KR20150088466A - Method for preparing surfactant-free oral gagle - Google Patents

Abstract

The present invention relates to a method for manufacturing a surfactant-free oral gargle and, more specifically, to a method for manufacturing a surfactant-free oral gargle, which emulsifies menthol which is a fragrance ingredient and a refreshing agent, citric acid which is a pH adjusting agent, an oil ingredient of ethanol which is a solvent, cetylpyridium chloride which is an anticavity agent, sodium nitrate which is a basic pH adjusting agent, xylitol, sodium saccharin, and stevioside which are sweeteners, ethanol which is a solvent, and RO water which is a diluent using sodium benzoate. According to the present invention, the ingredients can be effectively emulsified without floatation of the oil ingredient in the gargle by not using a surfactant. The gargle is very effective in preventing cavity and gingivitis, removing plaque and bad breath, and inhibiting bad breath and is also easy to use.

Description

[0001] The present invention relates to a method for preparing a surfactant-free oral gagle,

The present invention relates to a method for producing a mouthwash for a mouthwash without a surfactant, and more particularly, to a method for producing a mouthwash for a mouthwash for a mouthwash using a surfactant, wherein the surfactant is emulsified by using sodium benzoate, The present invention relates to a method for manufacturing a mouthwash for oral use.

In general, the environment in the oral cavity has been left in harmful conditions to various mouths such as bad breath, plaque formation, tooth decay, gum disease, pigmentation due to the inability to completely remove the residual residue due to various food consumption.

So-called toothbrushes and toothpastes have been used to remove residues of foods and plaque from the mouth in order to solve the problem of hygiene in the oral cavity since the 1950's. Such toothpastes are usually made of a surfactant and a polishing agent, It is well known that toothbrushes, which are physical cleaning tools, are used to remove residual food residues in the oral cavity, in particular, teeth.

Since then, toothpastes containing various active ingredients such as fluorine toothpaste and dental cleansing agent have been developed and various advances have been made in terms of hygiene of teeth.

In addition, oral toothpaste containing ethanol, water, antibacterial components and various active ingredients beneficial to various mouths has been developed and marketed, which has helped to clean the oral hygiene easily.

The present invention relates to an oral hygiene composition for oral hygiene, which can dissolve and gel into water or saliva by oral water or saliva, Is about 15 seconds, and it is generally found that the tablets are unsuitable for being used in water. In addition, there is a problem that it is not suitable for a person having extremely few teeth when chewing a pill into his mouth, or for a person who dislikes a foreign body feeling that occurs when chewing.

On the other hand, interest in health and social well-being is increasing, and a new concept of oral cleansing agent is needed in pursuit of well-being. In recent years, in accordance with natural and environmentally friendly consumption trends, the use of synthetic materials or chemical raw materials among the active ingredients in oral products has not been used or the use of oral cleaning agents has been expanded on the basis of the pharmacological properties of natural products.

In addition, there is an oral product which does not use a surfactant, alcohol, pigment and synthetic antimicrobial agent. However, since the oil component is not completely emulsified in the oral product, there is suspended matter in the product and it is difficult to feel refreshing feeling such as freshness and coolness after use .

Korean Patent No. 10-0822647 Korean Patent No. 10-1156169

In order to solve the problems of the prior art as described above, the present invention provides a method for producing a mouthwash for a mouthwash without a surfactant, which causes various diseases such as halitosis, stomatitis and dermatitis by emulsifying an oil component using sodium benzoate The purpose.

Another object of the present invention is to provide a method for manufacturing a mouthwash for a mouthwash without a surfactant, which can emulsify the oil component in the goggles without floating, without using a surfactant.

Another object of the present invention is to provide a method for manufacturing a mouthwash for oral cavity, which is excellent in the effect of preventing tooth decay and gingivitis, eliminating plaque, and removing bad breath, and is easy to use.

In order to achieve the above-mentioned object, the present invention provides a method for producing a flavor enhancer comprising the steps of: adding a flavoring agent, menthol as a refreshing agent, citric acid as an acidic pH controlling agent and cetylpyridinium chloride as a tooth decaying agent, sodium citrate as a basic pH adjusting agent, The present invention provides a method for manufacturing a mouthwash for a mouthwash without a surfactant, which comprises emulsifying xylitol, sodium saccharin and stevioside, ethanol as a solvent, and RO water as a diluent with sodium benzoate.

