KR20160056130A

KR20160056130A - Balloon for obesity therapy

Info

Publication number: KR20160056130A
Application number: KR1020140156137A
Authority: KR
Inventors: 전훈재; 금보라; 김은선; 최혁순; 유인경; 이재민; 김승한; 남승주; 홍정화; 설동근; 이정주
Original assignee: 고려대학교 산학협력단
Priority date: 2014-11-11
Filing date: 2014-11-11
Publication date: 2016-05-19

Abstract

The present invention relates to an intragastric balloon for obesity therapy, wherein the balloon comprises: an outer skin unit capable of expanding to create an inner space in response to a fluid supplied therein; and a wall unit which partitions the inner space of the outer skin unit into multiple separate spaces, wherein the separate spaces partitioned by the wall unit are alternately filled with fluids having different densities from each other while expanding the outer skin unit. Accordingly, the present invention can prolong the lifespan of the balloon being inserted into the body for obesity therapy and minimize damage to the gastric wall.

Description

A balloon for treating obesity {BALLOON FOR OBESITY THERAPY}

The present invention relates to a balloon for treating obesity, and more particularly, to a balloon for treatment of obesity that can prolong the life of the balloon inserted in the stomach for minimizing obesity and minimize damage to the stomach wall.

Recently, modern people have a small amount of activity, but the amount of calories consumed through food increases the probability of developing into obesity. Particularly, passive living through various audiovisual media such as computers, portable terminals, and televisions is mainstream, and therefore, the probability of being connected to obesity is increasing as the time for sitting and living increases rather than exercising by using the body.

There are various ways to treat such obesity.

For example, exercise or diet therapy is used, which is mostly recognized by the general public. Exercise and dietary methods can be a simple way of reducing dietary intake by increasing calorie consumption by exercising on the basis of the pathophysiology of obesity accumulated in the body when the caloric intake exceeds the consumption. However, such a method is well known to the general public, but it requires constant effort and patience, and most obesity patients do not practice it in their lives. Especially, in the case of high obesity patients, it is difficult to perform this method there is a problem.

One of the other methods for treating obesity is drug therapy using drugs. Xenical and Reductil have been approved by the US FDA for the treatment of obesity. Xenical is a drug that inhibits absorption of fat in the intestines. . However, there is an inconvenience that it should be taken all the time after ingesting food, In addition, there is a problem that the effect disappears when the drug is stopped, and the fact that the verification of the side effects of the drug has not yet been completed is also recognized as a problem.

Reductil is a drug that inhibits the appetite center of the brain and reduces the appetite of the patient to induce weight loss. It is easy to take only once a day, and there is no side effects such as Xenical. However, this drug itself is a kind of psychotropic medicines, which may have side effects, and it may cause chronic appetite deterioration or cause abnormalities in the body upon chronic administration.

Another method of treating obesity is surgical treatment, ie, surgery, which has recently been performed for obese adults. It is based on the principle that abdominal or laparoscopic surgery is used to abolish the two principles, that is, the ablation of a portion of the stomach to reduce the stomach volume, followed by early satiety and eating restriction to reach weight loss, It is based on the principle that weight loss is reached. However, these procedures are very invasive and there is a risk of surgery, and it is impossible to reconstruct them once they are done.

As another example, one of the endoscopic obesity treatments is to insert a balloon on the endoscope. Korean Patent Laid-Open Publication No. 10-2006-0024692 discloses an example of a procedure for inserting a balloon into the stomach.

In recent years, a product with a technique of inserting a balloon inside the stomach has been applied to the actual procedure. In the US, Ellergan's orbera / BIB is used to inflate a patient's body mass index (BMI) of 27 or more into a balloon infusion of 400-700 ml of physiological saline to a size of about 13.5 cm. Although the effect of reducing the excess weight by 32.1% was found within 6 months, side effects such as gastritis were also reported due to the friction between the balloon and the stomach wall. In addition, products that inject air into the balloon have been applied to the actual procedure, but the same side effects as Orbera / BIB occur.

