KR20170019897A - Chemical reaction sensing apparatus based on optics - Google Patents

Chemical reaction sensing apparatus based on optics Download PDF

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KR20170019897A
KR20170019897A KR1020150114389A KR20150114389A KR20170019897A KR 20170019897 A KR20170019897 A KR 20170019897A KR 1020150114389 A KR1020150114389 A KR 1020150114389A KR 20150114389 A KR20150114389 A KR 20150114389A KR 20170019897 A KR20170019897 A KR 20170019897A
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pattern
substrate
image
target material
deformable structure
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KR1020150114389A
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Korean (ko)
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전상범
지창현
유현지
선우경
박준희
양세정
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이화여자대학교 산학협력단
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Publication of KR20170019897A publication Critical patent/KR20170019897A/en

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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/16—Measuring arrangements characterised by the use of optical techniques for measuring the deformation in a solid, e.g. optical strain gauge
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01B—MEASURING LENGTH, THICKNESS OR SIMILAR LINEAR DIMENSIONS; MEASURING ANGLES; MEASURING AREAS; MEASURING IRREGULARITIES OF SURFACES OR CONTOURS
    • G01B11/00—Measuring arrangements characterised by the use of optical techniques
    • G01B11/24—Measuring arrangements characterised by the use of optical techniques for measuring contours or curvatures
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/0002—Inspection of images, e.g. flaw detection
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T7/00—Image analysis
    • G06T7/60—Analysis of geometric attributes
    • G06T7/64—Analysis of geometric attributes of convexity or concavity
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10004—Still image; Photographic image
    • G—PHYSICS
    • G06—COMPUTING; CALCULATING OR COUNTING
    • G06T—IMAGE DATA PROCESSING OR GENERATION, IN GENERAL
    • G06T2207/00—Indexing scheme for image analysis or image enhancement
    • G06T2207/10—Image acquisition modality
    • G06T2207/10028—Range image; Depth image; 3D point clouds

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  • Physics & Mathematics (AREA)
  • General Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
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  • Immunology (AREA)
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Abstract

According to an embodiment of the present invention, a chemical reaction sensing apparatus based on an optical system comprises: a substrate having a variable structure coated with a probe material which is mechanically deformed upon reacting with a target material; an optical projection unit which projects an optical signal having an image onto the substrate; and an optical image unit which senses the image generated on the substrate by the optical signal having the image and projected from the optical projection unit when the probe material reacts with the target material to cause the mechanical deformation of the variable structure, measuring a degree of deformation of the variable structure. According to an embodiment of the present invention, the chemical reaction sensing apparatus is able to measure the reaction between the probe material coated on the variable structure such as a membrane and the target material based on an optical system; thereby simplifying the structure of a conventional apparatus while enhancing a sensing accuracy when compared to the conventional apparatus.

Description

[0001] The present invention relates to an optical system-

An optical system based chemical reaction sensing apparatus is disclosed. More particularly, the present invention relates to an optical system-based chemical reaction detection apparatus capable of measuring the reaction between a target material and a probe substance applied to a membrane based on an optical system, thereby simplifying the structure of the apparatus and improving the accuracy of detection .

A transistor-based biosensor having a structure including a transistor among the sensors that detect biomolecules using an electrical signal has been mainly used. This has been achieved by using a semiconductor process. Since the electrical signal conversion is fast and the IC and the MEMS can be easily combined with each other, much research has been conducted in the past.

US Pat. No. 4,238,757 is the original patent for measuring biological reactions using FETs. This is for a biosensor that measures the antigen-antibody reaction by current as a change in the semiconductor inversion layer due to a change in the surface charge density, and is about a protein in a biomolecule.

On the other hand, according to a lab on a chip (Biomolecular detection with a thin membrane transducer) published on April 1, 2008, a thin film transducer is used to detect protein by hybridization and DNA hybridization A sensor capable of sensing such nucleic acid-based biomolecule reactions is disclosed.

According to this, due to surface reaction, the thin film is deformed due to the specific intermolecular reaction occurring on the thin film made with PDMS.

However, in the conventional sensor, since the degree of the reaction between the probe and the target material is detected through the change of the capacitance, the electrode may be provided on the thin film and the electricity may be applied to the thin film.

