KR20170084866A - Silicone pad having highly moisture composed Functional composition for wound healing - Google Patents

Abstract

The present invention relates to a silicone pad for skin reconstitution containing a functional ingredient.
Accordingly, the technical point of the present invention is to provide a silicone polymer-based skin rehabilitation and treatment (beauty and medical use) pad forming crosslinking by adding a diphenylsiloxane oil so that the molecular structure becomes an extended or bulky structure, (So as to impregnate more) or to penetrate the entire amount (to make more bare) due to molecular chain pore enlargement.

Description

Technical Field [0001] The present invention relates to a silicone pad for skin reconstruction containing a functional ingredient,

The present invention relates to a silicone polymer-based skin rehabilitation and treatment (cosmetic and medical) padded pad crosslinking method wherein a diphenylsiloxane oil is added so that the molecular structure becomes an extended type or a root structure, (To allow more penetration) or to penetrate the entire amount (to make more bare) due to enlargement of the skin.

That is, the present invention provides a method for dispersing an effective substance (active ingredient) on a silicone pad composition having adhesive properties based on diphenylsiloxane oil, wherein the dispersed effective substance (effective ingredient) So that the movement of the oil can quickly reach the affected part.

First, there are two types of treatments for injuries resulting from surgery or recall.

The first is the treatment of wounds, and the second is the treatment of scars (scars).

The problem is that the end of wound healing is not the beginning of scarring, and the first treatment of scarring is to use a gel sheet.

Scars are formed in response to skin damage as part of the natural wound healing process, and wound healing is usually perceived to occur in stages, but is a long, continuous process.

This process begins with inflammation immediately after injury. During this step, which typically lasts from 2 days to 1 week (depending on the wound), damaged tissue and foreign matter are removed from the wound.

The proliferative phase occurs at the same time after the inflammatory phase and is characterized by fibroblast proliferation and collagen and proteoglycan production.

The extracellular matrix is synthesized during the proliferation step to provide structural integrity to the wound.

The proliferative phase usually lasts from about 4 days to several weeks, depending on the nature of the wound, and during this step usually a thickening scar is formed.

Thereafter, during the remodeling phase, the previously constructed and optionally organized substrate is remodeled into a highly cross-linked, aligned and structured structure with increased mechanical strength.

The histologic features that characterize hypertrophic scars have been well documented, but the underlying pathophysiology is not well known.

Hypertrophic scarring is a side effect of excessive wound healing and generally results in overproduction of cells, collagen and proteoglycans.

Typically, these scars are elevated and are characterized by any distribution of tissue bundles. The appearance (ie, size, shape, and color) of these scars varies depending on the area of the body in which they are formed and the underlying ethnicity of the affected person.

Hypertrophic scarring is very common and can occur after total thickness damage to the skin.

Recently, it has been reported in the rat model that mechanical stress can increase hypertrophic scarring, as described in U.S. Patent Application Publication No. 2006/0037091 (filed on May 24, 2005, entitled " Method for Producing Hypertrophic Scarring Animal Model for Identification of Agents for Prevention and Treatment of Human Hypertrophic Scarring, "U.S. Patent Application 11 / 135,992).

Typically, keloids are characterized by tumors composed of highly hyperplastic masses that develop in the dermis and adjacent subcutaneous tissue, most commonly in sensitive individuals.

While hypertrophic scars tend to remain confined within the original scar boundary, keloids are more dangerous than hypertrophic scars because they tend to invade normal adjacent tissues.

Previous attempts to treat scarring and keloids include surgery, silicone dressings, steroids, x-ray irradiation and cryotherapy.

Each of these techniques leads to some drawbacks. The biggest drawback is that none of them effectively prevents or improves the formation of scar or keloids first.

In other words, these techniques have already been used to treat these scars after they have been completely fixed.

Thus, there is a need for devices and methods for preventing or ameliorating scarring and / or keloid formation.

Meanwhile, the methods of transdermal drug delivery include membrane controlled systems, adhesive dispersion type systems, matrix diffusion controlled systems, and micro- -reservoir dissolution controlled system).

