KR20170033925A

KR20170033925A - Spray compositions having antiviral efficacy and antibacterial agent

Info

Publication number: KR20170033925A
Application number: KR1020150131378A
Authority: KR
Inventors: 송경진
Original assignee: 송경진
Priority date: 2015-09-17
Filing date: 2015-09-17
Publication date: 2017-03-28

Abstract

Disclosed is an antiviral and antibacterial spray composition made by mixing a main ingredient with the 1-10% content of a povidone-iodine solution and an additive with the 1-3% content of hydrocortisone, and mixing and diluting 30-150 parts by weight of the mixture to the 100 parts by weight of the main ingredient, and 100-100,000 parts by weight of purified water to 100 parts by weight of the mixture. Also, an antiviral and antibacterial spray composition made by mixing a main ingredient with the 1-10% content of benzalkonium chloride and an additive with the 1-3% content of hydrocortisone, and mixing and diluting 30-150 parts by weight of the mixture to the 100 parts by weight of the main ingredient, and 100-100,000 parts by weight of purified water to 100 parts by weight of the mixture. The composition having povidone-iodine and benzalkonium chloride with antivirus and antiviral useful for bacterial respiratory diseases as active ingredients can increase treatment effects.

Description

[0001] Spray compositions containing antiviral efficacy and antibacterial agents [

The present invention relates to an antiviral and bacterial spray composition comprising povidone iodine or benzalkonium chloride as a useful ingredient, and more particularly, to a spray composition for antiviral and bacterial spores containing povidone iodine or benzalkonium chloride as an effective ingredient, The present invention relates to a spray composition for antivirals and bacteria, which has excellent antimicrobial activity, antiviral activity, deodorant activity and antibacterial activity against respiratory diseases by adding hydrocortisone having a high activity against bacteria.

The major viruses that cause acute respiratory infections include influenza virus (INFV) types A and B; Parainfluenza virus (PIV) types 1, 2 and 3; Respiratory syncytial virus (RSV) types A and B; And adenovirus (ADV); (SARSCoV), which causes SARS, and the avian influenza virus (avian A / H5N1), which is infectious to humans as well as birds, and the Middle East Respiratory Syndrome (MERS), which recently spread rapidly in Korea.

Viruses causing these respiratory diseases not only have very high infectivity, but also represent a variety of clinical manifestations from asymptomatic infection to severe infection to death. Clinical symptoms due to each virus vary from common cold symptoms to pneumonia, usually within a few days, but coughing and fatigue can last for more than 2 weeks, and abdominal pain, vomiting and seizures are rare. The most common complication is pneumonia, and there are deaths due to aggravation of the underlying disease and complications in the elderly or chronic patients.

MERS, a middle-east respiratory syndrome that recently broke out in Korea, is a serious acute respiratory illness caused by a new variant coronavirus (MERS-CoV) infection, and has been on the Arabian Peninsula in the Middle East since 2012. By 2015, More than 400 people have died. It is less infectious than SARS caused by another variant coronavirus, but the mortality rate is 30-40% higher than SARS (about 9.6%).

It is common to have symptoms of respiratory symptoms such as fever, cough and dyspnea more than 38 degrees on the occasion of an onset, and it is common to have headache, chills, Sore throat, runny nose, myalgia with vomiting, abdominal pain, diarrhea, anorexia, such as digestive symptoms may be seen. Most patients with mellus cause symptoms such as severe acute lower respiratory illness (pneumonia), but some have no symptoms or only mild cold symptoms, and when symptoms become severe, various complications such as respiratory failure, septic shock, multiple organ failure &Lt; / RTI > Unlike SARS, it is often accompanied by acute renal failure due to impaired renal function. In particular, complications are common in people with chronic diseases such as diabetes or kidney failure, or those with impaired immune function.

In the case of respiratory viruses such as the respiratory syndrome of the Middle East, respiratory viruses are known to exhibit persistent infection patterns throughout the year due to the general nature of the virus during the winter season. In the case of MERS, the infectious disease is a droplet infection that is spread by body fluids such as saliva and runny nose It was announced. In other words, when an infected person sneezes, a droplet containing a high-concentration virus through the mouth and nose is released. Then, during the process of brushing the droplet by hand, it can be spread to others through shaking hands and skin contact. Or intimate contact, may be transmitted even in the process of bronchoscopy.

These middle-respiratory syndromes are known to have a risk of infection if they are within 2 to 3 m of the infected person, although the particles with microorganisms such as bacteria float in the air and have lower spreading power than airborne infections. People who were not in the same room as the infected person are also infected and may suspect air infections. The World Health Organization (WHO) recommended on 1 June 2015 that "Airborne Precautions" were required for MERS.