Accordingly, it is required to develop a reaction sensor of a new structure which can more accurately detect the reaction degree than the conventional method, but can simplify the structure.

It is an object of the present invention to provide an apparatus and method for measuring a reaction between a target material and a probe material applied to a deformable structure such as a membrane based on an optical system to simplify the structure of the apparatus and improve the accuracy of detection Based chemical reaction detection device capable of detecting the presence of a chemical reaction.

It is another object of the present invention to provide an optical system-based chemical reaction sensing apparatus which can apply a camera module of a smart device as a configuration of an image optical unit, .

An optical system based chemical reaction sensing apparatus according to an embodiment of the present invention includes a substrate having a deformable structure coated with a probe material on which a mechanical deformation is generated upon reaction with a target material; A projection optical unit for projecting an optical signal having an image onto the substrate; And a controller configured to detect an image generated on the substrate by an optical signal having the image projected from the projection optical unit when the probe material reacts with the target material and mechanical deformation occurs in the deformable structure, According to this configuration, the reaction between the target material and the probe material applied to the deformable structure such as the membrane can be measured based on the optical system, so that the structure of the device can be measured Simplification can improve detection accuracy as well.

According to one aspect, the projection optics can form a pattern that projects an optical signal having the image onto the substrate to optically measure the displacement on the substrate.

According to one aspect of the present invention, the image optical unit may detect the degree of bending of the pattern by checking displacement of points forming the pattern when the probe material reacts with the target material to cause deformation in the deformable structure, The deformation amount can be measured.

According to one aspect of the present invention, it is possible to determine the presence or progress of a bottle of the person providing the target material according to the amount of deformation of the deformable structure according to the degree of bending of the pattern.

According to one aspect, the pattern may be a pattern of a grid type, an alignment pattern of dots, a motional pattern, or a pattern of parallel lines.

According to one aspect, the deformable structure may be a membrane or cantilever capable of mechanical deformation.

According to one aspect, the image optical system may include a camera module of a portable smart device.

According to one aspect, between the substrate and the image optical unit, there is a ratio of an optical signal having the image provided from the projection optical unit to the substrate or an optical signal corresponding to an image provided to the image optical unit from the substrate, At least one optical lens for adjusting the accuracy can be arranged.

According to one aspect of the present invention, a plurality of the deformable structures are disposed on the substrate, and a reaction in which the image optical portion is formed in the plurality of deformable structures simultaneously can be detected after reacting the target material with each of the deformable structures.

Meanwhile, an optical system based chemical reaction sensing apparatus according to an embodiment of the present invention includes a deformable structure coated with a probe material that is mechanically deformed upon reaction with a target material, and a pattern for optically measuring displacement is formed Board; And an image sensing unit for sensing a degree of bending of the pattern by checking a displacement of points forming the pattern when the probe material reacts with the target material and mechanical deformation is generated in the deformable structure, And an optical portion.

According to one aspect of the present invention, it is possible to determine the presence or progress of a bottle of the person providing the target material according to the amount of deformation of the deformable structure according to the degree of bending of the pattern.

According to one aspect, the pattern may be a pattern of a grid type, an alignment pattern of dots, a motional pattern, or a pattern of parallel lines.

According to one aspect, the deformable structure may be a membrane or cantilever capable of mechanical deformation.

According to one aspect, the image optical system may include a camera module of a portable smart device.

According to the embodiment of the present invention, since the reaction between the target material and the probe material applied to the membrane can be measured based on the optical system, the structure of the apparatus can be simplified and the accuracy of detection can be improved.

According to the embodiment of the present invention, the camera module of the smart device can be applied as one configuration of the image optical unit, so that the reaction test can be performed regardless of the place, compared with the conventional one.

FIG. 1 is a diagram illustrating a configuration of an optical system-based chemical reaction sensing apparatus according to an embodiment of the present invention.
Fig. 2 is a schematic view of Fig.
FIG. 3 is a view showing a state before the probe material of the membrane of the substrate shown in FIG. 1 reacts with the target material.
FIG. 4 is a view showing a mechanical deformation of the membrane when the probe material shown in FIG. 3 reacts with a target material.
5 is an image obtained by the image optical section shown in Fig.
FIG. 6 is a view schematically showing a configuration of an optical system-based chemical reaction sensing apparatus according to another embodiment of the present invention.