Specifically, the present invention provides

Mixing the oil component of (S1) flavoring agent, menthol as a refreshing agent, citric acid as an acidic pH controlling agent, and ethanol as a solvent, and pre-emulsifying the mixture for 100 to 150 minutes;

(S2) Cetylpyridinium chloride as a tooth decay agent, sodium citrate as a basic pH controlling agent, xylitol as a sweetening agent, sodium saccharin and stevioside, ethanol as a solvent, and sodium benzoate as a diluent are mixed and stirred for 50 to 70 minutes Thereby preparing a concentrated liquid;

(S3) adding a high concentration liquid of the above (S2) to the RO number as a diluent and uniformly mixing for 50 to 70 minutes; And

(S4) slowly adding the precursor emulsion of (S1) to the mixed solution of (S3) for 200 to 280 minutes and mixing;

.

The oral goggles may contain 0.1 to 30 parts by weight of a flavoring agent, 0.5 to 8 parts by weight of a refreshing agent, 5 to 15 parts by weight of an acidic pH adjusting agent, 1 to 10 parts by weight of a tooth decay agent, 10 to 20 parts by weight of a controlling agent, 1 to 40 parts by weight of a sweetener, 0.1 to 10 parts by weight of sodium benzoate and 1 to 5 parts by weight of a solvent.

In addition, the preparation of the oral goggles may further include foaming agents such as polyoxyethylene hardened castor oil, coloring agents, and the like.

The present invention also provides a detergent-free oral goggle prepared by the above method.

The oral goggles according to the present invention can effectively emulsify the oil components in the gag without float without using a surfactant and solve the problems of various diseases such as mouth odor, stomatitis and dermatitis caused by the use of surfactant In addition, it has an effect of preventing tooth decay and gingivitis, eliminating plaque, eliminating bad breath, suppressing the generation of bad breath, and being easy to use.

Hereinafter, the present invention will be described in detail.

The oral goggles of the present invention are characterized by being prepared by emulsifying an oil component and an aqueous component to be added to oral goggles using sodium benzoate without containing a surfactant.

That is, the present invention provides a composition for oral goggles which is capable of effectively emulsifying oil components using sodium benzoate without using a surfactant added for emulsifying oil components in conventional oral care products And dissolution can be facilitated.

The oral goggles of the present invention can be manufactured as follows.

In the present invention, the flavoring agent, the flavoring agent, the pH adjusting agent, the solvent, the dentifrice prevention agent, the sweetener, the diluent, etc. contained in the mouth gag of the present invention should be used within the range of the content of the present invention, so that efficient emulsification of the oil component with sodium benzoate And it is possible to easily mix and dissolve the emulsified component and the remaining components. Therefore, even though each ingredient contained in the oral goggles of the present invention is a component commonly used in oral products, if the ingredient is included only in the same amount as the present invention, the present invention is not limited to the use of sodium benzoate It is obvious that the constitution of the present invention is a remarkably advanced technique in comparison with the technologies for the conventional oral product.

First, the oil components added to the oral goggles, that is, the flavoring agent, the sweetening agent, the acidic pH adjusting agent and the solvent are mixed and emulsified beforehand.

The flavoring agent is preferably used as the flavoring agent, and the flavoring agent is preferably included in an amount of 0.1 to 30 parts by weight, more preferably 20 to 25 parts by weight, based on 100 parts by weight of the mouth gargle .

The refreshing agent is preferably used in an amount of 0.5 to 8 parts by weight, more preferably 1 to 5 parts by weight, based on 100 parts by weight of the total amount of mouthwash for oral use .

It is preferable to use citric acid as the acidic pH adjusting agent. The citric acid acts to pre-emulsify the oil components by mixing them. The acidic pH adjusting agent is preferably included in an amount of 5 to 15 parts by weight, more preferably 10 to 13 parts by weight, based on 100 parts by weight of the mouth gargle.

The solvent is preferably ethanol, and it is preferable that the solvent is contained in an amount corresponding to one half of the amount added to 100 parts by weight of the mouthwash for oral use, which is 1 to 5 parts by weight.

In the case of the above-mentioned solvent, the entire amount may be added during the emulsification process as an oil component. However, in order to alleviate the sudden reaction of the RO water and the solvent in the subsequent process, the amount of the solvent is divided into half, .

