KR20170094758A - Method of Manufacturing Composition for Catheter - Google Patents

Abstract

The present invention relates to a method for producing a composition used in foley catheters. To this end, dispersed carbon nanotube (CNT) and zinc oxide (ZnO) are added in silicone so as to produce a material in which a CNT polymer is mixed in silicone.

Description

TECHNICAL FIELD The present invention relates to a method for manufacturing a catheter,

The present invention relates to a method of making a composition for use in a poly catheter.

In general, patients with systemic or paraplegic paralysis caused by cerebral diseases such as stroke or spinal injuries are increasing year by year due to an increase in the elderly population and a rapid increase in traffic accidents or industrial accidents.

In this patient, bladder paralysis is inevitably accompanied by treatment of the bladder paralysis, which is entirely dependent on the prognosis of the patient, and a polycatheter (Foley Catheter) is maintained in the bladder as a treatment for these patients, do.

The poly-catheter is configured such that poly (Foley) is attached to the distal end portion of the tubular catheter body so that the poly is inflated by the fluid introduced from the outside to have a balloon shape so that the catheter is held in the bladder.

In the case of a conventional antibiotic catheter, an antibiotic drug or a substance is applied to a poly catheter made of a silicone to suppress invasion of bacteria. Although antibiotics are initially effective in antibiotics, biofilm formation is inevitable due to intubation of the urinary tract for 2 to 3 days due to the nature of the catheter.

Such biofilm formation causes the antibiotic effect of the poly catheter to drop or disappear, resulting in complications such as urinary tract infection, and the procedure is accompanied with a problem that the length of hospitalization is prolonged.

In addition, since conventional anticancer drugs or substances applied to the surface of the conventional catheter catheter are always kept in the joint, urinary tract infections and stones are formed, resulting in renal failure in about 40% of all patients. .

On the other hand, in order to solve the problem of the above-mentioned antibiotic catheter, there is a product in which a catheter is coated with an antimicrobial substance such as gold, silver or silver nano. However, when the antimicrobial substance is used over a certain period of time,

The recognition of the problems and problems of the prior art is not obvious to a person having ordinary skill in the art, so that the inventive step of the present invention should not be judged based on the recognition based on such recognition I will reveal.

It is an object of the present invention to provide a method for producing a composition for use in a poly catheter, which has improved antibacterial properties and is capable of maintaining antibacterial property even after prolonged use.

The method for preparing a composition for a poly catheter according to an embodiment of the present invention comprises dispersing carbon nanotubes and zinc oxide (ZnO) in combination with silicon to form a material in which a carbon nanotube polymer (CNT polymer) is mixed with silicon .

According to an embodiment of the present invention, a catheter body and a catheter poly are made of a material in which carbon nanotube (CNT) polymer combined with zinc oxide (CNT) is mixed with silicon, It is possible to inhibit the formation of a biofilm, which is the root of bacterial infection, without application or coating.

In addition, it has an effect of maintaining antibacterial property by mutating inactivating bacteria of poly-stenosis by maintaining induction effect of carbon nanotube polymer with bio-potential uniformly in poly.

The catheter poly according to the present invention has no side effects such as antibiotic resistance and is characterized in that the lifetime of the carbon nanotube polymer is determined by the amount of electrostatic capacitance possessed by the carbon nanotube polymer, It has the effect of minimizing the rejection of the patient during the insertion process, reducing the additional replacement cost and preventing the increase of medical expenses due to the infection.

The effects of the present invention described above are only one of various effects according to the present invention, and the present invention can be realized in various forms according to the application method of the embodiments.

1 is a perspective view showing a configuration of a poly catheter according to an embodiment of the present invention.
2 is a cross-sectional view showing an example of a sectional configuration of the polycatheter shown in Fig.
FIGS. 3 to 8 are diagrams showing experimental results on biofilm formation inhibitory effect of the material constituting the poly catheter and the catheter poly.
Fig. 9 is a view showing experimental results for explaining the effect of reducing the foreign body sensation when a human body is inserted into a poly catheter and a catheter poly.
10 is a view for explaining the configuration and operation of a catheter poly according to an embodiment of the present invention.
Figure 11 is a more detailed view of one embodiment of the configuration of a catheter poly according to the present invention.
Figs. 12 to 16 are cross-sectional views showing examples of the cross-sectional configuration of the catheter poly shown in Fig.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Reference will now be made in detail to the preferred embodiments of the present invention, examples of which are illustrated in the accompanying drawings.

