KR20160065566A - Method for calculating resected and ischemized volume of renal and Program media - Google Patents

Abstract

Disclosed is a method of analyzing tumors of the kidney, which computes the volume of an area to be removed when the tumors or areas where cancer has spread are removed, and enables data regarding kidney operations to be collected later with consideration for the lost areas. The method of analyzing tumors of the kidney is performed by an analysis system that analyzes a kidney tumor image, and includes: setting a tumor area to be resected in the kidney and a suture area extended toward an outer circumferential surface of the tumor area after the tumor area is resected; setting a resection area by using the center of the tumor area as a reference point; and performing a volume integral for an area difference between the suture area and the tumor area to produce a resected and ischemized volume (RAIV) caused by excision of the tumors in the kidney.

Description

[0001] The present invention relates to a method and an apparatus for analyzing kidney tumors,

More particularly, the present invention relates to a nephron tumor analysis method and a recording medium, and more particularly, to a nephron neoplasia analysis method and a recording medium, in which nephron loss excluding tumors is determined by calculating a volume of loss accompanied by surgery when a kidney tumor is removed, The present invention relates to a method for analyzing kidney tumors and a recording medium used for tracking function.

The kidney, called the human filter, is an important organ that maintains excretion of waste products, electrolyte metabolism, and body homeostasis, and is made up of a collection of numerous nephrons. When tumors or cancer develop in these kidneys, it is necessary to remove the site, and until now, there is a side in which the metastasis of the cancer is blocked or the kidney is fully incised for definite treatment. However, kidney, which is an aggregate of nephrons, increases the loss of nephron as much as the area to be removed, so that the function of the kidney is lowered unnecessarily or the functional degeneration of the kidney after the operation is progressed.

The "R.E.N.A.L. nephrometry score: a compre- hensive standardized system for quantitating renal tumor size, location and depth." Written by Alexander Kutikov and Robert G. Uzzo in 2009. J Urol 2009; 182: 844-53. , The treatment site was performed qualitatively according to the anatomical technique of the tumor and the experience of the treatment surgeon in removing the malignant tumor of the kidney and admitted that the treatment depth and volume were not standardized at the time of the qualitative treatment have. As such, conventionally, the treatment range of the tumor or cancer formed in the kidney has been determined entirely depending on the experience of the non-standardized surgeon, that is, depending on the experience of the surgeon. It should be noted, however, that kidney organs are deteriorated as much as they are removed, and that the decrease is immediate or not.

In addition, in order to determine what kind of load is applied to the kidney by the amount extracted from the kidney, and to what extent the kidney dysfunction occurs, it is required to set the standardized extraction range and carry out analysis according to the amount of extraction.

An object of the present invention is to provide a method for analyzing kidney tumors which calculates the amount of tumor (Tumor) or cancer (Cancer) produced in the kidney and calculates an excision volume necessary for elongation analysis during renal surgery and a recording medium therefor have.

The above object is achieved by an analysis system for analyzing a renal tumor image according to the present invention, which comprises setting a tumor region to be dissected in the kidney and a sealing region extending from the incision of the tumor region toward the outer circumference of the tumor region , The incision area is set with the center of the tumor area as the reference point, and volume integration is performed with respect to the area difference between the stitching area and the tumor area, thereby calculating the loss volume (RAIV) according to the kidney tumor extraction do.

According to the present invention, said object is achieved by an analyzing apparatus comprising a processor and a memory, comprising the steps of: setting a central portion of a kidney tumor region as a reference point in a kidney tumor image; After the incision, setting a stitching area extending from the outer periphery of the tumor area, performing volume integration on the area corresponding to the area difference between the stitching area and the tumor area around the reference point to calculate the loss volume of the kidney tumor And a recording medium having a program for performing the steps.

Here, the loss volume RAIV can be calculated according to the following equation.

,

,

here,

Π is the circumference, W is the distance between the incision area and the stapled area, and r is the length from the center of the tumor area to the incision area.

According to the present invention, when a tumor or cancer site is removed from the kidney, the volume to be removed is calculated, and data related to kidney operation can be accumulated with reference to the loss area later removed from the kidney.

1 is a conceptual diagram of a method for analyzing kidney tumors according to an embodiment of the present invention.
Fig. 2 shows a procedure in which a tumor is formed on one side of the kidney and the tumor is removed.
Figure 3 shows a cross-sectional view of the incised tumor and a reference for subsequent treatment.
4 shows a conceptual diagram of a method for calculating the RAIV volume according to an embodiment.

The tumor (Tumor) and cancer (Cancer) referred to in the present specification are classified according to invasion and metastasis. Cancer is also one of the tumors. Can be applied equally. Therefore, it should be noted that, in the present specification, either tumor or cancer, even if not mentioned separately, is an analytical method that is equally applied to both.