The side effect of the balloon inserted on the balloon is to maintain the volume of the balloon by the saline solution or air or the like inserted into the balloon in order to maintain the volume of the balloon inserted thereon. And other parts of the balloon that are not in contact with the balloon are more likely to be exposed to stomach acid.

That is, if only a specific surface of the balloon is continuously exposed to gastric acid, the surface of the balloon reacts with the acid, resulting in shortening the life of the balloon. On the other hand, if the balloon is stably positioned in the stomach, the balloon contacts only in a specific area of the stomach wall, thereby increasing the probability of causing inflammation by damaging the stomach wall of the stomach.

Thus, in the case of a balloon inserted in the stomach, a certain degree of movement may be desirable to increase the life of the balloon and to minimize damage to the stomach wall. It would also be desirable to minimize the damage of the stomach wall by balloons through other methods.

SUMMARY OF THE INVENTION Accordingly, the present invention has been made in order to solve the above-mentioned problems, and provides a balloon for treating obesity, which can prolong the life of the balloon inserted in the stomach for minimizing obesity, There is a purpose.

According to the present invention, there is provided a balloon for treating obesity, comprising: an outer skin which is expanded in accordance with a supply of a fluid therein to form a space therein; and a partition wall partitioning the inner space of the outer skin into a plurality of divided spaces &Lt; / RTI > Wherein the outer skin is inflated in a state in which the fluids having different densities are injected into the plurality of divided spaces divided by the partition part.

Here, the partition wall part may divide the inner space of the outer skin evenly in the vertical direction to form the plurality of divided spaces, or may divide the inner space of the outer skin evenly in the vertical direction and the horizontal direction, Can be formed.

In addition, the fluid of differing densities may comprise water and air.

The plurality of divided spaces may be divided into a plurality of first divided spaces into which one fluid is injected and a plurality of second divided spaces into which the other fluid is injected; A first injection port for injecting one fluid into the first divided space and a second injection port for injecting another fluid into the second divided space.

In addition, the plurality of first divided spaces may communicate with each other, and the first inlet may be provided on the outer skin so as to communicate with any one of the plurality of first divided spaces, Respectively, into a plurality of first divided spaces; Wherein the plurality of second divided spaces communicate with each other and the second injection port is provided on the outer skin so as to communicate with any one of the plurality of second divided spaces, Respectively, into the second divided space of FIG.

The outer skin may be made of polyurethane.

In addition, the outer surface of the outer skin may be coated with an ulcerative therapeutic agent and a biocompatible polymer.

According to the present invention, there is provided a balloon for treating obesity, which can prolong the life of the balloon inserted into the stomach for minimizing obesity and minimize damage to the stomach wall.

FIG. 1 is a view showing a use state of a balloon for treating obesity according to the present invention,
FIG. 2 is a view for explaining a balloon for obesity treatment according to the first embodiment of the present invention,
FIG. 3 is a view for explaining a balloon for obesity treatment according to the second embodiment of the present invention,
4 to 6 are views for explaining a balloon for obesity treatment according to the third embodiment of the present invention,
7 is a view for explaining a balloon for obesity treatment according to the fourth embodiment of the present invention,
8 is a view showing a configuration of a first injection port and a second injection port of a balloon for obesity treatment according to the present invention.

Hereinafter, embodiments according to the present invention will be described in detail with reference to the accompanying drawings.

As shown in FIG. 1, the balloon 1 for obesity treatment according to the present invention is placed in the stomach S in a state of being inflated to a certain volume after being injected into the stomach S of the patient, (S) < / RTI > volume of the patient.

2 is a view for explaining a balloon 1 for obesity treatment according to the first embodiment of the present invention. Referring to FIG. 2, the balloon 1 according to the first embodiment of the present invention includes an outer skin 10 and a partition 30.

The outer skin (10) expands according to the supply of the fluid therein, and a space is formed therein. The partition wall portion 30 divides the inner space of the outer skin 10 into a plurality of divided spaces 51 and 52.

