KR20170076223A - Hydrogel Capsule, Preparation Method Thereof and Cosmetic Composition Comprising The Same - Google Patents

Abstract

The present invention relates to a hydrogel capsule, a method for producing the same, and a cosmetic composition containing the same. More particularly, the present invention relates to a hydrogel capsule, and a cosmetic composition containing the cationic polymer and the anionic polymer, And a shell capable of forming a hydrogel in an aqueous system including a crosslinked polymer, a process for producing the same, and a cosmetic composition containing the same.
According to the present invention, the active ingredient trapped in the hydrogel capsule can maintain its stability even in the form of a solution in the presence of a surfactant or a salt. In addition, chitosan, hyaluronic acid, etc. forming a hydrogel are biocompatible and have an original skin improving effect, so that they can exhibit additional effects such as moisturizing and improving the hydrogel itself in addition to the effect of the active ingredient.

Description

TECHNICAL FIELD The present invention relates to a hydrogel capsule, a method for preparing the same, and a cosmetic composition containing the hydrogel capsule.

The present invention relates to a hydrogel capsule capable of effectively stabilizing an unstable active ingredient by covering the active ingredient, and exhibiting moisturizing and skin-improving effects of the hydrogel itself, a method for producing the same, and a cosmetic composition containing the same.

A typical characteristic of a hydrogel is that it can contain a large amount of water as a network structure of a hydrophilic polymer capable of swelling in water. It is mainly classified into two types: chemical crosslinking caused by covalent bonding and physical crosslinking due to physical interaction. Physically constructed network structures are not created by crosslinking points like covalent bonds but are created by physical bonding regions. Such non-covalent interactions include interactions such as dipole interactions, electrical interactions, hydrogen bonds, hydrophobic interactions, and the like.

The hydrogel is a hydrophilic polymer with a net structure. In the absence of moisture, the hydrogel is in the same state as the glass, but when absorbed and expanded, it becomes a soft and elastic gel. This is because the hydrogel is less biocompatible due to less mechanical friction with tissues around the living body. There have been various attempts to apply hydrogels to cosmetics as well as to applications such as drug delivery and tissue engineering.

For example, Korean Patent Registration No. 10-1191268 discloses a method of encapsulating nano-inorganic particles for ultraviolet screening agents into a hydrophilic polymer capsule capable of forming a hydrogel in a water system, thereby forming a thin hydrogel film of a polymer when applied to skin, The present invention proposes a capsule composition capable of preventing nano-inorganic particles from penetrating into the skin by holding nano-inorganic particles contained therein.

Korean Patent No. 10-1191268: Capsule Composition Containing Nano-Inorganic Particles for a UV-blocking Agent Using a Hydrogel-Capable Polymer and Method for Producing the Same

Disclosure of the Invention The object of the present invention is to provide a cosmetic composition which is capable of maintaining the structure and function of the active ingredient encapsulated therein without being affected by any environmental factors and at the same time being capable of exhibiting moisturizing and improving effects of the hydrogel itself Capsule, a process for producing the same, and a cosmetic composition containing the same.

In order to achieve the above object,

An active ingredient core,

A shell capable of forming a hydrogel in an aqueous medium, the polymer comprising a cationic polymer ionically bonded to the core and a polymer crosslinked with an amino acid and an anionic polymer,

The present invention provides a hydrogel capsule comprising:

Also,

An aqueous gel composition comprising: i) an oil phase comprising an oil and a surfactant; and ii) crosslinking in a w / o emulsion obtained by mixing an aqueous phase containing purified water, an active ingredient, a cationic polymer and an anionic polymer and an amino acid. Of the present invention.

Also,

There is provided a cosmetic composition comprising the above-mentioned hydrogel capsules.

According to the present invention, the active ingredient trapped in the hydrogel capsule can maintain its stability even in the form of a solution in the presence of a surfactant or a salt. In addition, chitosan, hyaluronic acid, etc. forming a hydrogel are biocompatible and have unique skin improving effect, so that they can exhibit additional effects such as moisturizing and improving the hydrogel itself in addition to the effect of the active ingredient.

