KR20150048801A - Preservative mixtures, and polymer solutions stabilized therewith - Google Patents

Abstract

An aqueous polymer solution stabilized with a preservative mixture of 0.01 to 0.2% by weight of ethylhexyl glycerol, 0.001 to 0.01% by weight of 2-methylisothiazolinone, and 0.05 to 0.5% by weight of phenoxyethanol. The stabilized polymer solution is suitable for cosmetic preparations such as skin care and hair care compositions, decorative cosmetics and cosmetic cleansing products.

Description

[0001] PRESERVATIVE MIXTURES, AND POLYMER SOLUTIONS STABILIZED THEREWITH [0002]

The present invention relates to a specific bactericidal preservative mixture and an aqueous polymer solution stabilized with a preservative mixture or stabilized by mixing with said disinfecting effective individual components and to its use in cosmetic preparations such as skin care and hair care compositions and hair styling products do.

Microbial growth such as bacteria and viruses as well as fungi and yeast in polymer solutions, especially aqueous polymer solutions, must be avoided in many respects. The microorganisms in the aqueous polymer solution cause the accumulation of unhealthy fungi and constitute a high hygiene hazard, especially when the polymer solution is added to the cosmetic as a binder, thickener or film former.

It is known to stabilize an aqueous polymer solution with a bactericide as a preservative to combat the accumulation of fungi in question. These are added to the aqueous polymer solution as an additive. However, some known preservatives have been found to be carcinogenic and not suitable for use in cosmetic preparations. A further disadvantage of these additives is that product stability is not recorded. This, therefore, causes very frequent bleaching, turbidity, phase separation, unpleasant odor changes and insufficient microbial utility in polymer solutions mixed therewith.

It is therefore an object of the present invention to avoid the accumulation of undesirable fungi in aqueous polymer solutions while maintaining good product stability. It is a further object of the present invention to develop a technique that allows the manufacture of cosmetics without worrying about its ingredients.

The above object is achieved by the present invention.

The present invention relates to an aqueous polymer solution stabilized with a mixture of a preservative and a booster (hereinafter "preservative mixture"):

- 0.01 to 0.2% by weight of ethylhexyl glycerol

- 0.001 to 0.01% by weight of 2-methylisothiazolinone

- 0.05 to 0.5% by weight of phenoxyethanol.

The present invention also provides a polymer obtained from a solution / solution present in a stabilized aqueous polymer solution.

The invention also relates to the use of an aqueous polymer solution in cosmetic preparations such as skin care and hair care compositions, hair styling products, decorative makeup and cosmetic cleansing products, such as shampoos, shower gels and liquid soaps.

The present invention also relates to a preservative mixture for stabilizing an aqueous polymer solution.

Dependent claims relate to preferred embodiments of the aqueous polymer solution of the present invention, its polymers and uses thereof.

The amount of preservative mixture component is for 100% aqueous polymer solution.

The aqueous polymer solutions of the present invention comprise ethylhexyl glycerol, 2-methylisothiazolinone and phenoxyethanol components as bactericidal active ingredients, with balanced low dosages. These specific preservative mixtures exhibit unexpected effects on the microbial stabilization of the aqueous polymer solutions of the present invention within a low concentration range. Synergistically intensifying effectiveness is against various fungal and bacterial mixtures, such as gram-positive and gram-negative bacteria, yeast and fungi. From this point of view, the product stability of the aqueous polymer solution of the present invention is maintained. These results were unpredictable in that the mixture was present in the polymer solution, especially at very low concentrations.

According to the present invention, an aqueous polymer solution comprises, for stabilization, a preservative mixture of ethylhexyl glycerol, 2-methylisothiazolinone and phenoxyethanol components in the following amounts:

Based on 100% by weight aqueous polymer solution,

0.01 to 0.2% by weight of ethylhexyl glycerol,

0.001 to 0.01% by weight of 2-methylisothiazolinone and

0.05 to 0.5% by weight of phenoxyethanol.

Preferred aqueous polymer solutions include:

0.04 to 0.15% by weight of ethylhexyl glycerol,

0.003 to 0.008% by weight of 2-methylisothiazolinone and

0.1 to 0.5% by weight of phenoxyethanol.

