KR20150107129A - Cosmetic composition containing glycerylhydroxypropyl alkyldimonium chloride - Google Patents

Abstract

The present invention relates to a cosmetic composition for external use containing glyceryl hydroxypropyl alkyldimonium chloride, which manufactures emulsifying formulation by using glyceryl hydroxypropyl alkyldimonium chloride which is a high hydrophilic cationic surfactant, and fatty alcohol by inducing a glyceryl hydroxypropyl group, thereby having excellent skin stability and emulsifying stability and having excellent moisturizing effect.

Description

Glyceryl hydroxypropyl alkyldimonium chloride (Cosmetic composition containing glycerylhydroxypropyl alkyldimonium chloride)

The present invention relates to a cosmetic composition containing glyceryl hydroxypropylalkyldimonium chloride. More specifically, the present invention relates to a cosmetic composition containing glyceryl hydroxypropyl alkyldimonium chloride, (O / W) emulsified cosmetic composition in which a higher alcohol and a cationic surfactant can stably contain an oil using glyceryl hydroxypropylalkyldimonium chloride as a surfactant.

When the normal keratinocyte layer is maintained at a moisture content of 10 to 30%, the skin is smooth and soft, and the body protection functions normally. However, when the moisture content of the keratinocyte layer is less than 10%, the skin becomes coarse and the protective function of the body is lost and aging phenomenon occurs. For example, in the case of dry skin, the aggregation force of keratinocyte is weakened, and a scaling phenomenon occurs in which keratinocytes are peeled off like scales from the skin surface. The reason why the skin is dried in this way is that the moisture content of keratinocyte layer is smaller than that of normal skin.

Besides, even the healthy skin, the harsh outside environment such as wind, cold weather. Sunlight, cleansing, and shaving can cause water shortage, which can make the skin condition worse. Therefore, it is very important to keep the moisture content of keratinocyte layer of skin properly. For this purpose, it supplies moisture to skin with cream and lotion to prevent dryness of skin and replenish useful ingredients for skin. In general, the emulsion formulation uses carbopol which is a polymer of acrylic acid as emulsifying stabilizer or thickener for emulsion stabilization. However, depending on the use of these polymers, the skin may feel sticky and dry after use.

As a prior art for improving this point, US Patent Publication No. US2001 0047039 discloses a method for producing a pesticidal composition such as Distearyldimonium chloride, PEG-3 Dioleoylamidoethylmonium methosulfate It has been proposed to use a cationic surfactant with an emulsifier having an HLB value of 1 to 6 in a ratio of 1: 1 to 1:25 to make a stable emulsifier without a polymer. However, when a large amount of such a cationic surfactant is used as an emulsifier, it has excellent moisturizing and feeling, but it has a disadvantage that it is likely to induce skin irritation and its use is limited.

Accordingly, the present inventors have found that, by using glyceryl hydroxypropylalkyldimonium chloride in which one lipophilic alkyl group of a cationic surfactant is substituted with a glyceryl hydroxypropyl group having high hydrophilicity and a fatty alcohol, It is possible to provide a cosmetic composition for skin use which can form an emulsifier having excellent feeling and moisturizing properties while having little irritation to the skin.

Accordingly, an object of the present invention is to provide a method of producing an emulsion formulation without a polymer by using glyceryl hydroxypropyl dimonium chloride and a fatty alcohol in which one lipophilic alkyl group is substituted with a glyceryl hydroxypropyl group having a high hydrophilicity, To provide a skin cosmetic composition which forms an emulsifier type excellent in usability and moisturizing feeling.

In order to achieve the above object, the present invention provides an oil / water (O / W) emulsified cosmetic composition containing a cationic surfactant glyceryl hydroxypropyl alkyl dimonium chloride and a fatty alcohol.

In the present invention, glyceryl hydroxypropylalkyldimonium chloride, which is a cationic surfactant, and fatty alcohols are contained in an amount of 0.5 to 15% by weight of the total composition to provide an emulsified composition having excellent emulsion stability and excellent spreading and moisturizing effect . At this time, glyceryl hydroxypropylalkyldimonium chloride, which is a cationic surfactant, and fatty alcohol may be contained in the cosmetic composition at a ratio of 1: 1.5 to 1: 5.

