KR20160108111A - Biological information measuring device and manufacturing method thereof - Google Patents

Abstract

According to various embodiments of the present invention, a biometric information measuring apparatus includes: a sensor unit; and a needle unit prepared to protrude from a plurality of openings formed on one surface of the sensor unit, and having a plurality of needles which penetrate into a body. The needles may include: an enzyme member reacting to an analysis material; and a biocompatible organic material mixed with a conductive polymer which transfers an electric signal generated by the reaction of the enzyme member. In addition, the biometric information measuring apparatus can be variously implemented according to embodiments.

Description

TECHNICAL FIELD [0001] The present invention relates to a biometric information measuring apparatus,

Various embodiments of the present invention relate to a biometric information measuring apparatus and a method of manufacturing the same.

Generally, a needle is used to acquire a sample from a living body, to detect user's biometric information, or inject a drug into a living body. Most of these needles are micro-needles having a millimeter-diameter diameter.

Particularly, in the case of diabetic patients, in order to measure blood glucose (referred to as glucose level in the blood), blood glucose measurement is carried out in a blood glucose measuring device such as a blood glucose strip To measure the glucose level in the blood of the measurer. However, such a blood glucose measuring apparatus needs to collect blood from a finger of a measurer using a lancet whenever blood sugar is measured, and measures blood glucose of the collected blood using a strip sensor and a reader.

Therefore, instead of measuring the blood sugar while the measurer collects blood every time, the user can measure the blood glucose through the body fluid present in the skin layer or the dermal layer by penetrating the micro needle to the user's skin layer or the dermal layer for a certain time.

A plurality of microneedles are arranged on a base substrate, and a plurality of microneedles are infiltrated into a user's skin layer or dermis layer to form a skin layer or a dermis layer. Of the body fluid of the measurer has a structure to measure blood sugar.

Such a microneedle is provided with a base needle protruding from the base substrate and made of a material such as silicon and a catalyst and a sensing layer coated on the outer circumference of the base needle. However, when the micro needle is infiltrated into the user's epidermal layer or the dermal layer, or when the micro needle is removed in the infiltrated state or the infiltrated state, there may be a case where the micro needle is dislodged from the base substrate and stuck to the epidermal layer or the dermal layer of the measurer. In this case, the microneedles must be left or removed from the user's skin, which may amplify anxiety for users using a microneedle blood glucose meter. In addition, the catalyst or the sensing layer coated on the outer periphery of the base needle in the process of carrying the micro needle or in the process step or the like may be realized in a state where the base needle is partly dropped off or not coated. In the case where the catalyst or the sensing layer is provided in a state in which the base needle is detached, in measuring the blood glucose level through the micro needle, the error range of the blood sugar value of the measurer may increase or the blood glucose level may not be measured. In addition, the reliability of the micro needle glucose meter is inevitably lowered as the error range of the blood sugar value is increased or the blood sugar value is not measured when the micro needle glucose meter is measured.

In the process of manufacturing a micro needle glucose meter, since a micro needle type base needle is implemented on a base substrate and a conductive layer, a sensing layer and a coating layer are stacked on the outer periphery of the base needle, The fabrication process is complicated, and as the various layers such as the conductive layer, the sensing layer, and the coating layer are stacked on the outer peripheral surface of the base needle, the defect rate due to this is inevitably increased. In addition, as described above, it is not easy to ensure reproducibility due to an increase in the number of layers on the base needle.

In addition, when arranging the micro needle arranged as the working electrode in the micro needle glucose meter and the micro needle arranged in the reference electrode or the counter electrode rather than the working electrode, arrangement between them can not be efficiently arranged.

Further, in the microneedle blood glucose meter, a packaging process is required in which electrodes other than the working electrode and the working electrode, the sample reference electrode, and the counter electrode are assembled and assembled.

Accordingly, various embodiments of the present invention provide a biometric information measuring apparatus and a method of manufacturing the same that can ensure stability even if the micro needle is dropped in the dermal layer of the measurer.

In addition, various embodiments of the present invention can provide a biometric information measuring device capable of securing an accurate blood glucose level when the blood glucose level is measured through the micro needle, even if the catalyst and the sensing layer are separated from the outer circumference of the micro needle, Method.

The present invention also provides a biometric information measuring device and method for manufacturing the same that minimizes the number of manufacturing steps of a micro needle and secures reproducibility in manufacturing a micro needle.

It is another object of the present invention to provide a biometric information measuring apparatus and a method of manufacturing the same that can be efficiently arranged when the micro needles are arranged as working electrodes and other electrodes.

The apparatus for measuring bio-information according to various embodiments of the present invention includes: a sensor unit; And a needle portion protruding from a plurality of openings formed in one surface of the sensor portion and having a plurality of needles penetrating into the body, wherein the needles include an enzyme member reacting with the analyte, And a biocompatible organic material mixed with a conductive polymer that carries an electrical signal generated by the biocompatible organic material.

A method of manufacturing a bio-information measuring apparatus according to various embodiments of the present invention includes a housing having a substrate portion having a first space portion and a second space portion connected to the first space portion on the substrate portion, Stacking; Stacking a mold part having a concave needle tip shape on the top of the housing; An enzyme member which is provided at a lower portion of the substrate portion and reacts with the analyte through at least one opening of a pair of openings connected to the first space portion, a conductive polymer that transmits an electric signal generated by the reaction of the enzyme member Injecting a mixed biocompatible organic material; Polymerizing the biocompatible organic material mixed with the conductive polymer and the enzyme member injected to the needle tip of the mold unit to form a needle unit; And removing the mold part.

According to various embodiments of the present invention, there is provided a needle member for measuring bio-information, wherein the needle member includes a plurality of needles penetrating into a body and made of a body, the needles having an enzyme member And a biocompatible organic material mixed with a conductive polymer that transmits an electric signal generated by the reaction of the enzyme member.

In the apparatus and method for measuring bio-information according to various embodiments of the present invention, when a needle portion formed of a plurality of micro-needles is left in the skin layer or the dermal layer of the measurer due to, for example, scattering in the sensor portion, the skin layer is melted and disappears in the dermal layer Thus ensuring stability.

In addition, various embodiments of the present invention can be applied to a method of manufacturing a needle unit, a method of manufacturing a needle unit, a method of manufacturing the same, It is possible to obtain a numerical value of accurate biometric information without causing a numerical difference between the needle portion before the breakage and the needle portion after the breakage in the measurement of the biometric information even if the circumference is lost or broken.

In addition, the needle portion according to various embodiments of the present invention can be formed by molding a first member or a second member after the sensor portion, specifically, the electrode portion and the substrate, the housing, and the mold portion are laminated, The number of manufacturing steps of the apparatus can be minimized, and reproducibility can be ensured in manufacturing the micro needle.

In addition, the needle portion according to various embodiments of the present invention is characterized in that the needle portion is formed by injecting the first member or the second member after the sensor portion, specifically, the electrode portion and the substrate, the housing and the mold portion are laminated, Other electrodes can be efficiently arranged, and these electrodes can be easily assembled.

1 is a schematic perspective view of an apparatus for measuring bio-information according to various embodiments of the present invention.
2 is an exploded perspective view of a bio-information measuring apparatus according to various embodiments of the present invention.
3 is a schematic cross-sectional view of a bio-information measuring apparatus according to various embodiments of the present invention.
4 is a view showing a main substrate in a bio-information measuring apparatus according to various embodiments of the present invention.
5A to 5D are views showing various shapes of a reservoir in a bio-information measuring apparatus according to various embodiments of the present invention.
6 is a view showing an electrode unit including two electrodes or three electrodes in a bio-information measuring apparatus according to various embodiments of the present invention.
7 is a perspective view schematically showing a manufacturing process of a bio-information measuring apparatus according to various embodiments of the present invention.
FIG. 8 is a view schematically showing a needle part being formed in a biometric information measuring apparatus according to various embodiments of the present invention. FIG.
9 is a view showing another shape of a needle portion in a bio-information measuring apparatus according to various embodiments of the present invention.
10 is a view showing a state in which a biological information measuring apparatus is infiltrated into a dermal layer of a user in a biological information measuring apparatus according to various embodiments of the present invention.
11 is a view schematically showing that a bio-information measuring device according to various embodiments of the present invention can be attached to a user's body and interlocked with a bio-information measuring device and an external electronic device.
12 is a block diagram schematically showing a manufacturing process of a bio-information measuring apparatus according to various embodiments of the present invention.

The present invention is capable of various modifications and various embodiments, and some embodiments will be described in detail with reference to the drawings. It should be understood, however, that the invention is not intended to be limited to the particular embodiments, but includes all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Also, in connection with the description of the drawings, the same or similar reference numerals may be used for similar components.

