KR20150089021A - External preparation for skin - Google Patents

Abstract

The present invention relates to an external preparation for skin characterized by containing silver-bearing trivalent calcium phosphate, alum and zinc oxide. An object of the present invention is to provide a topical external preparation for skin which is capable of inhibiting discoloration at the time of adhering clothes with a skin external preparation containing a combination of silver-bearing trivalent calcium phosphate, which functions as a deodorant, and albumin,

Description

{EXTERNAL PREPARATION FOR SKIN}

The present invention relates to an external preparation for skin. More particularly, the present invention relates to an external preparation for skin, which contains silver-loaded tri-calcium phosphate powder, alum and zinc oxide, which is excellent in discoloration resistance when adhered to clothes and has excellent restricting effect and deodorizing effect will be. INDUSTRIAL APPLICABILITY The external preparation for skin of the present invention is intended for deodorization and is preferably used as an external preparation for skin, a deodorant cosmetic, a restricted cosmetic, and a deodorant cosmetic.

Patent Document 1 discloses the use of silver-supported calcium phosphate as a deodorant. Although there is a description of the effect that the limiting agent can be incorporated in the deodorant, there is no description of the limiting agent that can be specifically formulated, and no discoloration at the time of mixing the limiting agent has been described at all.

Patent Document 2 discloses that when the antimicrobial zeolite and zinc oxide powder are combined and dispersed in water, the base is discolored and clothes are liable to become dirty, and a composition for abatement is disclosed in which the discoloration is prevented with a specific dicarboxylic acid have. When antimicrobial zeolite is used as an external preparation for skin, discoloration tends to occur when it is combined with zinc oxide.

Patent Document 3 discloses a deodorant cosmetic composition excellent in stability of materials capable of preventing discoloration based on antibacterial zeolite when combined with antibacterial zeolite and alum or bovine alga that function as a limiting agent.

Patent Document 1: JP-A-08-126690 Patent Document 2: JP-A-2007-289452 Patent Document 3: JP-A-2004-307375

The inventors of the present invention have conducted studies on the use of supported calcium phosphate as a deodorant in consideration of the background of the above description, and as a result, it has been found that when silver-supporting trivalent calcium phosphate is combined with zinc oxide and antimicrobial zeolite and zinc oxide are combined , But it was found that discoloration occurs when the garment is attached with the alum, which is a limiting agent. The present inventors have found that the discoloration that occurs when silver trioxide calcium phosphate and silver alum are combined with silver oxide can inhibit the discoloration by adding zinc oxide, thereby completing the present invention.

It is an object of the present invention to provide a topical external preparation for skin which is capable of inhibiting discoloration at the time of adhering clothes by external preparation for skin combined with silver-supporting trivalent calcium phosphate, which functions as a deodorant,

That is, the present invention provides an external preparation for skin characterized by containing silver-bearing trivalent calcium phosphate, alum and zinc oxide.

Further, the present invention is characterized in that the content of the silver-loaded tri-calcium phosphate powder is 0.5 to 20 mass%, the content of alum is 1 to 20 mass%, and the content of zinc oxide is 0.05 to 10 mass% Which is the above-mentioned external preparation for skin.

In addition, the present invention provides the external preparation for skin, wherein the external preparation for skin is an aerosol spray type deodorant cosmetic preparation.

According to the present invention, it is possible to provide an external preparation for skin which is capable of inhibiting discoloration at the time of adhering clothes by zinc oxide, by a combination of silver-coated tri-calcium phosphate and alum, which is a limiting agent, with a skin external agent. Further, the external preparation for skin of the present invention has an advantage of less discoloration than the external preparation for skin using silver-supported antimicrobial zeolite.