More specifically, the partition 30 is provided inside the outer skin 10, and divides the inner space of the outer skin 10 into a plurality of divided spaces 51 and 52. In FIG. 2, it is exemplified that the partition wall 30 equally divides the inner space of the outer skin 10 into four divided spaces 51 and 52 in the vertical direction to form four divided spaces 51 and 52 have.

The outer skin 10 is inflated in the divided spaces 51 and 52 divided by the partition 30 in a state in which fluids having different densities are injected at intersections. 2 (b) is a cross-sectional view taken along the line A-A in Fig. 2 (b). As shown in FIG. 2 (b), fluids having different densities are injected into the four divided spaces 51 and 52 at an intersection to swell the outer skin 10.

In the present invention, water (or saline) and air are applied to fluids of mutually different densities injected into the divided spaces 51 and 52. Accordingly, the four divided spaces 51 and 52 are divided into a divided space 51 into which water is injected and a divided space 52 into which air is injected.

According to the above configuration, when the balloon 1 according to the present invention is placed inside the stomach S of the patient, the weight in the same volume varies depending on the density of water and air, S of the balloon 1 can be made more smooth.

Therefore, it is possible to minimize the shortening of the service life of the balloon 1, which occurs as the specific position of the balloon 1 is continuously exposed to the stomach acid while the movement of the balloon 1 is small. In addition, the smooth movement of the balloon 1 minimizes the continuous stimulation of the balloon 1 at a specific position of the stomach wall, thereby minimizing the occurrence of side effects such as gastritis.

Here, the outer skin 10 is made of a polyurethane material which is a biocompatible material. In addition, the outer surface of the outer skin 10 may be coated with an ulcerative therapeutic agent, such as omeprazole and a biocompatible polymer such as PLG, PLGA, PGA.

Thus, the ulcerative therapeutic agent acts on the damage of the gastric wall caused by the contact of the outer skin 10 with the gastric wall through the ulcerative therapeutic agent coated on the outer skin 10, so that the gastric wall damage of the patient can be minimized do.

3 is a view for explaining a balloon 1a for obesity treatment according to a second embodiment of the present invention. In the embodiment shown in FIG. 3, the partition wall 30a divides the inner space of the outer skin 10a into eight divided spaces 51a and 52a in the vertical direction.

3 (b) is a cross-sectional view taken along the line B-B in Fig. 3 (a). The eight divided spaces 51a and 52a partitioned by the partition 30a are divided into a divided space 51a into which water is injected and a divided space 52a into which air is injected. As shown in the figure, the partitioning space 51a into which water is injected and the partitioning space 52a into which air is injected are formed as an intersection.

4 to 6 are views for explaining a balloon 1b for obesity treatment according to a third embodiment of the present invention. 4 to 6, in the third embodiment of the present invention, the partition walls 30b and 31b divide the inner space of the outer skin 10b evenly in the vertical direction and the horizontal direction, (51b, 52b) are formed.

FIG. 5 is a view showing only the partitions 30b and 31b from which the outer skin 10b is removed from the balloon 1b according to the third embodiment of the present invention. 5, the barrier ribs 30b and 31b include a vertical barrier rib 30b formed in a vertical direction and a horizontal barrier rib 31b formed in a horizontal direction, and two vertical barrier ribs 30b intersect with each other and the horizontal partition 31b is vertically bisected vertically in the horizontal direction to form eight divided spaces 51b, 52b.

In this case, water and air are injected into the eight divided spaces 51b and 52b in such a manner that water and air are injected to the lower divided spaces 51b and 52b with reference to the horizontal partition wall portion 31b, The divided space 51b into which the air is injected and the divided space 52b into which the air is injected are formed in an intersecting manner and the divided spaces 51b and 52b in which water is injected into the upper divided spaces 51b and 52b with reference to the horizontal partition wall portion 31b, And a divided space 52b into which the air is injected. At this time, different fluids may be injected into the upper and lower adjacent divided spaces 51b and 52b.