Very particularly preferred aqueous polymer solutions include:

0.04 0.004% by weight ethylhexyl glycerol,

0.0038 占 .0004% by weight of 2-methylisothiazolinone,

0.5 ± 0.05 wt% of phenoxyethanol.

The present invention similarly describes a preservative mixture used for stabilization of an aqueous polymer solution.

The preservative mixture (mixture A) of the present invention has the following ingredients as bactericidal active ingredients:

On the basis of 100% by weight of the mixture,

62.5% by weight of phenoxyethanol

25.0% by weight of ethylhexyl glycerol and

1.25% by weight of 2-methylisothiazolinone,

Remaining water.

A further preservative mixture (mixture B) of the present invention has the following ingredients:

On the basis of 100% by weight of the mixture,

86.20% by weight of phenoxyethanol

6.9% by weight of ethylhexyl glycerol and

0.69% by weight of 2-methylisothiazolinone

Remaining water.

The aqueous polymer solution of the present invention is microbiologically stabilized by a specific preservative mixture. For achieving the claimed concentration range in the aqueous polymer solution, the mixture A is used in an amount of 0.08 to 0.8% by weight. Mixture A is used in an amount of from 0.2 to 0.6% by weight for obtaining a desired aqueous polymer solution. Mixture B is used in an amount of from 0.4 to 0.6% by weight for obtaining a very particularly preferred aqueous polymer solution.

The term "polymer" includes linear, water soluble, branched or water insoluble linear and branched polymers. The term "water-insoluble branched polymer" includes so-called popcorn polymers, which are referred to as "proliferative polymers" or PVPP as in the case of polyvinylpyrrolidone. In the context of the present invention, "branched", "branched", "bridged", "crosslinked" are used interchangeably to mean a polymer having one or more branch points.

"Polymer" also includes a copolymer, a graft homopolymer, or a graft copolymer, which in each case can be linear or soluble-crosslinked, in particular water-soluble crosslinked or insoluble-crosslinked, especially water-insoluble crosslinked polymers.

"Polymer" can be present in any form, for example a di- or multi-block polymer, and can be in star form, brush form, hyperbranched form or dendrimer.

The polymer according to the invention comprises at least one monomer a), optionally at least one monomer b) and optionally at least one crosslinking monomer c), that is to say they are obtained by means of a specific monomer polymerization and may also contain residual monomers .

The monomer a) is selected from:

N-vinylpyrrolidone, N-vinylpyrrolidone, N-vinylpiperidone, N-vinylcaprolactam, 3-methyl-, 4-methyl- or 5-methyl- Vinyl acetate and N-vinyl lactam, preferably a mixture of N-vinyl pyrrolidone, vinyl acetate and N-vinyl lactam and / or vinyl imidazole and / or vinyl imidazole and / Or acrylates and methacrylates comprising the acid and its monomer mixture with quaternized vinylimidazole, diamines and diisocyanates for forming polyurethanes with or without terminal EO / PO fatty alcohols, N-vinyl formates N-vinyl amides such as amides and their N-vinyl amines obtainable by hydrolysis after polymerization, N-vinyl-N-methylacetamide.

N-vinyl- or allyl-substituted heterocyclic compounds, preferably N-vinylpyridines or N-allylpyridines, N-vinylimidazoles, C1-4-alkyl, especially methyl or phenyl, in the 2-, 4- or 5- Vinylimidazole, 1-vinyl-2-methyl (ethyl) vinylimidazole, and quaternized derivatives thereof, such as 3-methyl-1-vinylimidazolium chloride, 3 -Methyl-1-vinylimidazolium methyl (ethyl) sulfate, N-C1- to C24-alkyl-substituted diallylamine or its quaternized derivative, an amine such as diallylammonium chloride or diallyldimethylammonium chloride and diamine .

Here, the polymer of the present invention preferably comprises at least one N-vinyl lactam monomer.