Terms including ordinals such as "first", "second", etc. may be used to describe various elements, but the elements are not limited to these terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as a second component, and similarly, the second component may also be referred to as a first component. The term " and / or " includes any combination of a plurality of related listed items or any of a plurality of related listed items.

In addition, relative terms described on the basis of what is shown in the drawings such as 'front', 'rear', 'top', 'under', etc. may be replaced with ordinals such as 'first', 'second' The ordinal numbers such as 'first', 'second', and the like may be arbitrarily changed in accordance with necessity, as the order is arbitrarily determined.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In the present invention, the term "comprises" or "having ", etc. is intended to specify that there is a feature, number, step, operation, element, But do not preclude the presence or addition of one or more other features, integers, steps, operations, elements, components, or combinations thereof.

Unless defined otherwise, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the meaning in the context of the relevant art and are to be interpreted as ideal or overly formal in the sense of the present invention Do not.

In the present invention, the electronic device may be any device having a touch panel, and the electronic device may be referred to as a terminal, a mobile terminal, a mobile terminal, a communication terminal, a portable communication terminal, a portable mobile terminal, a display device and the like.

For example, the electronic device can be a smart phone, a mobile phone, a navigation device, a game machine, a TV, a head unit for a car, a notebook computer, a laptop computer, a tablet computer, a Personal Media Player (PMP) have. The electronic device may be implemented as a pocket-sized portable communication terminal having a wireless communication function. Further, the electronic device may be a flexible device or a flexible display device.

The electronic device can communicate with an external electronic device such as a server, or can perform an operation through interlocking with an external electronic device. For example, the electronic device can transmit the image captured by the camera and / or the position information detected by the sensor unit to the server via the network. The network may include, but is not limited to, a mobile or cellular network, a local area network (LAN), a wireless local area network (WLAN), a wide area network (WAN) (SAN) or the like.

1 is a schematic perspective view of an apparatus 100 for measuring bio-information according to various embodiments of the present invention. 2 is an exploded perspective view of an apparatus 100 for measuring bio-information according to various embodiments of the present invention. 3 is a schematic cross-sectional view of an apparatus 100 for measuring bio-information according to various embodiments of the present invention.

1 to 3, the apparatus 100 for measuring bio-information according to an exemplary embodiment of the present invention may include a sensor unit 110 and a needle unit 140. The bio- The mold unit 150 may be further included to form the needle unit 140 in the process of fabricating the needle unit 100.

The sensor unit 110 may be configured to receive biometric information of a user H (see FIG. 11) detected through the needle unit 140 and to detect various biometric information therefrom. The sensor unit 110 may be formed such that a needle unit 140 described later protrudes from one side of the sensor unit 110 inside the sensor unit 110. The sensor unit 110 may be provided with a space for accommodating the base 140 I of the needle unit 140. The sensor unit 140 may be disposed on the base 140 I of the needle unit 140, 110). ≪ / RTI > A needle unit 140 may be made of a biocompatible organic material 141 mixed with an enzyme member 142 and a conductive polymer 143. The biocompatible organic material 141 may be a biocompatible organic material. The needle portion 140 may be formed on the surface of the sensor portion 110 from the inside of the sensor portion 110 as the biocompatible organic material 141 mixed with the enzyme member 142 and the conductive polymer 143 is polymerized And can be shaped to protrude. Although not shown, the sensor unit 110 is connected to a circuit unit, for example, a communication module through a connector or the like, to transmit or receive biometric information measured by the sensor unit 110 to another electronic device, for example, . In the case of the electronic device, the information received through the circuit unit may be stored or the stored information may be transmitted to the bio-information measuring apparatus 100. Such an electronic device may include a display module to display biometric information, for example, blood sugar information of a detector, and may display various information such as food intake according to the blood glucose concentration of the user (H, see FIG. 11) There is also water. In addition, the electronic device may be provided so that the information detected by the bio-information measuring apparatus 100 may be displayed on a real-time, date-by-date, or numerical basis so that the user can confirm it by the user (see FIG. 11).

The sensor unit 110 may include a substrate unit 120 and a housing 130.

The substrate part 120 may be disposed under the housing 130 and the biocompatible organic material 141 or the enzyme member 142 in which an enzyme member 142 and a conductive polymer 143 described later are mixed may be mixed The first space 125 may be formed so that the biocompatible organic material 141 mixed with the conductive polymer 143 is injected and filled. The substrate portion 120 may include a main substrate 121 and electrode portions 122 and 123 such as a first electrode 122 and a second electrode 123. The main substrate 121 is disposed under the housing 130 and the electrode units 122 and 123 may be disposed on at least one surface of the main substrate 121. For example, the electrode portions 122 and 123 may include a first electrode 122 and a second electrode 123 disposed on the main substrate 121 and on the lower portion thereof, as in the embodiment of the present invention. However, the electrode portions 122 and 123 may be disposed only on the upper portion of the main substrate 121, or may be disposed only on the lower portion of the main substrate 121. When the first electrode 122 and the second electrode 123 are disposed on the upper and the lower portions of the main substrate 121 as in the first embodiment of the present invention, ), The main substrate 121, and the first electrode 122 in this order. The base 140 I of the needle portion 140 is connected to the first electrode 122 and the second electrode 123. The conductive polymer 143 included in the needle portion 140 is electrically connected to the needle portion 140 (Or current) generated by the reaction of the enzyme member 142 while being in contact with the first electrode 122 and the second electrode 123 at the base 140 I 140 I 140 of the electrode unit 122, 123).

4 is a view showing a main substrate 121 in the bio-information measuring apparatus 100 according to various embodiments of the present invention. 5A to 5D are views showing various shapes of the reservoir 126a in the bio-information measuring apparatus 100 according to various embodiments of the present invention.

4 to 5D, a biocompatible organic material 141 including an enzyme member 142 and a conductive polymer 143 or a biocompatible organic material 141 including a conductive polymer 143 is formed on a main substrate 121, A receiving portion 126 may be provided to be molded in a state of being drawn and filled. The first and second electrodes 122 and 123 may be disposed on the upper and lower surfaces of the main substrate 121, respectively. The receiving portion 126 may be connected to the first opening 127 formed in the first electrode 122 and the second opening 128 formed in the second electrode 123. [ The reservoir 126 may be provided with a reservoir 126a. The reservoir 126a is formed by inserting the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 introduced into the storage portion 126 or the biocompatible organic material 141 including the conductive polymer 143 into a molding Which is a constituent for buffering a change in the volume that is generated.

The reservoir 126a according to an embodiment of the present invention includes a first opening 127 in a receiving portion 126 spaced apart from the second opening 128 by a predetermined distance and having the same size as the second opening 128, (See FIG. 4) will be described. However, the shape of the reservoir 126a is not limited thereto.

For example, the reservoir 126a is provided between the first opening 127 and the second opening 128, and the receiving portion 126 itself is formed larger than the second opening 128, and the first opening 127, May be formed to have a size corresponding to the accommodating portion 126 (see FIG. 5A). The reservoir 126a is provided between the first opening 127 and the second opening 128 so that the receiving portion 126 itself is formed to be larger than the first opening 127 and the second opening 128 (5b). The upper and lower surfaces of the reservoir 126 are connected to the first opening 127 and the second opening 128 by the same size and the reservoir 126a is connected to the first opening 127 and the second opening 128, (See FIG. 5C) between the first and second openings 128 and 128, respectively. Alternatively, the reservoir 126a may be disposed between the first opening and the second opening to protrude in one direction from one side of the receiving portion 126 (see FIG. 5D).

FIG. 6 is a view showing electrode units 122 and 123 provided as two or three electrodes in the apparatus 100 for measuring bio-information according to various embodiments of the present invention.

6, the electrode units 122 and 123 (refer to FIGS. 1 to 3) are provided on the main substrate 121 and are electrically connected to the first electrode 122 and a second electrode 123. The second electrode 123 may be formed of a conductive material. In addition, the electrode units 122 and 123 according to an embodiment of the present invention may be provided with two electrodes or three electrodes for detecting a biometric information signal. When the electrode units 122 and 123 are provided as two electrodes, the working electrodes WE, 122W and 123W and the counter electrodes CE and 122W provided around the working electrodes WE, 122C and 123C and a working electrode WE and 122W and a working electrode 123W when the electrode units 122 and 123 are provided as three electrodes. 122C and 123C around the counter electrodes CE, 122C and 123C and the working electrodes WE and 122W and 123W provided around the counter electrodes CE, And reference electrodes RE, 122R, and 123R (reference electrodes). When the electrode units 122 and 123 are formed as two electrodes, the needle unit 140 may be connected to the two electrodes in correspondence with the positions of the two electrodes. In the present invention, And 123W, which are formed on the sensor unit 110 so as to be connected to each other. When the electrode units 122 and 123 are provided as three electrodes, the needle unit 140 may be provided so as to correspond to the respective positions of the three electrodes, but in the present invention, the working electrode WE, 122W , 123W) on the sensor unit 110 so as to be connected to each other

The working electrode W.E is simply an electrode used for causing a desired reaction, which is also referred to as a working electrode, a working electrode, and a test electrode. The working electrode WE may be formed of various kinds of biomedical information such as glucose, lactic acid, body temperature, blood pressure, skin conductivity, heart rate, electrocardiogram, cholesterol, It may be possible to detect and measure at least one of disease-derived biomarker (BIO-Marker), cytokine, hormone, virus or virus-derived substance, bacterial or bacterial-derived substance.