1 is a flowchart of a method of manufacturing a hydrogel capsule according to an embodiment of the present invention.
FIG. 2 is a photograph showing the effect of increasing the skin cell energy production of the hydrogel capsule composition in Experimental Example 1. FIG.
FIG. 3 is a graph showing changes in skin moisture content according to the use of a test formulation containing a hydrogel capsule composition in Experimental Example 2. FIG.
FIG. 4 is a graph showing changes in water loss of the hard skin according to the use of the test formulation containing the hydrogel capsule composition in Experimental Example 3. FIG.

Hereinafter, the present invention will be described more specifically.

The hydrogel capsule of the present invention is a core-shell structure comprising a core containing an active ingredient and a polymer formed to surround the core, wherein the cationic polymer ion-bonded to each other and the polymer crosslinked with an amino acid by an anionic polymer And a shell capable of forming a hydrogel in the aqueous system.

The polymer contained in the shell becomes a hydrogel in the aqueous system to form a wall of the capsule, so that the core of the active ingredient can be stabilized from the external environment such as a surfactant and a physical force.

The active ingredient encapsulated in the hydrogel capsules is a physiologically active ingredient that can enter into the particles in various formulations of cosmetics. Most of the known physiologically active ingredients known to impart certain efficacy or effects to cosmetics can be used.

Particularly, unstable physiologically active materials can be physiologically active ingredients used in cosmetic compositions such as whitening agents, collagen synthesis promoters, wrinkle removers, skin barrier strengtheners, aging inhibitors, moisturizers and the like.

The active ingredient may be water-soluble as well as oil-soluble active ingredients. But are not limited to: Idebenone, Coenzyme Q10, tocopherol and its derivatives, vitamin C oil-soluble derivatives, retinol, retinal, retinoic acid, retinyl acetate, retinyl propionate, retinyl linoleate, Active active ingredients such as retinyl palmitate, bisretenamidomethylpentane, oleanolic acid, ursolic acid, diacetyl boldine, oiliness caviar extract, and soluble liquorice extract can be used . Examples of the water-soluble active ingredient include adenosine, arbutin, vitamin C and hydrophilic derivatives thereof, hydrophilic vitamins and derivatives thereof including vitamin B3, vitamin B5 and vitamin H; Kojic acid and its derivatives; Plant extracts including acetylglucosamine yeast extract, water-soluble caviar extract, Centella asiatica extract including madecassoside, and selenium aspartate; And various peptides obtained through cell culture are possible.

In this case, the active ingredient may be firstly stabilized with liposome, nanoparticle, nanobegycle, cyclodextrin capsule or the like. By this secondary encapsulation to form a dual multi-capsule structure, the stability of the water-soluble or oil-soluble active ingredient can be increased. For example, in the case of liposomes, since the liposome membrane is broken and returned to the micelles in an aqueous solution formulation containing various surfactants or various salts, there is a problem that stabilization of the active ingredient can not be expected. Therefore, It can be solved by forming multi-capsules with gel capsules.

The polymer forming the shell is a cationic polymer ionically bonded to each other and an anionic polymer crosslinked with an amino acid. Specifically, the cationic polymer and the anionic polymer form a network structure through ionic bonding, and they are covalently bonded to each other using an amino acid, so that the polymer can swell a large amount of water in the aqueous system.

The cationic polymer is a polymer having a cationic functional group and is selected from the group consisting of chitosan, polyquaternium-51, polyquaternium-52, polyquaternium-61, polyacrylate, polyvinylpyridine, polyvinylpyrrolidone, polyethyleneimine, poly Methyl methacrylate copolymer, styrene copolymer, and the like.

The anionic polymer is a polymer having an anionic functional group and may be hyaluronic acid, polyacrylate, monosaccharide, polysaccharide, cellulose, gelatin, alginic acid, sodium alginate, starch, oxidized starch, carboxymethylcellulose and the like.

The cationic polymer and the anionic polymer have a molecular weight of 10,000 to 1,000,000 Da.