Hereinafter, configurations and applications according to embodiments of the present invention will be described in detail with reference to the accompanying drawings. DETAILED DESCRIPTION OF THE INVENTION The following description is one of many aspects of the claimed invention and the following description forms part of a detailed description of the present invention.

In the following description, well-known functions or constructions are not described in detail for the sake of clarity and conciseness.

FIG. 2 is a schematic view of FIG. 1, and FIG. 3 is a cross-sectional view of the probe of the membrane of the substrate shown in FIG. 1; FIG. FIG. 4 is a view showing that a mechanical deformation occurs in a membrane when the probe material shown in FIG. 3 reacts with a target material, and FIG. 5 is a cross- . ≪ / RTI >

As schematically shown in FIGS. 1 and 2, the optical system-based chemical reaction sensing apparatus 100 according to an embodiment of the present invention is a system in which a mechanical deformation occurs in reaction with a target material 101 such as blood A projection optical unit 120 for projecting an optical signal having an image onto the substrate 110 and a projection optical system 120 for projecting the probe material 117 on the substrate 110. The substrate 110 has a deformable structure 115 on which a probe material 117 is applied, The image generated on the substrate 110 is detected by the optical signal having the image projected from the projection optical unit 120 when the deformable structure 115 is mechanically deformed by the reaction with the target material 101, And an image optical unit 150 for measuring a deformation amount of the structure 115. [

With such a configuration, it is possible to determine the presence or progress of a disease or the like of a person who provided the target material 101. [ As described above, in the prior art, the electrical wiring has to be provided on the substrate 110 and the deformation amount is measured using the electrostatic capacity method. In this embodiment, however, the deformation amount can be accurately measured only by image sensing without electrical wiring, As a result, the structure can be simplified and the ease of carrying can be ensured as will be described later.

As shown in FIG. 2, the substrate 110 of the present embodiment has a structure in which a variable structure 115 is disposed on a substrate 110 having a chip on which circuits are formed. Here, the deformable structure 115 refers to a mechanical deformable structure when a mechanical force is applied from the outside, and in this embodiment, the membrane 115 can be applied. However, the type of the deformable structure 115 is not limited to this, and for example, a cantilever or the like can be applied.

The membrane 115 can be coated with the probe material 117, which is mechanically deformed when reacting with the target material 101, as shown in Fig. Each of the probe materials 117 reacts with the target material 101 individually to cause deformation as shown in FIG. 4, whereby the probe material 117 is uniformly applied to the deformable structure 115, that is, the membrane 115 ) Can also cause mechanical deformation. Here, the probe material 117 may be an exothermic material provided as a biopolymer material that inhibits protein interaction through three-dimensional bonding with a target material 101 in the form of a single, double helix DNA or RNA. However, the present invention is not limited thereto.

Although it is shown in the drawing that the membrane 115 is provided as a single unit on the substrate 110, it is obvious that the membrane 115 is not limited thereto and a plurality of membranes 115 may be provided on the substrate 110. In this case, for example, another target material 101 may be reacted with each of the membranes 115, and an image optical unit 150 to be described later may acquire an image of a reaction generated at a plurality of the membranes 115 at a time So that the efficiency of reaction detection can be improved.

On the other hand, the optical system of the present embodiment includes, as described above, a projection optical unit 120 that provides an image on a substrate 110, and a projection optical unit 120 that detects an image on the substrate 110, And an image optical unit 150.

First, the projection optical unit 120 of the present embodiment projects an optical signal having an image onto the substrate 110, as shown in Figs. 1 and 2. Through this, a grid-type pattern 111 (see the image of FIG. 5) can be formed on the substrate 110. In other words, a square-shaped grid pattern 111 having a regular pattern can be formed on the substrate 110. However, the pattern is not limited thereto, and it is applicable if it is a pattern for optically measuring the displacement on the substrate 110. For example, an alignment pattern consisting of dots in a pattern, a motif pattern or a pattern made of parallel lines can be applied.

