KR20150004388U - Sensor strip structure - Google Patents

Abstract

The sensor strip structure includes a reaction part for reacting with a biological fluid, an upper plate disposed on the reaction part, wherein the reaction hole has first holes for supplying a biological fluid to the reaction part, and a lower plate disposed below the reaction part, A sensor strip including a lower plate on which second holes for measuring the reflectance of the reaction part are formed, and a holder having a groove for receiving and fixing the sensor strip and exposing a region where the second holes are formed in the sensor strip can do. Therefore, it is possible to prevent the light reflected from the reaction part from being blocked by the holder.

Description

Sensor strip structure [0002]

The present invention relates to a sensor strip structure, and relates to a sensor strip structure for detecting disease using blood.

Generally, sensor strip structures are used to detect disease using blood.

FIG. 1 is a plan view for explaining a sensor strip structure according to the related art, and FIG. 2 is a sectional view taken along line A-A 'of the sensor strip structure shown in FIG.

1 and 2, the sensor strip structure 1 comprises a strip 10 and a holder 20 for fixing the strip 10.

In the strip 10, the reaction part 12 containing the reaction reagent is disposed between the upper plate 14 and the lower plate 16. The upper plate 14 is formed with first holes 15 for supplying blood to the reaction unit 12 and the lower plate 16 is formed with second holes 17 for measuring the reflectance of the reaction unit 12 do.

On the lower surface of the holder 20, third holes 22 connected to the second holes 17 are provided.

3 is a cross-sectional view illustrating a disease detection method using the sensor strip structure shown in FIG.

3, the sensor strip structure 1 is inserted into a diagnostic unit, and the light source of the diagnostic unit vertically irradiates the light from the lower part of the sensor strip structure 1 to the reaction part 12, 12 to detect the disease. At this time, the light source and the detection unit form an angle of 45 degrees.

In the sensor strip structure 1, the reaction part 12 is exposed by the second holes 17 and the third holes 22. The lower plate 16 and the holder 20 in which the second holes 17 and the third holes 22 are formed can block the light reflected from the reaction part 12. As the depth to the reaction part 12 becomes deeper, the reflected light blocked by the lower plate 16 and the holder 20 increases. That is, the reflected light that can be detected by the detection unit is reduced. Therefore, the reliability of disease detection using the reflected light can be reduced.

Meanwhile, the sizes of the second holes 17 and the third holes 22 may be increased to increase the reflected light. As the size of the second holes 17 and the third holes 22 increases, the size of the reaction part 12 must also increase. When the size of the reaction part 12 increases, the amount of blood required for the disease detection increases.

The present invention provides a sensor strip structure that can minimize blocking of reflected light reflected from a reaction part.

According to an aspect of the present invention, there is provided a sensor strip structure including a reaction part for reacting with a biological fluid, an upper plate disposed above the reaction part and including first holes for supplying a biological fluid to the reaction part, A sensor strip formed of a lower plate formed with second holes for measuring reflectance of the reaction part, and a groove for receiving and fixing the sensor strip and exposing a region where the second holes are formed in the sensor strip, The holder may include a holder.

According to one embodiment of the present invention, the lower plate has a shape protruding downward, and the protruding portion is inserted into a groove formed in the bottom plate of the holder, so that the sensor strip and the holder can be combined.

According to one embodiment of the present invention, the bottom surface of the protruding portion and the bottom surface of the bottom plate may have the same height.

According to one embodiment of the present invention, the holder includes a bottom plate having a handle formed on one side thereof and having a groove for engaging with the projected portion, and a plurality of projections protruding from both side ends of the bottom plate, And the guide for guiding the sensor strip when the sensor strip is inserted into the holder.

According to one embodiment of the present invention, the holder may further include a stopper for blocking one end of the guide to define a depth of insertion of the sensor strip.

According to one embodiment of the present invention, the holder may have alignment grooves on the top surface of the stopper for aligning the position of the cuvette for supplying the biological fluid through the first holes.

The sensor strip structure according to the present invention forms a groove exposing a portion where the second holes of the strip are formed at the lower end of the holder. Therefore, it is possible to prevent the light reflected from the reaction part from being blocked by the holder. Also, the depth of the reaction part of the strip can be minimized, and the blocking of the reflected light can be reduced. Therefore, the reliability of disease detection using the reflected light can be improved.

