KR20170002249A - Antioxidative composition comprising Hexanedioic acid - Google Patents
Antioxidative composition comprising Hexanedioic acid Download PDFInfo
- Publication number
- KR20170002249A KR20170002249A KR1020150092560A KR20150092560A KR20170002249A KR 20170002249 A KR20170002249 A KR 20170002249A KR 1020150092560 A KR1020150092560 A KR 1020150092560A KR 20150092560 A KR20150092560 A KR 20150092560A KR 20170002249 A KR20170002249 A KR 20170002249A
- Authority
- KR
- South Korea
- Prior art keywords
- composition
- active oxygen
- hexanedioic acid
- antioxidant
- prevention
- Prior art date
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Images
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
- A61K31/225—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2200/00—Function of food ingredients
- A23V2200/30—Foods, ingredients or supplements having a functional effect on health
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Emergency Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Mycology (AREA)
- Nutrition Science (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Fodder In General (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The present invention relates to an antioxidative composition comprising hexanedioic acid as an active ingredient. In the past, there has been no report on the antioxidative activity of hexanedioic acid. In the present invention, hexanedioic acid has antioxidant activity against active oxygen, and it can be used as an antioxidant composition for preventing oxidation.
Specifically, the present invention relates to a pharmaceutical composition for antioxidation for eliminating, inhibiting or preventing active oxygen containing hexanedioic acid as an active ingredient, a composition for health food for antioxidation for the elimination, inhibition or prevention of active oxygen, An antioxidant composition for antioxidation for elimination, inhibition or prevention of oxygen, an antioxidant feed composition for eliminating, inhibiting or preventing active oxygen, a quasi-quasi-antioxidant composition for the prevention, inhibition or prevention of active oxygen, Hexanedioic acid can be used as an antioxidant composition for antioxidant for the elimination, inhibition or prevention of active oxygen by effectively eliminating and inhibiting active oxygen.
Description
The present invention relates to an antioxidative composition comprising hexanedioic acid as an active ingredient. More specifically, the present invention relates to an antioxidative composition comprising hexanedioic acid as an active ingredient, An antioxidant pharmaceutical composition, an antioxidant health food composition for eliminating, inhibiting or preventing active oxygen, an antioxidant animal pharmaceutical composition for eliminating, inhibiting or preventing active oxygen, an antioxidant feed for eliminating, inhibiting or preventing active oxygen Composition for preventing or inhibiting active oxygen, quasi-quasi-antioxidant composition for antioxidation for inhibiting or preventing active oxygen, and composition for preventing or preserving food, wherein hexanedioic acid effectively scavenges and inhibits active oxygen, It is useful as an antioxidant composition for antioxidant for eliminating, inhibiting or preventing active oxygen.
Recently, as the population increases and the life expectancy increases, it is rapidly entering an aging society, and chronic diseases such as chronic skin diseases, hypertension, diabetes, cancer and metabolic diseases are increasing rapidly with the increase of environmental pollution to be. Accordingly, various dietary habits, diet, disease prevention, health food and therapeutic drugs are being researched and developed to prevent diseases.
However, therapeutic drugs that block the initial outbreak of the disease early, or restore the disease to pre-disease levels and innovative supplements for disease prevention are rare. In this respect, the in vivo prophylactic approach at the early stage of disease development is presented as a solution for disease prevention. That is, the elimination of reactive oxygen at the cellular level, which is an early stage of disease development, can reduce the risk of disease development by preventing and preventing damage and deformation of cells induced by active oxygen.
Oxygen is a necessary substance for human survival and the proportion of oxygen in our body is about 65% or more. Oxygen is an important element for humans and animals to survive, but not all oxygen is beneficial and beneficial to the human body. In other words, the modified oxygen that can harm our body is active oxygen. Reactive oxygen species are all kinds of deformed oxygen that damage cells. That is, hydrogen peroxide (H 2 O 2 ), superoxide ion (O 2 - ) and hydroxyl radical (OH - ) are typical reactive oxygen species.
In particular, radicals in active oxygen are atoms, ions, and molecules that contain unpaired electrons. In general, electrons tend to react with other molecules if they are solitary due to their tendency to exist in pairs. Therefore, in most cases the radicals are unstable, so molecular structures that stabilize radicals stabilize free radicals even though the molecules are small.