Polymers of the present invention are homopolymers or copolymers of two or more monomers a), such as copolymers of N-vinylpyrrolidone and N-vinylimidazole, N-vinylpyrrolidone and N- Amides, copolymers of N-vinylpyrrolidone and N-vinylcaprolactam, copolymers of N-vinylpyrrolidone, N-vinylcaprolactam and N-vinylimidazole or copolymers of N-vinylpyrrolidone And copolymers of N-vinylimidazole and quaternized N-vinylimidazole.

Preferred monomers a) are vinyllactams such as N-vinylpyrrolidone, 3-methyl-N-vinyl-pyrrolidone, 4-methyl-N-vinylpyrrolidone, N-vinylpiperidone and N-vinylcaprolactam, vinyl acetate, and vinyl amides obtainable by hydrolysis after polymerization, vinyl amides such as vinyl formamide, and vinyl amines obtainable by hydrolysis after polymerization, N-vinyl Imidazole, 1-vinyl-3-methylimidazolium chloride, 1-vinyl-3-methylimidazolium sulfate, and derivatives thereof.

Further preferred monomers a) are acrylates and methacrylates and their acids and diamines.

Very particularly preferred monomers a) are N-vinylpyrrolidone, N-vinylcaprolactam, vinyl acetate, vinylformamide, and also vinylamine obtainable by hydrolysis after polymerization, and N-vinylimidazole.

Suitable monomers b) are all monomers specified as "monomers b)" on WO020 / 72640 A1 page 6 line 8 to page 8 line 17, the entirety of which is incorporated herein by reference in its entirety.

Preferred monomers b) are selected from the group consisting of acrylate, acrylic acid, alkyl acrylate, alkyl acrylate, methacrylate, methacrylic acid, alkyl methacrylate, alkyl methacrylic acid, maleic acid, maleic anhydride, isopropyl methacrylamide, , Vinyl esters of aliphatic C2-C18-carboxylic acids such as methacrylamide, 2-hydroxyethyl-acrylamide and 2-hydroxyethyl methacrylamide, also vinyl acetate, as well as vinyl alcohols obtainable by hydrolysis after polymerization, Vinyl propionate, vinyl butyrate, vinyl stearate, vinyl neodecanoate VEOVA 9 and VEOVA 10, also dimethylaminoethyl (meth) acrylate and dimethylaminoethyl (meth) acrylamide and its quaternized derivatives, and also di Allyl dimethyl ammonium chloride and diisocyanate, and also styrene and styrene derivatives.

Very particularly preferred monomers b) are selected from the group consisting of methacrylamide, vinyl acetate, vinyl alcohols obtainable by hydrolysis after polymerization, vinyl propionate, vinyl neodecanoate VEOVA 9 and VEOVA 10, also dimethylaminoethyl (meth) acrylate Or dimethylaminoethyl (meth) acrylamide and quaternized derivatives thereof, and also diallyldimethylammonium chloride.

Polymers comprising monomers b), as well as copolymers, may comprise one or more monomers b). However, usually no more than 5 different monomers b) are present in one polymer.

Preferred polymers further comprise copolymers comprising one or more monomers a) and / or one or more monomers b).

Suitable cross-linking monomers c) (cross-linking agents) are, for example, cross-linked monomers c) described in WO 2009/024457 page 7 line 1 to page 9, line 2, the entirety of which is incorporated herein by reference.

Very particularly preferred monomers c) are selected from the group consisting of pentaerythritol triallyl ether, methylene bisacrylamide, N, N'-divinylethylene urea, divinylbenzene, ethylenebis-N-vinylpyrrolidone, Triallylamine and acrylic acid esters of vinylpyrrolidone, 4-vinyl-N-vinylpyrrolidone, 5-vinyl-N-vinylpyrrolidone, allyl (meth) acrylate, glycol, butanediol, trimethylolpropane or glycerol , Acrylic acid esters of glycols, butanediol, trimethylol propane or glycerol, also reacted with ethylene oxide and / or epichlorohydrin.

The weight fraction based on the total weight of the polymer of the present invention is generally 20% by weight or more, preferably 30% by weight, particularly preferably 50% by weight or more, particularly preferably 60% by weight or more, more preferably 60% Is 100% by weight or less, for example 100% homopolymer of monomer a).