The counter electrode C.E is also referred to as a counter electrode and is an electrode provided so as to oppose the working electrode W.E in order to allow current to flow in the working electrode W.E. The reference electrode RE is an electrode serving as a practical reference, for example, for measuring a potential difference. For example, when the electrode potential generated between a solution and a metal is measured, its absolute value can not be measured. The relative value can be measured according to the combination with the electrode on the basis of the unchanged value, which is also referred to as a comparative electrode or a reference electrode. When the electrode units 122 and 123 are provided as two electrodes, the bioinformation signal can be calculated by measuring a current generated by applying a potential difference between the working electrode W.E and the counter electrode CE. The working electrode WE is provided for measuring an electric signal and the counter electrode CE is disposed around the working electrode WE so that the working electrode WE And the reference electrode RE may be provided to supply a reference potential to the working electrode WE toward the end of the counter electrode CE.

When the electrode units 122 and 123 are disposed on the upper surface and the lower surface of the main substrate 121 as in the embodiment of the present invention, the first electrode 122 may be provided on one surface of the main substrate 121 And may be electrically connected to the needle portion 140. The second electrode 123 may be provided on the other surface of the main substrate 121 and may be connected to an external connector terminal of the bio-information measuring apparatus 100.

As described above, the first space 125 may be provided in the substrate portion 120 including the main substrate 121 and the first and second electrodes 122 and 123 (see FIGS. 3 and 4). The first space 125 may include a receiving portion 126, a first opening 127, and a second opening 128.

The first opening 127, the accommodating portion 126, and the second opening 128 are connected to each other to form a first electrode 122, a main substrate 121, and a second electrode 123, Thereby forming the first space portion 125. The first space 125 is formed by filling the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143, The biocompatible organic material 141 containing the enzyme member 142 filled in the space portion 125 and the conductive polymer 143 or the biocompatible organic material 141 containing the conductive polymer 143 can be used as the first electrode 122 And the second electrode 123 are electrically connected to each other.

The receiving portion 126 is a component that passes through the inside of the main substrate 121 and forms a space as described above. The receiving portion 126 may have the same shape as the first opening 127 and the second opening 128 described later. The accommodating portion 126 is provided with a biocompatible organic material 141 including the enzyme member 142 injected into the accommodating portion 126 and formed of the conductive polymer 143 and the biocompatible organic material 141 including the conductive polymer 143 The reservoir 126a may be provided to have a predetermined space for changing the volume of the reservoir 126a.

The first opening 127 may be formed to penetrate one surface of the first electrode 122 and the other surface of the first electrode 122 and may be provided corresponding to the position of the receiving portion 126. The first opening 127 may be formed to connect the second space 135 and the receiving portion 126. The first opening 127 is a biocompatible portion including the enzyme member 142 and the conductive polymer 143 injected through the second opening portion 128 and the accommodating portion 126 when the bioinformation measuring apparatus 100 is manufactured. And may be provided to inject the biocompatible organic material 141 including the organic material 141 or the conductive polymer 143 into the second space 135. Each of the first openings 127 may be provided to each of the electrode units 122 and 123. For example, when the electrode portions 122 and 123 are formed of two electrodes, the first openings 127 may be formed on the working electrode W.E and two on the counter electrode C.E. This is because the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 described later or the biocompatible organic material 141 including the conductive polymer 143 is injected into the sensor unit 110 to form the needle portion The first needle portion 140C or the second needle portion 140R which will be described later is formed with the enzyme member 142 and the conductive polymer 143, And 127Ca through which the biocompatible organic material 141 containing the biocompatible organic material 141 or the conductive polymer 143 including the organic polymer material 141 and the conductive polymer 143 are injected into the first opening 127, One of the first space portion 125 and the second space portion 125 when the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is filled The discharge of the air that can be discharged from the air filled in the second space portion 135 It can be provided as (127Wb, 127Cb). In the case where the electrode portions 122 and 123 are formed of three electrodes, the first opening 127 is formed by two electrodes on the working electrode WE, two electrodes on the counter electrode CE, and two electrodes on the reference electrode RE Respectively. This is because the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is injected into the sensor unit 110, One of the first openings 127 provided as a pair when the first electrode unit 140 or the first needle unit 140C or the second needle unit 140R to be described later is formed includes the enzyme member 142 and the conductive polymer 143 127Ca, and 127Ra into which the biocompatible organic material 141 including the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 are introduced, The other one of the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is filled in the first space portion 125 and the second space 135 can be exhausted It may be provided as an outlet (127Wb, 127Cb, 127Rb) of the air.

When the biocompatible organic substance 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic substance 141 including the conductive polymer 143 is filled and formed in the first opening 127, The biocompatible organic material 141 including the member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 may be electrically connected to the first electrode 122.

The second opening 128 may be formed on the second electrode 123. The second opening 128 is provided to be connected to the receiving part 126 at a position corresponding to the receiving part 126 and is made of a biocompatible organic material 141 including an enzyme member 142 and a conductive polymer 143 And the biocompatible organic material 141 including the conductive polymer 143 may be injected. The second openings 128 may be respectively provided in the electrode units 122 and 123. For example, when the electrode portions 122 and 123 are formed of two electrodes, the second opening portion 128 may be formed on the working electrode W.E and two on the counter electrode C.E. This is because the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 described later or the biocompatible organic material 141 including the conductive polymer 143 is injected into the sensor unit 110 to form the needle portion 140 or one of the second openings 128 provided in the pair is formed of the enzyme member 142 and the conductive polymer 143 when forming the first needle portion 140C or the second needle portion 140R, And 128Ca through which the biocompatible organic material 141 containing the biocompatible organic material 141 or the conductive polymer 143 containing the biocompatible organic material 141 containing the organic compound 141 and the conductive polymer 143 are injected, One of the first space portion 125 and the second space portion 125 when the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is filled An air discharge port 1 for discharging the air filled in the second space portion 135 28Wb, 128Cb). When the electrode portions 122 and 123 are formed of three electrodes, the second opening portion 128 is formed of two electrodes on the working electrode WE, two electrodes on the counter electrode CE, and two electrodes on the reference electrode RE Respectively. This is because the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is injected into the sensor unit 110, One of the second openings 128 provided as a pair when forming the second needle portion 140 or the first needle portion 140C or the second needle portion 140R to be described later is formed of the enzyme member 142 and the conductive polymer 143 128Ca, and 128Ra into which the biocompatible organic material 141 including the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 may be introduced, The other one of the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is filled in the first space portion 125 and the second space 135 can be exhausted It may be provided with an outlet (128Wb, 128Cb, 128Rb) of the air.

The biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is formed in the second opening 128 in the first space 125, The biocompatible organic material 141 including the biocompatible organic material 141 or the conductive polymer 143 including the formed enzyme member 142 and the conductive polymer 143 is formed by filling the first and second space parts 135 and 135. [ May be electrically connected to the first electrode 122.

When the biometric information is input through the needle unit 140, for example, the enzyme member 142 provided in the needle unit 140 reacts with analyte in the body, and the reacted information is transmitted to the first electrode 122 And the base portion 140 of the needle portion 140 filling the first opening portion 127 and the base portion 140 of the needle portion 140 filling the second opening portion 128 The reaction information of the enzyme member 142 can be transmitted to the electrode units 122 and 123, respectively.

The housing 130 is stacked on the substrate 120 and a second space 135 connected to the first space 125 can be formed inside the housing 130. In addition, The needle portion 140 or a first needle portion 140C or a second needle portion 140R to be described later may protrude from one side of the housing 130 through the first needle portion 135 and the second needle portion 140R.

The housing 130 may include a first body 131 and a second body 132. The first body 131 may be referred to as a partition frame, and the second body 132 may be referred to as a fixed frame.

The first body 131 may be formed on the substrate 120 and specifically on the first electrode 122 to form a second space 135 connected to the first space 125.