 Hereinafter, the present invention will be described in detail.

The cationic surfactant glyceryl hydroxypropyl alkyldimonium chloride used in the present invention has a structure represented by the following formula (1) and has a viscosity of 100 to 200 cps and a pH of 5 to 8 as a transparent liquid having an activity of 34%.

In the above formula, R is a C12-C20 alkyl group.

In a preferred embodiment of the present invention, the fatty alcohol may be a higher fatty alcohol having 16 to 22 carbon atoms.

In a preferred embodiment of the present invention, the mixing ratio of the cationic surfactant glyceryl hydroxypropylalkyldimonium chloride to the fatty alcohol is suitably from 0.5 to 15% by weight, more preferably from 3 to 10% by weight, Is good. If it is used in an amount of less than 0.5% by weight, the emulsion stability is lowered and the viscosity becomes too low. On the other hand, when it is used in excess of 15% by weight, the hardness becomes too high.

In a preferred embodiment of the present invention, the ratio of the cationic surfactant glyceryl hydroxypropylalkyldimonium chloride to the fatty alcohol is preferably 1: 1.5 to 1: 5, preferably 1: 3. When the ratio is less than 1: 1.5, the emulsion stability is lowered. When the ratio is more than 1: 5, the emulsion stability is excellent, but the hardness is excessively high.

In addition, the cosmetic composition of the present invention comprises an active ingredient for skin care.

In the present invention, the active ingredients for skin and beauty which may be contained in the cosmetic composition may include squalene, aloe vera, glycerin, amino acids, natural moisturizing factor (NMF), hyaluronic acid, 1,3- But are not limited to, polyethylene glycol, glucose, urea, sorbitol, lactic acid, glucuronic acid, galactose, propylene glycol, isopropyl myristate, inorganic ion components, triglyceride, mineral oil, silicone, ceramides, cholesterol, , Wax, and lecithin. Examples of whitening ingredients include arbutin, mulberry extract, licorice extract, raspberry extract, chrysanthemum extract, ethyl ascorbyl ether, ascorbyl glucoside, magnesium ascorbyl phosphate, ascorbic acid and its derivatives, , Tyrosinase, vitamins and derivatives thereof, and anti-wrinkle ingredients such as Asian ticoside, (AHA), adenosine, botox and derivatives thereof, and other known anti-inflammatory components, anti-inflammatory agents, anti-inflammatory agents, anti-inflammatory agents, But are not limited to, those known as active ingredients for skin cosmetics such as atopic ingredients and antibacterial ingredients.

In the present invention, at least one skin-active ingredient may be contained.

In the present invention, the cosmetic composition is applied as an external preparation for skin. Examples of the composition include a cream, a lotion, an essence, a gel or an ointment for a whole body or for a face, a hand or a foot.

The method for producing the cosmetic composition of the present invention can be generally produced by adding a fatty alcohol to an oil phase and an oil phase or an oil phase of glyceryl hydroxyalkyl dimethylonium chloride, which are required for an emulsifier type, and then emulsifying the emulsion.

In addition, the composition of the present invention can be used as components contained in conventional external skin application agents such as perfumes, coloring matters, bactericides, antioxidants, preservatives, and moisturizers.

INDUSTRIAL APPLICABILITY The cosmetic composition containing the glyceryl hydroxypropylalkyldimonium chloride of the present invention can be obtained by introducing a glyceryl hydroxypropyl group and using glyceryl hydroxypropylalkyldimonium chloride, which is a cationic surfactant having high hydrophilicity, and fatty alcohol, It is possible to provide a composition for external application for skin excellent in skin stability and emulsion stability and having excellent moisturizing effect.

Hereinafter, the present invention will be described in more detail with reference to the following examples. However, the scope of the present invention is not limited to the following examples.

Example 1  3 and Comparative Example  1 to 2

Glyceryl hydroxypropylalkyldimonium chloride, cetostearyl alcohol and other oil components were dissolved in an oil bath at 75 占 폚 and water components such as water, preservative and glycerin were dissolved at 75 占 폚 and mixed in an oil bath to prepare a conventional emulsifier Type manufacturing method. The blend ratio of each component was as shown in Table 1 below.