The foregoing objects, features and advantages of the present invention will become more apparent from the following detailed description taken in conjunction with the accompanying drawings. DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS Reference will now be made in detail to the preferred embodiments of the present invention, examples of which are illustrated in the accompanying drawings. Like reference numerals designate like elements throughout the specification. In the following description, well-known functions or constructions are not described in detail since they would obscure the invention in unnecessary detail.

FIG. 1 is a perspective view of a configuration of a poly catheter according to an embodiment of the present invention, and FIG. 2 is a cross-sectional view of the poly catheter taken along line BB of FIG. 1 .

A catheter according to an embodiment of the present invention may be a urine catheter for discharging urine in a bladder of a patient and includes a urine inlet and an inflatable poly in the form of a balloon at one side of the catheter body, And a main pipe positioned at the center of the main body communicates with a urine discharging part located on the other side of the main body to discharge urine in the bladder of the patient.

However, the catheter and catheter poly according to an embodiment of the present invention may be applied to various catheters such as a cardiovascular catheter, in addition to the urethral catheter as described above.

Referring to Figures 1 and 2, a polycatheter comprises a catheter body 100, which is a tubular tube, and a poly (200) catheter 200 that is joined to the catheter body 100 to be inflatable by an externally introduced fluid, .

More specifically, the catheter main body 100 may be formed with fluid passages 120 and 121 in which one end 50 is closed, and a urine passage 110 in which urine moves and fluid passages 120 and 121, respectively.

The urine inlet 11 is connected to the urine passage 110 of the catheter body 100 and the fluid outlet 21 can be connected to the fluid passages 120 and 121 of the catheter body 100.

2, a catheter and a catheter for a catheter according to an embodiment of the present invention have been described by taking as an example a catheter body 100 having one urine passage 110 and two fluid passages 120 and 121, The present invention is not limited thereto.

For example, one fluid passageway may be formed in the catheter body 100 and may be a three-way catheter rather than a two-way catheter as shown in FIG. In the case of the catheter, a chemical passage (not shown) may be additionally provided for introducing the medicine separately from the urine passage 110.

The fluid passages 120 and 121 described above are connected to the fluid outlet 21 so that the fluid introduced from the outside through the fluid inlet 23 flows through the fluid passages 120 and 121 and the fluid outlet 21 The catheter poly 200 can be delivered to the jointed portion.

Here, the fluid may be a gas such as air or a liquid such as saline.

The poly (200) for catheter is composed of a material which can expand or contract as the fluid flows, and can be bonded to the catheter body (100) while surrounding the fluid outlet (21) formed in the catheter body (100).

The poly catheter and the catheter poly according to an embodiment of the present invention having the configurations described with reference to Figs. 1 and 2 are made of a material in which carbon nanotube polymer (CNT polymer) is mixed with silicone, It is possible to inhibit the formation of a biofilm, which is the root of bacterial infection, without application or coating of antibiotics.

Carbon nanotubes (CNTs) are cylindrical crystals made of a carbon source and have a diameter of 2 to 20 nm (1 nm to 1 / 1,000,000 m) and a length of several hundred to several thousand nm. One carbon atom in a carbon nanotube forms a hexagonal honeycomb pattern by sp2 bonding with three other carbon atoms around it, which is called a nanotube because the diameter of the tube is very small, about nanometers (nm).

The carbon nanotube polymer (CNT polymer) is a polymer in which carbon nanotubes (CNT) and zinc oxide (ZnO) are bonded, and carbon nanotubes (CNT) and zinc oxide (ZnO) Zinc oxide (ZnO) can be polymerized at a higher ratio than carbon nanotubes (CNT), and vice versa, if necessary.