The second body 132 is stacked on the upper side of the first body 131 and has a plurality of openings 132a connected to the second space 135, 1 body 131, as shown in FIG. The biocompatible organic material 141 containing the enzyme member 142 and the conductive polymer 143 filled in the second space portion 135 or the biocompatible organic material 141 including the conductive polymer 143 is exposed to the openings 132a of the sensor unit 110. [0051] As shown in FIG. The plurality of openings 132a provided in the second body 132 need not be provided at the same positions or the same number as the needle portions 140. [ That is, the second body 132 may include a biocompatible organic material 141 including an enzyme member 142 and a conductive polymer 143 filled in the second space 135, The biocompatible organic material 141 including the conductive polymer 143 can be introduced into the needle tip 151 and the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 filled in the needle tip 151 The biocompatible organic material 141 including the conductive polymer 141 or the conductive polymer 143 can be prevented from being separated or separated from the second space 135 after being formed through polymerization, 132 and the openings 132a provided in the second body 132 may be deformed or changed at any time.

The second space 135 may be divided into two or three compartments depending on the configuration of the electrode units 122 and 123. That is, the second space portion 135 can be divided into a space corresponding to the position of the working electrode W.E and a space divided into regions corresponding to electrodes other than the working electrode W.E.

For example, as described above, if the electrode units 122 and 123 are provided as two opposing electrodes with respect to the working electrode WE, the second space unit 135 is divided into two compartment spaces, specifically, And can be separated into the compartment space 135W and the second compartment space 135C. The first compartment space 135W is provided corresponding to the position of the working electrode WE and the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 on the working electrode WE side It is a space partitioned to be filled. The second compartment space 135C is adjacent to the first compartment space 135W and the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 on the counter electrode CE, And the biocompatible organic material 141 including the conductive polymer 143 is filled.

If the electrode portions 122 and 123 are provided by three electrodes, that is, the working electrode WE, the counter electrode CE, and the reference electrode RE, the second space portion 135 may include three compartments Specifically, the first partition space 135W, the second partition space 135C, and the third partition space 135R.

The first compartment space 135W is provided corresponding to the position of the working electrode WE and the biocompatible organic material 141 or the biocompatible organic material 141 containing the enzyme member 142 and the conductive polymer 143 on the working electrode WE position And is a space defined so that the biocompatible organic material 141 including the conductive polymer 143 can be filled. The second compartment space 135C is disposed around the periphery of the first compartment space 135W and includes a biocompatible organic material including the enzyme member 142 and the conductive polymer 143 on the counter electrode CE 141 or the biocompatible organic material 141 including the conductive polymer 143 can be filled. The third compartment space 135R is disposed adjacent to the first compartment space and the second compartment space 135C while being disposed at one end side of the second compartment space 135C, A biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or a biocompatible organic material 141 including the conductive polymer 143 is filled.

The first body 131 is connected to the needle 140 through the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or through the biocompatible organic material 141 including the conductive polymer 143. [ The first needle portion 140C or the second needle portion 140R to be described later or the electrode portions 122 and 123 may be divided into functions.

The second body 132 is provided with a plurality of openings 132a at positions corresponding to the electrode parts 122 and 123. The biocompatible organic material 142 including the enzyme member 142 and the conductive polymer 143 The biocompatible organic material 141 including the conductive polymer 141 or the conductive polymer 143 is introduced through the second space 135 and then protruded upward through the opening to be formed on the electrode parts 122 and 123 The base portion 140I + 140II of the needle portion 140 disposed inside the sensor portion 110, for example, the segment of the second space portion 135, while allowing the needle portion 140 to protrude corresponding to the position The base 140 and the housing 130 may be fixed or supported so that the base 140 I + 140 II of the needle unit 140 provided in the space is not detached from the base plate 120 and the housing 130.

The needle part 140 according to various embodiments of the present invention is filled from the first space part 125 and the second space part 135 inside the sensor part 110 (Hereinafter referred to as "micro needle portion 140 III") protruding from one side of the sensor unit 110, for example, the housing 130.

The needle portion 140, for example, the micro needle portion 140 III is protruded from the sensor portion 110 to penetrate the dermis layer H2 of the user H (see FIG. 11), and the first and second space portions 125 and 135 The needle portion base 140I + 140II and the micro needle portion 140II formed to be filled with the needle portion 140 and the micro needle portion 140III may be implemented as one body as a whole. The biocompatible organic material 141a which can be dissolved in the skin even if it penetrates into the skin of the dermal layer H2 (see FIG. 11), specifically the dermal layer H2 and is separated or separated from the sensor portion 110 and remains in the dermal layer H2, And the like.

The needle portion 140 may be embodied as a biocompatible organic material 141 that includes an enzyme member 142 and a conductive polymer 143 and may include an enzyme member 142 and a conductive polymer 143, The biocompatible organic material 141 can be formed by polymerizing and molding

The biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 is a liquid phase and is disposed on the rear surface of the sensor unit 110 after the mold unit 150 is laminated on the sensor unit 110 The needle portion 140 or the first needle portion 140C or the second needle portion 140R protruding from the inner side of the sensor portion 110 can be formed. The process of manufacturing the needle portion 140 or the first needle portion 140C or the second needle portion 140R may be described later in detail.

As described above, the needle unit 140 according to an embodiment of the present invention is described as being disposed at a portion of the working electrode area WEA connected to the working electrode WE, And a biocompatible organic material 141 including a conductive polymer 143. Specifically, the working electrode WE is configured to detect information generated by the reaction of the enzyme member 142 with the bodily fluid, and includes a needle portion 140 disposed on the working electrode WE and connected to the working electrode WE, The enzyme member 142 should be included. The needle portion 140 corresponding to the position of the working electrode WE is made of the biocompatible organic material 141 including the conductive polymer 143 in which the enzyme member 142 is included in the biocompatibility 141a and the conductive polymer 143 141). However, the first needle portion 140C or the second needle portion 1410R provided at a position other than the working electrode WE, for example, the position of the counter electrode CE or the reference electrode RE described below, The biocompatible organic material 141 mixed with the conductive polymer 143 and the conductive polymer 143 may be composed of the biocompatible organic material 141 mixed with the conductive polymer 143 and the biocompatible organic material 141 mixed with the conductive polymer 143, There will be.

In the present invention, the needle portion 140 provided at the position of the working electrode WE may be formed by, for example, describing that the biocompatible organic material 141 in which the enzyme member 142 and the conductive polymer 143 are mixed is formed as a body But is not limited thereto. For example, the needle portion 140, which will be described later and which is located at the working electrode WE, is formed into a single body only with the biocompatible organic material 141 in which the enzyme member 142 is not mixed and the conductive polymer 143 is mixed, The biocompatible organic material 141 mixed with the enzyme member 142 or the enzyme member 142 or the conductive polymer 143 is coated on the outer surface of the molded body molded only with the biocompatible organic material 141 mixed with the polymer 143 The needle unit 140 disposed on the working electrode WE may be modified or changed as long as it has the enzyme member 142 capable of reacting with the reaction material in the body.

The first needle portion 140C or the second needle portion 140R disposed on the counter electrode CE or the reference electrode RE and the enzyme member 142 need not react with the reaction material in the body separately And is provided for the potential difference of the working electrode WE while being stable material such as melting in the body when the micro needle 140I is scattered and left in the body, The first needle portion 140C and the second needle portion 140R to be disposed may be made only of the biocompatibility 141a in which the conductive polymer 143 is mixed. The first needle portion 140C and the second needle portion 140R disposed in the counter electrode CE or the reference electrode RE in the present invention are formed of the biocompatible organic material 142 including the enzyme member 142 and the conductive polymer 143 (141), but the present invention is not limited thereto. All of the electrodes other than the working electrode WE and the working electrode WE can be molded into a biocompatible organic material 141 mixed with the enzyme member 142 and the conductive polymer 143 to be provided in one body, Or change.

The needle portion 140 may be disposed at an electrode other than the working electrode WE and the working electrode WE depending on the function of the electrode portions 122 and 123. Alternatively, A first needle portion 140C and a second needle portion 140R separate from the needle portion 140 are disposed at positions of electrodes other than the working electrode WE, (140). ≪ / RTI >

For example, when the electrode portions 122 and 123 are provided as two electrodes, the needle portion 140 may be disposed on the working electrode WE and the counter electrode CE, and the working electrode WE The needle portion 140 may be disposed on the position of the counter electrode CE and the first needle portion 140C may be disposed on the position of the counter electrode CE.

When the electrode parts 122 and 123 are formed as two electrodes, the upper surface of the housing 130 is divided into a working electrode area WEA connected to the working electrode WE and a working electrode area WEA adjacent to the working electrode area WEA, And may be partitioned into a counter electrode area CEA at a position corresponding to the position of the electrode CE.