The tumor region referred to herein refers to a region in which a tumor (or cancer) is distributed in the kidney, or to a region including a region to be further treated by the surgeon in addition to the distribution region of the tumor (or cancer) . Note that when a surgeon removes a tumor (or cancer), the surrounding area may be further cut without precisely cutting the area.

The renal tumor assay method referred to herein can be implemented as a program medium that processes each step. In this case, the method for analyzing kidney tumors according to the embodiment may be implemented in the form of a program running on a computing device having a processor and a memory, and applicant claims program recording medium therefor.

Hereinafter, the present invention will be described in detail with reference to the drawings.

FIG. 1 shows a conceptual view of a method for analyzing kidney tumors according to an embodiment of the present invention, FIG. 2 shows an embodiment of dissecting a tumor in the kidney, and FIG. 3 is a cross- And FIG. 4 shows a conceptual diagram of a method of calculating the RAIV volume according to the embodiment.

Hereinafter, a description will be given with reference to Figs. 1 to 4 together.

The method for analyzing kidney tumors according to an embodiment is performed by an analysis system 10 having a processor and a memory, and the analysis system 10 includes an input device such as a display device for analyzing data or a keyboard, a mouse, and a trackball can do. The analysis system 10 can acquire and use the tumor image 5 for Kidney through a diagnostic device such as a computed tomography (CT) device or a magnetic resonance imaging (MRI) device. The analysis system 10 can set a reference point RP at the center of the tumor in the tumor image 5, where the reference point RP can be set at the center of the circle, assuming the tumor is a circle. After setting the reference point, the analysis system 10 sets the quadrant by forming the X-axis and the Y-axis at the center of the tumor, and sets the stitch area 102 and the tumor area 101, which are expressed in the quadrant, Can be regarded as a function. The analysis system 10 then generates a function for the closure region 102 and a function for the tumor region 101 and can perform volume integration taking the extraction depth w into account for the generated function. At this time, the volume integration may correspond to the difference volume between the suture area 102 and the tumor area 101. This difference volume determines the volume of the RAIV lost by the suture after the operation by the surgeon, It is possible to determine objectively and quantitatively the degree of blood loss, loss time, and damage of kidney tissue.

On the other hand, the setting of the reference point RP is set at the center of the tumor 21 after assuming a contact surface area (CSA) of a circle as a circle, 22) to follow the procedure. This will be described with reference to FIG. 2 and FIG.

Fig. 2 shows a procedure in which a tumor 21 is formed on one side of the kidney 20 and the tumor is removed. In Figure 2, a surgeon cuts the tumor 21 using a scalpel 30 (or a laser, not shown), where the incision area is cut off by spooning the inside of the kidney 20 .

3, the incised region is recessed inside the kidney 20, and the outer circumferential edge of the recessed region is located between the needle 30 and the suture 30, As shown in Fig. In this case, the area S2 to be sealed with the needle 40 by the suture is a sealing area. Nephron located in the sealing area S2 is used for sealing the wound area, .

Therefore, the sum of the suture area S2 and the tumor area S1 removed from the kidney 20 corresponds to the area to be removed, and the area to be removed is the area where the function of the kidney dysfunction or the kidney of the patient is degenerated after the operation of the surgeon Level.

The applicant of the present invention intends to mathematically propose a range to be extracted when the tumor 21 formed in the kidney 20 is extracted. The proposed mathematical model is used to minimize the burden on the kidney 20, And to suggest an incision range. This will be described with reference to FIG.

4 shows a conceptual diagram of a method for calculating the RAIV volume according to an embodiment. Referring to FIG. 4, reference numeral 21 designates a tumor, and the volume of the RAIV (Resected And Ischemized Volume) is represented by the sum of the R3 region and the R4 region. Here, the R3 area corresponds to the area removed by the surgeon, that is, the Resected Volume, and the R4 area corresponds to the area to be sutured, i.e., Ischemized Volum, after being removed by the surgeon. The sum of the Resected Volume and the Ischemized Volum corresponds to the total volume of the nephron substantially removed from the kidney after the procedure and is referred to herein as the RAIV volume. For the calculation of the RAIV volume, the analysis system 10 can set a reference point RP for the tumor image 5. The setting of the reference point RP can be set at the central portion of the tumor 21 in the tumor image 5 and is not normally extracted along the layout of the tumor 21 when the tumor 21 is extracted. The surgeon treats the tumor 21 as a point or a circle and incisions the tumor 21 or the tumor and its surroundings for the definitive removal of the tumor and removal of the remaining tumor.

After setting the plane of the tumor 21 to a circular shape in the tumor image 5, the tumor region 101 is set up to the peripheral region to be removed including the tumor 21 or the tumor 21, When the area to be stitched after being removed by the surgeon is set as the stitching area 102, the reference symbol "w" corresponds to the distance between the tumor area 101 and the stitching area 102, And corresponds to the radius of the tumor region 101.

