KR20170027737A - O-알킬-벤질리덴구아니딘 유도체 및 미스폴딩된 단백질의 축적 관련 장애의 치료를 위한 치료 용도 - Google Patents

O-알킬-벤질리덴구아니딘 유도체 및 미스폴딩된 단백질의 축적 관련 장애의 치료를 위한 치료 용도 Download PDF

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KR20170027737A
KR20170027737A KR1020167036779A KR20167036779A KR20170027737A KR 20170027737 A KR20170027737 A KR 20170027737A KR 1020167036779 A KR1020167036779 A KR 1020167036779A KR 20167036779 A KR20167036779 A KR 20167036779A KR 20170027737 A KR20170027737 A KR 20170027737A
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alkyl
compound
disease
formula
aryl
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필리프 구에닷
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인플렉티스 바이오사이언스
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    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • C07C281/16—Compounds containing any of the groups, e.g. aminoguanidine
    • C07C281/18—Compounds containing any of the groups, e.g. aminoguanidine the other nitrogen atom being further doubly-bound to a carbon atom, e.g. guanylhydrazones
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    • C07D295/08—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms
    • C07D295/084—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/088—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly bound oxygen or sulfur atoms with the ring nitrogen atoms and the oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain
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    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/10—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms
    • C07D295/104—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings
    • C07D295/108—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by doubly bound oxygen or sulphur atoms with the ring nitrogen atoms and the doubly bound oxygen or sulfur atoms attached to the same carbon chain, which is not interrupted by carbocyclic rings to an acyclic saturated chain

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  • Chemical & Material Sciences (AREA)
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  • Child & Adolescent Psychology (AREA)
  • Hospice & Palliative Care (AREA)
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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
KR1020167036779A 2014-07-02 2015-07-02 O-알킬-벤질리덴구아니딘 유도체 및 미스폴딩된 단백질의 축적 관련 장애의 치료를 위한 치료 용도 Ceased KR20170027737A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP14306076 2014-07-02
EP14306076.2 2014-07-02
PCT/EP2015/065162 WO2016001390A1 (en) 2014-07-02 2015-07-02 O-alkyl-benzylideneguanidine derivatives and therapeutic use for the treatment of disorders associated an accumulation of misfolded proteins

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KR20170027737A true KR20170027737A (ko) 2017-03-10

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KR1020167036779A Ceased KR20170027737A (ko) 2014-07-02 2015-07-02 O-알킬-벤질리덴구아니딘 유도체 및 미스폴딩된 단백질의 축적 관련 장애의 치료를 위한 치료 용도

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US (2) US10544093B2 (https=)
EP (1) EP3164391B1 (https=)
JP (1) JP6621815B2 (https=)
KR (1) KR20170027737A (https=)
CN (1) CN106488907B (https=)
AU (1) AU2015282901B2 (https=)
CA (1) CA2951186A1 (https=)
DK (1) DK3164391T3 (https=)
ES (1) ES2749657T3 (https=)
HR (1) HRP20191731T1 (https=)
HU (1) HUE046660T2 (https=)
IL (1) IL249485B (https=)
MX (1) MX2016016491A (https=)
PL (1) PL3164391T3 (https=)
PT (1) PT3164391T (https=)
RS (1) RS59400B1 (https=)
RU (1) RU2706002C2 (https=)
SI (1) SI3164391T1 (https=)
WO (1) WO2016001390A1 (https=)

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KR102572217B1 (ko) 2015-04-08 2023-08-28 유나이티드 킹덤 리서치 앤드 이노베이션 포스파타제 선택적 및 비 선택적 포스파타제 억제제의 선별 방법
US20180230105A1 (en) 2017-01-13 2018-08-16 Regents Of The University Of Minnesota Therapeutic compounds
US20210177814A1 (en) 2018-05-09 2021-06-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Use of guanabenz or derivates thereof for the treatment of type i ifn-dependent pathologies
WO2020012339A1 (en) * 2018-07-09 2020-01-16 Glaxosmithkline Intellectual Property Development Limited Chemical compounds
WO2024105168A1 (en) * 2022-11-18 2024-05-23 Inflectis Bioscience Novel combinations useful for the treatments of als
US20240293343A1 (en) 2023-02-13 2024-09-05 Inflectis Bioscience Benzylideneaminoguanidine derivatives as NR2B-selective NMDA receptor antagonists and their therapeutic applications

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US3982020A (en) 1970-03-17 1976-09-21 Sandoz, Inc. Substituted benzylidene hydrazines for treating hyperglycemia, obesity and inflammation
NZ207394A (en) 1983-03-08 1987-03-06 Commw Serum Lab Commission Detecting or determining sequence of amino acids
AU645799B2 (en) * 1990-05-07 1994-01-27 Novartis Ag Hydrazones
SE9604348D0 (sv) * 1996-11-26 1996-11-26 Wapharm Ab Användning av hydroxyguanidiner
GB0019357D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel phenyl guanidines
GB0019359D0 (en) * 2000-08-07 2000-09-27 Melacure Therapeutics Ab Novel guanidines
US7071211B2 (en) 2002-09-27 2006-07-04 Bausch & Lomb Inc. Small organic molecules that increase the activity of gelatinase a in ocular cells
BRPI0414622A (pt) 2003-09-25 2006-11-07 Acadia Pharm Inc métodos de identificação de compostos, método de seleção de composto, métodos de tratamento de dores agudas e crÈnicas, compostos e métodos de tratamento de dores neuropáticas ou inflamatórias
CN1875271A (zh) * 2003-09-25 2006-12-06 阿卡蒂亚药品公司 用神经肽ff受体2激动剂治疗神经痛
EP1908464A1 (en) * 2006-10-04 2008-04-09 Centre National De La Recherche Scientifique (Cnrs) Use of chlorine guanabenz derivatives for treating polyglutamine expansion associated diseases
GB0623381D0 (en) * 2006-11-23 2007-01-03 Acure Pharma Ab Use of a compound as VEGF inhibitor
WO2011061340A1 (en) 2009-11-23 2011-05-26 INSERM (Institut National de la Santé et de la Recherche Médicale) Inhibitors of the pp1/gadd34 complex for the treatment of a condition requiring an immunosuppressive activity
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WO2014138298A1 (en) 2013-03-05 2014-09-12 University Of Chicago Treatment of demyelinating disorders

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DK3164391T3 (da) 2019-10-14
ES2749657T3 (es) 2020-03-23
US20200102269A1 (en) 2020-04-02
US10544093B2 (en) 2020-01-28
RU2016151411A (ru) 2018-06-26
RU2016151411A3 (https=) 2018-11-16
PT3164391T (pt) 2019-10-29
JP2017522370A (ja) 2017-08-10
HUE046660T2 (hu) 2020-03-30
JP6621815B2 (ja) 2019-12-18
AU2015282901B2 (en) 2019-01-17
HRP20191731T1 (hr) 2019-12-13
CN106488907A (zh) 2017-03-08
AU2015282901A1 (en) 2017-01-05
SI3164391T1 (sl) 2019-12-31
EP3164391A1 (en) 2017-05-10
RS59400B1 (sr) 2019-11-29
MX2016016491A (es) 2017-08-02
WO2016001390A1 (en) 2016-01-07
US11084783B2 (en) 2021-08-10
CA2951186A1 (en) 2016-01-07
IL249485B (en) 2018-07-31
EP3164391B1 (en) 2019-07-31
RU2706002C2 (ru) 2019-11-13
PL3164391T3 (pl) 2019-12-31
IL249485A0 (en) 2017-02-28
CN106488907B (zh) 2021-01-29

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