KR20160030155A - Method for providing optimal guiding index on cornea implant with user orientation - Google Patents

Abstract

A method for providing a user-oriented corneal implant index of the present invention comprises: an information input step of inputting eyesight information of a subject for surgery and scanning data of corneal width and thickness from one or more measurement devices; a corneal information generation step of parsing the scanning data of corneal width and thickness to generate connection numerical information, which corresponds to information about corneal depth data by corneal width of the subject for surgery; a numerical calculation step of generating guiding index information, which corresponds to data about the correlation between width and depth of a corneal fragment for inserting a corneal implant, using the connection numerical information; and a main control step of controlling to output the guiding index information through a screen display unit such that guiding index information corresponding to expressions, Tx0.3<=D and T-D>=Tx0.6, and guiding index information not corresponding thereto are displayed in a differential manner.

Description

Technical Field [0001] The present invention relates to a corneal implant index,

The present invention relates to a method of providing a guiding index for corneal implant surgery, and more particularly, to minimizing the human-dependent factor in performing corneal implant surgery, The present invention also relates to a method for providing a user-oriented corneal implant index that can be optimized for an individual patient by reflecting characteristic information of each individual patient as well as improving the success rate of vision recovery and maintenance of visual acuity.

The most commonly used method for correcting or improving vision is called laser in situ keratomileusis (LASIK) or laser assisted sub-epithelial keratomileusis (LASEK). Although the above-described operations have their own characteristics, they can be said to be vision correction or correction surgery for correcting myopia, hyperopia or astigmatism by cutting a certain portion of the cornea using various lasers.

In addition to this method, a corneal implant surgery for inserting a lens having a physical or chemical property similar to that of a real cornea has been disclosed. The lens used for the corneal implant surgery has a similar water content to the actual cornea, It has recently attracted attention as it has a corresponding refractive index and is biocompatible as well as it has few side effects of surgery and can maintain a healthy corneal state even after the operation.

However, since the conventional corneal implant surgery is performed using only uniform reference values and numerical values without reflecting the inherent characteristics of individual patients, it is difficult to obtain optimized results according to individual characteristics, , And the depth of insertion of the corneal implant depends heavily on the subjective factors such as the physician's intuition and experience, which may hinder the stability of the operation and make it difficult to achieve optimized results for vision recovery .

Korean Patent Laid-Open Publication No. 10-2014-0079852 discloses an apparatus for monitoring surgical parameters, but this document discloses only complex image analysis techniques for determining parameters of the human eye using image information And is used only for determination of specific parameters in the localized part, and the above-mentioned problem can not be solved.

SUMMARY OF THE INVENTION The present invention has been made to solve the above problems, and it is an object of the present invention to provide infra data which can sufficiently guide the unique characteristics of the cornea for each operation subject, In addition to providing the guiding index for surgery through the data processing that correlates the characteristic data of the operation subject and the important parameters for performing the surgery, it is possible to minimize the physician's dependent factors, The present invention provides a method of providing a user-oriented corneal implant index so that optimized corneal implant surgery can be performed.

Other objects and advantages of the present invention will become apparent from the following description, and it will be apparent from the description of the embodiments of the present invention. Further, the objects and advantages of the present invention can be realized by a combination of the constitution shown in the claims and the constitution thereof.

According to another aspect of the present invention, there is provided a method of providing a user-oriented corneal implant index, comprising: inputting scanning data on visual acuity information, corneal width and thickness of a subject to be operated from one or more measurement devices; Generating corneal information by parsing scanning data on the corneal width and thickness to generate linkage numerical information which is depth data of the cornea according to corneal width of the operation subject; A numerical computation step of generating guiding index information, which is data on a correlation between a width and a depth of a corneal flap for insertion of the corneal implant, using the linked numerical information; And a main control step of outputting the guiding index information to the screen display means so that guiding index information corresponding to all of the following equations and guiding index information not corresponding to the guiding index information are displayed in a differential manner have.

In the above equation, T is the corneal thickness information of the subject, D is the depth information of the corneal flap in the guiding index information, and (T-D) is the remaining corneal thickness information.

Further, in the information input step of the present invention, the personal information including the age information of the operation subject can be further input. In this case, in the main control step of the present invention, Is further output.