"Silver-bearing phosphoric acid 3 calcium"

According to the present invention, it is possible to provide an external preparation for skin which is capable of inhibiting discoloration at the time of adhering clothes by zinc oxide, by a combination of silver-coated tri-calcium phosphate and alum, which is a limiting agent, with a skin external agent. Further, the external preparation for skin of the present invention has an advantage of less discoloration than the external preparation for skin using silver-supported antimicrobial zeolite. The amount of the supported calcium phosphate is preferably 0.1 to 20% by mass, more preferably 1 to 10% by mass with respect to the total amount of the external preparation for skin. When the blending amount is less than 0.1 mass%, the function as the deodorant may not be sufficiently exhibited. When the amount of the external preparation for skin of the present invention is more than 20% by mass, it may become too white when it is applied to the skin.

"alum"

The alum used in the present invention is an essential component that functions as a limiting agent. In the present invention, commercially available powder is used. The alum used in the present invention may be a small alum. As a commercial product, for example, Thai Ace S150, Thai Ace S100, Thai Ace K150, Thai Ace K20 (Taimei Chemical Industry Co., Ltd.) are preferably used.

The blending amount of alum is preferably from 1 to 20 mass%, more preferably from 2 to 10 mass%, based on the whole amount of the external preparation for skin. If the blending amount is less than 1% by mass, the function as a limiting agent may not be sufficiently exhibited. When the amount of the external preparation for skin of the present invention is more than 20% by mass, it may become too white when it is applied to the skin.

When alum is blended in an aerosol spray, it is preferable that the alum powder is a fine particle powder having an average particle size of 0.01 to 50 mu m. The average particle size is measured according to a conventional method such as the number average length by image analysis of a transmission electron microscope photograph.

"Zinc oxide"

In the external preparation for skin of the present invention, it has been found by the present inventors that discoloration occurs when the external preparation for skin attaches to clothing by combining silver-bearing trivalent calcium phosphate and alum, and found that the discoloration is inhibited by compounding zinc oxide. That is, in the present invention, zinc oxide is an essential component that functions as a discoloration inhibitor when adhering clothes. In the present invention, zinc oxide is blended as a powder. The preparation of zinc oxide and the particle size are not a problem.

In the composition for firing employing antibacterial zeolite, discoloration tends to occur particularly when zinc oxide powder is blended in an aqueous composition. However, the composition for firing employing silver-supported tri-calcium phosphate can be obtained by adding zinc oxide powder in an aqueous composition to an antimicrobial zeolite No discoloration occurs. In addition, suppressing discoloration at the time of attaching clothes, which is caused by a combination of zinc oxide silver-bearing trivalent calcium phosphate and albumin, exhibits remarkable effects unprecedented by those skilled in the art.

The blending amount of zinc oxide is preferably from 0.05 to 10% by mass, more preferably from 0.1 to 5% by mass, based on the whole amount of the external preparation for skin. If the blending amount is less than 0.05% by mass, the above discoloration inhibiting effect may not be sufficiently exhibited. On the other hand, if it exceeds 10% by mass, it may become too white when it is coated.

The external preparation for skin of the present invention may contain, in addition to the above-mentioned essential ingredients, other ingredients commonly used in external preparations for skin, for example, one or more of the following ingredients, if necessary, And can be produced by a conventional method. Preferable products are deodorant cosmetics and cosmetics, which are external preparations for dermal application.

Examples of oil fractions include camellia oil, macadamia nut oil, corn oil, olive oil, rapeseed oil, yolk oil, sesame oil, perilla oil, wheat germ oil, camellia oil, flaxseed oil, sunflower oil, cottonseed oil, Liquid fats such as peanut oil, tea oil, visa oil, rice bran oil, jojoba oil, embryo oil, triglycerin, glycerin trioctanoate, glycerin triisopalmitate; Solid retention of cacao paper, palm oil, hardened palm oil, palm oil, palm kernel oil, cotton seed oil, hardened oil, wood wax, hardened palm oil and the like;

Waxes such as beeswax, candelilla wax, carnauba wax and lanolin;

Hydrocarbons such as liquid paraffin, ozokerite, squalane, paraffin, ceresin, squalane, petrolatum, microcrystalline wax;