The sensor strip structure may have a protruding portion on the lower plate of the strip, and the protruding portion may be inserted into the groove of the holder. Therefore, the space between the reaction part and the optical part for irradiating the light to the reaction part can be reduced as the lower plate protrudes. Therefore, the intensity of the light irradiated to the reaction part and the intensity of the reflected light can be increased. Therefore, the reliability of disease detection using the reflected light can be further improved.

The sensor strip structure can reduce the blocking of the reflected light and increase the intensity of the light and the intensity of the reflected light so that the disease detection using the reflected light can be sufficiently performed even if the size of the reaction part is reduced. Since the size of the reaction part can be reduced, the manufacturing cost of the sensor strip structure can be reduced, and the amount of blood required for the disease detection can be reduced.

1 is a plan view for explaining a sensor strip structure according to the prior art.
FIG. 2 is a cross-sectional view of the sensor strip structure shown in FIG. 1 taken along line AA '.
3 is a cross-sectional view illustrating a disease detection method using the sensor strip structure shown in FIG.
4 is a plan view illustrating a sensor strip structure according to an embodiment of the present invention.
FIG. 5 is a cross-sectional view of the sensor strip structure shown in FIG. 4 taken along line BB '.
6 is a cross-sectional view for explaining another example of the sensor strip structure shown in FIG.
7 is a cross-sectional view illustrating a disease detection method using the sensor strip structure of the present invention.
Figs. 8 and 9 are graphs showing the reflectance of the sensor strip structure according to the related art.
10 and 11 are graphs showing the reflectance of the sensor strip structure according to the prior art.
12 and 13 are graphs showing the reflectance of the sensor strip structure according to the present invention.

Hereinafter, a sensor strip structure according to an embodiment of the present invention will be described in detail with reference to the accompanying drawings. The present invention is capable of various modifications and various forms, and specific embodiments are illustrated in the drawings and described in detail in the text. It should be understood, however, that the appended claims are not intended to limit the invention to the particular forms disclosed, but to include all modifications, equivalents, and alternatives falling within the spirit and scope of the invention. Like reference numerals are used for like elements in describing each drawing. In the accompanying drawings, the dimensions of the structures are enlarged from the actual size in order to clarify the present invention.

The terms first, second, etc. may be used to describe various components, but the components should not be limited by the terms. The terms are used only for the purpose of distinguishing one component from another. For example, without departing from the scope of the present invention, the first component may be referred to as a second component, and similarly, the second component may also be referred to as a first component.

The terminology used herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention. The singular expressions include plural expressions unless the context clearly dictates otherwise. In this application, the terms "comprises", "having", and the like are used to specify that a feature, a number, a step, an operation, an element, a part or a combination thereof is described in the specification, But do not preclude the presence or addition of one or more other features, integers, steps, operations, components, parts, or combinations thereof.

Unless otherwise defined, all terms used herein, including technical or scientific terms, have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. Terms such as those defined in commonly used dictionaries are to be interpreted as having a meaning consistent with the contextual meaning of the related art and are to be interpreted as either ideal or overly formal in the sense of the present application Do not.

FIG. 4 is a plan view illustrating a sensor strip structure according to an embodiment of the present invention, and FIG. 5 is a cross-sectional view of the sensor strip structure shown in FIG. 4 taken along line B-B '.

Referring to FIGS. 4 and 5, the sensor strip structure 100 includes a strip 110 and a holder 120.

The strip 110 is for detecting a disease using a biological fluid, for example, blood, and includes a reaction part 111, a top plate 112, and a bottom plate 114.

The reaction part 111 is for reacting with the biological fluid, and may include a net layer, a separation layer, and a reaction layer.

The netting layer has a mesh structure, which allows the injected biological fluid to spread evenly. If the pore size of the netting layer is less than about 100 microns, the netting layer is too dense, so that some of the components of the biological fluid that are large in size are caught by the netting layer, preventing the biological fluid from being absorbed into the lower layer of the netting layer Lt; / RTI > For example, if the biological fluid is blood, blood cells in the blood component may be caught in the netting layer. Therefore, the time required for the biological fluid to be absorbed into the lower layer may be increased. If the pore size of the netting layer exceeds about 500 탆, the netting layer is brittle and can be absorbed into the bottom layer before the biological fluid spreads uniformly. Thus, the effect of uniform spreading of the biological fluid by the netting layer can be reduced.

Therefore, it is preferable that the hole size of the netting layer is about 100 to 500 mu m.

