KR20150067298A - 티로신 수용체 키나아제 btk 억제제로서의 치환된 n-(3-(피리미딘-4-일)페닐)아크릴아미드 유사체 - Google Patents

티로신 수용체 키나아제 btk 억제제로서의 치환된 n-(3-(피리미딘-4-일)페닐)아크릴아미드 유사체 Download PDF

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KR20150067298A
KR20150067298A KR1020157011754A KR20157011754A KR20150067298A KR 20150067298 A KR20150067298 A KR 20150067298A KR 1020157011754 A KR1020157011754 A KR 1020157011754A KR 20157011754 A KR20157011754 A KR 20157011754A KR 20150067298 A KR20150067298 A KR 20150067298A
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hydrogen
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halogen
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하리프라사드 반카얄라파티
벤카타스와미 소르나
스티븐 엘. 워너
데이비드 제이 베얼스
수닐 샤르마
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유니버시티 오브 유타 리서치 파운데이션
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    • C07F9/65583—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system each of the hetero rings containing nitrogen as ring hetero atom
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A61K31/6615—Compounds having two or more esterified phosphorus acid groups, e.g. inositol triphosphate, phytic acid

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  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
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KR1020157011754A 2012-10-04 2013-10-04 티로신 수용체 키나아제 btk 억제제로서의 치환된 n-(3-(피리미딘-4-일)페닐)아크릴아미드 유사체 Withdrawn KR20150067298A (ko)

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Application Number Priority Date Filing Date Title
US201261709534P 2012-10-04 2012-10-04
US61/709,534 2012-10-04
PCT/US2013/063555 WO2014055934A2 (en) 2012-10-04 2013-10-04 Substituted n-(3-(pyrimidin-4-yl)phenyl)acrylamide analogs as tyrosine receptor kinase btk inhibitors

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KR20150067298A true KR20150067298A (ko) 2015-06-17

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US (1) US9296703B2 (enExample)
EP (1) EP2903971B1 (enExample)
JP (1) JP6313772B2 (enExample)
KR (1) KR20150067298A (enExample)
CN (1) CN104822663B (enExample)
CA (1) CA2887465A1 (enExample)
WO (1) WO2014055934A2 (enExample)

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CN104822663B (zh) 2012-10-04 2017-03-08 犹他大学研究基金会 作为酪氨酸受体激酶btk抑制剂的取代的n‑(3‑(嘧啶‑4‑基)苯基)丙烯酰胺类似物
JP6401169B2 (ja) 2012-10-04 2018-10-03 ユニヴァーシティー オブ ユタ リサーチ ファウンデーション チロシン受容体キナーゼｂｔｋ阻害剤としての置換ｎ−（３−（ピリミジン−４−イル）フェニル）アクリルアミド類似体
CN109153680B (zh) 2016-07-07 2021-04-23 株式会社大熊制药 4-氨基吡唑并[3,4-d]嘧啶基氮杂双环衍生物及含其的药物组合物
WO2019013562A1 (ko) 2017-07-12 2019-01-17 주식회사 대웅제약 신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
KR102384924B1 (ko) 2017-07-12 2022-04-08 주식회사 대웅제약 신규한 1h-피라졸로피리딘 유도체 및 이를 포함하는 약학 조성물
KR102613433B1 (ko) * 2017-10-11 2023-12-13 주식회사 대웅제약 신규한 페닐피리딘 유도체 및 이를 포함하는 약학 조성물
WO2020045941A1 (ko) 2018-08-27 2020-03-05 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
KR102328682B1 (ko) 2018-08-27 2021-11-18 주식회사 대웅제약 신규한 헤테로사이클릭아민 유도체 및 이를 포함하는 약학 조성물
KR20210142154A (ko) 2019-03-21 2021-11-24 옹쎄오 암 치료를 위한 키나제 억제제와 조합된 dbait 분자
CN114761006A (zh) 2019-11-08 2022-07-15 Inserm(法国国家健康医学研究院) 对激酶抑制剂产生耐药性的癌症的治疗方法
WO2021148581A1 (en) 2020-01-22 2021-07-29 Onxeo Novel dbait molecule and its use
JOP20220199A1 (ar) 2020-02-26 2023-01-30 Daewoong Pharmaceutical Co Ltd طريقة لتحضير مشتقات أمين حلقي غير متجانس

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CN104822663B (zh) 2012-10-04 2017-03-08 犹他大学研究基金会 作为酪氨酸受体激酶btk抑制剂的取代的n‑(3‑(嘧啶‑4‑基)苯基)丙烯酰胺类似物

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JP6313772B2 (ja) 2018-04-18
EP2903971B1 (en) 2019-06-12
WO2014055934A2 (en) 2014-04-10
WO2014055934A3 (en) 2014-06-26
CA2887465A1 (en) 2014-04-10
EP2903971A4 (en) 2016-05-25
CN104822663A (zh) 2015-08-05
US20150368208A1 (en) 2015-12-24
US9296703B2 (en) 2016-03-29
EP2903971A2 (en) 2015-08-12
HK1213244A1 (en) 2016-06-30
JP2015535851A (ja) 2015-12-17
CN104822663B (zh) 2017-03-08

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