The weight fraction based on the total weight of the polymer of the present invention is generally 80% by weight or less, preferably 70% by weight or less, particularly preferably 50% by weight or less, particularly preferably 40% by weight or less, Is not more than 5% by weight, for example, does not exist in the polymer as a whole.

When the polymer is a water-soluble crosslinked polymer, the amount by weight of the polymer of the monomer c) based on the total weight% by weight is usually 0.001 to 20% by weight, preferably 0.01 to 10% by weight, particularly preferably 0.05 to 5% To 1% by weight.

When the polymer is a water-insoluble crosslinked polymer, for example, in the case of a popcorn polymer, the amount by weight of the polymer of the monomer c) based on the total weight is usually 0.001 to 10% by weight, preferably 0.01 to 5% by weight, 0.1 to 3% by weight, particularly 0.5 to 2% by weight.

When a crosslinkable monomer c) is used, the total quantitative fraction of monomer a) and any monomer b) is reduced to the amount of crosslinking monomer c) used.

The monomers a), b) and c) used in the polymerization can be independently of one another or a mixture of two or more monomers a), b) and / or c), wherein the monomers a), b) and The combined quantitative fractions of c) provide the quantitative fractions specified in each case for the polymer reference monomers a), b) or c).

The total amount of monomer a) (s) plus monomer b) (s) plus monomer c) (s) is always 100% by weight.

The vinyl lactam polymer may be selected from the group consisting of N-vinylpyrrolidone (VP) or its 3, 4- or 5-position methyl-substituted derivatives, N-vinylpiperidone or N-vinylcaprolactam Containing homopolymer or copolymer. Preferred are N-vinylpyrrolidone, N-vinylcaprolactam or mixtures thereof. N-vinylpyrrolidone is particularly preferred.

Preferred vinyl lactam polymers are vinyl pyrrolidone polymers such as polyvinyl pyrrolidone, vinyl pyrrolidone copolymers and vinyl pyrrolidone popcorn polymers.

The preferred polyvinylpyrrolidone is a polymer having a K value of 1 to 150, preferably K10 to K120, such as K12, K15, K17, K25, K30, K60, K85, K90, K95, K100, K115 or K120. Particularly preferred PVP homopolymers have a K value of from 12 to 95 and particularly preferably from 30 to 90, in particular K30, K60, K85 and K90.

Preferred vinylpyrrolidone copolymers include N-vinylcaprolactam (VCap), vinyl acetate (VAc), N-vinylimidazole (VI), quaternized N-vinylimidazole and / or derivatives thereof and / It is a linear, non-crosslinkable copolymer with a mixture.

Particularly preferred copolymers are N-vinylpyrrolidone (VP) copolymers with vinyl acetate having a VP / VAc weight ratio of 20:80 to 80:20, such as 30:70, 50:50, 60:40, 70:30, and the K value is from 10 to 90, preferably from 15 to 80 and especially from 20 to 60. Very particularly preferred copolymers are N-vinylpyrrolidone copolymers with vinyl acetate, with a K value of from 22 to 40 and a weight ratio of VP to VAc of from 50:50 to 70:30.

Similarly preferred are copolymers of VP and VCap with K values between 10 and 100, preferably between 12 and 80 and especially between 20 and 75, with a monomer VP to VAc weight ratio of 20:80 to 80:20, for example 70: 30 to 30:70, preferably 70:30 to 30:70, particularly preferably 60:40 to 40:60, for example 50:50.

The K value of the vinylpyrrolidone copolymer and polyvinylpyrrolidone (see Fikentscher K value; see, for example, Buhler, "Polyvinylpyrrolone-Excipient for Pharmaceuticals", Springer, 2005, pages 40-41) It is a measure of viscosity. As a result, this is a direct measure of the molar mass. For example, when the molar mass changes as a result of the oxidation process, it induces an increase in the molar mass (induces an increase in the K value) or induces a decrease in the molar mass (induces a decrease in the K value) Induce change. As the molar mass changes, the solution viscosity of the solution with the specified solids content also changes accordingly.

Preferred aqueous polymer solutions are polyvinylpyrrolidone solutions, polyvinylpyrrolidone / polyvinylacetate solutions and polyurethane solutions.

