KR20140141188A - External composition for skin containing green persimmon extract - Google Patents
External composition for skin containing green persimmon extract Download PDFInfo
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- KR20140141188A KR20140141188A KR1020130062653A KR20130062653A KR20140141188A KR 20140141188 A KR20140141188 A KR 20140141188A KR 1020130062653 A KR1020130062653 A KR 1020130062653A KR 20130062653 A KR20130062653 A KR 20130062653A KR 20140141188 A KR20140141188 A KR 20140141188A
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- skin
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- persimmon extract
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
Abstract
Description
More particularly, the present invention relates to a composition for external application for skin, which comprises a foot skin extract as an active ingredient to provide skin pore reduction and sebum secretion reduction effect.
The pores are follicles in which the epidermis of the skin grows into the dermis and the sebaceous follicles come out of the skin surface through the pores. Collagen and elastin supporting the pore wall due to aging of the skin are decomposed or altered, and when the skin elasticity is reduced, the pores are stained or stretched, and the pores are enlarged due to excessive sebum secretion.
In general, sebaceous glands in the skin, including the scalp and face, play a role in preventing moisturization and microbial invasion of the skin. However, excessive secretion of sebum promotes hair loss, worsens acne, promotes enlargement of pores caused by acne, And many other diseases are caused.
The hypersecretion of sebaceous glands is caused by various causes, and the most important one is the activation of sebaceous glands by the amount of dihydrotestosterone (DHT), which is one of the hormones involved in promoting sebaceous secretion in the activity of sebaceous glands, Is overdone. In the skin and sebaceous glands, testosterone is converted to dihydrotestosterone by 5-alpha-
Recently, plant extracts have been developed as raw materials for cosmetic products for shrinking pores and skin cosmetics, but there has been no report on the effect of convergence of pores on the extracts of footprints.
Accordingly, the present inventors have found that the extract of footprints exhibits an immediate physical convergence effect through crosslinking with the epidermal protein, and exhibits indirect pore tightening effect by preventing collagen degradation, as well as suppressing sebum hypersecretion, And thus the present invention has been completed.
Accordingly, an object of the present invention is to provide a composition for external application for skin, which contains a footwear extract as an active ingredient, and exhibits an effect of reducing pores and reducing sebum.
In order to accomplish the above object, the present invention provides a composition for external application for skin comprising a foot-fall extract as an active ingredient.
In one embodiment of the present invention, the composition for external application for skin is characterized by being a composition for external application for skin reduction.
In an embodiment of the present invention, the composition for external application for skin is a composition for external application for skin to reduce sebum secretion.
Hereinafter, the present invention will be described more specifically.
The present invention relates to a composition for external application for skin containing a foot-fall extract as an active ingredient.
The sense used in one embodiment of the present invention uses an unmatured green state footprint. The footwear refers to a mature feeling and is conventionally used for dyeing clothes of clothes. It is said that when dyeing clothes with Jeju footwear, the tissue is strong and is not easily separated, and components such as catechin, quercetin, kaempferol And the like), and it is also said to be used for hardening leather. In the present invention, it is preferable that the freshness is harvested from July to September with a lot of tannin components, and generally, an immature fruit having a diameter of about 2 to 6 cm is used. Tannin content is decreased when mature sense is used and excessively immature fruit is insufficient in the amount of extract to be taken. In case of fall fruit, the amount of tannin is decreased due to the decay of wound area and oxidizing enzyme action. Therefore, It is desirable not to use perspiration or decay.
In one embodiment of the present invention, the ginseng persimmon ( Diospyros kaki ), Goomae ( Diospyros lotus , Diospyros oleifera cheng ), American persimmon ( Diospyros virginiana ) can be used. Preferably, Jeju Island persimmon ( Diospyros kaki ) can be used. Jeju Island, which is native to Jeju Island, has been used for dyeing Jeju traditional clothes. Its scientific name is Diospyros Although the same name is used for kaki , the content of tannin is much higher than that of general taste, and the size of fruit when mature is smaller than the general sense. The leaf extract of the present invention is hereinafter referred to as the Jeju leaf extract.