The separating layer is disposed below the netting layer and is capable of separating certain components from the biological fluid. The specific component may be a relatively large component in the biological fluid. For example, if the biological fluid is blood, the separation layer may separate blood cells from the blood. The separation layer is made of glass fiber, and the polymer is bound to the glass fiber for separation of the specific component.

If the thickness of the separating layer is less than about 300 탆, the separating layer is thin and the specific component is not properly separated. If the thickness of the separating layer exceeds about 1000 mu m, the separating layer becomes too thick, so that it takes a very long time to separate the specific components.

Therefore, the thickness of the separation layer may be about 300 to 1000 mu m.

When the strip 110 is used for liver disease measurement and cholesterol measurement, the sensor strip 110 may include the separation layer because it is necessary to separate a specific component such as blood cells from the biological fluid.

However, when the strip 110 is used for anemia measurement, the strip 110 may not include the separation layer because separation of the specific component from the biological fluid is not necessary. In addition, even when the strip 110 is used for liver disease measurement and cholesterol measurement, separation of the specific component from the biological fluid is not required when the biological fluid is supplied in a state in which the specific component is separated in advance, ) May not include the separation layer.

The reaction layer is disposed below the separation layer and contains a reaction reagent. The reaction reagent reacts with the biological fluid. For example, in the liver disease measurement and the measurement of cholesterol level, the reaction reagent can chemically react with blood plasma separated from the blood, which is the biological fluid. The type of the reaction reagent contained in the reaction layer may vary depending on the kind of the disease to be measured and the kind of the biological fluid. The separation layer is colored according to the reaction of the reaction reagent and the biological fluid.

The reaction layer has an asymmetric structure for separation of a specific component of the biological fluid. Specifically, the reaction layer has fine pores passing through the top and bottom, and the pores have a structure in which the cross-sectional area becomes narrower from the upper surface to the lower surface of the reaction layer. Therefore, when the biological fluid passes through the pores, a relatively large component of the biological fluid hits the micropores, so that the reaction layer can separate the specific component from the biological fluid. In one example, when the biological fluid is blood, the specific component may be a blood cell.

The thickness of the reaction layer is related to the absorption capacity of the reaction layer. When the thickness of the reaction layer is less than about 100 탆, the reaction reagent contained in the reaction layer is relatively small. Therefore, since the biological fluid and the reaction reagent do not react sufficiently, the degree of generation of the reaction layer is low, so that the sensitivity of the reaction layer is lowered and accurate measurement values for the biological fluid can not be derived. In addition, when the thickness of the reaction layer is about 500 탆 or more, the reagent contained in the reaction layer is more than necessary and the reaction reagent can be abused. Therefore, since the reaction reagent is excessively used, unnecessary cost loss may occur.

Meanwhile, the reaction part 111 may further include an absorption layer.

The absorbent layer is disposed below the reaction layer and is made of a hydrophilic material. Examples of the hydrophilic material include nitrocellulose, cotton, glass fiber and the like.

Since the absorption layer is made of the hydrophilic material, the reaction fluid absorbs the biological fluid and the reaction reagent from the reaction layer while the biological fluid and the reaction reagent react with each other. In addition, the absorption layer absorbs the reaction reagent with the biological fluid of the reaction layer, so that the biological fluid and the reagent of the reaction layer can be prevented from being reversely absorbed into the upper layer, i.e., the separation layer. Therefore, the absorption layer can prevent the reaction sensitivity of the reaction layer from being lowered.

In addition, since the absorption layer absorbs the reaction reagent with the biological fluid, the absorption layer can be developed in the same manner as the reaction layer.

The absorbent layer needs a proper thickness to absorb the reaction reagent of the reaction layer. If the thickness of the absorbent layer is less than about 50 탆, the thickness of the absorbent layer is relatively thin, so that the absorbent layer can not completely absorb the absorbing reagent from the reaction layer, and the reagent may overflow. If the thickness of the absorbent layer exceeds about 150 mu m, the thickness of the absorbent layer becomes relatively thick, so that the reaction reagent of the reaction layer is not sufficiently absorbed into the absorbent layer. Therefore, color development of the absorbent layer is not normally performed.

Therefore, the thickness of the absorbent layer is preferably about 50 to 150 mu m.

On the other hand, the lower surface of the absorbing layer is coated with a transparent film. The transparent film can prevent the biological fluid absorbed in the absorption layer and the reaction reagent from evaporating through the lower surface. Further, since the transparent film is transparent, the color of the absorption layer can be displayed as it is.