However, most viral respiratory diseases, including acute bacterial pneumonia, pulmonary tuberculosis, and bronchitis, including mers, have not been developed with effective vaccines except some, There is no special treatment except for the treatment of water supply and stabilization, the use of antipyretic drugs, antibiotics for prevention of secondary infection, and so on.

In other words, faster and more accurate diagnosis of the causative virus is crucial for early prevention of disease spread and effective treatment of patients, but viral respiratory infections are clinically caused by a virus Because it is difficult to identify and distinguish from bacterial respiratory infection, there are many difficulties in accurate diagnosis.

On the other hand, various methods have been used for the diagnosis of viruses causing acute respiratory infections. In this method, a method for detecting viruses by virus inoculation into cells susceptible to viruses, It is known as the most reliable method, but a long time is required for the diagnosis. In addition, antigen-capture is a method of identifying a virus antigen by using an antibody against a virus, that is, a capsid or an envelope of a virus, ELISA and IFA. However, this method has a disadvantage in that it can not be applied to the diagnosis of acute disease because of the disadvantage that the time for detecting the antigen in the patient sample is limited to the acute phase with clinical symptoms.

In recent years, in order to overcome these limitations, a molecular biological method for detecting a virus gene has been applied, and a gene diagnosis method has been widely used as an advantage of shortening the time required for diagnosis.

In the meantime, the method of diagnosing respiratory viruses has been shortened compared with the past, but in cases where there is no appropriate treatment such as vaccine, the proper isolation procedure has not been performed due to the inability to confirm the correct propagation path, It caused severe social disorder and adversely affects the economy as well as serious disruption of medical blindness due to distrust of the medical field.

The Applicant has completed a composition for antiviral use which is effective for effective treatment and inhibition of respiratory viruses.

Patent No. 10-1341353, page 2, claim 1, figure 2. Patent No. 10-1133877, page 2, claim 1, figure 1.

SUMMARY OF THE INVENTION The present invention has been made in order to solve the problems of the prior art as described above, and it is an object of the present invention to provide a vaccine for the prevention and treatment of AIDS (Acquired Immunodeficiency Syndrome), Spanish influenza, Asian influenza (H2N3 H3N1 H3N2) Including the eight major infectious diseases including H5N1, H1N1, Ebola Virus, Congo measles, and Severe Acute Respiratory Syndrome, Antiviral components against respiratory viruses such as scorpion virus (MERS-CoV), bacterial pneumonia, pulmonary tuberculosis, and antibacterial components against bronchial and other bacterial respiratory diseases, povidone iodine or benzyl chloride The present invention is to provide an antiviral and bacterial spray composition using the active ingredient as a useful component.

In addition, the present invention provides an antiviral composition comprising povidone-iodine or benzalkonium chloride as a useful ingredient in a spray method for spray-aspirating a patient, By spraying or spraying the composition, the composition medicines deeply breathe into the lungs of the patient, reaching all the lungs in the deep part of the bronchus as well as the antibiotics and bacteria To provide a spray composition.

The present invention also provides an antiviral and bacterial spray composition capable of preventing and preventing the spread of the respiratory virus caused by respiratory virus caused by MERS-CoV, which is referred to as Mers.

It is another object of the present invention to provide an antiviral and bacterial spray composition capable of inhibiting the spread of bacterial respiratory diseases such as bacterial pneumonia, pulmonary tuberculosis and bronchitis, and enabling efficient and rapid treatment of the disease.

In order to achieve the above object, the antiviral spray and bacterial composition according to the preferred embodiment of the present invention is characterized in that it comprises a supporter having a content of 1 to 10% of povidone iodine solution and an additive having a content of hydrocortisone of 1 to 3% And 100 to 100,000 parts by weight of purified water is mixed and diluted with 100 parts by weight of the main component and 30 to 150 parts by weight of the mixture.

A spray composition for antiviral and germs according to another preferred embodiment of the present invention is prepared by mixing a suspension having a content of 1 to 10% of benzalkonium chloride and an additive having a content of 1 to 3% of hydrocortisone, And 100 to 100,000 parts by weight of purified water is mixed and diluted with 100 parts by weight of the mixture.