In a membrane control system, the drug storage layer is typically surrounded by an impermeable membrane, such as aluminum coated plastic, and a polymer membrane (release control membrane), which controls the permeation rate. The drug storage layer contains the drug in a polymer matrix They are dissolved or suspended in a uniformly distributed or highly viscous liquid phase and released through the release control membrane.

The emission control film may or may not have a fine porous structure with a well-known transmittance.

The exterior of the release control membrane is compatible with the drug and has a structure that can be attached to the skin using a pressure sensitive adhesive that does not cause an hypersensitive reaction such as skin eruption.

In addition, the adhesive dispersion type system is a simplified form of the above-mentioned membrane control system, and instead of completely surrounding the drug storage layer, the adhesive is directly applied to adhesives such as rubber, acrylic, And the solution is applied to the impermeable support layer as a single layer or multilayer by casting or hot melt method.

Alternatively, a drug-free thin adhesive film having constant permeability on the top of the drug storage layer may be used.

Matrix diffusion controlled systems are used to create a drug storage layer in which the drug is dispersed in a hydrophilic or lipophilic polymer matrix and to form an occlusive base to prevent diffusion in opposite directions in a device made of impermeable plastic plate.

Unlike the other two systems mentioned earlier, the adhesive is not applied over the entire surface but rather is applied to the edge of the matrix where the drug is dispersed.

A micro-reservoir dissolution controlled system formulation is a composite of a membrane controlled system and an adhesive dispersion type system.

First, the drug is suspended in an aqueous solution of a water-soluble polymer, and then the drug suspension is prepared by dispersing fine drug storage layer particles which are not released by mechanical force into the liposoluble polymer.

The thermodynamically unstable dispersion system is formed by crosslinking the polymer chains immediately and stabilizing the polymer discs. The polymer discs containing the drug are attached to the center of a pad of a pressure sensitive adhesive pad.

The conventional percutaneous absorption system mentioned above has an advantage that it can release the drug for a long time to continuously maintain the effective blood concentration and can be used for a drug having a short half-life.

However, in these systems, there are limitations on rapid drug delivery due to delay in absorption of drugs and the like, and there is a disadvantage that drug is crystallized on the preparation when high concentration of drug is used to increase skin absorption efficiency.

Generally, patches used in cosmetics are adhesive dispersed type, and hydrogel patches using sodium alginate, chitosan, or the like are generally used, such as casting a gel having an adhesive force to a nonwoven fabric.

These patches generally have a disadvantage in that they have a low skin adhesion force, are dried at the time of use, are easily separated from the skin, and thus have a short usable time.

This negative feature is due to the low tackiness of the formulation itself and the lack of adequate flexibility required to closely adhere to the bending of the body, such as the face.

In summary, silicone gel sheets have been used to treat skin wounds (burns, wounds, surgical stains, skin tissue wounds, etc.) caused by internal and external factors for the past 20 years.

The effectiveness of the silicone gel sheet is such that the sheet remains in the affected area by blocking the moisture emanating from the skin, and the addition of dimethyl silicone oil, a composition of the silicone sheet, .

However, conventional silicone sheets can be used for wound close, and because the bacteria of the skin or the lesion grows due to the greenhouse effect of the silicone sheet, the infections such as inflammation are caused, resulting in an unsanitary environment The problem that causes is continuing.

1. Patent Application No. 10-2010-0112469 (Published Oct. 19, 2010)

Accordingly, a method of imparting antimicrobial and sustained-release properties to the sheet has been developed.

Silicon is originally a network structure so that it can move freely. However, the benzene ring of diorganosiloxane oil can be applied to widen the pore of the network structure. Then, the silicone is stirred so as to disperse the antimicrobial substance in the diorganosiloxane oil When added to a silicone base and crosslinked, the silicone sheet becomes a more muscular network structure, and the wider network space absorbs or exudes the active material contained in the diorganosiloxane oil more smoothly.

Since silicon has basically a network structure, oxygen has a very high oxygen permeability, and by increasing the network structure, it is possible to contain an effective component and to have a sustained release property.

If the sheet has antimicrobial properties, early application of the sheet when it enters the proliferative phase increases the healing effect and reduces the risk of secondary infection.