The footpath extract used in one embodiment of the present invention can be obtained according to methods known in the art, for example, by grinding the juice of a Jeju footpath and grinding it using a cloth. The juice was lyophilized and placed in a mixture of propanediol and water in a volume ratio of juice: propanediol: water = 1: 4: 5, followed by successive addition of diatomaceous earth to 3, 1, Filtration is carried out to obtain a filtrate. Activated carbon was added to the filtrate, stirred at 70 ° C for 12 hours for decolorization and deodorization, and then 40% propanediol solution was added thereto at a volume ratio of the filtrate: propanediol = 5: 95 through the decolorization and deodorization process . It is sterilized at 70 ° C for 24 hours, precipitated at 4 ° C for 24 hours, and then filtered sequentially at 1 μm and 0.3 μm.
In one embodiment of the present invention, the footpad extract exhibits an inhibitory effect on sebum secretion and can be used as a composition for external skin application for reducing sebum secretion. The tannin component of the footpad extract forms a cross-link with skin epidermal protein, And inhibits collagen degradation by inhibiting MMP-1 expression. Thus, it exhibits indirect pore tightening effect by increasing skin elasticity and reduces sebaceous secretion through inhibition of 5α-reductase activity, And as a result, it has a very effective effect of reducing pores. Therefore, it can be used as a skin external composition for pore reduction.
In one embodiment of the present invention, the footbath extract may be contained in an amount of 0.001 to 99.9% by weight, preferably 0.001 to 50% by weight, based on the total weight of the composition. If the content is less than 0.001% by weight, the efficacy is insufficient. When the content is more than 50% by weight, it is not economical because no marked increase in the efficacy is observed due to an increase in the content.
The present invention relates to a skin external preparation containing an extract of footprints as an active ingredient according to an embodiment of the present invention. The external preparation for skin is a generic term that may include any substance applied outside the skin, and various cosmetic formulations or medicaments . The external preparation for skin may be a skin external preparation for reducing sebum secretion, for converging skin or for reducing pores.
The pharmaceutical composition may further contain a preservative, a stabilizer, a wetting agent or an emulsifying accelerator, a pharmaceutical adjuvant such as a salt and / or a buffer for controlling osmotic pressure, and other therapeutically useful substances, May be formulated into oral administration forms. Parenteral dosage forms, and may be, for example, but not limited to lotions, ointments, gels, creams, patches or spray formulations.
The dosage of the active ingredient is within the level of those skilled in the art, and the daily dose of the drug depends on various factors such as the degree of progress of the subject to be administered, the age of onset, age, health condition, As a standard, it is generally possible to administer the composition at a dose of 1 / / kg to 200 mg / kg, preferably 50 / / kg to 50 mg / kg, once or twice a day, Are not intended to limit the scope of the present invention.
The formulation of the cosmetic composition is not particularly limited and may be appropriately selected according to the purpose. For example, skin lotion, skin softener, skin toner, astringent, lotion, milky lotion, moisturizing lotion, nutrition lotion, massage cream, nutritional cream, moisturizing cream, hand cream, foundation, essence, nutrition essence, pack, soap, cleansing But the present invention is not limited thereto, and may be manufactured by any one or more formulations selected from the group consisting of a foam, a cleansing lotion, a cleansing cream, a body lotion and a body cleanser.
When the formulation of the present invention is a paste, cream or gel, animal fiber, plant fiber, wax, paraffin, starch, tracant, cellulose derivative, polyethylene glycol, silicone, bentonite, silica, talc or zinc oxide may be used as the carrier component .
When the formulation of the present invention is a powder or a spray, lactose, talc, silica, aluminum hydroxide, calcium silicate or polyamide powder may be used as a carrier component. In the case of a spray, in particular, / Propane or dimethyl ether.
In the case of the solution or emulsion of the present invention, a solvent, a solvent or an emulsifier is used as a carrier component, and examples thereof include water, ethanol, isopropanol, ethyl carbonate, ethyl acetate, benzyl alcohol, benzyl benzoate, propylene glycol, , 3-butyl glycol oil, glycerol aliphatic ester, polyethylene glycol or sorbitan fatty acid esters.