The catheter body 100 constituting the catheter according to an embodiment of the present invention may be composed of a material blended with 1.0 to 2.2 parts by weight of carbon nanotube polymer relative to 100 parts by weight of silicon, May be variable.

According to the present invention, the carbon nanotube polymer as a constituent of the catheter body 100 has a constant capacitance in response to the potential in the intubated human body, so that such a capacitance is harmless to the human body, but has a catastrophic electrostatic effect effect, which minimizes biofilm formation, and minimizes the rejection of the person during the human body insertion process due to the high thermal conductivity of carbon nanotubes.

In the case of a catheter coated or coated with a conventional antibiotic, it is impossible to use the catheter for more than one week due to biofilm formation and bacterial infection. However, the poly catheter according to the present invention is a CNT ploymer having the above- Can be used for at least 4 to 5 weeks due to the presence of silicon.

According to an embodiment of the present invention, the carbon nanotube (CNT) may be a multi-walled carbon nanotube (MWNT), which may be a multi-walled carbon nanotube (MWNT) And it is likely to be commercialized in terms of price.

As described above, the poly catheter and the catheter poly according to an embodiment of the present invention include a carbon nanotube polymer (CNT polymer) having carbon nanotubes (CNT) and zinc oxide (ZnO) It can be composed of material blended with silicone.

Wherein m, n and p represent the number of molecules of silicon, zinc oxide (ZnO) and carbon nanotubes (CNT), m is from 50 to 300, n is from 7 to 30, p is from 10 to 50 But the present invention is not limited thereto.

On the other hand, in the catheter and the catheter poly, the above-mentioned m, n, and p may be set to be different from each other.

The catheter body 100 and the catheter poly 200 for constructing the catheter according to an embodiment of the present invention may be formed of a carbon nanotube polymer (CNT) and a zinc oxide (ZnO) CNT polymer) and silicone in a certain ratio, and may be formed into a tubular tube.

Here, the material may be formed by compounding carbon nanotubes (CNT) and zinc oxide (ZnO) dispersed using a CVD composite in silicon. For example, a pressure of 1,000,000 Pa and a pressure of 50 Lt; 0 > C under a temperature of about 30 minutes.

Accordingly, a carbon nanotube polymer composed of carbon nanotubes (CNT) and zinc oxide (ZnO) can be uniformly adhered to silicon, so that the catheter made of the material and the poly for the catheter can be uniformly It can have antibacterial activity.

Hereinafter, the biofilm formation inhibiting effect of the material constituting the poly catheter and the poly for the catheter according to one embodiment of the present invention will be described with reference to FIGS. 3 to 8. FIG.

3 to 5 show that Escherichia coli, a major strain of urinary tract infection, was cultured on a catheter slice composed of the above materials for 3 days, 5 days, and 7 days, respectively, and then CV (Crystal Violet) The biofilm formation rate was measured by using an optical microscope.

3, when E. coli. (Escherichia coli.) Was cultured for 3 days, the average value of the absorbance was 0.303 when the blending ratio of zinc oxide (ZnO) was 0%, and the average value of zinc oxide ) Was 1%, the average value of absorbance was 0.326. When the compounding ratio of zinc oxide (ZnO) was 2%, the average value of absorbance was 0.252, and the mixing ratio of zinc oxide (ZnO) In case of 3%, the average value of absorbance was measured as 0.299.

4, when E. coli. (Escherichia coli.) Was cultured for 5 days, the average value of absorbance was 0.362 when the blending ratio of zinc oxide (ZnO) was 0%, and the average value of zinc oxide ) Was 1%, the average value of the absorbance was measured to be 0.380. When the compounding ratio of zinc oxide (ZnO) was 2%, the average value of the absorbance was 0.356 and the mixing ratio of zinc oxide (ZnO) In case of 3%, the average value of absorbance was measured as 0.448.

5, when E. coli. (Escherichia coli.) Was cultured for 7 days, the average value of absorbance was measured to be 0.486 when the blending ratio of zinc oxide (ZnO) was 0%, and the average value of zinc oxide ) Was 1%, the average value of the absorbance was measured to be 0.425. When the compounding ratio of zinc oxide (ZnO) was 2%, the average value of the absorbance was 0.407 and the mixing ratio of zinc oxide (ZnO) In the case of 3%, the average value of the absorbance was measured as 0.413.