It is also expected to be applied to other skin diseases due to its high moisture retention, antibacterial properties, and skin adhesion.

In other words, the present invention is characterized in that an active ingredient is added to a diorganosiloxane oil-diorganosiloxane oil containing an active ingredient to be dispersed, and then the polymer base is agitated and crosslinked by molding.

As described above, the present invention has been made to solve the above-mentioned problems, and it is a technical object of the present invention to provide a silicone polymer-based skin rehabilitation and treatment (beauty and medical use) The active ingredient of the contained functional ingredient is absorbed by the molecular chain pore enlargement so as to be absorbed more (impregnate more) or to penetrate the whole amount (to make more bare) due to the addition of the oil. The present invention has been made to solve the above problems.

In other words, the present invention is directed to dispersing an effective substance (active ingredient) on a silicone pad composition having adhesive properties based on diphenylsiloxane oil, wherein the dispersed effective substance (active ingredient) So that the movement of the oil can be quickly reached to the affected part.

In addition, the present invention can be applied to a region having a high mobility (such as a joint elbow, a heel, a shoulder, a knee, and the like) because the fixing band can be attached by incorporating a fabric during cross- .

In order to accomplish the above object, the present invention provides a silicone polymer having a single molecular chain crosslinking point in each of R < _{2 >} SiO < (Dipenyl siloxane) is contained so as to be molecular-bonded to the silicone polymer to expand the intermolecular pores of the silicone polymer so that the active material (active ingredient) of the functional ingredient is absorbed or absorbed in a large amount.

Accordingly, it is preferable that the functional ingredient contains a chitosan component as an example and has a molecular weight of 1500000 to 2000000 g / mol and a degree of deacetylation of 99%.

The adhesive layer preferably has a tensile strength of 80 to 100 cN / cm 2 and an adhesive strength of 200 to 250 gmf / cm 2.

As described above, the present invention allows the diphenylsiloxane oil to be added so that the molecular structure of the silicone polymer-based skin re-construction and treatment (beauty and medical use) There is an effect that the molecular chain pore enlargement causes massive absorption (more impregnation) or penetration (more barely).

That is, the present invention provides a method for dispersing an effective substance (active ingredient) on a silicone pad composition having adhesive properties based on diphenylsiloxane oil, wherein the dispersed effective substance (effective ingredient) So that the movement of the oil makes it possible to quickly reach the affected part.

The present invention has the effect of inhibiting the formation of scarring and inhibiting the proliferation of other skin bacterium in the proliferating step in which scars are formed.

FIG. 1 is a view showing a single layer structure of a silicon pad according to the present invention,
FIG. 2 is an illustration showing a molecular structure of a silicone polymer according to the present invention,
3 is an illustration showing the formula of the diphenylsiloxane oil according to the present invention,
FIG. 4 is a graph showing an antibacterial activity versus concentration of a cellulose solution according to the present invention,
5 is an exemplary view showing a state where a fixing band is bonded to a silicon pad according to another embodiment of the present invention.

DETAILED DESCRIPTION OF THE PREFERRED EMBODIMENTS The present invention will be described in detail below with reference to the accompanying drawings.

1 to 3, the present invention is characterized in that a functional component is contained in a silicone polymer having a network structure in which one molecular chain crosslinking point is included in each of R < _{2 >} SiO & Respectively.

The silicone polymer may be selected from the group consisting of polydimethylsiloxane, vinyl silicone polymer, hydrogen silicone polymer, methyl silicone polymer, dimethicone, Cyclomethicone or a copolymer based thereon, silicones including dimethicone copolyol cross-polymer dimethicone, acryl-based polymers including polyacrylate, polyisobutylene, or a mixture thereof desirable.

Such a silicone polymer has excellent self-adherence to the skin, has no irritation and is excellent in human fitness, and has good permeability of various active ingredients including moisture and air. In addition, it has appropriate elasticity and flexibility, and has various advantages in that it can be controlled in various ways according to its composition.