The amino acid serves as a linker between a cationic polymer and an anionic polymer, and crosslinking can be formed by proper property of R group of amino acid, pI value and molecular weight.

Specifically, the R group should be non-polar aliphatic, polar non-negatively charged, and an amino acid having a molecular weight of 100 or more and a pI value of 5 to 10 is used. Specifically, it is at least one selected from the group consisting of proline, valine, leucine, isoleucine, methionine, serine, threonine, cysteine, asparagine, glutamine, lysine and histidine.

The hydrogel capsules of the present invention may have a particle size of 1 to 1000 mu m.

The hydrogel capsules of the present invention

a) preparing an oil phase comprising an oil and a surfactant;

b) preparing an aqueous phase comprising purified water, an active ingredient, a cationic polymer, an anionic polymer and an amino acid;

c) adding the water phase to the oil phase to form a w / o emulsion;

d) heating the w / o emulsion at 40 to 150 캜 to conduct polymerization and crosslinking reaction of the cationic polymer, anionic polymer and amino acid in the aqueous phase; And

e) recovering the hydrogel capsules from the w / o emulsion of d)

Lt; / RTI >

1 is a flowchart of a method of manufacturing a hydrogel capsule according to an embodiment of the present invention.

Will be described in detail below with reference to FIG.

First, an oil phase containing oil and a surfactant is prepared.

The oil used in the present invention is not particularly limited, and any oil conventionally used in this field is possible. Typically, hydrocarbon-based oils including polydecene and paraffin oil; Ester-based synthetic oils including cetyl ethylhexanoate, glyceryl trioctanoate, octyldodecyl myristate, isopropyl palmitate, isopropyl myristate and octyl palmitate; Silicone oil comprising cyclomethicone, dimethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, ethenyltrisiloxane, trisiloxane and cycloheptasiloxane; Animal oil; Vegetable oils including mango butter, shea butter, copoic acid butter, macadamia seed oil; Ethoxylated alkyl ester oils; Caprylic / capric triglyceride, ceramide, and mixtures thereof.

The surfactant is used for the formation of a W / O emulsion, and is not particularly limited in the present invention, and any kind of surfactant generally usable in this field can be used. The content thereof is 1 to 10% by weight based on the total weight of the oil phase.

Next, an aqueous phase containing purified water, an active ingredient, a cationic polymer, an anionic polymer and an amino acid is prepared.

The active ingredient, the cationic polymer, the anionic polymer, and the amino acid are mentioned above.

Specifically, the water phase contains 1 to 10% by weight of the active ingredient, 0.01 to 3% by weight of the cationic polymer, 0.01 to 3% by weight of the anionic polymer, 0.01 to 5% by weight of the amino acid and the balance water.

In addition, the water phase may comprise from 10 to 30% by weight of the polyol. The polyol contained in the aqueous phase may serve to maintain the osmotic pressure and increase the strength of the W / O emulsion produced in the subsequent step. Non-limiting examples of the polyol include glycerin, erythritol, propylene glycol, 1,3-butylene glycol, sorbitol, polyglycerin, propanediol, malitol glycerin, dipropylene glycol, 1,2- pentanediol, isoprene glycol, xylitol, polyethylene Glycols, isoprene glycol, xylitol, and combinations thereof.

The active ingredient contained in the water phase can be trapped within the liposome, nanoparticles, nanobegycles, or cyclodextrin capsules and can be primary stabilized. The stabilization method using liposomes, nanoparticles, nanobegycles, or cyclodextrin capsules is a well-known technique and therefore, a detailed description thereof will be omitted in the present invention.

The water phase is then added to the oil phase to form a W / O emulsion.

The mixing and emulsification process can be carried out in a vacuum emulsification tank capable of temperature control and stirring by a conventional method

And stirring and heating are performed as necessary.

The emulsions are carried out in a conventional mixer (for example, a homomixer) and are preferably prepared by performing stirring for 3 to 10 minutes at a speed of 2000 to 4000 rpm, preferably 3000 rpm.