The antiviral and bacterial spray compositions according to the present invention can be used for the treatment of eight common infectious diseases including Acquired Immunodeficiency Syndrome, Spanish Flu, Asian Flu (H2N3 H3N1 H3N2), Hong Kong Influenza (H3N8 H5N1), Novel Influenza respiratory viruses such as Mers-CoV, which is called merse, including the swine-origin influenza A (H1N1), Ebola virus, Congo measles, SARS (Severe Acute Respiratory Syndrome) , Bacterial pneumonia, and bacterial respiratory diseases such as pulmonary tuberculosis and bronchitis. The composition of the present invention has an advantage of enhancing the therapeutic effect by using povidone iodine and benzalkonium chloride as useful components.

In addition, the present invention allows a drug containing povidone iodine and benzalkonium chloride as a main component to be easily sucked through the mouth and nose, and the inhaled drug reaches the lung vesicles in the deep part through the lungs, It is possible to efficiently treat a patient while minimizing the psychological anxiety experienced by the patient, thereby providing a high therapeutic effect.

In addition, since the present invention can be mass-produced in a short time, rapid response to infectious pathogens through rapid diffusion is possible, and thus it is expected that an effective medical prevention system against infectious respiratory virus can be constructed.

The features and advantages of the present invention will become more apparent from the following detailed description based on the accompanying drawings. Prior to that, terms and words used in the present specification and claims should not be construed in a conventional and dictionary sense, and the inventor may properly define the concept of the term in order to best explain its invention It should be construed as meaning and concept consistent with the technical idea of the present invention.

Hereinafter, the antiviral and bacterial spray compositions of the present invention will be described in detail. However, specific descriptions of known functions and configurations will be omitted in order to avoid obscuring the gist of the present invention.

The spray composition for antiviral and germs according to the first embodiment of the present invention comprises povidone iodine as a main ingredient and hydrocortisone to prepare a spray composition containing a povidone iodine solution having a content of 1 to 10% and a hydrocortisone 1 to 3% by weight of an additive, and 30 to 150 parts by weight of the additive is mixed with 100 parts by weight of the main ingredient, and 100 to 100 parts by weight of the mixture is diluted with 100 to 100,000 parts by weight of purified water.

First, povidone iodine used as a mainstay in the embodiment of the present invention is not widely used in general households, but it is still used for disinfecting medical staff and wiping a surgical site of a patient in a hospital operating room.

Povidone iodine is known to have more bactericidal or viral types and to be more effective than alcohol, which is the main ingredient of sterilized tablets.

In the in vitro test results, it was confirmed that the results of the in vitro test were as follows: a SAR coronavirus belonging to coronavirus such as Mervis virus, adenovirus as a cold virus, Norovirus causing acute diarrhea, avian flu virus and rhinovirus causing respiratory diseases such as acute rhinitis, It has been known that it has shown a wide range of antiviral effects through in vitro experiments on measles, mumps, flu, human immunodeficiency virus (HIV) and super bacteria (MRSA, Methicillin Resistant S. aureus) Studies on in vitro viral viral effects on Ebola virus have confirmed that ebola virus has been removed after 15 seconds of application of povidone iodine (4%).

First, povidone iodine, a useful ingredient of the antiviral and bacterial spray composition of the present invention, is as follows.

Povidone iodine Standard code Active ingredient code product name manufacturer Volume
657400260

216201CLQ
Becetin solution
(10% povidone iodine solution)
Sung Kwang Pharmaceutical
100 mg

Uses of Sekwang Pharmaceutical Beesetin solution (povidone iodine solution 10%) in the above (Table 1) will be described as follows. Excerpt from Poviclean Wash (Medicine Dictionary, Pharmacy Information Source)

Bessentin solution (10% povidone iodine solution) in the above (Table 1) is used for disinfection of torn wounds, burns, wounds and disinfection of infected skin surface. After wetting infected area with water, I will. Apply the foam for about 3 minutes and wash it off. Use 2 to 3 times a day or as directed by a doctor.

Povidone Iodine Bessetin Solution (Povidone Iodine Solution 10%) Standard code Active ingredient code product name manufacturer Volume
657400390

216206clq
Povicreen cleaning
Sung Kwang Pharmaceutical
75 mg

The povidone cleaning solution of Sung Kwang Pharm (Table 2) was prepared by using 75 mg of povidone iodine as a yellowish brown liquid.