In the above equation, T is the corneal thickness information of the operation subject, R is the corneal degeneration degree coefficient, Y is the current age information of the operation subject, y is the age degeneration coefficient, and K is the effective standard duration for the correction of the corneal implant.

For the implementation of the further preferred embodiment, the main control step of the present invention is configured to output the guiding index information in combination with the input interface environment. In this case, the specific guiding index information is selected And outputting the selected guiding index information to the laser device for forming a corneal flap.

Further, in the main control step of the present invention, it is preferable to calculate the estimated value of the effective visual acuity duration by the cornea implant according to the following equation, and further output it.

Estimate information about the Formula S are valid for eye duration in, T is the corneal thickness information of the operation target person, D _max is the maximum depth information of a corneal flap, D _min is the minimum depth information of a corneal flap, R is corneal degeneration coefficients, Y is the current age information of the operation subject, y is the age degeneration coefficient, and G is the minimum effective vision duration information.

According to a preferred embodiment of the present invention, guiding information on the position where the corneal implant is inserted, that is, the depth of the corneal flap formed for insertion of the implant, is accurately generated and provided using unique corneal characteristic information for each patient And thus it is possible to minimize the dependency factor of the surgical execution and to optimize the corneal implant surgery to the characteristics of the patient.

In addition, according to a preferred embodiment of the present invention, it is possible to precisely distinguish the corneal implant surgery from the case where corneal implant surgery is possible or not, and precisely provide a thickness information range of the corneal flap that can be operated, So that it is possible to further improve the precision and accuracy of the operation.

It is possible to provide various data on the result of the corneal implant surgery and the like to be provided to the operation subject and provide an advantage that it can be more advantageous in meeting the patient's right to know.

BRIEF DESCRIPTION OF THE DRAWINGS The accompanying drawings, which are incorporated in and constitute a part of the specification, illustrate preferred embodiments of the invention and, together with the detailed description of the invention given below, serve to better understand the technical idea of the invention, And shall not be construed as limited to such matters.
1 is a block diagram showing a detailed configuration of an apparatus and a system for providing a user-oriented corneal implant index according to a preferred embodiment of the present invention;
FIG. 2 is a flowchart illustrating a process for providing a user-oriented corneal implant index according to an exemplary embodiment of the present invention. FIG.
FIG. 3 is a flowchart illustrating a process for providing a user-oriented corneal implant index according to another preferred embodiment of the present invention. FIG.
FIG. 4 is a 3D and 2D schematic diagram of thickness and width of a cornea for calculating association numerical information or guiding index information according to a preferred embodiment of the present invention. FIG.
5 is a cross-sectional view showing a correlation between the insertion position of the corneal implant and the thickness of the cornea,
6 is a view illustrating human information or vision information of a subject to be operated,
7 is a diagram illustrating an environment in which data on the guiding index and the residual corneal thickness for the surgical correction range are differentially expressed,
8 is a diagram illustrating an environment in which the index selected by the final guiding index is displayed differentially.

Hereinafter, preferred embodiments of the present invention will be described in detail with reference to the accompanying drawings. Prior to this, terms and words used in the present specification and claims should not be construed as limited to ordinary or dictionary terms, and the inventor should appropriately interpret the concepts of the terms appropriately It should be construed in accordance with the meaning and concept consistent with the technical idea of the present invention based on the principle that it can be defined.

Therefore, the embodiments described in the present specification and the configurations shown in the drawings are merely the most preferred embodiments of the present invention and are not intended to represent all of the technical ideas of the present invention. Therefore, various equivalents It should be understood that water and variations may be present.

1 is a block diagram showing a detailed configuration of an apparatus and a system 100 for providing a user-oriented corneal implant index according to a preferred embodiment of the present invention (hereinafter referred to as a "providing system"). 1, the providing system 100 of the present invention includes a surgery information input unit 110, a cornea information generating unit 120, a numerical operation unit 130, a main control unit 140, a screen display unit 150, A second input unit 160, an alarm unit 170, and a storage unit 180.

Prior to the detailed description, each component of the providing system 100 according to the present invention shown in FIG. 1 should be understood as a logically distinct component rather than as a physically distinct component.

That is, since each constitution corresponds to a logical constituent element for realizing the technical idea of the present invention, even if each constituent element is constituted integrally or separately, if the function performed by the logical constitution of the present invention can be realized, It is to be understood that any component that performs the same or similar function should be interpreted as falling within the scope of the present invention regardless of the consistency of the name.