The aqueous polymer solution is prepared, for example, by mixing in a preservative mixture of the present invention or by conventional means by direct mixing in the individual components of three specific preservative / booster.

The stabilizing polymer of the present invention is prepared from an aqueous solution by conventional methods, for example, spray drying, drying on contact surfaces, drying such as drying by vacuum means.

According to the present invention, an aqueous polymer solution stabilized with a preservative mixture and its polymer are used, for example, in cosmetic preparations such as binders, thickeners or film formers. Examples of such cosmetic preparations are skin care and hair care compositions. Skin care compositions include, for example, creams, gels, gel creams, waxes, wax gels, gel waxes and lotions. Hair care compositions include, for example, creams, gels, gel creams, waxes, wax gels, gel waxes, styling and conditioning foams, as well as sprays (pump sprays and aerosol sprays) and lotions. In this respect, cosmetic cleansing products including shower gels and bath gels are also mentioned.

The stabilized aqueous polymer solutions and polymers thereof according to the invention are likewise applicable to decorative cosmetic products. This includes, for example, makeup, lipstick, concealer and mascara.

Cosmetic preparations are usually in the form of gels, foams, sprays or emulsions, and may contain a plurality of additional cosmetic additives. Depending on the use of the formulation of the invention, further additives may also be mixed; These include, but are not limited to, emulsifiers, pearl waxes, stabilizers, salts, thickeners, viscosity modifiers, inorganic and organic UV light protection filters, self tanning agents, pigments, antioxidants, perfume ingredients, biogenic active ingredients, Is selected from the group formed with benzoic acid or wetting agents such as citric acid, glycerol, ethanol, propylene glycol, anti-dandruff, swelling agents and perfumes. Preferred biogenetic active ingredients herein are especially tocopherol, tocopherol acetate, tocopherol palmitate, deoxyribonucleic acid, coenzyme Q10, ascorbic acid, retinol and retinyl derivatives, bisanolyl, allantoin, , Ceramides, essential oils, hyaluronic acid, creatine, protein hydrolysates, plant extracts, peptides and vitamin complexes.

A further aspect of the present invention is the use of an aqueous polymer solution stabilized in accordance with the present invention as a conditioning agent in a hair care composition or a polymer thereof. The stabilized aqueous polymer solution or the polymer thereof according to the present invention may be used in hair shampoos, hair care compositions, hair lotions, hair treatments, hair gels, hair mousse, conditioners, hair tonics, and hair styling products, Mousse, hair gel, hair mousse, hair fixative composition (such as spray and lotion), and hair wax. Use in hair shampoos requires the use of additional surfactants and also adjuvants and additives. The addition of further conventional additives depends on the particular product.

Depending on their bactericidal properties and their use at very low concentrations, the preservative mixture of the present invention is particularly suitable for aqueous polymer solution stabilization. The product stability of the stabilized polymer solution is maintained for a long time, the appearance and sensory characteristics are unchanged, there is no discoloration or turbidity, phase separation of the solution. The polymer solution of the present invention and the polymer thereof exhibit excellent microbial stability and can be mixed without worrying about cosmetic and hair care compositions and also hair styling products.

The invention is illustrated by reference to the following examples.

Example

Example 1

(Protectol PE), ethylhexyl glycerol (Sensiva SC 50), and 2-methylisothiazolinone (Microcare MT) were mixed with an aqueous polyvinylpyrrolidone (PVP) solution (Luviskol K 85L, 20% strength aqueous solution) Of the preservative mixture. The concentration of constituents in the PVP solution is 0.001% 2-methylisothiazolinone, 0.1% ethylhexyl glycerol and 0.5% phenoxyethanol.

Ph.D. using stabilized PVP solution. The bacterial loading test according to Eur., 7th Edition was carried out after 28 days to determine the free (total) amount of test strain for test strains of Pseudomonas aeruginosa (ATCC 9027), Staphylococcus aureus (ATCC 6638), Candida albicans (ATCC 10231) and Aspergillus brasiliensis freedom.

In addition, the more stringent "KoKo test" (KoKo test SM 021) easily satisfied subsequent repetitions.

The stability test of the PVP solution indicates that the PVP solution is still clean and colorless after 12 weeks of storage. No change in odor was recorded.