Next, the w / o emulsion is heated to 40 to 150 ° C, and polymerization and crosslinking reaction of the cationic polymer, the anionic polymer and the amino acid are carried out in the aqueous phase.

And stirring is carried out at 40 to 150 ° C, preferably 65 to 75 ° C, for 1 to 3 hours at 5 to 15 rpm to induce polymerization and curing of the polymer without spontaneous initiator use.

Finally, the hydrogel capsules are recovered from the w / o emulsion.

For recovery of the hydrogel capsules, the oil present in the emulsion is dissolved in an organic solvent such as alcohol and centrifuged repeatedly to wash and remove.

The organic solvent is not limited as long as it can be mixed with water, but ethanol, methanol, isopropyl alcohol, acetone, tetrahydrofuran and the like can be used.

The recovered hydrocel capsules can be dispersed and stored in an aqueous solution.

The present invention provides a cosmetic composition in which a hydrogel capsule is contained in a cosmetic composition to stabilize an internal active material. The hydrogel capsules may be contained in an amount of 0.001 to 99.0% by weight, preferably 0.01 to 10.0% by weight, more preferably 0.1 to 3% by weight based on the total weight of the total cosmetic composition.

The hydrogel capsules of the present invention can be prepared in any form of cosmetic composition as known in the art and can be formulated into cosmetic compositions such as lotions, nutrition lotions, nutritional creams, massage creams, essences, packs, pastes, gels, creams, lotions, , Foundation, wax or spray.

In addition, in the cosmetic composition of each formulation, other components other than the above-mentioned cells can be arbitrarily selected and formulated according to the formulation of the other cosmetics, the purpose of use, and the like. In addition, the compositions of each formulation may contain various bases and additives necessary for formulation of the formulation, and may contain non-ionic surfactants, silicone polymers, extender pigments, flavorings, preservatives, But are not limited to, disinfectants, oxidative stabilizers, organic solvents, ionic or nonionic thickeners, plasticizers, antioxidants, free radical scavengers, opacifiers, stabilizers, emollients, silicones, A preservative, a surfactant, an anti-inflammatory agent, a substance P antagonist, a filler, a polymer, a propellant, a basicizing or acidifying agent, or a coloring agent.

When the formulation of the present invention is a paste, cream or gel, an animal oil, vegetable oil, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .

In the case where the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. Especially, in the case of a spray, a chlorofluorohydrocarbon, / Propane or dimethyl ether.

When the formulation of the present invention is a solution or an emulsion, a solvent, a dissolving agent or an emulsifying agent is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.

In the case where the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.

When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component is selected from aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, lanolin derivatives or ethoxylated glycerol fatty acid esters.

Hereinafter, preferred embodiments of the present invention will be described in order to facilitate understanding of the present invention. However, the following examples are provided to further understand the present invention, and the present invention is not limited by the examples.

Example  One

1.1 Biodegradable internal particles containing active ingredient ( Liposome )

The internal particles used in the actual experiments of the present invention were prepared by the following process.

Raw material name weight% Biologically active ingredient (retinol) 1.0 glycerin 30.0 Hydrogenated lecithin 5.0 1,2-hexanediol 2.0 Glicorse ping-pong feed 1.0 Caprylic / capric triglyceride 19.0 Purified water Balance Sum 100.0

The liposomes were firstly emulsified with a homogenizer (ROBO MIXER, PRIMIX Corporation, Japan) through the above-mentioned prescription, and then subjected to 1,000 bar and 3 pass with an ultrahigh pressure homogenizer (Microfluidizer, Microfluidics, USA).

1) The water phase (caprylic / capric triglyceride, biologically active ingredient (retinol)) and the upper part (purified water, glycerin, hydrogenated lecithin, 1,2-hexanediol, Lt; / RTI >

2) The oil phase was slowly poured into the water and homogeneously stirred through a ROBO MIXER.

3) The homogeneously stirred solution was cooled to 50 ° C and liposomes were formed on a MICROFLUIDIZER at 1,000 bar, 3 pass.

