KR20160131487A - Microsponges having controlled solubility and improved redissolution property - Google Patents
Microsponges having controlled solubility and improved redissolution property Download PDFInfo
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- KR20160131487A KR20160131487A KR1020150063965A KR20150063965A KR20160131487A KR 20160131487 A KR20160131487 A KR 20160131487A KR 1020150063965 A KR1020150063965 A KR 1020150063965A KR 20150063965 A KR20150063965 A KR 20150063965A KR 20160131487 A KR20160131487 A KR 20160131487A
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08L—COMPOSITIONS OF MACROMOLECULAR COMPOUNDS
- C08L1/00—Compositions of cellulose, modified cellulose or cellulose derivatives
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/02—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques
- C08J3/03—Making solutions, dispersions, lattices or gels by other methods than by solution, emulsion or suspension polymerisation techniques in aqueous media
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08K—Use of inorganic or non-macromolecular organic substances as compounding ingredients
- C08K5/00—Use of organic ingredients
- C08K5/04—Oxygen-containing compounds
- C08K5/10—Esters; Ether-esters
- C08K5/101—Esters; Ether-esters of monocarboxylic acids
- C08K5/103—Esters; Ether-esters of monocarboxylic acids with polyalcohols
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08L5/00—Compositions of polysaccharides or of their derivatives not provided for in groups C08L1/00 or C08L3/00
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- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
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- C08J2300/14—Water soluble or water swellable polymers, e.g. aqueous gels
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Abstract
Description
The present invention relates to a micro sponge having improved solubility control and re-dissolution characteristics, and more particularly, to a micro sponge having a water-soluble or water-dispersible disintegrant which can be used as a matrix component and capable of controlling solubility and improving re- ≪ / RTI >
Generally, a microsponge-shaped molded article is prepared by cooling a water soluble polymer material solution or an interface side of a gel with an air layer to generate a temperature gradient parallel to the thickness direction in the solution or gel and preliminarily freezing the solution or gel, Freeze-drying the solution or gel of the water-soluble polymer material which has been frozen. The microsponge-shaped molded article thus produced is used in various fields such as cosmetics, foods, especially health supplements, wound dressings, medicines such as disintegration preparations for oral cavity, household products with direction and deodorizing action, industrial products such as pesticides and fertilizers have.
The freeze-dried product of the microsponge type includes collagen or hyaluronic acid, which is a natural polymer, as a matrix component. Collagen sponge having no network bond is prepared from collagen aqueous solution by lyophilization, or dissolved in an organic solvent And collagen sponge having a crosslinked structure is known to be stable in water (Patent Document 1).
The hyaluronic acid microspheres prepared by adding an epoxy cross-linking agent to the hyaluronic acid solution to hydrogel the mixture, expanding the mixture to give porosity, and freeze-drying the expanded hyaluronic acid hydrogel can adjust the pore size, (Patent Document 2).
However, the non-crosslinked micro sponge based on collagen or hyaluronic acid has a disadvantage in that the mechanical strength is low or it is difficult to control the dissolution rate upon contact with water. In addition, even in the case of the cross-linked microsponge, mechanical strength can be expected to be improved, but it is not redissolved in water and its application is limited.
On the other hand, there is known a method of controlling solubility by controlling pores by preliminary freeze-drying and electric pore control method, but there is a problem that the manufacturing process is complicated and the production cost is increased and the economical efficiency is lowered (Patent Document 3).
Accordingly, the present inventors have found that if a water-soluble natural polymer or a synthetic polymer is used as a matrix component and a water-soluble or water-dispersible disintegrant is contained therein to prepare a freeze-dried microsphony-shaped molded article, The present invention has been completed based on the fact that not only the solubility of the microspheres but also the solubility of the microspheres can be controlled and the re-dissolution characteristics can be remarkably improved upon contact with water.
Disclosure of the Invention The present invention has been made in view of the above problems, and an object of the present invention is to provide a sponge which is capable of controlling solubility, easily controlling the density and strength of the sponge, And also to provide a micro sponge having long-term storage stability and distribution stability.