Comparative Example 1

An aqueous polyvinylpyrrolidone (PVP) solution (Luviskol K 85L, 20% strength aqueous solution) was mixed with a preservative mixture of ethylhexyl glycerol and phenoxyethanol (Euxyl PE 9010). The concentration of constituents in the PVP solution is 0.05% ethylhexyl glycerol and 0.45% phenoxyethanol.

Ph. Eur., 7th Edition did not pass the germicidal loading test. After 28 days there was a clustering of Aspergillus brasiliensis (ATCC 16404) despite the freedom of test strains of Pseudomonas aeruginosa (ATCC 9027), Staphylococcus aureus (ATCC 6638), and Candida albicans (ATCC 10231) . The KoKo test was rejected and severe fungal growth occurred after only one inoculation cycle.

The stability test of immediate-use hair gel showed yellowing of the product after 3 months.

Example 2

Aqueous polyurethane (PUR) solution (Luvigel Star, alkoxylated polyurethane modified with fatty alcohol) was dissolved in ethylhexyl glycerol (Sensiva SC 50), 2-methylisothiazolinone (Microcare MT) and phenoxyethanol Protektol PE). The concentration of constituents in the polyurethane solution was 0.2% ethylhexyl glycerol, 0.01% 2-methylisothiazolinone and 0.5% phenoxyethanol.

Using the stabilized PUR solution, Ph. The bacterial loading test according to Eur., 7th Edition was carried out after 28 days to determine the free (untreated) strains of test strains of Pseudomonas aeruginosa ATCC 9027, Staphylococcus aureus ATCC 6638, Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404 freedom.

In addition, the more stringent "KoKo test" (KoKo test SM 021) easily satisfied subsequent repetitions.

Comparative Example 2

Aqueous polyurethane (PUR) solution (Luvigel Star, alkoxylated polyurethane modified with fatty alcohol) was mixed with a preservative mixture of ethylhexyl glycerol and phenoxyethanol (Euxyl PE9010). The concentration of the constituents in the polyurethane solution is 0.125% ethylhexyl glycerol and 1.125% phenoxyethanol. At very high feedstock concentrations of the preservative, Ph. The bacterial loading test according to Eur., 7th Edition was acceptable for Pseudomonas aeruginosa (ATCC 9027), Staphylococcus aureus (ATCC 6638), and Candida albicans (ATCC 10231) 28 days later, but for Aspergillus brasiliensis (ATCC 16404) I did not. Ph. Eur. Standards A and B according to 7th edition were not satisfied.

The KoKo test results also show that the solution has significant clustering after only one inoculation cycle.

In addition, these polymer solutions with a preservative mixture of 2 in comparison show turbidity / phase separation, discoloration and strong odor related instability after storage at various temperatures (6 ° C, RT, 40 ° C) and also emulsion and gel viscosity The results of this study are as follows.

Example 3

(Protectol PE), ethylhexyl glycerol (Sensiva SC 50), and 2-methylisothiazolinone (Microcare MT) were mixed with an aqueous polyvinylpyrrolidone (PVP) solution (Luviskol K 90L, 20% strength aqueous solution) Of the preservative mixture. The concentration of constituents in the PVP solution is 0.004% 2-methylisothiazolinone, 0.04% ethylhexyl glycerol and 0.5% phenoxyethanol.

Ph.D. using stabilized PVP solution. The bacterial loading test according to Eur., 7th Edition was carried out after 28 days to determine the free (untreated) strains of test strains of Pseudomonas aeruginosa ATCC 9027, Staphylococcus aureus ATCC 6638, Candida albicans ATCC 10231 and Aspergillus brasiliensis ATCC 16404 freedom.

In addition, the more stringent "KoKo test" (KoKo test SM 021) readily satisfied subsequent 6 doses (in each case, free from fungi after 6 doses).

Comparative Example 3

An aqueous polyvinylpyrrolidone (PVP) solution (Luviskol K 90L, 20% strength aqueous solution) was mixed with a preservative mixture of ethylhexyl glycerol and phenoxyethanol (Euxyl PE 9010). The concentration of constituents in the PVP solution is 0.05% ethylhexyl glycerol and 0.45% phenoxyethanol.