A needle portion (hereinafter referred to as an " operation needle portion 140W ") may be provided to protrude from the working electrode region W.E. Further, the operating needle portion 140W may be connected to the first compartment space 135W on the working electrode area W.E. The operating needle portion 140W may be formed by molding the biocompatible organic material 141 mixed with the enzyme member 142 and the conductive polymer 143 and may protrude from one side of the sensor portion 110 from the inside of the sensor portion 110, The entire needle portion 140W, that is, the needle portion base 140 I, 140 II and the micro needle portion 140 III may be provided as one body. The operating needle portion 140W is a one-body molding comprised of the biocompatible organic material 141 including the conductive polymer 143. Alternatively, the operating needle portion 140W may include a biocompatible 141a and conductive The biocompatible organic material 141 including the enzyme member 142 including the polymer 143 f and the conductive polymer 143 is molded to form an operation needle portion 143 protruded from the inside of the sensor portion 110 to one side of the sensor portion 110 140W is provided as one body and the outer surface of the operating needle portion 140W (corresponding to the micro needle portion 140III) protruding to one side of the sensor portion 110 is covered with a biocompatible organic material (141) may be coated thereon.

The first needle portion 140C may protrude from the counter electrode region CEA. Also, the first needle portion 140C may be connected to the second compartment space 135C on the counter electrode area CEA. The first needle portion 140C is formed by molding the biocompatible organic material 141 mixed with the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 mixed with the conductive polymer 143, And the first needle portion 140C may be integrally formed as one body as the needle portion 140 described above.

When the electrode portions 122 and 123 are formed of three electrodes, the needle portion 140 may be disposed on the working electrode WE, the counter electrode CE, and the reference electrode RE The needle portion 140 may be disposed on the position of the working electrode WE and the first needle portion 140C may be disposed on the position of the counter electrode CE, And the second needle portion 140R may be disposed on the position.

When the electrode parts 122 and 123 are formed as three electrodes, the upper surface of the housing 130 is divided into a working electrode area WEA connected to the working electrode WE, And may be disposed adjacent to one end of the counter electrode area CEA and adjacent to the counter electrode area CEA and the working electrode area WEA at a position corresponding to the position of the electrode CE, And a reference electrode region REA corresponding to the position of the reference electrode region REA.

The operating needle portion 140W may be provided to protrude from the working electrode region W.E. Further, the operating needle portion 140W may be connected to the first compartment space 135W on the working electrode area W.E. The operating needle portion 140W may be formed by molding the biocompatible organic material 141 mixed with the enzyme member 142 and the conductive polymer 143 and may protrude from one side of the sensor portion 110 from the inside of the sensor portion 110, The entire needle portion 140W may be provided as one body. Although the operating needle portion 140W is an example of a one-body molding comprised of the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143, the operating needle portion 140W, on the other hand, The biocompatible organic material 141 mixed with the polymer 143 is molded and protruded from the inside of the sensor unit 110 to one side of the sensor unit 110 and the enzyme member 142 or the enzyme member 142 is formed on the outer side of the biocompatible organic material 141, And a biocompatible organic material 141 mixed with a conductive polymer 143 may be coated.

The first needle portion 140C may protrude from the counter electrode region C.E.A. Also, the first needle portion 140C may be connected to the second compartment space 135C on the counter electrode region C.E.A. The first needle portion 140C may be formed of a biocompatible organic material 141 mixed with the enzyme member 142 and the conductive polymer 143 and may protrude from one side of the sensor portion 110 from the inside of the sensor portion 110, The entire first needle portion 140C may be provided as one body. The first needle portion 140C is formed by only the biocompatible organic material 141 mixed with the enzyme member 142 and the conductive polymer 143. However, the enzyme member 142 is not mixed with the conductive polymer 143 143 may be mixed with the biocompatible organic material 141.

The second needle portion 140R may protrude from the reference electrode region REA. In addition, the second needle portion 140R may be connected to the third compartment space 135R on the reference electrode REA. The biocompatible organic material 141 in which the enzyme member 142 and the conductive polymer 143 are mixed may be molded and protruded from the inside of the sensor unit 110 to one side of the sensor unit 110 in the second needle unit 140R, And the entire second needle portion 140R may be provided as one body. The second needle portion 140R is formed of the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143. In the same way as the first needle portion 140C, A biocompatible organic material 141 mixed with a conductive polymer 143 not mixed with the conductive polymer 143 may be used.

7 is a perspective view schematically showing a manufacturing process of the bio-information measuring apparatus 100 according to various embodiments of the present invention. FIG. 8 is a view schematically showing the formation of the needle portion 140 in the apparatus 100 for measuring bio-information according to various embodiments of the present invention.

7 and 8, the needle portion 140 is disposed inside the sensor portion 110, specifically, between the first space portion 125 and the second space portion 135 and the sensor portion 110 ) Are the components of the one body. The needle portion 140 may protrude from a plurality of openings 132a formed on one surface of the sensor portion 110. [

The needle portion 140 (hereinafter, the needle portion 140 is collectively referred to as an operating needle portion 140W, a first needle portion 140C and a second needle portion 140R) The mold part 150 is laminated on the upper part of the sensor part 110 in which the substrate part 120 and the housing 130 are laminated and the enzyme part 142 is formed through the opening part of the rear surface of the sensor part 110 The biocompatible organic material 141 including the conductive polymer 143 and the biocompatible organic material 141 containing the conductive polymer 143 is injected and polymerized to inject the needle 140 ) Can be formed.

The mold unit 150 may be stacked on the housing 130 in a state where the substrate unit 120 and the housing 130 are stacked to form the needle unit 140 on the sensor unit 110. The surface of the mold part 150 facing the mold part 150 and the housing 130 corresponds to the positions of the electrode parts 122 and 123 and the shape of the needle part 140 can be formed A plurality of concave needle tips 151 may be provided. The needle tip 151 formed on the mold part 150 will be divided into the arrangement areas of the electrode tips 122 and 123, for example, the two-electrode or three-electrode arrangement. The mold part 150 may include a biocompatible organic material 141 or a conductive polymer 143 including an enzyme member 142 and a conductive polymer 143 injected through the first space part 125 and the second space part 135 The needle 140 is formed by protruding the biocompatible organic material 141 including the biocompatible organic material 141 on one side of the sensor unit 110 and then removed from the sensor unit 110. The size of the needle tip 151 may be such that the needle 140 has a base length of 30-300 μm on the surface of the sensor 110 and the height of the needle 140 is 200-1,000 um. < / RTI >

When the mold part 150 is stacked on the sensor part 110, the second electrode 123, the main substrate 121, the first electrode 122, the first body 131, the second body 132, And the mold part 150 are stacked in this order. When the sensor unit 110 and the mold unit 150 are stacked as described above, the second electrode 123 is provided with the receiving portion 126, the first opening 127, 2 space portion 135 and the needle tip 151. The needle tip 151 may be connected to the space portion 135 and the needle tip 151,

When the biocompatible organic substance 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic substance 141 including the conductive polymer 143 is injected through the second opening 128, The biocompatible organic material 141 including the member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is formed on the receiving portion 126, the first opening 127, The first space portion 125 and the second space portion 135 inside the sensor portion 110 are filled. The biocompatible organic material 141 or the conductive polymer 143 including the enzyme member 142 and the conductive polymer 143 filling both the first space part 125 and the second space part 135, The conformal organic material 141 may be injected into the needle tip 151 through the opening in the housing 130.

The biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is separated from the first space portion 125 and the second space portion 135 And then the biotissible organic substance 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic substance 141 including the conductive polymer 143 is polymerized to form the sensor unit 110 And the needle part 140 protruding from one side of the sensor part 110 can be formed.

The biocompatible organic material 141 including the fluidized enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 may be subjected to various processes such as electropolymerization, Or base polymerization. In particular, when the enzyme member 142 is mixed with the biocompatible organic material 141, a molded body may be formed by the above-mentioned polymerization method so as to prevent the enzyme member 142 from being damaged during the polymerization process.

When the polymerization is completed, the needle portion 140 is protruded to one side of the sensor portion 110 in a state of being filled in the sensor portion 110, the first space portion 125 and the second space portion 135 .

The conductive polymer 143 may be at least one selected from the group consisting of polypyrrole, polyaniline, polyacetylene, polyphenylene, polyphenylene vinylene, (Poly) phenylene vinylene, polythiophene, poly (diacetylene), and poly 3,4-ethylenedioxythiophene (PEDOT). .