The surgical information input unit 110 of the present invention may be configured to receive information from the at least one measurement device including the visual acuity measuring device 51 and the cornea information measuring device 53 such as the visual acuity information of the subject of corneal implant surgery And the thickness of the cornea (S200).

Corneal implant surgery is a procedure of correcting or restoring visual acuity by inserting an implant (a kind of lens) into a cornea of a human. The corneal implant surgery procedure according to the present invention will be briefly described as follows. First, through the method of the present invention as described below, precise and accurate judgment is made as to whether or not the surgical client has appropriate corneal environment and conditions for surgical operation and a guiding numerical value range which is an optimization condition of surgery.

If it is judged that surgery can be performed, a corneal flap is formed by cutting a part of the cornea using a laser, and the formed flap is formed so as to be precisely based on the guiding numerical value, which is an optimal condition for surgery. The success rate can be further improved.

Once the slice is formed according to precisely quantified criteria, the formed slice is lifted, and the corneal implant is positioned at the center of the pupil lifted by the corneal flap and covered with the lifted cornea flap. Thereafter, the surgical procedure is completed by performing appropriate post-operative treatment to ensure that the corneal implant is accurately positioned.

On the other hand, a human's cornea generally has a hemispherical shape, but various factors such as the thickness of the cornea, the shape of the cornea, and the radius of the cornea are not equal to each other due to inherent biological characteristics.

Of course, it is possible to perform corneal implant surgery based on the statistical reference value, provided that the characteristics of each person are not large. However, in this case, since the characteristics unique to each person are not reflected, It becomes difficult to perform implant surgery.

In order to solve the above-mentioned problem, the cornea information generator 120 of the present invention analyzes the corneal width and the thickness of the operation subject through the operation information input unit 110, Which is depth data of the cornea according to the width of the cornea of the cornea (S210).

When the linked numerical information is generated, the numerical operation unit 130 of the present invention generates guiding index information, which is data on the correlation between the width and the depth of the corneal flap for insertion of the corneal implant using the linked numerical information (S220).

(Depth) and thickness (depth) of the cornea, which are unique to each person, by using a device or a scanning device for measuring the thickness or width (diameter) of the cornea, ) Information and the like can be generated.

D1, D2, D3, D4 and D5 mean the thickness (depth) of the corneal flap toward the inside of the cornea on the basis of the external reference, and L1 , L2, L3, L4 and L5 denote the cornea width at the corresponding thickness (depth) point. In the description of the present invention, the linked numerical information can be defined as a correlation between the depth data information and the width of the cornea according to the width and the corneal depth.

Thus, using the scanning data, it is possible to generate unique corneal characteristic information for each operation subject, and by using this directly for corneal implant surgery, more precise and accurate operation becomes possible.

When linkage numerical information is generated, guiding index information, which is data on the correlation between the width and the depth of the corneal flap for insertion of the corneal implant, is generated using the parameter information to be used in actual surgery.

The related numerical information and the guiding index information generated by using the related numerical information according to the resolution (resolution) of the scanning equipment, the capacity of the hardware resource, the efficiency of the data processing, and the like can be generated at finer intervals. It is needless to say that one or more linked numerical information and guiding index information may be generated between sampled unit intervals through a mathematical operation using the above-mentioned mathematical operation.

As shown in FIG. 5, the corneal implant 30 forms a section on the outer skin of the cornea (the epithelium 21, the parenchyma 23), and is located at the position where the section is lifted. Therefore, the guiding numerical information corresponds to the correlation information of the depth and the width of the cornea where the corneal implant 30 is inserted (inner-inserted).

Examples of the generated guiding index information are shown in Figs. FIG. 7 illustrates the right and left eyes of the operation subject. The numerical values in the uppermost row indicate parameter values for guiding numerical information sampled through processing such as scanning data analysis and linked numerical information generation as described above As shown in FIG.

7 and the like show seven sampled parameters of the guiding numerical information, and it goes without saying that these parameters can be generated to have more precise intervals as described above. 7, when the width of the cornea segment to be formed is 5.50 mm, the depth of the cornea where the segment is formed is 139 μm (right eye), and when the width of the cornea segment is 6.25 μm, Is 165um (right-hand side). These guiding index information corresponds to information unique to a specific operation subject, which is not the same for each operation subject.