In order to accomplish the above object, the present invention provides a water-soluble polymer material; And a water-soluble or water-dispersible disintegrant.
The water-soluble polymer material may be at least one selected from the group consisting of betaglucan, hyaluronic acid, hydroxypropylmethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, chitosan, gelatin, polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidone, polyacrylamide, Collagen, carrageenan, pullulan, pectin, chondroitin sulfate, dextran and alginic acid.
The content of the water-soluble polymer material is 0.1 to 50% by weight based on the micro sponge.
The water-soluble disintegrant is selected from the group consisting of low molecular weight carboxymethylcellulose, low molecular weight hydroxypropylmethylcellulose, low molecular weight hydroxyethylcellulose, low molecular weight chitin, low molecular weight chitosan, low molecular weight collagen, low molecular weight polyacrylic acid, Molecular weight polyvinyl alcohol and low molecular weight polyethylene oxide.
The water-soluble disintegrant is characterized by at least one selected from the group consisting of glucose, sucrose, maltose and lactose.
Wherein the water soluble disintegrant is selected from the group consisting of alpha cyclodextrin, beta cyclodextrin, gamma cyclodextrin, hydroxypropyl cyclodextrin, hydroxyethyl cyclodextrin, carboxymethyl cyclodextrin, methyl cyclodextrin and glucosyl cyclodextrin Or more.
The water dispersible disintegrant is characterized by at least one selected from the group consisting of microcolloid silica, nano-clay, titanium oxide, talc or mica inorganic particles, or organic particles which are acrylic powder, nylon powder, polyethylene powder or polypropylene powder.
The weight ratio of the water-soluble polymer material to the water-soluble or water-dispersible disintegrant in the micro sponge is 1: 0.5 to 100.
The micro sponge may further include a function imparting substance.
The microsponge may further include at least one additive selected from the group consisting of a surfactant, a colorant, a flavoring agent, a sweetener, an oil, a wax, and an antioxidant.
The micro sponge is characterized by being a massive or sheet-like shape which can be formed into a spherical shape, a heart shape, a tablet shape, or a sheet shape.
The micro sponge produced according to the present invention is capable of controlling the solubility, facilitating the control of density and strength of the sponge, and exhibiting excellent re-dissolution characteristics, as well as excellent long-term storage stability and distribution stability without addition of a preservative , A spherical shape, a heart shape, a tablet shape, or a sheet shape, and can be applied to foods, medicines, quasi-drugs, cosmetics, household products, animal drugs, agricultural chemicals and industrial products.
BRIEF DESCRIPTION OF THE DRAWINGS FIG. 1 is a schematic view showing the production of a microsponge according to the present invention and collapse of a sponge according to redissolving. FIG.
FIG. 2 is a photograph of the state of hydration of the microsponge prepared in Example 1 of the present invention. FIG.
3 is a scanning electron microscope (SEM) photograph of the microsponge prepared in Example 1 of the present invention.
FIG. 4 is a photograph showing a state in which the microsponge prepared in Comparative Example 1 of the present invention is hydrated. FIG.
5 is a scanning electron microscope (SEM) photograph of a microsponge prepared from Comparative Example 1 of the present invention.
6 is a scanning electron microscope (SEM) photograph of a microsponge prepared from Comparative Example 2 of the present invention.
FIG. 7 is a photograph showing a state in which the micro sponge prepared in Example 3 of the present invention is hydrated; FIG.
8 is a scanning electron microscope (SEM) photograph of a microsponge prepared from Example 3 of the present invention.
Hereinafter, a micro sponge having improved solubility control and remelting characteristics according to the present invention will be described in detail.
The present invention relates to a water-soluble polymer material; And a water-soluble or water-dispersible disintegrant.