Category (% by weight) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 1 Glyceryl hydroxypropyl
Alkyldimonium chloride 0.2 4 2 - - Distearyl dimonium chloride - - - 4 - Cetostearyl alcohol 0.3 11 6 11 0.3 Squalene 3.0 3.0 3.0 3.0 3.0 Cyclopentasiloxane 5.0 5.0 5.0 5.0 5.0 Mineral oil 8.0 8.0 8.0 8.0 8.0 Concentrated glycerin 10.0 10.0 10.0 10.0 10.0 Dipropylene glycol 3.0 3.0 3.0 3.0 3.0 Carbopol - - - - 0.3 Triethanolamine - - - - 0.3 Fragrance / preservative Suitable amount Suitable amount Suitable amount Suitable amount Suitable amount Purified water to 100 to 100 to 100 to 100 to 100 [Note] -: no addition

Experimental Example  1: moisture Possession  evaluation

In order to evaluate the moisturizing power of the cream compositions of Examples 1 to 3 and Comparative Examples 1 and 2 of the present invention, a method of evaluating the water holding ability after applying a fixed amount to the skin was used.

The instrument used was Skicon 200 (high frequency: 3.5 MHz), a skin moisture analyzer for measuring the electrical conductivity of the skin. The Skicon 200 is a device for measuring the moisture content of the skin (corresponding to the keratinocyte layer) with a shallow thickness at a frequency of 3.5 MHz.

In the test method, a certain amount (2 mg / cm 2) of the compositions of Examples 1 to 3 and Comparative Examples 1 and 2 was applied to the inside of each arm of 20 subjects in a constant temperature and humidity room at 22 ° C and 45% And the short-term effect was evaluated by measuring the water increase rate (%) after 1 hour and 3 hours based on the water holding ability at 0 hour. The results obtained are shown in Table 2 below.

(%) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Early 100 100 100 100 100 After 1 hour 178 235 240 210 118 After 3 hours 175 233 241 205 120

As can be seen from the above Table 2, according to the present invention, the prescription using glyceryl hydroxypropylalkyldimonium chloride and fatty alcohols is more preferable than the emulsification prescription using a polymer such as carbopole, 1 hour and 3 hours after application And the growth rate of the holdings was much higher.

Experimental Example  2: Evaluation of moisture evaporation

Experiments were conducted to evaluate the moisture evaporation of the cream compositions prepared according to Examples 1 to 3 and Comparative Examples 1 and 2.

In the test method, a predetermined amount (2 mg / cm 2) was applied to the inside of each arm of 20 subjects in a constant temperature and humidity room at 22 ° C. and a relative humidity of 45%, and rubbed well. The results are shown in Table 3 below. ≪ tb > < TABLE >

(%) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 After 10 minutes
Moisture evaporation 36 30 22 34 50

As can be seen from the above Table 3, it can be seen that the prescription using glyceryl hydroxypropylalkyldimonium chloride and fatty alcohol shows much lower water evaporation than the emulsifying prescription using a polymer such as carbopole.

Experimental Example  3: Evaluation test for dry skin improvement effect

In order to evaluate the moisturizing effect of Examples 1 to 3 and Comparative Examples 1 and 2 by another method, dry skin improvement effect evaluation test was conducted.

The test method was as follows: Twenty adult men and women with dry backs were tested twice a day for a total of 3 months. Before the sample was used, the scales occurring on the skin of the subject's 4 cm x 4 cm area were selected as drying evaluation parameters, and the scale of the back of the hand was measured with a hand-held microscope (Handy Scope) To measure the scale area. Next, the cream compositions prepared according to Examples 1 to 3 and Comparative Examples 1 and 2 were applied to the backs of the hands of 20 subjects for 3 months, and then the scale area was measured and the results are shown in Table 4 . In this case, the numerical values in Table 4 represent the% of the scale area with respect to the total area.

(%) Example 1 Example 2 Example 3 Comparative Example 1 Comparative Example 2 Before use 15.0 14.8 15.2 15.1 15.0 after use 3.6 3.0 3.1 3.5 4.8

As shown in Table 4 above, the prescription using glyceryl hydroxypropylalkyldimonium chloride and fatty alcohols markedly reduced the scale area compared to the prescription using polymer such as carbopole.