Using the unique information of this guiding numerical information, accurate correlation of width and depth is generated. Therefore, when forming a slice with a laser device, information on the width alone can be used to adjust the correct corneal depth The corneal flap can be formed.

The main controller 140 of the present invention allows the surgeon to accurately confirm the guiding index information on the operation subject so that more accurate and precise operation can be performed and furthermore, ) Outputs the guiding index information to the screen display means (S240, 250).

The method of outputting the screen display means may include a method of outputting in the form of a sheet, a method of outputting in the form of a chart as shown in FIG. 7, a method of outputting through a predetermined intuitive interface environment, It is needless to say that various methods are available. In order to implement the ubiquitous environment according to the embodiment, the guiding index information may be transmitted in the form of a wireless data packet to the smartphone of the doctor.

Corneal implants inserted into the cornea after surgery can be improved to improve the near vision through the central cornea and to improve the middle distance vision and the far vision through the peripheral part formed by the cornea.

Therefore, if the section is formed at a too low depth, the pressing force at the central portion of the corneal implant becomes excessively low, resulting in an excessive protrusion shape, and the postoperative effect can be halved. If the section is formed at a depth deeper than that, And the surface of the corneal implant surface is increased, so that the post-operative effect described above may be lowered.

The depth of the section, that is, the thickness of the section to be pressed on the top of the corneal implant should be at least 150um, The total thickness of the cornea should be 30% or more. The structure of the present invention for realizing such a technical idea will be described later.

 On the other hand, it is more preferable to effectively implement the success of the operation and to accurately report the operation information to the doctor or the like so as to be more prudent in determining whether or not to perform the operation.

When the main control unit 140 outputs the guiding index information to the screen display means in order to implement it in the technical idea, the guiding index information corresponding to the following equation and the guiding index information not corresponding to the equation are different from each other (S230).

In the above equation, T is the corneal thickness information of the operation subject, and D is the depth information of the corneal flap in guiding index information.

As shown in the upper graph of FIG. 7, the guiding numerical information in which the depth of the slice is more than 150um or the depth of the slice is more than 30% of the corneal thickness of the subject is different from the guiding numerical information in a different way .

In the illustrated example, the right corneal flap depth is equal to or greater than 147 μm and the left corneal flap depth is equal to 144 μm according to Equation 1, since the right corneal thickness is 490 μm and the left eye is 480 μm.

In FIG. 7, examples in which shading and bold are used to develop in different ways are shown, but various guiding index information can be obtained using different colors, sizes, fonts, and the like, This is obvious.

That is, if the guiding index information that does not correspond to Equation (1) is controlled to be developed as the first method (S240), the guiding index information corresponding to Equation (1) (S250).

In addition, in order to perform more stable corneal implant surgery, and to maintain the distance from the retina and the maintenance of the improvement of visual acuity, it is desirable that the residual corneal thickness excluding the section is more than 300 μm or 60% of the corneal thickness information of the operation subject Do.

In order to implement the present invention from the viewpoint of corresponding to the above-described embodiment, when the main control unit 140 outputs the guiding index information to the screen display means, the guiding index information corresponding to the following equation So that the guiding index information is generated in a different manner (S230).

T is the corneal thickness information of the subject, D is the depth information of the corneal flap in the guiding index information, and "T - D" is the residual corneal thickness information.

That is, as shown in the lower chart of FIG. 7, the guiding numerical information in which the residual corneal thickness (TD) is 300um or more or the remaining corneal thickness is 60% or more of the corneal thickness of the operation subject and the non- Are configured to emerge in a differential manner.

In the illustrated example, the right corneal thickness is 490 μm and the left cornea is 480 μm. Therefore, the left corneal thickness should be greater than 294 μm and the left corneal thickness should be greater than 288 μm.

Therefore, as shown in the lower table of Fig. 7, the parameter range in which the remaining corneal thickness is 294 um (right eye) or more is distinguished into shading and bold. The differential approach to these values can be applied as in the example described above.

It is preferable that the guiding index information corresponding to the above-described equations (1) and (2) differs from the guiding index information which is not so different for the implementation of the more preferable embodiment.