Octyldodecyl myristate, hexyl docyl palmitate, hexyl laurate, myristyl myristate, hexyldecyl dimethyloctanoate, cetyl lactate, myristyl lactate, isostearyl stearate, Diisostearic acid, isostearic acid, isostearic acid, 12-hydroxystearic acid cholesteryl, di-2-ethylhexyl acid ethylene glycol, dipentaerythritol fatty acid ester, dicaprylic acid neopentyl glycol, diisostearyl malate, Trimethylol propane, triisostearic acid trimethylol propane, tetra 2-ethylhexyl pentaerythritol, tri-2-ethylhexyl glycerin, triisostearic acid trimethylol propane, cetyl 2- Ethylhexanoate, 2-ethylhexyl palmitate, trimyristic glycerin, tri-2-heptylundecanoic acid glyceride, 2-heptylundecyl palmitate, diisopropyl adipate, N-lauroyl- Glue Octyldodecyl ester, 2-heptylundecyl adipate, di-2-ethylhexyl sebacate, 2-hexyldecyl myristate, 2-hexyldecyl palmitate, 2-hexyl adipate Decyl, diisopropyl sebacate, 2-ethylhexyl succinate and the like;

Higher fatty acids such as lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, oleic acid, 12-hydroxystearic acid, undecylene acid, lanolin fatty acid, isostearic acid, linolic acid, linolenic acid and eicosapentaenoic acid;

Butanol, lauryl alcohol, cetyl alcohol, stearyl alcohol, behenyl alcohol, myristyl alcohol, oleyl alcohol, cetostearyl alcohol, monostearyl glycerin ether (butyl alcohol) Straight chain or branched higher alcohols such as phytosterol, hexyldodecanol, isostearyl alcohol and octyldodecanol; And silicone oils such as dimethylpolysiloxane and methylphenylpolysiloxane.

Examples of the surfactant include N-acylsarcosinic acid such as fatty acid soap, alkyl ether sulfuric acid ester salt and sodium lauroyl sarcosinate, sodium N-myristoyl-N-methyltaurate, sodium palmitoylmethyltauride and the like Sulfosuccinic acid salts such as higher fatty acid amide sulfonic acid, monooroyl monoethanolamide sodium POE sulfosuccinate and sodium lauryl polypropylene glycol sulfosuccinate, alkylbenzenesulfonates, N-acylglutamates, higher fatty acid ester sulfate esters, Sulfuric acid such as lactic acid, POE alkyl ether carboxylic acid, POE alkyl aryl ether carboxylate, higher fatty acid ester sulfonate, secondary alcohol sulfate ester salt, higher fatty acid alkylolamide sulfuric acid ester salt, lauroyl monoethanolamide succinic acid Cationic surfactants such as sodium;

Dialkyldimethylammonium salts such as distearyldimethylammonium chloride; cationic surfactants such as alkylpyridinium salts such as cetylpyridinium chloride; and cationic surfactants such as benzalkonium chloride;

Imidazolin-type positive surfactants such as 2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt;

An amphoteric surfactant such as a betaine surfactant such as amide betaine or sulfobetaine;

Sorbitan fatty acid esters such as sorbitan monooleate, sorbitan monoisostearate, sorbitan monolaurate, sorbitan monopalmitate and sorbitan trioleate; Glycerin polyglycerin fatty acids such as monosaccharyl fatty acid glycerin, monostearic acid glycerin, sesquioleic acid glycerin and monostearic acid glycerin malate; propylene glycol fatty acid esters such as propylene glycol monostearate; A lipophilic nonionic surfactant such as a hydrogenated castor oil derivative, a glycerin alkyl ether, and a POE? Methyl polysiloxane copolymer; POE sorbitan fatty acid esters such as POE sorbitan monooleate and POE sorbitan monostearate; POE sorbit fatty acid esters such as POE sorbitol monolaurate, POE sorbit monooleate and POE sorbitan monostearate; POE glycerin fatty acid esters such as POE glycerin monooleate and POE glycerin distearate; POE fatty acid esters of POE distearate; POE alkyl ethers such as POE lauryl ether and POE cholestanol ester, POE alkyl phenyl ethers such as POE octyl phenyl ether and POE nonyl phenyl ether; POE · POP alkyl ethers such as POE · polyoxypropylene (hereinafter referred to as POP) monobutyl ether, POE · POP cetyl ether and POE · POP glycerin ether;