Experimental Example  4: Skin irritation evaluation experiment

In order to evaluate skin irritation of the cosmetic compositions of Examples 1 to 3 and Comparative Examples 1 and 2, 50 adult male and female healthy persons were subjected to a patch test.

A predetermined amount (about 0.2 g) of each sample was applied to the pin chamber, and the sample was adhered to the skin of the subject for 24 hours by using a filter paper of an appropriate size to prevent loss of the sample. Then, the pin chamber was removed, The states of the stimuli and the stimuli responses were evaluated according to the criteria shown in Table 5 by the method of determining two experts, and the results were calculated by the following equation (1).

Score Reaction Criteria 0 -   No symptoms One + -   When there is only a slight erythema reaction 2 +   Clear erythema, edema, but no blisters 3 ++   If you have a clear erythema, edema, blisters 4 +++   When there is a logarithm

sample Judgment result (number of people) Skin irritation index ++ + + - - Example 1 0 0 One 49 0.02 Example 2 0 0 One 49 0.02 Example 3 0 0 2 49 0.04 Comparative Example 1 0 0 7 43 0.14 Comparative Example 2 0 0 4 46 0.08

As can be seen from the above Table 6, the cream prepared with glyceryl hydroxypropyldimonium chloride shows a stable skin irritation index as compared with the cream made with distearyl dimonium chloride, which is a general cationic surfactant And it was found.

From the above experiments, it was found that the cream prepared by using glyceryl hydroxypropylalkyldimonium chloride and fatty alcohol according to the present invention has better skin stability than the cream prepared by using general cationic surfactant, It was confirmed that the moisturizing effect was better than the cream. In addition, the cosmetic composition for external use for skin of the present invention has no problem about skin irritation and can be used as an effective and safe composition, such as essence, lotion, gel, ointment and the like.

As described above, the cosmetic composition containing the glyceryl hydroxypropyl alkyldimonium chloride of the present invention is a cosmetic composition comprising glyceryl hydroxypropyl group and glyceryl hydroxypropyl alkyldimonium chloride which is a cationic surfactant having high hydrophilicity It is an extremely useful invention in the cosmetics industry since it is possible to provide a composition for external application for skin which is excellent in skin stability and emulsion stability and also in moisturizing effect by producing an emulsified formulation using chlorides and fatty alcohols.

Claims (6)

A cosmetic composition comprising an oil-in-water (O / W) emulsified cosmetic composition comprising a skin cosmetic active ingredient and glyceryl hydroxypropyl alkyl dimonium chloride represented by the following formula (1) and a fatty alcohol:
[Chemical Formula 1]

In the above formula, R is a C12-C20 alkyl group.
The cosmetic composition according to claim 1, wherein the glyceryl hydroxypropylalkyldimonium chloride and the fatty alcohol are contained in an amount of 0.5 to 15.00% by weight based on the total composition.
The cosmetic composition according to claim 1, wherein the glyceryl hydroxypropyl alkyldimonium chloride and the fatty alcohol are mixed in a ratio of 1: 1.5 to 1: 5.
4. The cosmetic composition according to any one of claims 1 to 3, wherein the fatty alcohol is a higher fatty alcohol having 16 to 22 carbon atoms.
3. The composition of claim 1, wherein the active ingredient is at least one selected from the group consisting of squalene, aloe vera, glycerin, amino acids, Natural Moisturizing Factor (NMF), hyaluronic acid, 1,3-butylene glycol, polyethylene glycol, But are not limited to, sorbitol, lactic acid, glucuronic acid, galactose, propylene glycol, isopropyl myristate, triglyceride, mineral oil, silicone, ceramides, cholesterol, wax, lecithin, arbutin, Extracts, extracts of Chrysanthemum morifolium, extracts of Chrysanthemum morifolium, extracts of Echinacea, ascorbyl glucoside, magnesium ascorbyl phosphate, ascorbic acid, kojic acid, glutathione, tyrosinase, vitamins, asialicoside, ubidecarenone, (AHA), adenosine, and botox, which are known in the art. A cosmetic composition characterized in that at least one member selected from the group.
The cosmetic composition according to claim 1, wherein the formulation of the cosmetic composition is a cream, a lotion, an essence, a gel, or an ointment.