The oil component is mixed and emulsified for 100 to 150 minutes. At this time, citric acid acts as an emulsifier, and the oil component can be uniformly mixed and emulsified. If the time for the pre-emulsification is less than 100 minutes, the pre-emulsification can be performed stably, and if it exceeds 150 minutes, the stable pre-emulsification can not be performed.

Then, the remaining components other than the above-mentioned oil component, that is, the antifouling agent, the basic pH adjuster, the sweetener, the solvent and the diluent, and the sodium benzoate are mixed. The above components may be mixed in the diluent as they are, but in this case, since the components may not be mixed in the exact amount and proportion due to the dust generated during the injection of the components, the components other than the oil component may be separately mixed and then mixed with the diluent It is good practice to divide into steps.

The type of the dental caries prevention agent is not limited as long as it is a component used for oral care purposes such as prevention of tooth decay and prevention of gingivitis used in ordinary oral compositions. However, in order to achieve the object of the present invention, cetyl pyridinium chloride Is more preferable.

Preferably, the dental caries prevention agent is included in an amount of 1 to 10 parts by weight, more preferably 4 to 6 parts by weight, based on 100 parts by weight of the mouth gargle.

The basic pH adjusting agent is preferably sodium citrate. The sodium citrate is preferably contained in an amount of 10 to 20 parts by weight, more preferably 16 to 20 parts by weight, based on 100 parts by weight of the mouthwash for oral use.

The sweetener is not particularly limited as long as it is a sweetener component used in a conventional oral composition. However, in order to attain the object of the present invention, a combination of three components of xylitol, sodium saccharin and stevioside is used It is good.

The sweetener is preferably contained in an amount of 1 to 40 parts by weight based on 100 parts by weight of the total amount of the mouthwash for oral use, and more preferably 20 to 30 parts by weight of xylitol, 0.1 to 2 parts by weight of sodium saccharin and 1 to 10 parts by weight of stevioside More preferable.

As described in the previous emulsification step, it is preferable to add an amount of half of the total amount of the solvent used in the oral goggle to alleviate the sudden reaction of the RO water and ethanol as a solvent.

The RO number is preferably used as the diluent, and the RO number is preferably added in such an amount that the components to be mixed can be uniformly mixed. That is, it may be added in an appropriate amount to the amount required for mixing the components in the total amount used for manufacturing the oral goggles.

The remaining components except for the oil component are mixed with sodium benzoate and stirred for 50 to 70 minutes to prepare a high concentration liquid.

The sodium benzoate is used as a preservative in a conventional oral composition. In the present invention, the sodium benzoate is used as an emulsifying agent to emulsify the oil component used in oral goggles and the remaining components.

The sodium benzoate is preferably contained in an amount of 0.1 to 10 parts by weight, more preferably 3 to 6 parts by weight, based on 100 parts by weight of the total amount of the oral goggles. If the content is less than 0.1 part by weight, the oil component contained in the mouth gag and the remaining components may not be emulsified well, resulting in floating or layer separation. If the content is more than 10 parts by weight, the effect may be insignificant .

When the stirring time is within the above range, the taste and flavor of the mouth gag can be optimally maintained.

In addition, the components other than the above-mentioned oil components are preferably prepared from a high concentration liquid concentrated to 6 to 10 times as much as the final produced gag oil.

In the preparation of the high concentration liquid, a solubilizing agent, a coloring agent and the like may be further added as necessary.

The solubilizing agent and complexing agent may be used without limitation as long as it is a common ingredient used in an oral composition. Particularly, polyoxyethylene hardened castor oil is preferably used as a solubilizing agent.

Subsequently, the above-prepared high concentration liquid is added to RO water as a diluent and uniformly mixed for 50 to 70 minutes. The pre-emulsified oil components are slowly added to the mixed solution for 200 to 280 minutes and mixed.

The high concentration liquid is preferably added to the RO number so as to have a volume ratio of 1:55 to 70, preferably 1:60.

When the pre-emulsified oil components are mixed into the mixed solution containing the high concentration liquid, the sodium benzoate dissolved in the mixture acts as an emulsifier to uniformly disperse and dissolve the oil components added to the mixed solution.

In this case, when the addition of the pre-emulsified oil components proceeds quickly, uniform mixing with the mixed solution may not be performed. Therefore, it is preferable to add slowly for 200 to 280 minutes, preferably 240 minutes as described above.