The non-adhesive layer may be formed on the back surface of the adhesive layer. The non-adhesive layer may be formed of at least one selected from the group consisting of polyvinyl acetate, ethyl cellulose, polymethyl methacrylate, methacryloyl ethyl betaine-methacrylate copolymer ethyl betaine / methacylate copolymer, methacrylic acid copolymers, aminoalkyl methacrylate copolymers, cellulose acetate phthalate, polyvinyl pyrrolidone / vinyl acetate copolymers acetate copolymer, hydroxypropyl cellulose, hydroxypropylmethyl cellulose, hydroxyethyl cellulose, hydroxypropylethyl cellulose, polyethylene terephthalate, polyethylene, poly Propylene, polyvinyl Preferably the composition distribution of metal, textile, or a mixture thereof - low-grade, silicone matrix, the urethane matrix, rubber, metal foil-class, the polymer.

As shown in FIG. 2, the pressure-sensitive adhesive layer contains a diphenyl siloxane to be molecularly bonded to the silicone polymer, thereby expanding the intermolecular pores of the silicone polymer, so that the active material (active ingredient) Absorbed or entirely penetrated.

As an example of such a functional ingredient, chitosan components may be contained, and if necessary, extracts of burdock, willow, green tea, paya, and phytosphingosine, which are known to have antibacterial and anti-inflammatory actions, can be used.

At this time, the chitosan component is prepared in the form of a solution, which is formed so as to produce a chitosan solution by using an acidic solution, preferably formic acid, sulfuric acid, hydrochloric acid, acetic acid solution (high molecular weight or low molecular weight chitosan solution)

The main function of these chitosan components is to provide moisturizing, anti-fungal properties.

At this time, the prepared chitosan solution is prepared at a concentration of 1 to 3% by weight. When the concentration exceeds the above range, it is difficult to obtain uniformity due to a high viscosity at the time of mixing. There is a problem, and it is preferable that the concentration is in the above range.

In addition, the concentration of the acidic solution used in the production of the chitosan solution is preferably 0.5 to 5% by volume so that complete dissolution of the chitosan is possible.

The chitosan component is preferably contained in an amount of 0.001 to 30% by weight, more preferably 1,500 to 2,000,000 g / mol, and a deacetylation degree of 99% based on the weight of the adhesive layer.

Accordingly, the adhesive layer of the present invention is effective for problematic skin and wound care by effective chitosan ingredient, and exhibits effects of skin whitening, slimming, wrinkle reduction, wrinkle suppression, anti-aging, and atopic improvement.

The adhesive layer preferably has a tensile strength of 80 to 100 cN / cm 2 and an adhesive strength of 200 to 250 gmf / cm 2.

As shown in FIG. 5, since the fixing band can be attached by incorporating a fabric during cross-linking or by cross-linking as shown in FIG. 5, it is possible to attach a fixing band to a portion having high mobility (joint elbow, heel, shoulder, knee And the like).

In addition, the fixing band is an optional embodiment, and it is preferable that the fixing band is widely bonded in the form of a tape on the upper surface or the lower surface of the pad forming the thickness layer so as to be fixed to the skin.

In addition, the fixing band may be fixed to the skin by forming a bonding band in one direction and the other direction, respectively, as in the case of a clock band.

It will be understood by those skilled in the art that various changes in form and details may be made therein without departing from the spirit and scope of the present invention as defined by the appended claims and their equivalents. Of course, such modifications are within the scope of the claims.

Claims (3)

A silicone polymer having a single molecular chain cross-linking point in each of R < _{2 >} SiO < ₂ > molecular structures of about several hundreds or more includes a functional component in a silicone polymer to form a single layer adhesive layer, Characterized in that it contains diphenyl siloxane so as to expand the intermolecular pores of the silicone polymer so that a large amount of the active substance (active ingredient) of the functional ingredient is absorbed or penetrated the entire amount. The silicone pad for skin reconstruction according to claim 1, wherein the functional ingredient is a chitosan ingredient having a molecular weight of 1500000 to 2000000 g / mol and a degree of deacetylation of 99%. The silicone pad for skin reconstruction according to claim 1, wherein the adhesive layer has a tensile strength of 80 to 100 cN / cm 2 and an adhesive strength of 200 to 250 gmf / cm 2.

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