This projection optical section 120 is connected to the projector controller 125 by a connection line and the projector controller 125 is connected to the computer 130 as shown in Figure 1 so that the image of the projection optical section 120 It is possible to control the projection of the optical signal. The size of the grid pattern 111 and the like can be precisely controlled.

1 and 2, the projection optical unit 120 can be placed at an inclined position from the substrate 110, and a structure such as a beam splitter 140 is interposed between the projection optical unit 120 and the vertical upper portion of the substrate 110 An optical signal having an image projected from the projection optical unit 120 can reach the top surface of the substrate 110. [

3 and 4, when the target material 101 reacts with the probe material 117 on the membrane 115, a mechanical deformation occurs in the probe material 117, A mechanical deformation occurs in the metal plate 115. That is, deformation such as bending occurs. Then, the lattice-type pattern 111 caused by the optical signal having the image provided from the projection optical unit 120 may also be deformed as shown in Fig. That is, the degree of reaction between the target material 101 and the probe material 117 is revealed as a change in the pattern 111 of the lattice type.

Therefore, the deformation amount of the deformable structure 115 can be measured by detecting the change of the displacement of the points forming the grid-type pattern 111 and the like. In this embodiment, the deformation amount of the deformable structure 115 is measured by the image optical unit 150.

1 and 2, the image optics section 150 of this embodiment is arranged on the top of the substrate 110 to measure the change of the grating type pattern 111 formed on the substrate 110. [ In other words, the image optics part 150 checks the displacement of the points forming the grid-type pattern 111 when the probe material 117 reacts with the target material 101 and deformation occurs in the membrane 115 The degree of bending of the grid-type pattern can be sensed, and the deformation amount of the deformable structure 115 can be accurately measured.

The computer 130 connected to the image optics 150 may then determine the presence or absence of a bottle of the person providing the target material 101 according to the amount of deformation of the deformable structure 115 depending on the degree of bending of the grid- And furthermore, when it is judged that there is a disease, it is possible to judge the progress of the disease.

The connection line connecting the image optical unit 150 and the computer 130 may include a frame grabber card 160 for capturing a frame, but the present invention is not limited thereto.

The image optical unit 150 of the present embodiment may include a camera module provided in a portable smart device, such as a smart phone or a smart pad, in one configuration. The camera module included in the smart device may be connected to the computer through a wired or wireless system to transmit an image obtained from the substrate 110. The presence or absence of the bottle according to the measurement of the deformation amount of the deformable structure 115, Can be determined.

As described above, since the camera module of the smart device can be applied to the image optical unit 150, it is possible to perform the reaction test on the target material 101 regardless of the place.

Although not shown, at least one optical lens (not shown) may be provided between the substrate 110 and the image optical unit 150. Such an optical lens may have a magnification or an accuracy of an optical signal corresponding to an image provided to the substrate 110 from the projection optical unit 120 or an optical signal corresponding to an image provided to the image optical unit 150 from the substrate 110 Thereby improving the reliability of the reaction test.

As described above, according to the embodiment of the present invention, the reaction between the target material 101 and the probe material 117 applied to the membrane 115 can be measured based on the optical system, Of course, there is an advantage of improving the accuracy of detection.

In addition, since the camera module of the smart device can be applied as the configuration of the image optical unit 150, there is an advantage that the reaction test can be performed regardless of the place.

Hereinafter, an optical system based chemical reaction sensing apparatus according to another embodiment of the present invention will be described, but the description of the substantially same components as those of the chemical reaction sensing apparatus of the above embodiment will be omitted.

FIG. 6 is a view schematically showing a configuration of an optical system-based chemical reaction sensing apparatus according to another embodiment of the present invention.

As shown in the figure, the optical system-based chemical reaction sensing apparatus 200 according to another embodiment of the present invention includes a deformable structure 215 on which a probe material is mechanically deformed when reacting with a target material A substrate 210 on which a lattice-type pattern is formed, a substrate 210 on which a lattice-type pattern is formed, and a lattice- And an image optical unit 250 that detects the degree of bending of the deformable structure 215 and measures the amount of deformation of the deformable structure 215.