At this time, the analysis system 10 sets the reference point RP at the center of the tumor region 101. As the reference point RP is set at the center of the tumor region 101, Quadrant. As the tumor region 101 is partitioned by the quadrant, the tumor region 101 may form a function graph with the reference point RP as the center coordinate, as shown in Figure 4, Has a parabolic shape symmetrical on the reference point. The reference line RL shown on the right side of the reference point RP in the drawing corresponds to a region to be cut by the surgeon in consideration of the depth of the tumor region 101. [ The right region of the incision 103 represents the depth (d) at which the surgeon removes the tumor region 101 and is extracted. That is, reference numeral "d" corresponds to the depth at which the incision 103 extends into the kidney 20 and the tumor region 101 should be extracted on the front view of Fig. When the expected loss volume RAIV according to the procedure is calculated based on the above description,

RAIV is formed around the reference point RP and is defined by the formula of the parabola formed by the outer circumference of the seal region 102 on the quadrant represented by the X axis and the Y axis and the outer circumference of the tumor region 101 . When the X axis is formed around the reference point RP, the X axis coordinate of the sealing region 102 is X 'and the X axis coordinate of the tumor region 101 is X, the sealing region 102 and the tumor The parabolic formulas for each of the regions 101 are as shown in Equations (1) and (2) below.

After calculating the functions for the septal region 102 and the tumor region 101 through equations (1) and (2), the extraction depth (w) is calculated for each of the functions of Equations (1) and When the volume of the region 102 and the tumor region 101 are obtained, the following equations (3) and (4) are obtained.

(3) and (4), the volume was calculated by taking the extraction depth (w) for the stitching area and the tumor area, respectively. Since the RAIV volume corresponds to the difference volume for V 'and V, the RAIV volume is developed as shown in Equation 5 below.

The volume V 'is the integral of the function of equation (1) over the interval r + d, and the volume v is the function of the equation (2) divided by the ratio rd To r. The RAIV volume in Equation (5) can be summarized as Equation (6) below.

The RAIV volume derived from the mathematical expression is regarded as a function placed in the quadrant centered on the reference point RP as the suture region 102 and the tumor region 101 and the volume difference Was performed to calculate the nephron loss volume of the elongation along the seam region 102. Since the nephron of tumor area 101 does not function as part of the kidney, it can be seen that the RAIV volume corresponds to the pure loss volume extracted by the surgeon.

The RAIV volume algorithm computed from Equations 1 through 6 above functions as a function of the treatment range of the kidney 20 using the tumor image 5 and allows the surgeon to determine the RAIV volume lost by his / So that it can be judged. Until now, it has been difficult for a surgeon to clearly determine how much RAIV volume loss occurs when the tumor 21 formed on the surface of the kidney 20 is removed. Thus far, the method of measuring the RAIV volume , But it has been determined by the experience of the surgeon.

The present invention provides an objective indicator for determining how much renal tissue damage occurs, how much bleeding occurs, and how long it takes the surgeon to remove the tumor area 101 . In addition to the surgical procedure performed by the surgeon directly, the same procedure is applied to the PN procedure using the robot. The surgeon performs preoperative operation using the CSA of the kidney (20) and the depth (W) of the tumor It is possible to refer to the calculated RAIV volume so that it can be performed. The performance of the operation for extracting the tumor 21 by receiving the RAIV volume will be described with reference to FIG.

10: Analysis System 20: Kidney
21: tumor R3: Resected Volume
R4: Ischemized Volum 101: Tumor area
102:

Claims (6)

Is performed by an analysis system for analyzing kidney tumor images,
A tumor region to be dissected from the kidney, and a sealing region extending from the incision of the tumor region toward an outer periphery of the tumor region,
Wherein an incision region is set with the center of the tumor region as a reference point and volume integration is performed with respect to an area difference between the stitching region and the tumor region to calculate a loss volume (RAIV) according to the kidney tumor excision Kidney tumor analysis method. The method according to claim 1,
The loss volume (RAIV)
The method according to any one of claims 1 to 3,

,
here,
Π is the circumference, W is the distance between the incision area and the stapled area, and r is the length from the center of the tumor area to the incision area. The method according to claim 1,
The loss volume (RAIV)
Wherein the tumor is a volume for a non-tumor region extending from the rim of the tumor to the rim of the stitching region. The method according to claim 1,
The reference point,
Wherein the center of the circle is set at a center of the circle after the incision region is assumed to be a circle. A processor and a memory,
In a renal tumor image, setting a central portion of a kidney tumor region as a reference point;
Setting a stitching area to be incised in the kidney and a stitching area extending to an outer periphery of the tumor area after incision of the tumor area; And
Performing volume integration on a region corresponding to a difference in area between the stitching region and the tumor region about the reference point to calculate a loss volume of the kidney tumor. 6. The method of claim 5,
The loss volume (RAIV)
Wherein the program is calculated according to the following equation: < EMI ID =

,
here,
Π is the circumference, W is the distance between the incision area and the stapled area, and r is the length from the center of the tumor area to the incision area.

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