(Excerpted from Poviclean Wash for Medicine)

1, purpose of use

a. 10% liquid (absorbent cotton swab) (absorbent cotton swab) - Disinfection of torn wounds, burns and wounds, disinfection of ulcers, disinfection of abscesses, disinfection of infected skin surface and disinfection of surgical sites and disinfection of injections and catheters

b. 7.5% liquid - Disinfection of wound, burn, wound, disinfection and infection Disinfection of skin surface

c. (7.5%) - Disinfection of the hands and arms of the operator and disinfection of the surgical site

d. Aerosol agent - disinfection of wound, burn, wound, disinfection and infection Disinfection of skin surface and disinfection of surgical site

e. Ointment - Disinfection of torn wounds, burns, wound, pressure ulcer and ulcer, disinfection of infections and infection Disinfection of skin surface and sterilization of injections and catheters

2. Dosage Dosage

a. Liquid agent 10% (adsorption cotton swab) (absorbent cotton swab) -1 days Put the appropriate amount on the affected part several times.

b. Liquid 7.5% - After infecting the infected area with water, take enough of this medicine to bubble out. Apply the foam for about 3 minutes and wash it off. Use 2 to 3 times a day or as directed by your doctor.

c. Cleaning liquid, tax amount 7.5%

1) Sterilize the hands and arms of the operator: Take about 5 mL of this and rub the hands and arms thoroughly for about 5 minutes to remove the bubbles. Then thoroughly rinse with running water.

2) Sterilization of the surgical site: Apply this medicine directly or use an appropriate amount of rubbing thoroughly to remove the bubbles, then wipe with sterile gauze.

d. Aerosol Day -1 - 1 - several times An appropriate amount is sprayed at a distance of 25 cm from the skin to cover the affected area. Shake well before use, leave to dry until film formation.

e, Ointment agent - Apply the appropriate amount to the affected part several times a day to the affected part. Cover with dressing or bandages as needed.

Meanwhile, the present invention adds hydrocortisone with povidone iodine as a main component. The hydrocortisone proposed in the present invention is a kind of glucocorticoid biosynthesized in adrenal cortex, which is produced by 11? -Hydroxysteroid dehydrogenase in cortisol. It is widely used as an anti-inflammatory and anti-allergic agent mainly for rheumatoid arthritis and other inflammation.

Hydrocortisone Standard code Active ingredient code product name manufacturer Volume
653005000

170901CLT
Lotty Care Echizen Lotion 1%
(Hydrocortisone)
Korea Pharma Corporation
10 mg

1% of the lactic acid erythema lotion in the above (Table 3) is used as analgesic, analgesic, astringent, anti-inflammatory agent in the institutional system, and 1 g of hydrocortisone as a white lotion agent (Poviclean Wash) (excerpt from Drug Dictionary, Pharmacokinetic Information Sources), and it is said that it has an efficacy effect on eczema dermatitis, itchy skin, insect bite, and the appropriate amount is applied to the affected part for several times.

Hydrocortisone Standard code Active ingredient code product name manufacturer Volume
653005010

170902CLT
Lotty Care Echizen Lotion 2.5%
(Hydrocortisone)
Korea Pharma Corporation
25 mg

As in (3) above, it is used as a medicinal product for analgesic, analgesic, astringent, anti-inflammatory agent in the above-mentioned (Table 4) It is said that it has the effect of hydrocortisone 2.5g, eczema dermatitis, itchy skin, insect bite and efficacy, and the appropriate amount is applied to the affected part several times, depending on the symptom. Wash] (drug dictionary, drug information source) excerpt)

An example of an antiviral composition comprising povidone iodine according to the present invention as an effective component is 1 ml of a 10% content of a povidone iodine solution of Sung Kwang Pharmaceutical Co., Ltd., which is the drug standard code 657400260 of Table 1 and the main ingredient code 216201CLQ, and 1 ml of a drug standard code 653005000 And 1% of the additive of 1% of lacticeche echinacea lotion of Korea Pharma Co., Ltd. [Table 3] which is the main ingredient code 170901CLT.

Another example of an antiviral composition comprising povidone-iodine according to the present invention as a useful component includes 1 ml of a povidoclean cleansing agent manufactured by Sung Kwang Pharmaceutical Co., Ltd., which is the pharmaceutical standard code 657400390 of Table 2, the main ingredient code 216206 clq, ] Of the drug standard code 653005010 and the ingredient code 170902CLT of LotteCare Echinacea Lotion 2.5% (hydrocortisone) of Korea Pharma Co., Ltd. can be mixed.

The antiviral and bacterial spray compositions containing the povidone-iodine according to the present invention, which is constituted as described above, are filled into a navel or a spray device or a diffusing device and injected into the oral cavity or the nasal cavity of the patient, The composition of the present invention containing povidone iodine as a useful component can obtain an antiviral effect against viruses.