That is, as illustrated in FIG. 8, the guiding index in which both of the preferable range for the section depth and the preferable range for the residual corneal thickness as shown in the bottom table of FIG. 7 are superimposed, .

In addition, the main control unit 140 of the present invention combines the guiding index information output by the differential scanning method with the input interface environment, and when the specific guiding index information is selected and input by the surgeon, It is preferable that the guiding index information is output to the laser device for forming the corneal flap (S260) so that more accurate corneal flap can be formed.

Hereinafter, another preferred embodiment of the present invention will be described with reference to FIG.

The present invention may further include a second input unit 160 in which personal information such as the age, ophthalmological condition, health condition, ophthalmologic history information, and the like of the operation subject is inputted (S300). When the personal information is inputted through the second input unit 160, the following formula is calculated using the above-described information on the eyesight of the operation subject and the cornea scanning data inputted at step S310 (S320).

In the above equation, T is the corneal thickness information of the operation subject, R is the corneal degeneration degree coefficient, Y is the current age information of the operation subject, y is the age degeneration coefficient, and K is the effective standard duration for the correction of the corneal implant.

Considering the depth (thickness) and residual corneal thickness of the corneal flap formed to perform effective and appropriate surgery and to maintain the corrected visual acuity as described above through FIG. 2, the total corneal thickness becomes 450um or more .

Therefore, if the total corneal thickness of the subject is not more than 450 μm, it may be desirable not to perform the operation. Therefore, the main control unit 140 of the present invention controls the alarm unit 170 using a medium such as visual, auditory, and tactile (vibration) to output alarm information about the surgical risk when the thickness of the entire cornea of the operation subject is less than 450um (S330).

From the viewpoint of correspondingness, if the total thickness of the cornea measured by the operation subject is 450um or more, alarm information indicating that the operation can be performed is generated and the information is output (S340).

Further, in order to perform a more stable operation, even if the measured total thickness of the cornea of the operation subject is 450um or more, if the degree of maintenance of the improved visual acuity may be insufficient considering the age of the operation subject, So that the operation subject or the doctor can accurately recognize the operation.

That is, considering the corneal degeneration degree coefficient R, the age degeneration coefficient y, the current age (Y) of the operation subject, and the effective standard duration K for the correction of the corneal implant, as shown in the right side of Equation (3) It is preferable to determine whether the entire thickness of the cornea of the operation subject is appropriate.

The corneal degradation coefficient (R) may vary depending on the corneal environment, reference conditions, and experimental conditions, but it is preferably set to 3 to 7 um / lyear, preferably to 5 um / lyear for more stable and safe surgical conditions. Further, in the case of the age degeneration coefficient (y), it is desirable to set the value to be a functionally valuable value for the age of the operation subject because the safety of the operation should be increased as the age of the current operation subject becomes older. Depending on the embodiment, the difference may be reflected by gender. In the description of the present invention, the age of the operation subject is 55 years. In this case, the age degeneration coefficient is set to 100, and the effective standard duration to be the reference is 10 years do.

[0035] When the above calculation is performed on the basis of the above-mentioned contents, the right hand side of the above Equation 3 is summarized as follows.

Therefore, if the total thickness of the cornea of the operation subject is not 477.5 μm, the probability that the operation lasts 10 years is low is low. In this case, the alarm information is controlled to be output as described above (S330).

When the alarm information on the operability or the like is generated and output through the above-described method, it is preferable to calculate the estimated value of the effective visual duration by the corneal implant surgery based on the following equation and output the calculated estimated value information (S350).

Estimate information about the Formula S are valid for eye duration in, T is the corneal thickness information of the operation target person, D _max is the maximum depth information of a corneal flap, D _min is the minimum depth information of a corneal flap, R is corneal degeneration coefficients, Y is the current age information of the operation subject, y is the age degeneration coefficient, and G is the minimum effective vision duration information.

As illustrated through the description of the present invention and the drawings, the guiding index range for slice formation of the subject is 6.00 mm to 6.50 mm (right side) in width, which is the width of the numerical range and the functionally corresponding depth It is preferable to perform the corneal implant surgery by forming a section in the range of 1 mm to 20 mm. The surgeon (doctor) can perform surgery by selecting specific values within the numerical range in consideration of other surgical factors, history information of the operation subject, and the like.