POE hardened castor oil derivatives such as POE hardened castor oil, POE hardened castor oil free monoisostearate and POE hardened castor oil free maleic acid;

Alkanolamides such as palm oil fatty acid diethanolamide and fatty acid isopropanolamide;

POE propylene glycol fatty acid esters, POE fatty acid amides, POE alkyl amines, sucrose fatty acid esters, alkyl ethoxy dimethyl amine oxides, and other hydrophilic nonionic surfactants.

Examples of the powder include mica, talc, kaolin, sericite, muscovite, gold mica, synthetic mica, purplish mica, biotite, rich mica, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride Aluminum oxide, barium sulfate, barium sulfate, barium silicate, calcium silicate, magnesium silicate, strontium silicate, aluminum oxide, barium sulfate, iron stalk, iron oxide iron, iron oxide black, cobalt oxide, (Nylon powder), a cellulose powder, an amorphous silica powder, and an amorphous silica powder, which are used in the present invention. Organopolysiloxane monostearate, aluminum powder, copper powder and the like.

Examples of the alcohols include lower alcohols such as ethanol, propanol, and isopropanol; and cholesterol, sitosterol, lanosterol, and the like.

Examples of the thickening agent include vegetable polymers such as gum arabic, tragacanth gum, galactan, carob gum, guar gum, carrageenan, pectin, agar, starch (corn, wheat, potato, rice);

Microbial polymers such as dextran and pullulan;

Starch polymers such as carboxymethyl starch and methylhydroxypropyl starch;

Cellulose-based polymers such as collagen, methylcellulose, ethylcellulose, hydroxyethylcellulose, sodium cellulose sulfate, hydroxypropylcellulose, carboxymethylcellulose, and crystalline cellulose;

Alginic acid-based polymers such as sodium alginate and propylene glycol alginate;

Vinyl-based polymers such as polyvinyl methyl ether and carboxyvinyl polymer;

POE-based polymers;

POE polyoxypropylene copolymer system polymer;

Acrylic polymers such as sodium polyacrylate and polyacrylic acid amide;

Bentonite, magnesium aluminum silicate, laponite, hectorite, silicic anhydride, and the like.

Examples of the chelating agent include hinokitiol, gallic acid, tannic acid, coffee acid, ethylenediamine tetraacetic acid, ethylene glycol diamine 4-acetic acid, diethylenetriamine 5-acetic acid, phytic acid, polyphosphoric acid, metaphosphoric acid, Maleic esters and the like.

Examples of the ultraviolet absorber include ultraviolet absorbers such as octyl paratomethoxy cinnamate, 4-tert-butyl-4'-methoxydibenzoylmethane and octocrylene.

Examples of the moisturizing agent include polyethylene glycol, propylene glycol, dipropylene glycol, 1,3-butylene glycol, glycerin, diglycerol, xylitol, maltitol, maltose, D-mannit, fructose, sodium hyaluronate, glucosamine, cyclodextrin And the like.

Examples of the active ingredient include vitamins such as retinol, retinol palmitate, pyridoxine hydrochloride, nicotinic acid amide, nicotinic acid dl-alpha tocopherol, magnesium ascorbic acid phosphate, vitamin D2, dl-alpha tocopherol, pantothenic acid and biotin;

Anti-inflammatory agents such as azulene and glycylic acid;

A whitening agent such as tranexamic acid and potassium 4-methoxysalicylate;

Astringents such as tannic acid;

L-menthol, and a refreshing agent such as camphor.

Examples of the preservative include paraffinic acid esters such as methylparaben, ethylparaben, butylparaben, sorbic acid, benzalkonium chloride, chlorohexidine chloride, trichlorocarbonylide, photosensitizer, phenoxyethanol, etc. .