The upper plate 112 is disposed on the reaction part 111 and has a substantially rectangular flat plate shape. The upper plate 112 has first holes 113. The first holes 113 are arranged in a line along the longitudinal direction of the upper plate 112 and pass through the upper and lower portions of the upper plate 112. The first holes 113 expose the reaction part 111 and the biological fluid can be injected through the first holes 113.

The lower plate 114 is disposed under the reaction part 111 and has a substantially rectangular flat plate shape. The lower plate 114 has the second holes 115. The second holes 115 are arranged in a line along the longitudinal direction of the lower plate 114 and pass through the upper and lower portions of the lower plate 114. The number of the second holes 115 is equal to the number of the first holes 113 and the second holes 115 and the first holes 113 are arranged to correspond to each other. The second holes 115 expose the reaction part 111 and the color of the reaction part 111 can be measured through the second holes 115. The hue of the reaction part 111 may be measured by irradiating light to the reaction part 111 and measuring the reflectance of the light reflected from the reaction part 111.

The upper plate 112 and the lower plate 114 can be coupled to each other. For example, fastening holes (not shown) of the upper plate 112 and fastening pins 116 of the lower plate 114 can be fastened.

On the other hand, the upper plate 112 and the lower plate 114 are hinged on one side and grooves and protrusions on the other side opposite to the one side are coupled to each other.

The reaction part 111 is disposed between the upper plate 112 and the lower plate 114 by the number of the first holes 113 (or the number of the second holes 115) and is spaced apart from each other. That is, the reaction part 111 is disposed between the first hole 113 and the second hole 115 facing each other. Since the reaction parts 111 are spaced apart from each other, the biological fluid supplied to the reaction part 111 through the first holes 113 can be prevented from moving to the other reaction parts 111. Therefore, different measurements can be made in each of the reaction parts 111.

Since the coupling holes of the upper plate 112 and the coupling pins 116 of the lower plate 114 can be disposed between the reaction parts 111 arranged apart from each other, the upper plate 112 and the lower plate 114 are constant The reaction parts 111 can be fixed by pressure.

The holder 120 is for fixing the strip 110 and may include a bottom plate 121, a handle 122, a guide 123, and a stopper 124.

The bottom plate 121 has a substantially rectangular flat plate shape and supports the strips 110. The bottom plate 121 has a larger area than the strip 110.

The bottom plate 121 has a groove 121a that exposes the second holes 115 of the supported strip 110. Specifically, the groove 121a is formed to extend along the longitudinal direction at one end in the width direction of the bottom plate 121. [

Therefore, the light reflected from the reaction part 111 is blocked by the lower plate 114 having the second holes 115, but is not blocked by the bottom plate 121 of the holder 120. That is, by minimizing the depth of the strip 110 to the reaction part 111, it is possible to minimize the blocking of the reflected light. Therefore, the reliability of disease detection using the reflected light can be improved.

The handle 122 is provided at the other end opposite to one end in the width direction of the bottom plate 121. The handle 122 allows the user to easily grip the sensor strip structure 100.

The guide 123 protrudes in the direction perpendicular to the bottom plate 121 from both upper end surfaces in the longitudinal direction of the bottom plate 121, and is bent to face each other. The protruding height of the guide 123 is substantially the same as the height of the strip 110. Therefore, the guide 123 can support the side and top surface of the strip 110. [

The guide 123 can support the side surface and the upper surface of the strip 110 so that the guide 123 can guide the movement of the strip 110 when the strip 110 is fixed to the holder 120. [ In addition, the guide 123 can uniformly press the upper surface of the strip 110 using the bent portion. Therefore, a measurement error due to uneven pressure applied to the strip 110 can be prevented.

The stopper 124 protrudes in a vertical direction from any one of upper and lower opposite ends of the bottom plate 121 to block one of the open ends of the guide 123. For example, the stopper 124 may be provided at the other end in the width direction of the bottom plate 121. In this case, the strip 110 may be inserted into and fixed to the holder 120 from one end in the width direction of the bottom plate 121.

The stopper 124 contacts the longitudinal side of the strip 110 inserted into the holder 120 to define the insertion depth of the strip 110. Accordingly, the strip 110 may be inserted into the holder 120 and fixed at a predetermined position.

The stopper 124 may include alignment holes 124a. The alignment holes 124a are provided on the upper surface of the stopper 124. Specifically, the alignment holes 124a are located on the upper surface of the stopper 124 at the exposed portions without being covered by the guide 123. [

When the cuvette (not shown) for supplying the biological fluid joins the sensor strip structure 100, the protrusion of the cuvette is inserted into the alignment hole 124a so that the cuvet can accurately engage with the sensor strip structure 100 . Accordingly, the biological fluid of the cuvette can be accurately supplied to the reaction part 111 through the first holes 113 of the strip 110.