First, in the present invention, as a matrix component of the micro sponge, there can be used at least one kind selected from the group consisting of betaglucan, hyaluronic acid, hydroxypropylmethylcellulose, carboxymethylcellulose, hydroxyethylcellulose, chitosan, gelatin, polyvinyl alcohol, polyethylene oxide, polyvinylpyrrolidone, At least one selected from the group consisting of amide, xanthan gum, polymer collagen, carrageenan, fluoran, pectin, chondroitin sulfate, dextran and alginic acid is used. , And those having a high molecular weight having a film-like or massive strength are preferable.
The content of the water-soluble polymer material is preferably 0.1 to 50% by weight, more preferably 0.2 to 30% by weight based on the micro sponge. If the content of the water-soluble polymer material is less than 0.1% by weight based on the micro sponge, the content of the matrix component may be too low to lower the mechanical strength of the micro sponge, and the content of the water-soluble polymer material may be 50% , The content of the water-soluble or water-dispersible disintegrant is relatively low, and there is a possibility that the re-solubility of the micro-sponge upon contact with water is lowered.
The present invention also improves the dissolution rate when the viscosity of the water-soluble polymer solution as a matrix component is lowered or the prepared micro sponge is redissolved in water in the process of manufacturing the microsponge. The water-soluble or water-dispersible And a disintegrant.
Examples of the water-soluble disintegrant include low molecular weight carboxymethyl cellulose, low molecular weight hydroxypropyl methylcellulose, low molecular weight hydroxyethyl cellulose, low molecular weight chitin, low molecular weight chitosan, low molecular weight collagen, low molecular weight polyacrylic acid, Molecular weight polyvinyl alcohol and low molecular weight polyethylene oxide. On the other hand, it may be a water-soluble polymer as long as it has a high solubility and dissolution rate in water in a fibrous, pulp-like, powdery or solid state having a certain crystal structure at room temperature or when heated and dried.
The water-soluble disintegrant may be at least one selected from the group consisting of glucose, sucrose, maltose, and lactose, and may be a powdery or crystalline low-molecular saccharide which is dried.
The water-soluble disintegrant may also be selected from the group consisting of alpha cyclodextrin, beta cyclodextrin, gamma cyclodextrin, hydroxypropyl cyclodextrin, hydroxyethyl cyclodextrin, methyl cyclodextrin, carboxymethyl cyclodextrin and glucosyl cyclodextrin One or more of them may be used, and a dextrin compound or a derivative thereof may be used.
On the other hand, as the water dispersible disintegrant, at least one selected from microcolloid silica, nano clay, titanium oxide, talc, or mica inorganic particles, or organic particles which are acrylic powder, nylon powder, polyethylene powder or polypropylene powder , Inorganic particles or organic particles surface-treated with an organic or inorganic component may be used in order to improve the dispersibility and surface properties of the inorganic particles or organic particles.
The weight ratio of the water-soluble polymer material to the water-soluble or water-dispersible disintegrant in the micro-sponge is 1: 0.5 to 100, and the solubility of the micro-sponge The density and the strength can be easily controlled, and the redissolution characteristics upon contact with water can be maximized, and it is more preferable that the ratio is 1: 1 to 30.
At this time, the organic or inorganic compound-treated porous beads such as cyclodextrin and its derivatives and porous silica are pre-soaked and trapped with low-molecular-function-imparting substance before being dispersed or dissolved in water, and dispersed and dissolved in water, When the micro sponge is disintegrated into water and redissolved, the efficacy can be shown by gradually releasing the function-imparting substance which is immersed in seawater. Such a releasing function can be applied to cosmetics, medicines, household products including deodorant and fragrance, And the like.