As other compoundable components, neutralizing agents such as 2-amino-2-methyl-1-propanol, 2-amino-2-methyl-1,3-propanediol, potassium hydroxide, triethanolamine and sodium carbonate;

PH adjusting agents such as lactic acid, citric acid, glycolic acid, succinic acid, tartaric acid, malic acid, sodium hydrogencarbonate, and ammonium hydrogen carbonate;

Ascorbic acid, alpha tocopherol, carotinoid, and the like.

The product form of the external preparation for skin of the present invention is not particularly limited. For example, an aerosol spray type, a roll-on type, a powder type and a presto powder type, and a stick type. In the present invention, an aerosol spray form is particularly preferable. In the case of the aerosol spray form, the external preparation for skin of the present invention is prepared by filling the aerosol can with a conventional method such as a spraying agent such as liquefied gas or ethanol. In addition, although the alum is inferior in dispersibility in ethanol, the new finding that the alumina dispersibility in ethanol is improved by incorporating silver-bearing trivalent calcium phosphate was obtained by the present invention.

Example

Hereinafter, the present invention will be described more specifically by way of examples. The present invention is not limited to these embodiments. The compounding amount is% by mass with respect to the total amount unless otherwise specified.

Examples 1 to 9, Comparative Example 1

[Deodorant Spray]

The deodorant lotion of the powder lotion type was prepared in the compositions of the examples and comparative examples shown in Table 1, and then charged into a 50 mL glass tube. The redispersibility and sedimentation rate of the powder were evaluated by the following methods. In addition, the deodorant lotion was evaluated by the following method by discoloring when the aerosol container was filled with the undiluted solution (powder lotion): LPG gas = about 2: 8 and adhered to the clothes.

≪ Redispersibility of powder >

After filling in a 50 mL glass tube, the powder was allowed to stand for 1 hour, and the glass tube was shaken and stirred to confirm the redispersibility.

<Judgment>

○: Redisperse by shaking within 5 times.

X: No redispersing even if shaking more than 20 times.

<Settling velocity of powder>

After filling in a 50 mL glass tube, the mixture was allowed to stand evenly, and then the sedimentation rate of the powder was visually observed.

<Judgment>

○: No separation of the upper layer was observed for more than 20 seconds.

X: The separation of the upper layer was confirmed within 10 seconds.

<How to confirm discoloration>

The deodorant spray was applied for 3 seconds under the armpits and spent eight hours in daily life in white clothing. Later, when the clothes were left under room light for 2 hours, the discoloration was visually observed.

<Judgment>

?: No discoloration is recognized.

X: Discoloration is recognized.

Comparative Example
1 Example 1 Example 2 Example 3 Example 4 Example 5 Example 6 Example 7 Example 8 Example 9 Comparative Example 2 Example 10 Example 11 ethanol To
100% To
100% To
100% To
100% To
100% To
100% To
100% To
100% To
100% To
100% To
100% To
100% To
100% water - - - - - - - - - - - 2 5 alum 5 5 5 5 5 5 10 10 20 5 5 5 5 (* 1) &lt; / RTI &gt; 2 2 2 5 5 5 2 5 2 10  - 2 2 Zinc oxide (* 2) - 0.25 0.5 0.5 - - 0.5 0.5 0.5 0.5 0.5 0.5 0.5 Zinc oxide (* 3) - - - - 0.5 - - - - - - - - Zinc oxide (* 4) - - - - - 0.5 - - - - - - Redistribution of powder

Settling velocity of powder

Discoloration when attached to clothing

* 1: Apa Cider C:

* 2: Fine zinc oxide: Sakai Chemical Industry Co., Ltd.

* 3: Zinc nitrate AZO-BS: Fujimoto Chemical Products Co., Ltd.

* 4: Japanese pharmacy zinc oxide (for liquid): Sakai Chemical Industry Co., Ltd.