The conductive polymer 143 included in the needle portion 140 can be utilized as a sensor electrode on the surface of the micro needle portion 140III and the conductive polymer 143 can be used as the sensor electrode on the surface of the micro needle portion 140III. And can be electrically connected between the electrode parts 122 and 123 on the surface. In addition, the enzyme member 142 may use a substance that is measured and selected from biometric information and a substance having selectivity.

The biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 may further include a filler.

The biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 is applied to the first space portion 125 and the second space portion 135 ) And knittle tip, the volume change may occur. The filler is used to control the volume change that occurs in the polymerization process of the biocompatible organic material 141 including the enzyme material 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 May be added to the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143. [

The reservoir 126a formed in the accommodating portion 126 may include a biocompatible organic material 142 including an enzyme member 142 and a conductive polymer 143 filled in the first space 125, The volume change may be controlled in the course of polymerizing the biocompatible organic material 141 including the conductive polymer 141 or the conductive polymer 143. [

9 is a view showing another shape of the needle portion 140 in the bioinformation measuring apparatus 100 according to various embodiments of the present invention.

9, the needle portion 140 may be formed of a biocompatible organic material 141, in which the enzyme member 142 is excluded and includes the conductive polymer 143. In this case, the first needle portion 140C, The second needle portion 140R may be made of only the above material, but the operating needle portion 140W should be mixed with the enzyme member 142 capable of reacting with the reaction material in the body. In the case of the operation needle unit 140W, the enzyme member (not shown) is attached to the outer surface of the micro needle portion 140III formed of the biocompatible organic material 141 including the conductive polymer 143 protruding to one side of the sensor unit 110 142 or a biocompatible organic material 141 in which an enzyme member 142 and a conductive polymer 143 are mixed. The portion provided with the micro needle portion 140III coated with the enzyme member 142 may be a pair disposed on the working electrode region W.E.

Accordingly, the biocompatible organic material 141 mixed with the conductive polymer 143 is injected into the sensor unit 110 during the process of the needle unit 140 to form needles, and only the needles on the working electrode area WEA The biocompatible organic material 141 including the enzyme member 142 or the enzyme member 142 and the conductive polymer 143 may be implemented.

10 is a view showing a state in which the biological information measuring apparatus 100 is infiltrated into the dermal layer H2 of the user H (see FIG. 11) in the biological information measuring apparatus 100 according to various embodiments of the present invention. 11 is a schematic diagram of a bio-information measuring apparatus 100 according to various embodiments of the present invention. The bio-information measuring apparatus 100 is attached to the body of a user H (see FIG. 11) Fig. 2 is a view schematically showing that it can be interlocked with an electronic device.

10 and 11, the needle portion 140 may be positioned on the surface of the skin layer H1 existing in the outermost layer of the skin of the user H. When the needle portion 140 is placed on the skin surface and the biometric information measuring device 100 is pressed with a predetermined force, the needles can penetrate the skin layer H1 and the dermal layer H2. At this time, since nerve is not distributed in the epidermal layer (H1) or the dermal layer (H2), if the micro-needle electrode penetrates only the dermal layer (H2), the subject will not be able to sense the pain caused by penetration of the needles. Since the skin layer H1 existing in the outermost layers of the skin has the greatest impedance, it is possible to measure more accurately even if the needles penetrate only the skin layer H1. However, as described above, And the dermal layer H2, a more accurate measurement value can be obtained. Here, when the needle is penetrated to the subcutaneous tissue (H3) under the dermal layer H2 to obtain a more accurate measurement value of the biometric information, since the thickness of the needle is very fine, the initial stimulation of the nerve by the needles, , Pain can be very small.

As described above, the bio-information signal measured in the subcutaneous tissue H3 of the living body by applying the bio-information measuring device 100 to the skin can be transmitted to external electronic devices such as a portable terminal through the needles and electrodes . . The separate electronic device can store the biometric information transmitted from the biometric information measuring apparatus 100. When the display module is provided in the separate electronic device, biometric information, for example, the concentration of blood sugar of the user H can be displayed, and the transmitted biometric information can be displayed as a graph or a statistic, It is possible to confirm the change of the biometric information by various methods such as time or date of own biometric information.

Hereinafter, a method of manufacturing the bio-information measuring apparatus 100 can be examined. In describing the manufacturing method of the bio-information measuring apparatus 100, the above-described components, functions, operations, and the like may be applied mutatis mutandis as described above.

12 is a block diagram schematically showing a manufacturing process of the bio-information measuring apparatus 100 according to various embodiments of the present invention.

12, the biometric information measuring apparatus 100 according to an embodiment of the present invention includes a liquid enzyme member 142 and a conductive polymer 143 in a stacked sensor unit 110, The biocompatible organic material 141 mixed with the conductive polymer 143 or the conductive polymer 143 may be injected and then polymerized and molded to form the needle unit 140.

For example, the substrate 120 having the first space part 125 and the second space part 135 connected to the first space part 125 on the substrate part 120 The housing 130 can be stacked (S10). Specifically, the first body 131 and the second body 132 may be stacked in order in a state where the first electrode 122 is disposed on the main substrate 121. Further, the mold part 150 having the shape of the needle tip 151 concave on the upper part of the second body 132 can be stacked. The second electrode 123 may be mounted on the main substrate 121 when the first electrode 122 is mounted on the main substrate 121. Alternatively, the second electrode 123 may be mounted on the second body 132 The second electrode 123 may be stacked on the rear surface of the main substrate 121 to correspond to the position of the receiving portion 126. In this case,

In this way, the second electrode 123, the main substrate 121, the first electrode 122, the first body 131, the second body 132, and the mold unit 150 are stacked in this order from the bottom Hereinafter referred to as a "first lamination set"), the second opening 128 can be exposed to one surface of the first lamination set. When the electrode parts 122 and 123 are provided as two electrodes, the discharge ports 123Wb and 123Cb and the injection ports 123Wa and 123Ca are formed on the working electrode WE position of the second electrode 123 and the counter electrode CE, Two openings 128 may be exposed to expose four openings. When the electrode units 122 and 123 are provided as three electrodes, the discharge ports 123Wb, 123Cb, and 123Rb and the discharge ports 123Wb, 123Cb, and 123Rb are connected to the working electrode WE, the counter electrode CE, and the reference electrode RE of the second electrode 123, The second openings 128 of the injection ports 123Wa, 123Ca and 123Rb may be exposed to expose the six second openings 128, respectively.

The biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 143 including the conductive polymer 143 is disposed at a position corresponding to the injection port of the second openings 128 thus exposed 141 may be injected (S20).

A biocompatible organic material 141 including an enzyme member 142 and a conductive polymer 143 is injected into the second opening 128 of the working electrode WE and an electrode other than the working electrode WE, The enzyme member 142 may be mixed with the second opening 128 of the counter electrode CE or the reference electrode RE and the conductive polymer 143 may not be mixed with the enzyme member 142 At least one of the mixed biocompatible organic substances 141 may be injected.

Further, the biocompatible organic material 141 including the conductive polymer 143 can be injected onto the working electrode area W.E.A., the counter electrode area C.E.A, and the reference electrode area R.E.A. In this case, the biocompatible organic material 141 (including the enzyme member 142 or the enzyme member 142 and the conductive polymer 143) on the outer surface of the needle formed at the position of the working electrode area WEA after the polymerization step ) May be coated.

The biocompatible organic material 141 including the biocompatible organic material 141 or the conductive polymer 143 including the enzyme member 142 and the conductive polymer 143 injected through the second opening 128 is accommodated in the accommodating portion 126 And then flows into the second space 135 through the first opening 127 to fill the inside of the second space 135 forming the space in the shape of the electrode parts 122 and 123. The biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 filling the entire second space portion 135 or the biocompatible organic material 141 including the conductive polymer 143 may be the second And may be filled into the needle tip 151 of the mold part 150 through the plurality of openings of the body 132.

The biocompatible organic material 141 or the conductive polymer 143 including the enzyme member 142 and the conductive polymer 143 that are filled up to the needle tip 151 of the mold unit 150 and filled with the biocompatible organic material 141 (141) may be formed by using at least one of electric polymerization, thermal polymerization, photopolymerization, acid polymerization or base polymerization (S30). At this time, when the biocompatible organic material 141 including the conductive polymer 143 containing the enzyme member 142 is polymerized, the enzyme member 142 is subjected to electrochemical polymerization during the polymerization in order to prevent destruction in the polymerization process Will be available.

The biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 are polymerized so as to form the inside of the sensor unit 110, The first space portion 125 and the second space portion 135 and the needles projected to one side of the sensor portion 110 may be integrally formed (S40). The mold part 150 may be removed after polymerizing the biocompatible organic material 141 including the enzyme member 142 and the conductive polymer 143 or the biocompatible organic material 141 including the conductive polymer 143 S50).