FIG. 6 is a graph showing the results of the experiment by the experimental materials, and FIG. 7 is a graph showing the results of the experiments according to the culturing time.

According to the experimental results shown in FIGS. 3 to 6, in the case of a material in which silicon and carbon nanotubes (CNT) are blended (zinc oxide (ZnO) 0%), the average value of the absorbance rapidly increases over time, The biofilm formation is increased.

On the other hand, in the case of a material in which 1% of zinc oxide (ZnO) is blended with silicon and carbon nanotube (CNT), the absorbance is lower than that of a material in which silicon and carbon nanotube (CNT) are blended (zinc oxide (ZnO) And the formation of the biofilm is suppressed to some extent.

In the case of a material in which 2% of zinc oxide (ZnO) is blended with silicon and carbon nanotube (CNT), a material (zinc oxide (ZnO) 0%) and zinc oxide (carbon nanotube ZnO) was lower than that in the case of 1% mixed material, and thus the effect of inhibiting biofilm formation on E. coli (Escherichia coli.), The major strain of urinary tract infection, is clearly shown.

In the case of a material containing 5% of zinc oxide (ZnO) in silicon and carbon nanotube (CNT), the average value of absorbance during 7 days of culture was lower than before, .

Based on the above-mentioned experimental results, when a catheter and a catheter poly are composed of silicon and carbon nanotube (CNT) mixed with about 2% of zinc oxide (ZnO), E. coli (Escherichia coli.) Can be stably achieved.

8 shows the result of culturing E. coli. (Escherichia coli.) For 7 days on a material having a blending ratio of zinc oxide (ZnO) of 1% and then photographing the result of the experiment with a scanning electron microscope (SEM) .

8, after 7 days of culture, E. coli. It can be seen that the microorganisms do not form a biofilm by aggregation.

Also, referring to the experimental results shown in Table 1 below, the material constituting the poly for the catheter and the catheter according to an embodiment of the present invention is described in E. coli. In addition to bacteria, staphylococcus, pneumococcus, Escherichia coli and Pseudomonas aeruginosa have a bactericidal reduction rate of more than 99.9% and bacteriostatic reduction rate.

On the other hand, the catheter and catheter poly configured as described above can minimize the patient's rejection feeling in the process of inserting the human body due to the high heat conduction characteristic of the carbon nanotube.

9 is a graph showing the results of experiments for explaining the effect of reducing the foreign body sensation upon insertion of a human body into a poly catheter and a poly catheter. FIG. 9 (a) shows the thermal conductivity 9 (b) is a thermal image of a catheter made of silicon in which carbon nanotubes are internalized.

9 (a) and 9 (b), it can be seen that in the case of a catheter made of silicon in which carbon nanotubes are internalized, the temperature distribution is uniform due to high heat conduction.

FIG. 10 is a view for explaining the configuration and operation of the catheter poly according to the embodiment of the present invention. The description of the same components as those described with reference to FIGS. 1 to 9 will be omitted hereunder do.

Referring to FIG. 10, a catheter body 100 is formed with a urine inlet 11 and a catheter poly 200 adjacent one end 50 of the poly catheter that is inserted into the bladder.

The catheter poly 200 may expand to form a balloon when fluid (e.g., air or saline) enters the fluid inlet 23 provided on the other side of the catheter.

For example, the fluid may be introduced in a manner such that a fluid is previously injected into a syringe, the syringe needle is inserted into the inflow hole 22 at the end of the fluid inflow portion 23, and the syringe is compressed.

A catheter poly 200 configured to abut one end 50 of the catheter body 100 is inserted from the fluid inlet 23 into the bladder through the fluid passages 120 and 121 and the fluid outlet 21 As the fluid enters the catheter poly 200, the catheter poly 200 bulges in a balloon fashion and spans the bladder neck 60 to secure the catheter within the bladder.

A urine passage 110 connected to the urine inlet 11 is formed at the center of a cross section of the catheter body 100 and a urine outlet 13 is formed at the end of the urine passage 110.

