KR20150010882A - 아넥신 A2 결합단백질, p53 단백질 및 p18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물 - Google Patents

아넥신 A2 결합단백질, p53 단백질 및 p18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물 Download PDF

Info

Publication number
KR20150010882A
KR20150010882A KR20130085513A KR20130085513A KR20150010882A KR 20150010882 A KR20150010882 A KR 20150010882A KR 20130085513 A KR20130085513 A KR 20130085513A KR 20130085513 A KR20130085513 A KR 20130085513A KR 20150010882 A KR20150010882 A KR 20150010882A
Authority
KR
South Korea
Prior art keywords
protein
fusion protein
cancer
terminal
domain
Prior art date
Application number
KR20130085513A
Other languages
English (en)
Korean (ko)
Inventor
김정민
이재일
이정민
Original Assignee
삼성전자주식회사
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 삼성전자주식회사 filed Critical 삼성전자주식회사
Priority to KR20130085513A priority Critical patent/KR20150010882A/ko
Priority to PCT/KR2014/006510 priority patent/WO2015009082A1/fr
Publication of KR20150010882A publication Critical patent/KR20150010882A/ko

Links

Images

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K19/00Hybrid peptides, i.e. peptides covalently bound to nucleic acids, or non-covalently bound protein-protein complexes
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4746Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used p53
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702Regulators; Modulating activity
    • C07K14/4703Inhibitors; Suppressors
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4721Lipocortins
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62DNA sequences coding for fusion proteins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biotechnology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Peptides Or Proteins (AREA)
KR20130085513A 2013-07-19 2013-07-19 아넥신 A2 결합단백질, p53 단백질 및 p18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물 KR20150010882A (ko)

Priority Applications (2)

Application Number Priority Date Filing Date Title
KR20130085513A KR20150010882A (ko) 2013-07-19 2013-07-19 아넥신 A2 결합단백질, p53 단백질 및 p18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물
PCT/KR2014/006510 WO2015009082A1 (fr) 2013-07-19 2014-07-17 Protéine de fusion comprenant la protéine de liaison annexine a2, la protéine p53 et la protéine p18, et composition la contenant pour la prévention ou le traitement du cancer

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR20130085513A KR20150010882A (ko) 2013-07-19 2013-07-19 아넥신 A2 결합단백질, p53 단백질 및 p18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물

Publications (1)

Publication Number Publication Date
KR20150010882A true KR20150010882A (ko) 2015-01-29

Family

ID=52346455

Family Applications (1)

Application Number Title Priority Date Filing Date
KR20130085513A KR20150010882A (ko) 2013-07-19 2013-07-19 아넥신 A2 결합단백질, p53 단백질 및 p18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물

Country Status (2)

Country Link
KR (1) KR20150010882A (fr)
WO (1) WO2015009082A1 (fr)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112409447B (zh) * 2019-08-20 2023-06-20 辽宁医学诊疗科技研发中心有限公司 一种靶向识别膜联蛋白a2的亲和短肽及其制备方法与用途

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6645465B2 (en) * 1999-08-06 2003-11-11 Michigan, University Of The Regents Annexin proteins and autoantibodies as serum markers for cancer
KR20090029868A (ko) * 2007-09-19 2009-03-24 한국생명공학연구원 체액 내 간암 마커로서의 아넥신 2 및 이를 이용한 간암진단 키트
KR101643761B1 (ko) * 2009-12-04 2016-07-29 삼성전자주식회사 유비퀴틴 또는 유비퀴틴-유사 단백질, 막 투과 도메인 및 생물학적 활성분자를 포함하는 융합 단백질 및 그의 용도

Also Published As

Publication number Publication date
WO2015009082A1 (fr) 2015-01-22

Similar Documents

Publication Publication Date Title
EP1811033B1 (fr) Inhibiteurs peptidiques à perméabilité cellulaire du processus de transduction du signal de JNK
DK2661496T3 (en) FUSION PROTEIN AS ANTICANCING AGENT
CA2590512A1 (fr) Proteine de fusion comprenant un domaine bh3 de proteine bh3 seulement
US8183339B1 (en) Cell-permeable peptide inhibitors of the JNK signal transduction pathway
US20140031283A1 (en) Anticancer fusion protein
CA2255143A1 (fr) Partenaires liants pour inhibiteurs de kinases cyclino-dependantes et leur utilisation dans la recherche d'inhibiteurs et de diagnostics ou d'une therapie de maladie
KR20240124255A (ko) Vgll1 펩타이드를 포함하는 암 치료용 조성물
KR20160126340A (ko) 3중-나선 다발 단백질 및 이의 용도
WO2019196790A1 (fr) Protéine de fusion antitumorale, son procédé de préparation et son utilisation
CN105999227A (zh) FOXM1蛋白氮端(1-234 aa)的表达及其用途
KR20140138507A (ko) 아넥신 A1 결합단백질, p53 단백질, 및 p18 또는 p16 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물
MXPA01008626A (es) Inhibidor novedoso de muerte programada de celula.
KR102092345B1 (ko) 류신 지퍼 변이체 및 이의 용도
KR20150010882A (ko) 아넥신 A2 결합단백질, p53 단백질 및 p18 단백질을 포함하는 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물
AU2014247131A1 (en) Artificial transcription factors for the treatment of diseases caused by OPA1
KR20150053539A (ko) p53 단백질 및 p15 단백질이 결합된 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물
KR20150053177A (ko) p53 단백질 및 p16 단백질이 결합된 융합 단백질 및 이를 포함하는 암의 예방 또는 치료용 조성물
KR20210131909A (ko) 암의 예방 또는 치료를 위한 Runx3 변이 단백질
AU2018302855B2 (en) Peptide derivative and pharmaceutical composition containing same
EP2708241A1 (fr) Protéine de fusion Fc de recombinaison des deux domaines d'immunoglobuline de UNC5
KR20150012572A (ko) p53 단백질 및 p18 단백질이 결합된 융합 단백질을 포함하는 암의 예방 또는 치료용 약학적 조성물 및 이의 용도
US8404806B2 (en) Isolated BRCA1 peptides and method of use
US20240294587A1 (en) K-ras inhibitor
US6720158B2 (en) Splice variants of BRCA1
KR20240153448A (ko) Igfbp5 돌연변이체 또는 이를 발현하는 벡터를 유효성분으로 포함하는 암 예방 또는 치료용 약학적 조성물

Legal Events

Date Code Title Description
WITN Application deemed withdrawn, e.g. because no request for examination was filed or no examination fee was paid