If the needles 150 are formed only of the biocompatible organic material 141 including the conductive polymer 143 at the positions of the electrodes other than the working electrode WE and the working electrode WE as described above, The biocompatible organic material 141 including the conductive polymer 143 including the enzyme member 142 is coated on the surfaces of the needles protruding to the working electrode WE to react with the reactant in the body .

As described above, the needle portion 140 is a biocompatible organic material including the biocompatible organic material 141 or the conductive polymer 143 including the enzyme member 142 and the conductive polymer 143 in a state where the sensor portion 110 is laminated. Can be formed by injecting and polymerizing the organic material 141, and the manufacturing process is simple and easy. Since the needle portion 140 is integrally formed with the needle protruding from the space inside the sensor portion 110 to one side of the sensor portion 110, the inside or the outside of the needle can be provided with the same composition, The same biometric information can always be realized even if the outside is dropped or a blemish occurs. In addition, since the integrally formed needles are made of the biocompatible material 141a, if the needles are detached from the dermal layer H2 in an invasive state and remain in the dermal layer H2, the needles melt in the dermal layer H2 The risk of use can be reduced by discarding.

The apparatus for measuring bio-information according to various embodiments of the present invention includes: a sensor unit; And a needle portion protruding from a plurality of openings formed in one surface of the sensor portion and having a plurality of needles penetrating into the body, wherein the needles include an enzyme member reacting with the analyte, And a biocompatible organic material mixed with a conducting polymer that carries the electrical signal generated by the biocompatible organic material.

In the apparatus for measuring biometric information according to various embodiments of the present invention, the needles may be formed using at least one of electrochemical polymerization, thermal polymerization, photopolymerization, acid polymerization or base polymerization.

In the biometric information measuring apparatus according to various embodiments of the present invention, the biocompatible organic material may be further mixed with a filler.

In the bio-information measuring apparatus according to various embodiments of the present invention, the sensor unit may include: a substrate unit having a first space portion; And a housing which is stacked on the substrate and forms a second space part connected to the first space part.

In the apparatus for measuring bio-information according to various embodiments of the present invention, the substrate unit may include: a main substrate; And an electrode unit mounted on at least one surface of the main substrate.

In an apparatus for measuring bio-information according to various embodiments of the present invention, the electrode unit may include a first electrode mounted on at least one surface of one surface or the other surface of the main substrate, and electrically connected to the needle unit; And a second electrode provided on one of the surfaces of the main substrate or the other surface and connected to an external connector terminal of the bio-information measuring apparatus.

In the apparatus for measuring bio-information according to various embodiments of the present invention, the first space portion may include: a receiving portion formed on the main substrate; A first opening formed on the first electrode, the first opening connecting the second space and the receptacle; And a second opening formed on the second electrode, connected to the receiving portion, for injecting the first member or the second member.

In the apparatus for measuring bio-information according to various embodiments of the present invention, the first opening and the second opening are provided with an injection port into which the biocompatible organic substance including the enzyme member and the conductive polymer is injected into the accommodation portion, And a pair of outlets for discharging the air of the accommodating portion according to injection of the biocompatible organic material including the conductive polymer may be provided in each pair.

In the apparatus for measuring bio-information according to various embodiments of the present invention, a reservoir may be provided in the receiving part.

In the apparatus for measuring bio-information according to various embodiments of the present invention, the electrode unit may include the working electrode and two electrodes of a counter electrode other than the working electrode, which are located around the working electrode, And three electrodes of a counter electrode and a reference electrode other than the working electrode, which are located around the working electrode.

In the biometric information measuring apparatus according to various embodiments of the present invention, when the electrode portion is provided as two electrodes, the needle portion protrudes from a working electrode region connected to the working electrode, A first needle portion connected to the counter electrode may be provided with a protrusion.

In the biometric information measuring apparatus according to various embodiments of the present invention, the first needle portion may be formed by molding the biocompatible organic material in which the enzyme member and the conductive polymer are mixed into one body, or mixing the conductive polymer with the enzyme member The biocompatible organic material may be molded into a single body.

In the apparatus for measuring bio-information according to various embodiments of the present invention, when the electrode part is provided as three electrodes, the needle part protrudes from a working electrode area connected to the working electrode, The first needle portion may protrude from the counter electrode region corresponding to the electrode position, and the second needle portion may protrude from the reference electrode region adjacent to the working electrode region. The second needle portion may protrude from the reference electrode region. have.

In the apparatus for measuring bio-information according to various embodiments of the present invention, the first needle portion and the second needle portion may be formed by molding the biocompatible organic material in which the enzyme member and the conductive polymer are mixed into one body, The biocompatible organic material may be formed into a single body.

In the apparatus for measuring bio-information according to various embodiments of the present invention, the second spatial part may form a space corresponding to a position of the working electrode and a space corresponding to a position of an electrode other than the working electrode.

In the apparatus for measuring bio-information according to various embodiments of the present invention, when the electrode part is provided as two electrodes, the second space part is provided on the first electrode, and the enzyme member and the conductive polymer A first compartment space in which the biocompatible organic material mixed is filled; And a second biocompatible organic material that is adjacent to the first compartment space and on which the biocompatible organic material in which the enzyme member and the conductive polymer are mixed or the biocompatible organic material in which the conductive polymer is mixed is filled on the counter electrode, It can be partitioned into a compartment space.

In the apparatus for measuring bio-information according to various embodiments of the present invention, when the electrode part is provided as three electrodes, the second space part is provided on the first electrode, and the enzyme member and the conductive polymer A first compartment space in which the biocompatible organic material mixed is filled; Wherein the biocompatible organic material mixed with the conductive polymer and the biocompatible organic material mixed with the conductive polymer is filled on the counter electrode, Compartment space; And one of the biocompatible organic material mixed with the conductive polymer and the biocompatible organic material mixed with the conductive polymer is adjacent to the first compartment space and the second compartment space, And the third compartment space.

In the apparatus for measuring bio-information according to various embodiments of the present invention, the housing may include: a first body formed on the substrate and forming the second space; And a second body formed on the first body, the second body having the opening to be connected to the second space and fixing the plurality of needles in the first body.

A method of manufacturing a bio-information measuring apparatus according to various embodiments of the present invention includes a housing having a substrate portion having a first space portion and a second space portion connected to the first space portion on the substrate portion, Stacking; Stacking a mold part having a concave needle tip shape on the top of the housing; An enzyme member which is provided at a lower portion of the substrate portion and reacts with the analyte through at least one opening of a pair of openings connected to the first space portion, a conductive polymer that transmits an electric signal generated by the reaction of the enzyme member Injecting a mixed biocompatible organic material in the absence of an enzyme; Polymerizing the biocompatible organic material mixed with the conductive polymer and the enzyme member injected to the needle tip of the mold unit to form a needle unit; And removing the mold part.

In the method of manufacturing a bio-information measuring apparatus according to various embodiments of the present invention, the substrate portion may include a main substrate; And an electrode part mounted on at least one surface of the main substrate or one surface of the main substrate and being provided as one of two electrodes or three electrodes.

In the method of manufacturing a bio-information measuring apparatus according to various embodiments of the present invention, when the electrode portion is provided as the second electrode, the electrode portion includes a working electrode and a counter electrode disposed around the working electrode, The electrode unit may include a working electrode, a counter electrode disposed around the working electrode, and a reference electrode disposed around the working electrode and the end of the counter electrode.

In the method of manufacturing a bio-information measuring apparatus according to various embodiments of the present invention, the second space may include a region corresponding to the position of the working electrode according to the second electrode or the third electrode, Each of the compartment spaces can be formed in an area corresponding to the position.

In the method of manufacturing a bio-information measuring apparatus according to various embodiments of the present invention, when the electrode portion is provided as the second electrode, the needle portion is formed in a working electrode region corresponding to the position of the working electrode, The biocompatible organic material in which the enzyme member and the conductive polymer are mixed or the biocompatible organic material in which the conductive polymer is mixed is injected into the counter electrode region corresponding to the position of the first needle unit.

In the method of manufacturing a bio-information measuring apparatus according to various embodiments of the present invention, when the electrode portion is provided as the third electrode, the needle portion is formed in a working electrode region corresponding to the position of the working electrode, The biocompatible organic material in which the enzyme member and the conductive polymer are mixed or the biocompatible organic material in which the conductive polymer is mixed is injected into the counter electrode region corresponding to the position of the reference electrode, The biocompatible organic compound in which the enzyme member and the conductive polymer are mixed or the biocompatible organic compound in which the conductive polymer is mixed is injected into the reference electrode region corresponding to the second needle unit.

In the method of manufacturing an apparatus for measuring bio-information according to various embodiments of the present invention, in the step of forming the first member or the second member, the first space, the second space, The first member or the second member may be formed using at least one of electropolymerization, thermal polymerization, photopolymerization, acid polymerization, or base polymerization.