When the formulation of the present invention is a suspension, a carrier such as water, a liquid diluent such as ethanol or propylene glycol, a suspending agent such as ethoxylated isostearyl alcohol, polyoxyethylene sorbitol ester and polyoxyethylene sorbitan ester, Cellulose, aluminum metahydroxide, bentonite, agar or tracant, etc. may be used.
When the formulation of the present invention is an interfacial active agent-containing cleansing, the carrier component may include aliphatic alcohol sulfate, aliphatic alcohol ether sulfate, sulfosuccinic acid monoester, isethionate, imidazolinium derivative, methyltaurate, sarcosinate, fatty acid amide Ether sulfates, alkylamidobetaines, aliphatic alcohols, fatty acid glycerides, fatty acid diethanolamides, vegetable oils, linolenic derivatives or ethoxylated glycerol fatty acid esters.
The cosmetic composition may further contain a functional additive and a component included in a general cosmetic composition in the added footwear extract. The functional additives may include water-soluble vitamins, oil-soluble vitamins, polymer peptides, polymeric polysaccharides, sphingolipids and seaweed extracts.
The cosmetic composition of the present invention may further contain, in addition to the above-described functional additive, components contained in a general cosmetic composition as required. Examples of the other ingredients that can be included in the composition include humectants, emollients, surfactants, organic and inorganic pigments, organic powders, ultraviolet absorbents, preservatives, bactericides, antioxidants, plant extracts, pH adjusters, alcohols, Accelerators, coolants, antiperspirants, purified water, and the like.
The present invention aims at achieving immediate physical convergence through crosslinking with epidermal protein, inhibiting the increase of MMP-1 expression by ultraviolet irradiation, inhibiting collagen degradation, increasing skin elasticity, indicating indirect pore tightening, and 5α-reductase It is possible to provide a composition for external application for skin which can reduce the secretion of sebum through the inhibition of activity and prevent the expansion of pores to thereby directly or indirectly reduce pores.
FIG. 1 is a graph showing the results of MMP-1 production test results of a foot-mouthwash extract according to Test Example 2. FIG.
The present invention will be described in more detail through the following Test Examples and Examples. However, the examples are for illustrating the present invention, and the scope of the present invention is not limited thereto.
[Referential Example 1] Preparation of Jeju Footprint Extract
After grinding the nectar of the Jeju footpath, the juice is crushed using a cloth. The juice was lyophilized and placed in a mixture of propanediol and water in a volume ratio of juice: propanediol: water = 1: 4: 5, followed by successive addition of diatomaceous earth to 3, 1, Filtration is carried out to obtain a filtrate. Activated carbon was added to the filtrate, stirred at 70 ° C for 12 hours for decolorization and deodorization, and then 40% propanediol solution was added thereto at a volume ratio of the filtrate: propanediol = 5: 95 through the decolorization and deodorization process . It is sterilized at 70 ° C for 24 hours, precipitated at 4 ° C for 24 hours, and filtered sequentially to 1 ㎛ and 0.3 ㎛.