Therefore, in the present invention, the micro-sponge may further include a functional property-imparting substance. The functional property-imparting substance may be a whitening agent, an anti-fouling agent, an ultraviolet screening agent, a moisturizer, a wetting agent, a stripping agent, Anti-wrinkle agents, weight loss agents, weight gain agents, ingredients that improve elasticity, ingredients that stimulate collagen or elastin synthesis, anti acne agents, anti-inflammatory agents, antioxidants, anti-free radical ingredients, Antimicrobial agents, analgesic anti-inflammatory agents, antiallergic agents, erectile dysfunction agents, antipyretic analgesics, gastrointestinal drugs, anti-obesity agents, dietary supplements, dietary fibers, essential minerals, tocopherol derivatives, essential oils, peptides, vitamins or their derivatives Proteins, and amino acids, including oral, oral, medicinal, cosmetic or dietary supplements These include at least one standing, but are not limited to these.
The property of the functional property-imparting substance is water-soluble, poorly soluble, oil-soluble or water-dispersible, and may be oily or waxy.
Particularly, in order to contain an oil-phase or wax-like functional property-imparting substance, it is preferable to disperse in an aqueous solution of a matrix component and a disintegrant and freeze-dry the mixture without using conventional methods such as microencapsulation or emulsification, A microsponge in which the function imparting substance is stably embedded in the void of the sponge is obtained.
On the other hand, the micro sponge according to the present invention is one of the technical features having long-term storage stability and distribution stability without adding preservatives, but it is also possible to use preservatives such as preservatives or colors, The microspheres may further contain at least one additive selected from the group consisting of a surfactant, a colorant, a flavoring agent, a sweetener, an antioxidant, and a preservative, .
The shape of the microsponge after lyophilization may shrink or expand depending on the design of the container used in the lyophilization process and the characteristics of the raw material, the surface characteristics and color may be changed, and the shape of the microsponge may be spherical, And is obtained in the form of a mass or sheet which can be formulated into a sheet.
Meanwhile, the micro sponge according to the present invention forms pores having a uniform shape in cross section as well as a surface layer, and a water-soluble polymer material as a matrix component and a water-soluble or water-dispersible disintegrant uniformly exist as a sponge like a single substance. Electron microscope (SEM). Furthermore, when hydrated in water, the water rapidly flows into the pores by capillary action, and the rapidly dissolving or dispersing disintegrant first rapidly dissolves or disperses, thereby inducing the internal penetration of water much faster, It was confirmed that the water-soluble polymer material as the matrix component was continuously hydrated and melted again in a sufficient amount of the water reached, and it was disintegrated / dissolved at a very high speed. On the other hand, conventionally, the microsponge-like molded product manufactured only with the water-soluble solid agent has a similar structure. However, in the case of the microsponge made only of the water-soluble solid agent, water is rapidly introduced into the pores by the capillary phenomenon like in the micro- However, since the water-soluble solid material in the outer portion is hydrated and dissolved, the viscosity of the water-soluble solid material rapidly increases to prevent further water from being introduced into or transferred to the inside, and it takes a long time until the water- There is a disadvantage that it is difficult to completely dissolve unless it is rubbed, stirred or shaken and then hydrated and dissolved in water by physical force.
Hereinafter, embodiments and comparative examples according to the present invention will be described in detail with reference to the accompanying drawings. FIG. 1 is a schematic view showing the disintegration of a sponge according to the preparation and redissolution of the microsponge according to the present invention.
[Example 1] Preparation of micro sponge containing water-soluble disintegrant 1
3 g of water-soluble disintegrant, marine collagen (low molecular weight collagen) and 5 g of water-soluble oligochitosan (low molecular weight chitosan) were added to 100 g of aqueous solution of betaglucan as a water-soluble polymer material (0.5 wt%) and dissolved at room temperature to obtain a mixed solution. Subsequently, the mixed solution was put into a spherical mold having a diameter of 11 mm, put in a cryogenic freezer and frozen at -40 ° C for 1 hour. Finally, the frozen ball was separated from the mold and exposed to a freeze dryer to be dried for 24 hours to prepare a microsponge.
[Example 2] Preparation of micro sponge containing water-soluble disintegrant 2
A microsphere was prepared in the same manner as in Example 1 except that 30 g of an aqueous solution of betaglucan (1% by weight) and 70 g of an aqueous solution of sodium hyaluronate (0.5% by weight), 2 g of betacyclodextrin and 2 g of marine collagen were used, .