The oral goggle of the present invention produced as described above is completely emulsified and dissolved so that there is no suspension of oil components in the gag without addition of a surfactant, so that there is no foreign substance or the like when used, and the odor induction caused by the use of surfactant, It is possible to prevent the occurrence of various diseases such as stomatitis, dermatitis, etc., and it is possible to see effects such as prevention of tooth decay and gingivitis, removal of plaque, and prevention of bad breath by simple use.

Hereinafter, the present invention will be described in more detail with reference to examples. These embodiments are for purposes of illustration only and are not intended to limit the scope of protection of the present invention.

Example 1

0.25 g of flavor 113496 as a flavoring agent, 0.04 g of L-menthol as a refreshing agent, 0.13 g of citric acid as an acidic pH regulator, and 2 g of ethanol as a solvent were mixed and stirred for about 120 minutes before being emulsified.

Next, 0.05 g of cetylpyridinium chloride, which is a tooth decaying agent, 0.2 g of sodium citrate as a basic pH regulator, 0.3 g of xylitol as a sweetener, 0.008 g of sodium saccharin and 0.08 g of stevioside, 2 g of ethanol as a solvent, And a small amount of RO water were added, and the mixture was stirred for about 60 minutes.

The 3-ton tank was filled with RO water, and the high concentration liquid was added thereto so as to have a volume ratio of 1:60. After the mixture was homogeneously mixed for about 60 minutes, the pre-emulsified oil components were slowly added to the mixture for about 240 minutes Mouth gag was prepared.

Examples 2 to 4

The same procedure as in Example 1 was carried out except that the components and compositions of the following Table 1 were used.

The oral goggles prepared in Examples 1 to 4 were uniformly mixed with all ingredients without any foreign matter or suspended matter in the gaggle solution, and it was confirmed that even if stored for 1 month or longer, the liquid was stably maintained without separation of layers or formation of floating matters I could.

Comparative Example 1

A general gag ("'" gagagle) containing a surfactant was used.

EXPERIMENTAL EXAMPLE 1 Inhibitory effect on plaque formation

The occurrence of plaque was evaluated by Plaque Index (Tureaky Quigley and Hein) method.

30 persons aged between 21 and 35 were selected as experimental subjects and divided into 6 groups of 6 persons each having a uniform grade. To achieve the same conditions, all subjects in the 6 groups were provided with a standard toothpaste and a toothbrush for one week. At this time, toothpaste and toothbrush were used three times a day, and oral hygiene products except toothpaste and toothbrush were discontinued. Using a standard toothpaste and a toothbrush three times a day, the goggles of Examples 1 to 4 were used five times a day for at least 30 seconds so as to be gagged for four weeks. After 4 weeks, the plaque attached to the teeth of all the subjects was colored with a dental disclosing solution. The plaque of the individual teeth and the plaque of the lingual surface were rated according to the criteria shown in Table 2, 3.

By rating 0 point If there is no bacterial membrane on the tooth 1 point If there is a bacterial membrane in the gingival margin when punctured 2 points If there is a bacterial membrane on the gingival streak with a clear line 3 points If there is a bacterial membrane on the tooth side of the tooth side 1/3 or less 4 points More than 1/3 to 2/3 of the cervical area side If there is a bacterial membrane on the tooth surface 5 points If there is a bacterial membrane on the cervical side 2/3

As shown in Table 3, there was no statistical significance between the experimental groups of Examples 1 to 4 and Comparative Example 1 at the beginning (p < 0.05). However, in the experimental group of Comparative Example 1 after 4 weeks, the plaque was reduced on the front teeth and the interproximal surfaces, and in the experimental groups of Examples 1 to 4, the total index of plaque was decreased significantly in all teeth, <0.05), indicating that the plaque index decreased statistically significantly in molars. From these results, it can be seen that the gags of Examples 1 to 4 according to the present invention are more effective in suppressing the generation of plaque.