In addition, active oxygen is unstable and tends to forcibly remove electrons from neighboring substances. In particular, excess oxidized ions and hydroxyl radicals stabilize by depriving electrons from DNA and proteins present in the environment. In this process, excess oxide ions and hydroxyl radicals are reduced (accept electrons), and surrounding substances oxidize (give electrons). Thus, if the radical is stabilized by reacting with a third substance before it reacts with proteins, carbohydrates, fats and other essential biomaterials, it can reduce damage and damage by radicals at the cellular level.
In particular, the oxygen that enters the body during the breathing process is converted into active oxygen, which is oxidatively strong in various metabolic processes through the oxidation process, and attacks the biotissue and damages the cells. Damage at the cellular level by reactive oxygen species damages cell membranes, DNA, and organelles, leading to protein deformation and dysfunction. These abnormalities block or inhibit the action of useful circulating proteins that cause normal physiological functions, causing the disease to occur at the cellular level and at the molecular level, and the function of the cells and tissues is deteriorated Or mutated to change its function. However, active oxygen is not only a bad influence in the body. In the process of biological defense to remove pathogens and foreign substances in vivo, active oxygen is generated in a large amount, and the strong germicidal action of these agents protects the human body from pathogens.
It is known that various diseases of modern people are related to active oxygen. In particular, the increase of active oxygen induced in vivo acts as a trigger of various diseases. Particularly, such active oxygen causes various chronic diseases and refractory diseases by inducing aging, inflammation, ulcer, cancer, arteriosclerosis, diabetes, stroke, myocardial infarction, nephritis, atopy, dementia and Parkinson disease through oxidative stress, This leads to a reduction in life expectancy and to social costs for the treatment of diseases.
Therefore, in order to avoid such diseases, it is necessary to eliminate a large amount of reactive oxygen generated in the body at the cellular level and the molecular level. Antioxidants such as vitamin E, vitamin C, carotenoids, flavonoids and other antioxidants have great effects on disease prevention and health promotion. These substances are generally called antioxidants (antioxidants, oxidation-induced substances caused by active oxygen).
Under these circumstances, the present inventor has endeavored to research and develop new antioxidants, and confirmed that "hexanedioic acid" has active oxygen scavenging activity or antioxidant activity that inhibits active oxygen, thereby completing the present invention .
It is an object of the present invention to provide a pharmaceutical composition for antioxidation for eliminating, inhibiting or preventing active oxygen containing hexanedioic acid as an active ingredient.
It is another object of the present invention to provide a health food composition for antioxidation for eliminating, inhibiting or preventing active oxygen containing hexanedioic acid as an active ingredient.
Another object of the present invention is to provide an antioxidant feed composition for eliminating, inhibiting or preventing active oxygen containing hexane diol acid (Hexanedioic acid) as an active ingredient.
Another object of the present invention is to provide an animal pharmaceutical composition for antioxidation for eliminating, inhibiting or preventing active oxygen containing hexanedioic acid as an active ingredient.
Still another object of the present invention is to provide a quasi-drug composition for prevention of eradication, inhibition or prevention of active oxygen containing hexanedioic acid as an active ingredient.
It is still another object of the present invention to provide a composition for preserving or preventing oxidation of food containing hexanedioic acid as an active ingredient.
In order to achieve the above object, the present invention provides a pharmaceutical composition for antioxidation for eliminating, inhibiting or preventing active oxygen containing hexanedioic acid as an active ingredient.
The term "hexanedioic acid" used in the present invention is also called "adipic acid" or "hexane-1,6-dioic acid" and is white crystals having the chemical structure C 6 H 10 O 4 and the molar mass ) Is 146.14 g / mole. In the present invention, the antioxidant activity was measured after dissolving hexanedioic acid with ethanol or distilled water to prepare solutions at different concentrations. In one embodiment of the present invention, it was confirmed that the hexanedioic acid had an antioxidative activity against active oxygen (FIGS. 1 and 2).
The term "antioxidant" as used herein refers to the ability of active oxygen to be cleared or inhibited by active oxygen by an antioxidant, a physiologically active substance or a known chemical, and "prevention" It means all acts that suppress. In one embodiment of the present invention, it was confirmed that Hexanedioic acid strongly scavenges active oxygen and has an antioxidative or antioxidative effect against active oxygen through DPPH assay (FIGS. 1 and 2).