Ph. Eur., 7th Edition did not pass the germicidal loading test. After 28 days, freedom from only limited fungi was recorded for Candida albicans (ATCC 10231), although it showed freedom for the test strains of Pseudomonas aeruginosa (ATCC 9027) and Staphylococcus aureus (ATCC 6638) . However, clustering with Aspergillus brasiliensis (ATCC 16404) was established. The KoKo test was rejected and there was severe clustering of yeast and mold after only one inoculation cycle.

Comparative Example 4

An aqueous polyvinylpyrrolidone (PVP) solution (Luviskol K 90L, 20% strength aqueous solution) was mixed with a preservative of phenoxyethanol (Protectol PE). The concentration of phenoxyethanol in the PVP solution is 1%.

Ph. Eur., 7th Edition did not pass the germicidal loading test. After 28 days, significant Aspergillus brasiliensis communityization was created. The more stringent KoKo test showed severe clustering after only one inoculation cycle of bacteria, fungi, and yeast.

All comparative concentrations of 0.75-1% Euxyl PE 9010 (ethylhexyl glycerol and phenoxyethanol) or 0.1-0.2% Euxyl K 220 (ethylhexyl glycerol and phenoxyethanol) were associated with turbidity, discoloration, strong odor intensity after storage Product instability and unacceptable performance of turbidity, discoloration, reduced viscosity of the formulation such as gel.

Claims (15)

An aqueous polymer solution stabilized with the following preservative mixture:
0.01 to 0.2% by weight of ethylhexyl glycerol
- 0.001 to 0.01% by weight of 2-methylisothiazolinone
- 0.05 to 0.5% by weight of phenoxyethanol. The polymeric solution of claim 1, comprising:
0.04 to 0.15% by weight of ethylhexyl glycerol
- 0.003 to 0.008% by weight of 2-methylisothiazolinone
0.1 to 0.5% by weight of phenoxyethanol. 3. The polymer solution according to claim 1 or 2, comprising:
0.04 0.004% by weight of ethylhexyl glycerol,
- 0.0038 + 0.0004% by weight of 2-methylisothiazolinone and
0.5% by weight of phenoxyethanol. 4. The composition according to any one of claims 1 to 3, wherein the polymer is selected from the group consisting of vinyl lactam polymers, polyethers, polyalkyleneimines, polyvinylamines, polyvinylformamides and partial hydrolyzates thereof, polyimides, And mixtures thereof. 5. The composition of claim 4 wherein the polymer is selected from the group consisting of N-vinylpyrrolidone, N-vinylcaprolactam, vinyl acetate, vinylformamide, polyurethane, and vinylamine or N-vinylimidazole And a polymer solution selected from quaternized vinylimidazole and styrene and styrene derivatives. A preservative mixture having the following ingredients as disinfecting active ingredients:
- 62.5% by weight of phenoxyethanol
- 25.0% by weight of ethylhexyl glycerol and
- 1.25% by weight of 2-methylisothiazolinone and
- Residual water. The preservative mixture according to claim 6, used in an amount of 0.08 to 0.8% by weight based on the aqueous polymer solution according to claim 1. A preservative mixture having the following ingredients as disinfecting active ingredients:
- 86.20% by weight of phenoxyethanol
- 6.9% by weight of ethylhexyl glycerol and
- 0.69% by weight of 2-methylisothiazolinone and
- Residual water. The preservative mixture according to claim 8, which is used in an amount of 0.4 to 0.6% by weight based on the aqueous polymer solution according to claim 3. A polymer obtained from an aqueous solution according to any one of claims 1 to 5. 11. The polymer of claim 10, which is obtained by drying. Use of an aqueous polymer solution according to any one of claims 1 to 5 or a polymer according to claims 10 or 11 in cosmetic formulations. 13. Use according to claim 12 in a skin care and hair care composition. Use of an aqueous polymer solution according to any one of claims 1 to 5 or a polymer according to claims 10 or 11 in a hair styling product. Use of the aqueous polymer solution according to any one of claims 1 to 5 or the polymer according to claims 10 or 11 in decorative cosmetics and hair and body cleansing products.