1.2 Preparation of W / O Emulsion Particles Containing Internal Particles

Raw material name weight% Liposome containing bio-active ingredient 10.0 Hyaluronic Acid 10.0 Polyquaternium-51 20.0 Proline 0.7 Cysteine 1.3 Purified water Balance Sum 100.0

Raw material name weight% Caprylic / capric triglyceride 90.0 Sorbitan olivate 10.0 Glyceryl stearate 10.0 Sum 100.0

The liposome-encapsulated hydrogel particles prepared in 1.1 above were prepared as an inner phase according to Table 2, and an outer phase containing a surfactant and an oil was prepared according to Table 3. Then, the inner and outer tracers were placed at the ratio of 1: 1, and the inner traces were slowly injected into the trauma, followed by homogeneous agitation through a ROBOMIXER.

1.3 Bioavailability The internal particles containing the active ingredient ( Liposome ) Hydro Manufacture of gel particles

The inner phase of the W / O emulsion formed in 1.2 above contains a mixture of a liposome, a polymeric anionic crosslinking agent forming a hydrogel, a polymeric cationic crosslinking agent and a linking amino acid, And the mixture was agitated at 75 ° C for 1 to 3 hours at 5 to 15 rpm to induce spontaneous polymer interconnection and curing. After the above reaction, the oil of the trauma was dissolved by using alcohol and centrifugation was repeatedly performed at least five times to remove the oil. The thus prepared final hydrogel particles can be dispersed and stored in an aqueous solution.

Experimental Example  One: Hydrogel  Of the capsule composition Skin cell  Confirm increased energy generation

The measuring instrument and the measurement conditions used in this experiment are as follows:

Measuring equipment:

- Two-photon microscope (DermaInspect; Jenlab)

- Chroma 640DCSPXR dichroic mirror (AHF analysentechnik AG, Tubingen, Germany)

- Blue emission filter (BG39, Schott AG, Mainz, Germany)

- 40x / 1.3 Plan-Apochromat oilimmersion objective (Zeiss, Gottingen, Germany)

Measuring conditions :

- Tunable infrared titanium-sapphire femtosecond-laser (710-920 nm tuning range; MaiTai; Spectra Physics, Darmstadt, Germany)

- excitation source: 730 nm (NAD (P) H), 890 nm (FAD).

The measurement was performed by the following steps according to the above measuring apparatus and measurement conditions.

1) After inoculating human fibroblasts or similar fibroblasts (CCD-986sk, HS68, Detroit 5116, etc.) to the bottom of the culture dish, penicillin (100 IU / mL), streptomycin (100 μg / mL ), DMEM (Dulbecco's Modified Eagle's Medium) medium containing 10% FBS (fetal bovine serum) or a medium having a growth rate equal to or higher than that of the medium was added and incubated at 37 ° C in an incubator containing 5% carbon dioxide.

2) Fibroblasts were plated on a 48-well plate at 5 × 10 ⁴ cells per well and cultured for 24 hours under cell culture conditions. The medium was discarded, washed with 10% PBS (phosphate buffered saline), and then incubated with the test solution and fresh medium for 24 hours.

3) Images were obtained by measuring NAD (P) H and FAD which are naturally emitted at 730 nm and 890 nm using a two-photon microscope. The results are shown in Fig.

The test solutions in this condition were as follows: control group, comparison group, and experimental group.

1) Control group: Purified water (negative control group)

2) Comparative group: Biologically active ingredient not encapsulated in hydrogel capsules (using this experiment retinol)

3) Experimental group: Active ingredient of biologically active substance encapsulated in hydrogel capsules

Referring to FIG. 2, in the case of the experimental group, it was confirmed that the cell power was improved when encapsulating the gel with the highest luminous intensity.

Experimental Example  2: Measurement of skin moisture change rate

The measuring instruments used in this experiment are as follows:

Measuring equipment:

- Corneometer (CM825, Courage + Khazaka electronic GmbH, Germany)

Subject selection:

- Adults who are between 20 and 49 years of age and who are satisfied with the selection criteria and who do not meet the exclusion criteria are selected.