FIG. 7 is a view for explaining a balloon 1c for obesity treatment according to a fourth embodiment of the present invention, in which the inner space of the outer skin is divided into 16 divided spaces As shown in Fig.

Meanwhile, the balloon 1 for treating obesity according to the present invention may include a first injection port 71 and a second injection port 72, as shown in FIG. 8 shows an example in which the first injection port 71 and the second injection port 72 are formed in the balloon 1 according to the first embodiment of the present invention. However, in the same technical idea, It goes without saying that the first injection port 71 and the second injection port 72 may be formed in the embodiment as well.

As described above, the plurality of divided spaces 51 and 52 are divided into a divided space 51 (hereinafter, referred to as a 'first divided space 51') into which one fluid of different fluid is injected, (Hereinafter, referred to as a 'second partition space 52') into which fluid is injected.

The first injection port 71 is provided in the first subdivided space 51 such that a corresponding fluid such as water can be injected and the second injection port 72 is provided in the second subdivided space 52 with a corresponding fluid, Injectable.

The fluid is not injected into the first and second divided spaces 51 and 52, that is, the inflated balloon 1 is injected into the stomach S of the patient, S, the water is injected into the first injection port 71 through an injection tube (not shown), and the outer skin 10 is inflated by injecting air through the second injection port 72.

Here, various known methods can be applied to the structure of the first inlet 71 and the second inlet 72 and the structure of injecting water or air through the first inlet 71 and the second inlet 72, and detailed description thereof will be omitted herein.

The plurality of first dividing spaces 51 are formed so as to communicate with each other and are provided on the outer skin 10 so that one first inlet opening 71 communicates with any one of the plurality of first dividing spaces 51, The fluid to be injected through the first injection port 71 can be injected into all of the plurality of first partitioning spaces 51.

Likewise, the plurality of second divided spaces 52 are formed so as to communicate with each other, and one second inlet 72 is provided in the outer skin 10 so as to communicate with any one of the plurality of second divided spaces 52, The fluid to be injected through the second injection port 72 can be injected into all of the plurality of second partition spaces 52.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to be exemplary and explanatory only and are not to be construed as limiting the scope of the inventive concept. And it is obvious that it is included in the technical idea of the present invention.

1, 1a, 1b, ac: balloon 10, 10a, 10b, 10c:
30, 30a, 30b, 30c:
51, 51a, 51b, 51c, 52, 52a, 52b, 52c:
71: first inlet port 72: second inlet port

Claims

In balloons for the treatment of obesity,
An outer skin which expands according to the supply of the fluid to form a space therein,
And a partition wall partitioning the inner space of the outer skin into a plurality of divided spaces;
Wherein the outer skin is inflated in a state in which fluids of mutually different densities are injected into the plurality of divided spaces divided by the partition part.

The method according to claim 1,
The partition wall portion
The inner space of the outer skin is divided equally in the vertical direction to form the plurality of divided spaces,
Wherein the inner space of the outer skin is equally divided in the vertical direction and the horizontal direction to form the plurality of divided spaces.

The method according to claim 1,
Characterized in that the fluid of mutually different densities comprises water and air.

The method according to claim 1,
Wherein the plurality of divided spaces are divided into a first plurality of divided spaces into which one fluid is injected and a plurality of second divided spaces into which the other fluid is injected;
Further comprising a first injection port for injecting one fluid into the first divided space and a second injection port for injecting another fluid into the second divided space.

5. The method of claim 4,
Wherein the plurality of first divided spaces communicate with each other, and the first injection port is provided on the outer skin so as to communicate with any one of the plurality of first divided spaces, and one fluid injected through the first injection port Respectively, into the first divided space;
Wherein the plurality of second divided spaces communicate with each other and the second injection port is provided on the outer skin so as to communicate with any one of the plurality of second divided spaces, Wherein the balloon is infused into the second divided space of the balloon.

The method according to claim 1,
Wherein the outer skin is made of a polyurethane material.

The method according to claim 6,
Wherein the outer surface of the outer skin is coated with an ulcerative therapeutic agent and a biocompatible polymer.