For example, the urine generated in the urethra flows into the urine passage 110 through the urine inlet 11 located in the urethra, and then flows into the urine outlet 12, which is the end of the urine outlet 13, Lt; / RTI >

Fig. 11 shows one embodiment of the configuration of the catheter poly 200 according to the present invention, in which the portion of the catheter poly 200 shown in Figs. 1 and 11 is shown enlarged will be.

11, bonding surfaces 210 and 211 are formed at both ends of the catheter poly 200 to be connected to the catheter body 100 and the catheter poly 200 is inserted into the catheter body 100, The bonding surfaces 210 and 211 may be bonded to the catheter body 100 using an adhesive.

Hereinafter, a method for manufacturing a poly catheter and a method for forming a poly for a catheter according to an embodiment of the present invention will be described with reference to FIG.

First, as described above, a carbon nanotube polymer (CNT polymer) in which carbon nanotubes and zinc oxide (ZnO) are combined is extruded into a tubular tube to form a catheter body 100.

In addition, the carbon nanotube and zinc oxide (ZnO) -containing carbon nanotube polymer (CNT polymer) are extruded or injected into a tubular tube to form a poly (200) for a catheter.

Here, the blending ratio of the carbon nanotube, zinc oxide (ZnO), or carbon nanotube polymer as a raw material for producing the catheter body 100 and the mixing ratio of the carbon nanotube, zinc oxide (ZnO) or carbon nanotube polymer may be different.

For example, when the poly (200) for a catheter is inflated by a fluid introduced from the outside, the surface area is increased, and thus the distribution of the carbon nanotube polymer per unit area is decreased, and the antibacterial ability may be lowered.

As described above, if the poly (200) for catheter is inflated and the antibacterial power is lowered, even if formation of biofilm is inhibited in the catheter body 100, a biofilm is formed in the catheter poly (200) have.

According to one embodiment of the present invention, the ratio of the carbon nanotube polymer of the catheter poly 200 is preferably higher than the proportion of the carbon nanotube polymer of the catheter body 100, The distribution of the carbon nanotube polymer per unit area has the same or similar range as that of the catheter main body 100 even when inflated, so that uniform antimicrobial force can be maintained regardless of the position of the poly catheter.

Assuming that the catheter poly 200 expands and the surface area increases by about 4 to 6 times, as described above, the catheter body 100 is made of a material mixed with 1.0 to 2.2 parts by weight of carbon nanotube polymer relative to 100 parts by weight of silicon When constructed, the poly (200) for a catheter may consist of a material blended with 4.0 to 13.2 parts by weight of carbon nanotube polymer relative to 100 parts by weight of silicone in proportion to an increase in surface area.

On the other hand, in the case of the poly (200) for a catheter, it may be desirable that the values of n and m in the formula (1) increase in proportion to the increase in surface area upon expansion of the catheter poly (200).

After the catheter body 100 and the catheter poly 200 are prepared, the abutment surfaces 210 and 211 of the catheter poly 200 are attached to the catheter body 100 and the urine A poly catheter can be manufactured by forming a tip having an inlet 11.

The method of manufacturing a poly catheter according to an embodiment of the present invention and the method of forming a poly for a catheter may further include additional steps such as a drying step in addition to the steps described above and a separate step May be added.

Figs. 12-16 show cross-sectional views of examples of the cross-sectional configuration of the catheter poly shown in Fig.

12 is a cross-sectional view taken along the CC line shown in Fig. 11, showing a structure in which the catheter poly 200 is wrapped around the catheter body 100 having the urine passage 110 and the fluid passages 120 and 121 Lt; / RTI >

Here, when the catheter poly 200 is manufactured using a material having a higher mixing ratio of the carbon nanotube polymer than the catheter body 100, the catheter body 100 and the catheter poly The current can flow until the potential difference between the source and drain electrodes 200 disappears.

This is because zinc oxide (ZnO) creates a high dislocation and current flows from the catheter body 100 to the catheter body 100 at the abutting portions, and between the catheter body 100 and the catheter poly 200 When the potential difference is lost, when the poly 200 for catheter is inflated, the electrostatic capacitance is lowered and the antibacterial ability may be decreased.