The spray composition for antiviral and bacterium according to the second embodiment of the present invention is prepared by adding benzalkonium chloride as a main ingredient and hydrocortisone to form a spray composition of benzalkonium chloride 1 to 10 %, And an additive having a content of hydrocortisone of 1 to 3%, wherein 30 to 150 parts by weight of the additive is mixed with 100 parts by weight of the main ingredient, 100 parts by weight of purified water of 100 to 100,000 parts by weight By weight of the total weight of the composition.

Benzalkonium chloride (Benzalkoniumchloride) is one of the most widely known cationic activators, an alkylbenzyldimethylammonium chloride mixture of various even alkyl rings in which the primary amine is methylated to form dimethylalkylamine followed by benzyl chloride to quaternary ammonium salt .

In other words, benzalkonium chloride is a nitrogen cationic surfactant belonging to a quaternary ammonium salt. It is a mixture of alkylbenzyldimethylammonium chloride which is not soluble in water but is easily dissolved in ethanol and acetone, and the aqueous solution is easy to handle. It has weakly alkaline chemical properties. The color is colorless or pale yellow and has a bubbley and bitter taste when shaking the solution.

These benzalkonium chlorides are widely used for skin disinfectants, preservatives, preservatives, hand cleaners, eyedrops, antibacterial towels, floor cleaners and surgical tool disinfectants. Unlike hydrogen peroxide or ethanol disinfectants, they can be disinfected There is an advantage.

These benzalkonium chlorides are used extensively and are widely used for skin disinfectants, preservatives, preservatives, hand cleaners, nasal cleaners, eyelashes, eye drops, sanitary towels, antibacterial towels, floor cleaners, surgical tool disinfectants, herpes, , Used as a fungicide.

Unlike hydrogen peroxide or ethanol disinfectants, benzalkonium chloride has the advantage of disinfecting the injured area without stimulation. Benzalkonium chloride has been used safely for decades as a disinfectant for children's wounds.

Hydrocortisone is a kind of glucocorticoid biosynthesized in the adrenal cortex, which is produced by 11? -Hydroxysteroid dehydrogenase in cortisol. It is widely used as an anti-inflammatory and anti-allergic agent mainly for rheumatoid arthritis and other inflammation.

The hydrocortisone in the embodiment of the present invention is the same as the hydrocortisone in the first embodiment described above, and a detailed description thereof will be omitted.

Domestic products containing benzylzinc chloride are 0.11, 10% Greeneyl solution of HanYu Pharmaceutical and 10% Zenhei pesticide solution of Samnam Chemical Co., Of magic chromium.

The benzalkonium chloride used in the present invention may be 100 ml of the undiluted solution, but 0.1 to 10% of the product sold by the above company may be used.

The benzalkonium chloride may be used in a mixture of 30 to 150 parts by weight of hydrocortisone based on 100 parts by weight of water, and may be diluted with purified water to spray the oral and pulp parts of the patient.

In this embodiment, it is proposed that 100 to 100,000 parts by weight of purified water is mixed and diluted based on 100 parts by weight of the mixture of benzalkonium chloride and hydrocortisone.

As described above, the spray composition for antivirals and bacteria according to the second embodiment of the present invention in which the mixture of the mixture of benzalkonium chloride and hydrocortisone and the purified water are mixed has a similar use method and operation effect of the first embodiment described above And thus a detailed description thereof will be omitted.

The antiviral and bacterial spray compositions containing the benzalkonium chloride according to the present invention, which is constituted as described above, are injected into a navel or a spray device or a diffuser and injected into the patient's oral cavity or nasal cavity, It is possible to obtain the antiviral effect against the virus by the composition of the present invention containing the benzenesulfonium chloride as a useful component.

It is to be understood that the present invention is not limited to the disclosed embodiment and that various changes and modifications may be made without departing from the spirit and scope of the present invention as set forth in the appended claims. It is obvious to those who have knowledge. It is therefore intended that such variations and modifications fall within the scope of the appended claims.

Claims

A povidone-iodine solution having a content of 1 to 10% and an additive having a content of 1 to 3% of hydrocortisone, wherein 30 to 150 parts by weight of hydrocortisone as an additive are mixed with 100 parts by weight of the povidone iodine solution And 100 to 100,000 parts by weight of purified water is mixed and diluted with 100 parts by weight of the mixture.

A mixture of 100 parts by weight of benzalkonium chloride and 30 to 150 parts by weight of hydrocortisone, which is an additive, is mixed with an additive having a content of 1 to 10% of benzalkonium chloride and an additive having a content of 1 to 3% of hydrocortisone And 100 to 100,000 parts by weight of purified water is mixed and diluted with 100 parts by weight of the mixture.