In other words, in the case of the substrate 210 of the present embodiment, unlike the case where the substrate 110 (see FIG. 1) of the above-described embodiment receives an optical signal having an image from the projection optical unit 120 and a grid type pattern is formed, A grid-type pattern may be directly formed on one configuration of the substrate 215 or the substrate 210 on which it is supported.

Thus, the image optics 250 may detect the degree of bending of the grid-type pattern by checking the displacement of the points forming the grid-type pattern when the probe material reacts with the target material and deformation occurs in the membrane 215 So that the amount of deformation of the deformable structure 215 can be accurately measured. According to the amount of deformation of the deformable structure 215, the presence or absence of a person who provided the target material can be determined. Further, if it is determined that there is a disease, the degree of progress of the disease can be determined.

In the case of this embodiment, since the reaction inspection can be performed using the camera module of the smart device while carrying the unit constituting the substrate 210, the efficiency of the reaction inspection can be improved.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit and scope of the invention. Accordingly, such modifications or variations are intended to fall within the scope of the appended claims.

100: Optical system based chemical reaction detection device
110: substrate
115: Variable structure
117: probe substance
120: projection optical part
130: Computer
150: image optical part

Claims (14)

A substrate having a deformable structure applied with a probe material on which a mechanical deformation occurs upon reaction with a target material;
A projection optical unit for projecting an optical signal having an image onto the substrate; And
And an image generated on the substrate by the optical signal having the image projected from the projection optical unit when the probe material reacts with the target material and mechanical deformation occurs in the deformable structure, An image optical part for measuring a deformation amount;
Based chemical reaction detection device.
The method according to claim 1,
Wherein the projection optics projects a light signal having the image onto the substrate to form a pattern for optically measuring displacement on the substrate.
3. The method of claim 2,
Wherein the image optic part measures displacement of points forming the pattern when the probe material reacts with the target material to generate a deformation in the deformable structure and detects a degree of bending of the pattern to measure a deformation amount of the deformable structure Optical system based chemical reaction sensing device.
The method of claim 3,
Based on the amount of deformation of the deformable structure according to the degree of bending of the pattern, the presence or the degree of progress of the bottle of the person providing the target material can be determined.
3. The method of claim 2,
Wherein the pattern is a pattern of a grid type pattern, an alignment pattern of dots, a motional source pattern, or a parallel line pattern.
The method according to claim 1,
Wherein the deformable structure is a membrane or cantilever capable of mechanical deformation.
The method according to claim 1,
Wherein the imaging optical system comprises a camera module of a portable smart device.
The method according to claim 1,
Between the substrate and the image optics, there is provided an optical system for adjusting the magnification or accuracy of an optical signal having the image provided to the substrate from the projection optics or an optical signal corresponding to an image provided to the image optics from the substrate An optical system based chemical reaction sensing device in which at least one optical lens is disposed.
The method according to claim 1,
Wherein a plurality of the deformable structures are disposed on the substrate, and each of the deformable structures reacts with a target material, and at the same time, the image optical unit senses a reaction occurring in the plurality of deformable structures.
A substrate having a deformable structure coated with a probe material on which a mechanical deformation occurs in reaction with a target material, the substrate having a pattern for optically measuring displacement; And
And an image optics for measuring the amount of deformation of the deformable structure by detecting a degree of bending of the pattern by checking a displacement of points forming the pattern when the probe material reacts with the target material and mechanical deformation is generated in the deformable structure, part;
Based chemical reaction detection device.
11. The method of claim 10,
Based on the amount of deformation of the deformable structure according to the degree of bending of the pattern, the presence or the degree of progress of the bottle of the person providing the target material can be determined.
11. The method of claim 10,
Wherein the pattern is a pattern of a grid type pattern, an alignment pattern of dots, a motional source pattern, or a parallel line pattern.
11. The method of claim 10,
Wherein the deformable structure is a membrane or cantilever capable of mechanical deformation.
11. The method of claim 10,
Wherein the imaging optical system comprises a camera module of a portable smart device.
KR1020150114389A 2015-08-13 2015-08-13 Chemical reaction sensing apparatus based on optics KR20170019897A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110823116A (en) * 2019-10-25 2020-02-21 同济大学 Image-based building component deformation measurement method

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110823116A (en) * 2019-10-25 2020-02-21 同济大学 Image-based building component deformation measurement method

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