The hexanedioic acid of the present invention is not limited thereto, but may be a synthetic material obtained by chemical synthesis or a substance derived from an animal, a plant and an insect. The hexanedioic acid can be obtained by an extraction method or a separation and purification method derived from common synthetic methods, animals, plants and insects known in the art. The method for extracting the above extract is not limited thereto. Preferably, the extraction method may be organic solvent extraction, hot water extraction, hot water extraction, cold extraction, steam reflux extraction, reflux cooling extraction, ultrasonic extraction or freeze- Conventional methods may be suitably used, but are not limited thereto.
In the present invention, the solvent used for extracting, extracting, or preparing the hexanedioic acid may be water or an organic solvent commonly used in the art, including, but not limited to, water, hexane, chloroform, ethyl Acetone, ether, acetonitrile, acetonitrile, an alcohol having 1 to 6 carbon atoms, or a mixed solvent thereof may be used, and more preferably, hexane, chloroform, methanol, ethanol, propanol, butanol, isopropanol, Benzene, dichloromethane or a mixed solvent thereof may be used.
The pharmaceutical composition of the present invention may include, but is not limited to, a pharmaceutically acceptable carrier. Examples of carriers, excipients and diluents that can be included in the pharmaceutical composition of the present invention include dextrose, sorbitol, mannitol, xylitol, erythritol, maltitol, starch, acacia rubber, alginate, calcium silicate, cellulose, methylcellulose, microcrystalline cellulose, poly Vinyl pyrrolidone, water, methylhydroxybenzoate, propylhydroxybenzoate, and mineral oil. Compositions comprising a pharmaceutically acceptable carrier can be of various oral or parenteral formulations. In the case of formulation, it can be prepared using diluents or excipients such as fillers, extenders, binders, humectants, disintegrants, surfactants and the like which are usually used. Solid formulations for oral administration may include tablet pills, powders, granules, capsules, and the like, which may contain one or more excipients, such as starch, calcium carbonate, sucrose, or lactose lactose, gelatin, and the like. In addition to simple excipients, lubricants such as magnesium stearate, talc, and the like may also be used. Liquid preparations for oral administration include suspensions, solutions, emulsions, syrups and the like. Various excipients such as wetting agents, sweeteners, fragrances, preservatives and the like may be included in addition to water and liquid paraffin, which are simple diluents commonly used. have. Formulations for parenteral administration may include sterile aqueous solutions, non-aqueous solutions, suspensions, amino acids, emulsions, lyophilized formulations, and suppositories. Examples of the non-aqueous solvent and the suspending agent include propylene glycol, polyethylene glycol, vegetable oil such as olive oil, and injectable ester such as ethyl oleate. Examples of the suppository base include witepsol, macrogol, tween 61, cacao paper, laurin, glycerogelatin and the like.
In addition, the pharmaceutical composition of the present invention may be in the form of tablets, pills, powders, granules, capsules, sustained release formulations, suspensions, suspensions, solutions, emulsions, injections, Wherein the formulation is selected from the group consisting of a patch, a film, a mouthwash, a coating agent, a patch, an inhalant, a syrup, an emulsion, a gel, an ointment, an eye drop, a sterilized aqueous solution, , And the form of the formulation that can be produced by the above example is not limited.
The dosage form of the pharmaceutical composition of the present invention is not particularly limited and may be varied depending on the degree of absorption, body weight, age, sex, health condition, diet, administration time, administration method, excretion rate, have. The pharmaceutical composition of the present invention is prepared in consideration of an effective dose range, and the formulated unit dosage form can be prepared by using a specialized dosage regimen according to the judgment of the expert and the needs of the individual, Lt; / RTI >
In another aspect, the present invention provides an antioxidant health food composition for eliminating, inhibiting or preventing active oxygen containing hexanedioic acid as an active ingredient. The health food composition may be achieved by strongly scavenging active oxygen and having an antioxidative or antioxidant effect on active oxygen, as described above.