From the results shown in Table 1, it was found that discoloration occurred when adhered to clothing when a combination of calcium triphosphate and albumin was combined (Comparative Example 1 and Comparative Example 2). From Examples 1 to 11, however, it was found that the discoloration can be prevented by adding zinc oxide.

Further, it was found that the alum in ethanol had poor redispersion properties and there was a problem (Comparative Example 2), but red dispersion was well accomplished by mixing silver-loaded trivalent calcium phosphate and this problem could be solved. In addition, it was found that the sedimentation rate of the powder was accelerated by mixing water at 5 mass% or more (Example 11). Considering the filling process of the aerosol container at the time of production, it is preferable that the powder lotion is excellent in redispersibility and slow in sedimentation rate. Therefore, in the present invention, it is more preferable that water does not contain 5% by mass or more of the total amount of the powdered lotion as the external preparation for skin.

Prescription Example 1 Deodorant Spray (mass%)

(Undiluted solution)

alum  5

Apache C 10

Zinc oxide (zincation)  2

Anhydrous silicic acid 10

Calcium stearate 0.5

Talc 10

Corn starch 12.5

Decamethylcyclopentasiloxane 15

Methylphenylpolysiloxane 12

2-ethylhexanoate  8

PPG-20 decyltetradeceth-10  3

Dimethicone (6 cs) 12

The above components are mixed to prepare a deodorant stock solution, which is filled in a spray can, and then LPG is sealed so that the stock solution: LPG is 5:95.

Prescription Example 2 Deodorant Spray (mass%)

(Undiluted solution)

alum  5

Apache C  2

Zinc oxide (zincation)  One

Anhydrous silicic acid  One

ethanol 71.5

2-ethylhexanoate 10

Dimethicone (6 cs)  8

PEG-9 dimethicone  One

L-menthol 0.5

The above components are mixed to prepare a deodorant stock solution, which is filled in a spray can, and then LPG is sealed so that the stock solution: LPG is 10:90.

Prescription Example 3 Deodorant Lotion (mass%)

alum  2

Apache C  2

Zinc oxide (zincation)  One

Anhydrous silicic acid  One

ethanol 86.5

glycerin  3

1,3-butylene glycol  3

L-menthol  One

Spices 0.5

The ingredients are mixed and filled into a bottle or mist container to obtain a lotion-like composition.

Prescription Example 4 Deodorant stick (mass%)

alum  5

Apache C  5

Zinc oxide (zincation)  One

Anhydrous silicic acid  8

Solid paraffin wax  7

Stearyl alcohol 10

Liquid paraffin 10

Decamethylcyclopentasiloxane 43.5

Methylphenylpolysiloxane  8

PEG-9 dimethicone  2

Glutathione 0.5

The above components are heated and mixed to fill the stick container and cooled to room temperature to obtain a stick container composition.

Prescription Example 5 Deodorant Powder (mass%)

alum  3

Apache C  2

Zinc oxide (zincation) 0.5

Talc 90

Anhydrous silicic acid 4.5

The components are mixed in a mixer to obtain a powdery composition.

[Industrial Availability]

According to the present invention, it is possible to provide a topical external preparation for skin which is capable of inhibiting discoloration at the time of adhering a garment by an external preparation for skin combined with silver-bearing trivalent calcium phosphate, which functions as a deodorant, INDUSTRIAL APPLICABILITY The external preparation for skin of the present invention is excellent as a limiting effect and a deodorizing effect, and is very useful as a limiting cosmetic and deodorizing cosmetic.

Claims (3)

Characterized in that it contains calcium triphosphate, alum and zinc oxide. The cosmetic composition according to claim 1, wherein the content of the silver-coated tri-calcium phosphate powder is 0.5 to 20% by mass, the alumina content is 1 to 20% by mass, and the zinc oxide content is 0.05 to 10% A skin external preparation characterized by. The external preparation for skin according to claim 1 or 2, wherein the external preparation for skin is an aerosol spray type deodorant cosmetic preparation.