[Test Example 1] Inhibitory effect of sebaceous hyperplasia by inhibiting 5α-reductase activity
A system was used to measure the production of 5α-dihydrotestosterone from testosterone in cells to see inhibition of 5α-reductase activity in Jeju plum extract. Human fibroblast HS68 (Cascade Biologics (Invitrogen, USA)) was added to a 24-well plate in 50,000 wells and 1 ml of DMEM medium (Dulbecco's modified Eagle's medium) containing 10% fetal bovine serum For 18 hours at < RTI ID = 0.0 > 37 C. < / RTI > Thereafter, 0.5 ml DMEM medium without FBS and the Jeju foot soup extract prepared in Reference Example 1 were prepared at the concentration (0, 3, 6, 9, 12 ppm), and the cultured cells were treated at 37 캜 for 1 hour in an incubator Lt; / RTI > Control groups were those treated with DMEM medium (0 ppm) that did not contain the plant extracts. Then, [4-14C] testosterone (3 μM) (Perkin-Elmer Life Science, NEC101010UC) labeled with isotope was added to the medium and incubated at 37 ° C. for 3 hours. The medium was then removed and the resulting isotope product Ethyl acetate (Sigma Aldrich) is removed and separated. Separate the organic layer by centrifugation at 10,000 g for 5 minutes, then treat the silica gel 60 TLC plate (Merck Millipore) to separate the product. At this time, methyl chloride, ethyl acetate, and methanol (sigma aldrich) were mixed at a ratio of 85: 15: 3. Table 1 shows the sample concentrations (IC 50 ) of 50% inhibition of 5α-reductase activity by measuring the radioactive isotope concentrations of the extracts with an AMBIS radioanalytical scanner (Ambis Inc., San Diego, Calif.) .
From the results shown in the above Table 1, it can be confirmed that the Feather extract according to the present invention has 5α-reductase activity inhibitory effect and the concentration of the Jeju Feather extract which inhibits 5α-reductase activity by 50% is determined to be 6.25 ppm I could.
[Test Example 2] Effect of collagen biosynthesis promotion to reduce pores
The following experiment was carried out to evaluate the inhibitory effect of MMP-1 on the expression of the plant extract. Human neonatal fibroblast HS68 was purchased from Cascade Biologics (Invitrogen, USA). Hs68 was cultured in DMEM medium supplemented with 10% FBS (fetal bovine serum) and 50 U / ml penicillin and 50 μg / ml streptomycin. The cells were cultured at 37 ° C and 5% CO 2 . The Hs68 was added to a 12-well plate at a concentration of 7.5 x 10 4 cells / well and incubated overnight. The next day, the medium is replaced with FBS-free medium and cultured for 24 hours. After irradiation with UVB 30 mJ / cm 2, the extract of the Jeju ground beverage prepared in Reference Example 1 was treated at a concentration of 6.25 ppm and 12.5 ppm for 48 hours. After culturing, the medium was collected and the amount of MMP-1 produced was measured using the MMP-1 assay kit (GE healthcare). The results are shown in FIG. As a control group, the non - treated group without UVB treatment, the UVB treated group and the untreated UV irradiated group were used.
1, in the human normal fibroblast monolayer culture system, the extract of Jeju plum extract according to the present invention significantly inhibited the expression of MMP-1 induced by UVB 30 mJ / cm 2, -1, thereby promoting the collagen biosynthesis and exhibiting a pore-tightening effect.
Claims (8)
Wherein said persimmon is an immature fruit of Diospyros kaki and said persimmon is a persimmon native to Jeju Island.
Wherein said Foot Shower Extract is contained in an amount of 0.001 to 99.9% by weight based on the total weight of the composition.
Wherein the composition is for reducing sebum secretion.
Wherein the composition is for shrinking pores.
Wherein said composition promotes physical pore convergence through crosslinking with epidermal protein.
Wherein said composition inhibits MMP-1 expression.
Wherein said composition inhibits 5? -Reductase activity.
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| Application Number | Priority Date | Filing Date | Title |
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| KR1020130062653A KR102039547B1 (en) | 2013-05-31 | 2013-05-31 | External composition for skin containing green persimmon extract |
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| KR1020130062653A KR102039547B1 (en) | 2013-05-31 | 2013-05-31 | External composition for skin containing green persimmon extract |
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Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090085491A (en) | 2008-02-04 | 2009-08-07 | 김두경 | A manufacturing process of gamtae dyes to improve jeju galcheon's color fastness |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20090085491A (en) | 2008-02-04 | 2009-08-07 | 김두경 | A manufacturing process of gamtae dyes to improve jeju galcheon's color fastness |
Non-Patent Citations (2)
| Title |
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| Agric. Biol. Chem., 42 (9), 1637~1643, (1978)* * |
| Critical Reviews in Food Science and Nutrition, 48:858-875, (2008)* * |
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