When the composition of the present invention is used as an additive for food, the composition may be added as it is or may be used together with other health food or ingredients thereof, and may be suitably used according to a conventional method. The mixing amount of the active ingredient can be suitably determined according to the purpose of use, and the amount of the food composition of the present invention is not particularly limited.
The food of the present invention is not particularly limited and examples of the health food to which the composition can be added include meat, sausage, bread, chocolate, candy, snack, confectionery, pizza, ramen, other noodles, gum, Dairy products, various soups, beverages, tea, juice, drinks, alcoholic beverages and vitamin complexes, and may include foods used as food for animals, which may include all health foods in a conventional sense.
In addition, when the health food composition of the present invention is used in the form of a drink, it may contain various sweeteners, flavors, or natural carbohydrates as an additional ingredient such as ordinary beverages. In addition to the above, the health food composition of the present invention may contain various nutrients, vitamins, electrolytes, flavors, colorants, pectic acid and salts thereof, alginic acid and its salts, organic acids, protective colloid thickening agents, pH adjusting agents, stabilizers, Alcohols, carbonating agents used in carbonated drinks, and the like. In addition, it may contain flesh for the production of natural fruit drinks, fruit juice drinks and vegetable drinks. The composition of the present invention can be prepared in the form of tea, juice, and drink, and then consumed for drinking, granulated, tableted, encapsulated, and powdered, but the form that can be manufactured by the above example is not limited.
In another aspect, the present invention provides an antioxidant feed composition for eliminating, inhibiting or preventing active oxygen containing hexane diol acid (Hexanedioic acid) as an active ingredient. The feed composition may preferably be achieved by strongly scavenging active oxygen and having an antioxidative or antioxidative effect on active oxygen, as described above.
When the composition of the present invention is used as a feed additive, the composition may be added as it is or may be mixed with other feed ingredients and used appropriately according to a conventional method. The amount of the active ingredient to be mixed may be appropriately determined according to the purpose of use, and the amount of the feed composition of the present invention is not particularly limited.
There is no particular limitation on the kind of the feed of the present invention, and the composition may be supplemented with various auxiliaries such as amino acids, inorganic salts, vitamins, antioxidants, microbial preparations and the like and pulverized or crushed wheat, vegetable protein feeds such as barley, corn, Can be used in combination with nutritional supplements, growth promoters, digestion-absorption promoters, and disease prevention agents in addition to the main components such as animal protein feeds, animal fat and vegetable fat. The dosage form, method and formulation of the feed can be varied, and the form that can be produced by the example is not limited.
The feed composition of the present invention can be applied to a large number of animal diets, i.e. feeds, including mammals, poultry, fish and crustaceans. Commercial livestock can be used for zoo animals such as mammals, elephants, camels, giraffes, monkeys, pets such as cows, pigs, horses, deer and goats; pets such as dogs and cats; , Pigeons, and commercially available fish and crustaceans such as carp, carp, trout, mullet, and shrimp.
Further, in another aspect, the present invention provides an animal pharmaceutical composition for antioxidation for eliminating, inhibiting or preventing active oxygen containing hexanedioic acid as an active ingredient. That is, the composition of the present invention can be used as an animal pharmaceutical composition for the purpose of eliminating, inhibiting or preventing active oxygen. The composition may preferably be achieved by strongly scavenging active oxygen and having an antioxidative or antioxidant effect on active oxygen, as described above. When the composition of the present invention is used as an animal pharmaceutical composition, the composition may be used as it is or may be used together with other pharmaceutical or quasi-drug components, and may be suitably used according to a conventional method, but is not limited thereto. The amount of the active ingredient to be mixed can be suitably determined according to the intended use (prevention, health, improvement or therapeutic treatment).
In addition, in another aspect, the present invention relates to a quasi-drug composition for prevention of eradication, inhibition or prevention of active oxygen containing hexanedioic acid as an active ingredient. That is, the composition of the present invention may be added to a quasi-drug composition for erasing, inhibiting or preventing active oxygen. The composition may preferably be achieved by strongly scavenging active oxygen and having an antioxidative or antioxidative effect on active oxygen, as described above.