In the present invention, the residual corneal thickness information, the factor for the degradation described above and the minimum effective visual duration, the minimum residual corneal thickness, and the maximum effective corneal thickness are calculated based on the maximum (max) and minimum (min) The estimated value information on the effective visual duration is generated in accordance with Equation (4) by considering the set values (S350).

The results calculated using the parameters exemplified in accordance with the present invention are summarized as follows. In the following formula, the minimum effective visual acuity duration is set to 5 years, based on the residual corneal thickness of 300 μm.

As shown in the above table, in the case of the above-described example of the present invention, the estimated value of the effective visual acuity duration according to the depth of the section, that is, the position of insertion of the corneal implant is 8.636 years or more and 19.54 years or less. It is preferable that the information on the estimated duration duration thus generated is output to a screen display means or the like.

Information on the information generated by the preferred embodiment of the present invention, that is, the linked numeric information, the guiding index information, the effective visual duration, and the like, is stored in the storage unit 180 in association with the personal information of the operation subject It can be used as various DB in future.

While the present invention has been particularly shown and described with reference to exemplary embodiments thereof, it is to be understood that the invention is not to be limited to the details thereof and that various changes and modifications will be apparent to those skilled in the art. And various modifications and variations are possible within the scope of the appended claims.

It is to be understood that both the foregoing general description and the following detailed description are exemplary and explanatory and are intended to provide further explanation of the invention as claimed. It should be understood that various modifications may be made in the ordinary skill in the art.

It should be understood that the numerical values and numerical ranges exemplified in connection with the description of the embodiments of the present invention are not to be construed as meanings of specific numerical values that have been established to enhance convenience and ease of understanding of the technical idea of the present invention It is self-evident.

In addition, in the description of the present invention, the first and second expressions are terms of a tool concept used for relatively separating each component (element) between them, , Or it is to be interpreted that it is not a term used to physically distinguish each component from an absolute reference.

The optimized guiding index providing method of the corneal implant of the present invention can be implemented in the form of a program or an application mounted on and driven by a computer or a computer-equivalent apparatus. The computer- Lt; / RTI &gt; The computer-readable recording medium includes all kinds of recording devices (CD-ROM, RAM, ROM, floppy disk, magnetic disk, hard disk, magneto-optical disk, etc.) in which data that can be read by a computer is stored. It also includes a server for transmission.

100: Guiding Index Providing System
110: operation information input unit 120: cornea information generating unit
130: Numerical operation unit 140:
150: Screen display means 160: Second input unit
170: alarm unit 180: storage unit

Claims (2)

An information input step of inputting, from one or more measurement devices, scanning data on age information, vision information, corneal width and thickness of a subject to be operated;
Generating corneal information by parsing scanning data on the corneal width and thickness to generate linkage numerical information which is depth data of the cornea according to corneal width of the operation subject;
A numerical computation step of generating guiding index information, which is data on a correlation between a width and a depth of a corneal flap for insertion of the corneal implant, using the linked numerical information; And
And a main control step of outputting the guiding index information to the screen display means so that the guiding index information corresponding to all of the following equations and the guiding index information not corresponding to the guiding index information are displayed in a differential manner,

In the above equation, T is the corneal thickness information of the subject, D is the depth information of the corneal flap in the guiding index information, and (TD) is the remaining corneal thickness information.
Wherein the main control step comprises:
The estimated value of the effective visual acuity duration by the corneal implant is calculated and outputted by the following equation,

Estimate information about the Formula S are valid for eye duration in, T is the corneal thickness information of the operation target person, D _max is the maximum depth information of a corneal flap, D _min is the minimum depth information of a corneal flap, R is corneal degeneration coefficients, Y is the current age information of the operation subject, y is the age degeneration coefficient, and G is the minimum effective vision duration information.
And outputting alarm information on the user if the subject is a surgical subject corresponding to the formula below.

In the above equation, T is the corneal thickness information of the operation subject, R is the corneal degeneration degree coefficient, Y is the current age information of the operation subject, y is the age degeneration coefficient, and K is the effective standard duration for the correction of the corneal implant. 2. The method according to claim 1,
Combining the guiding index information with an input interface environment,
Further comprising an information output step of outputting the selected guiding index information to the laser device for forming a corneal flap when the specific guiding index information is selected and input by the surgeon through the interface environment, Delivery method.

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