[Example 3] Preparation of microsponge containing functional-imparting substance
20 g of an aqueous solution of betaglucan (1 wt%) and 80 g of an aqueous solution of sodium hyaluronate (0.5 wt%) were mixed and stirred to obtain a mixed solution. On the other hand, a mixture of 2 g of hydroxypropylcyclodextrin and 2 g of marine collagen was prepared, and shear butter was added to an oil mixture of 1 g of rosehip oil and 1 g of tocopherol to dissolve shea butter at 70 캜. Then, the oil mixture was poured into a mixture of hydroxypropylcyclodextrin and marine collagen powder to form a dough, which was then dispersed again in a mixed solution of an aqueous solution of betaglucan and an aqueous solution of sodium hyaluronate. Microspheres were prepared from the dispersion solution in the same manner as in Example 1.
[Example 4] Preparation of microsponge containing functional imparting substance and additives
30 g of an aqueous solution of betaglucan (0.5% by weight) and 70 g of sodium hyaluronate aqueous solution (0.5% by weight) were mixed and stirred, 1 g of marine collagen and 1 g of nylon powder were dissolved to obtain a mixed solution and left at a low temperature (4 캜). On the other hand, 3 g of rosehip oil and 0.5 g of tocopherol were dissolved in 12 g of alpha-cyclodextrin, dissolved again in the mixed solution and dispersed, and reddish pink red ginseng extract was dissolved together. To prepare a microsponge.
[Comparative Example 1] Preparation of a microsponge not containing a water-soluble disintegrant 1
Microspheres were prepared from the aqueous solution of sodium hyaluronate in which 1 g of sodium hyaluronate had been dissolved in 100 g of water in the same manner as in Example 1.
[Comparative Example 2] Preparation of micro sponge containing no water-soluble disintegrant 2
Microspheres were prepared from the aqueous solution of betaglucan in which 1 g of betaglucan was dissolved in 100 g of water in the same manner as in Example 1.
FIG. 2 is a photograph showing the state of hydration of the micro sponge prepared in Example 1 of the present invention. As shown in FIG. 2, after the micro ball sponge produced is dropped in water, It can be seen that the water rapidly flows into the pores formed by freeze-drying without being subjected to the external force, by the capillary phenomenon, and at the same time, the microsponge is rapidly collapsed while the disintegrant dissolves and melts.
3 shows a scanning electron microscope (SEM) photograph of the microsponge prepared in Example 1 of the present invention. As shown in FIG. 3, the water-soluble polymer material and the water-soluble disintegrant are uniformly separated from each other And it can be confirmed that pores of regular cells are formed.
Meanwhile, FIG. 4 is a photograph showing the state of hydration of the micro sponge prepared in Comparative Example 1 of the present invention. As shown in FIG. 4, the micro ball sponge produced was dropped into water, As a result, the hydration speed becomes slower as time elapses, and finally, it takes a long time to completely dissolve unless external physical external force is applied.
5 and 6 show scanning electron microscope (SEM) photographs of the microsponge prepared from Comparative Examples 1 and 2 of the present invention, respectively. The microsponge prepared in Comparative Example 1 is a relatively uniform cell However, in the case of the micro sponge prepared in Comparative Example 2, the pores were well formed, while the cell walls were too thin and spongy to be hydrated, but the structure was so weak that it could not be handled You can confirm that you have it.
FIG. 7 is a photograph showing the state of hydration of the micro sponge prepared in Example 3 of the present invention. As shown in FIG. 7, the content of the oil component as a function imparting substance not included in the micro sponge prepared in Example 1 The hydration of the hydroxypropylcyclodextrin and the low molecular weight marine collagen used as the water-soluble disintegrant rapidly proceeded, and the collapse was observed at a rate substantially similar to that of Example 1, despite the fact that the oil was dispersed in the pores of the sponge . It is repeatedly found that water-soluble disintegrants play an important role in re-dissolving the sponge in water.