When the composition of the present invention is used as a quasi-drug additive, the composition may be added as it is or may be used together with other quasi-drugs or quasi-drugs, and may be suitably used according to a conventional method, but is not limited thereto. The amount of the active ingredient to be mixed can be suitably determined according to the intended use (prevention, health or improvement). The composition of the quasi-drug composition of the present invention is not particularly limited, but is preferably selected from the group consisting of disinfecting cleaner, shower foam, gagrin, wet tissue, detergent soap, spray, hand wash, ointment, And can be used for the production of shampoos, cleansers, female cleaners, cosmetics, shampoos, condoms, sanitary pads, sanitary napkins, bands, filter fillers, sanitary gloves, sanitary bags, sanitary vessels or masks, It is not.
In another aspect, the present invention provides a composition for preserving or preventing oxidation of food containing hexanedioic acid as an active ingredient. That is, the composition of the present invention can be used as a preservative or antioxidant composition for food for erasing or inhibiting active oxygen. The composition may preferably be achieved by strongly scavenging active oxygen and having an antioxidative or antioxidative effect on active oxygen, as described above.
The composition for preserving or preventing oxidation of a pharmaceutical composition, a health food composition, a feed composition, an animal pharmaceutical composition, a quasi-drug composition and a food according to the present invention has strong antioxidative and antioxidative activity against active oxygen, Eradication, inhibition or prevention of diseases and can be used for various antioxidant applications.
FIG. 1 shows the results of measuring the antioxidative activity of each concentration of active oxygen by applying hexanedioic acid to the DPPH assay.
2 shows the results of measuring the antioxidant activity or antioxidative effect of each concentration on active oxygen by applying hexanedioic acid to the DPPH assay.
Hereinafter, the present invention will be described in more detail with reference to examples. However, these examples are for illustrative purposes only, and the scope of the present invention is not limited to these examples.
: material
DPPH powder (1,1-diphenyl-2-picrylhydrazyl), ethanol (EtOH) and methanol (MeOH) were obtained from Duksan Chemical Industry Co., Ltd. and Sigma-Aldrich Co. LLC, St. Louis, .
: Determination of antioxidant activity by DPPH assay (Free radical scavenging assay)
DPPH (1,1-diphenyl-2-picrylhydrazyl, Sigma-Aldrich, USA) was dissolved in ethanol or methanol to confirm the antioxidative activity (active oxygen scavenging ability) of hexanediol acid against active oxygen. (Free radical scavenging activity). In addition, hexane diol acid was dissolved in ethanol or methanol and prepared by concentration. The antioxidant activity of hexane diol acid was measured by DPPH assay.
0.1 ml of 0.1 mM DPPH solution prepared in ethanol and 0.4 ml of ethanol were added and the test substances were added at a concentration of 125 μg / ml, 250 μg / ml, 500 μg / ml and 1,000 μg / ml and vigorously stirred for 10 seconds After storage for 30 minutes in light-blocked cows (room temperature), the absorbance was measured at a wavelength of 517 nm to measure the antioxidant activity of each test substance. The antioxidant activity of the test substances was compared with the control group by adding distilled water as a control. The degree of antioxidant activity was expressed as a percentage based on the absorbance of the control group using distilled water.
As a result, it was confirmed that hexanediol acid highly efficiently scavenges active oxygen through the DPPH assay to show antioxidative activity against active oxygen (FIG. 1 to FIG. 2). These results imply that hexane diol acid is available as an antioxidant composition for scavenging, inhibiting or preventing active oxygen.
In Fig. 1, "+" indicates the antioxidative activity or antioxidative effect of the test substance on active oxygen.
Claims (9)
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| KR1020150092560A KR20170002249A (en) | 2015-06-29 | 2015-06-29 | Antioxidative composition comprising Hexanedioic acid |
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020150092560A KR20170002249A (en) | 2015-06-29 | 2015-06-29 | Antioxidative composition comprising Hexanedioic acid |
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| KR20170002249A true KR20170002249A (en) | 2017-01-06 |
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020175974A3 (en) * | 2019-02-26 | 2020-10-22 | 한국세라믹기술원 | Prussian blue/chitosan nanoparticle complex for removal of active oxygen, and use of same |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2020175974A3 (en) * | 2019-02-26 | 2020-10-22 | 한국세라믹기술원 | Prussian blue/chitosan nanoparticle complex for removal of active oxygen, and use of same |
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