The holder 120 may further include an auxiliary guide 125.

The auxiliary guide 125 extends horizontally from the exposed portion of the stopper 124 so as to be parallel to the bottom plate 121 without being covered by the guide 123. At this time, the extending direction of the auxiliary guide 125 may be the width direction of the bottom plate 121.

The auxiliary guide 125 can support the upper surface of the strip 110 exposed by the guide 123. That is, the auxiliary guide 125 can support the upper surface portion of the strip 110, which is not supported by the bent portion of the guide 123. Accordingly, the upper surface of the strip 110 can be supported by the guide 123 as well as the auxiliary guide 125. Therefore, the upper surface of the strip 110 can be more uniformly pressed.

6 is a cross-sectional view for explaining another example of the sensor strip structure shown in FIG.

Referring to FIG. 6, the lower plate 114 of the strip 110 may protrude downward at a central portion thereof. At this time, the lower plate 114 may have a uniform thickness as a whole. That is, the lower plate 114 may have the same thickness except for the protruding portion and the protruding portion.

The width of the projecting portion in the lower plate 114 is substantially equal to the width of the groove 121a in the bottom plate 121. [ When the strip 110 and the holder 120 are engaged with each other, the projecting portion of the lower plate 114 can be inserted into the groove 121a formed in the bottom plate 121 of the holder 120. [ Therefore, the strip 110 and the holder 120 can be joined more stably.

The bottom surface of the projecting portion of the lower plate 114 is positioned at the same height as the bottom surface of the bottom plate 121 or at a height higher than the bottom surface of the bottom plate 121 in a state where the strip 110 and the holder 120 are engaged Can be located. Therefore, the protruding portion of the lower plate 114 does not protrude to the bottom surface of the holder 120, so that the sensor strip structure 100 can be easily inserted into the diagnostic device without interfering with the diagnostic device.

Since the lower plate 114 has a uniform thickness and protrudes downward, the height of the reaction part 111 is also lowered as the lower plate 114 protrudes. Also, the height of the reaction part 110 in the sensor strip structure 100 is also lowered.

Therefore, as the lower plate 114 is protruded, the distance between the reaction part 111 and the optical part for irradiating the light to the reaction part 111 can be reduced. When the light of a certain intensity is irradiated from the optical unit, the distance between the optical unit and the reaction 111 decreases, and thus the intensity of light incident on the reaction unit 111 may increase relatively. Also, the intensity of the reflected light reflected from the reaction part 111 can be relatively increased. As the intensity of the reflected light increases, the disease can be accurately identified. Therefore, the reliability of the disease detection can be further improved by using the sensor strip structure 100.

The sensor strip structure 100 may have a groove 121a formed in the bottom plate 121 to reduce the blocking of the reflected light and form a protruding portion on the lower plate 114 to measure the intensity of the light and the intensity of the reflected light Can be relatively increased. Therefore, even if the size of the reaction part 111 is reduced, the disease detection using the light can be sufficiently performed. Since the size of the reaction part 111 can be reduced, the manufacturing cost of the sensor strip structure 100 can be reduced, and the amount of the biological fluid required for the disease detection can be reduced.

4 to 6, the grooves 121a may be formed to extend along the longitudinal direction from one longitudinal center of the bottom plate 121. In addition, as shown in FIG. The guide 123 protrudes in the direction perpendicular to the bottom plate 121 from both upper end surfaces in the width direction of the bottom plate 121 and is bent to face each other. In this case, since the guide 123 can stably support both ends of the strip 110 in the width direction, the auxiliary guide 125 is unnecessary.

The stopper 124 protrudes vertically from the other end opposite to one longitudinal end of the bottom plate 121 and blocks one of the open ends of the guide 123. Accordingly, the strip 110 can be inserted into the holder 120 from one end in the longitudinal direction of the bottom plate 121 and fixed.

The alignment hole 124a may be provided on the upper surface of the stopper 124 or on the upper surface of the guide 123. [

7 is a cross-sectional view illustrating a disease detection method using the sensor strip structure of the present invention.

7, the sensor strip structure 100 is inserted into a diagnostic unit, and the light source of the diagnostic unit vertically irradiates the light from the lower part of the sensor strip structure 100 to the reaction part 111, 111 to detect the disease. At this time, the light source and the detection unit form an angle of 45 degrees.