According to various embodiments of the present invention, there is provided a needle member for measuring bio-information, wherein the needle member includes a plurality of needles penetrating into a body and made of a body, the needles having an enzyme member And a biocompatible organic material mixed with a conductive polymer that transmits an electric signal generated by the reaction of the enzyme member.

In a needle member for bioinformation measurement according to various embodiments of the present invention, the needles may comprise a biocompatible organic material characterized by being connected to a working electrode.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not limited to the disclosed exemplary embodiments.

100: Biometric information measuring device 110:
120: substrate part 130: housing
140: Needle portion

Claims (27)

A biometric information measuring apparatus comprising:
A sensor unit; And
And a needle portion protruding from a plurality of openings formed on one surface of the sensor portion and having a plurality of needles penetrating into the body,
The needles,
A biocompatible organic material mixed with an enzyme member reacting with the analyte and a conductive polymer transmitting an electric signal generated by the reaction of the enzyme member.
The method according to claim 1,
Wherein the needles are formed using at least one of an electric polymerization, a thermal polymerization, a photopolymerization, an acid polymerization or a base polymerization.
The method according to claim 1,
Wherein the biocompatible organic material is further mixed with a filler.
The apparatus according to claim 1,
A substrate portion having a first space portion; And
And a housing which is stacked on the substrate and forms a second space part connected to the first space part.
The substrate processing apparatus according to claim 4,
A main board; And
And an electrode unit mounted on at least one surface of one surface or the other surface of the main substrate.
6. The method of claim 5,
The electrode unit includes:
A first electrode mounted on at least one surface of the main substrate or the other surface of the main substrate and electrically connected to the needle portion; And
And a second electrode provided on the other surface of the main substrate or the other surface and connected to an external connector terminal of the bio-information measuring apparatus.
[7] The apparatus of claim 6,
A receiving portion formed on the main substrate;
A first opening formed on the first electrode, the first opening connecting the second space and the receptacle; And
And a second opening formed on the second electrode and connected to the receiving portion, the second opening injecting the first member or the second member.
8. The method of claim 7,
Wherein the first opening and the second opening are provided with an injection port into which the biocompatible organic substance including the enzyme member and the conductive polymer is injected into the accommodation portion and a second opening through which the biocompatible organic substance including the enzyme member and the conductive polymer is injected, And a pair of exhaust ports for discharging the air of the accommodating portion are provided in each pair.
8. The method of claim 7,
Wherein the accommodating portion is provided with a reservoir.
7. The plasma display panel of claim 6,
A working electrode, and a counter electrode located around the working electrode and being a counter electrode other than the working electrode,
Wherein the biometric information measuring device is provided with the working electrode and three electrodes, which are located around the working electrode, and are a counter electrode and a reference electrode other than the working electrode.
11. The method of claim 10,
When the electrode portion is provided as two electrodes,
Wherein the needle portion protrudes from a working electrode region connected to the working electrode,
And a first needle portion connected to the counter electrode is protruded from the counter electrode region corresponding to the counter electrode position.
12. The method of claim 11,
Wherein the biocompatible organic material in which the enzyme member and the conductive polymer are mixed is molded into one body or the biocompatible organic material in which the enzyme member is mixed with the conductive polymer is molded into a body, Biometric information measuring device.
11. The method of claim 10,
When the electrode portion is provided as three electrodes,
Wherein the needle portion protrudes from a working electrode region connected to the working electrode,
The first needle portion protrudes from the counter electrode region corresponding to the counter electrode around the circumference of the working electrode region,
And a second needle portion adjacent to the working electrode region and connected to the reference electrode protrudes from the reference electrode region corresponding to the reference electrode position.
14. The method of claim 13,
The first needle portion and the second needle portion may be formed by molding the biocompatible organic material in which the enzyme member and the conductive polymer are mixed into one body or the biocompatible organic material in which the conductive polymer is mixed into a body Wherein the biometric information measuring device is characterized by:
11. The method of claim 10,
Wherein the second space portion forms a partition space of a region corresponding to the position of the working electrode and a region corresponding to a position of the electrode other than the working electrode.
16. The method of claim 15,
When the electrode portion is provided as two electrodes, the second space portion
A first compartment space provided on the first electrode, the first compartment space filled with the biocompatible organic material mixed with the enzyme member and the conductive polymer on the working electrode; And
A second compartment adjacent to the first compartment space and filled with at least one of the biocompatible organic compound in which the enzyme member and the conductive polymer are mixed or the biocompatible organic compound in which the conductive polymer is mixed, And the space is partitioned into a space.
16. The method of claim 15,
When the electrode portion is provided as three electrodes, the second space portion
A first compartment space provided on the first electrode, the first compartment space filled with the biocompatible organic material mixed with the enzyme member and the conductive polymer on the working electrode;
Wherein the biocompatible organic material mixed with the enzyme member and the conductive polymer or the biocompatible organic material in which the conductive polymer is mixed is filled in the second compartment on the counter electrode, space; And
A biocompatible organic compound in which the enzyme member and the conductive polymer are mixed or the biocompatible organic compound in which the conductive polymer is mixed is filled on the reference electrode adjacent to the first compartment space and the second compartment space And is divided into three compartment spaces.
5. The connector according to claim 4,
A first body formed on the base portion and forming the second space portion; And
And a second body formed on the first body and having the opening to be connected to the second space and fixing the plurality of needles in the first body.
A method of manufacturing a biometric information measuring apparatus,
Stacking a housing having a substrate portion having a first space portion and a second space portion connected to the first space portion on the substrate portion;
Stacking a mold part having a concave needle tip shape on the top of the housing;
An enzyme member which is provided at a lower portion of the substrate portion and reacts with the analyte through at least one opening of a pair of openings connected to the first space portion, a conductive polymer that transmits an electric signal generated by the reaction of the enzyme member Injecting a mixed biocompatible organic material in the absence of an enzyme;
Polymerizing the biocompatible organic material mixed with the conductive polymer and the enzyme member injected to the needle tip of the mold unit to form a needle unit; And
And removing the mold part. The method for manufacturing a bio-information measuring device according to claim 1,
20. The method of claim 19,
The substrate portion
A main board; And
Wherein the electrode unit is mounted on at least one surface of the main substrate or the other surface of the main substrate and is provided as one of two electrodes or three electrodes.
21. The method of claim 20,
Wherein the electrode portion includes a working electrode and a counter electrode disposed around the working electrode when the electrode portion is provided as the second electrode,
Wherein the electrode unit includes a working electrode, a counter electrode disposed around the working electrode, and a reference electrode disposed around the working electrode and at an end of the counter electrode, Wherein the biometric information measuring device comprises:
22. The method of claim 21,
And the second space part forms a respective compartment space in a region corresponding to the position of the working electrode and in a region corresponding to the position of the electrode other than the working electrode according to the second electrode or the third electrode A method of manufacturing a biometric information measuring device.
22. The method of claim 21,
When the electrode portion is provided as the second electrode,
The needle portion is formed in the working electrode region corresponding to the position of the working electrode,
And the biocompatible organic material mixed with the conductive polymer or the biocompatible organic material mixed with the enzyme member and the conductive polymer is injected into the counter electrode region corresponding to the position of the counter electrode, Wherein the biometric information measuring device comprises: 22. The method of claim 21,
When the electrode portion is provided as the third electrode,
The needle portion is formed in the working electrode region corresponding to the position of the working electrode,
Wherein the biocompatible organic material mixed with the conductive polymer and the biocompatible organic material mixed with the enzyme member and the conductive polymer is injected into the counter electrode region corresponding to the position of the counter electrode,
And the biocompatible organic material mixed with the conductive polymer or the biocompatible organic material mixed with the enzyme member and the conductive polymer is injected into the reference electrode region corresponding to the position of the reference electrode, Wherein the biometric information measuring device comprises:
22. The method of claim 21,
In the step of molding the first member or the second member,
Characterized in that the first member or the second member filled in the first space portion, the second space portion and the needle tip are molded using at least one of electropolymerization, thermal polymerization, photopolymerization, acid polymerization or base polymerization Of the living body information.
A needle member for measuring biometric information,
Wherein the needle member comprises a plurality of needles penetrating into the body and made of one body,
Wherein the needles comprise a biocompatible organic material mixed with an enzyme member that reacts with the analyte and a conductive polymer that transmits an electrical signal generated by the reaction of the enzyme member.
27. The method of claim 26,
Wherein the needle is connected to the working electrode. ≪ RTI ID = 0.0 > 21. < / RTI > A needle member for biometric information measurement comprising a biocompatible organic material.

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