Experimental Example 2. Removal of bad breath

A total of 30 men and women who did not have dental caries were selected and cross-over test was conducted for the beverage. Commercial garlic powder was dispersed in water and allowed to stand for 24 hours and diluted so that the measured value of halimeter was 700 ppb or more. The diluted solution was used as a source of bad breath. After 30 minutes of gagging with 15 mL of garlic dilution, the degree of halitosis was measured with a halimeter for 1 minute, and then the gargle was gagged for 30 seconds using the goggles of Examples 1 to 4 and Comparative Example 1, respectively. After 30, 5, and 30 minutes after the gaggle, the degree of halitosis was measured with a Halley meter to confirm whether or not the halitosis suppression was continued, and the results are shown in Table 4 below.

division After 30 seconds of gagging Gaggle in 5 minutes Gaggle after 30 minutes Example 1 74.5% 73.2% 67.0% Example 2 86.2% 83.5% 75.3% Example 3 78.3% 74.6% 70.4% Example 4 88.6% 84.0% 74.2% Comparative Example 1 55.7% 45.5% 5.9%

As shown in Table 4, the goggles of Examples 1 to 4 were persistent in halitosis suppression, whereas the goggles of Comparative Example 1 showed slight persistence of halitosis suppression up to 5 minutes after the gaggle, .

Experimental Example 3. Sensory Evaluation

30 adult men and women were selected as experimental subjects and divided into 5 groups of 6 persons. All subjects were instructed to use the goggles of Examples 1 to 4 and Comparative Example 1, and then the oral cooling sensation, And the results are shown in Table 5 below.

division Example 1 Example 2 Example 3 Example 4 Comparative Example 1 Oral cooling sensation 4.4 ± 0.5 4.5 ± 0.4 4.4 ± 0.2 4.5 ± 0.3 4.0 ± 0.2 Scented 4.5 ± 0.4 4.4 ± 0.2 4.4 ± 0.3 4.4 ± 0.2 3.5 ± 0.3 Overall likelihood 4.5 ± 0.3 4.5 ± 0.5 4.4 ± 0.5 4.5 ± 0.3 3.8 ± 0.4

As shown in Table 5, the mouthwashes of Examples 1 to 4 prepared according to the present invention were superior to oral gauze of Comparative Example 1 in oral cooling feeling and flavor, and overall taste was also excellent.

Although the present invention has been described in terms of the preferred embodiments mentioned above, it is possible to make various modifications and variations without departing from the spirit and scope of the invention. It is also to be understood that the appended claims are intended to cover such modifications and changes as fall within the scope of the invention.

Claims (7)

Cetylpyridinium chloride, which is a preventive agent for tooth decay, sodium citrate, which is a basic pH regulator, xylitol as a sweetening agent, sodium saccharin and stevioside, solvent as a sweetening agent, citric acid as a pH adjusting agent for acid, Wherein the ethanol and the diluent RO water are emulsified with sodium benzoate to prepare a mouthwash for a mouthwash without a surfactant. The method according to claim 1,
Mixing the oil component of (S1) flavoring agent, menthol as a refreshing agent, citric acid as an acidic pH controlling agent, and ethanol as a solvent, and pre-emulsifying the mixture for 100 to 150 minutes;
(S2) Cetylpyridinium chloride as a tooth decay agent, sodium citrate as a basic pH controlling agent, xylitol as a sweetening agent, sodium saccharin and stevioside, ethanol as a solvent, and sodium benzoate as a diluent are mixed and stirred for 50 to 70 minutes Thereby preparing a concentrated liquid;
(S3) adding the high concentration liquid of the above (S2) to the number of RO as the diluent and uniformly mixing for 50 to 70 minutes; And
(S4) slowly adding the precursor emulsion of (S1) to the mixed solution of (S3) for 200 to 280 minutes and mixing;
Wherein the surfactant-free oral gauze is added to the oral gauze. 3. The method of claim 2,
The oral goggles may contain 0.1 to 30 parts by weight of a flavoring agent, 0.5 to 8 parts by weight of a refreshing agent, 5 to 15 parts by weight of an acidic pH adjusting agent, 1 to 10 parts by weight of a tooth decay agent, Wherein the surfactant is prepared by using 10 to 20 parts by weight of a surfactant, 1 to 40 parts by weight of a sweetener, 0.1 to 10 parts by weight of sodium benzoate, and 1 to 5 parts by weight of a solvent. 3. The method of claim 2,
Wherein the high concentrated liquid is added to the RO water in a volume ratio of 1:55 to 70 in step (S3). 3. The method of claim 2,
Wherein the step (S2) further comprises adding a polyoxyethylene hardened castor oil as a foaming agent to the non-surfactant-added oral gauze. 3. The method of claim 2,
Wherein the step (S2) further includes a coloring agent. 6. A detergent-free oral goggle made by the method of any one of claims 1 to 6.