein the divalent metal ion is contained in an amount of 0.01 to 2% by weight based on the total weight of the composition.
The method according to claim 1,
Wherein the divalent metal ion is at least one selected from the group consisting of calcium ion, magnesium ion, copper ion and zinc ion.
The method according to claim 1,
Wherein the oral composition further comprises at least one additive selected from the group consisting of wetting agents, sweeteners, abrasives, viscosity regulators, surfactants and brighteners.
The method according to claim 1,
Wherein the oral composition is gel or liquid. ≪ RTI ID = 0.0 > 11. < / RTI >
Ionizing the divalent metal ions by dissolving them in purified water; And
And adding the deacylated gellan gum to a liquid phase containing the divalent metal ion.
8. The method of claim 7,
Wherein the divalent metal ion is contained in an amount of 0.01 to 2% by weight based on the total weight of the composition. 8. The method of claim 7,
Wherein the deacylated gellan black composition comprises 0.1 to 2% by weight based on the total weight of the composition.

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