8 shows a scanning electron microscope (SEM) photograph of the microsponge prepared in Example 3 of the present invention, in which oil components that are not soluble in water are uniformly dispersed in the uniformly formed voids .
Table 1 below shows the re-dissolution time of each micro-sponge hydrated solution prepared from Examples 1 to 4 and Comparative Examples 1 and 2, and the feeling of use when applied to the skin.
1) Composition of serum: 10 parts of butylene glycol, 3 parts of glycerin, 0.3 part of phage / PPE-17/6 copolymer, 0.2 part of PPE-75, 1 part of xanthan gum, 0.3 part of oil, 0.1 part of disodium dithiophosphate, 1 part of sodium hyaluronate, 3 parts of chamomile flower / leaf extract, 0.5 part of sage extract, 0.5 part of lavender extract, 3 parts of rosemary leaf extract, 0.8 part of phenoxyethanol, 0.3 parts of fragrance and 76 parts of purified water
2) It can not be treated easily, so it can not be applied smoothly
As shown in Table 1, the microsponges prepared in Examples 1 to 4 of the present invention had remarkably shorter redissolution times than the microsponge prepared in Comparative Example 1, even when the hydration solution was water or an untreated solution (Comparative Example 2 Can not be handled, so it is not applicable to the skin including application of the skin, so it has no meaning in the redissolution time). In addition, it was confirmed that the micro sponge manufactured from the present invention has excellent long-term storage stability and distribution stability even when no conventional preservative is contained.
Therefore, the micro sponge produced according to the present invention is capable of controlling the solubility, easily adjusting the density and the strength of the sponge, and exhibiting excellent re-dissolution characteristics, as well as excellent long-term storage stability and excellent distribution stability without adding preservatives Therefore, it can be applied to foods, medicines, quasi-drugs, cosmetics, daily necessities, animal drugs, pesticides, industrial products, etc. in the form of spherical, heart, tablet or sheet.
Claims (13)
A water-soluble or water-dispersible disintegrant.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018034364A1 (en) * | 2016-08-18 | 2018-02-22 | 주식회사 블리스팩 | Microsponge having enhanced solubility control and redissolution properties |
| CN114945350A (en) * | 2020-01-17 | 2022-08-26 | 布丽思培有限公司 | Solid personal care product and method of making same |
Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001057121A1 (en) | 2000-02-03 | 2001-08-09 | Menicon Co., Ltd. | Spongy molding comprising water-soluble polymeric material and method of controlling pores thereof |
| KR20070064329A (en) | 2007-03-23 | 2007-06-20 | 군제 가부시키가이샤 | Process for producing collagen sponge, process for producing artificial skin, artificial skin and cell tissue culture substrate |
| KR20070108062A (en) | 2006-05-04 | 2007-11-08 | 재단법인서울대학교산학협력재단 | Preparation method of porous hyaluronic acid sponge for cell delivery system |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007197649A (en) * | 2006-01-26 | 2007-08-09 | Omikenshi Co Ltd | Sponge comprised of polysaccharide material |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2001057121A1 (en) | 2000-02-03 | 2001-08-09 | Menicon Co., Ltd. | Spongy molding comprising water-soluble polymeric material and method of controlling pores thereof |
| KR20070108062A (en) | 2006-05-04 | 2007-11-08 | 재단법인서울대학교산학협력재단 | Preparation method of porous hyaluronic acid sponge for cell delivery system |
| KR20070064329A (en) | 2007-03-23 | 2007-06-20 | 군제 가부시키가이샤 | Process for producing collagen sponge, process for producing artificial skin, artificial skin and cell tissue culture substrate |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018034364A1 (en) * | 2016-08-18 | 2018-02-22 | 주식회사 블리스팩 | Microsponge having enhanced solubility control and redissolution properties |
| CN114945350A (en) * | 2020-01-17 | 2022-08-26 | 布丽思培有限公司 | Solid personal care product and method of making same |
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