The light reflected from the reaction part 111 is blocked by the bottom plate 114 formed with the second hole 115 but is not blocked by the bottom plate 121 of the holder 120. That is, since the reflected light of the reaction part 111 is blocked only by the lower plate 114, the blocking of the reflected light can be minimized. Therefore, the reliability of disease detection using the light can be improved.

Figs. 8 and 9 are graphs showing the reflectance of the sensor strip structure according to the related art.

8 shows the size of the reaction part of 8 mm * 7 mm, 30 쨉 l of blood was supplied to one reaction part, Fig. 9 shows the size of the reaction part of 5 mm * 7 mm, and 19 쨉 l of blood was supplied to one reaction part.

Referring to FIGS. 8 and 9, it can be seen that the reactivity decreases as the size of the reaction part decreases and the volume of the blood decreases. In particular, it can be seen that the resolution by concentration is decreased in the low concentration range of AST 34 U / L and AST 53 U / L. That is, when the volume of blood is reduced in the sensor strip structure according to the related art, the reactivity is lowered.

FIGS. 10 and 11 are graphs showing the reflectance of the sensor strip structure according to the related art, and FIGS. 12 and 13 are graphs showing the reflectance of the sensor strip structure according to the present invention.

10 and 11, the size of the reaction part was 8 mm * 7 mm, and 30 μl of blood was supplied to one reaction part. 12 and 13, the size of the reaction part was 5 mm * 5 mm, and 15 쨉 l of blood was supplied to one reaction part.

10 to 13, even when the size and blood volume of the reaction portion of the sensor strip structure of the present invention are reduced compared to the size and volume of the reaction portion of the conventional sensor strip structure, the resolution per concentration is improved without decreasing the resolution in the low concentration region . That is, it can be seen that the sensor strip structure of the present invention improves the reactivity even when the volume of blood is reduced as compared with the sensor strip structure according to the prior art.

As described above, the sensor strip structure according to the present invention can prevent the light reflected from the reaction part from being blocked by the holder. In addition, the lower plate of the strip may form a protruding portion so that the interval between the reaction portion and the optical portion for irradiating light with the reaction portion can be reduced. The intensity of the light irradiated to the reaction part and the intensity and amount of the reflected light can be increased. Therefore, the reliability of disease detection using the reflected light can be further improved.

The sensor strip structure can reduce the blocking of the reflected light and increase the intensity of the light and the intensity of the reflected light. Therefore, even if the size of the reaction part is reduced, the disease detection using the reflected light can be sufficiently performed. Since the size of the reaction part can be reduced, the manufacturing cost of the sensor strip structure can be reduced, and the amount of blood required for the disease detection can be reduced.

It will be apparent to those skilled in the art that various modifications and variations can be made in the present invention without departing from the spirit or scope of the invention as defined in the appended claims. It will be understood that the present invention can be changed.

100: sensor strip structure 110: strip
111: reaction part 112: top plate
114: lower plate 120: holder
121: bottom plate 122: handle
123: Guide 124: Stopper
125: Auxiliary guide

Claims (6)

A reaction part for reacting with the biological fluid, an upper plate disposed on the reaction part and formed with first holes for supplying the biological fluid to the reaction part, and a lower plate disposed below the reaction part and coupled with the upper plate, A sensor strip formed of a lower plate on which second holes for measuring reflectance are formed; And
And a holder having a groove for receiving and fixing the sensor strip and exposing a region where the second holes are formed in the sensor strip. The sensor strip structure according to claim 1, wherein the lower plate has a shape protruding downward, and the protruding portion is inserted into a groove formed in the bottom plate of the holder, thereby coupling the sensor strip and the holder. The sensor strip structure according to claim 2, wherein the bottom surface of the projecting portion and the bottom surface of the bottom plate have the same height. 2. The holder according to claim 1,
A bottom plate having a handle on one side and a groove for engaging with the projecting portion; And
And a guide that protrudes from both side ends of the bottom plate and is bent in directions opposite to each other and guides the sensor strip when the sensor strip is inserted into the holder. 5. The sensor strip structure of claim 4, wherein the holder further comprises a stopper for blocking one end of the guide to define a depth of insertion of the sensor strip. 6. The sensor strip structure according to claim 5, wherein the holder has alignment grooves for aligning the position of the cuvette for supplying the biological fluid through the first holes to the upper surface of the stopper.

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