Selection Criteria:

- Those who have written and signed a voluntary agreement to participate in the clinical trial,

- Healthy person who does not have acute and chronic physical illness including skin disease

- Those who can follow up during the test

By exclusion:

- Pregnant or lactating women and women who are pregnant

- A person who has used a skin external agent containing steroid for one month or more for the treatment of skin disease

- Those who have not passed six months after participating in the same test

- Persons with sensitive, irritable skin

- Those who have skin abnormalities such as dots, acne, capillary dilatation on the test site

- Those who used the same or similar cosmetics or medicines on the test site within 3 months before the start of the study

- Those who have undergone skin peeling or wrinkle removal procedures within 6 months before the start of the study

- Those who are deemed to be unsuitable for the examination by the State Expert

Number of subjects:

- More than 20 persons were selected for the criteria that did not apply to the criteria for selection of the subjects. The final number of participants was 22 persons.

Test Methods :

- The test product of Table 4 below was applied to the test site (1.5 cm X 1.5 cm) selected for the forearm using a micro pipette at 4 pcs of ² μl / cm ² each

- Before the application of the product, 2 weeks after application, 4 weeks after application, total 3 times, and the average value was obtained by using 3 values excluding the maximum value and the minimum value.

- Wipe the measurement area with kimwipes and measure

- The skin moisture was measured using the Corneometer (CM825, Courage and Khazaka Electronic Co., Germany)

The Corneometer is made by measuring the static load capacitance of the current passing through the probe in contact with the skin. The water content and the static load capacity are proportional to each other, and the higher the water content, the higher the measured value, and the measurement factor is the arbitrary unit (A.U.). The measurement results are shown in Fig.

Test formulations:

For the above clinical test, creams were prepared according to the composition shown in Table 4 below and used in the experiment.

ingredient Content (% by weight) The hydrogel dispersion solution of Table 5 5.0 Pro-type glycerin monostearate 2.0 Cetearyl alcohol 2.0 Stearic acid 1.5 Polysorbate 60 1.5 Sorbitan stearate 0.6 Hydrogenated polyisobutene 1.0 Squalane 3.0 Mineral oil 5.0 Cyclomethicone 5.0 Dimethicone 1.0 Tocopheryl acetate 0.5 glycerin 5.0 Betaine 3.0 Triethanolamine 1.0 Xanthan gum 0.05 incense Suitable amount antiseptic Suitable amount Pigment Suitable amount Distilled water Balance Sum 100.00

ingredient Content (% by weight) The hydrogel capsules prepared in Example 1 5.0 Butylene glycol 5.0 glycerin 10.0 1,2-hexanediol 2.0 Distilled water Balance Sum 100

As shown in FIG. 3, skin moisture content was increased with use of the test formulation, and skin moisturizing effect of the cosmetic composition including the hydrogel capsules was confirmed.

Experimental Example  3: Hard skin  Water loss ( TEWL ) Measurement of rate of change

Measuring equipment:

- Tewameter (TM300, Courage + Khazaka electronic GmbH, Germany)

Subject selection:

- Adult women between 20 and 49 years of age who satisfy the selection criteria and who do not meet the exclusion criteria.

Selection Criteria:

- Those who have written and signed a voluntary agreement to participate in the clinical trial,

- Healthy person who does not have acute and chronic physical illness including skin disease

- Those who can follow up during the test

By exclusion:

- Pregnant or lactating women and women who are pregnant

- A person who has used a skin external agent containing steroid for one month or more for the treatment of skin disease

- Those who have not passed six months after participating in the same test

- Persons with sensitive, irritable skin

- Those who have skin abnormalities such as dots, acne, capillary dilatation on the test site

- Those who used the same or similar cosmetics or medicines on the test site within 3 months before the start of the study

- Those who have undergone skin peeling or wrinkle removal procedures within 6 months before the start of the study

- Those who are deemed to be unsuitable for the examination by the State Expert

Number of subjects:

- Twenty or more persons were selected for the criteria that did not apply to the selection criteria of the subjects, and the number of final participants was 22.