An insulating layer 900 is interposed between the catheter body 100 and the catheter poly 200 as shown in Figure 13 to prevent current from flowing from the catheter poly 200 to the catheter body 100, .

The insulating layer 900 may be composed of a gas such as an air layer or a sterilizing gas layer (for example, EO gas), or a carbon nanotube coating layer having a high concentration.

By preventing the electric current from flowing from the poly 200 for catheter to the catheter body 100 by the insulating layer 900, the potential difference due to the difference in the mixing ratio of the carbon nanotube polymer can be maintained, The antibacterial force can be maintained in the same or similar range as the catheter body 100 even when inflated.

The catheter body 100 and the catheter poly (200) are formed during the formation of the catheter poly 200 such that an insulating layer 900 is formed between the catheter body 100 and the catheter poly 200, 200 or an EO gas treatment or a high-concentration carbon nanotube coating process may be added to the outer surface of the catheter body 100.

FIG. 14 is a cross-sectional view taken along the line D-D shown in FIG. 11, showing a cross-sectional structure of a portion of the abutment surface 210 where the catheter poly 200 is bonded to the catheter body 100.

Referring to FIG. 14, an insulating film 1000 may be formed on a bonding surface 210 where the catheter poly 200 is bonded to the catheter body 100.

This is because when the adhesive used to bond the junction surface 210 of the catheter poly 200 to the catheter body 100 is conductive, the potential difference due to the difference in the mixing ratio of the carbon nanotube polymer causes the junction surface 210 Because the current can flow from the poly (200) for a catheter to the catheter body 100 through the insulating layer (1000).

For example, the insulating film 1000 may be formed by coating a high-concentration carbon nanotube on the bonding surface 210 as a carbon nanotube insulating film, and when the poly (200) for a catheter is inflated, It may be dismantled.

The insulating film 1000 as shown in FIG. 14 is also preferably applied to a cardiovascular catheter.

FIG. 15 is a cross-sectional view taken along the line E-E shown in FIG. 11, showing a cross-sectional structure of a portion where the fluid outlet 21 is formed.

Referring to FIG. 15, fluid outlets 21a and 21b may be formed at positions corresponding to the two fluid passages 120 and 121 formed in the catheter body 100, respectively.

The fluid introduced from the outside flows through the fluid passages 120 and 121 of the catheter body 100 and then flows out through the fluid outlets 21a and 21b to the poly 200 for catheter, The poly 200 is expanded by the pressure of the fluid.

16 is a cross-sectional view illustrating the expanded state of the poly (200) for catheter.

Referring to FIG. 16, by increasing the compounding ratio of the carbon nanotube polymer of the poly (200) for catheter to that of the catheter body 100 so as to be proportional to the rate of increase of the surface area upon expansion, The electrostatic capacitance of the poly (200) for the catheter may be kept the same or similar to that of the catheter body 100, so that the antibacterial force of the poly catheter can be uniform.

Although not shown separately in the drawing, steps according to the manufacturing method may be added or reduced depending on the type or function of the catheter or catheter poly according to the present invention.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is clearly understood that the same is by way of illustration and example only and is not to be construed as limiting the scope of the invention as defined by the appended claims. It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention.

Claims (4)

A method of making a composition for use in a poly catheter,
A method for manufacturing a composition for a poly catheter, comprising the step of compounding dispersed carbon nanotubes and zinc oxide (ZnO) with silicon to form a material in which carbon nanotube polymer (CNT polymer) is blended with silicon. The method according to claim 1,
Wherein the carbon nanotube polymer is blended in an amount of 4.0 to 13.2 parts by weight based on 100 parts by weight of silicone when used in a catheter poly. The method according to claim 1,
Wherein the carbon nanotube polymer is used in an amount of 1.0 to 2.2 parts by weight based on 100 parts by weight of silicone when used in a catheter body. The method of claim 1, wherein the carbon nanotubes
A composition for a poly catheter, the multi-walled carbon nanotube (MWNT).

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