Test Methods :

- The test product of Table 4 was applied to the test site (1.5 cm X 1.5 cm) selected for the forearm using a micro pipette at 4 pcs of ² μl / cm ² each

- Before the application of the product, 2 weeks after the application, 4 weeks after the application, and 3 times after the application, the mean value was calculated using the three values excluding the maximum value and the minimum value

- Wipe the measurement area with kimwipes and measure

- Skin moisture was measured using a Tewameter (TM300, Courage + Khazaka electronic GmbH, Germany)

Tewameters are made up of water vapor that evaporates through the skin barrier through a probe that contacts the skin. Barrier damage and water evaporation are proportional to each other, so the higher the damage to the skin barrier, the higher the measured value and the measurement factor is g / m ² h. The measurement results are shown in Fig.

As shown in FIG. 5, the skin moisture loss due to the use of the test formulation was decreased, and the skin moisturizing effect of the cosmetic composition including the hydrogel capsules was confirmed.

Claims (12)

An active ingredient core,
A shell capable of forming a hydrogel in an aqueous medium, the polymer being formed by surrounding the core and comprising a cationic polymer ion-bonded to each other and an anionic polymer cross-linked with an amino acid,
≪ / RTI > The composition according to claim 1, wherein the active ingredient is
A hydrogel capsule characterized by being a water-soluble active ingredient or an oil-soluble active ingredient. The method of claim 1, wherein the cationic polymer comprises
Chitosan, polyquaternium-51, polyquaternium-52, polyquaternium-61, polyacrylate, polyvinylpyridine, polyvinylpyrrolidone, polyethyleneimine, polymethylmethacrylate copolymer, styrene copolymer and the like Wherein the hydrogel encapsulant is one selected from the group consisting of a mixture of water and an organic solvent. The positive photosensitive composition according to claim 1, wherein the anionic polymer is
Wherein the hydrogel capsule is one selected from the group consisting of hyaluronic acid, polyacrylate, monosaccharide, polysaccharide, cellulose, gelatin, alginic acid, sodium alginate, starch, oxidized starch, carboxymethylcellulose and mixtures thereof. The method of claim 1, wherein the amino acid is
Wherein the hydrogel capsule is one selected from the group consisting of proline, valine, leucine, isoleucine, methionine, serine, threonine, cysteine, asparagine, glutamine, lysine, histidine and mixtures thereof. 6. The pharmaceutical composition according to any one of claims 1 to 5,
A liposome, a nanoparticle, a nano-beadlet, or a cyclodextrin capsule, and is firstly stabilized. 7. The pharmaceutical composition according to any one of claims 1 to 6, wherein the hydrogel capsule
Wherein the diameter of the hydrogel capsule is 1 to 1,000 mu m. An aqueous gel composition comprising: i) an oil phase comprising an oil and a surfactant; and ii) crosslinking in a w / o emulsion obtained by mixing an aqueous phase containing purified water, an active ingredient, a cationic polymer and an anionic polymer and an amino acid, ≪ / RTI > 9. The method of claim 8,
a) preparing an oil phase comprising an oil and a surfactant;
b) preparing an aqueous phase comprising purified water, an active ingredient, a cationic polymer, an anionic polymer and an amino acid;
c) adding the water phase to the oil phase to form a w / o emulsion;
d) heating the w / o emulsion at 40 to 150 캜 to conduct polymerization and crosslinking reaction of the cationic polymer, anionic polymer and amino acid in the aqueous phase; And
e) recovering the hydrogel capsules from the w / o emulsion of d)
≪ / RTI > 10. The composition according to claim 8 or 9, wherein the active ingredient is
Liposomes, nanoparticles, nano-beads, or cyclodextrin capsules, and is firstly stabilized. 10. The method according to claim 8 or 9,
Further comprising a polyol. ≪ RTI ID = 0.0 > 21. < / RTI > A cosmetic composition comprising the hydrogel capsule according to any one of claims 1 to 7.

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